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1. Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population

Author: Padrela, Beatriz E, Lorenzini, Luigi, Collij, Lyduine E, García, David Vállez, Coomans, Emma, Ingala, Silvia, Tomassen, Jori, Deckers, Quinten, Shekari, Mahnaz, Geus, Eco JC de, van de Giessen, Elsmarieke, Kate, Mara ten, Visser, Pieter Jelle, Barkhof, Frederik, Petr, Jan, Braber, Anouk den, and Mutsaerts, Henk JMM
Published: 2023
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2. The genetic architecture of the human cerebral cortex

Author: Grasby, Katrina L, Jahanshad, Neda, Painter, Jodie N, Colodro-Conde, Lucía, Bralten, Janita, Hibar, Derrek P, Lind, Penelope A, Pizzagalli, Fabrizio, Ching, Christopher RK, McMahon, Mary Agnes B, Shatokhina, Natalia, Zsembik, Leo CP, Thomopoulos, Sophia I, Zhu, Alyssa H, Strike, Lachlan T, Agartz, Ingrid, Alhusaini, Saud, Almeida, Marcio AA, Alnæs, Dag, Amlien, Inge K, Andersson, Micael, Ard, Tyler, Armstrong, Nicola J, Ashley-Koch, Allison, Atkins, Joshua R, Bernard, Manon, Brouwer, Rachel M, Buimer, Elizabeth EL, Bülow, Robin, Bürger, Christian, Cannon, Dara M, Chakravarty, Mallar, Chen, Qiang, Cheung, Joshua W, Couvy-Duchesne, Baptiste, Dale, Anders M, Dalvie, Shareefa, de Araujo, Tânia K, de Zubicaray, Greig I, de Zwarte, Sonja MC, Braber, Anouk den, Doan, Nhat Trung, Dohm, Katharina, Ehrlich, Stefan, Engelbrecht, Hannah-Ruth, Erk, Susanne, Fan, Chun Chieh, Fedko, Iryna O, Foley, Sonya F, Ford, Judith M, Fukunaga, Masaki, Garrett, Melanie E, Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L, Green, Melissa J, Groenewold, Nynke A, Grotegerd, Dominik, Gurholt, Tiril P, Gutman, Boris A, Hansell, Narelle K, Harris, Mathew A, Harrison, Marc B, Haswell, Courtney C, Hauser, Michael, Herms, Stefan, Heslenfeld, Dirk J, Ho, New Fei, Hoehn, David, Hoffmann, Per, Holleran, Laurena, Hoogman, Martine, Hottenga, Jouke-Jan, Ikeda, Masashi, Janowitz, Deborah, Jansen, Iris E, Jia, Tianye, Jockwitz, Christiane, Kanai, Ryota, Karama, Sherif, Kasperaviciute, Dalia, Kaufmann, Tobias, Kelly, Sinead, Kikuchi, Masataka, Klein, Marieke, Knapp, Michael, Knodt, Annchen R, Krämer, Bernd, Lam, Max, Lancaster, Thomas M, Lee, Phil H, Lett, Tristram A, Lewis, Lindsay B, Lopes-Cendes, Iscia, Luciano, Michelle, Macciardi, Fabio, Marquand, Andre F, Mathias, Samuel R, Melzer, Tracy R, and Milaneschi, Yuri
Subjects: Biological Sciences, Genetics, Neurosciences, Mental Health, Brain Disorders, Stem Cell Research, 2.1 Biological and endogenous factors, Aetiology, Neurological, Attention Deficit Disorder with Hyperactivity, Brain Mapping, Cerebral Cortex, Cognition, Genetic Loci, Genetic Variation, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Organ Size, Parkinson Disease, Alzheimer’s Disease Neuroimaging Initiative, CHARGE Consortium, EPIGEN Consortium, IMAGEN Consortium, SYS Consortium, Parkinson’s Progression Markers Initiative, Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group, General Science & Technology
Abstract: The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
Published: 2020

3. Novel genetic loci underlying human intracranial volume identified through genome-wide association

Author: Adams, Hieab HH, Hibar, Derrek P, Chouraki, Vincent, Stein, Jason L, Nyquist, Paul A, Rentería, Miguel E, Trompet, Stella, Arias-Vasquez, Alejandro, Seshadri, Sudha, Desrivières, Sylvane, Beecham, Ashley H, Jahanshad, Neda, Wittfeld, Katharina, Van der Lee, Sven J, Abramovic, Lucija, Alhusaini, Saud, Amin, Najaf, Andersson, Micael, Arfanakis, Konstantinos, Aribisala, Benjamin S, Armstrong, Nicola J, Athanasiu, Lavinia, Axelsson, Tomas, Beiser, Alexa, Bernard, Manon, Bis, Joshua C, Blanken, Laura ME, Blanton, Susan H, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brickman, Adam M, Carmichael, Owen, Chakravarty, M Mallar, Chauhan, Ganesh, Chen, Qiang, Ching, Christopher RK, Cuellar-Partida, Gabriel, Braber, Anouk Den, Doan, Nhat Trung, Ehrlich, Stefan, Filippi, Irina, Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L, Gottesman, Rebecca F, Greven, Corina U, Grimm, Oliver, Griswold, Michael E, Guadalupe, Tulio, Hass, Johanna, Haukvik, Unn K, Hilal, Saima, Hofer, Edith, Hoehn, David, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kasperaviciute, Dalia, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Liao, Jiemin, Liewald, David CM, Lopez, Lorna M, Luciano, Michelle, Macare, Christine, Marquand, Andre, Matarin, Mar, Mather, Karen A, Mattheisen, Manuel, Mazoyer, Bernard, McKay, David R, McWhirter, Rebekah, Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Muetzel, Ryan L, Maniega, Susana Muñoz, Nho, Kwangsik, Nugent, Allison C, Loohuis, Loes M Olde, Oosterlaan, Jaap, Papmeyer, Martina, Pappa, Irene, Pirpamer, Lukas, Pudas, Sara, Pütz, Benno, Rajan, Kumar B, Ramasamy, Adaikalavan, Richards, Jennifer S, Risacher, Shannon L, Roiz-Santiañez, Roberto, Rommelse, Nanda, Rose, Emma J, Royle, Natalie A, Rundek, Tatjana, Sämann, Philipp G, and Satizabal, Claudia L
Subjects: Biological Psychology, Biomedical and Clinical Sciences, Neurosciences, Psychology, Clinical Research, Brain Disorders, Clinical Trials and Supportive Activities, Aging, Biotechnology, Genetics, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Neurological, Brain, Cognition, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Oncogene Protein v-akt, Parkinson Disease, Phenotype, Phosphatidylinositol 3-Kinases, Polymorphism, Single Nucleotide, White People, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract: Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits.
Published: 2016

4. ATN classification and clinical progression in subjective cognitive decline: The SCIENCe project

Author: Ebenau, Jarith L., Timmers, Tessa, Wesselman, Linda M.P., Verberk, Inge M.W., Verfaillie, Sander C.J., Slot, Rosalinde E.R., van Harten, Argonde C., Teunissen, Charlotte E., Barkhof, Frederik, van den Bosch, Karlijn A., van Leeuwenstijn, Mardou, Tomassen, Jori, Braber, Anouk den, Visser, Pieter Jelle, Prins, Niels D., Sikkes, Sietske A.M., Scheltens, Philip, van Berckel, Bart N.M., and van der Flier, Wiesje M.
Published: 2020
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5. sj-pdf-1-jcb-10.1177_0271678X231178993 - Supplemental material for Genetic, vascular, and amyloid components of cerebral blood flow in a preclinical population

Author: Padrela, Beatriz E, Lorenzini, Luigi, Collij, Lyduine E, García, David Vállez, Coomans, Emma, Ingala, Silvia, Tomassen, Jori, Deckers, Quinten, Shekari, Mahnaz, Geus, Eco JC de, van de Giessen, Elsmarieke, Kate, Mara ten, Visser, Pieter Jelle, Barkhof, Frederik, Petr, Jan, Braber, Anouk den, and Mutsaerts, Henk JMM
Subjects: 110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract: Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231178993 for Genetic, vascular, and amyloid components of cerebral blood flow in a preclinical population by Beatriz E Padrela, Luigi Lorenzini, Lyduine E Collij, David Vállez García, Emma Coomans, Silvia Ingala, Jori Tomassen, Quinten Deckers, Mahnaz Shekari, Eco JC de Geus, Elsmarieke van de Giessen, Mara ten Kate, Pieter Jelle Visser, Frederik Barkhof, Jan Petr, Anouk den Braber and Henk JMM Mutsaerts in Journal of Cerebral Blood Flow & Metabolism
Published: 2023
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6. Genetically identical twin-pair difference models support the amyloid cascade hypothesis.

Author: Coomans, Emma M, Tomassen, Jori, Ossenkoppele, Rik, Tijms, Betty M, Lorenzini, Luigi, Kate, Mara ten, Collij, Lyduine E, Heeman, Fiona, Rikken, Roos M, Landen, Sophie M van der, Hollander, Marijke E den, Golla, Sandeep S V, Yaqub, Maqsood, Windhorst, Albert D, Barkhof, Frederik, Scheltens, Philip, Geus, Eco J C de, Visser, Pieter Jelle, Berckel, Bart N M van, and Braber, Anouk den
Subjects: AMYLOID, GENERALIZED estimating equations, ALZHEIMER'S disease, EXPERIMENTAL design, TAU proteins, COUPLES
Abstract: The amyloid cascade hypothesis has strongly impacted the Alzheimer's disease research agenda and clinical trial designs over the past decades, but precisely how amyloid-β pathology initiates the aggregation of neocortical tau remains unclear. We cannot exclude the possibility of a shared upstream process driving both amyloid-β and tau in an independent manner instead of there being a causal relationship between amyloid-β and tau. Here, we tested the premise that if a causal relationship exists, then exposure should be associated with outcome both at the individual level as well as within identical twin-pairs, who are strongly matched on genetic, demographic and shared environmental background. Specifically, we tested associations between longitudinal amyloid-β PET and cross-sectional tau PET, neurodegeneration and cognitive decline using genetically identical twin-pair difference models, which provide the unique opportunity of ruling out genetic and shared environmental effects as potential confounders in an association. We included 78 cognitively unimpaired identical twins with [18F]flutemetamol (amyloid-β)-PET, [18F]flortaucipir (tau)-PET, MRI (hippocampal volume) and cognitive data (composite memory). Associations between each modality were tested at the individual level using generalized estimating equation models, and within identical twin-pairs using within-pair difference models. Mediation analyses were performed to test for directionality in the associations as suggested by the amyloid cascade hypothesis. At the individual level, we observed moderate-to-strong associations between amyloid-β, tau, neurodegeneration and cognition. The within-pair difference models replicated results observed at the individual level with comparably strong effect sizes. Within-pair differences in amyloid-β were strongly associated with within-pair differences in tau (β = 0.68, P < 0.001), and moderately associated with within-pair differences in hippocampal volume (β = −0.37, P = 0.03) and memory functioning (β = −0.57, P < 0.001). Within-pair differences in tau were moderately associated with within-pair differences in hippocampal volume (β = −0.53, P < 0.001) and strongly associated with within-pair differences in memory functioning (β = −0.68, P < 0.001). Mediation analyses showed that of the total twin-difference effect of amyloid-β on memory functioning, the proportion mediated through pathways including tau and hippocampal volume was 69.9%, which was largely attributable to the pathway leading from amyloid-β to tau to memory functioning (proportion mediated, 51.6%). Our results indicate that associations between amyloid-β, tau, neurodegeneration and cognition are unbiased by (genetic) confounding. Furthermore, effects of amyloid-β on neurodegeneration and cognitive decline were fully mediated by tau. These novel findings in this unique sample of identical twins are compatible with the amyloid cascade hypothesis and thereby provide important new knowledge for clinical trial designs. [ABSTRACT FROM AUTHOR]
Published: 2023
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7. Genetically identical twins show comparable tau PET load and spatial distribution.

Author: Coomans, Emma M, Tomassen, Jori, Ossenkoppele, Rik, Golla, Sandeep S V, Hollander, Marijke den, Collij, Lyduine E, Weltings, Emma, Landen, Sophie M van der, Wolters, Emma E, Windhorst, Albert D, Barkhof, Frederik, Geus, Eco J C de, Scheltens, Philip, Visser, Pieter Jelle, Berckel, Bart N M van, Braber, Anouk den, den Hollander, Marijke, van der Landen, Sophie M, de Geus, Eco J C, and van Berckel, Bart N M
Subjects: RESEARCH, ALZHEIMER'S disease, NERVE tissue proteins, RESEARCH methodology, TWINS, EVALUATION research, COMPARATIVE studies, APOLIPOPROTEINS, EMISSION-computed tomography
Abstract: Tau accumulation starts during the preclinical phase of Alzheimer's disease and is closely associated with cognitive decline. For preventive purposes, it is important to identify factors associated with tau accumulation and spread. Studying genetically identical twin-pairs may give insight into genetic and environmental contributions to tau pathology, as similarities in identical twin-pairs largely result from genetic factors, while differences in identical twin-pairs can largely be attributed to non-shared, environmental factors. This study aimed to examine similarities and dissimilarities in a cohort of genetically identical older twin-pairs in (i) tau load; and (ii) spatial distribution of tau, measured with 18F-flortaucipir PET. We selected 78 genetically identical twins (39 pairs; average age 73 ± 6 years), enriched for amyloid-β pathology and APOE ε4 carriership, who underwent dynamic 18F-flortaucipir PET. We extracted binding potentials (BPND) in entorhinal, temporal, widespread neocortical and global regions, and examined within-pair similarities in BPND using age and sex corrected intra-class correlations. Furthermore, we tested whether twin-pairs showed a more similar spatial 18F-flortaucipir distribution compared to non-twin pairs, and whether the participant's co-twin could be identified solely based on the spatial 18F-flortaucipir distribution. Last, we explored whether environmental (e.g. physical activity, obesity) factors could explain observed differences in twins of a pair in 18F-flortaucipir BPND. On visual inspection, Alzheimer's disease-like 18F-flortaucipir PET patterns were observed, and although we mainly identified similarities in twin-pairs, some pairs showed strong dissimilarities. 18F-flortaucipir BPND was correlated in twins in the entorhinal (r = 0.40; P = 0.01), neocortical (r = 0.59; P < 0.01) and global (r = 0.56; P < 0.01) regions, but not in the temporal region (r = 0.20; P = 0.10). The 18F-flortaucipir distribution pattern was significantly more similar between twins of the same pair [mean r = 0.27; standard deviation (SD) = 0.09] than between non-twin pairings of participants (mean r = 0.01; SD = 0.10) (P < 0.01), also after correcting for proxies of off-target binding. Based on the spatial 18F-flortaucipir distribution, we could identify with an accuracy of 86% which twins belonged to the same pair. Finally, within-pair differences in 18F-flortaucipir BPND were associated with within-pair differences in depressive symptoms (0.37 < β < 0.56), physical activity (-0.41 < β < -0.42) and social activity (-0.32 < β < -0.36) (all P < 0.05). Overall, identical twin-pairs were comparable in tau load and spatial distribution, highlighting the important role of genetic factors in the accumulation and spreading of tau pathology. Considering also the presence of dissimilarities in tau pathology in identical twin-pairs, our results additionally support a role for (potentially modifiable) environmental factors in the onset of Alzheimer's disease pathological processes, which may be of interest for future prevention strategies. [ABSTRACT FROM AUTHOR]
Published: 2022
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8. Brain volume in male patients with recent onset schizophrenia with and without cannabis use disorders

