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2. Incidence of diabetes after SARS-CoV-2 infection in England and the implications of COVID-19 vaccination: a retrospective cohort study of 16 million people

Author

Al Arab, Marwa, Almaghrabi, Fatima, Andrews, Colm, Badrick, Ellena, Baz, Sarah, Beckford, Chelsea, Berman, Samantha, Bolton, Tom, Booth, Charlotte, Bowyer, Ruth, Boyd, Andy, Bridger-Staatz, Charis, Brophy, Sinead, Campbell, Archie, Campbell, Kirsteen C, Carnemolla, Alisia, Carpentieri, Jd, Cezard, Genevieve, Chaturvedi, Nishi, Cheetham, Nathan, Costello, Ruth, Cowling, Thomas, Crane, Matthew, Cuitun Coronado, Jose Ignacio, Curtis, Helen, Denaxas, Spiros, Denholm, Rachel, Di Gessa, Giorgio, Dobson, Richard, Douglas, Ian, Evans, Katharine M, Fang, Chao, Ferreira, Vanessa, Finnigan, Lucy, Fisher, Louis, Flaig, Robin, Folarin, Amos, Forbes, Harriet, Foster, Diane, Fox, Laura, Freydin, Maxim, Garcia, Paz, Gibson, Andy, Glen, Fiona, Goldacre, Ben, Goncalves Soares, Ana, Greaves, Felix, Green, Amelia, Green, Mark, Green, Michael, Griffith, Gareth, Hamill Howes, Lee, Hamilton, Olivia, Herbet, Annie, Herrett, Emily, Hopcroft, Lisa, Horne, Elsie, Hou, Bo, Hughes, Alun, Hulme, William, Huntley, Lizzie, Ip, Samantha, Jacques, Wels, Jezzard, Peter, Jones, Louise, Kanagaratnam, Arun, Karthikeyan Suseeladevi, Arun, Katikireddi, Vittal, Kellas, John, Kennedy, Jonathan I, Kibble, Milla, Knight, Rochelle, Knueppel, Anika, Kopasker, Daniel, Kromydas, Theocharis, Kwong, Alex, Langan, Sinead, Lemanska, Agnieszka, Lukaschuk, Elena, Mackenna, Brain, Macleod, John, Maddock, Jane, Mahalingasivam, Viyaasan, Mansfield, Kathryn, McArdle, Fintan, McCartney, Daniel, McEachan, Rosie, McElroy, Eoin, McLachlan, Stela, Mitchell, Ruth, Moltrecht, Bettina, Morley, Jess, Nab, Linda, Neubauer, Stefan, Nigrelli, Lidia, North, Teri, Northstone, Kate, Oakley, Jacqui, Palmer, Tom, Park, Chloe, Parker, Michael, Parsons, Sam, Patalay, Praveetha, Patel, Kishan, Perez-Reche, Francisco, Piechnik, Stefan, Piehlmaier, Dominik, Ploubidis, George, Rafeti, Elena, Raman, Betty, Ranjan, Yatharth, Rapala, Alicja, Rhead, Rebecca, Roberts, Amy, Sampri, Alexia, Sanders, Zeena-Britt, Santorelli, Gillian, Saunders, Laura C, Shah, Anoop, Shah, Syed Ahmar, Sharp, Steve, Shaw, Richard, Sheard, Laura, Sheikh, Aziz, Silverwood, Richard, Smeeth, Liam, Smith, Stephen, Stafford, Jean, Steptoe, Andrew, Sterne, Jonathan, Steves, Claire, Stewart, Callum, Taylor, Kurt, Tazare, John, Teece, Lucy, Thomas, Richard, Thompson, Ellen, Tilling, Kate, Timpson, Nicholas, Tomlinson, Laurie, Toms, Renin, Tunnicliffe, Elizabeth, Turner, Emma L, Walker, Alex, Walker, Venexia, Walter, Scott, Wang, Kevin, Wei, Yinghui, Whitehorn, Rebecca, Wielgoszewska, Bozena, Wild, James M, Willan, Kathryn, Willans, Robert, Williams, Dylan, Wong, Andrew, Wood, Angela, Woodward, Hannah, Wright, John, Yang, Tiffany, Zaninotto, Paola, Zheng, Bang, Zhu, Jingmin, Eastwood, Sophie, Horne, Elsie M F, Massey, Jon, Hopcroft, Lisa E M, Cuitun Coronado, Jose, Davy, Simon, Dillingham, Iain, Morton, Caroline, and Sterne, Jonathan A C

Published
2024
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4. Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: a population-based, observational cohort study using the OpenSAFELY platform

