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4. Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description

Author

Bonnet, Clemence, Debillon, Louis, Al-Hashimi, Saba, Hoogewoud, Florence, Monnet, Dominique, Bourges, Jean-Louis, and Brézin, Antoine

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Clinical Research, Biomedical Imaging, Eye Disease and Disorders of Vision, Eye, Adult, Aged, Anterior Eye Segment, Anti-Bacterial Agents, Azithromycin, Corneal Stroma, Corneal Ulcer, Drug Therapy, Combination, Epithelium, Corneal, Female, Follow-Up Studies, Glucocorticoids, Humans, Immunosuppressive Agents, Male, Methylprednisolone, Middle Aged, Retrospective Studies, Slit Lamp Microscopy, Tomography, Optical Coherence, Peripheral ulcerative keratitis, Anterior segment optical coherence tomography, Cornea, Systemic vasculitis, Opthalmology and Optometry, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

BackgroundAnterior segment optical coherence tomography (AS OCT) is a helpful tool used to diagnose and manage many corneal conditions, but its use has not been reported in case of peripheral ulcerative keratitis (PUK). The aim of this study is to describe AS OCT findings in cases of PUK.MethodsRetrospective observational case series of six eyes presenting with a PUK and proven systemic vasculitis. Clinical course, slit lamp photographs, and AS OCT findings were the main outcomes.ResultsThe AS OCT findings were found to correlate with the ocular disease's level of activity. In the acute stage, an absence of corneal epithelium, a scrambled appearance of the anterior stroma and a heterogeneous stromal reflectivity were observed. During the reduction of disease level activity, an irregular hyporeflective epithelium, a smoother anterior stroma, and a homogenous hyperreflective stroma were seen. At the healed stage, a filling of the corneal defect by a hyporeflective thick epithelium, the persistence of the hyperreflective underlying stroma, and a demarcation line were observed. The mean total corneal thickness at last follow-up was significantly thicker (509 ± 147 μm) compared with the mean corneal thickness at onset (408 ± 131 μm; P = 0.03).ConclusionsAS OCT provides an assessment of structural changes occurring in PUK, useful for its diagnosis and monitoring.

Published
2020

7. Visual acuity and visual field as a function of disease duration in patients with birdshot chorioretinitis.

Author

Loeliger, Jordan, Monnet, Dominique, Thorne, Jennifer, Imikerene, Linda, Kecili, Souhila, and Brézin, Antoine P.

Abstract

Background Birdshot chorioretinitis (BSCR) is a chronic bilateral posterior uveitis, which can affect central as well as peripheral vision. The aim of this study was to assess how visual acuity and visual field evolved over time in patients with BSCR. Methods This was a prospective, observational, single-centre study based on data from the CO-BIRD cohort. Patient visits were categorised based on the time elapsed since the first symptoms, and groups of patients with different disease duration were defined. The main outcome measures were the best corrected visual acuity (BCVA), the mean deviation (MD) and the standard pattern deviation (PSD). Results The study included 447 Caucasian patients (181 males and 266 females), all of whom HLA-A29 carriers. From onset to 30 years of disease duration, the number of patients in each consecutive 5-year period was 237, 250, 196, 147, 78 and 32, respectively. Overall, the range of visual acuity and visual field results increased with disease duration. BCVA gradually decreased and showed a significant decline after 11-15 years after the first symptoms. Among the visual field indices, PSD significantly increased after 16-20 years, while MD showed a significant decline after 21-25 years. No major gender differences were found in visual outcomes, indicating comparable severity. The intereye correlations of MD and PSD were stronger than those of BCVA. Conclusions BSCR resulted in a large heterogeneity of visual outcomes, which increased with time. Our data provide an overview of the visual consequences of BSCR as a function of disease duration. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Endpoints for extraintestinal manifestations in inflammatory bowel disease trials: the EXTRA consensus from the International Organization for the Study of Inflammatory Bowel Diseases

