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5. A glomerular transcriptomic landscape of apolipoprotein L1 in Black patients with focal segmental glomerulosclerosis

Author

Dell, K., Sedor, J., Schachere, M., Negrey, J., Lemley, K., Silesky, B., Srivastava, T., Garrett, A., Sethna, C., Laurent, K., Canetta, P., Pradhan, A., Greenbaum, L., Wang, C., Kang, C., Adler, S., LaPage, J., Athavale, A., Itteera, M., Atkinson, M., Dell, T., Fervenza, F., Hogan, M., Lieske, J., Chernitskiy, V., Kaskel, F., Ross, M., Flynn, P., Kopp, J., Blake, J., Trachtman, H., Zhdanova, O., Modersitzki, F., Vento, S., Lafayette, R., Mehta, K., Gadegbeku, C., Quinn-Boyle, S., Hladunewich, M., Reich, H., Ling, P., Romano, M., Fornoni, A., Bidot, C., Kretzler, M., Gipson, D., Williams, A., Klida, C., Derebail, V., Gibson, K., Cole, E., Ormond-Foster, J., Holzman, L., Meyers, K., Kallem, K., Swenson, A., Sambandam, K., Wang, Z., Rogers, M., Jefferson, A., Hingorani, S., Tuttle, K., Bray, M., Pao, E., Cooper, A., Lin, J.J., Baker, Stefanie, Barisoni, L., Bixler, J., Desmond, H., Eddy, S., Fermin, D., Gillespie, B., Kurtz, V., Larkina, M., Li, S., Lienczewski, C.C., Liu, J., Mainieri, T., Mariani, L., Sampson, M., Smith, A., Zee, J., Avila-Casado, Carmen, Bagnasco, Serena, Gaut, Joseph, Hewitt, Stephen, Hodgin, Jeff, Lemley, Kevin, Mariani, Laura, Palmer, Matthew, Rosenberg, Avi, Royal, Virginie, Thomas, David, Zee, Jarcy, Barisoni, Laura, Nast, Cynthia, McNulty, Michelle T., Fermin, Damian, Eichinger, Felix, Jang, Dongkeun, Kretzler, Matthias, Burtt, Noël P., Pollak, Martin R., Flannick, Jason, Weins, Astrid, Friedman, David J., and Sampson, Matthew G.

Published
2022
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6. Pregnancy in Patients with the Fontan Operation

Author

Montanaro, C, primary, Boyle, S, additional, Wander, G, additional, Johnson, M R, additional, Roos-Hesselink, J W, additional, Patel, R, additional, Rafiq, I, additional, Silversides, C K, additional, and Gatzoulis, M A, additional

Published
2024
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7. Development and evaluation of deep learning–based segmentation of histologic structures in the kidney cortex with multiple histologic stains

Author

Sedor, J., Dell, K., Schachere, M., Negrey, J., Lemley, K., Lim, E., Srivastava, T., Garrett, A., Sethna, C., Laurent, K., Appel, G., Toledo, M., Barisoni, L., Greenbaum, L., Wang, C., Kang, C., Adler, S., Nast, C., LaPage, J., Stroger, John H., Jr., Athavale, A., Itteera, M., Neu, A., Boynton, S., Fervenza, F., Hogan, M., Lieske, J., Chernitskiy, V., Kaskel, F., Kumar, N., Flynn, P., Kopp, J., Blake, J., Trachtman, H., Zhdanova, O., Modersitzki, F., Vento, S., Lafayette, R., Mehta, K., Gadegbeku, C., Johnstone, D., Quinn-Boyle, S., Cattran, D., Hladunewich, M., Reich, H., Ling, P., Romano, M., Fornoni, A., Bidot, C., Kretzler, M., Gipson, D., Williams, A., LaVigne, J., Derebail, V., Gibson, K., Froment, A., Grubbs, S., Holzman, L., Meyers, K., Kallem, K., Lalli, J., Sambandam, K., Wang, Z., Rogers, M., Jefferson, A., Hingorani, S., Tuttle, K., Bray, M., Kelton, M., Cooper, A., Freedman, B., Lin, J.J., Jayapandian, Catherine P., Chen, Yijiang, Janowczyk, Andrew R., Palmer, Matthew B., Cassol, Clarissa A., Sekulic, Miroslav, Hodgin, Jeffrey B., Zee, Jarcy, Hewitt, Stephen M., O’Toole, John, Toro, Paula, Sedor, John R., Barisoni, Laura, and Madabhushi, Anant

