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1. Antimicrobial Peptide-Loaded Nanoparticles as Inhalation Therapy for Pseudomonas aeruginosa Infections

Author

Falciani C, Zevolini F, Brunetti J, Riolo G, Gracia R, Marradi M, Loinaz I, Ziemann C, Cossío U, Llop J, Bracci L, and Pini A

Subjects
antimicrobial peptides, nanoparticles, multi-drug resistance., Medicine (General), R5-920
Abstract

Chiara Falciani, 1 Fabrizia Zevolini, 1 Jlenia Brunetti, 1 Giulia Riolo, 2 Raquel Gracia, 3 Marco Marradi, 3 Iraida Loinaz, 3 Christina Ziemann, 4 Unai Cossío, 5 Jordi Llop, 5, 6 Luisa Bracci, 1 Alessandro Pini 1 1Department of Medical Biotechnologies, University of Siena, Siena, Italy; 2Setlance, Siena, Italy; 3CIDETEC, Basque Research and Technology Alliance (BRTA), Donostia-San Sebastián, Spain; 4Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany; 5CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), San Sebastian, Spain; 6Centro de Investigación Biomédica en red Enfermedades Respiratorias – CIBERES, Madrid, SpainCorrespondence: Chiara FalcianiDepartment of Medical Biotechnologies, University of Siena, via Aldo Moro 2, Siena, ItalyTel +39 0577 232022Email chiara.falciani@unisi.itIntroduction: Antibiotic-resistant bacteria kill 25,000 people every year in the EU. Patients subject to recurrent lung infections are the most vulnerable to severe or even lethal infections. For these patients, pulmonary delivery of antibiotics would be advantageous, since inhalation can achieve higher concentration in the lungs than iv administration and can provide a faster onset of action. This would allow for the delivery of higher doses and hence reduce the number of treatments required. We report here about a new nanosystem (M33-NS) obtained by capturing SET-M33 peptide on single-chain dextran nanoparticles. SET-M33 is a non-natural antimicrobial peptide synthesized in branched form. This form gives the peptide resistance to degradation in biological fluids. SET-M33 has previously shown efficacy in vitro against about one hundred of Gram-negative multidrug and extensively drug-resistant clinical isolates and was also active in preclinical infection models of pneumonia, sepsis and skin infections.Methods: The new nanosystem was evaluated for its efficacy in bacteria cells and in a mouse model of pneumonia. Toxicity and genotoxicity were also tested in vitro. Biodistribution and pharmacokinetic studies in healthy rats were carried out using a radiolabeled derivative of the nanosystem.Results: The M33-nanosystem, studied here, showed to be effective against Pseudomonas aeruginosa in time-kill kinetic experiments. Cytotoxicity towards different animal cell lines was acceptable. Lung residence time of the antimicrobial peptide, administered via aerosol in healthy rats, was markedly improved by capturing SET-M33 on dextran nanoparticles. M33-NS was also efficient in eradicating pulmonary infection in a BALB/c mouse model of pneumonia caused by P. aeruginosa.Discussion: This study revealed that the encapsulation of the antimicrobial peptide in dextran nanoparticles markedly improved lung residence time of the peptide administered via aerosol. The result has to be considered among the aims of the development of a new therapeutic option for patients suffering recurrent infections, that will benefit from high local doses of persistent antimicrobials.Keywords: antimicrobial peptides, nanoparticles, multi-drug resistance

Published
2020

3. Collisions of Muonic Atoms

Author

Bracci, L., Chiccoli, C., Florentine, G., Melezhik, V. S., Pasini, P., Wozniak, J., Zichichi, Antonino, editor, Simons, Leopold M., editor, Horváth, Dezsö, editor, and Torelli, Gabriele, editor

Published
1990
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5. Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models

Author

Ciccolella, M, Andreone, S, Mancini, J, Sestili, P, Negri, D, Pacca, AM, D'Urso, MT, Macchia, D, Canese, R, Pang, K, SaiYing Ko, T, Decadt, Y, Schiavoni, G, Mattei, F, Belardelli, F, Arico, E, Bracci, L, Ciccolella, M, Andreone, S, Mancini, J, Sestili, P, Negri, D, Pacca, AM, D'Urso, MT, Macchia, D, Canese, R, Pang, K, SaiYing Ko, T, Decadt, Y, Schiavoni, G, Mattei, F, Belardelli, F, Arico, E, and Bracci, L

Abstract

Salivary gland tumors are a heterogeneous group of neoplasms representing less than 10% of all head and neck tumors. Among salivary gland tumors, salivary duct carcinoma (SDC) is a rare, but highly aggressive malignant tumor resembling ductal breast carcinoma. Sublingual treatments are promising for SDC due to the induction of both local and systemic biological effects and to reduced systemic toxicity compared to other administration routes. In the present study, we first established that the sublingual administration of type I IFN (IFN-I) is safe and feasible, and exerts antitumor effects both as monotherapy and in combination with chemotherapy in transplantable tumor models, i.e., B16-OVA melanoma and EG.7-OVA lymphoma. Subsequently, we proved that sublingual IFN-I in combination with cyclophosphamide (CTX) induces a long-lasting reduction of tumor mass in NeuT transgenic mice that spontaneously develop SDC. Most importantly, tumor shrinkage in NeuT transgenic micewas accompanied by the emergence of tumor-specific cellular immune responses both in the blood and in the tumor tissue. Altogether, these results provide evidence that sublingual IFN holds promise in combination with chemotherapy for the treatment of cancer.