Author

Guillo, Lucas, Abreu, Maria, Panaccione, Remo, Sandborn, William J, Azevedo, Valderilio F, Gensler, Lianne, Moghaddam, Bahar, Ahuja, Vineet, Ali, Sabrina A, Allez, Matthieu, Ananthakrishnan, Ashwin N, Bhattacharya, Abhik, Dubinsky, Marla, Griffiths, Anne, Hart, Ailsa, Korelitz, Burton, Kotze, Paulo G, Koutroubakis, Ioannis E, Lakatos, Peter L, Lindsay, James O, Magro, Fernando, Mantzaris, Gerassimos J, Ng, Siew C, O'Morain, Colm, Panés, Julian, Parigi, Tommaso, Ran, Zhihua, Rogler, Gerhard, Rubin, David T, Sachar, David B, Siegmund, Britta, Steinwurz, Flavio, Tysk, Curt, Vavricka, Stephan, Verstraete, Sofia G, Brezin, Antoine P, Haemel, Anna K, Dignass, Axel, Sands, Bruce E, Danese, Silvio, and Peyrin-Biroulet, Laurent

Published
2022
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9. Long-Term Safety and Efficacy of Adalimumab in Patients with Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis

Author

Suhler, Eric B., Jaffe, Glenn J., Fortin, Eric, Lim, Lyndell L., Merrill, Pauline T., Dick, Andrew D., Brezin, Antoine P., Nguyen, Quan Dong, Thorne, Jennifer E., Van Calster, Joachim, Cimino, Luca, Adan, Alfredo, Goto, Hiroshi, Kaburaki, Toshikatsu, Kramer, Michal, Vitale, Albert T., Kron, Martina, Song, Alexandra P., Liu, Jianzhong, Pathai, Sophia, Douglas, Kevin M., Schlaen, Ariel, Muccioli, Cristina, Van Velthoven, Mirjam E.J., Zierhut, Manfred, and Rosenbaum, James T.

Published
2021
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11. Birdshot Chorioretinitis in Patients Aged 80 and Older.

Author

Debillon, Louis, Thorne, Jennifer E., Bousquet, Elodie, Duraffour, Pierre, Kecili, Souhila, Monnet, Dominique, and Brézin, Antoine P.

Subjects
BIOFLUORESCENCE, IMMUNOSUPPRESSIVE agents, CHOROID, NEOVASCULARIZATION, UVEITIS
Abstract

Purpose: To assess the manifestations of birdshot chorioretinitis (BSCR) in patients aged 80 and over. Design: Among patients with BSCR followed in the CO-BIRD prospective cohort (ClinicalTrials.gov Identifier: NCT05153057), we analyzed the subgroup of patients aged 80 and over. Methods: Patients were assessed in a standardized manner. Confluent atrophy was defined as hypoautofluorescent spots on fundus autofluorescence (FAF). Results: We included 39 (8.8%) of the 442 enrolled CO-BIRD patients. The mean age was 83.8 ± 3.7 years. The mean logMAR BCVA was 0.52 ± 0.76, with 30 patients (76.9%) having 20/40 or better in at least one eye. Thirty-five (89.7%) patients were receiving no treatment. Confluent atrophy in the posterior pole, disrupted retrofoveal ellipsoid zone and choroidal neovascularization were associated with logMAR BCVA >0.3 (p <.0001). Conclusion: In patients aged 80 and over we observed a striking heterogeneity of outcomes, but most retained a BCVA that allowed them to drive. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Corticosteroids Decrease the Incidence and Activity of Choroidal Neovascularization in Patients with Punctuate Inner Choroidopathy or Multifocal Choroiditis.

Author

Vienne-Jumeau, Aliénor, Brézin, Antoine P., Seminel, Marie, Ribeaudeau-Saindelle, Florence, and Bousquet, Elodie

Subjects
*NEOVASCULARIZATION, *CORTICOSTEROIDS, *ODDS ratio, *LONGITUDINAL method
Abstract

To assess the effect of corticosteroids (CS) on choroidal neovascularization (CNV) occurrence and recurrence of activity over 2 years in patients with punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC). Retrospective longitudinal study. Previous use of CS was analyzed between group without CNV and group with CNV occurrence and recurrence. Thirty-six patients were included. Patients with CNV were less likely to have received CS in the 6 months following PIC or MFC diagnosis (17% versus 65%, p-value = 0.01). Patients with CNV who had a recurrence of neovascular activity were less likely to have received a previous CS therapy (20% versus 78%; odds ratio = 0.08, p-value = 0.005). This study suggests that patients with PIC and MFC should be treated by CS to prevent CNV development and decrease CNV recurrences. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Safety and Efficacy of Adalimumab in Patients with Noninfectious Uveitis in an Ongoing Open-Label Study: VISUAL III

