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1. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Vitamins

Author

Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Decsi, Tamás, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Nataša, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolaček, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesotten, Dieter, Mihályi, Krisztina, Mihatsch, Walter A., Mimouni, Francis, Mølgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, Puntis, John, Riskin, Arieh, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H.B., Van Goudoever, Johannes B., Van Kempen, Anne, Verbruggen, Sascha, Wu, Jiang, Yan, Weihui, Bronsky, J., Campoy, C., and Braegger, C.

Published
2018
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5. Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease (Nature Communications, (2020), 11, 1, (995), 10.1038/s41467-019-14275-y)

Author

Serra E. G., Schwerd T., Moutsianas L., Cavounidis A., Fachal L., Pandey S., Kammermeier J., Croft N. M., Posovszky C., Rodrigues A., Russell R. K., Barakat F., Auth M. K. H., Heuschkel R., Zilbauer M., Fyderek K., Braegger C., Travis S. P., Satsangi J., Parkes M., Thapar N., Ferry H., Matte J. C., Gilmour K. C., Wedrychowicz A., Sullivan P., Moore C., Sambrook J., Ouwehand W., Roberts D., Danesh J., Baeumler T. A., Fulga T. A., Carrami E. M., Ahmed A., Wilson R., Barrett J. C., Elkadri A., Griffiths A. M., Zurek M., Strisciuglio C., Elawad M., Lo B., Arancibia-Carcamo C., Bailey A., Barnes E., Bird-Lieberman E. L., Brain O., Braden B., Collier J., East J., Howarth L., Keshav S., Klenerman P., Leedham S., Palmer R., Powrie F., Simmons A., Walker M., Tolkien Z., Kaptoge S., Allen D., Mehenny S., Mant J., Di Angelantonio E., Thompson S. G., Yilmaz B., Juillerat P., Geuking M., Wiest R., Macpherson A. J., Bravo F. D., Brugger L., Carstens O., Bigler U. G., Heimgartner B., Rusticeanu M., Schmid-Uebelhart S., Strebel B., Tatu A., Tutuian R., Oyas O., Ramon C., Stelling J., Franc Y., Fournier N., Pittet V. E. H., Burnand B., Egger M., Golay D., Marot A., Musso L., Rossel J. -B., Seematter V., Sommer J., Vulliamy R., Michetti P., Maillard M. H., Keller C., Nydegger A., Schoepfe A., Archanioti E., Ezri J., Fraga M., Schoepfer A., Muller C., Rogler G., Biedermann L., Blattmann M., Burk S., Dora B., Fried M., Misselwitz B., Mullhaupt B., Obialo N., Pohl D., Raschle N., Scharl M., Vavricka S., Von Kanel R., Zeitz J., Abdelrahman K., Ademi G., Borovicka J., Brand S., Frei R., Haarer J., Knellwolf-Grieger C., Krieger-Grubel C., Kunzler P., Meyenberger C., Meyer P., Rohrich N., Sawatzki M., Schelling M., Semadeni G. -M., Sulz M., Zimmermann D., Aepli P., Criblez D. H., Hess C., Richterich J. -P., Spalinger J., Staudenmann D., Stulz A., Wohrle S., Thomas A., Anderegg C., Kohler H., Kusche R., Antonino A. -T., Arrigoni E., Bengoa J. M., Cunningham S., de Saussure P., Girard L., de Jong D. B., Basturk P., Brunner S., Degen L., Hruz P., Bakker C. K. -D., Niess J., Balsiger B., Haldemann J., Saner G., Seibold F., Bauerfeind P., Becocci A., Belli D., Binek J., Hengstler P., Boehm S., Boldanov T., Buhr P., Koller R., Rueger V., Senning A., Burri E., Buyse S., Cao D. -T., D'Angelo F., Delarive J., Doerig C., Hessler R., Preissler C., Rentsch R., Risti B., Ritz M. A., Steuerwald M., Vogtlin J., Sagmeister M., Sauter B., Schibli S., Sokollik C., Schlauri H., Schnegg J. -F., Seirafi M., Spangenberger H., Stadler P., Staub P., Stenz V., Tempia-Caliera M., Thorens J., Truninger K., Urfer P., Viani F., Vouillamoz D., Zander S., Wyli T., Jostins L., Kennedy N. A., Ahmad T., Lamb C. A., Edwards C., Hart A., Hawkey C., Mansfield J. C., Mowat C., Newman W. G., Tremelling M., Lee J. C., Prescott N. J., Mathew C. G., Lees C. W., McGovern D. P. B., Targan S. R., Botwin G., Mengesha E., Fleshner P., Landers C., Li D., Rioux J. D., Bitton A., Cote-Daigneault J., Daly M. J., Xavier R., Morris K., Boucher G., Cho J. H., Abraham C., Merad M., Sands B., Peter