Author

Chaturvedi, Nishi, Park, Chloe, Carnemolla, Alisia, Williams, Dylan, Knueppel, Anika, Boyd, Andy, Turner, Emma L., Evans, Katharine M., Thomas, Richard, Berman, Samantha, McLachlan, Stela, Crane, Matthew, Whitehorn, Rebecca, Oakley, Jacqui, Foster, Diane, Woodward, Hannah, Campbell, Kirsteen C., Timpson, Nicholas, Kwong, Alex, Soares, Ana Goncalves, Griffith, Gareth, Toms, Renin, Jones, Louise, Annie, Herbert, Mitchell, Ruth, Palmer, Tom, Sterne, Jonathan, Walker, Venexia, Huntley, Lizzie, Fox, Laura, Denholm, Rachel, Knight, Rochelle, Northstone, Kate, Kanagaratnam, Arun, Horne, Elsie, Forbes, Harriet, North, Teri, Taylor, Kurt, Arab, Marwa A.L., Walker, Scott, Coronado, Jose I.C., Karthikeyan, Arun S., Ploubidis, George, Moltrecht, Bettina, Booth, Charlotte, Parsons, Sam, Wielgoszewska, Bozena, Bridger-Staatz, Charis, Steves, Claire, Thompson, Ellen, Garcia, Paz, Cheetham, Nathan, Bowyer, Ruth, Freydin, Maxim, Roberts, Amy, Goldacre, Ben, Walker, Alex, Morley, Jess, Hulme, William, Nab, Linda, Fisher, Louis, MacKenna, Brian, Andrews, Colm, Curtis, Helen, Hopcroft, Lisa, Green, Amelia, Patalay, Praveetha, Maddock, Jane, Patel, Kishan, Stafford, Jean, Jacques, Wels, Tilling, Kate, Macleod, John, McElroy, Eoin, Shah, Anoop, Silverwood, Richard, Denaxas, Spiros, Flaig, Robin, McCartney, Daniel, Campbell, Archie, Tomlinson, Laurie, Tazare, John, Zheng, Bang, Smeeth, Liam, Herrett, Emily, Cowling, Thomas, Mansfield, Kate, Costello, Ruth E., Wang, Kevin, Mansfield, Kathryn, Mahalingasivam, Viyaasan, Douglas, Ian, Langan, Sinead, Brophy, Sinead, Parker, Michael, Kennedy, Jonathan, McEachan, Rosie, Wright, John, Willan, Kathryn, Badrick, Ellena, Santorelli, Gillian, Yang, Tiffany, Hou, Bo, Steptoe, Andrew, Giorgio, Di Gessa, Zhu, Jingmin, Zaninotto, Paola, Wood, Angela, Cezard, Genevieve, Ip, Samantha, Bolton, Tom, Sampri, Alexia, Rafeti, Elena, Almaghrabi, Fatima, Sheikh, Aziz, Shah, Syed A., Katikireddi, Vittal, Shaw, Richard, Hamilton, Olivia, Green, Michael, Kromydas, Theocharis, Kopasker, Daniel, Greaves, Felix, Willans, Robert, Glen, Fiona, Sharp, Steve, Hughes, Alun, Wong, Andrew, Howes, Lee Hamill, Rapala, Alicja, Nigrelli, Lidia, McArdle, Fintan, Beckford, Chelsea, Raman, Betty, Dobson, Richard, Folarin, Amos, Stewart, Callum, Ranjan, Yatharth, Carpentieri, Jd, Sheard, Laura, Fang, Chao, Baz, Sarah, Gibson, Andy, Kellas, John, Neubauer, Stefan, Piechnik, Stefan, Lukaschuk, Elena, Saunders, Laura C., Wild, James M., Smith, Stephen, Jezzard, Peter, Tunnicliffe, Elizabeth, Sanders, Zeena-Britt, Finnigan, Lucy, Ferreira, Vanessa, Green, Mark, Rhead, Rebecca, Kibble, Milla, Wei, Yinghui, Lemanska, Agnieszka, Perez-Reche, Francisco, Piehlmaier, Dominik, Teece, Lucy, Parker, Edward, Walker, Alex J., Inglesby, Peter, Curtis, Helen J., Morton, Caroline E., Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian C.J., Hickman, George, Croker, Richard, Evans, David, Ward, Tom, DeVito, Nicholas J., Green, Amelia C.A., Massey, Jon, Smith, Rebecca M., Hulme, William J., Davy, Simon, Andrews, Colm D., Hopcroft, Lisa E.M., Drysdale, Henry, Dillingham, Iain, Park, Robin Y., Higgins, Rose, Cunningham, Christine, Wiedemann, Milan, Maude, Steven, Macdonald, Orla, Butler-Cole, Ben F.C., O'Dwyer, Thomas, Stables, Catherine L., Wood, Christopher, Brown, Andrew D., Speed, Victoria, Bridges, Lucy, Schaffer, Andrea L., Walters, Caroline E., Rentsch, Christopher T., Bhaskaran, Krishnan, Schultze, Anna, Williamson, Elizabeth J., McDonald, Helen I., Tomlinson, Laurie A., Mathur, Rohini, Eggo, Rosalind M., Wing, Kevin, Wong, Angel Y.S., Grieve, Richard, Grint, Daniel J., Mansfield, Kathryn E., Douglas, Ian J., Evans, Stephen J.W., Walker, Jemma L., Cowling, Thomas E., Herrett, Emily L., Parker, Edward P.K., Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, O'Hanlon, Shaun, Eavis, Alex, Jarvis, Richard, Avramov, Dima, Griffiths, Paul, Fowles, Aaron, Parkes, Nasreen, Nicholson, Brian, Perera, Rafael, Harrison, David, Khunti, Kamlesh, Sterne, Jonathan AC., Quint, Jennifer, Henderson, Alasdair D., Carreira, Helena, Bidulka, Patrick, Warren-Gash, Charlotte, Hayes, Joseph F., Quint, Jennifer K., Katikireddi, Srinivasa Vittal, and Langan, Sinéad M.

Published
2023
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5. Environmental factors and the human gut microbiome

Author

Bowyer, Ruth Catherine Emma, Steves, Claire Joanne, and Spector, Timothy David

Subjects
612.3
Abstract

There is increasing evidence that the composition of the human gut microbiome has a key role in health. Environmental factors predominate over the genetic in shaping the microbiome, yet while the potential factors contributing to the extensive inter-individual differences of microbiota are numerous, many have yet to be analysed. This thesis provides exploratory evidence of the relationship between wider environmental variables and microbiota composition and variance using the national TwinsUK cohort. The first part of this thesis provides a conceptual framework for the environmental factors potentially impacting the gut microbiota comprising four broad domains: hostintrinsic, host-lifestyle, passive and distal. Then, selecting key tractable variables from each conceptual domain, observational methods are used to analyse their association with microbiota composition characterised using 16s rRNA gene sequencing data from the TwinsUK cohort. Previous studies have focused on host-intrinsic (e.g. genetic, host health status) and host-lifestyle (e.g. diet, drugs) factors. Diet has emerged as a key environmental determinant, but the best method to capture the overall contribution of diet to variance in microbiota was not known. Therefore, in the second part of this thesis three dietary indices are compared, demonstrating that the 'Healthy Eating Index' captures the majority of variance attributable to diet. Next, the focus of the thesis is to provide examples of underexplored environmental factors, hypothesised to be associated with microbiota composition; distalenvironmental factors and passive-environmental factors. The models used to analyse each of these factors incorporated key covariates related to host intrinsic and host lifestyle factors. The passive environment captures inadvertently consumed factors that are products of the distal via host-lifestyle, such as food contaminants. The passive environment is explored via the composition of tap water, and results suggest, but are not conclusive of, an association with microbiota composition. Future study of passive environmental factors is therefore merited. Finally, the distal environment is examined. Distal-environmental factors are those associated with the wider geosocial and spatial environment of the host. Here, it is explored via socioeconomic status and the host's habitat; both studies demonstrate these understudied factors to have significant associations with multiple measures of the microbiota. These findings raise the possibility that the microbiota mediate the effect of distal factors on host health. In summary, within this thesis a conceptual framework is used to explore understudied environmental associates of microbiota variance. Although not comprehensive, the examples studied provide evidence that distal and passive environmental factors merit future exploration. The results are of interest not only in furthering understanding of influencers of microbiota composition, but also in contributing to knowledge of how an individual's spatial environment interacts with their health.

Published
2019

6. Psychological distress, depression, anxiety, and life satisfaction following COVID-19 infection: evidence from 11 UK longitudinal population studies

Author

Thompson, Ellen J, Stafford, Jean, Moltrecht, Bettina, Huggins, Charlotte F, Kwong, Alex S F, Shaw, Richard J, Zaninotto, Paola, Patel, Kishan, Silverwood, Richard J, McElroy, Eoin, Pierce, Matthias, Green, Michael J, Bowyer, Ruth C E, Maddock, Jane, Tilling, Kate, Katikireddi, S Vittal, Ploubidis, George B, Porteous, David J, Timpson, Nic, Chaturvedi, Nish, Steves, Claire J, and Patalay, Praveetha

Published
2022
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7. Mental and social wellbeing and the UK coronavirus job retention scheme: Evidence from nine longitudinal studies

Author

Jacques Wels, Booth, Charlotte, Wielgoszewska, Bożena, Green, Michael J., Di Gessa, Giorgio, Huggins, Charlotte F., Griffith, Gareth J., Kwong, Alex S.F., Bowyer, Ruth C.E., Maddock, Jane, Patalay, Praveetha, Silverwood, Richard J., Fitzsimons, Emla, Shaw, Richard, Thompson, Ellen J., Steptoe, Andrew, Hughes, Alun, Chaturvedi, Nishi, Steves, Claire J., Katikireddi, Srinivasa Vittal, and Ploubidis, George B.

