3,431 results on '"Braber, A."'
Search Results
2. Food-sourcing from on-farm trees mediates positive relationships between tree cover and dietary quality in Malawi
- Author
-
Vansant, Emilie, den Braber, Bowy, Hall, Charlotte, Kamoto, Judith, Reiner, Florian, Oldekop, Johan, and Rasmussen, Laura Vang
- Published
- 2024
- Full Text
- View/download PDF
3. Socio-economic and environmental trade-offs in Amazonian protected areas and Indigenous territories revealed by assessing competing land uses
- Author
-
den Braber, Bowy, Oldekop, Johan A., Devenish, Katie, Godar, Javier, Nolte, Christoph, Schmoeller, Marina, and Evans, Karl L.
- Published
- 2024
- Full Text
- View/download PDF
4. The importance of different forest management systems for people’s dietary quality in Tanzania
- Author
-
Olesen, R. S., Reiner, F., den Braber, B., Hall, C., Kilawe, C. J., Kinabo, J., Msuya, J., and Rasmussen, L. V.
- Published
- 2024
- Full Text
- View/download PDF
5. Amyloid-PET imaging predicts functional decline in clinically normal individuals
- Author
-
Quenon, Lisa, Collij, Lyduine E., Garcia, David Vállez, Lopes Alves, Isadora, Gérard, Thomas, Malotaux, Vincent, Huyghe, Lara, Gispert, Juan Domingo, Jessen, Frank, Visser, Pieter Jelle, den Braber, Anouk, Ritchie, Craig W., Boada, Mercè, Marquié, Marta, Vandenberghe, Rik, Luckett, Emma S., Schöll, Michael, Frisoni, Giovanni B., Buckley, Christopher, Stephens, Andrew, Altomare, Daniele, Ford, Lisa, Birck, Cindy, Mett, Anja, Gismondi, Rossella, Wolz, Robin, Grootoonk, Sylke, Manber, Richard, Shekari, Mahnaz, Lhommel, Renaud, Dricot, Laurence, Ivanoiu, Adrian, Farrar, Gill, Barkhof, Frederik, and Hanseeuw, Bernard J.
- Published
- 2024
- Full Text
- View/download PDF
6. Amyloid-PET imaging predicts functional decline in clinically normal individuals
- Author
-
Lisa Quenon, Lyduine E. Collij, David Vállez Garcia, Isadora Lopes Alves, Thomas Gérard, Vincent Malotaux, Lara Huyghe, Juan Domingo Gispert, Frank Jessen, Pieter Jelle Visser, Anouk den Braber, Craig W. Ritchie, Mercè Boada, Marta Marquié, Rik Vandenberghe, Emma S. Luckett, Michael Schöll, Giovanni B. Frisoni, Christopher Buckley, Andrew Stephens, Daniele Altomare, Lisa Ford, Cindy Birck, Anja Mett, Rossella Gismondi, Robin Wolz, Sylke Grootoonk, Richard Manber, Mahnaz Shekari, Renaud Lhommel, Laurence Dricot, Adrian Ivanoiu, Gill Farrar, Frederik Barkhof, Bernard J. Hanseeuw, and the AMYPAD Consortium
- Subjects
Amyloid-PET ,Centiloid ,Preclinical Alzheimer ,Functional decline ,Instrumental activities of daily living ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background There is good evidence that elevated amyloid-β (Aβ) positron emission tomography (PET) signal is associated with cognitive decline in clinically normal (CN) individuals. However, it is less well established whether there is an association between the Aβ burden and decline in daily living activities in this population. Moreover, Aβ-PET Centiloids (CL) thresholds that can optimally predict functional decline have not yet been established. Methods Cross-sectional and longitudinal analyses over a mean three-year timeframe were performed on the European amyloid-PET imaging AMYPAD-PNHS dataset that phenotypes 1260 individuals, including 1032 CN individuals and 228 participants with questionable functional impairment. Amyloid-PET was assessed continuously on the Centiloid (CL) scale and using Aβ groups (CL 50 = Aβ+). Functional abilities were longitudinally assessed using the Clinical Dementia Rating (Global-CDR, CDR-SOB) and the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q). The Global-CDR was available for the 1260 participants at baseline, while baseline CDR-SOB and A-IADL-Q scores and longitudinal functional data were available for different subsamples that had similar characteristics to those of the entire sample. Results Participants included 765 Aβ- (61%, Mdn age = 66.0, IQR age = 61.0–71.0; 59% women), 301 Aβ± (24%; Mdn age = 69.0, IQR age = 64.0–75.0; 53% women) and 194 Aβ+ individuals (15%, Mdn age = 73.0, IQR age = 68.0–78.0; 53% women). Cross-sectionally, CL values were associated with CDR outcomes. Longitudinally, baseline CL values predicted prospective changes in the CDR-SOB (b CL*Time = 0.001/CL/year, 95% CI [0.0005,0.0024], p = .003) and A-IADL-Q (b CL*Time = -0.010/CL/year, 95% CI [-0.016,-0.004], p = .002) scores in initially CN participants. Increased clinical progression (Global-CDR > 0) was mainly observed in Aβ+ CN individuals (HR Aβ+ vs Aβ- = 2.55, 95% CI [1.16,5.60], p = .020). Optimal thresholds for predicting decline were found at 41 CL using the CDR-SOB (b Aβ+ vs Aβ- = 0.137/year, 95% CI [0.069,0.206], p
- Published
- 2024
- Full Text
- View/download PDF
7. Effects of nondigestible oligosaccharides on inflammation, lung health, and performance of calves
- Author
-
M.S. Gilbert, Y. Cai, G. Folkerts, S. Braber, and W.J.J. Gerrits
- Subjects
calf ,oligosaccharides ,lung health ,inflammation ,Dairy processing. Dairy products ,SF250.5-275 ,Dairying ,SF221-250 - Abstract
ABSTRACT: Our objective was to determine the effects of nondigestible oligosaccharides (NDO) on lung health and performance. Three hundred male Holstein-Friesian calves aged 18.0 ± 3.6 d received 1 of 6 treatments for 8.5 wk (period 1). Treatments included a negative control (CON), galacto-oligosaccharides (GOS) administered as a spray via the nose once daily (SPR), GOS administered via the milk replacer (MR) at 1% (GOS-L) and 2% (GOS-H), fructo-oligosaccharides administered via the MR at 0.25% (FOS) and a combination of GOS and fructo-oligosaccharides administered via the MR at 1% and 0.25%, respectively (GOS-FOS). Milk replacer was fed twice daily. Feeding levels were equal between calves and increased progressively in time. Body weight was measured every 4 wk and clinical health was scored weekly. Blood and broncho-alveolar lavage fluid (BALF) samples were collected bi-weekly from a subset of calves (n = 120). After period 1, all calves received the same control MR for 18 wk until slaughter (period 2), during which general performance and clinical health were measured. Generally, infection pressure was high, with clinical scores and BALF proinflammatory TNFα concentrations increasing with time in period 1, which resulted in a high number of required group antimicrobial treatments (6 group antimicrobial treatments in 13 wk, supplied to all calves). Average daily gain adjusted to equal solid feed intake was increased for GOS-L (+61 g/d) compared with CON calves from experimental wk 1 to 5. Plasma white blood cell concentration tended to be lowered by GOS-L, plasma IL-8 concentration was reduced by all orally supplemented NDO, plasma IL-6 was reduced by all NDO treatments except GOS-FOS and plasma IL-1β was reduced by all NDO treatments compared with CON, although this differed per time point for SPR. The neutrophil percentage in BALF was reduced by GOS-L in wk 6, which was associated with a relative increase in macrophages. The BALF concentration of TNFα and IL-8 was reduced or tended to be reduced by GOS-L and GOS-H, while IL-6 was or tended to be reduced by SPR, GOS-L, GOS-H, and GOS-FOS, and IL-1β was reduced by SPR, GOS-L, GOS-H, and FOS. Generally, feeding the combination of GOS and FOS was not more effective than feeding GOS or FOS alone, because feeding GOS-FOS resulted in higher concentrations of plasma and BALF cytokine and chemokine concentrations compared with feeding GOS-L alone, and resulted in higher plasma cytokine concentrations compared with feeding FOS alone. None of the BALF and plasma cytokine or chemokine concentrations differed between the GOS-L and GOS-H treatment. Performance and clinical scores in period 2 did not differ among treatments. Altogether, all tested NDO reduced systemic and lung inflammation in calves under high natural infection pressure and for GOS-fed calves, this increased performance during the first 4 wk. Combining GOS and FOS did not have a synergistic effect. The intranasal administration of GOS also lowered systemic and lung inflammation, but tended to negatively affect performance. Overall, this study demonstrates the potential of NDO to alleviate systemic and respiratory inflammation in calves.