I., Hao K., Itan Y., Duerr R. H., Konnikova L., Schwartz M. B., Proksell S., Johnston E., Miladinova V., Chen W., Brant S. R., Datta L., Silverberg M. S., Schumm L. P., Birch S., Giri M., Gettler K., Sharma Y., Stevens C., Lazarev M., Haritunians T., Snapper S. B., Shah N., Muise A. M., Wilson D. C., Uhlig H. H., Anderson C. A., Serra, E. G., Schwerd, T., Moutsianas, L., Cavounidis, A., Fachal, L., Pandey, S., Kammermeier, J., Croft, N. M., Posovszky, C., Rodrigues, A., Russell, R. K., Barakat, F., Auth, M. K. H., Heuschkel, R., Zilbauer, M., Fyderek, K., Braegger, C., Travis, S. P., Satsangi, J., Parkes, M., Thapar, N., Ferry, H., Matte, J. C., Gilmour, K. C., Wedrychowicz, A., Sullivan, P., Moore, C., Sambrook, J., Ouwehand, W., Roberts, D., Danesh, J., Baeumler, T. A., Fulga, T. A., Carrami, E. M., Ahmed, A., Wilson, R., Barrett, J. C., Elkadri, A., Griffiths, A. M., Zurek, M., Strisciuglio, C., Elawad, M., Lo, B., Arancibia-Carcamo, C., Bailey, A., Barnes, E., Bird-Lieberman, E. L., Brain, O., Braden, B., Collier, J., East, J., Howarth, L., Keshav, S., Klenerman, P., Leedham, S., Palmer, R., Powrie, F., Simmons, A., Walker, M., Tolkien, Z., Kaptoge, S., Allen, D., Mehenny, S., Mant, J., Di Angelantonio, E., Thompson, S. G., Yilmaz, B., Juillerat, P., Geuking, M., Wiest, R., Macpherson, A. J., Bravo, F. D., Brugger, L., Carstens, O., Bigler, U. G., Heimgartner, B., Rusticeanu, M., Schmid-Uebelhart, S., Strebel, B., Tatu, A., Tutuian, R., Oyas, O., Ramon, C., Stelling, J., Franc, Y., Fournier, N., Pittet, V. E. H., Burnand, B., Egger, M., Golay, D., Marot, A., Musso, L., Rossel, J. -B., Seematter, V., Sommer, J., Vulliamy, R., Michetti, P., Maillard, M. H., Keller, C., Nydegger, A., Schoepfe, A., Archanioti, E., Ezri, J., Fraga, M., Schoepfer, A., Muller, C., Rogler, G., Biedermann, L., Blattmann, M., Burk, S., Dora, B., Fried, M., Misselwitz, B., Mullhaupt, B., Obialo, N., Pohl, D., Raschle, N., Scharl, M., Vavricka, S., Von Kanel, R., Zeitz, J., Abdelrahman, K., Ademi, G., Borovicka, J., Brand, S., Frei, R., Haarer, J., Knellwolf-Grieger, C., Krieger-Grubel, C., Kunzler, P., Meyenberger, C., Meyer, P., Rohrich, N., Sawatzki, M., Schelling, M., Semadeni, G. -M., Sulz, M., Zimmermann, D., Aepli, P., Criblez, D. H., Hess, C., Richterich, J. -P., Spalinger, J., Staudenmann, D., Stulz, A., Wohrle, S., Thomas, A., Anderegg, C., Kohler, H., Kusche, R., Antonino, A. -T., Arrigoni, E., Bengoa, J. M., Cunningham, S., de Saussure, P., Girard, L., de Jong, D. B., Basturk, P., Brunner, S., Degen, L., Hruz, P., Bakker, C. K. -D., Niess, J., Balsiger, B., Haldemann, J., Saner, G., Seibold, F., Bauerfeind, P., Becocci, A., Belli, D., Binek, J., Hengstler, P., Boehm, S., Boldanov, T., Buhr, P., Koller, R., Rueger, V., Senning, A., Burri, E., Buyse, S., Cao, D. -T., D'Angelo, F., Delarive, J., Doerig, C., Hessler, R., Preissler, C., Rentsch, R., Risti, B., Ritz, M. A., Steuerwald, M., Vogtlin, J., Sagmeister, M., Sauter, B., Schibli, S., Sokollik, C., Schlauri, H., Schnegg, J. -F., Seirafi, M., Spangenberger, H., Stadler, P., Staub, P., Stenz, V., Tempia-Caliera, M., Thorens, J., Truninger, K., Urfer, P., Viani, F., Vouillamoz, D., Zander, S., Wyli, T., Jostins, L., Kennedy, N. A., Ahmad, T., Lamb, C. A., Edwards, C., Hart, A., Hawkey, C., Mansfield, J. C., Mowat, C., Newman, W. G., Tremelling, M., Lee, J. C., Prescott, N. J., Mathew, C. G., Lees, C. W., Mcgovern, D. P. B., Targan, S. R., Botwin, G., Mengesha, E., Fleshner, P., Landers, C., Li, D., Rioux, J. D., Bitton, A., Cote-Daigneault, J., Daly, M. J., Xavier, R., Morris, K., Boucher, G., Cho, J. H., Abraham, C., Merad, M., Sands, B., Peter, I., Hao, K., Itan, Y., Duerr, R. H., Konnikova, L., Schwartz, M. B., Proksell, S., Johnston, E., Miladinova, V., Chen, W., Brant, S. R., Datta, L., Silverberg, M. S., Schumm, L. P., Birch, S., Giri, M., Gettler, K., Sharma, Y., Stevens, C., Lazarev, M., Haritunians, T., Snapper, S. B., Shah, N., Muise, A. M., Wilson, D. C., Uhlig, H. H., and Anderson, C. A.