Published
2022
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10. Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records

Author

Thompson, Ellen J., Williams, Dylan M., Walker, Alex J., Mitchell, Ruth E., Niedzwiedz, Claire L., Yang, Tiffany C., Huggins, Charlotte F., Kwong, Alex S. F., Silverwood, Richard J., Di Gessa, Giorgio, Bowyer, Ruth C. E., Northstone, Kate, Hou, Bo, Green, Michael J., Dodgeon, Brian, Doores, Katie J., Duncan, Emma L., Williams, Frances M. K., Steptoe, Andrew, Porteous, David J., McEachan, Rosemary R. C., Tomlinson, Laurie, Goldacre, Ben, Patalay, Praveetha, Ploubidis, George B., Katikireddi, Srinivasa Vittal, Tilling, Kate, Rentsch, Christopher T., Timpson, Nicholas J., Chaturvedi, Nishi, and Steves, Claire J.

Published
2022
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14. Attributes and predictors of long COVID

Author

Sudre, Carole H., Murray, Benjamin, Varsavsky, Thomas, Graham, Mark S., Penfold, Rose S., Bowyer, Ruth C., Pujol, Joan Capdevila, Klaser, Kerstin, Antonelli, Michela, Canas, Liane S., Molteni, Erika, Modat, Marc, Cardoso, M. Jorge, May, Anna, Ganesh, Sajaysurya, Davies, Richard, and Nguyen, Long H.

Subjects
Biological sciences, Health
Abstract

Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called 'long COVID', are rising but little is known about prevalence, risk factors or whether it is possible to predict a protracted course early in the disease. We analyzed data from 4,182 incident cases of COVID-19 in which individuals self-reported their symptoms prospectively in the COVID Symptom Study app.sup.1. A total of 558 (13.3%) participants reported symptoms lasting [greater than or equal to]28 days, 189 (4.5%) for [greater than or equal to]8 weeks and 95 (2.3%) for [greater than or equal to]12 weeks. Long COVID was characterized by symptoms of fatigue, headache, dyspnea and anosmia and was more likely with increasing age and body mass index and female sex. Experiencing more than five symptoms during the first week of illness was associated with long COVID (odds ratio = 3.53 (2.76-4.50)). A simple model to distinguish between short COVID and long COVID at 7 days (total sample size, n = 2,149) showed an area under the curve of the receiver operating characteristic curve of 76%, with replication in an independent sample of 2,472 individuals who were positive for severe acute respiratory syndrome coronavirus 2. This model could be used to identify individuals at risk of long COVID for trials of prevention or treatment and to plan education and rehabilitation services. Analysis of data from the COVID Symptom Study app reveals fatigue, headache, dyspnea and anosmia as key attributes of long COVID, with those experiencing five or more symptoms during the first week of being at increased risk of prolonged disease., Author(s): Carole H. Sudre [sup.1] [sup.2] [sup.3] , Benjamin Murray [sup.3] , Thomas Varsavsky [sup.3] , Mark S. Graham [sup.3] , Rose S. Penfold [sup.4] , Ruth C. Bowyer [sup.5] [...]

Published
2021
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16. Real-time tracking of self-reported symptoms to predict potential COVID-19

Author

Menni, Cristina, Valdes, Ana M., Freidin, Maxim B., Sudre, Carole H., Nguyen, Long H., Drew, David A., Ganesh, Sajaysurya, Varsavsky, Thomas, Cardoso, M. Jorge, El-Sayed Moustafa, Julia S., Visconti, Alessia, Hysi, Pirro, Bowyer, Ruth C. E., Mangino, Massimo, Falchi, Mario, Wolf, Jonathan, Ourselin, Sebastien, Chan, Andrew T., Steves, Claire J., and Spector, Tim D.

Published
2020
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17. Incidence of diabetes after SARS-CoV-2 infection in England and the implications of COVID-19 vaccination: a retrospective cohort study of 16 million people

Author

Taylor, Kurt, Eastwood, Sophie, Walker, Venexia, Cezard, Genevieve, Knight, Rochelle, Al Arab, Marwa, Wei, Yinghui, Horne, Elsie M F, Teece, Lucy, Forbes, Harriet, Walker, Alex, Fisher, Louis, Massey, Jon, Hopcroft, Lisa E M, Palmer, Tom, Cuitun Coronado, Jose, Ip, Samantha, Davy, Simon, Dillingham, Iain, Morton, Caroline, Greaves, Felix, Macleod, John, Goldacre, Ben, Wood, Angela, Chaturvedi, Nishi, Sterne, Jonathan A C, Denholm, Rachel, Al Arab, Marwa, Almaghrabi, Fatima, Andrews, Colm, Badrick, Ellena, Baz, Sarah, Beckford, Chelsea, Berman, Samantha, Bolton, Tom, Booth, Charlotte, Bowyer, Ruth, Boyd, Andy, Bridger-Staatz, Charis, Brophy, Sinead, Campbell, Archie, Campbell, Kirsteen C, Carnemolla, Alisia, Carpentieri, Jd, Cezard, Genevieve, Chaturvedi, Nishi, Cheetham, Nathan, Costello, Ruth, Cowling, Thomas, Crane, Matthew, Cuitun Coronado, Jose Ignacio, Curtis, Helen, Denaxas, Spiros, Denholm, Rachel, Di Gessa, Giorgio, Dobson, Richard, Douglas, Ian, Evans, Katharine M, Fang, Chao, Ferreira, Vanessa, Finnigan, Lucy, Fisher, Louis, Flaig, Robin, Folarin, Amos, Forbes, Harriet, Foster, Diane, Fox, Laura, Freydin, Maxim, Garcia, Paz, Gibson, Andy, Glen, Fiona, Goldacre, Ben, Goncalves Soares, Ana, Greaves, Felix, Green, Amelia, Green, Mark, Green, Michael, Griffith, Gareth, Hamill Howes, Lee, Hamilton, Olivia, Herbet, Annie, Herrett, Emily, Hopcroft, Lisa, Horne, Elsie, Hou, Bo, Hughes, Alun, Hulme, William, Huntley, Lizzie, Ip, Samantha, Jacques, Wels, Jezzard, Peter, Jones, Louise, Kanagaratnam, Arun, Karthikeyan Suseeladevi, Arun, Katikireddi, Vittal, Kellas, John, Kennedy, Jonathan I, Kibble, Milla, Knight, Rochelle, Knueppel, Anika, Kopasker, Daniel, Kromydas, Theocharis, Kwong, Alex, Langan, Sinead, Lemanska, Agnieszka, Lukaschuk, Elena, Mackenna, Brain, Macleod, John, Maddock, Jane, Mahalingasivam, Viyaasan, Mansfield, Kathryn, McArdle, Fintan, McCartney, Daniel, McEachan, Rosie, McElroy, Eoin, McLachlan, Stela, Mitchell, Ruth, Moltrecht, Bettina, Morley, Jess, Nab, Linda, Neubauer, Stefan, Nigrelli, Lidia, North, Teri, Northstone, Kate, Oakley, Jacqui, Palmer, Tom, Park, Chloe, Parker, Michael, Parsons, Sam, Patalay, Praveetha, Patel, Kishan, Perez-Reche, Francisco, Piechnik, Stefan, Piehlmaier, Dominik, Ploubidis, George, Rafeti, Elena, Raman, Betty, Ranjan, Yatharth, Rapala, Alicja, Rhead, Rebecca, Roberts, Amy, Sampri, Alexia, Sanders, Zeena-Britt, Santorelli, Gillian, Saunders, Laura C, Shah, Anoop, Shah, Syed Ahmar, Sharp, Steve, Shaw, Richard, Sheard, Laura, Sheikh, Aziz, Silverwood, Richard, Smeeth, Liam, Smith, Stephen, Stafford, Jean, Steptoe, Andrew, Sterne, Jonathan, Steves, Claire, Stewart, Callum, Taylor, Kurt, Tazare, John, Teece, Lucy, Thomas, Richard, Thompson, Ellen, Tilling, Kate, Timpson, Nicholas, Tomlinson, Laurie, Toms, Renin, Tunnicliffe, Elizabeth, Turner, Emma L, Walker, Alex, Walker, Venexia, Walter, Scott, Wang, Kevin, Wei, Yinghui, Whitehorn, Rebecca, Wielgoszewska, Bozena, Wild, James M, Willan, Kathryn, Willans, Robert, Williams, Dylan, Wong, Andrew, Wood, Angela, Woodward, Hannah, Wright, John, Yang, Tiffany, Zaninotto, Paola, Zheng, Bang, and Zhu, Jingmin