- Published
- 2024
- Full Text
- View/download PDF
8. ALCAPA syndrome, a rare cause of sudden cardiac death
- Author
-
Rehman, Muniebur, Braber, Thijs, Mouden, Mohamed, Knollema, Siert, and Güçlü, Ahmet
- Published
- 2024
- Full Text
- View/download PDF
9. Replaying the Past: Belgian Pop Band dEUS’s Return to Early Work
- Author
-
van den Braber, Helleke, Gieskes, Mette, editor, and Roza, Mathilde, editor
- Published
- 2024
- Full Text
- View/download PDF
10. Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles
- Author
-
Tijms, Betty M., Vromen, Ellen M., Mjaavatten, Olav, Holstege, Henne, Reus, Lianne M., van der Lee, Sven, Wesenhagen, Kirsten E. J., Lorenzini, Luigi, Vermunt, Lisa, Venkatraghavan, Vikram, Tesi, Niccoló, Tomassen, Jori, den Braber, Anouk, Goossens, Julie, Vanmechelen, Eugeen, Barkhof, Frederik, Pijnenburg, Yolande A. L., van der Flier, Wiesje M., Teunissen, Charlotte E., Berven, Frode S., and Visser, Pieter Jelle
- Published
- 2024
- Full Text
- View/download PDF
11. Consequences of Data Loss on Clinical Decision-Making in Continuous Glucose Monitoring: Retrospective Cohort Study
- Author
-
Niala den Braber, Carlijn I R Braem, Miriam M R Vollenbroek-Hutten, Hermie J Hermens, Thomas Urgert, Utku S Yavuz, Peter H Veltink, and Gozewijn D Laverman
- Subjects
Computer applications to medicine. Medical informatics ,R858-859.7 ,Medical technology ,R855-855.5 - Abstract
BackgroundThe impact of missing data on individual continuous glucose monitoring (CGM) data is unknown but can influence clinical decision-making for patients. ObjectiveWe aimed to investigate the consequences of data loss on glucose metrics in individual patient recordings from continuous glucose monitors and assess its implications on clinical decision-making. MethodsThe CGM data were collected from patients with type 1 and 2 diabetes using the FreeStyle Libre sensor (Abbott Diabetes Care). We selected 7-28 days of 24 hours of continuous data without any missing values from each individual patient. To mimic real-world data loss, missing data ranging from 5% to 50% were introduced into the data set. From this modified data set, clinical metrics including time below range (TBR), TBR level 2 (TBR2), and other common glucose metrics were calculated in the data sets with and that without data loss. Recordings in which glucose metrics deviated relevantly due to data loss, as determined by clinical experts, were defined as expert panel boundary error (εEPB). These errors were expressed as a percentage of the total number of recordings. The errors for the recordings with glucose management indicator
- Published
- 2024
- Full Text
- View/download PDF
12. Human Milk Oligosaccharides in Combination with Galacto- and Long-Chain Fructo-Oligosaccharides Enhance Vaccination Efficacy in a Murine Influenza Vaccination Model
- Author
-
Mehrdad Azarmi, Negisa Seyed Toutounchi, Astrid Hogenkamp, Suzan Thijssen, Saskia A. Overbeek, Johan Garssen, Gert Folkerts, Belinda van’t Land, and Saskia Braber
- Subjects
B lymphocytes ,fructo-oligosaccharides ,galacto-oligosaccharides ,human milk oligosaccharides ,prebiotics ,T helper 1 immune response ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Early-life nutrition significantly impacts vaccination efficacy in infants, whose immune response to vaccines is weaker compared to adults. This study investigated vaccination efficacy in female C57Bl/6JOlaHsd mice (6 weeks old) fed diets with 0.7% galacto-oligosaccharides (GOS)/long-chain fructo-oligosaccharides (lcFOS) (9:1), 0.3% human milk oligosaccharides (HMOS), or a combination (GFH) for 14 days prior to and during vaccination. Delayed-type hypersensitivity (DTH) was measured by assessing ear swelling following an intradermal challenge. Influvac-specific IgG1 and IgG2a levels were assessed using ELISAs, while splenic T and B lymphocytes were analyzed for frequency and activation via flow cytometry. Additionally, cytokine production was evaluated using murine splenocytes co-cultured with influenza-loaded dendritic cells. Mice on the GFH diet showed a significantly enhanced DTH response (p < 0.05), increased serological IgG1 levels, and a significant rise in memory B lymphocytes (CD27+ B220+ CD19+). GFH-fed mice also exhibited more activated splenic Th1 cells (CD69+ CXCR3+ CD4+) and higher IFN-γ production after ex vivo restimulation (p < 0.05). These findings suggest that GOS/lcFOS and HMOS, particularly in combination, enhance vaccine responses by improving memory B cells, IgG production, and Th1 cell activation, supporting the potential use of these prebiotics in infant formula for better early-life immune development.
- Published
- 2024
- Full Text
- View/download PDF
13. A monodispersed metal-complexing peptide-based polymer for mass cytometry enabling spectral applications
- Author
-
Verhoeff, Jan, van Asten, Saskia, Kuijper, Lisan, van den Braber, Marlous, Amstalden-van Hove, Erika, Haselberg, Rob, Kalay, Hakan, and Garcia-Vallejo, Juan J.
- Published
- 2024
- Full Text
- View/download PDF
14. What shapes yields of East African Highland banana? An explorative study from farmers’ fields
- Author
-
den Braber, Harmen, van de Ven, Gerrie, van Heerwaarden, Joost, Marinus, Wytze, Ronner, Esther, Descheemaeker, Katrien, and Taulya, Godfrey
- Published
- 2024
- Full Text
- View/download PDF
15. Effects of nondigestible oligosaccharides on inflammation, lung health, and performance of calves
- Author
-
Gilbert, M.S., Cai, Y., Folkerts, G., Braber, S., and Gerrits, W.J.J.