Published
2021
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9. Coherent optical control of the spin of a single hole in a quantum dot

Author

Godden, T. M., Quilter, J. H., Ramsay, A. J., Wu, Yanwen, Brereton, P., Boyle, S. J., Luxmoore, I. J., Puebla-Nunez, J., Fox, A. M., and Skolnick, M. S.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We demonstrate coherent optical control of a single hole spin confined to an InAs/GaAs quantum dot. A superposition of hole spin states is created by fast (10-100 ps) dissociation of a spin-polarized electron-hole pair. Full control of the hole-spin is achieved by combining coherent rotations about two axes: Larmor precession of the hole-spin about an external Voigt geometry magnetic field, and rotation about the optical-axis due to the geometric phase shift induced by a picosecond laser pulse resonant with the hole-trion transition., Comment: 6 pages, 3 figs, include supplement, final version

Published
2011
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10. Effect of detuning on the phonon induced dephasing of optically driven InGaAs/GaAs quantum dots

Author

Ramsay, A. J., Godden, T. M., Boyle, S. J., Gauger, E. M., Nazir, A., Lovett, B. W., Gopal, Achanta Venu, Fox, A. M., and Skolnick, M. S.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Recently, longitudinal acoustic phonons have been identified as the main source of the intensity damping observed in Rabi rotation measurements of the ground-state exciton of a single InAs/GaAs quantum dot. Here we report experiments of intensity damped Rabi rotations in the case of detuned laser pulses, the results have implications for the coherent optical control of both excitons and spins using detuned laser pulses., Comment: 6 pages, 3 figs, invited conference paper ICPS 2010

Published
2011
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11. Fast high fidelity hole spin initialization in a single InGaAs quantum dot

Author

Godden, T. M., Boyle, S. J., Ramsay, A. J., Fox, A. M., and Skolnick, M. S.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Other Condensed Matter
Abstract

We demonstrate fast initialization of a single hole spin captured in an InGaAs quantum dot with a fidelity F>99% by applying a magnetic field parallel to the growth direction. We show that the fidelity of the hole spin, prepared by ionization of a photo-generated electron-hole pair, is limited by the precession of the exciton spin due to the anisotropic exchange interaction.

Published
2010
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12. Phonon induced Rabi frequency renormalization of optically driven single InGaAs/GaAs quantum dots

Author

Ramsay, A. J., Godden, T. M., Boyle, S. J., Gauger, E. M., Nazir, A., Lovett, B. W., Fox, A. M., and Skolnick, M. S.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Quantum Physics
Abstract

We study optically driven Rabi rotations of a quantum dot exciton transition between 5 and 50 K, and for pulse-areas of up to $14\pi$. In a high driving field regime, the decay of the Rabi rotations is nonmonotonic, and the period decreases with pulse-area and increases with temperature. By comparing the experiments to a weak-coupling model of the exciton-phonon interaction, we demonstrate that the observed renormalization of the Rabi frequency is induced by fluctuations in the bath of longitudinal acoustic phonons, an effect that is a phonon analogy of the Lamb-shift., Comment: 4-pages, 2 figs, final version published in PRL

Published
2010
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13. Towards coherent optical control of a single hole spin: Rabi rotation of a trion conditional on the spin state of the hole

Author

Ramsay, A. J., Boyle, S. J., Godden, T. M., Kolodka, R. S., Khatab, A. F. A., Oliveira, J. B. B., Skiba-Szymanska, J., Liuc, H. -Y., Hopkinson, M., Fox, A. M., and Skolnick, M. S.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

A hole spin is a potential solid-state q-bit, that may be more robust against nuclear spin induced dephasing than an electron spin. Here we propose and demonstrate the sequential preparation, control and detection of a single hole spin trapped on a self-assembled InGaAs/GaAs quantum dot. The dot is embedded in a photodiode structure under an applied electric-field. Fast, triggered, initialization of a hole spin is achieved by creating a spin-polarized electron-hole pair with a picosecond laser pulse, and in an applied electric-field, waiting for the electron to tunnel leaving a spin-polarized hole. Detection of the hole spin with picosecond time resolution is achieved a second picosecond laser pulse to probe the positive trion transition, where a trion is created conditional on the hole spin to be detected as a change in photocurrent. Finally, using this setup we observe a Rabi rotation of the hole-trion transition that is conditional on the hole spin, which for a pulse-area of $2\pi$ can be used to impart a phase-shift of $\pi$ between the hole spin states, a non-general manipulation of the hole spin., Comment: 24 pages 10 figs