Published
2021

8. Human bone marrow mesenchymal stem cells and chondrocytes promote and/or suppress the in vitro proliferation of lymphocytes stimulated by proliferation of lymphocytes stimulated by interleukins 2, 7 and 15

Author

Bocelli-Tyndall, C., Bracci, L., Schaeren, S., Feder-Mengus, C., Barbero, A., Tyndall, A., and Spagnoli, G.C.

Subjects
Autoimmune diseases -- Development and progression, Autoimmune diseases -- Care and treatment, Autoimmune diseases -- Research, Cartilage cells -- Physiological aspects, Cartilage cells -- Research, Cell proliferation -- Physiological aspects, Cell proliferation -- Research, Interleukins -- Physiological aspects, Interleukins -- Research, Health
Published
2009

10. The commissioning of the central interferometer of the Virgo gravitational wave detector

Author

Acernese, F., Amico, P., Arnaud, N., Babusci, D., Barillé, R., Barone, F., Barsotti, L., Barsuglia, M., Beauville, F., Bizouard, M.A., Boccara, C., Bondu, F., Bosi, L., Bracci, L., Braccini, S., Bradaschia, C., Brillet, A., Brisson, V., Brocco, L., Buskulic, D., Calamai, G., Calloni, E., Campagna, E., Cavalier, F., Cella, G., Chassande-Mottin, E., Cleva, F., Cokelaer, T., Corda, C., Coulon, J.P., Cuoco, E., Dattilo, V., Davier, M., De Rosa, R., Di Fiore, L., Di Virgilio, A., Dujardin, B., Eleuteri, A., Enard, D., Ferrante, I., Fidecaro, F., Fiori, I., Flaminio, R., Fournier, J.D., Frasca, S., Frasconi, F., Gammaitoni, L., Gennai, A., Giazotto, A., Giordano, G., Guidi, G., Heitmann, H., Hello, P., Heusse, P., Holloway, L., Kreckelbergh, S., La Penna, P., Loriette, V., Losurdo, G., Loupias, M., Mackowski, J.M., Majorana, E., Man, C.N., Marion, F., Martelli, F., Masserot, A., Massonnet, L., Mazzoni, M., Milano, L., Moreau, F., Moreau, J., Morgado, N., Mornet, F., Mours, B., Pacheco, J., Pai, A., Palomba, C., Paoletti, F., Passaquieti, R., Passuello, D., Perniola, B., Pinard, L., Poggiani, R., Punturo, M., Puppo, P., Qipiani, K., Ramonet, J., Rapagnani, P., Reita, V., Remillieux, A., Ricci, F., Ricciardi, I., Russo, G., Solimeno, S., Stanga, R., Toncelli, A., Tonelli, M., Tournefier, E., Travasso, F., Trinquet, H., Varvella, M., Verkindt, D., Vetrano, F., Veziant, O., Viceré, A., Vinet, J.Y., Vocca, H., and Yvert, M.

Published
2004
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11. Lock acquisition of the central interferometer of the gravitational wave detector Virgo

Author

Acernese, F, Amico, P, Arnaud, N, Babusci, D, Barillé, R, Barone, F, Barsotti, L, Barsuglia, M, Beauville, F, Bizouard, M.A, Boccara, C, Bondu, F, Bosi, L, Bradaschia, C, Bracci, L, Braccini, S, Brillet, A, Brisson, V, Brocco, L, Buskulic, D, Calamai, G, Calloni, E, Campagna, E, Cavalier, F, Cella, G, Chassande-Mottin, E, Cleva, F, Cokelaer, T, Corda, C, Coulon, J.-P, Cuoco, E, Dattilo, V, Davier, M, De Rosa, R, Di Fiore, L, Di Virgilio, A, Dujardin, B, Eleuteri, A, Enard, D, Ferrante, I, Fidecaro, F, Fiori, I, Flaminio, R, Fournier, J.-D, Frasca, S, Frasconi, F, Gammaitoni, L, Gennai, A, Giazotto, A, Giordano, G, Guidi, G, Heitmann, H, Hello, P, Heusse, P, Holloway, L, Kreckelbergh, S, La Penna, P, Loriette, V, Loupias, M, Losurdo, G, Mackowski, J.-M, Majorana, E, Man, C.N, Marion, F, Martelli, F, Masserot, A, Massonnet, L, Mazzoni, M, Milano, L, Moreau, J, Moreau, F, Morgado, N, Mornet, F, Mours, B, Pacheco, J, Pai, A, Palomba, C, Paoletti, F, Passaquieti, R, Passuello, D, Perniola, B, Pinard, L, Poggiani, R, Punturo, M, Puppo, P, Qipiani, K, Ramonet, J, Rapagnani, P, Reita, V, Remillieux, A, Ricci, F, Ricciardi, I, Russo, G, Solimeno, S, Stanga, R, Toncelli, A, Tonelli, M, Tournefier, E, Travasso, F, Trinquet, H, Varvella, M, Verkindt, D, Vetrano, F, Veziant, O, Viceré, A, Vinet, J.-Y, Vocca, H, and Yvert, M

Published
2004
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12. First locking of the Virgo central area interferometer with suspension hierarchical control