- Published
- 2024
- Full Text
- View/download PDF
16. Forest regrowth improves people’s dietary quality in Nigeria
- Author
-
Rasmussen, Laura Vang, den Braber, Bowy, Hall, Charlotte M., Rhemtulla, Jeanine M., Fagan, Matthew E., and Sunderland, Terry
- Published
- 2023
- Full Text
- View/download PDF
17. Wild foods contribute to women’s higher dietary diversity in India
- Author
-
Cheek, Jennifer Zavaleta, Lambrecht, Nathalie J., den Braber, Bowy, Akanchha, Nirali, Govindarajulu, Dhanapal, Jones, Andrew D., Chhatre, Ashwini, and Rasmussen, Laura Vang
- Published
- 2023
- Full Text
- View/download PDF
18. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.
- Author
-
Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher RK, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dannlowski, Udo, Dale, Anders M, Davey, Christopher, de Geus, Eco JC, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Hahn, Tim, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J, Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, and Kalnin, Andrew
- Subjects
Karolinska Schizophrenia Project ,Amygdala ,Hippocampus ,Thalamus ,Corpus Striatum ,Humans ,Human Development ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Middle Aged ,Child ,Child ,Preschool ,Female ,Male ,Young Adult ,Neuroimaging ,ENIGMA ,brain morphometry ,longitudinal trajectories ,multisite ,Neurosciences ,Aging ,Aetiology ,2.1 Biological and endogenous factors ,Mental health ,Cognitive Sciences ,Experimental Psychology - Abstract
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
- Published
- 2022
19. Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years
- Author
-
Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven CR, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes‐Eizagirre, Anton, Alnæs, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur‐Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales‐Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim‐Avancini, Tiffany M, Ching, Christopher RK, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo‐Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Dannlowski, Udo, Davey, Christopher, Geus, Eco JC, Haan, Lieuwe, Zubicaray, Greig I, Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros‐Bergman, Helena, Fisher, Simon E, Fouche, Jean‐Paul, Franke, Barbara, Frodl, Thomas, Fuentes‐Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans‐Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Hahn, Tim, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J, Hibar, Derrek P, Hickie, Ian B, Ho, Beng‐Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Pol, Hilleke E Hulshoff, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, and Kahn, Rene
- Subjects
Behavioral and Social Science ,Neurosciences ,Aging ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Cerebral Cortex ,Child ,Child ,Preschool ,Cross-Sectional Studies ,Female ,Human Development ,Humans ,Male ,Middle Aged ,Neuroimaging ,Young Adult ,aging ,cortical thickness ,development ,trajectories ,Karolinska Schizophrenia Project ,Cognitive Sciences ,Experimental Psychology - Abstract
Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
- Published
- 2022
20. Immobilization of Horseradish Peroxidase onto Montmorillonite/Glucosamine–Chitosan Composite for Electrochemical Biosensing of Polyphenols
- Author
-
María Belén Piccoli, Florencia Alejandra Gulotta, Mariana Angélica Montenegro, Noelia Luciana Vanden Braber, Verónica Irene Paz Zanini, and Nancy Fabiana Ferreyra
- Subjects
water soluble chitosan derivatives ,glucosamine–chitosan ,sodium montmorillonite ,horseradish peroxidase ,polyphenols ,Biotechnology ,TP248.13-248.65 - Abstract
Glucosamine–chitosan synthesized by the Maillard reaction was combined with montmorillonite to obtain a nanohybrid composite to immobilize horseradish peroxidase. The material combines the advantageous properties of clay with those of the chitosan derivative; has improved water solubility and reduced molecular weight and viscosity; involves an eco-friendly synthesis; and exhibits ion exchange capacity, good adhesiveness, and a large specific surface area for enzyme adsorption. The physicochemical characteristics of the composite were analyzed by infrared spectroscopy and X-ray diffraction to determine clay–polycation interactions. The electrochemical response of the different polyphenols to glassy carbon electrodes modified with the composite was evaluated by cyclic voltammetry. The sensitivity and detection limit values obtained with the biosensor toward hydroquinone, chlorogenic acid, catechol, and resorcinol are (1.6 ± 0.2) × 102 µA mM−1 and (74 ± 8) nM; (1.2 ± 0.1) × 102 µA mM−1 and (26 ± 3) nM; (16 ± 2) µA mM−1 and (0.74 ± 0.09) μM; and (3.7± 0.3) µA mM−1 and (3.3 ± 0.2) μM, respectively. The biosensor was applied to quantify polyphenols in pennyroyal and lemon verbena extracts.
- Published
- 2024
- Full Text
- View/download PDF
21. Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group
- Author
-
Jia, Tianye, Chu, Congying, Liu, Yun, van Dongen, Jenny, Papastergios, Evangelos, Armstrong, Nicola J, Bastin, Mark E, Carrillo-Roa, Tania, den Braber, Anouk, Harris, Mathew, Jansen, Rick, Liu, Jingyu, Luciano, Michelle, Ori, Anil PS, Roiz Santiañez, Roberto, Ruggeri, Barbara, Sarkisyan, Daniil, Shin, Jean, Sungeun, Kim, Tordesillas Gutiérrez, Diana, van’t Ent, Dennis, Ames, David, Artiges, Eric, Bakalkin, Georgy, Banaschewski, Tobias, Bokde, Arun LW, Brodaty, Henry, Bromberg, Uli, Brouwer, Rachel, Büchel, Christian, Burke Quinlan, Erin, Cahn, Wiepke, de Zubicaray, Greig I, Ehrlich, Stefan, Ekström, Tomas J, Flor, Herta, Fröhner, Juliane H, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Hoare, Jacqueline, Ittermann, Bernd, Jahanshad, Neda, Jiang, Jiyang, Kwok, John B, Martin, Nicholas G, Martinot, Jean-Luc, Mather, Karen A, McMahon, Katie L, McRae, Allan F, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Sämann, Philipp G, Schofield, Peter R, Smolka, Michael N, Stein, Dan J, Strike, Lachlan T, Teeuw, Jalmar, Thalamuthu, Anbupalam, Trollor, Julian, Walter, Henrik, Wardlaw, Joanna M, Wen, Wei, Whelan, Robert, Apostolova, Liana G, Binder, Elisabeth B, Boomsma, Dorret I, Calhoun, Vince, Crespo-Facorro, Benedicto, Deary, Ian J, Hulshoff Pol, Hilleke, Ophoff, Roel A, Pausova, Zdenka, Sachdev, Perminder S, Saykin, Andrew, Wright, Margaret J, Thompson, Paul M, Schumann, Gunter, and Desrivières, Sylvane
- Subjects
Biological Psychology ,Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Psychology ,Mental Health ,Neurosciences ,Genetics ,Human Genome ,Diabetes ,Neurodegenerative ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Mental health ,CpG Islands ,DNA Methylation ,Epigenesis ,Genetic ,Epigenome ,Genome-Wide Association Study ,Humans ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)-three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions.