Published
2009

14. Improved outcomes of large B‐cell lymphoma patients treated with CD19 CAR T in the UK over time.

Author

Boyle, S., Roddie, C., O'Reilly, M., Menne, T., Norman, J., Gibb, A., Lugthart, S., Chaganti, S., Gonzalez Arias, C., Jones, C., Latif, A., Uttenthal, B. J., Seymour, F., Osborne, W., Springell, D., Hardefeldt, P., Yallop, D., Thoulouli, E., Bloor, A., and Besley, C.

Subjects
*CD19 antigen, *CYTOKINE release syndrome, *BISPECIFIC antibodies, *DIFFUSE large B-cell lymphomas, *CHIMERIC antigen receptors, *INTENSIVE care units, *CUTANEOUS T-cell lymphoma
Abstract

Summary: The success of CD19 Chimeric antigen receptor (CAR) T‐cell therapy in large B‐cell lymphoma (LBCL) has been partially offset by toxicity and logistical challenges, which off‐the‐shelf agents like CD20xCD3 bispecific antibodies might potentially overcome. However, when using CAR T outcomes as the ʽstandard‐of‐care comparator̕ for relapsed/refractory (r/r) LBCL, a potential learning curve with implementing a novel, complex therapy like CAR T needs to be considered. To address this, we analysed 726 UK patients intended to be treated with CD19 CAR T for r/r LBCL and compared outcomes between the first year of the national CAR T programme (Era 1; 2019) and the more recent treatment era (Era 2; 2020–2022). We identified significant improvements for Era 2 versus Era 1 in dropout rate (17% vs. 27%, p = 0.001), progression‐free survival (1‐year PFS 50% vs. 32%, p < 0.001) and overall survival (1‐year OS 60% vs. 40%, p < 0.001). We also observed increased use of bridging therapy, improvement in bridging outcomes, more tocilizumab/corticosteroid use, reduced high‐grade cytokine release syndrome (4% vs. 9%, p = 0.01) and intensive care unit admissions (20% vs. 32%, p = 0.001). Our results demonstrate significant improvement in CAR T outcomes over time, highlighting the importance of using up‐to‐date clinical data when comparing CAR T against new treatment options for r/r LBCL. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Improved outcomes of large B‐cell lymphoma patients treated with CD19 CAR T in the UK over time

Author

Boyle, S., primary, Roddie, C., additional, O'Reilly, M., additional, Menne, T., additional, Norman, J., additional, Gibb, A., additional, Lugthart, S., additional, Chaganti, S., additional, Gonzalez Arias, C., additional, Jones, C., additional, Latif, A., additional, Uttenthal, B. J., additional, Seymour, F., additional, Osborne, W., additional, Springell, D., additional, Hardefeldt, P., additional, Yallop, D., additional, Thoulouli, E., additional, Bloor, A., additional, Besley, C., additional, Mathew, A., additional, Burns, D., additional, Cwynarski, K., additional, Sanderson, R., additional, and Kuhnl, A., additional

Published
2023
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16. Two qubit conditional quantum logic operation in a single self-assembled quantum dot

Author

Boyle, S. J., Ramsay, A. J., Bello, F., Liu, H. Y., Hopkinson, M., Fox, A. M., and Skolnick, M. S.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

The four-level exciton/biexciton system of a single semiconductor quantum dot acts as a two qubit register. We experimentally demonstrate an exciton-biexciton Rabi rotation conditional on the initial exciton spin in a single InGaAs/GaAs dot. This forms the basis of an optically gated two-qubit controlled-rotation (CROT) quantum logic operation where an arbitrary exciton spin is selected as the target qubit using the polarization of the control laser., Comment: 4- pages, 4 figures, to be submitted to PRL

Published
2008
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17. Fast optical preparation, control and read-out of single quantum dot spin