Author: Koenders, Laura, Machielsen, Marise W.J., van der Meer, Floor J., van Gasselt, Angelique C.M., Meijer, Carin J., van den Brink, Wim, Koeter, Maarten W.J., Caan, Matthan W.A., Cousijn, Janna, Braber, Anouk den, van ‘t Ent, Dennis, Rive, Maaike M., Schene, Aart H., van de Giessen, Elsmarieke, Huyser, Chaim, de Kwaasteniet, Bart P., Veltman, Dick J., and de Haan, Lieuwe
Published: 2015
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9. White matter microstructure disruption in early stage amyloid pathology

Author: Collij, Lyduine E., primary, Ingala, Silvia, additional, Top, Herwin, additional, Wottschel, Viktor, additional, Stickney, Kristine E., additional, Tomassen, Jori, additional, Konijnenberg, Elles, additional, ten Kate, Mara, additional, Sudre, Carole, additional, Lopes Alves, Isadora, additional, Yaqub, Maqsood M., additional, Wink, Alle Meije, additional, Van ‘t Ent, Dennis, additional, Scheltens, Philip, additional, van Berckel, Bart N.M., additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, and Braber, Anouk Den, additional
Published: 2021
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10. Additional file 1 of Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study

Author: Kreeke, Jacoba A. Van De, Legdeur, Nienke, Badissi, Maryam, H. Ton Nguyen, Konijnenberg, Elles, Tomassen, Jori, Kate, Mara Ten, Braber, Anouk Den, Maier, Andrea B., H. Stevie Tan, Verbraak, Frank D., and Visser, Pieter Jelle
Subjects: genetic structures, sense organs, eye diseases
Abstract: Additional file 1. Reasons for excluding participants, categorized per group. Note that participants were only excluded if bilateral problems were present, explaining why the total N may be lower than the subdivided numbers taken together (i.e. 1 eye of a participant may fall in 1 category, and the contralateral eye in another). CI = Cognitively Impaired, OCT = Optical Coherence Tomography, SIVA = Singapore I Vessel Assessment, AMD = Age-related Macular Degeneration, ERM = Epiretinal Membrane, PPA = Peripapillary Atrophy, CSC = Central Serous Chorioretinopathy.
Published: 2020
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11. Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

Author: Frangou, Sophia, primary, Modabbernia, Amirhossein, additional, Doucet, Gaelle E, additional, Papachristou, Efstathios, additional, Williams, Steven CR, additional, Agartz, Ingrid, additional, Aghajani, Moji, additional, Akudjedu, Theophilus N, additional, Albajes-Eizagirre, Anton, additional, Alnæs, Dag, additional, Alpert, Kathryn I, additional, Andersson, Micael, additional, Andreasen, Nancy, additional, Andreassen, Ole A, additional, Asherson, Philip, additional, Banaschewski, Tobias, additional, Bargallo, Nuria, additional, Baumeister, Sarah, additional, Baur-Streubel, Ramona, additional, Bertolino, Alessandro, additional, Bonvino, Aurora, additional, Boomsma, Dorret I, additional, Borgwardt, Stefan, additional, Bourque, Josiane, additional, Brandeis, Daniel, additional, Breier, Alan, additional, Brodaty, Henry, additional, Brouwer, Rachel M, additional, Buitelaar, Jan K, additional, Busatto, Geraldo F, additional, Buckner, Randy L, additional, Calhoun, Vincent, additional, Canales-Rodríguez, Erick J, additional, Cannon, Dara M, additional, Caseras, Xavier, additional, Castellanos, Francisco X, additional, Cervenka, Simon, additional, Chaim-Avancini, Tiffany M, additional, Ching, Christopher RK, additional, Clark, Vincent P, additional, Conrod, Patricia, additional, Conzelmann, Annette, additional, Crespo-Facorro, Benedicto, additional, Crivello, Fabrice, additional, Crone, Eveline AM, additional, Dale, Anders M, additional, Davey, Cristopher, additional, de Geus, Eco JC, additional, de Haan, Lieuwe, additional, de Zubicaray, Greig I, additional, Braber, Anouk den, additional, Dickie, Erin W, additional, Di Giorgio, Annabella, additional, Doan, Nhat Trung, additional, Dørum, Erlend S, additional, Ehrlich, Stefan, additional, Erk, Susanne, additional, Espeseth, Thomas, additional, Fatouros-Bergman, Helena, additional, Fisher, Simon E, additional, Fouche, Jean-Paul, additional, Franke, Barbara, additional, Frodl, Thomas, additional, Fuentes-Claramonte, Paola, additional, Glahn, David C, additional, Gotlib, Ian H, additional, Grabe, Hans-Jörgen, additional, Grimm, Oliver, additional, Groenewold, Nynke A, additional, Grotegerd, Dominik, additional, Gruber, Oliver, additional, Gruner, Patricia, additional, Gur, Rachel E, additional, Gur, Ruben C, additional, Harrison, Ben J, additional, Hartman, Catharine A, additional, Hatton, Sean N, additional, Heinz, Andreas, additional, Heslenfeld, Dirk J, additional, Hibar, Derrek P, additional, Hickie, Ian B, additional, Ho, Beng-Choon, additional, Hoekstra, Pieter J, additional, Hohmann, Sarah, additional, Holmes, Avram J, additional, Hoogman, Martine, additional, Hosten, Norbert, additional, Howells, Fleur M, additional, Hulshoff Pol, Hilleke E, additional, Huyser, Chaim, additional, Jahanshad, Neda, additional, James, Anthony, additional, Jiang, Jiyang, additional, Jönsson, Erik G, additional, Joska, John A, additional, Kahn, Rene, additional, Kalnin, Andrew, additional, Kanai, Ryota, additional, Kang, Sim, additional, Klein, Marieke, additional, Klushnik, Tatyana P, additional, Koenders, Laura, additional, Koops, Sanne, additional, Krämer, Bernd, additional, Kuntsi, Jonna, additional, Lagopoulos, Jim, additional, Lázaro, Luisa, additional, Lebedeva, Irina, additional, Lee, Won Hee, additional, Lesch, Klaus-Peter, additional, Lochner, Christine, additional, Machielsen, Marise WJ, additional, Maingault, Sophie, additional, Martin, Nicholas G, additional, Martínez-Zalacaín, Ignacio, additional, Mataix-Cols, David, additional, Mazoyer, Bernard, additional, McDonald, Colm, additional, McDonald, Brenna C, additional, McIntosh, Andrew M, additional, McMahon, Katie L, additional, McPhilemy, Genevieve, additional, Menchón, José M, additional, Medland, Sarah E, additional, Meyer-Lindenberg, Andreas, additional, Naaijen, Jilly, additional, Najt, Pablo, additional, Nakao, Tomohiro, additional, Nordvik, Jan E, additional, Nyberg, Lars, additional, Oosterlaan, Jaap, additional, de la Foz, Víctor Ortiz-García, additional, Paloyelis, Yannis, additional, Pauli, Paul, additional, Pergola, Giulio, additional, Pomarol-Clotet, Edith, additional, Portella, Maria J, additional, Potkin, Steven G, additional, Radua, Joaquim, additional, Reif, Andreas, additional, Roffman, Joshua L, additional, Rosa, Pedro GP, additional, Sacchet, Matthew D, additional, Sachdev, Perminder S, additional, Salvador, Raymond, additional, Sánchez-Juan, Pascual, additional, Sarró, Salvador, additional, Satterthwaite, Theodore D, additional, Saykin, Andrew J, additional, Serpa, Mauricio H, additional, Schmaal, Lianne, additional, Schnell, Knut, additional, Schumann, Gunter, additional, Smoller, Jordan W, additional, Sommer, Iris, additional, Soriano-Mas, Carles, additional, Stein, Dan J, additional, Strike, Lachlan T, additional, Swagerman, Suzanne C, additional, Tamnes, Christian K, additional, Temmingh, Henk S, additional, Thomopoulos, Sophia I, additional, Tomyshev, Alexander S, additional, Tordesillas-Gutiérrez, Diana, additional, Trollor, Julian N, additional, Turner, Jessica A, additional, Uhlmann, Anne, additional, van den Heuvel, Odille A, additional, van den Meer, Dennis, additional, van der Wee, Nic JA, additional, van Haren, Neeltje EM, additional, van ’t Ent, Dennis, additional, van Erp, Theo GM, additional, Veer, Ilya M, additional, Veltman, Dick J, additional, Völzke, Henry, additional, Walter, Henrik, additional, Walton, Esther, additional, Wang, Lei, additional, Wang, Yang, additional, Wassink, Thomas H, additional, Weber, Bernd, additional, Wen, Wei, additional, West, John D, additional, Westlye, Lars T, additional, Whalley, Heather, additional, Wierenga, Lara M, additional, Wittfeld, Katharina, additional, Wolf, Daniel H, additional, Wright, Margaret J, additional, Yang, Kun, additional, Yoncheva, Yulyia, additional, Zanetti, Marcus V, additional, Ziegler, Georg C, additional, Thompson, Paul M, additional, and Dima, Danai, additional
Published: 2020
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12. Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study

Author: de Kreeke, Jacoba Alida van, primary, Legdeur, Nienke, additional, Badissi, Maryam, additional, Nguyen, H. Ton, additional, Konijnenberg, Elles, additional, Tomassen, Jori, additional, Kate, Mara ten, additional, Braber, Anouk den, additional, Maier, Andrea B., additional, Tan, H. Stevie, additional, Verbraak, Frank D., additional, and Visser, Pieter Jelle, additional
Published: 2020
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13. Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