Published
2022

9. Malignancy and mortality in paediatric-onset inflammatory bowel disease: a 3-year prospective, multinational study from the paediatric IBD Porto group of ESPGHAN

Author

Paediatric IBD Porto Group of ESPGHAN, Joosse, M E, Aardoom, M A, Kemos, P, Turner, D, Wilson, D C, Koletzko, S, Martin-de-Carpi, J, Fagerberg, U L, Spray, C, Tzivinikos, C, Sladek, M, Shaoul, R, Roma-Giannikou, E, Bronsky, J, Serban, D E, Ruemmele, F M, Garnier-Lengline, H, Veres, G, Hojsak, I, Kolho, K L, Davies, I H, Aloi, M, Lionetti, P, Hussey, S, Veereman, G, Braegger, C P, Trindade, E, Wewer, A V, Hauer, A C, de Vries, A C H, Sigall Boneh, R, Sarbagili Shabat, C, Levine, A, de Ridder, L, Faculty of Sciences and Bioengineering Sciences, Clinical sciences, Growth and Development, Art Sciences and Archaeology, Faculty of Psychology and Educational Sciences, Clinicum, Children's Hospital, Lastentautien yksikkö, University of Helsinki, HUS Children and Adolescents, Gastroenterology & Hepatology, and Pediatrics

Subjects
Male, Colorectal cancer, CHILDREN, T-CELL LYMPHOMA, THERAPY, Inflammatory bowel disease, COLORECTAL-CANCER, 0302 clinical medicine, Risk Factors, Neoplasms, SWEDEN, T-cell lymphoma, Pharmacology (medical), Prospective Studies, Age of Onset, Young adult, Child, Cause of death, RISK, Gastroenterology, CROHNS-DISEASE, PREVALENCE, 3. Good health, THIOPURINES, Europe, 317 Pharmacy, Child, Preschool, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Adult, medicine.medical_specialty, Adolescent, Malignancy, Risk Assessment, Primary sclerosing cholangitis, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, METAANALYSIS, Hepatology, business.industry, ibd, Infant, Newborn, Infant, Cancer, Inflammatory Bowel Diseases, medicine.disease, digestive system diseases, 3121 General medicine, internal medicine and other clinical medicine, business
Abstract

Background: Risk benefit strategies in managing inflammatory bowel diseases (IBD) are dependent upon understanding the risks of uncontrolled inflammation vs those of treatments. Malignancy and mortality in IBD have been associated with disease-related inflammation and immune suppression, but data are limited due to their rare occurrence. Aim: To identify and describe the most common causes of mortality, types of cancer and previous or current therapy among children and young adults with paediatric-onset IBD. Methods: Information on paediatric-onset IBD patients diagnosed with malignancy or mortality was prospectively collected via a survey in 25 countries over a 42-month period. Patients were included if death or malignancy occurred after IBD diagnosis but before the age of 26years. Results: In total, 60 patients were identified including 43 malignancies and 26 fatal cases (9 due to cancer). Main causes of fatality were malignancies (n=9), IBD or IBD-therapy related nonmalignant causes (n=10; including 5 infections), and suicides (n=3). Three cases, all fatal, of hepatosplenic T-cell lymphoma were identified, all were biologic-naive but thiopurine-exposed. No other haematological malignancies were fatal. The 6 other fatal cancer cases included 3 colorectal adenocarcinomas and 3 cholangiocarcinomas (CCAs). Primary sclerosing cholangitis (PSC) was present in 5 (56%) fatal cancers (1 colorectal carcinoma, 3 CCAs and 1 hepatosplenic T-cell lymphoma). Conclusions: We report the largest number of paediatric-onset IBD patients with cancer and/or fatal outcomes to date. Malignancies followed by infections were the major causes of mortality. We identified PSC as a significant risk factor for cancer-associated mortality. Disease-related adenocarcinomas were a commoner cause of death than lymphomas.