Author

Ramsay, A. J., Boyle, S. J., Kolodka, R. S., Oliveira, J. B. B., Skiba-Szymanska, J., Liu, H. Y., Hopkinson, M., Fox, A. M., and Skolnick, M. S.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We propose and demonstrate the sequential initialization, optical control, and read-out of a single spin trapped in a semiconductor quantum dot. Hole spin preparation is achieved through ionization of a resonantly excited electron-hole pair. Optical control is observed as a coherent Rabi rotation between the hole and charged exciton states, which is conditional on the initial hole spin state. The spin-selective creation of the charged exciton provides a photocurrent read-out of the hole spin state., Comment: 5 pages, 3 figures, resubmitted to PRL, changes due to referee comments

Published
2007
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21. Self‐reported gastrointestinal disorders among veterans with gulf war illness with and without posttraumatic stress disorder

Author

Malhotra, D., primary, Boyle, S. H., additional, Gifford, E. J., additional, Sullivan, B. A., additional, Nguyen Wenker, T. H., additional, ABS, Nono‐Djotsa, additional, Ahmed, S. T., additional, Upchurch, J., additional, Vahey, J., additional, Stafford, C., additional, Efird, J. T., additional, Hunt, S. C., additional, Bradford, A., additional, Sims, K. J., additional, Hauser, E. R., additional, Helmer, D. A., additional, and Williams, C. D., additional

Published
2023
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22. The efficacy and safety of systemic corticosteroids as first line treatment for granulomatous lymphocytic interstitial lung disease

Author

Smits, B., primary, Goldacker, S., additional, Seneviratne, S., additional, Malphettes, M., additional, Longhurst, H., additional, Mohamed, O.E., additional, Witt-Rautenberg, C., additional, Leeman, L., additional, Schwaneck, E., additional, Raymond, I., additional, Meghit, K., additional, Uhlmann, A., additional, Winterhalter, Ch., additional, van Montfrans, J., additional, Klima, M., additional, Workman, S., additional, Fieschi, C., additional, Lorenza, L., additional, Boyle, S., additional, Onyango-Odera, S., additional, Price, S., additional, Schmalzing, M., additional, Aurillac, V., additional, Prasse, A., additional, Hartmann, I., additional, Meerburg, J.J., additional, Kemner-van de Corput, M., additional, Tiddens, H., additional, Grimbacher, B., additional, Kelleher, P., additional, Patel, S.Y., additional, Korganow, A.-S., additional, Viallard, J.F., additional, Tony, H.P., additional, Bethune, C., additional, Schulze-Koops, H., additional, Witte, T., additional, Huissoon, A., additional, Baxendale, H., additional, Grigoriadou, S., additional, Oksenhendler, E., additional, Burns, S.O., additional, and Warnatz, K., additional

Published
2022
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24. The COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patients

Author

Tami, A., primary, van der Gun, B.T.F., additional, Wold, K.I., additional, Vincenti-González, M.F., additional, Veloo, A.C.M., additional, Knoester, M., additional, Harmsma, V.P.R., additional, de Boer, G.C., additional, Huckriede, A.L.W., additional, Pantano, D., additional, Gard, L., additional, Rodenhuis-Zybert, I., additional, Upasani, V., additional, Smit, J., additional, Dijkstra, A., additional, de Haan, J., additional, van Elst, J., additional, van den Boogaard, J., additional, O’ Boyle, S., additional, Nacul, L., additional, Niesters, H.G.M., additional, and Friedrich, A.W., additional

Published
2022
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25. Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

Author

Reijns M. A. M., Parry D. A., Williams T. C., Nadeu F., Hindshaw R. L., Rios Szwed D. O., Nicholson M. D., Carroll P., Boyle S., Royo R., Cornish A. J., Xiang H., Ridout K., Schuh A., Caravagna G, Aden K., Palles C., Campo E., Stankovic T., Taylor M. S., Jackson A. P., Barcelona Supercomputing Center, Reijns, M. A. M., Parry, D. A., Williams, T. C., Nadeu, F., Hindshaw, R. L., Rios Szwed, D. O., Nicholson, M. D., Carroll, P., Boyle, S., Royo, R., Cornish, A. J., Xiang, H., Ridout, K., Schuh, A., Caravagna, G, Aden, K., Palles, C., Campo, E., Stankovic, T., Taylor, M. S., and Jackson, A. P.