Author: Hofer, Edith, Roshchupkin, Gennady V., Adams, Hieab H. H., Knol, Maria J., Lin, Honghuang, Li, Shuo, Zare, Habil, Ahmad, Shahzad, Armstrong, Nicola J., Satizabal, Claudia L., Bernard, Manon, Bis, Joshua C., Gillespie, Nathan A., Luciano, Michelle, Mishra, Aniket, Scholz, Markus, Teumer, Alexander, Xia, Rui, Jian, Xueqiu, Mosley, Thomas H., Saba, Yasaman, Pirpamer, Lukas, Seiler, Stephan, Becker, James T., Carmichael, Owen, Rotter, Jerome I., Psaty, Bruce M., Lopez, Oscar L., Amin, Najaf, van der Lee, Sven J., Yang, Qiong, Himali, Jayandra J., Maillard, Pauline, Beiser, Alexa S., DeCarli, Charles, Karama, Sherif, Lewis, Lindsay, Harris, Mat, Bastin, Mark E., Deary, Ian J., Witte, A.Veronica, Beyer, Frauke, Loeffler, Markus, Mather, Karen A., Schofield, Peter R., Thalamuthu, Anbupalam, Kwok, John B., Wright, Margaret J., Ames, David, Trollor, Julian, Jiang, Jiyang, Brodaty, Henry, Wen, Wei, Vernooij, Meike W, Hofman, Albert, Uitterlinden, André G., Niessen, Wiro J., Wittfeld, Katharina, Bülow, Robin, Völker, Uwe, Pausova, Zdenka, Pike, G. Bruce, Maingault, Sophie, Crivello, Fabrice, Tzourio, Christophe, Amouye, Philippe, Mazoyer, Bernard, Neale, Michael C., Franz, Carol E., Lyons, Michael J., Panizzon, Matthew S., Andreassen, Ole A., Dale, Anders M., Logue, Mark, Grasby, Katrina L., Jahanshad, Neda, Painter, Jodie N., Colodro-Conde, Lucía, Bralten, Janita, Hibar, Derrek P., Lind, Penelope A., Pizzagalli, Fabrizio, Stein, Jason L., Thompson, Paul M., Medland, Sarah E., Ching Christopher, R.K., McMahon Mary Agnes, B., Shatokhina, Natalia, Zsembik, Leo C.P., Agartz, Ingrid, Alhusaini, Saud, Almeida, Marcio A.A., Alnæs, Dag, Amlien, Inge K., Andersson, Micael, Ard, Tyler, Ashley-Koch, Allison, Brouwer, Rachel M., Buimer, Elizabeth E.L., Bürger, Christian, Cannon, Dara M., Chakravarty, Mallar, Chen, Qiang, Cheung, Joshua W., Couvy-Duchesne, Baptiste, Dalvie, Shareefa, de Araujo, Tânia K., de Zubicaray, Greig I., de Zwarte, Sonja M.C., Braber, Anouk den, Doan, Nhat Trung, Dohm, Katharina, Ehrlich, Stefan, Engelbrecht, Hannah-Ruth, Erk, Susanne, Fan, Chun Chieh, Fedko, Iryna O., Foley, Sonya F., Ford, Judith M., Fukunaga, Masaki, Garrett, Melanie E., Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L., Groenewold, Nynke A., Grotegerd, Dominik, Gurholt, Tiril P., Gutman, Boris A., Hansell, Narelle K., Harris, Mathew A., Harrison, Marc B., Haswell, Courtney C., Hauser, Michael, Herms, Stefan, Heslenfeld, Dirk J., Ho, New Fei, Hoehn, David, Hoffmann, Per, Holleran, Laurena, Hoogman, Martine, Hottenga, Jouke-Jan, Ikeda, Masashi, Janowitz, Deborah, Jansen, Iris E., Jia, Tianye, Jockwitz, Christiane, Kanai, Ryota, Kasperaviciute, Dalia, Kaufmann, Tobias, Kelly, Sinead, Kikuchi, Masataka, Klein, Marieke, Knapp, Michael, Knodt, Annchen R., Krämer, Bernd, Lam, Max, Lancaster, Thomas M., Lee, Phil H., Lett, Tristram A., Lewis, Lindsay B., Lopes-Cendes, Iscia, Macciardi, Fabio, Marquand, Andre F., Mathias, Samuel R., Melzer, Tracy R., Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Moreira, Jose C.V., Mühleisen, Thomas W., Müller-Myhsok, Bertram, Najt, Pablo, Nakahara, Soichiro, Nho, Kwangsik, Olde Loohuis, Loes M., Orfanos, Dimitri Papadopoulos, Pearson, John F., Pitcher, Toni L., Pütz, Benno, Ragothaman, Anjanibhargavi, Rashid, Faisal M., Ronny, Redlich, Reinbold, Céline S., Repple, Jonathan, Richard, Geneviève, Riedel, Brandalyn C., Risacher, Shannon L., Rocha, Cristiane S., Mota, Nina Roth, Salminen, Lauren, Saremi, Arvin, Saykin, Andrew J., Schlag, Fenja, Schmaal, Lianne, Secolin, Rodrigo, Shapland, Chin Yang, Shen, Li, Shin, Jean, Shumskaya, Elena, Sønderby, Ida E., Sprooten, Emma, Strike, Lachlan T., Tansey, Katherine E., Thomopoulos, Sophia I., Tordesillas-Gutiérrez, Diana, Turner, Jessica A., Uhlmann, Anne, Vallerga, Costanza Ludovica, der Meer, Dennis van, van Donkelaar, Marjolein M.J., Eijk, Liza van, van Erp, Theo G.M., van Haren, Neeltje E.M., Rooij, Daan van, van Tol, Marie-José, Veldink, Jan H., Verhoef, Ellen, Walton, Esther, Wang, Mingyuan, Wang, Yunpeng, Wardlaw, Joanna M., Westlye, Lars T., Whelan, Christopher D., Witt, Stephanie H., Wolf, Christiane, Wolfers, Thomas, Yasuda, Clarissa L., Zaremba, Dario, Zhang, Zuo, Zhu, Alyssa H., Zwiers, Marcel P., Artiges, Eric, Assareh, Amelia A., Ayesa-Arriola, Rosa, Belger, Aysenil, Brandt, Christine L., Brown, Gregory G., Cichon, Sven, Curran, Joanne E., Davies, Gareth E., Degenhardt, Franziska, Dietsche, Bruno, Djurovic, Srdjan, Doherty, Colin P., Espiritu, Ryan, Garijo, Daniel, Gil, Yolanda, Gowland, Penny A., Green, Robert C., Häusler, Alexander N., Heindel, Walter, Ho, Beng-Choon, Hoffmann, Wolfgang U., Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Jack Jr., Clifford R., Jang, MiHyun, Jansen, Andreas, Kolskår, Knut, Koops, Sanne, Krug, Axel, Lim, Kelvin O., Luykx, Jurjen J., Mathalon, Daniel H., Mattay, Venkata S., Matthews, Sarah, Van Son, Jaqueline Mayoral, McEwen, Sarah C., Melle, Ingrid, Morris, Derek W., Mueller, Bryon A., Nauck, Matthias, Nordvik, Jan E., Nöthen, Markus M., O’Leary, Daniel S., Opel, Nils, Paillère Martinot, Marie-Laure, Preda, Adrian, Quinlan, Erin B., Ratnakar, Varun, Reppermund, Simone, Steen, Vidar M., Torres, Fábio R., Veltman, Dick J., Voyvodic, James T., Whelan, Robert, White, Tonya, Yamamori, Hidenaga, Alvim, Marina K.M., Anderson, Tim J., Arias-Vasquez, Alejandro, Baune, Bernhard T., Blangero, John, Boomsma, Dorret I., Brunner, Han G., Buckner, Randy L., Buitelaar, Jan K., Bustillo, Juan R., Cahn, Wiepke, Calhoun, Vince, Caseras, Xavier, Caspers, Svenja, Cavalleri, Gianpiero L., Cendes, Fernando, Corvin, Aiden, Crespo-Facorro, Benedicto, Dalrymple-Alford, John C., Dannlowski, Udo, de Geus, Eco J.C., Delanty, Norman, Depondt, Chantal, Desrivières, Sylvane, Donohoe, Gary, Espeseth, Thomas, Fernández, Guillén, Fisher, Simon E., Flor, Herta, Forstner, Andreas J., Francks, Clyde, Franke, Barbara, Glahn, David C., Gollub, Randy L., Grabe, Hans J., Gruber, Oliver, Håberg, Asta K., Hariri, Ahmad R., Hartman, Catharina A., Hashimoto, Ryota, Heinz, Andreas, Hillegers, Manon H.J., Hoekstra, Pieter J., Holmes, Avram J., Hong, L. Elliot, Hopkins, William D., Hulshoff Pol, Hilleke E., Jernigan, Terry L., Jönsson, Erik G., Kahn, René S., Kennedy, Martin A., Kircher, Tilo T.J., Kochunov, Peter, Kwok, John B.J., Hellard, Stephanie Le, Martin, Nicholas G., Martinot, Jean - Luc, McDonald, Colm, McMahon, Katie L., Meyer-Lindenberg, Andreas, Morey, Rajendra A., Nyberg, Lars, Oosterlaan, Jaap, Ophoff, Roel A., Paus, Tomáš, Penninx, Brenda W.J.H., Polderman, Tinca J.C., Posthuma, Danielle, Rietschel, Marcella, Roffman, Joshua L., Rowland, Laura M., Sachdev, Perminder S., Sämann, Philipp G., Schumann, Gunter, Sim, Kang, Sisodiya, Sanjay M., Smoller, Jordan W., Sommer, Iris E., Pourcain, Beate St, Stein, Dan J., Toga, Arthur W., Trollor, Julian N., Van der Wee, Nic J.A., Ent, Dennis van’t, Völzke, Henry, Walter, Henrik, Weber, Bernd, Weinberger, Daniel R., Zhou, Juan, Kremen, William S., Villringer, Arno, Duijn, Cornelia M. van, Jörgen Grabe, Hans, Longstreth Jr, William T., Fornage, Myriam, Paus, Tomas, Debette, Stephanie, Ikram, M. Arfan, Schmidt, Helena, Schmidt, Reinhold, Seshadri, Sudha, and ENIGMA consortium
Subjects: 0303 health sciences, biology, Genetic heterogeneity, Cognition, Hindbrain, Disease, Heritability, Biobank, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Evolutionary biology, Cortex (anatomy), biology.protein, medicine, Sonic hedgehog, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract: Cortical thickness, surface area and volumes (MRI cortical measures) vary with age and cognitive function, and in neurological and psychiatric diseases. We examined heritability, genetic correlations and genome-wide associations of cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprised 22,822 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the United Kingdom Biobank. Significant associations were replicated in the Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) consortium, and their biological implications explored using bioinformatic annotation and pathway analyses. We identified genetic heterogeneity between cortical measures and brain regions, and 161 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There was enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
Published: 2018

14. Planar cell polarity pathway and development of the human visual cortex

Author: Shin, Jean, Ma, Shaojie, Hofer, Edith, Patel, Yash, Roshchupkin, Gennady V., Sousa, André M., Jian, Xueqiu, Gottesman, Rebecca, Mosley, Thomas H., Fornage, Myriam, Saba, Yasaman, Pirpamer, Lukas, Schmidt, Reinhold, Schmidt, Helena, Carrion-Castillo, Amaia, Crivello, Fabrice, Mazoyer, Bernard, Bis, Joshua C., Li, Shuo, Yang, Qiong, Luciano, Michelle, Karama, Sherif, Lewis, Lindsay, Bastin, Mark, Harris, Mathew A., Wardlaw, Joanna M., Deary, Ian E., Scholz, Markus, Loeffler, Markus, Witte, Veronica, Beyer, Frauke, Villringer, Arno, Armstrong, Nicola J, Mather, Karen A., Ames, David, Jiang, Jiyang, Kwok, John B, Schofield, Peter R., Thalamuthu, Anbupalam, Trollor, Julian N., Wright, Margaret J., Brodaty, Henry, Wen, Wei, Sachdev, Perminder S., Terzikhan, Natalie, Evans, Tavia E., Adams, Hieab H.H.H., Ikram, M. Arfan, Frenzel, Stefan, van der Auwera-Palitschka, Sandra, Wittfeld, Katharina, Bülow, Robin, Grabe, Hans Jörgen, Tzourio, Christophe, Mishra, Aniket, Maingault, Sophie, Debette, Stephanie, Gillespie, Nathan A., Franz, Carol E., Kremen, William S., Ding, Linda, Jahanshad, Neda, Sestan, Nenad, Pausova, Zdenka, Seshadri, Sudha, Paus, Tomas, Grasby, Katrina L., Painter, Jodie N., Colodro-Conde, Lucía, Bralten, Janita, Hibar, Derrek P., Lind, Penelope A., Pizzagalli, Fabrizio, Ching, Christopher R.K., McMahon, Mary Agnes B., Shatokhina, Natalia, Zsembik, Leo, Agartz, Ingrid, Alhusaini, Saud, Almeida, Marcio A.A., Alnæs, Dag, Amlien, Inge K., Andersson, Micael, Ard, Tyler, Armstrong, Nicola J., Ashley-Koch, Allison, Bernard, Manon, Brouwer, Rachel M., Buimer, Elizabeth E.L., Bürger, Christian, Cannon, Dara M., Chakravarty, Mallasr, Chen, Qiang, Cheung, Joshua W., Couvy-Duchesne, Baptiste, Dale, Anders M., Dalvie, Shareefa, de Araujo, Tânia K., de Zubicaray, Greig I., de Zwarte, Sonja M.C., Braber, Anouk den, Doan, Nhat Trung, Dohm, Katharina, Ehrlich, Stefan, Engelbrecht, Hannah-Ruth, Erk, Susanne, Fan, Chun Chieh, Fedko, Iryna O., Foley, Sonya F., Ford, Judith M., Fukunaga, Masaki, Garrett, Melanie E., Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L., Groenewold, Nynke A., Grotegerd, Dominik, Gurholt, Tiril P., Gutman, Boris A., Hansell, Narelle K., Harrison, Marc B., Haswell, Courtney C., Hauser, Michael, Heslenfeld, Dirk J., Hoehn, David, Holleran, Laurena, Hoogman, Martine, Hottenga, Jouke-Jan, Ikeda, Masashi, Janowitz, Deborah, Jansen, Iris E., Jia, Tianye, Jockwitz, Christiane, Kanai, Ryota, Kasperaviciute, Dalia, Kaufmann, Tobias, Kelly, Sinead, Kikuchi, Masataka, Klein, Marieke, Knapp, Michael, Knodt, Annchen R., Krämer, Bernd, Lancaster, Thomas M., Lee, Phil H., Lett, Tristram A., Lewis, Lindsay B., Lopes-Cendes, Iscia, Macciardi, Fabio, Marquand, Andre F., Mathias, Samuel R., Melzer, Tracy R., Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Moreira, Jose C.V., Mühleisen, Thomas W., Müller-Myhsok, Bertram, Najt, Pablo, Nakahara, Soichiro, Nho, Kwangsik, Olde Loohuis, Loes M., Orfanos, Dimitri Papadopoulos, Pearson, John F., Pitcher, Toni L., Pütz, Benno, Ragothaman, Anjanibhargavi, Rashid, Faisal M., Redlich, Ronny, Reinbold, Céline S., Repple, Jonathan, Richard, Geneviève, Riedel, Brandalyn C., Risacher, Shannon L., Rocha, Cristiane S., Mota, Nina Roth, Salminen, Lauren, Saremi, Arvin, Saykin, Andrew J., Schlag, Fenja, Schmaal, Lianne, Secolin, Rodrigo, Shapland, Chin Yang, Shen, Li, Shumskaya, Elena, Sønderby, Ida E., Sprooten, Emma, Strike, Lachlan T., Tansey, Katherine E., Teumer, Alexander, Thomopoulos, Sophia I., Tordesillas-Gutiérrez, Diana, Turner, Jessica A., Uhlmann, Anne, Vallerga, Costanza Ludovica, van der Meer, Dennis, van Donkelaar, Marjolein M.J., van Eijk, Liza, van Erp, Theo G.M., van Haren, Neeltje E.M., van Rooij, Daan, van Tol, Marie-José, Veldink, Jan H., Verhoef, Ellen, Walton, Esther, Wang, Yunpeng, Westlye, Lars T., Whelan, Christopher D., Witt, Stephanie H., Wolf, Christiane, Wolfers, Thomas, Yasuda, Clarissa L., Zaremba, Dario, Zhang, Zuo, Zhu, Alyssa H., Zwiers, Marcel P., Artiges, Eric, Assareh, Amelia A., Ayesa-Arriola, Rosa, Belger, Aysenil, Brandt, Christine L., Brown, Gregory G., Cichon, Sven, Curran, Joanne E., Davies, Gareth E., Degenhardt, Franziska, Dietsche, Bruno, Djurovic, Srdjan, Doherty, Colin P., Espiritu, Ryan, Garijo, Daniel, Gil, Yolanda, Gowland, Penny A., Green, Robert C., Häusler, Alexander N., Heindel, Walter, Ho, Beng-Choon, Hoffmann, Wolfgang U., Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Jack Jr., Clifford R., Jang, MiHyun, Jansen, Andreas, Kolskår, Knut, Koops, Sanne, Krug, Axel, Lim, Kelvin O., Luykx, Jurjen J., Mathalon, Daniel H., Mattay, Venkata S., Matthews, Sarah, Van Son, Jaqueline Mayoral, McEwen, Sarah C., Melle, Ingrid, Morris, Derek W., Mueller, Bryon A., Nauck, Matthias, Nordvik, Jan E., Nöthen, Markus M., O’Leary, Daniel S., Opel, Nils, Martinot, Marie - Laure Paillère, Pike, G. Bruce, Preda, Adrian, Quinlan, Erin B., Ratnakar, Varun, Reppermund, Simone, Steen, Vidar M., Torres, Fábio R., Veltman, Dick J., Voyvodic, James T., Whelan, Robert, White, Tonya, Yamamori, Hidenaga, Alvim, Marina K.M., Anderson, Tim J., Andreassen, Ole A., Arias-Vasquez, Alejandro, Bastin, Mark E., Baune, Bernhard T., Blangero, John, Boomsma, Dorret I., Brunner, Han G., Buckner, Randy L., Buitelaar, Jan K., Bustillo, Juan R., Cahn, Wiepke, Calhoun, Vince, Caseras, Xavier, Caspers, Svenja, Cavalleri, Gianpiero L., Cendes, Fernando, Corvin, Aiden, Crespo-Facorro, Benedicto, Dalrymple-Alford, John C., Dannlowski, Udo, de Geus, Eco J.C., Deary, Ian J., Delanty, Norman, Depondt, Chantal, Desrivières, Sylvane, Donohoe, Gary, Espeseth, Thomas, Fernández, Guillén, Fisher, Simon E., Flor, Herta, Forstner, Andreas J., Francks, Clyde, Franke, Barbara, Glahn, David C., Gollub, Randy L., Grabe, Hans J., Gruber, Oliver, Håberg, Asta K., Hariri, Ahmad R., Hartman, Catharina A., Hashimoto, Ryota, Heinz, Andreas, Hillegers, Manon H.J., Hoekstra, Pieter J., Holmes, Avram J., Hong, L. Elliot, Hopkins, William D., Hulshoff Pol, Hilleke E., Jernigan, Terry L., Jönsson, Erik G., Kahn, René S., Kennedy, Martin A., Kircher, Tilo T.J., Kochunov, Peter, Kwok, John B.J., Le Hellard, Stephanie, Martin, Nicholas G., Martinot, Jean - Luc, McDonald, Colm, McMahon, Katie L., Meyer-Lindenberg, Andreas, Morey, Rajendra A., Nyberg, Lars, Oosterlaan, Jaap, Ophoff, Roel A., Penninx, Brenda W.J.H., Polderman, Tinca J.C., Posthuma, Danielle, Rietschel, Marcella, Roffman, Joshua L., Rowland, Laura M., Sämann, Philipp G., Schumann, Gunter, Sim, Kang, Sisodiya, Sanjay M., Smoller, Jordan W., Sommer, Iris E., St Pourcain, Beate, Stein, Dan J., Toga, Arthur W., Van der Wee, Nic J.A., van’t Ent, Dennis, Völzke, Henry, Walter, Henrik, Weber, Bernd, Weinberger, Daniel R., Zhou, Juan, Stein, Jason L., Thompson, Paul M., Medland, Sarah E., ENIGMA Consortium, and neuroCHARGE Working Group
Subjects: 0303 health sciences, DAAM1, Locus (genetics), Single-nucleotide polymorphism, Biology, Lateral geniculate nucleus, Phenotype, Chromosome 17 (human), 03 medical and health sciences, 0302 clinical medicine, Visual cortex, medicine.anatomical_structure, Cerebral cortex, medicine, Neuroscience, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract: The radial unit hypothesis provides a framework for global (proliferation) and regional (distribution) expansion of the primate cerebral cortex. Using principal component analysis (PCA), we have identified cortical regions with shared variance in their surface area and cortical thickness, respectively, segmented from magnetic resonance images obtained in 23,800 participants. We then carried out meta-analyses of genome-wide association studies of the first two principal components for each phenotype. For surface area (but not cortical thickness), we have detected strong associations between each of the components and single nucleotide polymorphisms in a number of gene loci. The first (global) component was associated mainly with loci on chromosome 17 (9.5e-32 ≤ p ≤ 2.8e-10), including those detected previously as linked with intracranial volume and/or general cognitive function. The second (regional) component captured shared variation in the surface area of the primary and adjacent secondary visual cortices and showed a robust association with polymorphisms in a locus on chromosome 14 containing Disheveled Associated Activator of Morphogenesis 1 (DAAM1; p=2.4e-34). DAAM1 is a key component in the planar-cell-polarity signaling pathway. In follow-up studies, we have focused on the latter finding and established that: (1) DAAM1 is highly expressed between 12th and 22nd post-conception weeks in the human cerebral cortex; (2) genes co-expressed with DAAM1 in the primary visual cortex are enriched in mitochondria-related pathways; and (3) volume of the lateral geniculate nucleus, which projects to regions of the visual cortex staining for cytochrome oxidase (a mitochondrial enzyme), correlates with the surface area of the visual cortex in major-allele homozygotes but not in carriers of the minor allele. Altogether, we speculate that, in concert with thalamocortical input to cortical subplate, DAAM1 enables migration of neurons to cytochrome-oxidase rich regions of the visual cortex, and, in turn, facilitates regional expansion of this set of cortical regions during development.
Published: 2018
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15. ASSESSMENT OF EARLY AMYLOID PATHOLOGY USING [18F]FLUTEMETAMOL POSITRON EMISSION TOMOGRAPHY: COMPARING VISUAL READ, SEMI-QUANTITATIVE AND QUANTITATIVE METHODS