Published
2018
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14. Genome screening of coeliac disease

Author

Popat, S, Bevan, S, Braegger, C P, Busch, A, O'Donoghue, D, Falth-Magnusson, K, Godkin, A, Hogberg, L, Holmes, G, Hosie, K B, Howdle, P D, Jenkins, H, Jewell, D, Johnston, S, Kennedy, N P, Kumar, P, Logan, R F A, Love, A H G, Marsh, M N, Mulder, C J, Sjoberg, K, Stenhammar, L, Walker-Smith, J, and Houlston, R S

Published
2002

17. The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation

Author

Tcymbarevich I, Eloranta J, Spalinger M, Cosin-Roger J, Lang S, Kullak-Ublick G, Wagner C, Seuwen K, Ruiz P, de Valliere C, Abdelrahman K, Ademi G, Aepli P, Thomas A, Anderegg C, Antonino A, Archanioti E, Arrigoni E, de Jong D, Balsiger B, Basturk P, Bauerfeind P, Becocci A, Belli D, Bengoa J, Biedermann L, Binek J, Blattmann M, Boehm S, Boldanova T, Borovicka J, Braegger C, Brand S, Brugger L, Brunner S, Buhr P, Burnand B, Burk S, Burri E, Buyse S, Cao D, Carstens O, Criblez D, Cunningham S, D'Angelo F, de Saussure P, Degen L, Delarive J, Doerig C, Dora B, Drerup S, Egger M, El-Wafa A, Engelmann M, Ezri J, Felley C, Fliegner M, Fournier N, Fraga M, Franc Y, Frei P, Frei R, Fried M, Froehlich F, Furlano R, Garzoni L, Geyer M, Girard L, Girardin M, Golay D, Good I, Bigler U, Gysi B, Haarer J, Halama M, Haldemann J, Heer P, Heimgartner B, Helbling B, Hengstler P, Herzog D, Hess C, Hessler R, Heyland K, Hinterleitner T, Hirschi C, Hruz P, Juillerat P, Khalid-de Bakker C, Kayser S, Keller C, Knellwolf-Grieger C, Knoblauch C, Kohler H, Koller R, Krieger-Grubel C, Kunzler P, Kusche R, Lehmann F, Macpherson A, Maillard M, Manz M, Marot A, Meier R, Meyenberger C, Meyer P, Michetti P, Misselwitz B, Mosler P, Mottet C, Muller C, Mullhaupt B, Musso L, Neagu M, Nichita C, Niess J, Nydegger A, Obialo N, Ollo D, Oropesa C, Peter U, Peternac D, Petit L, Pittet V, Pohl D, Porzner M, Preissler C, Raschle N, Rentsch R, Restellini A, Restellini S, Richterich J, Ris F, Risti B, Ritz M, Rogler G, Rohrich N, Rossel J, Rueger V, Rusticeanu M, Sagmeister M, Saner G, Sauter B, Sawatzki M, Scharl M, Schelling M, Schibli S, Schlauri H, Schluckebier D, Schmid D, Schmid-Uebelhart S, Schnegg J, Schoepfer A, Seematter V, Seibold F, Seirafi M, Semadeni G, Senning A, Sokollik C, Sommer J, Spalinger J, Spangenberger H, Stadler P, Staub P, Staudenmann D, Stenz V, Steuerwald M, Straumann A, Strebel B, Stulz A, Sulz M, Tatu A, Tempia-Caliera M, Thorens J, Truninger K, Tutuian R, Urfer P, Vavricka S, Viani F, Vogtlin J, Von Kanel R, Vouillamoz D, Vulliamy R, Wiesel P, Wiest R, Wohrle S, Zamora S, Zander S, Wylie T, Zeitz J, Zimmermann D, and Swiss IBD Cohort Study Grp

Subjects
UC, pH-sensing, cAMP, IBD, Acidic pH, RhoA, Inflammatory bowel diseases, CD
Abstract

BackgroundTissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk factor for IBD. In response to extracellular acidification, proton activation of GPR65 stimulates cAMP and Rho signalling pathways. We aimed to analyse the clinical and functional relevance of the GPR65 associated single nucleotide polymorphism (SNP) rs8005161.Methods1138 individuals from a mixed cohort of IBD patients and healthy volunteers were genotyped for SNPs associated with GPR65 (rs8005161, rs3742704) and galactosylceramidase (rs1805078) by Taqman SNP assays. 2300 patients from the Swiss IBD Cohort Study (SIBDC) were genotyped for rs8005161 by mass spectrometry based SNP genotyping. IBD patients from the SIBDC carrying rs8005161 TT, CT, CC and non-IBD controls (CC) were recruited for functional studies. Human CD14+ cells were isolated from blood samples and subjected to an extracellular acidic pH shift, cAMP accumulation and RhoA activation were measured.ResultsIn our mixed cohort, but not in SIBDC patients, the minor variant rs8005161 was significantly associated with UC. In SIBDC patients, we observed a consistent trend in increased disease severity in patients carrying the rs8005161-TT and rs8005161-CT alleles. No significant differences were observed in the pH associated activation of cAMP production between IBD (TT, CT, WT/CC) and non-IBD (WT/CC) genotype carriers upon an acidic extracellular pH shift. However, we observed significantly impaired RhoA activation after an extracellular acidic pH shift in IBD patients, irrespective of the rs8005161 allele.ConclusionsThe T allele of rs8005161 might confer a more severe disease course in IBD patients. Human monocytes from IBD patients showed impaired pH associated RhoA activation upon an acidic pH shift.

Published
2019

18. Contribution of the MHC region to the familial risk of coeliac disease

Author

Bevan, S, Popat, S, Braegger, C P, Busch, A, O'Donoghue, D, Falth-Magnusson, K, Ferguson, A, Godkin, A, Hogberg, L, Holmes, G, Hosie, K B, Howdle, P D, Jenkins, H, Jewell, D, Johnston, S, Kennedy, N P, Kerr, G, Kumar, P, Logan, R F A, Love, A H G, Marsh, M, Mulder, C J J, Sjoberg, K, Stenhammer, L, Walker-Smith, J, Marossy, A M, and Houlston, R S

Published
1999

21. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Guideline development process for the updated guidelines

Author

Mihatsch, W, Shamir, R, van Goudoever, J B, Fewtrell, M, Lapillonne, A, Lohner, S, Mihályi, K, Decsi, T, ESPEN/ESPEN/ESPR/CSPEN working group, Braegger, C, et al, University of Zurich, and Mihatsch, W

Subjects
10036 Medical Clinic, 2916 Nutrition and Dietetics, 610 Medicine & health, 2706 Critical Care and Intensive Care Medicine
Published
2018
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30. NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease

Author

Schwerd, T, Bryant, R V, Pandey, S, Capitani, M, Meran, L, Cazier, J-B, Jung, J, Mondal, K, Parkes, M, Mathew, C G, Fiedler, K, McCarthy, D J, WGS500 Consortium, Oxford IBD cohort study investigators, COLORS in IBD group investigators, UK IBD Genetics Consortium, Sullivan, P B, Rodrigues, A, Travis, S P L, Moore, C, Sambrook, J, Ouwehand, W H, Roberts, D J, Danesh, J, INTERVAL Study, Russell, R K, Wilson, D C, Kelsen, J R, Cornall, R, Denson, L A, Braegger, C, et al, and University of Zurich

Subjects
2403 Immunology, 10036 Medical Clinic, 2723 Immunology and Allergy, 610 Medicine & health
Published
2018

32. Malignancy and mortality in paediatric-onset inflammatory bowel disease: a 3-year prospective, multinational study from the paediatric IBD Porto group of ESPGHAN

Author

Joosse, M. E. Aardoom, M. A. Kemos, P. Turner, D. and Wilson, D. C. Koletzko, S. Martin-de-Carpi, J. Fagerberg, U. L. Spray, C. Tzivinikos, C. Sladek, M. Shaoul, R. and Roma-Giannikou, E. Bronsky, J. Serban, D. E. Ruemmele, F. M. and Garnier-Lengline, H. Veres, G. Hojsak, I. Kolho, K. L. and Davies, I. H. Aloi, M. Lionetti, P. Hussey, S. and Veereman, G. Braegger, C. P. Trindade, E. Wewer, A. V. and Hauer, A. C. de Vries, A. C. H. Boneh, R. Sigall Shabat, C. Sarbagili Levine, A. de Ridder, L. Paediat IBD Porto Grp ESPGHAN