Abstract

Some studies have shown that the incidence of type 2 diabetes increases after a diagnosis of COVID-19, although the evidence is not conclusive. However, the effects of the COVID-19 vaccine on this association, or the effect on other diabetes subtypes, are not clear. We aimed to investigate the association between COVID-19 and incidence of type 2, type 1, gestational and non-specific diabetes, and the effect of COVID- 19 vaccination, up to 52 weeks after diagnosis.

Published
2024
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18. Associations between SARS-CoV-2 infection and subsequent economic inactivity and employment status: pooled analyses of five linked longitudinal surveys

Author

Shaw, Richard J, primary, Rhead, Rebecca, additional, Silverwood, Richard J, additional, Wels, Jacques, additional, Zhu, Jingmin, additional, Hamilton, Olivia KL, additional, Gessa, Giorgio Di, additional, Bowyer, Ruth CE, additional, Moltrecht, Bettina, additional, Green, Michael J, additional, Demou, Evangelia, additional, Pattaro, Serena, additional, Zaninotto, Paola, additional, Boyd, Andy, additional, Greaves, Felix, additional, Chaturvedi, Nish, additional, Ploubidis, George B., additional, and Katikireddi, Srinivasa Vittal, additional

Published
2023
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19. Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: a population-based, observational cohort study using the OpenSAFELY platform