Subjects
Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], Genomic instability, cancer genomics, Eukaryotic cells, Nucleotide excision repair, Multidisciplinary, Cancer genomics, Genomes, Càncer--Aspectes genètics
Abstract

The mutational landscape is shaped by many processes. Genic regions are vulnerable to mutation but are preferentially protected by transcription-coupled repair1. In microorganisms, transcription has been demonstrated to be mutagenic2,3; however, the impact of transcription-associated mutagenesis remains to be established in higher eukaryotes4. Here we show that ID4—a cancer insertion–deletion (indel) mutation signature of unknown aetiology5 characterized by short (2 to 5 base pair) deletions —is due to a transcription-associated mutagenesis process. We demonstrate that defective ribonucleotide excision repair in mammals is associated with the ID4 signature, with mutations occurring at a TNT sequence motif, implicating topoisomerase 1 (TOP1) activity at sites of genome-embedded ribonucleotides as a mechanistic basis. Such TOP1-mediated deletions occur somatically in cancer, and the ID-TOP1 signature is also found in physiological settings, contributing to genic de novo indel mutations in the germline. Thus, although topoisomerases protect against genome instability by relieving topological stress6, their activity may also be an important source of mutations in the human genome. We thank S. Jinks-Robertson for suggesting the traffic light reporter approach; H. Klein for guidance on fluctuation assays; R. van Boxtel for sharing sequencing data for MLH1-KO organoids; A. Bretherick, O. B. Reina and G. Kudla for advice on HygroR re-coding; staff at the IGC core services (L. Murphy, C. Nicol, C. Warnock, E. Freyer, S. Brown and J. Joseph), C. Logan, A. Fluteau, A. Robertson and the staff at Edinburgh Genomics for technical assistance; staff at Liverpool CLL Biobank (funded by Blood Cancer UK) for samples used to generate GEL WGS data; A. Ewing, C.-A. Martin, N. Hastie and W. Bickmore for discussions. Funding for this work: UK Medical Research Council Human Genetics Unit core grants (MC_UU_00007/5 to A.P.J., MC_UU_00007/11 to M.S.T.); Edinburgh Clinical Academic Track PhD programme (Wellcome Trust 204802/Z/16/Z) to T.C.W.; 2021 AACR-Amgen Fellowship in Clinical/Translational Cancer Research (grant number 21-40-11-NADE) to F.N.; a CRUK Brain Tumour Centre of Excellence Award (C157/A27589) to M.D.N.; EKFS research grant (2019_A09), Wilhelm Sander-Stiftung (2019.046.1) to K.A., CRUK programme grant (C20807/A2864) to T.S.; La Caixa Foundation (CLLEvolution-LCF/PR/HR17/52150017, Health Research 2017 Program HR17-00221) to E.C.; E.C. is an Academia Researcher of the Institució Catalana de Recerca i Estudis Avançats of the Generalitat de Catalunya. Edinburgh Genomics is partly supported by NERC (R8/H10/56), MRC (MR/K001744/1) and BBSRC (BB/J004243/1). This research was made possible through access to the data and findings generated by the 100,000 Genomes Project. The 100,000 Genomes Project is managed by Genomics England Limited (a wholly owned company of the Department of Health and Social Care). The 100,000 Genomes Project is funded by the National Institute for Health Research and NHS England. The Wellcome Trust, Cancer Research UK and the Medical Research Council have also funded research infrastructure. The 100,000 Genomes Project uses data provided by patients and collected by the National Health Service as part of their care and support. Peer Reviewed "Article signat per 22 autors/es: Martin A. M. Reijns, David A. Parry, Thomas C. Williams, Ferran Nadeu, Rebecca L. Hindshaw, Diana O. Rios Szwed, Michael D. Nicholson, Paula Carroll, Shelagh Boyle, Romina Royo, Alex J. Cornish, Hang Xiang, Kate Ridout, The Genomics England Research Consortium, Colorectal Cancer Domain UK 100,000 Genomes Project, Anna Schuh, Konrad Aden, Claire Palles, Elias Campo, Tatjana Stankovic, Martin S. Taylor & Andrew P. Jackson "