Subjects
digestive system diseases
Abstract

Background: Risk benefit strategies in managing inflammatory bowel diseases (IBD) are dependent upon understanding the risks of uncontrolled inflammation vs those of treatments. Malignancy and mortality in IBD have been associated with disease-related inflammation and immune suppression, but data are limited due to their rare occurrence. Aim: To identify and describe the most common causes of mortality, types of cancer and previous or current therapy among children and young adults with paediatric-onset IBD. Methods: Information on paediatric-onset IBD patients diagnosed with malignancy or mortality was prospectively collected via a survey in 25 countries over a 42-month period. Patients were included if death or malignancy occurred after IBD diagnosis but before the age of 26years. Results: In total, 60 patients were identified including 43 malignancies and 26 fatal cases (9 due to cancer). Main causes of fatality were malignancies (n=9), IBD or IBD-therapy related nonmalignant causes (n=10; including 5 infections), and suicides (n=3). Three cases, all fatal, of hepatosplenic T-cell lymphoma were identified, all were biologic-naive but thiopurine-exposed. No other haematological malignancies were fatal. The 6 other fatal cancer cases included 3 colorectal adenocarcinomas and 3 cholangiocarcinomas (CCAs). Primary sclerosing cholangitis (PSC) was present in 5 (56%) fatal cancers (1 colorectal carcinoma, 3 CCAs and 1 hepatosplenic T-cell lymphoma). Conclusions: We report the largest number of paediatric-onset IBD patients with cancer and/or fatal outcomes to date. Malignancies followed by infections were the major causes of mortality. We identified PSC as a significant risk factor for cancer-associated mortality. Disease-related adenocarcinomas were a commoner cause of death than lymphomas.

Published
2018

33. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Vitamins

Author

Bronsky, J., primary, Campoy, C., additional, Braegger, C., additional, Braegger, Christian, additional, Bronsky, Jiri, additional, Cai, Wei, additional, Campoy, Cristina, additional, Carnielli, Virgilio, additional, Darmaun, Dominique, additional, Decsi, Tamás, additional, Domellöf, Magnus, additional, Embleton, Nicholas, additional, Fewtrell, Mary, additional, Fidler Mis, Nataša, additional, Franz, Axel, additional, Goulet, Olivier, additional, Hartman, Corina, additional, Hill, Susan, additional, Hojsak, Iva, additional, Iacobelli, Silvia, additional, Jochum, Frank, additional, Joosten, Koen, additional, Kolaček, Sanja, additional, Koletzko, Berthold, additional, Ksiazyk, Janusz, additional, Lapillonne, Alexandre, additional, Lohner, Szimonetta, additional, Mesotten, Dieter, additional, Mihályi, Krisztina, additional, Mihatsch, Walter A., additional, Mimouni, Francis, additional, Mølgaard, Christian, additional, Moltu, Sissel J., additional, Nomayo, Antonia, additional, Picaud, Jean Charles, additional, Prell, Christine, additional, Puntis, John, additional, Riskin, Arieh, additional, Saenz De Pipaon, Miguel, additional, Senterre, Thibault, additional, Shamir, Raanan, additional, Simchowitz, Venetia, additional, Szitanyi, Peter, additional, Tabbers, Merit M., additional, Van Den Akker, Chris H.B., additional, Van Goudoever, Johannes B., additional, Van Kempen, Anne, additional, Verbruggen, Sascha, additional, Wu, Jiang, additional, and Yan, Weihui, additional

Published
2018
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34. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition : Vitamins

Author

Bronsky, J., Campoy, C., Braegger, C., Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Decsi, Tamas, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesuiten, Dieter, Mihalyi, Krisztina, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, John, Puntis, Arieh, Riskin, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Ver-Bruggen, Sascha, Wu, Jiang, Weihui, Yan, Bronsky, J., Campoy, C., Braegger, C., Braegger, Christian, Bronsky, Jiri, Cai, Wei, Campoy, Cristina, Carnielli, Virgilio, Darmaun, Dominique, Decsi, Tamas, Domellöf, Magnus, Embleton, Nicholas, Fewtrell, Mary, Fidler Mis, Natasa, Franz, Axel, Goulet, Olivier, Hartman, Corina, Hill, Susan, Hojsak, Iva, Iacobelli, Silvia, Jochum, Frank, Joosten, Koen, Kolacek, Sanja, Koletzko, Berthold, Ksiazyk, Janusz, Lapillonne, Alexandre, Lohner, Szimonetta, Mesuiten, Dieter, Mihalyi, Krisztina, Mihatsch, Walter A., Mimouni, Francis, Molgaard, Christian, Moltu, Sissel J., Nomayo, Antonia, Picaud, Jean Charles, Prell, Christine, John, Puntis, Arieh, Riskin, Saenz De Pipaon, Miguel, Senterre, Thibault, Shamir, Raanan, Simchowitz, Venetia, Szitanyi, Peter, Tabbers, Merit M., Van Den Akker, Chris H. B., Van Goudoever, Johannes B., Van Kempen, Anne, Ver-Bruggen, Sascha, Wu, Jiang, and Weihui, Yan