Author

Suhler, Eric B., Adán, Alfredo, Brézin, Antoine P., Fortin, Eric, Goto, Hiroshi, Jaffe, Glenn J., Kaburaki, Toshikatsu, Kramer, Michal, Lim, Lyndell L., Muccioli, Cristina, Nguyen, Quan Dong, Van Calster, Joachim, Cimino, Luca, Kron, Martina, Song, Alexandra P., Liu, Jianzhong, Pathai, Sophia, Camez, Anne, Schlaen, Ariel, van Velthoven, Mirjam E.J., Vitale, Albert T., Zierhut, Manfred, Tari, Samir, and Dick, Andrew D.

Published
2018
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15. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative

Author

Accorinti, Massimo, Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Alsabaani, Nasser, Al-Shamarani, Mohamed, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Porto, Fernanda Belga Ottoni, Blanco, Ricardo, Yee, Anita Chan Sook, Chandran, Vinod, Chiquet, Christophe, Chng, Hiok Hee, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Cristobal, Couto, Cuevas, Miguel, Eurico da Fonseca, João, de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Merino, Claudia Eugenia Duran, Facsko, Andrea, Figueira, Luis, Fonollosa, Alejandro, Fortin, Eric, Gale, Richard, Galeazzi, Mauro, Garcia, Sandra, Garcia Ruiz de Morales, Jose Maria, Gašperšič, Nataša, Goldstein, Debra, Guedes, Marta, Guex-Crosier, Yan, Gul, Ahmet, Hamam, Rola, Haroon, Muhammad, Hasegawa, Kenichi, Heiligenhaus, Arnd, Hooper, Claire, Hwang, Yih-Shiou, Hwang, De-Kuang, Juanola, Xavier, Kaburaki, Toshikatsu, Kadayifcilar, Sibel, Kempen, John, Kezuka, Takeshi, Kherani, Amin, Kirsimäe, Maarja, Kotaniemi, Kaisu, Kraut, Aleksandra, Kubicka-Trząska, Agnieszka, Kuffova, Lucia, Lightman, Susan, Lim, Lyndell, Lim, Wee Kiak, McCluskey, Peter, McGuire, Mairide, Mirabelli, Pierfrancesco, Miserocchi, Elisabetta, Misiuk-Hojło, Marta, Muccioli, Cristina, Muñoz, Santiago, Murphy, Conor, Murray, Philip I., Nagy, Zoltan, Namba, Kenichi, Neri, Piergiorgio, Nguyen, Quan, O'Gradaigh, Donncha, Omair, Mohammed, Otsa, Kati, Ozyazgan, Yilmaz, Pablo, Franco, Paroli, Maria Pia, Pleyer, Uwe, Poór, Gyula, Proença, Rui, Rabinovitch, Theodore, Read, Russell, Rebrov, Margarita, Recillas-Gispert, Claudia, Rothova, Aniki, Schwartzman, Sergio, Seve, Pascal, Sharma, Srilakshmi, Sims, Joanne, Sohár, Nicolette, Suhler, Eric, Szántó, Sándor, Szepessy, Zsuzsanna, Tappeiner, Christoph, Thorne, Jennifer, Tugal Tutkun, Ilknur, Turno-Kręcicka, Anna, Van Calster, Joachim, van der Horst-Bruinsma, Irene, Vidovič Valentinčič, Nataša, Vitale, Albert, Voorduin Ramos, Stephanie, Vukojevic, Nenad, Wakefield, Denis, Willermain, François, Yalcindag, Nilufer, Yamamoto, Joyce Hisae, Yeh, Stephen, Zemaitiene, Reda, Ziouzina, Olga, Dick, Andrew D., Rosenbaum, James T., Al-Dhibi, Hassan A., Belfort, Rubens, Jr., Brézin, Antoine P., Chee, Soon Phaik, Davis, Janet L., Ramanan, Athimalaipet V., Sonoda, Koh-Hei, Carreño, Ester, Nascimento, Heloisa, Salah, Sawsen, Salek, Sherveen, Siak, Jay, and Steeples, Laura