Author: Collij, Lyduine, Konijnenberg, Elles, Reimand, Juhan, Kate, Mara ten, Braber, Anouk den, Alves, Isadora Lopes, Zwan, Marissa D., Yaqub, Maqsood M., van Assema, Daniëlle, Wink, Alle Meije, Lammertsma, Adriaan A., Scheltens, Philip, Visser, Pieter Jelle, Barkhof, Frederik, van Berckel, Bart N.M., Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Neurology, Amsterdam Neuroscience - Neurodegeneration, CCA - Imaging and biomarkers, Internal medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Neuroinfection & -inflammation, and CCA - Cancer biology and immunology
Published: 2018

16. EXTENSION AND VALIDATION OF AN AMYLOID STAGING MODEL: ASSOCIATIONS WITH CLINICAL MEASURES

Author: Collij, Lyduine, Heeman, Fiona, Konijnenberg, Elles, Braber, Anouk den, Yaqub, Maqsood M., Visser, Pieter Jelle, Wink, Alle Meije, Scheltens, Philip, Boellaard, Ronald, van Berckel, Bart N.M., Schmidt, Mark E., Barkhof, Frederik, Alves, Isadora Lopes, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Neurology, CCA - Imaging and biomarkers, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Neuroinfection & -inflammation, CCA - Cancer biology and immunology, and ACS - Heart failure & arrhythmias
Published: 2018

17. Additional file 1: of The EMIF-AD PreclinAD study: study design and baseline cohort overview

Author: Konijnenberg, Elles, Carter, Stephen, Kate, Mara Ten, Braber, Anouk Den, Tomassen, Jori, Chinenye Amadi, Wesselman, Linda, Hoang-Ton Nguyen, Kreeke, Jacoba Van De, Yaqub, Maqsood, Demuru, Matteo, Mulder, Sandra, Hillebrand, Arjan, Bouwman, Femke, Teunissen, Charlotte, SernĂŠ, Erik, Moll, Annette, Verbraak, Frank, Hinz, Rainer, Pendleton, Neil, Lammertsma, Adriaan, Berckel, Bart Van, Barkhof, Frederik, Dorret Boomsma, Scheltens, Philip, Herholz, Karl, and Visser, Pieter
Abstract: Table S1. Inclusion and exclusion criteria. (DOCX 36Â kb)
Published: 2018
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18. Additional file 3: of The EMIF-AD PreclinAD study: study design and baseline cohort overview

Author: Konijnenberg, Elles, Carter, Stephen, Kate, Mara Ten, Braber, Anouk Den, Tomassen, Jori, Chinenye Amadi, Wesselman, Linda, Hoang-Ton Nguyen, Kreeke, Jacoba Van De, Yaqub, Maqsood, Demuru, Matteo, Mulder, Sandra, Hillebrand, Arjan, Bouwman, Femke, Teunissen, Charlotte, SernĂŠ, Erik, Moll, Annette, Verbraak, Frank, Hinz, Rainer, Pendleton, Neil, Lammertsma, Adriaan, Berckel, Bart Van, Barkhof, Frederik, Dorret Boomsma, Scheltens, Philip, Herholz, Karl, and Visser, Pieter
Abstract: Table S3. Questionnaires baseline. (DOCX 37Â kb)
Published: 2018
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19. Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study

Author: de Kreeke, Jacoba Alida van, primary, Legdeur, Nienke, additional, Badissi, Maryam, additional, Nguyen, H. Ton, additional, Konijnenberg, Elles, additional, Tomassen, Jori, additional, Kate, Mara ten, additional, Braber, Anouk den, additional, Maier, Andrea B., additional, Tan, H. Stevie, additional, Verbraak, Frank D., additional, and Visser, Pieter Jelle, additional
Published: 2019
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20. Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Author: Jia, Tianye, primary, Chu, Congying, additional, Liu, Yun, additional, Dongen, Jenny van, additional, Armstrong, Nicola J, additional, Bastin, Mark E., additional, Carrillo-Roa, Tania, additional, Braber, Anouk den, additional, Harris, Mathew, additional, Jansen, Rick, additional, Liu, Jingyu, additional, Luciano, Michelle, additional, Ori, Anil P.S., additional, Santiañez, Roberto Roiz, additional, Ruggeri, Barbara, additional, Sarkisyan, Daniil, additional, Shin, Jean, additional, Sungeun, Kim, additional, Gutiérrez, Diana Tordesillas, additional, Ent, Dennis van’t, additional, Ames, David, additional, Artiges, Eric, additional, Bakalkin, Georgy, additional, Banaschewski, Tobias, additional, Bokde, Arun L.W., additional, Brodaty, Henry, additional, Bromberg, Uli, additional, Brouwer, Rachel, additional, Büchel, Christian, additional, Quinlan, Erin Burke, additional, Cahn, Wiepke, additional, de Zubicaray, Greig I., additional, Ekström, Tomas J., additional, Flor, Herta, additional, Fröhner, Juliane H., additional, Frouin, Vincent, additional, Garavan, Hugh, additional, Gowland, Penny, additional, Heinz, Andreas, additional, Ittermann, Bernd, additional, Jahanshad, Neda, additional, Jiang, Jiyang, additional, Kwok, John B., additional, Martin, Nicholas G., additional, Martinot, Jean-Luc, additional, Mather, Karen A., additional, McMahon, Katie L., additional, McRae, Allan F., additional, Nees, Frauke, additional, Orfanos, Dimitri Papadopoulos, additional, Paus, Tomáš, additional, Poustka, Luise, additional, Sämann, Philipp G., additional, Schofield, Peter R., additional, Smolka, Michael N., additional, Strike, Lachlan T., additional, Teeuw, Jalmar, additional, Thalamuthu, Anbupalam, additional, Trollor, Julian, additional, Walter, Henrik, additional, Wardlaw, Joanna M., additional, Wen, Wei, additional, Whelan, Robert, additional, Apostolova, Liana G., additional, Binder, Elisabeth B., additional, Boomsma, Dorret I., additional, Calhoun, Vince, additional, Crespo-Facorro, Benedicto, additional, Deary, Ian J., additional, Pol, Hilleke Hulshoff, additional, Ophoff, Roel A., additional, Pausova, Zdenka, additional, Sachdev, Perminder S., additional, Saykin, Andrew, additional, Wright, Margaret J., additional, Thompson, Paul M., additional, Schumann, Gunter, additional, and Desrivières, Sylvane, additional
Published: 2018
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21. Assessing Amyloid Pathology in Cognitively Normal Subjects Using 18F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods

Author: Collij, Lyduine E., primary, Konijnenberg, Elles, additional, Reimand, Juhan, additional, Kate, Mara ten, additional, Braber, Anouk den, additional, Alves, Isadora Lopes, additional, Zwan, Marissa, additional, Yaqub, Maqsood, additional, van Assema, Daniëlle M.E., additional, Wink, Alle Meije, additional, Lammertsma, Adriaan A., additional, Scheltens, Philip, additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, and van Berckel, Bart N.M., additional
Published: 2018
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22. Associations of Brain Pathology Cognitive and Physical Markers With Age in Cognitively Normal Individuals Aged 60-102 Years.

Author: Legdeur, Nienke, Tijms, Betty M, Konijnenberg, Elles, Braber, Anouk den, Kate, Mara ten, Sudre, Carole H, Tomassen, Jori, Badissi, Maryam, Yaqub, Maqsood, Barkhof, Frederik, Berckel, Bart N van, Boomsma, Dorret I, Scheltens, Philip, Holstege, Henne, Maier, Andrea B, Visser, Pieter Jelle, den Braber, Anouk, Ten Kate, Mara, and van Berckel, Bart N
Subjects: BRAIN diseases, GENERALIZED estimating equations, MUSCLE mass, SKELETAL muscle physiology, BRAIN, GRIP strength, RESEARCH, HIPPOCAMPUS (Brain), SKELETAL muscle, CROSS-sectional method, AGE distribution, RESEARCH methodology, EVALUATION research, MEDICAL cooperation, SEX distribution, COMPARATIVE studies, AGING, RESEARCH funding, EDUCATIONAL attainment, PEPTIDES
Abstract: The prevalence of brain pathologies increases with age and cognitive and physical functions worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology cognitive and physical functions with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60- to 70-year-old individuals. Prevalence of abnormal scores was estimated using Generalized Estimating Equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test, and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass, and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education, and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology cognitive and physical processes became abnormal with age. [ABSTRACT FROM AUTHOR]
Published: 2020
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23. Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