Author

Acernese, F, Amico, P, Arnaud, N, Babusci, D, Barillé, R, Barone, F, Barsotti, L, Barsuglia, M, Beauville, F, Bizouard, M.A, Boccara, C, Bondu, F, Bosi, L, Bradaschia, C, Bracci, L, Braccini, S, Brillet, A, Brisson, V, Brocco, L, Buskulic, D, Calamai, G, Calloni, E, Campagna, E, Cavalier, F, Cella, G, Chassande-Mottin, E, Cleva, F, Cokelaer, T, Conforto, G, Corda, C, Coulon, J.-P, Cuoco, E, Dattilo, V, Davier, M, De Rosa, R, Di Fiore, L, Di Virgilio, A, Dujardin, B, Eleuteri, A, Enard, D, Ferrante, I, Fidecaro, F, Fiori, I, Flaminio, R, Fournier, J.-D, Frasca, S, Frasconi, F, Gammaitoni, L, Gennai, A, Giazotto, A, Giordano, G, Guidi, G, Heitmann, H, Hello, P, Heusse, P, Holloway, L, Kreckelberg, S, La Penna, P, Loriette, V, Loupias, M, Losurdo, G, Mackowski, J.-M, Majorana, E, Man, C.N, Marion, F, Martelli, F, Masserot, A, Massonnet, L, Mazzoni, M, Milano, L, Moreau, J, Moreau, F, Morgado, N, Mornet, F, Mours, B, Pacheco, J, Pai, A, Palomba, C, Paoletti, F, Passaquieti, R, Passuello, D, Perniola, B, Pinard, L, Poggiani, R, Punturo, M, Puppo, P, Qipiani, K, Ramonet, J, Rapagnani, P, Reita, V, Remillieux, A, Ricci, F, Ricciardi, I, Russo, G, Solimeno, S, Stanga, R, Toncelli, A, Tonelli, M, Tournefier, E, Travasso, F, Trinquet, H, Varvella, M, Verkindt, D, Vetrano, F, Veziant, O, Viceré, A, Vinet, J.-Y, Vocca, H, and Yvert, M

Published
2004
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13. A local control system for the test masses of the Virgo gravitational wave detector

Author

Acernese, F, Amico, P, Arnaud, N, Babusci, D, Barillé, R, Barone, F, Barsotti, L, Barsuglia, M, Beauville, F, Bizouard, M.A, Boccara, C, Bondu, F, Bosi, L, Bradaschia, C, Bracci, L, Braccini, S, Brillet, A, Brisson, V, Brocco, L, Buskulic, D, Calamai, G, Calloni, E, Campagna, E, Cavalier, F, Cella, G, Chassande-Mottin, E, Cleva, F, Cokelaer, T, Conforto, G, Corda, C, Coulon, J.-P, Cuoco, E, Dattilo, V, Davier, M, De Rosa, R, Di Fiore, L, Di Virgilio, A, Dujardin, B, Eleuteri, A, Enard, D, Ferrante, I, Fidecaro, F, Fiori, I, Flaminio, R, Fournier, J.-D, Frasca, S, Frasconi, F, Gammaitoni, L, Gennai, A, Giazotto, A, Giordano, G, Guidi, G, Heitmann, H, Hello, P, Heusse, P, Holloway, L, Kreckelbergh, S, La Penna, P, Loriette, V, Loupias, M, Losurdo, G, Mackowski, J.-M, Majorana, E, Man, C.N, Marion, F, Martelli, F, Masserot, A, Massonnet, L, Mazzoni, M, Milano, L, Moreau, J, Moreau, F, Morgado, N, Mornet, F, Mours, B, Pacheco, J, Pai, A, Palomba, C, Paoletti, F, Passaquieti, R, Passuello, D, Perniola, B, Pinard, L, Poggiani, R, Punturo, M, Puppo, P, Qipiani, K, Ramonet, J, Rapagnani, P, Reita, V, Remillieux, A, Ricci, F, Ricciardi, I, Russo, G, Solimeno, S, Stanga, R, Toncelli, A, Tonelli, M, Tournefier, E, Travasso, F, Trinquet, H, Varvella, M, Verkindt, D, Vetrano, F, Veziant, O, Viceré, A, Vinet, J.-Y, Vocca, H, and Yvert, M

Published
2004
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21. Investigations into the killing activity of an antimicrobial peptide active against extensively antibiotic-resistant K. pneumon iae and P. aeruginosa

Author

Weide, H. (Hessel) van der, Brunetti, J. (Jlenia), Pini, A. (Alessandro), Bracci, L. (Luisa), Ambrosini, C. (Chiara), Lupetti, P. (Pietro), Paccagnini, E. (Eugenio), Gentile, M. (Mariangela), Bernini, A. (Andrea), Niccolai, N. (Neri), Vermeulen-de Jongh, D.M.C. (Denise), Bakker-Woudenberg, I.A.J.M. (Irma), Goessens, W.H.F. (Wil), Hays, J.P. (John), Falciani, C. (Chiara), Weide, H. (Hessel) van der, Brunetti, J. (Jlenia), Pini, A. (Alessandro), Bracci, L. (Luisa), Ambrosini, C. (Chiara), Lupetti, P. (Pietro), Paccagnini, E. (Eugenio), Gentile, M. (Mariangela), Bernini, A. (Andrea), Niccolai, N. (Neri), Vermeulen-de Jongh, D.M.C. (Denise), Bakker-Woudenberg, I.A.J.M. (Irma), Goessens, W.H.F. (Wil), Hays, J.P. (John), and Falciani, C. (Chiara)

Abstract

SET-M33 is a multimeric antimicrobial peptide active against Gram-negative bacteria _in vitro_ and _in vivo_. Insights into its killing mechanism could elucidate correlations with selectivity. SET-M33 showed concentration-dependent bactericidal activity against colistin-susceptible and resistant isolates of _P. aeruginosa_ and _K. pneumoniae_. Scanning and transmission microscopy studies showed that SET-M33 generated cell blisters, blebs, membrane stacks and deep craters in _K.