- Published
- 2021
22. Lexical Variation of an East Midlands Mining Community
- Author
-
Braber, Natalie, author and Braber, Natalie
- Published
- 2022
- Full Text
- View/download PDF
23. Investigating chromosomal instability in long-term survivors with glioblastoma and grade 4 astrocytoma
- Author
-
Jochem K. H. Spoor, May den Braber, Clemens M. F. Dirven, Adam Pennycuick, Jirina Bartkova, Jiri Bartek, Vera van Dis, Thierry P. P. van den Bosch, Sieger Leenstra, and Subramanian Venkatesan
- Subjects
high grade glioma ,glioblastoma multiforme ,astrocytoma ,chromosomal instability ,genome instability ,IDH ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundOnly a small group of patients with glioblastoma multiforme (GBM) survives more than 36 months, so-called long-term survivors. Recent studies have shown that chromosomal instability (CIN) plays a prognostic and predictive role among different cancer types. Here, we compared histological (chromosome missegregation) and bioinformatic metrics (CIN signatures) of CIN in tumors of GBM typical survivors (≤36 months overall survival), GBM long-term survivors and isocitrate dehydrogenase (IDH)-mutant grade 4 astrocytomas.MethodsTumor sections of all gliomas were examined for anaphases and chromosome missegregation. Further CIN signature activity analysis in the The Cancer Genome Atlas (TCGA)-GBM cohort was performed.ResultsOur data show that chromosome missegregation is pervasive in high grade gliomas and is not different between the 3 groups. We find only limited evidence of altered CIN levels in tumors of GBM long-term survivors relative to the other groups, since a significant depletion in CIN signature 11 relative to GBM typical survivors was the only alteration detected. In contrast, within IDH-mutant grade 4 astrocytomas we detected a significant enrichment of CIN signature 5 and 10 activities and a depletion of CIN signature 1 activity relative to tumors of GBM typical survivors.ConclusionsOur data suggest that CIN is pervasive in high grade gliomas, however this is unlikely to be a major contributor to the phenomenon of long-term survivorship in GBM. Nevertheless, further evaluation of specific types of CIN (signatures) could have prognostic value in patients suffering from grade 4 gliomas.
- Published
- 2024
- Full Text
- View/download PDF
24. The immunological landscape of peripheral blood in glioblastoma patients and immunological consequences of age and dexamethasone treatment
- Author
-
Sophie A. Dusoswa, Jan Verhoeff, Saskia van Asten, Joyce Lübbers, Marlous van den Braber, Sophie Peters, Sanne Abeln, Matheus H.W. Crommentuijn, Pieter Wesseling, William Peter Vandertop, Jos W. R. Twisk, Thomas Würdinger, David Noske, Yvette van Kooyk, and Juan J. Garcia-Vallejo
- Subjects
glioblastoma ,mass cytometry ,immune monitoring ,dexamethasone ,large cohort ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundGlioblastomas manipulate the immune system both locally and systemically, yet, glioblastoma-associated changes in peripheral blood immune composition are poorly studied. Age and dexamethasone administration in glioblastoma patients have been hypothesized to limit the effectiveness of immunotherapy, but their effects remain unclear. We compared peripheral blood immune composition in patients with different types of brain tumor to determine the influence of age, dexamethasone treatment, and tumor volume.MethodsHigh-dimensional mass cytometry was used to characterise peripheral blood mononuclear cells of 169 patients with glioblastoma, lower grade astrocytoma, metastases and meningioma. We used blood from medically-refractory epilepsy patients and healthy controls as control groups. Immune phenotyping was performed using FlowSOM and t-SNE analysis in R followed by supervised annotation of the resulting clusters. We conducted multiple linear regression analysis between intracranial pathology and cell type abundance, corrected for clinical variables. We tested correlations between cell type abundance and survival with Cox-regression analyses.ResultsGlioblastoma patients had significantly fewer naive CD4+ T cells, but higher percentages of mature NK cells than controls. Decreases of naive CD8+ T cells and alternative monocytes and an increase of memory B cells in glioblastoma patients were influenced by age and dexamethasone treatment, and only memory B cells by tumor volume. Progression free survival was associated with percentages of CD4+ regulatory T cells and double negative T cells.ConclusionHigh-dimensional mass cytometry of peripheral blood in patients with different types of intracranial tumor provides insight into the relation between intracranial pathology and peripheral immune status. Wide immunosuppression associated with age and pre-operative dexamethasone treatment provide further evidence for their deleterious effects on treatment with immunotherapy.
- Published
- 2024
- Full Text
- View/download PDF
25. High-dimensional phenotyping of the peripheral immune response in community-acquired pneumonia
- Author
-
Tom D. Y. Reijnders, Alex R. Schuurman, Jan Verhoeff, Marlous van den Braber, Renée A. Douma, Daniël R. Faber, Alberta G. A. Paul, W. Joost Wiersinga, Anno Saris, Juan J. Garcia Vallejo, and Tom van der Poll
- Subjects
pneumonia ,immunophenotyping ,host response ,COVID-19 ,spectral flow cytometry ,monocytes ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundCommunity-acquired pneumonia (CAP) represents a major health burden worldwide. Dysregulation of the immune response plays an important role in adverse outcomes in patients with CAP.MethodsWe analyzed peripheral blood mononuclear cells by 36-color spectral flow cytometry in adult patients hospitalized for CAP (n=40), matched control subjects (n=31), and patients hospitalized for COVID-19 (n=35).ResultsWe identified 86 immune cell metaclusters, 19 of which (22.1%) were differentially abundant in patients with CAP versus matched controls. The most notable differences involved classical monocyte metaclusters, which were more abundant in CAP and displayed phenotypic alterations reminiscent of immunosuppression, increased susceptibility to apoptosis, and enhanced expression of chemokine receptors. Expression profiles on classical monocytes, driven by CCR7 and CXCR5, divided patients with CAP into two clusters with a distinct inflammatory response and disease course. The peripheral immune response in patients with CAP was highly similar to that in patients with COVID-19, but increased CCR7 expression on classical monocytes was only present in CAP.ConclusionCAP is associated with profound cellular changes in blood that mainly relate to classical monocytes and largely overlap with the immune response detected in COVID-19.
- Published
- 2023
- Full Text
- View/download PDF
26. Chitosan-glucose derivative as effective wall material for probiotic yeasts microencapsulation
- Author
-
Díaz Vergara, Ladislao I., Arata Badano, Joaquín, Aminahuel, Carla A., Vanden Braber, Noelia L., Rossi, Yanina E., Pereyra, Carina M., Cavaglieri, Lilia R., and Montenegro, Mariana A.
- Published
- 2023
- Full Text
- View/download PDF
27. New technololgies for tissue replacement: Highlighting technologies for surgical management of chronic wounds
- Author
-
Piaggesi, Alberto, Bassetto, Franco, den Braber, Edwin, Dalla Paola, Luca, Marques, Alexandra, Palla, Ilaria, Raspovic, Katherine, Scarpa, Carlotta, Teot, Luc, Triulzi, Isotta, Turchetti, Giuseppe, and Becquemin, Jean-Pierre
- Published
- 2023
28. Chapter 7. How could hybrid true potato seed foster development in potato sectors in East Africa?
- Author
-
den Braber, H., primary, de Vries, M.E., additional, Kacheyo, O.C., additional, Struik, P.C., additional, and Descheemaeker, K., additional
- Published
- 2023
- Full Text
- View/download PDF
29. The heritability of vocal tract structures estimated from structural MRI in a large cohort of Dutch twins
- Author
-
Dediu, Dan, Jennings, Emily M., van’t Ent, Dennis, Moisik, Scott R., Di Pisa, Grazia, Schulze, Janna, de Geus, Eco J. C., den Braber, Anouk, Dolan, Conor V., and Boomsma, Dorret I.