Author: Satizabal, Claudia L, primary, Adams, Hieab HH, additional, Hibar, Derrek P, additional, White, Charles C, additional, Stein, Jason L, additional, Scholz, Markus, additional, Sargurupremraj, Murali, additional, Jahanshad, Neda, additional, Smith, Albert V, additional, Bis, Joshua C, additional, Jian, Xueqiu, additional, Luciano, Michelle, additional, Hofer, Edith, additional, Teumer, Alexander, additional, van der Lee, Sven J, additional, Yang, Jingyun, additional, Yanek, Lisa R, additional, Lee, Tom V, additional, Li, Shuo, additional, Hu, Yanhui, additional, Koh, Jia Yu, additional, Eicher, John D, additional, Desrivières, Sylvane, additional, Arias-Vasquez, Alejandro, additional, Chauhan, Ganesh, additional, Athanasiu, Lavinia, additional, Renteria, Miguel E, additional, Kim, Sungeun, additional, Höhn, David, additional, Armstrong, Nicola J, additional, Chen, Qiang, additional, Holmes, Avram J, additional, Braber, Anouk den, additional, Kloszewska, Iwona, additional, Andersson, Micael, additional, Espeseth, Thomas, additional, Grimm, Oliver, additional, Abramovic, Lucija, additional, Alhusaini, Saud, additional, Milaneschi, Yuri, additional, Papmeyer, Martina, additional, Axelsson, Tomas, additional, Ehrlich, Stefan, additional, Roiz-Santiañez, Roberto, additional, Kraemer, Bernd, additional, Håberg, Asta K, additional, Jones, Hannah J, additional, Pike, G Bruce, additional, Stein, Dan J, additional, Stevens, Allison, additional, Bralten, Janita, additional, Vernooij, Meike W, additional, Harris, Tamara B, additional, Filippi, Irina, additional, Witte, A Veronica, additional, Guadalupe, Tulio, additional, Wittfeld, Katharina, additional, Mosley, Thomas H, additional, Becker, James T, additional, Doan, Nhat Trung, additional, Hagenaars, Saskia P, additional, Saba, Yasaman, additional, Cuellar-Partida, Gabriel, additional, Amin, Najaf, additional, Hilal, Saima, additional, Nho, Kwangsik, additional, Karbalai, Nazanin, additional, Arfanakis, Konstantinos, additional, Becker, Diane M, additional, Ames, David, additional, Goldman, Aaron L, additional, Lee, Phil H, additional, Boomsma, Dorret I, additional, Lovestone, Simon, additional, Giddaluru, Sudheer, additional, Le Hellard, Stephanie, additional, Mattheisen, Manuel, additional, Bohlken, Marc M, additional, Kasperaviciute, Dalia, additional, Schmaal, Lianne, additional, Lawrie, Stephen M, additional, Agartz, Ingrid, additional, Walton, Esther, additional, Tordesillas-Gutierrez, Diana, additional, Davies, Gareth E, additional, Shin, Jean, additional, Ipser, Jonathan C, additional, Vinke, Louis N, additional, Hoogman, Martine, additional, Knol, Maria J, additional, Jia, Tianye, additional, Burkhardt, Ralph, additional, Klein, Marieke, additional, Crivello, Fabrice, additional, Janowitz, Deborah, additional, Carmichael, Owen, additional, Haukvik, Unn K, additional, Aribisala, Benjamin S, additional, Schmidt, Helena, additional, Strike, Lachlan T, additional, Cheng, Ching-Yu, additional, Risacher, Shannon L, additional, Pütz, Benno, additional, Fleischman, Debra A, additional, Assareh, Amelia A, additional, Mattay, Venkata S, additional, Buckner, Randy L, additional, Mecocci, Patrizia, additional, Dale, Anders M, additional, Cichon, Sven, additional, Boks, Marco P, additional, Matarin, Mar, additional, Penninx, Brenda WJH, additional, Calhoun, Vince D, additional, Chakravarty, M Mallar, additional, Marquand, Andre, additional, Macare, Christine, additional, Masouleh, Shahrzad Kharabian, additional, Oosterlaan, Jaap, additional, Amouyel, Philippe, additional, Hegenscheid, Katrin, additional, Rotter, Jerome I, additional, Schork, Andrew J, additional, Liewald, David CM, additional, De Zubicaray, Greig I, additional, Wong, Tien Yin, additional, Shen, Li, additional, Sämann, Philipp G, additional, Brodaty, Henry, additional, Roffman, Joshua L, additional, De Geus, Eco JC, additional, Tsolaki, Magda, additional, Erk, Susanne, additional, Van Eijk, Kristel R, additional, Cavalleri, Gianpiero L, additional, Van der Wee, Nic JA, additional, McIntosh, Andrew M, additional, Gollub, Randy L, additional, Bulayeva, Kazima B, additional, Bernard, Manon, additional, Richards, Jennifer S, additional, Himali, Jayandra J, additional, Loeffler, Markus, additional, Rommelse, Nanda, additional, Hoffmann, Wolfgang, additional, Westlye, Lars T, additional, Valdés Hernández, Maria C, additional, Hansell, Narelle K, additional, Van Erp, Theo GM, additional, Wolf, Christiane, additional, Kwok, John BJ, additional, Vellas, Bruno, additional, Heinz, Andreas, additional, Loohuis, Loes M Olde, additional, Delanty, Norman, additional, Ho, Beng-Choon, additional, Ching, Christopher RK, additional, Shumskaya, Elena, additional, Hofman, Albert, additional, Van der Meer, Dennis, additional, Homuth, Georg, additional, Psaty, Bruce M, additional, Bastin, Mark, additional, Montgomery, Grant W, additional, Foroud, Tatiana M, additional, Reppermund, Simone, additional, Hottenga, Jouke-Jan, additional, Simmons, Andrew, additional, Meyer-Lindenberg, Andreas, additional, Cahn, Wiepke, additional, Whelan, Christopher D, additional, Van Donkelaar, Marjolein MJ, additional, Yang, Qiong, additional, Hosten, Norbert, additional, Green, Robert C, additional, Thalamuthu, Anbupalam, additional, Mohnke, Sebastian, additional, Pol, Hilleke E Hulshoff, additional, Lin, Honghuang, additional, Jack, Clifford R, additional, Schofield, Peter R, additional, Mühleisen, Thomas W, additional, Maillard, Pauline, additional, Potkin, Steven G, additional, Wen, Wei, additional, Fletcher, Evan, additional, Toga, Arthur W, additional, Gruber, Oliver, additional, Huentelman, Matthew, additional, Smith, George Davey, additional, Launer, Lenore J, additional, Nyberg, Lars, additional, Jönsson, Erik G, additional, Crespo-Facorro, Benedicto, additional, Koen, Nastassja, additional, Greve, Douglas, additional, Uitterlinden, André G, additional, Weinberger, Daniel R, additional, Steen, Vidar M, additional, Fedko, Iryna O, additional, Groenewold, Nynke A, additional, Niessen, Wiro J, additional, Toro, Roberto, additional, Tzourio, Christophe, additional, Longstreth, William T, additional, Ikram, M Kamran, additional, Smoller, Jordan W, additional, Van Tol, Marie-Jose, additional, Sussmann, Jessika E, additional, Paus, Tomas, additional, Lemaître, Hervé, additional, Mazoyer, Bernard, additional, Andreassen, Ole A, additional, Holsboer, Florian, additional, Veltman, Dick J, additional, Turner, Jessica A, additional, Pausova, Zdenka, additional, Schumann, Gunter, additional, Van Rooij, Daan, additional, Djurovic, Srdjan, additional, Deary, Ian J, additional, McMahon, Katie L, additional, Müller-Myhsok, Bertram, additional, Brouwer, Rachel M, additional, Soininen, Hilkka, additional, Pandolfo, Massimo, additional, Wassink, Thomas H, additional, Cheung, Joshua W, additional, Wolfers, Thomas, additional, Martinot, Jean-Luc, additional, Zwiers, Marcel P, additional, Nauck, Matthias, additional, Melle, Ingrid, additional, Martin, Nicholas G, additional, Kanai, Ryota, additional, Westman, Eric, additional, Kahn, René S, additional, Sisodiya, Sanjay M, additional, White, Tonya, additional, Saremi, Arvin, additional, van Bokhoven, Hans, additional, Brunner, Han G, additional, Völzke, Henry, additional, Wright, Margaret J, additional, Van 't Ent, Dennis, additional, Nöthen, Markus M, additional, Ophoff, Roel A, additional, Buitelaar, Jan K, additional, Fernández, Guillén, additional, Sachdev, Perminder S, additional, Rietschel, Marcella, additional, Van Haren, Neeltje EM, additional, Fisher, Simon E, additional, Beiser, Alexa S, additional, Francks, Clyde, additional, Saykin, Andrew J, additional, Mather, Karen A, additional, Romanczuk-Seiferth, Nina, additional, Hartman, Catharina A, additional, DeStefano, Anita L, additional, Heslenfeld, Dirk J, additional, Weiner, Michael W, additional, Walter, Henrik, additional, Hoekstra, Pieter J, additional, Nyquist, Paul A, additional, Franke, Barbara, additional, Bennett, David A, additional, Grabe, Hans J, additional, Johnson, Andrew D, additional, Chen, Christopher, additional, van Duijn, Cornelia M, additional, Lopez, Oscar L, additional, Fornage, Myriam, additional, Wardlaw, Joanna A, additional, Schmidt, Reinhold, additional, DeCarli, Charles, additional, De Jager, Philip L, additional, Villringer, Arno, additional, Debette, Stéphanie, additional, Gudnason, Vilmundur, additional, Medland, Sarah E, additional, Shulman, Joshua M, additional, Thompson, Paul M, additional, Seshadri, Sudha, additional, and Ikram, M Arfan, additional
Published: 2017
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24. TWIN CORRELATIONS FOR AMYLOID PATHOLOGY MEASURED WITH POSITRON EMISSION TOMOGRAPHY AND IN CEREBROSPINAL FLUID IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS

Author: Konijnenberg, Elles, primary, Braber, Anouk den, additional, Kate, Mara ten, additional, Adriaanse, Sofie, additional, Yaqub, Maqsood M., additional, van Uffelen, Kees WJ., additional, Teunissen, Charlotte E., additional, Vanderstichele, Hugo Marcel, additional, Boomsma, Dorret I., additional, van Berckel, Bart N.M., additional, Scheltens, Philip, additional, and Visser, Pieter Jelle, additional
Published: 2017
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25. Assessing Amyloid Pathology in Cognitively Normal Subjects Using 18F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods.

Author: Collij, Lyduine E., Konijnenberg, Elles, Reimand, Juhan, Kate, Mara ten, Braber, Anouk den, Alves, Isadora Lopes, Zwan, Marissa, Yaqub, Maqsood, van Assema, Daniëlle M. E., Wink, Alle Meije, Lammertsma, Adriaan A., Scheltens, Philip, Visser, Pieter Jelle, Barkhof, Frederik, and van Berckel, Bart N. M.
Published: 2019
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26. Novel genetic loci underlying human intracranial volume identified through genome-wide association