Author

Costello, Ruth E., primary, Tazare, John, additional, Piehlmaier, Dominik, additional, Herrett, Emily, additional, Parker, Edward P.K., additional, Zheng, Bang, additional, Mansfield, Kathryn E., additional, Henderson, Alasdair D., additional, Carreira, Helena, additional, Bidulka, Patrick, additional, Wong, Angel Y.S., additional, Warren-Gash, Charlotte, additional, Hayes, Joseph F., additional, Quint, Jennifer K., additional, MacKenna, Brian, additional, Mehrkar, Amir, additional, Eggo, Rosalind M., additional, Katikireddi, Srinivasa Vittal, additional, Tomlinson, Laurie, additional, Langan, Sinéad M., additional, Mathur, Rohini, additional, Chaturvedi, Nishi, additional, Park, Chloe, additional, Carnemolla, Alisia, additional, Williams, Dylan, additional, Knueppel, Anika, additional, Boyd, Andy, additional, Turner, Emma L., additional, Evans, Katharine M., additional, Thomas, Richard, additional, Berman, Samantha, additional, McLachlan, Stela, additional, Crane, Matthew, additional, Whitehorn, Rebecca, additional, Oakley, Jacqui, additional, Foster, Diane, additional, Woodward, Hannah, additional, Campbell, Kirsteen C., additional, Timpson, Nicholas, additional, Kwong, Alex, additional, Soares, Ana Goncalves, additional, Griffith, Gareth, additional, Toms, Renin, additional, Jones, Louise, additional, Annie, Herbert, additional, Mitchell, Ruth, additional, Palmer, Tom, additional, Sterne, Jonathan, additional, Walker, Venexia, additional, Huntley, Lizzie, additional, Fox, Laura, additional, Denholm, Rachel, additional, Knight, Rochelle, additional, Northstone, Kate, additional, Kanagaratnam, Arun, additional, Horne, Elsie, additional, Forbes, Harriet, additional, North, Teri, additional, Taylor, Kurt, additional, Arab, Marwa A.L., additional, Walker, Scott, additional, Coronado, Jose I.C., additional, Karthikeyan, Arun S., additional, Ploubidis, George, additional, Moltrecht, Bettina, additional, Booth, Charlotte, additional, Parsons, Sam, additional, Wielgoszewska, Bozena, additional, Bridger-Staatz, Charis, additional, Steves, Claire, additional, Thompson, Ellen, additional, Garcia, Paz, additional, Cheetham, Nathan, additional, Bowyer, Ruth, additional, Freydin, Maxim, additional, Roberts, Amy, additional, Goldacre, Ben, additional, Walker, Alex, additional, Morley, Jess, additional, Hulme, William, additional, Nab, Linda, additional, Fisher, Louis, additional, Andrews, Colm, additional, Curtis, Helen, additional, Hopcroft, Lisa, additional, Green, Amelia, additional, Patalay, Praveetha, additional, Maddock, Jane, additional, Patel, Kishan, additional, Stafford, Jean, additional, Jacques, Wels, additional, Tilling, Kate, additional, Macleod, John, additional, McElroy, Eoin, additional, Shah, Anoop, additional, Silverwood, Richard, additional, Denaxas, Spiros, additional, Flaig, Robin, additional, McCartney, Daniel, additional, Campbell, Archie, additional, Smeeth, Liam, additional, Cowling, Thomas, additional, Mansfield, Kate, additional, Costello, Ruth E., additional, Wang, Kevin, additional, Mansfield, Kathryn, additional, Mahalingasivam, Viyaasan, additional, Douglas, Ian, additional, Langan, Sinead, additional, Brophy, Sinead, additional, Parker, Michael, additional, Kennedy, Jonathan, additional, McEachan, Rosie, additional, Wright, John, additional, Willan, Kathryn, additional, Badrick, Ellena, additional, Santorelli, Gillian, additional, Yang, Tiffany, additional, Hou, Bo, additional, Steptoe, Andrew, additional, Giorgio, Di Gessa, additional, Zhu, Jingmin, additional, Zaninotto, Paola, additional, Wood, Angela, additional, Cezard, Genevieve, additional, Ip, Samantha, additional, Bolton, Tom, additional, Sampri, Alexia, additional, Rafeti, Elena, additional, Almaghrabi, Fatima, additional, Sheikh, Aziz, additional, Shah, Syed A., additional, Katikireddi, Vittal, additional, Shaw, Richard, additional, Hamilton, Olivia, additional, Green, Michael, additional, Kromydas, Theocharis, additional, Kopasker, Daniel, additional, Greaves, Felix, additional, Willans, Robert, additional, Glen, Fiona, additional, Sharp, Steve, additional, Hughes, Alun, additional, Wong, Andrew, additional, Howes, Lee Hamill, additional, Rapala, Alicja, additional, Nigrelli, Lidia, additional, McArdle, Fintan, additional, Beckford, Chelsea, additional, Raman, Betty, additional, Dobson, Richard, additional, Folarin, Amos, additional, Stewart, Callum, additional, Ranjan, Yatharth, additional, Carpentieri, Jd, additional, Sheard, Laura, additional, Fang, Chao, additional, Baz, Sarah, additional, Gibson, Andy, additional, Kellas, John, additional, Neubauer, Stefan, additional, Piechnik, Stefan, additional, Lukaschuk, Elena, additional, Saunders, Laura C., additional, Wild, James M., additional, Smith, Stephen, additional, Jezzard, Peter, additional, Tunnicliffe, Elizabeth, additional, Sanders, Zeena-Britt, additional, Finnigan, Lucy, additional, Ferreira, Vanessa, additional, Green, Mark, additional, Rhead, Rebecca, additional, Kibble, Milla, additional, Wei, Yinghui, additional, Lemanska, Agnieszka, additional, Perez-Reche, Francisco, additional, Teece, Lucy, additional, Parker, Edward, additional, Walker, Alex J., additional, Inglesby, Peter, additional, Curtis, Helen J., additional, Morton, Caroline E., additional, Morley, Jessica, additional, Bacon, Sebastian C.J., additional, Hickman, George, additional, Croker, Richard, additional, Evans, David, additional, Ward, Tom, additional, DeVito, Nicholas J., additional, Green, Amelia C.A., additional, Massey, Jon, additional, Smith, Rebecca M., additional, Hulme, William J., additional, Davy, Simon, additional, Andrews, Colm D., additional, Hopcroft, Lisa E.M., additional, Drysdale, Henry, additional, Dillingham, Iain, additional, Park, Robin Y., additional, Higgins, Rose, additional, Cunningham, Christine, additional, Wiedemann, Milan, additional, Maude, Steven, additional, Macdonald, Orla, additional, Butler-Cole, Ben F.C., additional, O'Dwyer, Thomas, additional, Stables, Catherine L., additional, Wood, Christopher, additional, Brown, Andrew D., additional, Speed, Victoria, additional, Bridges, Lucy, additional, Schaffer, Andrea L., additional, Walters, Caroline E., additional, Rentsch, Christopher T., additional, Bhaskaran, Krishnan, additional, Schultze, Anna, additional, Williamson, Elizabeth J., additional, McDonald, Helen I., additional, Tomlinson, Laurie A., additional, Wing, Kevin, additional, Grieve, Richard, additional, Grint, Daniel J., additional, Douglas, Ian J., additional, Evans, Stephen J.W., additional, Walker, Jemma L., additional, Cowling, Thomas E., additional, Herrett, Emily L., additional, Bates, Christopher, additional, Cockburn, Jonathan, additional, Parry, John, additional, Hester, Frank, additional, Harper, Sam, additional, O'Hanlon, Shaun, additional, Eavis, Alex, additional, Jarvis, Richard, additional, Avramov, Dima, additional, Griffiths, Paul, additional, Fowles, Aaron, additional, Parkes, Nasreen, additional, Nicholson, Brian, additional, Perera, Rafael, additional, Harrison, David, additional, Khunti, Kamlesh, additional, Sterne, Jonathan AC., additional, and Quint, Jennifer, additional

Published
2023
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20. Effect of gut microbiome modulation on muscle function and cognition: the PROMOTe randomised controlled trial.

Author

Lochlainn, Mary Ni, Bowyer, Ruth C. E., Moll, Janne Marie, García, María Paz, Wadge, Samuel, Baleanu, Andrei-Florin, Nessa, Ayrun, Sheedy, Alyce, Akdag, Gulsah, Hart, Deborah, Raffaele, Giulia, Seed, Paul T., Murphy, Caroline, Harridge, Stephen D. R., Welch, Ailsa A., Greig, Carolyn, Whelan, Kevin, and Steves, Claire J.

Abstract

Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut microbiota may play a role in both anabolic resistance of older muscle, and cognition. In this placebo controlled double blinded randomised controlled trial of 36 twin pairs (72 individuals), aged ≥60, each twin pair are block randomised to receive either placebo or prebiotic daily for 12 weeks. Resistance exercise and branched chain amino acid (BCAA) supplementation is prescribed to all participants. Outcomes are physical function and cognition. The trial is carried out remotely using video visits, online questionnaires and cognitive testing, and posting of equipment and biological samples. The prebiotic supplement is well tolerated and results in a changed gut microbiome [e.g., increased relative Bifidobacterium abundance]. There is no significant difference between prebiotic and placebo for the primary outcome of chair rise time (β = 0.579; 95% CI -1.080-2.239 p = 0.494). The prebiotic improves cognition (factor score versus placebo (β = -0.482; 95% CI,-0.813, -0.141; p = 0.014)). Our results demonstrate that cheap and readily available gut microbiome interventions may improve cognition in our ageing population. We illustrate the feasibility of remotely delivered trials for older people, which could reduce under-representation of older people in clinical trials. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Characterising patterns of COVID-19 and long COVID symptoms: evidence from nine UK longitudinal studies

Author

Bowyer, Ruth CE, Huggins, Charlotte, Toms, Renin, Shaw, Richard J, Hou, Bo, Thompson, Ellen J, Kwong, Alex SF, Williams, Dylan M, Kibble, Milla, Ploubidis, George B, Timpson, Nicholas J, Sterne, Jonathan AC, Chaturvedi, Nishi, Steves, Claire J, Tilling, Kate, Silverwood, Richard J, CONVALESCENCE Study, Bowyer, Ruth CE [0000-0002-6941-8160], Huggins, Charlotte [0000-0001-5960-4771], Toms, Renin [0000-0002-6922-1448], Shaw, Richard J [0000-0002-7906-6066], Hou, Bo [0000-0001-5337-6560], Thompson, Ellen J [0000-0003-2118-821X], Kwong, Alex SF [0000-0003-1953-2771], Williams, Dylan M [0000-0002-3825-2487], Ploubidis, George B [0000-0002-8198-5790], Timpson, Nicholas J [0000-0002-7141-9189], Sterne, Jonathan AC [0000-0001-8496-6053], Chaturvedi, Nishi [0000-0002-6211-2775], Steves, Claire J [0000-0002-4910-0489], Tilling, Kate [0000-0002-1010-8926], Silverwood, Richard J [0000-0002-2744-1194], and Apollo - University of Cambridge Repository