- Published
- 2022
- Full Text
- View/download PDF
30. Gut Microbiome and Transcriptomic Changes in Cigarette Smoke-Exposed Mice Compared to COPD and CD Patient Datasets
- Author
-
Lei Wang, Pim J. Koelink, Johan Garssen, Gert Folkerts, Paul A. J. Henricks, and Saskia Braber
- Subjects
COPD ,cigarette smoke ,gut–lung axis ,IBD ,gut microbiome ,transcriptome ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Chronic obstructive pulmonary disease (COPD) patients and smokers have a higher incidence of intestinal disorders. The aim of this study was to gain insight into the transcriptomic changes in the lungs and intestines, and the fecal microbial composition after cigarette smoke exposure. Mice were exposed to cigarette smoke and their lung and ileum tissues were analyzed by RNA sequencing. The top 15 differentially expressed genes were investigated in publicly available gene expression datasets of COPD and Crohn’s disease (CD) patients. The murine microbiota composition was determined by 16S rRNA sequencing. Increased expression of MMP12, GPNMB, CTSK, CD68, SPP1, CCL22, and ITGAX was found in the lungs of cigarette smoke-exposed mice and COPD patients. Changes in the intestinal expression of CD79B, PAX5, and FCRLA were observed in the ileum of cigarette smoke-exposed mice and CD patients. Furthermore, inflammatory cytokine profiles and adhesion molecules in both the lungs and intestines of cigarette smoke-exposed mice were profoundly changed. An altered intestinal microbiota composition and a reduction in bacterial diversity was observed in cigarette smoke-exposed mice. Altered gene expression in the murine lung was detected after cigarette smoke exposure, which might simulate COPD-like alterations. The transcriptomic changes in the intestine of cigarette smoke-exposed mice had some similarities with those of CD patients and were associated with changes in the intestinal microbiome. Future research could benefit from investigating the specific mechanisms underlying the observed gene expression changes due to cigarette smoke exposure, focusing on identifying potential therapeutic targets for COPD and CD.
- Published
- 2024
- Full Text
- View/download PDF
31. The genetic architecture of the human cerebral cortex
- Author
-
Grasby, Katrina L, Jahanshad, Neda, Painter, Jodie N, Colodro-Conde, Lucía, Bralten, Janita, Hibar, Derrek P, Lind, Penelope A, Pizzagalli, Fabrizio, Ching, Christopher RK, McMahon, Mary Agnes B, Shatokhina, Natalia, Zsembik, Leo CP, Thomopoulos, Sophia I, Zhu, Alyssa H, Strike, Lachlan T, Agartz, Ingrid, Alhusaini, Saud, Almeida, Marcio AA, Alnæs, Dag, Amlien, Inge K, Andersson, Micael, Ard, Tyler, Armstrong, Nicola J, Ashley-Koch, Allison, Atkins, Joshua R, Bernard, Manon, Brouwer, Rachel M, Buimer, Elizabeth EL, Bülow, Robin, Bürger, Christian, Cannon, Dara M, Chakravarty, Mallar, Chen, Qiang, Cheung, Joshua W, Couvy-Duchesne, Baptiste, Dale, Anders M, Dalvie, Shareefa, de Araujo, Tânia K, de Zubicaray, Greig I, de Zwarte, Sonja MC, Braber, Anouk den, Doan, Nhat Trung, Dohm, Katharina, Ehrlich, Stefan, Engelbrecht, Hannah-Ruth, Erk, Susanne, Fan, Chun Chieh, Fedko, Iryna O, Foley, Sonya F, Ford, Judith M, Fukunaga, Masaki, Garrett, Melanie E, Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L, Green, Melissa J, Groenewold, Nynke A, Grotegerd, Dominik, Gurholt, Tiril P, Gutman, Boris A, Hansell, Narelle K, Harris, Mathew A, Harrison, Marc B, Haswell, Courtney C, Hauser, Michael, Herms, Stefan, Heslenfeld, Dirk J, Ho, New Fei, Hoehn, David, Hoffmann, Per, Holleran, Laurena, Hoogman, Martine, Hottenga, Jouke-Jan, Ikeda, Masashi, Janowitz, Deborah, Jansen, Iris E, Jia, Tianye, Jockwitz, Christiane, Kanai, Ryota, Karama, Sherif, Kasperaviciute, Dalia, Kaufmann, Tobias, Kelly, Sinead, Kikuchi, Masataka, Klein, Marieke, Knapp, Michael, Knodt, Annchen R, Krämer, Bernd, Lam, Max, Lancaster, Thomas M, Lee, Phil H, Lett, Tristram A, Lewis, Lindsay B, Lopes-Cendes, Iscia, Luciano, Michelle, Macciardi, Fabio, Marquand, Andre F, Mathias, Samuel R, Melzer, Tracy R, and Milaneschi, Yuri
- Subjects
Biological Sciences ,Genetics ,Neurosciences ,Mental Health ,Brain Disorders ,Stem Cell Research ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Attention Deficit Disorder with Hyperactivity ,Brain Mapping ,Cerebral Cortex ,Cognition ,Genetic Loci ,Genetic Variation ,Genome-Wide Association Study ,Humans ,Magnetic Resonance Imaging ,Organ Size ,Parkinson Disease ,Alzheimer’s Disease Neuroimaging Initiative ,CHARGE Consortium ,EPIGEN Consortium ,IMAGEN Consortium ,SYS Consortium ,Parkinson’s Progression Markers Initiative ,Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group ,General Science & Technology - Abstract
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
- Published
- 2020
32. Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
- Author
-
Sønderby, Ida E, Gústafsson, Ómar, Doan, Nhat Trung, Hibar, Derrek P, Martin-Brevet, Sandra, Abdellaoui, Abdel, Ames, David, Amunts, Katrin, Andersson, Michael, Armstrong, Nicola J, Bernard, Manon, Blackburn, Nicholas, Blangero, John, Boomsma, Dorret I, Bralten, Janita, Brattbak, Hans-Richard, Brodaty, Henry, Brouwer, Rachel M, Bülow, Robin, Calhoun, Vince, Caspers, Svenja, Cavalleri, Gianpiero, Chen, Chi-Hua, Cichon, Sven, Ciufolini, Simone, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Dale, Anders M, Dalvie, Shareefa, Dazzan, Paola, de Geus, Eco JC, de Zubicaray, Greig I, de Zwarte, Sonja MC, Delanty, Norman, den Braber, Anouk, Desrivières, Sylvane, Donohoe, Gary, Draganski, Bogdan, Ehrlich, Stefan, Espeseth, Thomas, Fisher, Simon E, Franke, Barbara, Frouin, Vincent, Fukunaga, Masaki, Gareau, Thomas, Glahn, David C, Grabe, Hans, Groenewold, Nynke A, Haavik, Jan, Håberg, Asta, Hashimoto, Ryota, Hehir-Kwa, Jayne Y, Heinz, Andreas, Hillegers, Manon HJ, Hoffmann, Per, Holleran, Laurena, Hottenga, Jouke-Jan, Hulshoff, Hilleke E, Ikeda, Masashi, Jahanshad, Neda, Jernigan, Terry, Jockwitz, Christiane, Johansson, Stefan, Jonsdottir, Gudrun A, Jönsson, Erik G, Kahn, Rene, Kaufmann, Tobias, Kelly, Sinead, Kikuchi, Masataka, Knowles, Emma EM, Kolskår, Knut K, Kwok, John B, Hellard, Stephanie Le, Leu, Costin, Liu, Jingyu, Lundervold, Astri J, Lundervold, Arvid, Martin, Nicholas G, Mather, Karen, Mathias, Samuel R, McCormack, Mark, McMahon, Katie L, McRae, Allan, Milaneschi, Yuri, Moreau, Clara, Morris, Derek, Mothersill, David, Mühleisen, Thomas W, Murray, Robin, Nordvik, Jan E, Nyberg, Lars, Olde Loohuis, Loes M, Ophoff, Roel, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda, Peralta, Juan M, Pike, Bruce, and Prieto, Carlos
- Subjects
Intellectual and Developmental Disabilities (IDD) ,Neurosciences ,Brain Disorders ,Autism ,Biomedical Imaging ,Mental Health ,Mental health ,Adult ,Autism Spectrum Disorder ,Autistic Disorder ,Basal Ganglia ,Brain ,Chromosome Deletion ,Chromosome Disorders ,Chromosome Duplication ,Chromosomes ,Human ,Pair 16 ,DNA Copy Number Variations ,Databases ,Factual ,Female ,Globus Pallidus ,Humans ,Image Processing ,Computer-Assisted ,Intellectual Disability ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Neurodevelopmental Disorders ,Organ Size ,Putamen ,Schizophrenia ,16p11.2 European Consortium ,for the ENIGMA-CNV working group ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry - Abstract
Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = -0.71 to -1.37; P
- Published
- 2020
33. Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia.