Author: Adams, Hieab H H, Hibar, Derrek P, Chouraki, Vincent, Stein, Jason L, Nyquist, Paul A, Rentería, Miguel E, Trompet, Stella, Arias-Vasquez, Alejandro, Seshadri, Sudha, Desrivières, Sylvane, Beecham, Ashley H, Jahanshad, Neda, Wittfeld, Katharina, Van der Lee, Sven J, Abramovic, Lucija, Alhusaini, Saud, Amin, Najaf, Andersson, Micael, Arfanakis, Konstantinos, Aribisala, Benjamin S, Armstrong, Nicola J, Athanasiu, Lavinia, Axelsson, Tomas, Beiser, Alexa, Bernard, Manon, Bis, Joshua C, Blanken, Laura M E, Blanton, Susan H, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brickman, Adam M, Carmichael, Owen, Chakravarty, M Mallar, Chauhan, Ganesh, Chen, Qiang, Ching, Christopher R K, Cuellar-Partida, Gabriel, Braber, Anouk Den, Doan, Nhat Trung, Ehrlich, Stefan, Filippi, Irina, Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L, Gottesman, Rebecca F, Greven, Corina U, Grimm, Oliver, Griswold, Michael E, Guadalupe, Tulio, Hass, Johanna, Haukvik, Unn K, Hilal, Saima, Hofer, Edith, Hoehn, David, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kasperaviciute, Dalia, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Liao, Jiemin, Liewald, David C M, Lopez, Lorna M, Luciano, Michelle, Macare, Christine, Marquand, Andre, Matarin, Mar, Mather, Karen A, Mattheisen, Manuel, Mazoyer, Bernard, McKay, David R, McWhirter, Rebekah, Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Muetzel, Ryan L, Maniega, Susana Muñoz, Nho, Kwangsik, Nugent, Allison C, Loohuis, Loes M Olde, Oosterlaan, Jaap, Papmeyer, Martina, Pappa, Irene, Pirpamer, Lukas, Pudas, Sara, Pütz, Benno, Rajan, Kumar B, Ramasamy, Adaikalavan, Richards, Jennifer S, Risacher, Shannon L, Roiz-Santiañez, Roberto, Rommelse, Nanda, Rose, Emma J, Royle, Natalie A, Rundek, Tatjana, Sämann, Philipp G, Satizabal, Claudia L, Schmaal, Lianne, Schork, Andrew J, Shen, Li, Shin, Jean, Shumskaya, Elena, Smith, Albert V, Sprooten, Emma, Strike, Lachlan T, Teumer, Alexander, Thomson, Russell, Tordesillas-Gutierrez, Diana, Toro, Roberto, Trabzuni, Daniah, Vaidya, Dhananjay, Van der Grond, Jeroen, Van der Meer, Dennis, Van Donkelaar, Marjolein M J, Van Eijk, Kristel R, Van Erp, Theo G M, Van Rooij, Daan, Walton, Esther, Westlye, Lars T, Whelan, Christopher D, Windham, Beverly G, Winkler, Anderson M, Woldehawariat, Girma, Wolf, Christiane, Wolfers, Thomas, Xu, Bing, Yanek, Lisa R, Yang, Jingyun, Zijdenbos, Alex, Zwiers, Marcel P, Agartz, Ingrid, Aggarwal, Neelum T, Almasy, Laura, Ames, David, Amouyel, Philippe, Andreassen, Ole A, Arepalli, Sampath, Assareh, Amelia A, Barral, Sandra, Bastin, Mark E, Becker, Diane M, Becker, James T, Bennett, David A, Blangero, John, van Bokhoven, Hans, Boomsma, Dorret I, Brodaty, Henry, Brouwer, Rachel M, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Bulayeva, Kazima B, Cahn, Wiepke, Calhoun, Vince D, Cannon, Dara M, Cavalleri, Gianpiero L, Chen, Christopher, Cheng, Ching-Yu, Cichon, Sven, Cookson, Mark R, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Czisch, Michael, Dale, Anders M, Davies, Gareth E, De Geus, Eco J C, De Jager, Philip L, de Zubicaray, Greig I, Delanty, Norman, Depondt, Chantal, DeStefano, Anita L, Dillman, Allissa, Djurovic, Srdjan, Donohoe, Gary, Drevets, Wayne C, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Espeseth, Thomas, Evans, Denis A, Fedko, Iryna O, Fernández, Guillén, Ferrucci, Luigi, Fisher, Simon E, Fleischman, Debra A, Ford, Ian, Foroud, Tatiana M, Fox, Peter T, Francks, Clyde, Fukunaga, Masaki, Gibbs, J Raphael, Glahn, David C, Gollub, Randy L, Göring, Harald H H, Grabe, Hans J, Green, Robert C, Gruber, Oliver, Gudnason, Vilmundur, Guelfi, Sebastian, Hansell, Narelle K, Hardy, John, Hartman, Catharina A, Hashimoto, Ryota, Hegenscheid, Katrin, Heinz, Andreas, Le Hellard, Stephanie, Hernandez, Dena G, Heslenfeld, Dirk J, Ho, Beng-Choon, Hoekstra, Pieter J, Hoffmann, Wolfgang, Hofman, Albert, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Hottenga, Jouke-Jan, Pol, Hilleke E Hulshoff, Ikeda, Masashi, Ikram, M Kamran, Jack, Clifford R, Jenkinson, Mark, Johnson, Robert, Jönsson, Erik G, Jukema, J Wouter, Kahn, René S, Kanai, Ryota, Kloszewska, Iwona, Knopman, David S, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Lemaître, Hervé, Liu, Xinmin, Longo, Dan L, Longstreth, W T, Lopez, Oscar L, Lovestone, Simon, Martinez, Oliver, Martinot, Jean-Luc, Mattay, Venkata S, McDonald, Colm, McIntosh, Andrew M, McMahon, Katie L, McMahon, Francis J, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mohnke, Sebastian, Montgomery, Grant W, Morris, Derek W, Mosley, Thomas H, Mühleisen, Thomas W, Müller-Myhsok, Bertram, Nalls, Michael A, Nauck, Matthias, Nichols, Thomas E, Niessen, Wiro J, Nöthen, Markus M, Nyberg, Lars, Ohi, Kazutaka, Olvera, Rene L, Ophoff, Roel A, Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W J H, Pike, G Bruce, Potkin, Steven G, Psaty, Bruce M, Reppermund, Simone, Rietschel, Marcella, Roffman, Joshua L, Romanczuk-Seiferth, Nina, Rotter, Jerome I, Ryten, Mina, Sacco, Ralph L, Sachdev, Perminder S, Saykin, Andrew J, Schmidt, Reinhold, Schofield, Peter R, Sigurdsson, Sigurdur, Simmons, Andy, Singleton, Andrew, Sisodiya, Sanjay M, Smith, Colin, Smoller, Jordan W, Soininen, Hilkka, Srikanth, Velandai, Steen, Vidar M, Stott, David J, Sussmann, Jessika E, Thalamuthu, Anbupalam, Tiemeier, Henning, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Turner, Jessica A, Tzourio, Christophe, Uitterlinden, Andre G, Hernández, Maria C Valdés, Van der Brug, Marcel, Van der Lugt, Aad, Van der Wee, Nic J A, Van Duijn, Cornelia M, Van Haren, Neeltje E M, Van T Ent, Dennis, Van Tol, Marie-Jose, Vardarajan, Badri N, Veltman, Dick J, Vernooij, Meike W, Völzke, Henry, Walter, Henrik, Wardlaw, Joanna M, Wassink, Thomas H, Weale, Michael E, Weinberger, Daniel R, Weiner, Michael W, Wen, Wei, Westman, Eric, White, Tonya, Wong, Tien Y, Wright, Clinton B, Zielke, H Ronald, Zonderman, Alan B, Deary, Ian J, DeCarli, Charles, Schmidt, Helena, Martin, Nicholas G, De Craen, Anton J M, Wright, Margaret J, Launer, Lenore J, Schumann, Gunter, Fornage, Myriam, Franke, Barbara, Debette, Stéphanie, Medland, Sarah E, Ikram, M Arfan, Thompson, Paul M, Adams, Hieab H H, Hibar, Derrek P, Chouraki, Vincent, Stein, Jason L, Nyquist, Paul A, Rentería, Miguel E, Trompet, Stella, Arias-Vasquez, Alejandro, Seshadri, Sudha, Desrivières, Sylvane, Beecham, Ashley H, Jahanshad, Neda, Wittfeld, Katharina, Van der Lee, Sven J, Abramovic, Lucija, Alhusaini, Saud, Amin, Najaf, Andersson, Micael, Arfanakis, Konstantinos, Aribisala, Benjamin S, Armstrong, Nicola J, Athanasiu, Lavinia, Axelsson, Tomas, Beiser, Alexa, Bernard, Manon, Bis, Joshua C, Blanken, Laura M E, Blanton, Susan H, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brickman, Adam M, Carmichael, Owen, Chakravarty, M Mallar, Chauhan, Ganesh, Chen, Qiang, Ching, Christopher R K, Cuellar-Partida, Gabriel, Braber, Anouk Den, Doan, Nhat Trung, Ehrlich, Stefan, Filippi, Irina, Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L, Gottesman, Rebecca F, Greven, Corina U, Grimm, Oliver, Griswold, Michael E, Guadalupe, Tulio, Hass, Johanna, Haukvik, Unn K, Hilal, Saima, Hofer, Edith, Hoehn, David, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kasperaviciute, Dalia, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Liao, Jiemin, Liewald, David C M, Lopez, Lorna M, Luciano, Michelle, Macare, Christine, Marquand, Andre, Matarin, Mar, Mather, Karen A, Mattheisen, Manuel, Mazoyer, Bernard, McKay, David R, McWhirter, Rebekah, Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Muetzel, Ryan L, Maniega, Susana Muñoz, Nho, Kwangsik, Nugent, Allison C, Loohuis, Loes M Olde, Oosterlaan, Jaap, Papmeyer, Martina, Pappa, Irene, Pirpamer, Lukas, Pudas, Sara, Pütz, Benno, Rajan, Kumar B, Ramasamy, Adaikalavan, Richards, Jennifer S, Risacher, Shannon L, Roiz-Santiañez, Roberto, Rommelse, Nanda, Rose, Emma J, Royle, Natalie A, Rundek, Tatjana, Sämann, Philipp G, Satizabal, Claudia L, Schmaal, Lianne, Schork, Andrew J, Shen, Li, Shin, Jean, Shumskaya, Elena, Smith, Albert V, Sprooten, Emma, Strike, Lachlan T, Teumer, Alexander, Thomson, Russell, Tordesillas-Gutierrez, Diana, Toro, Roberto, Trabzuni, Daniah, Vaidya, Dhananjay, Van der Grond, Jeroen, Van der Meer, Dennis, Van Donkelaar, Marjolein M J, Van Eijk, Kristel R, Van Erp, Theo G M, Van Rooij, Daan, Walton, Esther, Westlye, Lars T, Whelan, Christopher D, Windham, Beverly G, Winkler, Anderson M, Woldehawariat, Girma, Wolf, Christiane, Wolfers, Thomas, Xu, Bing, Yanek, Lisa R, Yang, Jingyun, Zijdenbos, Alex, Zwiers, Marcel P, Agartz, Ingrid, Aggarwal, Neelum T, Almasy, Laura, Ames, David, Amouyel, Philippe, Andreassen, Ole A, Arepalli, Sampath, Assareh, Amelia A, Barral, Sandra, Bastin, Mark E, Becker, Diane M, Becker, James T, Bennett, David A, Blangero, John, van Bokhoven, Hans, Boomsma, Dorret I, Brodaty, Henry, Brouwer, Rachel M, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Bulayeva, Kazima B, Cahn, Wiepke, Calhoun, Vince D, Cannon, Dara M, Cavalleri, Gianpiero L, Chen, Christopher, Cheng, Ching-Yu, Cichon, Sven, Cookson, Mark R, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Czisch, Michael, Dale, Anders M, Davies, Gareth E, De Geus, Eco J C, De Jager, Philip L, de Zubicaray, Greig I, Delanty, Norman, Depondt, Chantal, DeStefano, Anita L, Dillman, Allissa, Djurovic, Srdjan, Donohoe, Gary, Drevets, Wayne C, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Espeseth, Thomas, Evans, Denis A, Fedko, Iryna O, Fernández, Guillén, Ferrucci, Luigi, Fisher, Simon E, Fleischman, Debra A, Ford, Ian, Foroud, Tatiana M, Fox, Peter T, Francks, Clyde, Fukunaga, Masaki, Gibbs, J Raphael, Glahn, David C, Gollub, Randy L, Göring, Harald H H, Grabe, Hans J, Green, Robert C, Gruber, Oliver, Gudnason, Vilmundur, Guelfi, Sebastian, Hansell, Narelle K, Hardy, John, Hartman, Catharina A, Hashimoto, Ryota, Hegenscheid, Katrin, Heinz, Andreas, Le Hellard, Stephanie, Hernandez, Dena G, Heslenfeld, Dirk J, Ho, Beng-Choon, Hoekstra, Pieter J, Hoffmann, Wolfgang, Hofman, Albert, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Hottenga, Jouke-Jan, Pol, Hilleke E Hulshoff, Ikeda, Masashi, Ikram, M Kamran, Jack, Clifford R, Jenkinson, Mark, Johnson, Robert, Jönsson, Erik G, Jukema, J Wouter, Kahn, René S, Kanai, Ryota, Kloszewska, Iwona, Knopman, David S, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Lemaître, Hervé, Liu, Xinmin, Longo, Dan L, Longstreth, W T, Lopez, Oscar L, Lovestone, Simon, Martinez, Oliver, Martinot, Jean-Luc, Mattay, Venkata S, McDonald, Colm, McIntosh, Andrew M, McMahon, Katie L, McMahon, Francis J, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mohnke, Sebastian, Montgomery, Grant W, Morris, Derek W, Mosley, Thomas H, Mühleisen, Thomas W, Müller-Myhsok, Bertram, Nalls, Michael A, Nauck, Matthias, Nichols, Thomas E, Niessen, Wiro J, Nöthen, Markus M, Nyberg, Lars, Ohi, Kazutaka, Olvera, Rene L, Ophoff, Roel A, Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W J H, Pike, G Bruce, Potkin, Steven G, Psaty, Bruce M, Reppermund, Simone, Rietschel, Marcella, Roffman, Joshua L, Romanczuk-Seiferth, Nina, Rotter, Jerome I, Ryten, Mina, Sacco, Ralph L, Sachdev, Perminder S, Saykin, Andrew J, Schmidt, Reinhold, Schofield, Peter R, Sigurdsson, Sigurdur, Simmons, Andy, Singleton, Andrew, Sisodiya, Sanjay M, Smith, Colin, Smoller, Jordan W, Soininen, Hilkka, Srikanth, Velandai, Steen, Vidar M, Stott, David J, Sussmann, Jessika E, Thalamuthu, Anbupalam, Tiemeier, Henning, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Turner, Jessica A, Tzourio, Christophe, Uitterlinden, Andre G, Hernández, Maria C Valdés, Van der Brug, Marcel, Van der Lugt, Aad, Van der Wee, Nic J A, Van Duijn, Cornelia M, Van Haren, Neeltje E M, Van T Ent, Dennis, Van Tol, Marie-Jose, Vardarajan, Badri N, Veltman, Dick J, Vernooij, Meike W, Völzke, Henry, Walter, Henrik, Wardlaw, Joanna M, Wassink, Thomas H, Weale, Michael E, Weinberger, Daniel R, Weiner, Michael W, Wen, Wei, Westman, Eric, White, Tonya, Wong, Tien Y, Wright, Clinton B, Zielke, H Ronald, Zonderman, Alan B, Deary, Ian J, DeCarli, Charles, Schmidt, Helena, Martin, Nicholas G, De Craen, Anton J M, Wright, Margaret J, Launer, Lenore J, Schumann, Gunter, Fornage, Myriam, Franke, Barbara, Debette, Stéphanie, Medland, Sarah E, Ikram, M Arfan, and Thompson, Paul M
Published: 2016