Published
2018
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18. Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial

Author

Nguyen, Quan Dong, Merrill, Pauline T, Jaffe, Glenn J, Dick, Andrew D, Kurup, Shree Kumar, Sheppard, John, Schlaen, Ariel, Pavesio, Carlos, Cimino, Luca, Van Calster, Joachim, Camez, Anne A, Kwatra, Nisha V, Song, Alexandra P, Kron, Martina, Tari, Samir, and Brézin, Antoine P

Published
2016
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25. Bilateral Anterior Uveitis Following Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 – Case Report and Focused Review.

Author

Vienne-Jumeau, Aliénor, Brézin, Antoine P., and Debieb, Amina

Subjects
*MULTISYSTEM inflammatory syndrome in children, *IRIDOCYCLITIS, *SARS-CoV-2
Abstract

Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is a systemic hyperinflammatory state described in children recently infected with SARS-CoV-2. Ophthalmologically, non-purulent conjunctival injection is the most common symptom, but cases of uveitis have been described. Here, we present a case of bilateral granulomatous anterior uveitis in a 10-year-old boy, 12 days after diagnosis of PIMS-TS. Symptoms resolved after a week of topical treatment and there was no relapse after six months. We carried out a focus review on uveitis in children with PIMS-TS and found eight studies. All in all, 21 children were reported with a median age of 11.5 years. Most of them had bilateral anterior inflammation, without synechiae nor hypertonia, which lasted five to seven days and responded well to the use of corticoids. This symptom is a potential predictor of a more severe disease and this link should be further explored. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Clinical, biological, and ophthalmological characteristics differentiating arteritic from non-arteritic anterior ischaemic optic neuropathy

Author

Parreau, Simon, primary, Dentel, Alexandre, additional, Mhenni, Rania, additional, Dumonteil, Stéphanie, additional, Régent, Alexis, additional, Gondran, Guillaume, additional, Monnet, Dominique, additional, Brézin, Antoine P., additional, Ly, Kim-Heang, additional, Liozon, Éric, additional, Sené, Thomas, additional, and Terrier, Benjamin, additional

Published
2022
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29. Birdshot Chorioretinopathy: A Review

Author

Bousquet, Elodie, primary, Duraffour, Pierre, additional, Debillon, Louis, additional, Somisetty, Swathi, additional, Monnet, Dominique, additional, and Brézin, Antoine P., additional

Published
2022
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34. CMV-related anterior and intermediate uveitis in a kidney transplant recipient treated with belatacept

Author

Morel, Antoine, Debieb, Amina Chahrazed, Mrejen, David, Amrouche, Lucile, Scemla, Anne, Vilain, Estelle, Legendre, Christophe, Anglicheau, Dany, Zuber, Julien, Brézin, Antoine, and Chavarot, Nathalie

Abstract

Introduction Belatacept is associated with a higher incidence of cytomegalovirus (CMV) disease and atypical presentations. Ocular manifestations are rare, representing up to 5% of disease manifestations and previous cases consisted in isolated retinitis.Case Description Herein, we report the case of an 81-year-old kidney transplant recipient who developed an anterior and intermediate uveitis under belatacept therapy. The diagnosis was established using quantitative CMV polymerase chain reaction assays in the aqueous humor. Belatacept was interrupted and oral and topical valganciclovir treatments were instituted. Lesions however extended, leading to intensify the treatment by intra-venous and intra-vitreal ganciclovir injections. Visual acuity stabilized and ocular inflammation was finally controlled after 3 months.Conclusion Clinicians should be aware of CMV infection as a cause of anterior uveitis under belatacept-based regimen, even in the absence of symptoms suggestive of systemic CMV replication.

Published
2023
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39. The standardisation of uveitis nomenclature (SUN) project.

Author

Jabs, Douglas A., McCluskey, Peter, Palestine, Alan G., Thorne, Jennifer E., The Standardization of Uveitis Nomenclature Working Group, Accorinti, Massimo, Acharya, Nisha, Amer, Radgonde, Atmaca, Leyla S., Bar, Asaf, Barisani‐Asenbauer, Talin, Becker, Matthias D., Bélair, Marie‐Lyne, Belfort, Rubens, Bhatt, Nirali P., Biswas, Jyotirmay, Blodi, Barbara, Bodaghi, Bahram, Brézin, Antoine P., and Butler, Nicholas J.