Subjects
Long COVID, Post-Acute COVID-19 Syndrome, Dyspnea, Longitudinal studies, COVID-19, Humans, Pain, Symptom patterns, Clustering, Fatigue, United Kingdom
Abstract

Funder: Chronic Disease Research Foundation; doi: http://dx.doi.org/10.13039/100011721, Funder: Zoe Global Ltd, Multiple studies across global populations have established the primary symptoms characterising Coronavirus Disease 2019 (COVID-19) and long COVID. However, as symptoms may also occur in the absence of COVID-19, a lack of appropriate controls has often meant that specificity of symptoms to acute COVID-19 or long COVID, and the extent and length of time for which they are elevated after COVID-19, could not be examined. We analysed individual symptom prevalences and characterised patterns of COVID-19 and long COVID symptoms across nine UK longitudinal studies, totalling over 42,000 participants. Conducting latent class analyses separately in three groups ('no COVID-19', 'COVID-19 in last 12 weeks', 'COVID-19 > 12 weeks ago'), the data did not support the presence of more than two distinct symptom patterns, representing high and low symptom burden, in each group. Comparing the high symptom burden classes between the 'COVID-19 in last 12 weeks' and 'no COVID-19' groups we identified symptoms characteristic of acute COVID-19, including loss of taste and smell, fatigue, cough, shortness of breath and muscle pains or aches. Comparing the high symptom burden classes between the 'COVID-19 > 12 weeks ago' and 'no COVID-19' groups we identified symptoms characteristic of long COVID, including fatigue, shortness of breath, muscle pain or aches, difficulty concentrating and chest tightness. The identified symptom patterns among individuals with COVID-19 > 12 weeks ago were strongly associated with self-reported length of time unable to function as normal due to COVID-19 symptoms, suggesting that the symptom pattern identified corresponds to long COVID. Building the evidence base regarding typical long COVID symptoms will improve diagnosis of this condition and the ability to elicit underlying biological mechanisms, leading to better patient access to treatment and services.

Published
2023

22. Author Correction: Attributes and predictors of long COVID

Author

Sudre, Carole H., Murray, Benjamin, Varsavsky, Thomas, Graham, Mark S., Penfold, Rose S., Bowyer, Ruth C., Pujol, Joan Capdevila, Klaser, Kerstin, Antonelli, Michela, Canas, Liane S., Molteni, Erika, Modat, Marc, Jorge Cardoso, M., May, Anna, Ganesh, Sajaysurya, Davies, Richard, Nguyen, Long H., Drew, David A., Astley, Christina M., Joshi, Amit D., Merino, Jordi, Tsereteli, Neli, Fall, Tove, Gomez, Maria F., Duncan, Emma L., Menni, Cristina, Williams, Frances M. K., Franks, Paul W., Chan, Andrew T., Wolf, Jonathan, Ourselin, Sebastien, Spector, Tim, and Steves, Claire J.

Published
2021
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23. Associations between SARS-CoV-2 infection and subsequent economic inactivity and employment status: pooled analyses of five linked longitudinal surveys.

Author

Shaw, Richard John, Rhead, Rebecca, Silverwood, Richard J., Jacques, Wels, Zhu, Jingmin, Hamilton, Olivia Kl, Gessa, Giorgio Di, Bowyer, Ruth Ce, Moltrecht, Bettina, Green, Michael J, Demou, Evangelia, Pattaro, Serena, Zaninotto, Paola, Boyd, Andy, Greaves, Felix, Chaturvedi, Nish, Ploubidis, George B., Katikireddi, Srinivasa Vittal, Shaw, Richard John, Rhead, Rebecca, Silverwood, Richard J., Jacques, Wels, Zhu, Jingmin, Hamilton, Olivia Kl, Gessa, Giorgio Di, Bowyer, Ruth Ce, Moltrecht, Bettina, Green, Michael J, Demou, Evangelia, Pattaro, Serena, Zaninotto, Paola, Boyd, Andy, Greaves, Felix, Chaturvedi, Nish, Ploubidis, George B., and Katikireddi, Srinivasa Vittal

Abstract

Following the acute phase of the COVID-19 pandemic, record numbers of people became economically inactive (i.e. neither working nor looking for work), or non-employed (including unemployed job seekers and economically inactive people). A possible explanation is people leaving the workforce after contracting COVID-19. We investigated whether testing positive for SARS-CoV-2 is related to subsequent economic inactivity and non-employment, among people employed pre-pandemic., info:eu-repo/semantics/published

Published
2023

27. Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies

Author

Cheetham, Nathan J, primary, Kibble, Milla, additional, Wong, Andrew, additional, Silverwood, Richard J, additional, Knuppel, Anika, additional, Williams, Dylan M, additional, Hamilton, Olivia KL, additional, Lee, Paul H, additional, Bridger Staatz, Charis, additional, Di Gessa, Giorgio, additional, Zhu, Jingmin, additional, Katikireddi, Srinivasa Vittal, additional, Ploubidis, George B, additional, Thompson, Ellen J, additional, Bowyer, Ruth CE, additional, Zhang, Xinyuan, additional, Abbasian, Golboo, additional, Garcia, Maria Paz, additional, Hart, Deborah, additional, Seow, Jeffrey, additional, Graham, Carl, additional, Kouphou, Neophytos, additional, Acors, Sam, additional, Malim, Michael H, additional, Mitchell, Ruth E, additional, Northstone, Kate, additional, Major-Smith, Daniel, additional, Matthews, Sarah, additional, Breeze, Thomas, additional, Crawford, Michael, additional, Molloy, Lynn, additional, Kwong, Alex SF, additional, Doores, Katie, additional, chaturvedi, Nishi, additional, Duncan, Emma L, additional, Timpson, Nicholas J, additional, and Steves, Claire J, additional

Published
2023
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29. PPI‐Induced Changes in Plasma Metabolite Levels Influence Total Hip Bone Mineral Density in a UK Cohort

Author

Zhang, Xinyuan, primary, Adebayo, Adewale S., additional, Wang, Dongmeng, additional, Raza, Yasrab, additional, Tomlinson, Max, additional, Dooley, Hannah, additional, Bowyer, Ruth C.E., additional, Small, Kerrin S., additional, Steves, Claire J., additional, Spector, Tim D., additional, Duncan, Emma L., additional, Visconti, Alessia, additional, and Falchi, Mario, additional

Published
2022
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30. A Data Integration Approach to Estimating Personal Exposures to Air Pollution