- Author
-
Sønderby, Ida E, Gústafsson, Ómar, Doan, Nhat Trung, Hibar, Derrek P, Martin-Brevet, Sandra, Abdellaoui, Abdel, Ames, David, Amunts, Katrin, Andersson, Michael, Armstrong, Nicola J, Bernard, Manon, Blackburn, Nicholas, Blangero, John, Boomsma, Dorret I, Bralten, Janita, Brattbak, Hans-Richard, Brodaty, Henry, Brouwer, Rachel M, Bülow, Robin, Calhoun, Vince, Caspers, Svenja, Cavalleri, Gianpiero, Chen, Chi-Hua, Cichon, Sven, Ciufolini, Simone, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Dale, Anders M, Dalvie, Shareefa, Dazzan, Paola, de Geus, Eco JC, de Zubicaray, Greig I, de Zwarte, Sonja MC, Delanty, Norman, den Braber, Anouk, Desrivières, Sylvane, Donohoe, Gary, Draganski, Bogdan, Ehrlich, Stefan, Espeseth, Thomas, Fisher, Simon E, Franke, Barbara, Frouin, Vincent, Fukunaga, Masaki, Gareau, Thomas, Glahn, David C, Grabe, Hans, Groenewold, Nynke A, Haavik, Jan, Håberg, Asta, Hashimoto, Ryota, Hehir-Kwa, Jayne Y, Heinz, Andreas, Hillegers, Manon HJ, Hoffmann, Per, Holleran, Laurena, Hottenga, Jouke-Jan, Hulshoff, Hilleke E, Ikeda, Masashi, Jahanshad, Neda, Jernigan, Terry, Jockwitz, Christiane, Johansson, Stefan, Jonsdottir, Gudrun A, Jönsson, Erik G, Kahn, Rene, Kaufmann, Tobias, Kelly, Sinead, Kikuchi, Masataka, Knowles, Emma EM, Kolskår, Knut K, Kwok, John B, Hellard, Stephanie Le, Leu, Costin, Liu, Jingyu, Lundervold, Astri J, Lundervold, Arvid, Martin, Nicholas G, Mather, Karen, Mathias, Samuel R, McCormack, Mark, McMahon, Katie L, McRae, Allan, Milaneschi, Yuri, Moreau, Clara, Morris, Derek, Mothersill, David, Mühleisen, Thomas W, Murray, Robin, Nordvik, Jan E, Nyberg, Lars, Olde Loohuis, Loes M, Ophoff, Roel, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda, Peralta, Juan M, Pike, Bruce, and Prieto, Carlos
- Subjects
16p11.2 European Consortium ,for the ENIGMA-CNV working group ,Neurosciences ,Psychiatry ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences - Abstract
Prior to and following the publication of this article the authors noted that the complete list of authors was not included in the main article and was only present in Supplementary Table 1. The author list in the original article has now been updated to include all authors, and Supplementary Table 1 has been removed. All other supplementary files have now been updated accordingly. Furthermore, in Table 1 of this Article, the replication cohort for the row Close relative in data set, n (%) was incorrect. All values have now been corrected to 0(0%). The publishers would like to apologise for this error and the inconvenience it may have caused.
- Published
- 2020
34. Genetic architecture of subcortical brain structures in 38,851 individuals
- Author
-
Satizabal, Claudia L, Adams, Hieab HH, Hibar, Derrek P, White, Charles C, Knol, Maria J, Stein, Jason L, Scholz, Markus, Sargurupremraj, Muralidharan, Jahanshad, Neda, Roshchupkin, Gennady V, Smith, Albert V, Bis, Joshua C, Jian, Xueqiu, Luciano, Michelle, Hofer, Edith, Teumer, Alexander, van der Lee, Sven J, Yang, Jingyun, Yanek, Lisa R, Lee, Tom V, Li, Shuo, Hu, Yanhui, Koh, Jia Yu, Eicher, John D, Desrivières, Sylvane, Arias-Vasquez, Alejandro, Chauhan, Ganesh, Athanasiu, Lavinia, Rentería, Miguel E, Kim, Sungeun, Hoehn, David, Armstrong, Nicola J, Chen, Qiang, Holmes, Avram J, den Braber, Anouk, Kloszewska, Iwona, Andersson, Micael, Espeseth, Thomas, Grimm, Oliver, Abramovic, Lucija, Alhusaini, Saud, Milaneschi, Yuri, Papmeyer, Martina, Axelsson, Tomas, Ehrlich, Stefan, Roiz-Santiañez, Roberto, Kraemer, Bernd, Håberg, Asta K, Jones, Hannah J, Pike, G Bruce, Stein, Dan J, Stevens, Allison, Bralten, Janita, Vernooij, Meike W, Harris, Tamara B, Filippi, Irina, Witte, A Veronica, Guadalupe, Tulio, Wittfeld, Katharina, Mosley, Thomas H, Becker, James T, Doan, Nhat Trung, Hagenaars, Saskia P, Saba, Yasaman, Cuellar-Partida, Gabriel, Amin, Najaf, Hilal, Saima, Nho, Kwangsik, Mirza-Schreiber, Nazanin, Arfanakis, Konstantinos, Becker, Diane M, Ames, David, Goldman, Aaron L, Lee, Phil H, Boomsma, Dorret I, Lovestone, Simon, Giddaluru, Sudheer, Le Hellard, Stephanie, Mattheisen, Manuel, Bohlken, Marc M, Kasperaviciute, Dalia, Schmaal, Lianne, Lawrie, Stephen M, Agartz, Ingrid, Walton, Esther, Tordesillas-Gutierrez, Diana, Davies, Gareth E, Shin, Jean, Ipser, Jonathan C, Vinke, Louis N, Hoogman, Martine, Jia, Tianye, Burkhardt, Ralph, Klein, Marieke, Crivello, Fabrice, Janowitz, Deborah, Carmichael, Owen, Haukvik, Unn K, Aribisala, Benjamin S, and Schmidt, Helena
- Subjects
Biological Sciences ,Genetics ,Neurosciences ,Biotechnology ,Mental Health ,Human Genome ,Brain Disorders ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Adult ,Aged ,Animals ,Brain ,Cohort Studies ,Drosophila melanogaster ,Genetic Variation ,Genome-Wide Association Study ,Humans ,Magnetic Resonance Imaging ,Middle Aged ,Neurodevelopmental Disorders ,Organ Size ,Medical and Health Sciences ,Developmental Biology ,Agricultural biotechnology ,Bioinformatics and computational biology - Abstract
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
- Published
- 2019
35. Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer’s disease polygenic risk score
- Author
-
Jori Tomassen, Anouk den Braber, Sven J. van der Lee, Lianne M. Reus, Elles Konijnenberg, Stephen F. Carter, Maqsood Yaqub, Bart N.M. van Berckel, Lyduine E. Collij, Dorret I. Boomsma, Eco J.C. de Geus, Philip Scheltens, Karl Herholz, Betty M. Tijms, and Pieter Jelle Visser