27. Novel genetic loci underlying human intracranial volume identified through genome-wide association

Author: Onderzoeksgroep 4, Brain, Risico & Preventie Ond., Onderzoeksgroep 2, Neurogenetica, Onderzoeksgroep 1, Affectieve & Psychotische Med., ZL Cerebrovasculaire Ziekten Medisch, Onderzoek, Adams, Hieab H H, Hibar, Derrek P, Chouraki, Vincent, Stein, Jason L, Nyquist, Paul A, Rentería, Miguel E, Trompet, Stella, Arias-Vasquez, Alejandro, Seshadri, Sudha, Desrivières, Sylvane, Beecham, Ashley H, Jahanshad, Neda, Wittfeld, Katharina, Van der Lee, Sven J, Abramovic, Lucija, Alhusaini, Saud, Amin, Najaf, Andersson, Micael, Arfanakis, Konstantinos, Aribisala, Benjamin S, Armstrong, Nicola J, Athanasiu, Lavinia, Axelsson, Tomas, Beiser, Alexa, Bernard, Manon, Bis, Joshua C, Blanken, Laura M E, Blanton, Susan H, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brickman, Adam M, Carmichael, Owen, Chakravarty, M Mallar, Chauhan, Ganesh, Chen, Qiang, Ching, Christopher R K, Cuellar-Partida, Gabriel, Braber, Anouk Den, Doan, Nhat Trung, Ehrlich, Stefan, Filippi, Irina, Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L, Gottesman, Rebecca F, Greven, Corina U, Grimm, Oliver, Griswold, Michael E, Guadalupe, Tulio, Hass, Johanna, Haukvik, Unn K, Hilal, Saima, Hofer, Edith, Hoehn, David, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kasperaviciute, Dalia, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Liao, Jiemin, Liewald, David C M, Lopez, Lorna M, Luciano, Michelle, Macare, Christine, Marquand, Andre, Matarin, Mar, Mather, Karen A, Mattheisen, Manuel, Mazoyer, Bernard, McKay, David R, McWhirter, Rebekah, Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Muetzel, Ryan L, Maniega, Susana Muñoz, Nho, Kwangsik, Nugent, Allison C, Loohuis, Loes M Olde, Oosterlaan, Jaap, Papmeyer, Martina, Pappa, Irene, Pirpamer, Lukas, Pudas, Sara, Pütz, Benno, Rajan, Kumar B, Ramasamy, Adaikalavan, Richards, Jennifer S, Risacher, Shannon L, Roiz-Santiañez, Roberto, Rommelse, Nanda, Rose, Emma J, Royle, Natalie A, Rundek, Tatjana, Sämann, Philipp G, Satizabal, Claudia L, Schmaal, Lianne, Schork, Andrew J, Shen, Li, Shin, Jean, Shumskaya, Elena, Smith, Albert V, Sprooten, Emma, Strike, Lachlan T, Teumer, Alexander, Thomson, Russell, Tordesillas-Gutierrez, Diana, Toro, Roberto, Trabzuni, Daniah, Vaidya, Dhananjay, Van der Grond, Jeroen, Van der Meer, Dennis, Van Donkelaar, Marjolein M J, Van Eijk, Kristel R, Van Erp, Theo G M, Van Rooij, Daan, Walton, Esther, Westlye, Lars T, Whelan, Christopher D, Windham, Beverly G, Winkler, Anderson M, Woldehawariat, Girma, Wolf, Christiane, Wolfers, Thomas, Xu, Bing, Yanek, Lisa R, Yang, Jingyun, Zijdenbos, Alex, Zwiers, Marcel P, Agartz, Ingrid, Aggarwal, Neelum T, Almasy, Laura, Ames, David, Amouyel, Philippe, Andreassen, Ole A, Arepalli, Sampath, Assareh, Amelia A, Barral, Sandra, Bastin, Mark E, Becker, Diane M, Becker, James T, Bennett, David A, Blangero, John, van Bokhoven, Hans, Boomsma, Dorret I, Brodaty, Henry, Brouwer, Rachel M, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Bulayeva, Kazima B, Cahn, Wiepke, Calhoun, Vince D, Cannon, Dara M, Cavalleri, Gianpiero L, Chen, Christopher, Cheng, Ching-Yu, Cichon, Sven, Cookson, Mark R, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Czisch, Michael, Dale, Anders M, Davies, Gareth E, De Geus, Eco J C, De Jager, Philip L, de Zubicaray, Greig I, Delanty, Norman, Depondt, Chantal, DeStefano, Anita L, Dillman, Allissa, Djurovic, Srdjan, Donohoe, Gary, Drevets, Wayne C, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Espeseth, Thomas, Evans, Denis A, Fedko, Iryna O, Fernández, Guillén, Ferrucci, Luigi, Fisher, Simon E, Fleischman, Debra A, Ford, Ian, Foroud, Tatiana M, Fox, Peter T, Francks, Clyde, Fukunaga, Masaki, Gibbs, J Raphael, Glahn, David C, Gollub, Randy L, Göring, Harald H H, Grabe, Hans J, Green, Robert C, Gruber, Oliver, Gudnason, Vilmundur, Guelfi, Sebastian, Hansell, Narelle K, Hardy, John, Hartman, Catharina A, Hashimoto, Ryota, Hegenscheid, Katrin, Heinz, Andreas, Le Hellard, Stephanie, Hernandez, Dena G, Heslenfeld, Dirk J, Ho, Beng-Choon, Hoekstra, Pieter J, Hoffmann, Wolfgang, Hofman, Albert, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Hottenga, Jouke-Jan, Pol, Hilleke E Hulshoff, Ikeda, Masashi, Ikram, M Kamran, Jack, Clifford R, Jenkinson, Mark, Johnson, Robert, Jönsson, Erik G, Jukema, J Wouter, Kahn, René S, Kanai, Ryota, Kloszewska, Iwona, Knopman, David S, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Lemaître, Hervé, Liu, Xinmin, Longo, Dan L, Longstreth, W T, Lopez, Oscar L, Lovestone, Simon, Martinez, Oliver, Martinot, Jean-Luc, Mattay, Venkata S, McDonald, Colm, McIntosh, Andrew M, McMahon, Katie L, McMahon, Francis J, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mohnke, Sebastian, Montgomery, Grant W, Morris, Derek W, Mosley, Thomas H, Mühleisen, Thomas W, Müller-Myhsok, Bertram, Nalls, Michael A, Nauck, Matthias, Nichols, Thomas E, Niessen, Wiro J, Nöthen, Markus M, Nyberg, Lars, Ohi, Kazutaka, Olvera, Rene L, Ophoff, Roel A, Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W J H, Pike, G Bruce, Potkin, Steven G, Psaty, Bruce M, Reppermund, Simone, Rietschel, Marcella, Roffman, Joshua L, Romanczuk-Seiferth, Nina, Rotter, Jerome I, Ryten, Mina, Sacco, Ralph L, Sachdev, Perminder S, Saykin, Andrew J, Schmidt, Reinhold, Schofield, Peter R, Sigurdsson, Sigurdur, Simmons, Andy, Singleton, Andrew, Sisodiya, Sanjay M, Smith, Colin, Smoller, Jordan W, Soininen, Hilkka, Srikanth, Velandai, Steen, Vidar M, Stott, David J, Sussmann, Jessika E, Thalamuthu, Anbupalam, Tiemeier, Henning, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Turner, Jessica A, Tzourio, Christophe, Uitterlinden, Andre G, Hernández, Maria C Valdés, Van der Brug, Marcel, Van der Lugt, Aad, Van der Wee, Nic J A, Van Duijn, Cornelia M, Van Haren, Neeltje E M, Van T Ent, Dennis, Van Tol, Marie-Jose, Vardarajan, Badri N, Veltman, Dick J, Vernooij, Meike W, Völzke, Henry, Walter, Henrik, Wardlaw, Joanna M, Wassink, Thomas H, Weale, Michael E, Weinberger, Daniel R, Weiner, Michael W, Wen, Wei, Westman, Eric, White, Tonya, Wong, Tien Y, Wright, Clinton B, Zielke, H Ronald, Zonderman, Alan B, Deary, Ian J, DeCarli, Charles, Schmidt, Helena, Martin, Nicholas G, De Craen, Anton J M, Wright, Margaret J, Launer, Lenore J, Schumann, Gunter, Fornage, Myriam, Franke, Barbara, Debette, Stéphanie, Medland, Sarah E, Ikram, M Arfan, Thompson, Paul M, Onderzoeksgroep 4, Brain, Risico & Preventie Ond., Onderzoeksgroep 2, Neurogenetica, Onderzoeksgroep 1, Affectieve & Psychotische Med., ZL Cerebrovasculaire Ziekten Medisch, Onderzoek, Adams, Hieab H H, Hibar, Derrek P, Chouraki, Vincent, Stein, Jason L, Nyquist, Paul A, Rentería, Miguel E, Trompet, Stella, Arias-Vasquez, Alejandro, Seshadri, Sudha, Desrivières, Sylvane, Beecham, Ashley H, Jahanshad, Neda, Wittfeld, Katharina, Van der Lee, Sven J, Abramovic, Lucija, Alhusaini, Saud, Amin, Najaf, Andersson, Micael, Arfanakis, Konstantinos, Aribisala, Benjamin S, Armstrong, Nicola J, Athanasiu, Lavinia, Axelsson, Tomas, Beiser, Alexa, Bernard, Manon, Bis, Joshua C, Blanken, Laura M E, Blanton, Susan H, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brickman, Adam M, Carmichael, Owen, Chakravarty, M Mallar, Chauhan, Ganesh, Chen, Qiang, Ching, Christopher R K, Cuellar-Partida, Gabriel, Braber, Anouk Den, Doan, Nhat Trung, Ehrlich, Stefan, Filippi, Irina, Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L, Gottesman, Rebecca F, Greven, Corina U, Grimm, Oliver, Griswold, Michael E, Guadalupe, Tulio, Hass, Johanna, Haukvik, Unn K, Hilal, Saima, Hofer, Edith, Hoehn, David, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kasperaviciute, Dalia, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Liao, Jiemin, Liewald, David C M, Lopez, Lorna M, Luciano, Michelle, Macare, Christine, Marquand, Andre, Matarin, Mar, Mather, Karen A, Mattheisen, Manuel, Mazoyer, Bernard, McKay, David R, McWhirter, Rebekah, Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Muetzel, Ryan L, Maniega, Susana Muñoz, Nho, Kwangsik, Nugent, Allison C, Loohuis, Loes M Olde, Oosterlaan, Jaap, Papmeyer, Martina, Pappa, Irene, Pirpamer, Lukas, Pudas, Sara, Pütz, Benno, Rajan, Kumar B, Ramasamy, Adaikalavan, Richards, Jennifer S, Risacher, Shannon L, Roiz-Santiañez, Roberto, Rommelse, Nanda, Rose, Emma J, Royle, Natalie A, Rundek, Tatjana, Sämann, Philipp G, Satizabal, Claudia L, Schmaal, Lianne, Schork, Andrew J, Shen, Li, Shin, Jean, Shumskaya, Elena, Smith, Albert V, Sprooten, Emma, Strike, Lachlan T, Teumer, Alexander, Thomson, Russell, Tordesillas-Gutierrez, Diana, Toro, Roberto, Trabzuni, Daniah, Vaidya, Dhananjay, Van der Grond, Jeroen, Van der Meer, Dennis, Van Donkelaar, Marjolein M J, Van Eijk, Kristel R, Van Erp, Theo G M, Van Rooij, Daan, Walton, Esther, Westlye, Lars T, Whelan, Christopher D, Windham, Beverly G, Winkler, Anderson M, Woldehawariat, Girma, Wolf, Christiane, Wolfers, Thomas, Xu, Bing, Yanek, Lisa R, Yang, Jingyun, Zijdenbos, Alex, Zwiers, Marcel P, Agartz, Ingrid, Aggarwal, Neelum T, Almasy, Laura, Ames, David, Amouyel, Philippe, Andreassen, Ole A, Arepalli, Sampath, Assareh, Amelia A, Barral, Sandra, Bastin, Mark E, Becker, Diane M, Becker, James T, Bennett, David A, Blangero, John, van Bokhoven, Hans, Boomsma, Dorret I, Brodaty, Henry, Brouwer, Rachel M, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Bulayeva, Kazima B, Cahn, Wiepke, Calhoun, Vince D, Cannon, Dara M, Cavalleri, Gianpiero L, Chen, Christopher, Cheng, Ching-Yu, Cichon, Sven, Cookson, Mark R, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Czisch, Michael, Dale, Anders M, Davies, Gareth E, De Geus, Eco J C, De Jager, Philip L, de Zubicaray, Greig I, Delanty, Norman, Depondt, Chantal, DeStefano, Anita L, Dillman, Allissa, Djurovic, Srdjan, Donohoe, Gary, Drevets, Wayne C, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Espeseth, Thomas, Evans, Denis A, Fedko, Iryna O, Fernández, Guillén, Ferrucci, Luigi, Fisher, Simon E, Fleischman, Debra A, Ford, Ian, Foroud, Tatiana M, Fox, Peter T, Francks, Clyde, Fukunaga, Masaki, Gibbs, J Raphael, Glahn, David C, Gollub, Randy L, Göring, Harald H H, Grabe, Hans J, Green, Robert C, Gruber, Oliver, Gudnason, Vilmundur, Guelfi, Sebastian, Hansell, Narelle K, Hardy, John, Hartman, Catharina A, Hashimoto, Ryota, Hegenscheid, Katrin, Heinz, Andreas, Le Hellard, Stephanie, Hernandez, Dena G, Heslenfeld, Dirk J, Ho, Beng-Choon, Hoekstra, Pieter J, Hoffmann, Wolfgang, Hofman, Albert, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Hottenga, Jouke-Jan, Pol, Hilleke E Hulshoff, Ikeda, Masashi, Ikram, M Kamran, Jack, Clifford R, Jenkinson, Mark, Johnson, Robert, Jönsson, Erik G, Jukema, J Wouter, Kahn, René S, Kanai, Ryota, Kloszewska, Iwona, Knopman, David S, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Lemaître, Hervé, Liu, Xinmin, Longo, Dan L, Longstreth, W T, Lopez, Oscar L, Lovestone, Simon, Martinez, Oliver, Martinot, Jean-Luc, Mattay, Venkata S, McDonald, Colm, McIntosh, Andrew M, McMahon, Katie L, McMahon, Francis J, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mohnke, Sebastian, Montgomery, Grant W, Morris, Derek W, Mosley, Thomas H, Mühleisen, Thomas W, Müller-Myhsok, Bertram, Nalls, Michael A, Nauck, Matthias, Nichols, Thomas E, Niessen, Wiro J, Nöthen, Markus M, Nyberg, Lars, Ohi, Kazutaka, Olvera, Rene L, Ophoff, Roel A, Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W J H, Pike, G Bruce, Potkin, Steven G, Psaty, Bruce M, Reppermund, Simone, Rietschel, Marcella, Roffman, Joshua L, Romanczuk-Seiferth, Nina, Rotter, Jerome I, Ryten, Mina, Sacco, Ralph L, Sachdev, Perminder S, Saykin, Andrew J, Schmidt, Reinhold, Schofield, Peter R, Sigurdsson, Sigurdur, Simmons, Andy, Singleton, Andrew, Sisodiya, Sanjay M, Smith, Colin, Smoller, Jordan W, Soininen, Hilkka, Srikanth, Velandai, Steen, Vidar M, Stott, David J, Sussmann, Jessika E, Thalamuthu, Anbupalam, Tiemeier, Henning, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Turner, Jessica A, Tzourio, Christophe, Uitterlinden, Andre G, Hernández, Maria C Valdés, Van der Brug, Marcel, Van der Lugt, Aad, Van der Wee, Nic J A, Van Duijn, Cornelia M, Van Haren, Neeltje E M, Van T Ent, Dennis, Van Tol, Marie-Jose, Vardarajan, Badri N, Veltman, Dick J, Vernooij, Meike W, Völzke, Henry, Walter, Henrik, Wardlaw, Joanna M, Wassink, Thomas H, Weale, Michael E, Weinberger, Daniel R, Weiner, Michael W, Wen, Wei, Westman, Eric, White, Tonya, Wong, Tien Y, Wright, Clinton B, Zielke, H Ronald, Zonderman, Alan B, Deary, Ian J, DeCarli, Charles, Schmidt, Helena, Martin, Nicholas G, De Craen, Anton J M, Wright, Margaret J, Launer, Lenore J, Schumann, Gunter, Fornage, Myriam, Franke, Barbara, Debette, Stéphanie, Medland, Sarah E, Ikram, M Arfan, and Thompson, Paul M
Published: 2016

28. P4-146: Large-Vessel Disease and [18F]Flutemetamol-Amyloid Deposition in Cognitively Healthy Elderly Twins

Author: Vermunt, Lisa, primary, Konijnenberg, Elles, additional, Kate, Mara ten, additional, Braber, Anouk den, additional, Yaqub, Maqsood M., additional, Serné, Erik, additional, Boomsma, Dorret I., additional, Scheltens, Philip, additional, van Berckel, Bart N.M., additional, and Visser, Pieter Jelle, additional
Published: 2016
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29. P2-237: Concordance of [18F] Flutemetamol Amyloid Deposition in Cognitively Healthy Elderly Monozygotic Twin Pairs

Author: Konijnenberg, Elles, primary, Braber, Anouk den, additional, Kate, Mara ten, additional, Adriaanse, Sofie, additional, Yaqub, Maqsood M., additional, Boomsma, Dorret I., additional, Scheltens, Philip, additional, van Berckel, Bart N.M., additional, and Visser, Pieter Jelle, additional
Published: 2016
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30. IC-02-04: Correlation of Cortical Thickness in Cognitively Healthy Elderly Monozygotic Twin Pairs

Author: Braber, Anouk den, primary, Konijnenberg, Elles, additional, Kate, Mara ten, additional, Tijms, Betty M., additional, Barkhof, Frederik, additional, Boomsma, Dorret I., additional, Scheltens, Philip, additional, and Visser, Pieter Jelle, additional
Published: 2016
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31. P3-269: Correlation of Cortical Thickness in Cognitively Healthy Elderly Monozygotic Twin Pairs

Author: Braber, Anouk den, primary, Konijnenberg, Elles, additional, Kate, Mara ten, additional, Tijms, Betty M., additional, Barkhof, Frederik, additional, Boomsma, Dorret I., additional, Scheltens, Philip, additional, and Visser, Pieter Jelle, additional
Published: 2016
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32. EVENT-BASED MODELING OF THE TEMPORAL ORDERING OF REGIONAL β-AMYLOID DEPOSITION IN THE BRAIN

Author: Alves, Isadora Lopes, Collij, Lyduine, Heeman, Fiona, Wottschel, Viktor, Konijnenberg, Elles, Braber, Anouk den, Yaqub, Maqsood M., Boellaard, Ronald, Visser, Pieter Jelle, van Berckel, Bart N.M., Scheltens, Philip, Schmidt, Mark E., and Barkhof, Frederik
Published: 2018
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33. WHITE MATTER MICROSTRUCTURE AND AMYLOID AGGREGATION IN COGNITIVELY HEALTHY, ELDERLY IDENTICAL TWINS