Published
2022

27. A glomerular transcriptomic landscape of apolipoprotein L1 in Black patients with focal segmental glomerulosclerosis

Author

McNulty, Michelle T., primary, Fermin, Damian, additional, Eichinger, Felix, additional, Jang, Dongkeun, additional, Kretzler, Matthias, additional, Burtt, Noël P., additional, Pollak, Martin R., additional, Flannick, Jason, additional, Weins, Astrid, additional, Friedman, David J., additional, Sampson, Matthew G., additional, Dell, K., additional, Sedor, J., additional, Schachere, M., additional, Negrey, J., additional, Lemley, K., additional, Silesky, B., additional, Srivastava, T., additional, Garrett, A., additional, Sethna, C., additional, Laurent, K., additional, Canetta, P., additional, Pradhan, A., additional, Greenbaum, L., additional, Wang, C., additional, Kang, C., additional, Adler, S., additional, LaPage, J., additional, Athavale, A., additional, Itteera, M., additional, Atkinson, M., additional, Dell, T., additional, Fervenza, F., additional, Hogan, M., additional, Lieske, J., additional, Chernitskiy, V., additional, Kaskel, F., additional, Ross, M., additional, Flynn, P., additional, Kopp, J., additional, Blake, J., additional, Trachtman, H., additional, Zhdanova, O., additional, Modersitzki, F., additional, Vento, S., additional, Lafayette, R., additional, Mehta, K., additional, Gadegbeku, C., additional, Quinn-Boyle, S., additional, Hladunewich, M., additional, Reich, H., additional, Ling, P., additional, Romano, M., additional, Fornoni, A., additional, Bidot, C., additional, Kretzler, M., additional, Gipson, D., additional, Williams, A., additional, Klida, C., additional, Derebail, V., additional, Gibson, K., additional, Cole, E., additional, Ormond-Foster, J., additional, Holzman, L., additional, Meyers, K., additional, Kallem, K., additional, Swenson, A., additional, Sambandam, K., additional, Wang, Z., additional, Rogers, M., additional, Jefferson, A., additional, Hingorani, S., additional, Tuttle, K., additional, Bray, M., additional, Pao, E., additional, Cooper, A., additional, Lin, J.J., additional, Baker, Stefanie, additional, Barisoni, L., additional, Bixler, J., additional, Desmond, H., additional, Eddy, S., additional, Fermin, D., additional, Gillespie, B., additional, Kurtz, V., additional, Larkina, M., additional, Li, S., additional, Lienczewski, C.C., additional, Liu, J., additional, Mainieri, T., additional, Mariani, L., additional, Sampson, M., additional, Smith, A., additional, Zee, J., additional, Avila-Casado, Carmen, additional, Bagnasco, Serena, additional, Gaut, Joseph, additional, Hewitt, Stephen, additional, Hodgin, Jeff, additional, Lemley, Kevin, additional, Mariani, Laura, additional, Palmer, Matthew, additional, Rosenberg, Avi, additional, Royal, Virginie, additional, Thomas, David, additional, Zee, Jarcy, additional, Barisoni, Laura, additional, and Nast, Cynthia, additional

Published
2022
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31. Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome

Author

Hodgin, Jeffrey B., primary, Mariani, Laura H., additional, Zee, Jarcy, additional, Liu, Qian, additional, Smith, Abigail R., additional, Eddy, Sean, additional, Hartman, John, additional, Hamidi, Habib, additional, Gaut, Joseph P., additional, Palmer, Matthew B., additional, Nast, Cynthia C., additional, Chang, Anthony, additional, Hewitt, Stephen, additional, Gillespie, Brenda W., additional, Kretzler, Matthias, additional, Holzman, Lawrence B., additional, Barisoni, Laura, additional, Dell, K., additional, Sedor, J., additional, Schachere, M., additional, Negrey, J., additional, Lemley, K., additional, Lim, E., additional, Srivastava, T., additional, Garrett, A., additional, Sethna, C., additional, Laurent, K., additional, Canetta, P., additional, Pradhan, A., additional, Greenbaum, L., additional, Wang, C., additional, Kang, C., additional, Adler, S., additional, LaPage, J., additional, Athavale, A., additional, Itteera, M., additional, Atkinson, M., additional, Boynton, S., additional, Fervenza, F., additional, Hogan, M., additional, Lieske, J., additional, Chernitskiy, V., additional, Kaskel, F., additional, Ross, M., additional, Flynn, P., additional, Kopp, J., additional, Blake, J., additional, Trachtman, H., additional, Zhdanova, O., additional, Modersitzki, F., additional, Vento, S., additional, Bray, M., additional, Kelton, M., additional, Cooper, A., additional, Lafayette, R., additional, Mehta, K., additional, Gadegbeku, C., additional, Quinn-Boyle, S., additional, Hladunewich, M., additional, Reich, H., additional, Ling, P., additional, Romano, M., additional, Fornoni, A., additional, Bidot, C., additional, Kretzler, M., additional, Gipson, D., additional, Williams, A., additional, LaVigne, J., additional, Derebail, V., additional, Gibson, K., additional, Cole, E., additional, Ormond-Foster, J., additional, Holzman, L., additional, Meyers, K., additional, Kallem, K., additional, Swenson, A., additional, Sambandam, K., additional, Wang, Z., additional, Rogers, M., additional, Jefferson, A., additional, Hingorani, S., additional, Tuttle, K., additional, Lin, J.J., additional, Barisoni, L., additional, Bixler, J., additional, Desmond, H., additional, Eddy, S., additional, Fermin, D., additional, Gillespie, B., additional, Kurtz, V., additional, Larkina, M., additional, Lavigne, J., additional, Li, S., additional, Lienczewski, C.C., additional, Liu, J., additional, Mainieri, T., additional, Mariani, L., additional, Sampson, M., additional, Smith, A., additional, Zee, J., additional, Avila-Casado, Carmen, additional, Bagnasco, Serena, additional, Gaut, Joseph, additional, Hodgin, Jeff, additional, Lemley, Kevin, additional, Mariani, Laura, additional, Palmer, Matthew, additional, Rosenberg, Avi, additional, Royal, Virginie, additional, Thomas, David, additional, and Nast, Cynthia, additional

Published
2022
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35. Oro-Naso-Sino-Orbital-Cutaneous Fistula From Prolonged Cocaine Use

Author

Boyle S, Hussain M, Kirby C, Brennan S, Clarke L, Mullan R, Halpenny D, Conlon N, Mark Little, Bj, Conlon, and Abdulrahman S

Subjects
Male, Cocaine-Related Disorders, Cocaine, Cutaneous Fistula, Humans, Autoimmunity, Middle Aged
Abstract

Presentation We present the case of a 48-year-old man with nasal cellulitis and subsequent oro-naso-sino-orbital-cutaneous fistula from prolonged cocaine use. Diagnosis Initial laboratory investigations reported a raised white cell count (WBC) and C-Reactive Protein (CRP) and subsequently a positive atypical anti-neutrophil cytoplasm antibodies (ANCA) and positive anti-proteinase (PR3). Perihilar lung nodularity on chest imaging raised the possibility of a systemic autoimmune response. His urinalysis was positive for cocaine. Treatment He was commenced on Augmentin, Amphotericin B and Prednisolone. An obturator was created to manage the oro-nasal fistula. A subsequent naso-cutaneous defect was re-approximated. Daily nasal saline douche and abstinence of cocaine were recommended. Discussion Cocaine use in the community is rising and poses a challenge to multiple facets of our health care system.

Published
2022

41. The New Age of HBI

Author

Boehm, C., primary, Boyle, S., additional, Merki, A., additional, Millner, R., additional, Rothberger, J., additional, and Sterrer, W., additional

Published
2022
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48. Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis

Author

Zee, Jarcy, Liu, Qian, Smith, Abigail R., Hodgin, Jeffrey B., Rosenberg, Avi, Gillespie, Brenda W., Holzman, Lawrence B., Barisoni, Laura, Mariani, Laura H., Adler, S., Alter, G., Athavale, A., Atkinson, M., Avila-Casado, C., Bagnasco, S., Baker, S., Barisoni, L., Bidot, C., Blake, J., Bray, M., Canetta, P., Chernitskiy, V., Cooper, A., Dell, K., Dell, T., Derebail, V., Desmond, H., Eddy, S., Fermin, D., Fervenza, F., Flynn, P., Fornoni, A., Froment, A., Gadegbeku, C., Gaut, J., Gibson, K., Gillespie, B., Gipson, D., Greenbaum, L., Hewitt, S., Hingorani, S., Hladunewich, M., Hodgin, J., Hogan, M., Holzman, L., Itteera, M., Jefferson, A., Kallem, K., Kaskel, F., Klida, C., Kretzler, M., Kopp, J., Kretzler, M., Kurtz, V., Lafayette, R., LaPage, J., Larkina, M., Lemley, K., Lieske, J., Li, S., Li, S., Lienczewski, C.C., Lin, J.J., Ling, P., Liu, J., Mainieri, T., Mariani, L., Meyers, K., Modersitzki, F., Morrison, S., Nast, C., Negrey, J., Ormond-Foster, J., Palmer, M., Pao, E., Pfaiff, M., Pradhan, A., Romano, M., Rosenberg, A., Royal, V., Quinn-Boyle, S., Reich, H., Rogers, M., Ross, M., Sambandam, K., Sampson, M., Schachere, M., Sedor, J., Sethna, C., Srivastava, T., Smith, A., Swenson, A., Tang, S., Thomas, D., Trachtman, H., Tuttle, K., Vento, S., Wang, C., Wang, Z., Williams, A., Yeung, B., Yun, E., Zee, J., Zhdanova, O., Adler, S., Alter, G., Athavale, A., Atkinson, M., Avila-Casado, C., Bagnasco, S., Baker, S., Barisoni, L., Bidot, C., Blake, J., Bray, M., Canetta, P., Cassol, C., Chernitskiy, V., Cooper, A., Dell, K., Dell, T., Demeke, D., Derebail, V., Desmond, H., Eddy, S., Fermin, D., Fervenza, F., Flynn, P., Fornoni, A., Froment, A., Gadegbeku, C., Gaut, J., Gibson, K., Gillespie, B., Gipson, D., Greenbaum, L., Hewitt, S., Hingorani, S., Hladunewich, M., Hodgin, J., Hogan, M., Holanda, D., Holzman, L., Itteera, M., Jefferson, A., Kallem, K., Kaskel, F., Klida, C., Kopp, J., Kretzler, M., Kurtz, V., Lafayette, R., LaPage, J., Larkina, M., Lemley, K., Lieske, J., Li, S., Li, S., Lienczewski, C.C., Lin, J.J., Ling, P., Liu, J., Mainieri, T., Mariani, L., Messias, N., Meyers, K., Michailov, A., Modersitzki, F., Morrison, S., Nast, C., Negrey, J., Ormond-Foster, J., Palmer, M., Pao, E., Pfaiff, M., Pradhan, A., Romano, M., Rosenberg, A., Royal, V., Quinn-Boyle, S., Reich, H., Rogers, M., Ross, M., Sambandam, K., Sampson, M., Schachere, M., Sedor, J., Sethna, C., Srivastava, T., Smith, A., Swenson, A., Tang, S., Thomas, D., Trachtman, H., Tuttle, K., Vento, S., Wang, C., Wang, Z., Williams, A., Yamashita, M., Yeung, B., Yun, E., Zee, J., Zhdanova, O., and Zuo, Y.

Abstract

The classification of podocytopathies, including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), has historically been based on limited glomerular features. This study used supervised machine learning methods to identify the most important clinical and histopathologic predictors of disease progression, complete proteinuria remission, and treatment response in MCD/FSGS. The top predictors included conventional and novel glomerular and tubulointerstitial features. Biopsy reporting for podocytopathies should be standardized by including these prognostic morphologic features to inform risk stratification.

Published
2022
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50. Receiving four or fewer cycles of therapy predicts poor survival in newly diagnosed transplant-ineligible patients with myeloma who are treated with bortezomib-based induction

Author

Boyle, S, Wellard, C, Moore, EM, Blacklock, H, Harrison, SJ, Ho, PJ, Hocking, J, McQuilten, ZK, Quach, H, Spearing, R, Wood, EM, Spencer, A, Mollee, P, Boyle, S, Wellard, C, Moore, EM, Blacklock, H, Harrison, SJ, Ho, PJ, Hocking, J, McQuilten, ZK, Quach, H, Spearing, R, Wood, EM, Spencer, A, and Mollee, P

Published
2021

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