Abstract

Part: B

Published
2018
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36. Erkrankungen des Dickdarms

Author

Braegger, C P, University of Zurich, Speer, Christian P, Gahr, Manfred, Braegger, C, Speer, C, Gahr, M, and Braegger, C P

Subjects
10036 Medical Clinic, 610 Medicine & health
Published
2009

37. Malignancy and mortality in paediatric-onset inflammatory bowel disease

Author

Ridder, L., Joosse, M., Turner, D., Wilson, D., Koletzko, S., Martin-De-Carpi, J., Fagerberg, U., Spray, C., Sladek, M., Shaoul, R., Roma-Giannikou, E., Bronsky, J., Elena Daniela Serban, Cucchiara, S., Veres, G., Ruemmele, F., Hojsak, I., Kolho, K., Davies, I., Aloi, M., Lionetti, P., Veereman-Wauters, G., Braegger, C., Trindade, E., Wewer, A. V., Hauer, A., and Levine, A.

Published
2016

38. Documentation of functional and clinical effects of infant nutrition: setting the scene for COMMENT

Author

Koletzko B, Szajewska H, Ashwell M, Shamir R, Aggett P, Baerlocher K, Noakes P, Braegger C, Calder P, Campoy Folgoso C, Colomb V, Decsi T, Domellöf M, Dupont C, Fewtrell M, van Goudoever JB, Michaelsen KF, Mihatsch W, Koletzko S, Rigo J, Turck D, Taminiau J, Early Nutrition Academy, European Society for Paediatric Gastroenterology, Hepatology, Nutrition Committee on Nutrition – Consensus Group on Outcome Measures Made in Paediatric Enteral Nutrition Clinical T.r.i.a.l.s., GUARINO, ALFREDO, Pediatric surgery, ICaR - Circulation and metabolism, Koletzko, B, Szajewska, H, Ashwell, M, Shamir, R, Aggett, P, Baerlocher, K, Noakes, P, Braegger, C, Calder, P, Campoy Folgoso, C, Colomb, V, Decsi, T, Domellöf, M, Dupont, C, Fewtrell, M, van Goudoever, Jb, Michaelsen, Kf, Mihatsch, W, Guarino, Alfredo, Koletzko, S, Rigo, J, Turck, D, Taminiau, J, Early Nutrition, Academy, European Society for Paediatric Gastroenterology, Hepatology, Nutrition Committee on Nutrition – Consensus Group on Outcome Measures Made in Paediatric Enteral Nutrition Clinical, T. r. i. a. l. s., University of Zurich, Koletzko, Berthold, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), Paediatrics, and Paediatric Gastroenterology

Subjects
medicine.medical_specialty, MEDLINE, Nutritional Status, Medicine (miscellaneous), Guidelines as Topic, 610 Medicine & health, Documentation, Pediatrics, Enteral Nutrition, Humans, Medicine, Infant Nutritional Physiological Phenomena, Intensive care medicine, Nutrition and Dietetics, business.industry, Gastroenterology, Nutritional Requirements, Outcome measures, Infant, Foundation (evidence), 2701 Medicine (miscellaneous), Clinical trial, Parenteral nutrition, 10036 Medical Clinic, Child, Preschool, Family medicine, Reference Books, Medical, 2916 Nutrition and Dietetics, Energy Intake, business, Working group
Abstract

The Early Nutrition Academy and the Child Health Foundation, in collaboration with the Committee on Nutrition, European Society for Paediatric Gastroenterology, Hepatology and Nutrition, held a workshop in March 2011 to explore guidance on acquiring evidence on the effects of nutritional interventions in infants and young children. The four objectives were to (1) provide guidance on the quality and quantity of evidence needed to justify conclusions on functional and clinical effects of nutrition in infants and young children aged

Published
2012
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41. Prevalence of extraintestinal manifestations in paediatric patients with Inflammatory Bowel Disease : results from the Swiss IBD Cohort Study

Author

Vavricka, S., Rechner, R., Fournier, N., Rogler, G., Michetti, P., Pittet, V., Safroneeva, E., Straumann, A., Braegger, C., Nydegger, A., and Schoepfer, A.