Author: Braber, Anouk den, Stickney, Kristine, Ent, Dennis van 't, Kate, Mara ten, Konijnenberg, Elles, Tomassen, Jori, Barkhof, Frederik, van Berckel, Bart N.M., Boomsma, Dorret I., de Geus, Eco, Scheltens, Philip, and Visser, Pieter Jelle
Published: 2018
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34. CORRELATION OF GREY MATTER NETWORK MEASURES IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS

Author: Kate, Mara ten, Tijms, Betty M., Konijnenberg, Elles, Braber, Anouk den, Boomsma, Dorret I., Scheltens, Philip, Barkhof, Frederik, and Visser, Pieter Jelle
Published: 2017
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35. WHITE MATTER HYPERINTENSITIES AND VASCULAR RISK FACTORS IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS

Author: Kate, Mara ten, Sudre, Carole H., Braber, Anouk den, Konijnenberg, Elles, Cardoso, M. Jorge, Scheltens, Philip, Ourselin, Sebastien, Boomsma, Dorret I., Barkhof, Frederik, and Visser, Pieter Jelle
Published: 2017
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36. EARLY ALTERATIONS IN RESTING-STATE FUNCTIONAL CONNECTIVITY IS ASSOCIATED WITH AMYLOID PATHOLOGY IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWINS

Author: Braber, Anouk den, Prent, Naomi, Kate, Mara ten, Konijnenberg, Elles, Barkhof, Frederik, van Berckel, Bart N.M., Scheltens, Philip, Boomsma, Dorret I., and Visser, Pieter Jelle
Published: 2017
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37. LARGE-VESSEL DISEASE AND [18F]FLUTEMETAMOL-AMYLOID DEPOSITION IN COGNITIVELY HEALTHY ELDERLY TWINS

Author: Vermunt, Lisa, Konijnenberg, Elles, Kate, Mara ten, Braber, Anouk den, Yaqub, Maqsood M., Serné, Erik, Boomsma, Dorret I., Scheltens, Philip, van Berckel, Bart N.M., and Visser, Pieter Jelle
Published: 2016
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38. CORRELATION OF CORTICAL THICKNESS IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS

Author: Braber, Anouk den, Konijnenberg, Elles, Kate, Mara ten, Tijms, Betty M., Barkhof, Frederik, Boomsma, Dorret I., Scheltens, Philip, and Visser, Pieter Jelle
Published: 2016
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39. CONCORDANCE OF [18F]FLUTEMETAMOL AMYLOID DEPOSITION IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS

Author: Konijnenberg, Elles, Braber, Anouk den, Kate, Mara ten, Adriaanse, Sofie, Yaqub, Maqsood M., Boomsma, Dorret I., Scheltens, Philip, van Berckel, Bart N.M., and Visser, Pieter Jelle
Published: 2016
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40. The Amsterdam Resting-State Questionnaire reveals multiple phenotypes of resting-state cognition.

Author: Diaz, B. Alexander, Van Der Sluis, Sophie, Moens, Sarah, Benjamins, Jeroen S., Migliorati, Filippo, Stoffers, Diederick, Braber, Anouk Den, Poil, Simon-Shlomo, Hardstone, Richard, Ent, Dennis Van't, Boomsma, Dorret I., De Geusz, Eco, Mansvelder, Huibert D., Van Someren, Eus J. W., and Linkenkaer-Hansen, Klaus
Subjects: GENOTYPE-environment interaction, ELECTROENCEPHALOGRAPHY, PHENOTYPES, PRESENILE dementia, DISEASES in older people
Abstract: Resting-state neuroimaging is a dominant paradigm for studying brain function in health and disease. It is attractive for clinical research because of its simplicity for patients, straightforward standardization, and sensitivity to brain disorders. Importantly, non-sensory experiences like mind wandering may arise from ongoing brain activity. However, little is known about the link between ongoing brain activity and cognition, as phenotypes of resting-state cognition-and tools to quantify them-have been lacking. To facilitate rapid and structured measurements of resting-state cognition we developed a 50-item self-report survey, the Amsterdam Resting-State Questionnaire (ARSQ). Based on ARSQ data from 813 participants assessed after 5min eyes-closed rest in their home, we identified seven dimensions of resting-state cognition using factor analysis: Discontinuity of Mind, Theory of Mind, Self, Planning, Sleepiness, Comfort, and Somatic Awareness. Further, we showed that the structure of cognition was similar during resting-state fMRI and EEG, and that the test-retest correlations were remarkably high for all dimensions. To explore whether inter-individual variation of resting-state cognition is related to health status, we correlated ARSQ-derived factor scores with psychometric scales measuring depression, anxiety, and sleep quality. Mental health correlated positively with Comfort and negatively with Discontinuity of Mind. Finally, we show that sleepiness may partially explain a resting-state EEG profile previously associated with Alzheimer's disease. These findings indicate that the ARSQ readily provides information about cognitive phenotypes and that it is a promising tool for research on the neural correlates of resting-state cognition in health and disease. [ABSTRACT FROM AUTHOR]
Published: 2013
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41. Additional file 4: of The EMIF-AD PreclinAD study: study design and baseline cohort overview

Author: Konijnenberg, Elles, Carter, Stephen, Kate, Mara Ten, Braber, Anouk Den, Tomassen, Jori, Chinenye Amadi, Wesselman, Linda, Hoang-Ton Nguyen, Kreeke, Jacoba Van De, Yaqub, Maqsood, Demuru, Matteo, Mulder, Sandra, Hillebrand, Arjan, Bouwman, Femke, Teunissen, Charlotte, SernĂŠ, Erik, Moll, Annette, Verbraak, Frank, Hinz, Rainer, Pendleton, Neil, Lammertsma, Adriaan, Berckel, Bart Van, Barkhof, Frederik, Dorret Boomsma, Scheltens, Philip, Herholz, Karl, and Visser, Pieter
Subjects: 3. Good health
Abstract: Table S4. Biomarkers baseline. (DOCX 24Â kb)

42. Additional file 5: of The EMIF-AD PreclinAD study: study design and baseline cohort overview

Author: Konijnenberg, Elles, Carter, Stephen, Kate, Mara Ten, Braber, Anouk Den, Tomassen, Jori, Chinenye Amadi, Wesselman, Linda, Hoang-Ton Nguyen, Kreeke, Jacoba Van De, Yaqub, Maqsood, Demuru, Matteo, Mulder, Sandra, Hillebrand, Arjan, Bouwman, Femke, Teunissen, Charlotte, SernĂŠ, Erik, Moll, Annette, Verbraak, Frank, Hinz, Rainer, Pendleton, Neil, Lammertsma, Adriaan, Berckel, Bart Van, Barkhof, Frederik, Dorret Boomsma, Scheltens, Philip, Herholz, Karl, and Visser, Pieter
Subjects: 3. Good health
Abstract: Table S5. MRI settings. (DOCX 15Â kb)

43. Additional file 5: of The EMIF-AD PreclinAD study: study design and baseline cohort overview

Author: Konijnenberg, Elles, Carter, Stephen, Kate, Mara Ten, Braber, Anouk Den, Tomassen, Jori, Chinenye Amadi, Wesselman, Linda, Hoang-Ton Nguyen, Kreeke, Jacoba Van De, Yaqub, Maqsood, Demuru, Matteo, Mulder, Sandra, Hillebrand, Arjan, Bouwman, Femke, Teunissen, Charlotte, SernĂŠ, Erik, Moll, Annette, Verbraak, Frank, Hinz, Rainer, Pendleton, Neil, Lammertsma, Adriaan, Berckel, Bart Van, Barkhof, Frederik, Dorret Boomsma, Scheltens, Philip, Herholz, Karl, and Visser, Pieter
Subjects: 3. Good health
Abstract: Table S5. MRI settings. (DOCX 15Â kb)

44. Additional file 4: of The EMIF-AD PreclinAD study: study design and baseline cohort overview

Author: Konijnenberg, Elles, Carter, Stephen, Kate, Mara Ten, Braber, Anouk Den, Tomassen, Jori, Chinenye Amadi, Wesselman, Linda, Hoang-Ton Nguyen, Kreeke, Jacoba Van De, Yaqub, Maqsood, Demuru, Matteo, Mulder, Sandra, Hillebrand, Arjan, Bouwman, Femke, Teunissen, Charlotte, SernĂŠ, Erik, Moll, Annette, Verbraak, Frank, Hinz, Rainer, Pendleton, Neil, Lammertsma, Adriaan, Berckel, Bart Van, Barkhof, Frederik, Dorret Boomsma, Scheltens, Philip, Herholz, Karl, and Visser, Pieter
Subjects: 3. Good health
Abstract: Table S4. Biomarkers baseline. (DOCX 24Â kb)

45. Additional file 2: of The EMIF-AD PreclinAD study: study design and baseline cohort overview

Author: Konijnenberg, Elles, Carter, Stephen, Kate, Mara Ten, Braber, Anouk Den, Tomassen, Jori, Chinenye Amadi, Wesselman, Linda, Hoang-Ton Nguyen, Kreeke, Jacoba Van De, Yaqub, Maqsood, Demuru, Matteo, Mulder, Sandra, Hillebrand, Arjan, Bouwman, Femke, Teunissen, Charlotte, SernĂŠ, Erik, Moll, Annette, Verbraak, Frank, Hinz, Rainer, Pendleton, Neil, Lammertsma, Adriaan, Berckel, Bart Van, Barkhof, Frederik, Dorret Boomsma, Scheltens, Philip, Herholz, Karl, and Visser, Pieter
Subjects: 3. Good health
Abstract: Table S2. Neuropsychological tests baseline. (DOCX 48Â kb)

46. Additional file 2: of The EMIF-AD PreclinAD study: study design and baseline cohort overview

Author: Konijnenberg, Elles, Carter, Stephen, Kate, Mara Ten, Braber, Anouk Den, Tomassen, Jori, Chinenye Amadi, Wesselman, Linda, Hoang-Ton Nguyen, Kreeke, Jacoba Van De, Yaqub, Maqsood, Demuru, Matteo, Mulder, Sandra, Hillebrand, Arjan, Bouwman, Femke, Teunissen, Charlotte, SernĂŠ, Erik, Moll, Annette, Verbraak, Frank, Hinz, Rainer, Pendleton, Neil, Lammertsma, Adriaan, Berckel, Bart Van, Barkhof, Frederik, Dorret Boomsma, Scheltens, Philip, Herholz, Karl, and Visser, Pieter
Subjects: 3. Good health
Abstract: Table S2. Neuropsychological tests baseline. (DOCX 48Â kb)

47. Amyloid burden and vascular risk factors correlate with regional cerebral blood flow in a cognitively unimpaired population

Author: Padrela, Beatriz, primary, Lorenzini, Luigi, additional, Collij, Lyduine, additional, Kate, Mara ten, additional, Braber, Anouk den, additional, Tomassen, Jori, additional, van Beckel, Bart, additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, Petr, Jan, additional, and Mutsaerts, Henk, additional
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48. White matter microstructure disruption in early stage amyloid pathology.

Author: Collij LE, Ingala S, Top H, Wottschel V, Stickney KE, Tomassen J, Konijnenberg E, Ten Kate M, Sudre C, Lopes Alves I, Yaqub MM, Wink AM, Van 't Ent D, Scheltens P, van Berckel BNM, Visser PJ, Barkhof F, and Braber AD
Abstract: Introduction: Amyloid beta (Aβ) accumulation is the first pathological hallmark of Alzheimer's disease (AD), and it is associated with altered white matter (WM) microstructure. We aimed to investigate this relationship at a regional level in a cognitively unimpaired cohort., Methods: We included 179 individuals from the European Medical Information Framework for AD (EMIF-AD) preclinAD study, who underwent diffusion magnetic resonance (MR) to determine tract-level fractional anisotropy (FA); mean, radial, and axial diffusivity (MD/RD/AxD); and dynamic [ 18 F]flutemetamol) positron emission tomography (PET) imaging to assess amyloid burden., Results: Regression analyses showed a non-linear relationship between regional amyloid burden and WM microstructure. Low amyloid burden was associated with increased FA and decreased MD/RD/AxD, followed by decreased FA and increased MD/RD/AxD upon higher amyloid burden. The strongest association was observed between amyloid burden in the precuneus and body of the corpus callosum (CC) FA and diffusivity (MD/RD) measures. In addition, amyloid burden in the anterior cingulate cortex strongly related to AxD and RD measures in the genu CC., Discussion: Early amyloid deposition is associated with changes in WM microstructure. The non-linear relationship might reflect multiple stages of axonal damage., (© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.)
Published: 2021
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49. Assessing Amyloid Pathology in Cognitively Normal Subjects Using 18 F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods.

Author: Collij LE, Konijnenberg E, Reimand J, Kate MT, Braber AD, Lopes Alves I, Zwan M, Yaqub M, van Assema DME, Wink AM, Lammertsma AA, Scheltens P, Visser PJ, Barkhof F, and van Berckel BNM
Subjects: Aged, Alzheimer Disease physiopathology, Female, Humans, Male, Alzheimer Disease diagnostic imaging, Aniline Compounds, Benzothiazoles, Cognition, Image Processing, Computer-Assisted methods, Positron-Emission Tomography
Abstract: Our objective was to determine the optimal approach for assessing amyloid disease in a cognitively normal elderly population. Methods: Dynamic 18 F-flutemetamol PET scans were acquired using a coffee-break protocol (a 0- to 30-min scan and a 90- to 110-min scan) on 190 cognitively normal elderly individuals (mean age, 70.4 y; 60% female). Parametric images were generated from SUV ratio (SUVr) and nondisplaceable binding potential (BP ND ) methods, with cerebellar gray matter as a reference region, and were visually assessed by 3 trained readers. Interreader agreement was calculated using κ-statistics, and semiquantitative values were obtained. Global cutoffs were calculated for both SUVr and BP ND using a receiver-operating-characteristic analysis and the Youden index. Visual assessment was related to semiquantitative classifications. Results: Interreader agreement in visual assessment was moderate for SUVr (κ = 0.57) and good for BP ND images (κ = 0.77). There was discordance between readers for 35 cases (18%) using SUVr and for 15 cases (8%) using BP ND , with 9 overlapping cases. For the total cohort, the mean (±SD) SUVr and BP ND were 1.33 (±0.21) and 0.16 (±0.12), respectively. Most of the 35 cases (91%) for which SUVr image assessment was discordant between readers were classified as negative based on semiquantitative measurements. Conclusion: The use of parametric BP ND images for visual assessment of 18 F-flutemetamol in a population with low amyloid burden improves interreader agreement. Implementing semiquantification in addition to visual assessment of SUVr images can reduce false-positive classification in this population., (© 2019 by the Society of Nuclear Medicine and Molecular Imaging.)
Published: 2019
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