Author

Thomas, Matthew L, primary, Shaddick, Gavin, additional, Topping, David, additional, Morrissey, Karyn, additional, Brannan, Thomas J., additional, Diessner, Mike, additional, Bowyer, Ruth C. E., additional, Siegert, Stefan, additional, Coe, Hugh, additional, Evans, James, additional, Benitez-Paez, Fernando, additional, and Zidek, James V., additional

Published
2022
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31. Socio-demographic determinants of COVID-19: a coordinated analysis of eight longitudinal studies and electronic health records

Author

Wels, Jacques, Hamilton, Olivia, Moltrecht, Bettina, Andrews, Colm, Rhead, Rebecca, Zhu, Jingmin, Bowyer, Ruth, Santorelli, Gillian, Maddock, Jane, Di Gessa, Giorgio, Silverwood, Richard, Chaturvedi, Nishi, Green, Michael, Shaw, Richard, Green, Mark, Steves, Claire, Katikireddi, Vittal, Ploubidis, George, and Wielgoszewska, Bozena

Subjects
Medicine and Health Sciences, Public Health
Abstract

Although everybody is at risk of catching SARS-Cov-2, recent research has shown that some people are more at risk than others because of personal characteristics or circumstances such as sex, ethnicity, or their financial situation. In this study, we aim to understand whether differences in peoples’ characteristics and circumstances increase their risk of catching SARS-Cov-2. To do this, we will use statistical models with data from eight research studies. We will also look at whether certain combinations of characteristics and circumstances increase someone’s risk of reporting COVID-19 disease symptoms. For example, we are interested in whether having different combinations of ethnic identity, sex and education increases or decreases the risk of reporting COVID-19 symptoms, or not. Since the core eight studies only include participants who signed up to our research studies, we will run similar analyses using a larger database, which contains health record data for up to 24 million people in England, to see if they find similar results. We hope that the results of this study will tell us which groups of people are at the highest risk of reporting COVID-19 symptoms. We will share the results of this study with policy makers and hope that it will guide decisions about how to support and protect the most vulnerable groups of people in our society.

Published
2023
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32. Author response: Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies

Author

Cheetham, Nathan J, primary, Kibble, Milla, additional, Wong, Andrew, additional, Silverwood, Richard J, additional, Knuppel, Anika, additional, Williams, Dylan M, additional, Hamilton, Olivia KL, additional, Lee, Paul H, additional, Bridger Staatz, Charis, additional, Di Gessa, Giorgio, additional, Zhu, Jingmin, additional, Katikireddi, Srinivasa Vittal, additional, Ploubidis, George B, additional, Thompson, Ellen J, additional, Bowyer, Ruth CE, additional, Zhang, Xinyuan, additional, Abbasian, Golboo, additional, Garcia, Maria Paz, additional, Hart, Deborah, additional, Seow, Jeffrey, additional, Graham, Carl, additional, Kouphou, Neophytos, additional, Acors, Sam, additional, Malim, Michael H, additional, Mitchell, Ruth E, additional, Northstone, Kate, additional, Major-Smith, Daniel, additional, Matthews, Sarah, additional, Breeze, Thomas, additional, Crawford, Michael, additional, Molloy, Lynn, additional, Kwong, Alex SF, additional, Doores, Katie, additional, Chaturvedi, Nishi, additional, Duncan, Emma L, additional, Timpson, Nicholas J, additional, and Steves, Claire J, additional

Published
2022
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33. Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans

Author

Roberts, Amy L, primary, Morea, Alessandro, additional, Amar, Ariella, additional, Zito, Antonino, additional, El-Sayed Moustafa, Julia S, additional, Tomlinson, Max, additional, Bowyer, Ruth CE, additional, Zhang, Xinyuan, additional, Christiansen, Colette, additional, Costeira, Ricardo, additional, Steves, Claire J, additional, Mangino, Massimo, additional, Bell, Jordana T, additional, Wong, Chloe CY, additional, Vyse, Timothy J, additional, and Small, Kerrin S, additional

Published
2022
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34. Author response: Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans

Author

Roberts, Amy L, primary, Morea, Alessandro, additional, Amar, Ariella, additional, Zito, Antonino, additional, El-Sayed Moustafa, Julia S, additional, Tomlinson, Max, additional, Bowyer, Ruth CE, additional, Zhang, Xinyuan, additional, Christiansen, Colette, additional, Costeira, Ricardo, additional, Steves, Claire J, additional, Mangino, Massimo, additional, Bell, Jordana T, additional, Wong, Chloe CY, additional, Vyse, Timothy J, additional, and Small, Kerrin S, additional

Published
2022
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37. The TwinsUK Covid Personal Experience (CoPE) Study

Author

Bowyer, Ruth, Thompson, Ellen, Steves, Claire, Suthahar, Aaruthy, Sharma, Pramila, Hart, Deborah, Garcia, Maria, and Horsfall, Rachel

Subjects
Medicine and Health Sciences, COVID-19
Abstract

In response to the coronavirus disease 2019 (COVID-19) pandemic and the resulting UK ‘lockdown’ restrictions, our team developed the TwinsUK COVID-19 personal experience (CoPE) questionnaire. The questionnaire has and will be been sent to participants across multiple waves to encompass the whole span of the pandemic, commencing April 2020. It captures a variety of measures, including those relating to physical health, mental health and well-being and socioeconomic circumstances.

Published
2022
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38. Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records

Author

Thompson, Ellen J, Williams, Dylan M, Walker, Alex J, Mitchell, Ruth E, Niedzwiedz, Claire L, Yang, Tiffany C, Huggins, Charlotte F, Kwong, Alex SF, Silverwood, Richard J, Di Gessa, Giorgio, Bowyer, Ruth CE, Northstone, Kate, Hou, Bo, Green, Michael J, Dodgeon, Brian, Doores, Katie J, Duncan, Emma L, Williams, Frances MK, OpenSAFELY Collaborative, Steptoe, Andrew, Porteous, David J, McEachan, Rosemary RC, Tomlinson, Laurie, Goldacre, Ben, Patalay, Praveetha, Ploubidis, George B, Katikireddi, Srinivasa Vittal, Tilling, Kate, Rentsch, Christopher T, Timpson, Nicholas J, Chaturvedi, Nishi, and Steves, Claire J

Abstract

The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden and possible causes of long COVID in the community, we coordinated analyses of survey data from 6907 individuals with self-reported COVID-19 from 10 UK longitudinal study (LS) samples and 1.1 million individuals with COVID-19 diagnostic codes in electronic healthcare records (EHR) collected by spring 2021. Proportions of presumed COVID-19 cases in LS reporting any symptoms for 12+ weeks ranged from 7.8% and 17% (with 1.2 to 4.8% reporting debilitating symptoms). Increasing age, female sex, white ethnicity, poor pre-pandemic general and mental health, overweight/obesity, and asthma were associated with prolonged symptoms in both LS and EHR data, but findings for other factors, such as cardio-metabolic parameters, were inconclusive.