- Subjects
Preclinical Alzheimer’s disease ,APOE genotype ,Polygenic risk score ,Amyloid-β ,Cognitive decline ,Neuropsychology ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background: What combination of risk factors for Alzheimer’s disease (AD) are most predictive of cognitive decline in cognitively unimpaired individuals remains largely unclear. We studied associations between APOE genotype, AD-Polygenic Risk Scores (AD-PRS), amyloid-β pathology and decline in cognitive functioning over time in a large sample of cognitively unimpaired older individuals. Methods: We included 276 cognitively unimpaired older individuals (75 ± 10 years, 63% female) from the EMIF-AD PreclinAD cohort. An AD-PRS was calculated including 83 genome-wide significant variants. The APOE gene was not included in the PRS and was analyzed separately. Baseline amyloid-β status was assessed by visual read of [18F]flutemetamol-PET standardized uptake value images. At baseline and follow-up (2.0 ± 0.4 years), the cognitive domains of memory, attention, executive function, and language were measured. We used generalized estimating equations corrected for age, sex and center to examine associations between APOE genotype and AD-PRS with amyloid-β status. Linear mixed models corrected for age, sex, center and education were used to examine associations between APOE genotype, AD-PRS and amyloid-β status, and their interaction on changes in cognitive functioning over time. Results: Fifty-two participants (19%) had abnormal amyloid-β, and 84 participants (31%) carried at least one APOE ε4 allele. APOE genotype and AD-PRS were both associated with abnormal amyloid-β status. Increasingly more risk-full APOE genotype, a high AD-PRS and an abnormal amyloid-β status were associated with steeper decline in memory functioning in separate models (all p ≤ 0.02). A model including 4-way interaction term (APOE×AD-PRS×amyloid-β×time) was not significant. When modelled together, both APOE genotype and AD-PRS predicted steeper decline in memory functioning (APOE β(SE)=-0.05(0.02); AD-PRS β(SE)=-0.04(0.01)). Additionally, when modelled together, both amyloid-β status and AD-PRS predicted a steeper decline in memory functioning (amyloid-β β(SE)=-0.07(0.04); AD-PRS β(SE)=-0.04(0.01)). Modelling both APOE genotype and amyloid-β status, we observed an interaction, in which APOE genotype was related to steeper decline in memory and language functioning in amyloid-β abnormal individuals only (β(SE)=-0.13(0.06); β(SE)=-0.22(0.07), respectively). Conclusion: Our results suggest that APOE genotype is related to steeper decline in memory and language functioning in individuals with abnormal amyloid-β only. Furthermore, independent of amyloid-β status other genetic risk variants contribute to memory decline in initially cognitively unimpaired older individuals.
- Published
- 2022
- Full Text
- View/download PDF
36. Community projects
- Author
-
Braber, Natalie, primary
- Published
- 2023
- Full Text
- View/download PDF
37. Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population
- Author
-
Padrela, Beatriz E, Lorenzini, Luigi, Collij, Lyduine E, García, David Vállez, Coomans, Emma, Ingala, Silvia, Tomassen, Jori, Deckers, Quinten, Shekari, Mahnaz, Geus, Eco JC de, van de Giessen, Elsmarieke, Kate, Mara ten, Visser, Pieter Jelle, Barkhof, Frederik, Petr, Jan, Braber, Anouk den, and Mutsaerts, Henk JMM
- Published
- 2023
- Full Text
- View/download PDF
38. Manure matters: prospects for regional banana-livestock integration for sustainable intensification in South-West Uganda
- Author
-
Harmen den Braber, Gerrie van de Ven, Esther Ronner, Wytze Marinus, Antoine Languillaume, Dennis Ochola, Godfrey Taulya, Ken E. Giller, and Katrien Descheemaeker
- Subjects
east african highland banana ,crop-livestock integration ,potassium ,spatial analysis ,nutrient requirements ,cattle ,Agriculture - Abstract
In South-West Uganda, manure is highly valued for sustaining yields of East African Highland Banana, but it is in short supply. As a result, banana growers import manure from rangelands up to 50 km away. We aimed to explore the potential of this regional banana-livestock integration to meet crop nutrient requirements for sustainable intensification of banana cropping systems. We used a mixed-methods approach supported by detailed data collection. Multiple spatial levels were integrated: field-level modelling to determine long-term nutrient requirements, a household-level survey to characterize farmer practices, and a regional-level spatial analysis to map banana production and manure source areas. For median to 90th percentile banana yields (37-52 t FW/ha/year), minimum K requirements were 118–228 kg/ha/year. To supply this with manure, 10.5–20.5 t DM manure/ha/year would be needed, requiring 47–91 tropical livestock units and 27–52 ha of rangeland, far more than what is potentially available currently. However, using only manure to satisfy potassium requirements increases the risk of N losses due to nutrient imbalances likely to result from large manure applications. For sustainable intensification, manure supplemented with K-based fertilizers is a better option than manure alone, as it is more cost-effective and reduces potential N losses.