Published
2017
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22. Investigations into the killing activity of an antimicrobial peptide active against extensively antibiotic-resistant K-pneumon iae and P-aeruginosa

Author

Weide, Hessel, Brunetti, J, Pini, A, Bracci, L, Ambrosini, C, Lupetti, P, Paccagnini, E, Gentile, M, Bernini, A, Niccolai, N, Vermeulen-de Jongh, D, Woudenberg, Irma, Goessens, Wil, Hays, John, Falciani, C, Weide, Hessel, Brunetti, J, Pini, A, Bracci, L, Ambrosini, C, Lupetti, P, Paccagnini, E, Gentile, M, Bernini, A, Niccolai, N, Vermeulen-de Jongh, D, Woudenberg, Irma, Goessens, Wil, Hays, John, and Falciani, C

Published
2017

26. Classification of current anticancer immunotherapies

Author

Galluzzi, L, Vacchelli, E, Bravo-San Pedro, J, Buqué, A, Senovilla, L, Baracco, E, Bloy, N, Castoldi, F, Abastado, J, Agostinis, P, Apte, R, Aranda, F, Ayyoub, M, Beckhove, P, Blay, J, Bracci, L, Caignard, A, Castelli, C, Cavallo, F, Celis, E, Cerundolo, V, Clayton, A, Colombo, M, Coussens, L, and Dhodapkar, M

Abstract

During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into "passive" and "active" based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification does not properly reflect the complexity of the drug-host-tumor interaction. Alternatively, anticancer immunotherapeutics can be classified according to their antigen specificity. While some immunotherapies specifically target one (or a few) defined tumor-associated antigen(s), others operate in a relatively non-specific manner and boost natural or therapy-elicited anticancer immune responses of unknown and often broad specificity. Here, we propose a critical, integrated classification of anticancer immunotherapies and discuss the clinical relevance of these approaches.

Published
2016

27. Efficient stimulation of T cell responses by human IFN-alpha-induced dendritic cells does not require Toll-like receptor triggering

Author

Bracci, L, Schumacher, R, Provenzano, M, Adamina, M, Rosenthal, R, Groeper, C, Zajac, P, Iezzi, G, Proietti, E, Belardelli, F, Spagnoli, G C, University of Zurich, and Bracci, L

Subjects
10062 Urological Clinic, 2403 Immunology, 10022 Division of Surgical Research, 3004 Pharmacology, 2723 Immunology and Allergy, 610 Medicine & health, 1306 Cancer Research
Published
2008
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28. Systemic lupus erythematosus in Europe at the change of the millennium: lessons from the 'Euro-Lupus Project'

Author

Cervera, R, ABARCA-COSTALAGO, M, Abramovicz, D, Allegri, F, Annunziata, P, Aydintug, Ao, Bacarelli, Mr, Bellisai, F, Bernardino, I, BIERNAT-KALUZA, E, Blockmans, D, Boki, K, Bracci, L, Campanella, V, Camps, Mt, Carcassi, C, Cattaneo, R, Cauli, A, CHWALINSKA-SADOWSKA, H, Contu, L, Cosyns, Jp, Danieli, Mg, Dcruz, D, Depresseux, G, Direskeneli, H, Domenech, I, Espinosa, G, FERNANDEZ-NEBRO, A, Ferrara, Gb, Font, J, Frutos, Ma, Galeazzi, M., GARCIA-CARRASCO, M, GARCIA IGLESIAS MF, GARCIA-TOBARUELA, A, George, J, Gil, A, GONZALEZ-SANTOS, P, Grana, M, Gul, A, Haga, Hj, DE HARO-LIGER, M, Houssiau, F, Hughes, Gr, Ingelmo, M, JEDRYKA-GORAL, A, Khamashta, Ma, Lavilla, P, Levi, Y, LOPEZ-DULPA, M, LOPEZ-SOTO, A, Maldykowa, H, Marcolongo, R, Mathieu, A, Morozzi, G, Nicolopoulou, N, Papasteriades, C, Passiu, G, Perello, I, Petera, P, Petrovic, R, Piette, Jc, Pintado, V, DE PITA, O, Popovic, R, Pucci, G, Puddu, P, DE RAMON, E, RAMOS-CASALS, M, RODRIGUEZ-ANDREU, J, RUIZ-IRASTORZA, G, SANCHEZ-LORA, J, Sanna, G, Scorza, R, Sebastiani, Gd, Sherer, Y, Shoenfeld, Y, Simpatico, A, Sinico, Ra, Smolen, J, Tincani, A, Tokgoz, G, URBANO-MARQUEZ, A, Vasconcelos, C, Vazquez, Jj, Veronesi, J, Vianna, J, Vivancos, J, UCL - MD/MINT - Département de médecine interne, UCL - (SLuc) Service de rhumatologie, UCL - MD/MNOP - Département de morphologie normale et pathologique, UCL - (SLuc) Service d'anatomie pathologique, Cervera, R, Abarca Costalago, M, Abramovicz, D, Allegri, F, Annunziata, P, Aydintug, A, Bacarelli, M, Bellisai, F, Bernardino, I, Biernat Kaluza, E, Blockmans, D, Boki, K, Bracci, L, Campanella, V, Camps, M, Carcassi, C, Cattaneo, R, Cauli, A, Chwalinska Sadowska, H, Contu, L, Cosyns, J, Danieli, M, D́cruz, D, Depresseux, G, Direskeneli, H, Domènech, I, Espinosa, G, Fernández Nebro, A, Ferrara, G, Font, J, Frutos, M, Galeazzi, M, García Carrasco, M, García Iglesias, M, García Tobaruela, A, George, J, Gil, A, González Santos, P, Grana, M, Gül, A, Haga, H, de Haro Liger, M, Houssiau, F, Hughes, G, Ingelmo, M, Jedryka Góral, A, Khamashta, M, Lavilla, P, Levi, Y, López Dupla, M, López Soto, A, Maldykowa, H, Marcolongo, R, Mathieu, A, Morozzi, G, Nicolopoulou, N, Papasteriades, C, Passiu, G, Perelló, I, Petera, P, Petrovic, R, Piette, J, Pintado, V, de Pita, O, Popovic, R, Pucci, G, Puddu, P, de Ramón, E, Ramos Casals, M, Rodríguez Andreu, J, Ruiz Irastorza, G, Sánchez Lora, J, Sanna, G, Scorza, R, Sebastiani, G, Sherer, Y, Shoenfeld, Y, Simpatico, A, Sinico, R, Smolen, J, Tincani, A, Tokgöz, G, Urbano Márquez, A, Vasconcelos, C, Vázquez, J, Veronesi, M, Vianna, J, and Vivancos, J