Published
2022

39. Characterising patterns of COVID-19 and long COVID symptoms: Evidence from nine UK longitudinal studies

Author

Bowyer, Ruth C. E., primary, Huggins, Charlotte, additional, Toms, Renin, additional, Shaw, Richard J., additional, Hou, Bo, additional, Thompson, Ellen J., additional, Kwong, Alex, additional, Williams, Dylan, additional, Kibble, Milla, additional, Ploubidis, George B., additional, Timpson, Nic, additional, Sterne, Jonathan, additional, Chaturvedi, Nish, additional, Steves, Claire J., additional, Tilling, Kate, additional, and Silverwood, Richard J., additional

Published
2022
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40. Mental and social wellbeing and the UK coronavirus job retention scheme: Evidence from nine longitudinal studies

Author

Jacques, Wels, Booth, Charlotte, Wielgoszewska, Bożena, Green, Michael J, Di Gessa, Giorgio, Huggins, Charlotte F., Griffith, Gareth J., Kwong, Alex S.F., Bowyer, Ruth, Maddock, Jane, Patalay, Praveetha, Silverwood, Richard J., Fitzsimons, Emla, Shaw, Richard John, Thompson, Ellen J, Steptoe, Andrew, Hughes, Alun, Chaturvedi, Nishi, Steves, Claire J., Katikireddi, Srinivasa Vittal, Ploubidis, George B., Jacques, Wels, Booth, Charlotte, Wielgoszewska, Bożena, Green, Michael J, Di Gessa, Giorgio, Huggins, Charlotte F., Griffith, Gareth J., Kwong, Alex S.F., Bowyer, Ruth, Maddock, Jane, Patalay, Praveetha, Silverwood, Richard J., Fitzsimons, Emla, Shaw, Richard John, Thompson, Ellen J, Steptoe, Andrew, Hughes, Alun, Chaturvedi, Nishi, Steves, Claire J., Katikireddi, Srinivasa Vittal, and Ploubidis, George B.

Abstract

info:eu-repo/semantics/published

Published
2022

41. Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors

Author

Cheetham, Nathan J., primary, Kibble, Milla, additional, Wong, Andrew, additional, Silverwood, Richard J., additional, Knuppel, Anika, additional, Williams, Dylan M., additional, Hamilton, Olivia K. L., additional, Lee, Paul H., additional, Staatz, Charis Bridger, additional, Gessa, Giorgio Di, additional, Zhu, Jingmin, additional, Katikireddi, Srinivasa Vittal, additional, Ploubidis, George B., additional, Thompson, Ellen J., additional, Bowyer, Ruth C. E., additional, Zhang, Xinyuan, additional, Abbasian, Golboo, additional, Garcia, Maria Paz, additional, Hart, Deborah, additional, Seow, Jeffrey, additional, Graham, Carl, additional, Kouphou, Neophytos, additional, Acors, Sam, additional, Malim, Michael H., additional, Mitchell, Ruth E., additional, Northstone, Kate, additional, Major-Smith, Daniel, additional, Matthews, Sarah, additional, Breeze, Thomas, additional, Crawford, Michael, additional, Molloy, Lynn, additional, Kwong, Alex S. F., additional, Doores, Katie J., additional, Chaturvedi, Nishi, additional, Duncan, Emma L., additional, Timpson, Nicholas J., additional, and Steves, Claire J., additional

Published
2022
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42. Mental health outcomes following COVID-19 infection: Evidence from 11 UK longitudinal population studies

Author

Thompson, Ellen J., primary, Stafford, Jean, additional, Moltrecht, Bettina, additional, Huggins, Charlotte F., additional, Kwong, Alex S. F., additional, Shaw, Richard J., additional, Zaninotto, Paola, additional, Patel, Kishan, additional, Silverwood, Richard J., additional, McElroy, Eoin, additional, Pierce, Matthias, additional, Green, Michael J., additional, Bowyer, Ruth C. E., additional, Maddock, Jane, additional, Tilling, Kate, additional, Katikireddi, S. Vittal, additional, Ploubidis, George B., additional, Porteous, David J., additional, Timpson, Nic, additional, Chaturvedi, Nish, additional, Steves, Claire J., additional, and Patalay, Praveetha, additional

Published
2022
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43. Age acquired skewed X Chromosome Inactivation is associated with adverse health outcomes in humans

Author

Roberts, Amy L., primary, Morea, Alessandro, additional, Amar, Ariella, additional, Zito, Antonino, additional, El-Sayed Moustafa, Julia S., additional, Tomlinson, Max, additional, Bowyer, Ruth C. E., additional, Zhang, Xinyuan, additional, Christiansen, Colette, additional, Costeira, Ricardo, additional, Steves, Claire J., additional, Mangino, Massimo, additional, Bell, Jordana T., additional, Wong, Chloe C.Y., additional, Vyse, Timothy J., additional, and Small, Kerrin S., additional

Published
2022
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45. Additional file 4 of Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins

Author

Mesnage, Robin, Bowyer, Ruth C. E., El Balkhi, Souleiman, Saint-Marcoux, Franck, Gardere, Arnaud, Ducarmon, Quinten Raymond, Geelen, Anoecim Robecca, Zwittink, Romy Daniëlle, Tsoukalas, Dimitris, Sarandi, Evangelia, Paramera, Efstathia I., Spector, Timothy, Steves, Claire J., and Antoniou, Michael N.

Subjects
Data_FILES
Abstract

Additional file 4.

Published
2022
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47. Additional file 3 of Characterisation, procedures and heritability of acute dietary intake in the Twins UK cohort: an observational study

Author

Leeming, Emily R., Mompeo, Olatz, Turk, Pauline, Bowyer, Ruth C. E., Louca, Panayiotis, Johnson, Abigail J., Spector, Tim D., Le Roy, Caroline, and Gibson, Rachel

Abstract

Additional file 3: Supplementary Table 2. Two-sided Spearman���s correlation test comparing energy adjusted nutrient output of EFR vs FFQ (n = 1224).

Published
2022
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48. Additional file 2 of Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins

Author

Mesnage, Robin, Bowyer, Ruth C. E., El Balkhi, Souleiman, Saint-Marcoux, Franck, Gardere, Arnaud, Ducarmon, Quinten Raymond, Geelen, Anoecim Robecca, Zwittink, Romy Daniëlle, Tsoukalas, Dimitris, Sarandi, Evangelia, Paramera, Efstathia I., Spector, Timothy, Steves, Claire J., and Antoniou, Michael N.

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2022
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50. Incremental Value of a Panel of Serum Metabolites for Predicting Risk of Atherosclerotic Cardiovascular Disease

Author

Nogal, Ana, primary, Louca, Panayiotis, additional, Tran, Tran Quoc Bao, additional, Bowyer, Ruth C., additional, Christofidou, Paraskevi, additional, Steves, Claire J., additional, Berry, Sarah E., additional, Wong, Kari, additional, Wolf, Jonathan, additional, Franks, Paul W., additional, Mangino, Massimo, additional, Spector, Tim D., additional, Valdes, Ana M., additional, Padmanabhan, Sandosh, additional, and Menni, Cristina, additional

Published
2022
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