- Published
- 2022
- Full Text
- View/download PDF
39. THE 1984–85 MINERS STRIKE IN NOTTINGHAMSHIRE : GONE BUT NOT FORGOTTEN
- Author
-
Braber, Natalie
- Published
- 2021
40. Approaches to the study of poverty and environmental impacts of conservation interventions
- Author
-
den Braber, Bowy, Evans, Karl, and Oldekop, Johan
- Subjects
333.72 - Abstract
Reducing poverty and halting biodiversity loss are two crucial global goals. Protected areas (PAs) are an important example of how goals to reduce poverty and halt biodiversity loss interact. PAs aim to conserve biodiversity, but also have impacts on poverty. In this thesis I focus on the environmental and social impacts of protected areas using a suite of large datasets. Specifically, I focus on how our understanding of PA impacts can be improved by (1) assessing heterogeneity in more detail, (2) comparing impacts relative to impacts of other land uses, and (3) by using better data to study impacts in countries with currently insufficient data. In chapter 2 I assess how Nepali PAs influence poverty, extreme poverty, and inequality. I find that Nepali PAs reduced overall poverty and extreme poverty, and crucially, did not exacerbate inequality. I also find that tourism was a key driver in poverty reductions, but PAs also reduced extreme poverty in areas with few tourists. In chapter 3 I compare PA impacts relative to competing land uses and find that sustainable use PAs, agriculture and mining have led to different outcomes in forest cover and poverty in the Brazilian Amazon. I also show that PAs were effective in reducing deforestation compared to larger-sized landholdings, but not smallholders. I also show evidence that mining sites had more deforestation, but that mining sites also raised local income. In chapter 4 I test whether machine learning methods can be informative to estimate poverty in Tanzania using publicly available satellite imagery. I find that our machine learning methods can be used to estimate household consumption fairly accurately, but cannot be used to measure poverty change or multidimensional poverty. Combined, my findings highlight that PAs can reduce poverty and protect forests although impacts are highly heterogeneous and further scrutiny of PA impacts is needed in more countries. Novel methods using publicly available secondary data show promise to drastically improve the evidence base of PA impacts in data-poor countries where poverty is most prevalent.
- Published
- 2019
41. Immobilization of Horseradish Peroxidase onto Montmorillonite/Glucosamine–Chitosan Composite for Electrochemical Biosensing of Polyphenols
- Author
-
Piccoli, María Belén, primary, Gulotta, Florencia Alejandra, additional, Montenegro, Mariana Angélica, additional, Vanden Braber, Noelia Luciana, additional, Paz Zanini, Verónica Irene, additional, and Ferreyra, Nancy Fabiana, additional
- Published
- 2024
- Full Text
- View/download PDF
42. Galacto-oligosaccharides alleviate lung inflammation by inhibiting NLRP3 inflammasome activation in vivo and in vitro
- Author
-
Yang Cai, Myrthe S. Gilbert, Walter J.J. Gerrits, Gert Folkerts, and Saskia Braber
- Subjects
Respiratory infections ,Mannheimia haemolytica ,IL-1β ,Non-digestible oligosaccharides ,Primary bronchial epithelial cells ,Reactive oxygen species ,Medicine (General) ,R5-920 ,Science (General) ,Q1-390 - Abstract
Introduction: The lack of effective anti-inflammatory therapies for pneumonia represents a challenge for identifying new alternatives. Non-digestible galacto-oligosaccharides (GOS) are attractive candidates due to their anti-inflammatory and immunomodulatory effects both locally and systemically. Objectives: The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549). To delineate the mechanism, the potential capacity of GOS to inhibit the NLR family pyrin domain containing 3 (NLRP3) inflammasome has been investigated. Methods: GOS were administrated orally to calves with naturally occurring lung infections during early life or used as pretreatments in cell cultures exposed to M. haemolytica, lipopolysaccharides (LPS), leukotoxin or ATP. The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo. Key markers of NLRP3 inflammasome activation were measured in vivo and in vitro. Results: GOS reduced M. haemolytica positivity and M. haemolytica-LPS lgG levels in calves with lung infections. Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves. The M. haemolytica-induced IL-1β production in PBECs was lowered by GOS, which was associated with NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production. GOS inhibited leukotoxin-induced ATP production in PBECs. The LPS- and ATP-induced NLRP3 inflammasome activation in PBECs and A549 cells was suppressed by GOS. Conclusion: GOS exert anti-inflammatory properties by inhibiting the NLRP3 inflammasome activation in vitro and in vivo, suggesting a potential role for GOS in the prevention of lung infections.
- Published
- 2022
- Full Text
- View/download PDF
43. Deoxynivalenol exposure during pregnancy has adverse effects on placental structure and immunity in mice model
- Author
-
Toutounchi, Negisa Seyed, Braber, Saskia, Land, Belinda van‘t, Thijssen, Suzan, Garssen, Johan, Folkerts, Gert, and Hogenkamp, Astrid
- Published
- 2022
- Full Text
- View/download PDF
44. Galacto-oligosaccharides alleviate lung inflammation by inhibiting NLRP3 inflammasome activation in vivo and in vitro
- Author
-
Cai, Yang, Gilbert, Myrthe S., Gerrits, Walter J.J., Folkerts, Gert, and Braber, Saskia
- Published
- 2022
- Full Text
- View/download PDF
45. Minthostachys verticillata Griseb (Epling.) (Lamiaceae) essential oil orally administered modulates gastrointestinal immunological and oxidative parameters in mice
- Author
-
Montironi, Ivana D., Campra, Noelia A., Arsaute, Sofía, Cecchini, María Eugenia, Raviolo, José M., Vanden Braber, Noelia, Barrios, Bibiana, Montenegro, Mariana, Correa, Silvia, Grosso, María C., Mañas, Fernando, Bellingeri, Romina V., and Cariddi, Laura Noelia
- Published
- 2022
- Full Text
- View/download PDF
46. Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer’s disease polygenic risk score
- Author
-
Tomassen, Jori, den Braber, Anouk, van der Lee, Sven J., Reus, Lianne M., Konijnenberg, Elles, Carter, Stephen F., Yaqub, Maqsood, van Berckel, Bart N.M., Collij, Lyduine E., Boomsma, Dorret I., de Geus, Eco J.C., Scheltens, Philip, Herholz, Karl, Tijms, Betty M., and Visser, Pieter Jelle
- Published
- 2022
- Full Text
- View/download PDF
47. Exercise Volume Versus Intensity and the Progression of Coronary Atherosclerosis in Middle-Aged and Older Athletes: Findings From the MARC-2 Study
- Author
-
Aengevaeren, Vincent L., Mosterd, Arend, Bakker, Esmée A., Braber, Thijs L., Nathoe, Hendrik M., Sharma, Sanjay, Thompson, Paul D., Velthuis, Birgitta K., and Eijsvogels, Thijs M.H.
- Published
- 2023
- Full Text
- View/download PDF
48. Galacto-oligosaccharides as an anti-bacterial and anti-invasive agent in lung infections
- Author
-
Cai, Yang, van Putten, Jos P.M., Gilbert, Myrthe S., Gerrits, Walter J.J., Folkerts, Gert, and Braber, Saskia
- Published
- 2022
- Full Text
- View/download PDF
49. Intratracheal administration of solutions in mice; development and validation of an optimized method with improved efficacy, reproducibility and accuracy
- Author
-
Pelgrim, Charlotte E., van Ark, Ingrid, Leusink-Muis, Thea, Brans, Maike A.D., Braber, Saskia, Garssen, Johan, van Helvoort, Ardy, Kraneveld, Aletta D., and Folkerts, Gert
- Published
- 2022
- Full Text
- View/download PDF
50. Development of thresholds and a visualization tool for use of a blood test in routine clinical dementia practice.
- Author
-
Verberk, Inge M. W., Jutte, Jolien, Kingma, Maurice Y., Vigneswaran, Sinthujah, Gouda, Mariam M. T. E. E., van Engelen, Marie‐Paule, Alcolea, Daniel, Arranz, Javier, Fortea, Juan, Lleó, Alberto, Chevalier, Claire, Marizzoni, Moira, van de Giessen, Elsmarieke M., Lemstra, Afina W., Pijnenburg, Yolande A. L., van der Flier, Wiesje M., den Braber, Anouk, Wilson, David, Schut, Martijn C., and van Harten, Argonde C.
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.