Subjects
Male, medicine.medical_specialty, Prognosi, Epidemiology, Immunology, Systemic lupus erythematosu, Disease, Prognostic factors, Autoimmune Disease, Follow-Up Studie, Autoimmune Diseases, Cohort Studies, Systemic lupus erythematosus, immune system diseases, medicine, Immunology and Allergy, Humans, Lupus Erythematosus, Systemic, Prospective Studies, Age of Onset, Mortality, Prospective cohort study, skin and connective tissue diseases, Survival rate, Prognostic factor, business.industry, medicine.disease, Prognosis, Europe, Survival Rate, Prospective Studie, Family medicine, Antibodies, Antinuclear, Cohort, Female, Cohort Studie, Age of onset, Morbidity, business, Human, Cohort study, Follow-Up Studies
Abstract

The "Euro-Lupus Cohort" is composed by 1000 patients with systemic lupus erythematosus (SLE) that have been followed prospectively since 1991. These patients have been gathered by a European consortium-the "Euro-Lupus Project Group". This consortium was originated as part of the network promoted by the "European Working Party on SLE", a working group created in 1990 in order to promote research in Europe on the different problems related to this disease. The "Euro-Lupus Cohort" provides an updated information on the SLE morbidity and mortality characteristics in the present decade as well as defines several clinical and immunological prognostic factors. © 2005 Elsevier B.V. All rights reserved.

Published
2006

40. Consensus guidelines for the detection of immunogenic cell death

Author

Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., Bracci, L., Breckpot, K., Brough, D., Buqué, A., Castro, Mg, Cirone, M., Colombo, Mi, Cremer, I., Demaria, S., Dini, L., Eliopoulos, A., Faggioni, A., Formenti, Sc, Fu??íková, J., Gabriele, L., Gaipl, Us, Galon, J., Garg, A., Ghiringhelli, F., Giese, Na, Guo, Zs, Hemminki, A., Herrmann, M., Hodge, Jw, Holdenrieder, S., Honeychurch, J., Hm, Hu, Huang, X., Illidge, Tm, Kono, K., Korbelik, M., Krysko, Dv, Loi, S., Lowenstein, Pr, Lugli, E., Ma, Y., Madeo, F., Manfredi, Aa, Martins, I., Matzinger, P., Mavilio, D., Menger, L., Merendino, N., Michaud, M., Mignot, G., Mossman, Kl, Multhoff, G., Oehler, R., Palombo, F., Panaretakis, T., Pol, J., Proietti, E., Ricci, Je, Riganti, Chiara, Rovere Querini, P., Rubartelli, A., Sistigu, A., Smyth, Mj, Sonnemann, J., Spisek, R., Stagg, J., Sukkurwala, Aq, Tartour, E., Thorburn, A., Thorne, Sh, Vandenabeele, P., Velotti, F., Workenhe, Sr, Yang, H., Zong, Wx, Zitvogel, L., Kroemer, G., Galluzzi, L., Medicine and Pharmacy academic/administration, Basic (bio-) Medical Sciences, Laboratory of Molecullar and Cellular Therapy, Chemistry, Kepp, Oliver, Senovilla, Laura, Vitale, Ilio, Vacchelli, Erika, Adjemian, Sandy, Agostinis, Patrizia, Apetoh, Lionel, Aranda, Fernando, Barnaba, Vincenzo, Bloy, Norma, Bracci, Laura, Breckpot, Karine, Brough, David, Buqué, Aitziber, Castro, Maria G, Cirone, Mara, Colombo, Maria I, Cremer, Isabelle, Demaria, Sandra, Dini, Luciana, Eliopoulos, Aristides G, Faggioni, Alberto, Formenti, Silvia C, Fučíková, Jitka, Gabriele, Lucia, Gaipl, Udo S, Galon, Jérôme, Garg, Abhishek, Ghiringhelli, Françoi, Giese, Nathalia A, Guo, Zong Sheng, Hemminki, Akseli, Herrmann, Martin, Hodge, James W, Holdenrieder, Stefan, Honeychurch, Jamie, Hu, Hong Min, Huang, Xing, Illidge, Tim M, Kono, Koji, Korbelik, Mladen, Krysko, Dmitri V, Loi, Sherene, Lowenstein, Pedro R, Lugli, Enrico, Ma, Yuting, Madeo, Frank, Manfredi, Angelo A, Martins, Isabelle, Mavilio, Domenico, Menger, Laurie, Merendino, Nicolò, Michaud, Michael, Mignot, Gregoire, Mossman, Karen L, Multhoff, Gabriele, Oehler, Rudolf, Palombo, Fabio, Panaretakis, Theochari, Pol, Jonathan, Proietti, Enrico, Ricci, Jean Ehrland, Riganti, Chiara, Rovere Querini, Patrizia, Rubartelli, Anna, Sistigu, Antonella, Smyth, Mark J, Sonnemann, Juergen, Spisek, Radek, Stagg, John, Sukkurwala, Abdul Qader, Tartour, Eric, Thorburn, Andrew, Thorne, Stephen H, Vandenabeele, Peter, Velotti, Francesca, Workenhe, Samuel T, Yang, Haining, Zong, Wei Xing, Zitvogel, Laurence, Kroemer, Guido, Galluzzi, Lorenzo, Kepp, O, Senovilla, L, Vitale, I, Vacchelli, E, Adjemian, S, Agostinis, P, Apetoh, L, Aranda, F, Barnaba, V, Bloy, N, Bracci, L, Breckpot, K, Brough, D, Buque, A, Castro, Mg, Cirone, M, Colombo, Mi, Cremer, I, Demaria, S, Dini, L, Eliopoulos, Ag, Faggioni, A, Formenti, Sc, Fucikova, J, Gabriele, L, Gaipl, U, Galon, J, Garg, A, Ghiringhelli, F, Giese, Na, Guo, Z, Hemminki, A, Herrmann, M, Hodge, Jw, Holdenrieder, S, Honeychurch, J, Hu, Hm, Huang, X, Illidge, Tm, Kono, K, Korbelik, M, Krysko, Dv, Loi, S, Lowenstein, Pr, Lugli, E, Ma, Yt, Madeo, F, Manfredi, ANGELO ANDREA M. A., Martins, I, Mavilio, D, Menger, L, Merendino, N, Michaud, M, Mignot, G, Mossman, Kl, Multhoff, G, Oehler, R, Palombo, F, Panaretakis, T, Pol, J, Proietti, E, Ricci, Je, Riganti, C, ROVERE QUERINI, Patrizia, Rubartelli, A, Sistigu, A, Smyth, Mj, Sonnemann, J, Spisek, R, Stagg, J, Sukkurwala, Aq, Tartour, E, Thorburn, A, Thorne, Sh, Vandenabeele, P, Velotti, F, Workenhe, St, Yang, Hn, Zong, Wx, Zitvogel, L, Kroemer, G, and Galluzzi, L.