Subjects
digestive system diseases
Abstract

Background: There is a paucity of data from large cohort studies on the prevalence and type of extraintestinal manifestations in pediatric patients with Crohn's disease (CD) and ulcerative colitis (UC). We aimed to assess the prevalence and type of EIM in pediatric patients with inflammatory bowel disease (IBD). Methods: Data from patients enrolled in the Pediatric Swiss IBD Cohort Study (P-SIBDCS) were analyzed. Since 2008 the P-SIBDCS collects data on patients aged 2-17 from hospitals and private practices across Switzerland. Results of continuous data are reported as median and interquartile range.

Published
2015

44. Laktoseintoleranz

Author

Braegger, C P, University of Zurich, and Braegger, C P

Subjects
10036 Medical Clinic, 610 Medicine & health
Published
2008

45. Iron Requirements of Infants And Toddlers : A Position Paper By The ESPGHAN Committee on Nutrition

Author

Domellöf, M., Braegger, C., Campoy, C., Colomb, V., Decsi, T., Fewtrell, M., Hojsak, Iva, Mihatsch, W., Molgaard, C., Shamir, R., Turck, D., and van Goudoever, J.

Subjects
iron
Abstract

Iron deficiency (ID) is the most common micronutrient deficiency worldwide and young children are a special risk group since their rapid growth leads to high iron requirements. Risk factors associated with a higher prevalence of iron deficiency anemia (IDA) include low birth weight, high cow's milk intake, low intake of iron-rich complementary foods, low socioeconomic status and immigrant status.The aim of this position paper is to review the field and provide recommendations regarding iron requirements in infants and toddlers, including those of moderately or marginally low birth weight.There is no evidence that iron supplementation of pregnant women improves iron status in their offspring in a European setting. Delayed cord clamping reduces the risk of iron deficiency. There is insufficient evidence to support general iron supplementation of healthy, European infants and toddlers of normal birth weight. Formula- fed infants up to 6 months of age should receive iron fortified infant formula, with an iron content of 4-8 mg/L (0.6-1.2 mg/kg/d). Marginally low birth weight infants (2000-2500 g) should receive iron supplements of 1-2 mg/kg/d. Follow-on formulas should be iron- fortified. However, there is not enough evidence to determine the optimal iron concentration in follow-on formula. From the age of 6 months, all infants and toddlers should receive iron-rich (complementary) foods including meat products and/or iron fortified foods. Unmodified cow's milk should not be fed as the main milk drink to infants before the age of 12 months and intake should be limited to

Published
2013
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46. Re: ESPGHAN's 2008 recommendation for early introduction of complementary foods: how good is the evidence? (Cattaneo et al. 2011)

Author

Shamir, R., Koletzko, B., Agostoni, C., Braegger, C., Campoy, C., Colomb, V., Domellöf, M., Decsi, T., Fewtrell, M., Goulet, O., Michaelsen, K.F., Kolaček, Sanja, Mihatsch, W., Moreno, L., Puntis, J., Rigo, J., Szajewska, H., Turck, D., van Goudoever, J.B., Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), Paediatrics, Pediatric surgery, ICaR - Circulation and metabolism, University of Zurich, and Shamir, Raanan

Subjects
10036 Medical Clinic, complementary foods, 2916 Nutrition and Dietetics, 610 Medicine & health, 2729 Obstetrics and Gynecology, 2735 Pediatrics, Perinatology and Child Health, 2739 Public Health, Environmental and Occupational Health
Abstract

Re: ESPGHAN's 2008 recommendation for early introduction of complementary foods: how good is the evidence? (Cattaneo et al. 2011).

Published
2012
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48. Systematic evaluation of risk factors for diagnostic delay in inflammatory bowel disease

Author

Vavricka, S R, Spigaglia, S M, Rogler, G, Pittet, V, Michetti, P, Felley, C, Mottet, C, Braegger, C P, Rogler, D, Straumann, A, Bauerfeind, P, Fried, M, Schoepfer, A M, University of Zurich, and Vavricka, S R

Subjects
10219 Clinic for Gastroenterology and Hepatology, 10036 Medical Clinic, 10076 Center for Integrative Human Physiology, 2723 Immunology and Allergy, 570 Life sciences, biology, 610 Medicine & health, 2715 Gastroenterology
Published
2011

49. Neue Wachstumskurven für die Schweiz

Author

Braegger, C, Jenni, O G, Konrad, D, Molinari, L, and University of Zurich

Subjects
10036 Medical Clinic, 610 Medicine & health
Published
2011

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