Subjects
UVEITIS, EYE inflammation, MACHINE learning, TRANSLATIONAL research, IRIDOCYCLITIS
Abstract

The uveitides are a collection of over 30 diseases characterised by intraocular inflammation. Previous work demonstrated that the agreement among uveitis experts on diagnosis was modest at best with some pairs of experts having chance alone agreement on selected diseases. The Standardisation of Uveitis Nomenclature (SUN) is a17‐year collaboration among experts in uveitis, ocular image grading, informatics, and machine learning to improve clinical and translational uveitis research. The SUN "Developing Classification Criteria for the Uveitides" project used a rigorous, multi‐phase approach to develop classification criteria for 25 of the most common uveitic diseases. The project's phases were: (1) informatics; (2) case collection; (3) case selection; (4) machine learning; and (5) consensus review and publication. The results were classification criteria with a high degree of accuracy (93.3%–99.3% depending on anatomic class of the uveitis), the goal of which is to form the basis for future uveitis research. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Reply

Author

Dot, Corinne, Schweitzer, Cédric, Labbe, Antoine, Lignereux, François, Rozot, Pascal, Goguillot, Mélanie, Bugnard, Françoise, and Brezin, Antoine P.

Published
2023
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43. Impact on refractive surgery due to increasing use of personal protection equipment: Insights from EUROCOVCAT group

Author

Cummings, Arthur B, primary, Gildea, Cian, additional, Brézin, Antoine P, additional, Malyugin, Boris E, additional, Evren Kemer, Ozlem, additional, Kermani, Omid, additional, Prieto, Isabel, additional, Rejdak, Robert, additional, Teus, Miguel A, additional, Tognetto, Daniele, additional, Zweifel, Sandrine, additional, and Toro, Mario D, additional

Published
2021
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45. Impact on refractive surgery due to increasing use of personal protection equipment: Insights from EUROCOVCAT group

Author

Cummings, Arthur B, Gildea, Cian, Brézin, Antoine P; https://orcid.org/0000-0001-8461-3119, Malyugin, Boris E; https://orcid.org/0000-0001-5666-3493, Evren Kemer, Ozlem; https://orcid.org/0000-0001-9480-8470, Kermani, Omid, Prieto, Isabel, Rejdak, Robert, Teus, Miguel A; https://orcid.org/0000-0002-3835-9882, Tognetto, Daniele, Zweifel, Sandrine, Toro, Mario D; https://orcid.org/0000-0001-7152-2613, Cummings, Arthur B, Gildea, Cian, Brézin, Antoine P; https://orcid.org/0000-0001-8461-3119, Malyugin, Boris E; https://orcid.org/0000-0001-5666-3493, Evren Kemer, Ozlem; https://orcid.org/0000-0001-9480-8470, Kermani, Omid, Prieto, Isabel, Rejdak, Robert, Teus, Miguel A; https://orcid.org/0000-0002-3835-9882, Tognetto, Daniele, Zweifel, Sandrine, and Toro, Mario D; https://orcid.org/0000-0001-7152-2613

Abstract

Since the World Health Organization declared COVID-19 to be a pandemic on 11th March 2020, changes to social and sanitary practices have included significant issues in access and management of eye care during the COVID-19 pandemic. Additionally, the fear of loss, coupled with social distancing, lockdown, economic instability, and uncertainty, have led to a significant psychosocial impact that will have to be addressed. In the current COVID-19 pandemic, personal protective equipment such as face masks or face coverings have become a daily necessity. While "mass masking" along with hand hygiene and social distancing became more widespread, new issues began to emerge - particularly in those who wore spectacles as a means of vision correction. As we began to see routine patients again after the first lockdown had been lifted, many patients visited our clinics for refractive surgery consultations with a primary motivating factor of wanting spectacle independence due to the fogging of their spectacles as a result of wearing a mask. In this article, we report on new emerging issues in eye care due to the widespread use of masks and on the new unmet need in the corneal and cataract refractive surgery fields.

Published
2021

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