Subjects
HSV-1, herpes simplex virus type I, Δψm, mitochondrial transmembrane potential, medicine.medical_treatment, DAMP, damage-associated molecular pattern, detection, FLT3LG, fms-related tyrosine kinase 3 ligand, Review, member 3, calreticulin, Eukaryotic translation initiation factor 2A, RFP, red fluorescent protein, 0302 clinical medicine, MOMP, mitochondrial outer membrane permeabilization, Immunology and Allergy, GFP, green fluorescent protein, HMGB1, 0303 health sciences, education.field_of_study, Toll-like receptor, BAK1, BCL2-antagonist/killer 1, H2B, histone 2B, endoplasmic reticulum stre, 3. Good health, BAX, BCL2-associated X protein, XBP1, X-box binding protein 1, cell death, Oncology, PDIA3, protein disulfide isomerase family A, 030220 oncology & carcinogenesis, endoplasmic reticulum stress, Immunogenic cell death, HSP, heat shock protein, immunotherapy, TLR, Toll-like receptor, autophagy, ATF6, activating transcription factor 6, Immunology, ICD, immunogenic cell death, EIF2A, eukaryotic translation initiation factor 2A, Guidelines, Biology, BCL2, B-cell CLL/lymphoma 2 protein, ER, endoplasmic reticulum, PI, propidium iodide, ATP release, 03 medical and health sciences, Immune system, immunogenic, medicine, IFN, interferon, Antigen-presenting cell, education, 030304 developmental biology, CALR, calreticulin, Damage-associated molecular pattern, Immunotherapy, CTL, cytotoxic T lymphocyte, HMGB1, high mobility group box 1, IL, interleukin, G3BP1, GTPase activating protein (SH3 domain) binding protein 1, APC, antigen-presenting cell, Cancer cell, DiOC6(3), 3,3′-dihexyloxacarbocyanine iodide, DAPI, 4′,6-diamidino-2-phenylindole
Abstract

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named "immunogenic cell death" (ICD). ICD is preceded or accompanied by the emission of a series of immunostimulatory damage-associated molecular patterns (DAMPs) in a precise spatiotemporal configuration. Several anticancer agents that have been successfully employed in the clinic for decades, including various chemotherapeutics and radiotherapy, can elicit ICD. Moreover, defects in the components that underlie the capacity of the immune system to perceive cell death as immunogenic negatively influence disease outcome among cancer patients treated with ICD inducers. Thus, ICD has profound clinical and therapeutic implications. Unfortunately, the gold-standard approach to detect ICD relies on vaccination experiments involving immunocompetent murine models and syngeneic cancer cells, an approach that is incompatible with large screening campaigns. Here, we outline strategies conceived to detect surrogate markers of ICD in vitro and to screen large chemical libraries for putative ICD inducers, based on a high-content, high-throughput platform that we recently developed. Such a platform allows for the detection of multiple DAMPs, like cell surface-exposed calreticulin, extracellular ATP and high mobility group box 1 (HMGB1), and/or the processes that underlie their emission, such as endoplasmic reticulum stress, autophagy and necrotic plasma membrane permeabilization. We surmise that this technology will facilitate the development of next-generation anticancer regimens, which kill malignant cells and simultaneously convert them into a cancer-specific therapeutic vaccine. peerreview_statement: The publishing and review policy for this title is described in its Aims & Scope. aims_and_scope_url: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=koni20 ispartof: OncoImmunology vol:3 issue:9 pages:12472-124508 ispartof: location:United States status: published

Published
2014
Full Text
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46. European Working Party on Systemic Lupus Erythematosus. Systemic lupus erythematosus in Europe at the change of the millennium: lessons from the 'Euro-Lupus Project'

