1. Health economic impact of first-pass success among patients with acute ischemic stroke treated with mechanical thrombectomy: a United States and European perspective.
- Author
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Zaidat, Osama, Ribo, Marc, Mattle, Heinrich, Saver, Jeffrey, Bozorgchami, Hormozd, Yoo, Albert, Ehm, Alexandra, Kottenmeier, Emilie, Cameron, Heather, Qadeer, Rana, and Andersson, Tommy
- Subjects
economics ,stroke ,thrombectomy ,Brain Ischemia ,Humans ,Ischemic Stroke ,Retrospective Studies ,Stents ,Stroke ,Thrombectomy ,Treatment Outcome ,United States - Abstract
BACKGROUND: First-pass effect (FPE), restoring complete or near complete reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 2c-3) in a single pass, is an independent predictor for good functional outcomes in the endovascular treatment of acute ischemic stroke. The economic implications of achieving FPE have not been assessed. OBJECTIVE: To assess the economic impact of achieving complete or near complete reperfusion after the first pass. METHODS: Post hoc analyses were conducted using ARISE II study data. The target population consisted of patients in whom mTICI 2c-3 was achieved, stratified into two groups: (1) mTICI 2c-3 achieved after the first pass (FPE group) or (2) after multiple passes (non-FPE group). Baseline characteristics, clinical outcomes, and healthcare resource use were compared between groups. Costs from peer-reviewed literature were applied to assess cost consequences from the perspectives of the United States (USA), France, Germany, Italy, Spain, Sweden, and United Kingdom (UK). RESULTS: Among patients who achieved mTICI 2c-3 (n=172), FPE was achieved in 53% (n=91). A higher proportion of patients in the FPE group reached good functional outcomes (90-day modified Rankin Scale score 0-2 80.46% vs 61.04%, p
- Published
- 2021