Author

Cervera, R, ABARCA COSTALAGO, M, Abramovicz, D, Allegri, F, Annunziata, P, Aydintug, Ao, Bacarelli, Mr, Bellisai, F, Bernardino, I, BIERNAT KALUZA, E, Blockmans, D, Boki, K, Bracci, L, Campanella, V, Camps, Mt, Carcassi, C, Cattaneo, Roberto, Cauli, A, CHWALINSKA SADOWSKA, H, Contu, L, Cosyns, Jp, Danieli, Mg, Dcruz, D, Depresseux, G, Direskeneli, H, Domènech, I, Espinosa, G, FERNÁNDEZ NEBRO, A, Ferrara, Gb, Font, J, Frutos, Ma, Galeazzi, M, GARCÌA CARRASCO, M, GARCÍA IGLESIAS MF, GARCÍA TOBARUELA, A, George, J, Gil, A, GONZÁLEZ SANTOS, P, Grana, M, Gül, A, Haga, Hj, DE HARO LIGER, M, Houssiau, F, Hughes, Gr, Ingelmo, M, JEDRYKA GÓRAL, A, Khamashta, Ma, Lavilla, P, Levi, Y, LÓPEZ DULPA, M, LÓPEZ SOTO, A, Maldykowa, H, Marcolongo, R, Mathieu, A, Morozzi, G, Nicolopoulou, N, Papasteriades, C, Passiu, G, Perelló, I, Petera, P, Petrovic, R, Piette, Jc, Pintado, V, DE PITA, O, Popovic, R, Pucci, G, Puddu, P, DE RAMÓN, E, RAMOS CASALS, M, RODRÍGUEZ ANDREU, J, RUIZ IRASTORZA, G, SANCHEZ LORA, J, Sanna, G, Scorza, R, Sebastiani, Gd, Sherer, Y, Shoenfeld, Y, Simpatico, A, Sinico, Ra, Smolen, J, Tincani, Angela, Tokgöz, G, URBANO MÁRQUEZ, A, Vasconcelos, C, Vázquez, Jj, Veronesi, J, Vianna, J, and Vivancos, J.

Published
2006

48. Search for inspiralling binary events in the Virgo engineering run data

Author

Acernese , F., Amico , P., Arnaud , N., Babusci , D., Barill , R., Barone , F., Barsotti , L., Barsuglia , M., Beauville , F., Boccara , C., Bondu , F., Bosi , L., Bradaschia , C., Bracci , L., Braccini , S., Brillet , A., Brisson , V., Brocco , L., Buskulic , D., Calamai , G., Calloni , E., Campagna , E., Cavalier , F., Cella , G., Chassande-Mottin , E., Cleva , F., Cokelaer , T., Conforto , G., Corda , C., Coulon , J.-P., Cuoco , E., Dattilo , V., Davier , M., De Rosa , R., Di Fiore , L., Di Virgilio , A., Dujardin , B., Eleuteri , A., Enard , D., Ferrante , I., Fidecaro , F., Fiori , I., Flaminio , R., Fournier , J-D., Frasca , S., Frasconi , F., Gammaitoni , L., Gennai , A., Giazotto , A., Giordano , G., Guidi , G., Heitmann , H., Hello , P., Heusse , P., Holloway , L., Kreckelberg , S., La Penna , P., Loriette , V., Loupias , M., Losurdo , G., Mackowski , J.-M., Majorana , E., Marion , F., Martelli , F., Masserot , A., Massonnet , L., Mazzoni , M., Milano , L., Moreau , Julien, Moreau , F., Morgado , N., Mornet , F., Mours , B., Pacheco , J., Pai , A., Palomba , C., Paoletti , F., Passaquieti , R., Passuello , D., Perniola , B., Pinard , L., Poggiani , R., Punturo , M., Puppo , P., Qipiani , K., Ramonet , J., Rapagnani , P., Reita , V., Remillieux , A., Ricci , F., Ricciardi , I., Russo , G., Solimeno , S., Stanga , R., Toncelli , A., Tonelli , M., Tournefier , E., Travasso , F., Trinquet , H., Varvella , M., Verkindt , D., Vetrano , F., Veziant , O., Vicer , A., Vinet , J.-Y., Vocca , M., Yvert , M., Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire des matériaux avancés (LMA), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, VIRGO, Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Annecy de Physique des Particules ( LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des matériaux avancés ( LMA ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), and Flores, Sylvie

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], [PHYS.ASTR.CO] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [SDU.ASTR] Sciences of the Universe [physics]/Astrophysics [astro-ph], [ PHYS.ASTR.CO ] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [ SDU.ASTR ] Sciences of the Universe [physics]/Astrophysics [astro-ph]
Published
2004

49. Status of VIRGO

Author

Acernese, Fausto, Amico, P., Arnaud, N., Babusci, D., Barillé, R., Barone, Fabrizio, Barsotti, L., Barsuglia, M., Beauville, F., Bizouard, M. A., Boccara, C., Bondu, F., Bosi, L., Bradaschia, C., Bracci, L., Braccini, S., Brillet, A., Brisson, V., Brocco, L., Buskulic, D., Calamai, G., Calloni, E., Campagna, E., Cavalier, F., Cella, G., Chassande Mottin, E., Cleva, F., Cokelaer, T., Conforto, G., Corda, C., Coulon, J. P., Cuoco, E., Dattilo, V., Davier, M., De Rosa, R., Di Fiore, L., Di Virgilio, A., Dujardin, B., Eleuteri, A., Enard, D., Ferrante, I., Fidecaro, F., Fiori, I., Flaminio, R., Fournier, J. D., Frasca, S., Frasconi, F., Gammaitoni, L., Gennai, A., Giazotto, A., Giordano, G., Guidi, G., Heitmann, H., Hello, P., Heusse, P., Holloway, L., Kreckelberg, S., La Penna, P., Loriette, V., Loupias, M., Losurdo, G., Mackowski, J. M., Majorana, E., Man, C. N., Marion, F., Martelli, F., Masserot, A., Massonnet, L., Mazzoni, M., Milano, L., Moreau, J., Moreau, F., Morgado, N., Mornet, F., Mours, B., Pacheco, J., Pai, A., Palomba, C., Paoletti, F., Passaquieti, R., Passuello, D., Perniola, B., Pinard, L., Poggiani, R., Punturo, M., Puppo, P., Qipiani, K., Ramonet, J., Rapagnani, P., Reita, V., Remillieux, A., Ricci, F., Ricciardi, I., Russo, G., Solimeno, S., Stanga, R., Toncelli, A., Tonelli, M., Tournefier, E., Travasso, F., Trinquet, H., Varvella, M., Verkindt, D., Vetrano, F., Veziant, O., Viceré, A., Vinet, J. Y., Vocca, H., Yvert, M., F., Acernese, P., Amico, N., Arnaud, D., Babusci, R., Barillé, F., Barone, L., Barsotti, M., Barsuglia, F., Beauville, M. A., Bizouard, C., Boccara, F., Bondu, L., Bosi, C., Bradaschia, L., Bracci, S., Braccini, A., Brillet, V., Brisson, L., Brocco, D., Buskulic, G., Calamai, Calloni, Enrico, E., Campagna, F., Cavalier, G., Cella, E., Chassande Mottin, F., Cleva, T., Cokelaer, G., Conforto, C., Corda, J. P., Coulon, E., Cuoco, V., Dattilo, M., Davier, DE ROSA, Rosario, L., Di Fiore, A., Di Virgilio, B., Dujardin, A., Eleuteri, D., Enard, I., Ferrante, F., Fidecaro, I., Fiori, R., Flaminio, J. D., Fournier, S., Frasca, F., Frasconi, L., Gammaitoni, A., Gennai, A., Giazotto, G., Giordano, G., Guidi, H., Heitmann, P., Hello, P., Heusse, L., Holloway, S., Kreckelberg, P., La Penna, V., Loriette, M., Loupia, G., Losurdo, J. M., Mackowski, E., Majorana, C. N., Man, F., Marion, F., Martelli, A., Masserot, L., Massonnet, M., Mazzoni, L., Milano, J., Moreau, F., Moreau, N., Morgado, F., Mornet, B., Mour, J., Pacheco, A., Pai, C., Palomba, F., Paoletti, R., Passaquieti, D., Passuello, B., Perniola, L., Pinard, R., Poggiani, M., Punturo, P., Puppo, K., Qipiani, J., Ramonet, P., Rapagnani, V., Reita, A., Remillieux, F., Ricci, I., Ricciardi, Russo, Guido, S., Solimeno, R., Stanga, A., Toncelli, M., Tonelli, E., Tournefier, F., Travasso, H., Trinquet, M., Varvella, D., Verkindt, F., Vetrano, O., Veziant, A., Viceré, J. Y., Vinet, H., Vocca, and M., Yvert

Subjects
Gravitational wave detectors and experiments, Interferometers, Physics and Astronomy (miscellaneous)
Published
2004

50. A First Test of a Sine-Hough Method for Detection of Pulsars in Binary Systems using the E4 Virgo Test Run Data

Author

Michel, Yvert, Acernese, Fausto, Amico, P., Arnaud, N., Babusci, D., Barillé, R., Barone, Fabrizio, Barsotti, L., Barsuglia, M., Beauville, F., Bizouard, M. A., Boccara, C., Bondu, F., Bosi, L., Bradaschia, C., Bracci, L., Braccini, S., Brillet, A., Brisson, V., Brocco, L., Buskulic, D., Calamai, G., Calloni, E., Campagna, E., Cavalier, F., Cella, G., Chassande Mottin, E., Cleva, F., Cokelaer, T., Conforto, G., Corda, C., Coulon, J. P., Cuoco, E., Dattilo, V., Davier, M., De Rosa, R., Di Fiore, L., Di Virgilio, A., Dujardin, B., Eleuteri, A., Enard, D., Ferrante, I., Fidecaro, F., Fiori, I., Flaminio, R., Fournier, J. D., Frasca, S., Frasconi, F., Gammaitoni, L., Gennai, A., Giazotto, A., Giordano, G., Guidi, G., Heitmann, H., Hello, P., Heusse, P., Holloway, L., Kreckelbergh, S., La Penna, P., Loriette, V., Loupias, M., Losurdo, G., Mackowski, J. M., Majorana, E., Man, C. N., Marion, F., Martelli, F., Masserot, A., Massonnet, L., Mazzoni, M., Milano, L., Moreau, J., Moreau, F., Morgado, N., Mornet, F., Mours, B., Pacheco, J., Pai, A., Palomba, C., Paoletti, F., Passaquieti, R., Passuello, D., Perniola, B., Pinard, L., Poggiani, R., Punturo, M., Puppo, P., Qipiani, K., Ramonet, J., Rapagnani, P., Reita, V., Remillieux, A., Ricci, F., Ricciardi, I., Russo, G., Solimeno, S., Stanga, R., Toncelli, A., Tonelli, M., Tournefier, E., Travasso, F., Trinquet, H., Varvella, M., Verkindt, D., Vetrano, F., Veziant, O., Viceré, A., Vinet, J. Y., and Vocca, H.

Subjects
Data Analysis, Gravitational wave detectors and experiments
Published
2004

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