133 results on '"Bowo-Ngandji, A."'
Search Results
2. Global epidemiology of hepatitis C virus in dialysis patients: A systematic review and meta-analysis.
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Raoul Kenfack-Momo, Marceline Djuidje Ngounoue, Sebastien Kenmoe, Guy Roussel Takuissu, Jean Thierry Ebogo-Belobo, Cyprien Kengne-Ndé, Donatien Serge Mbaga, Elisabeth Zeuko'o Menkem, Robertine Lontuo Fogang, Serges Tchatchouang, Juliette Laure Ndzie Ondigui, Ginette Irma Kame-Ngasse, Josiane Kenfack-Zanguim, Jeannette Nina Magoudjou-Pekam, Arnol Bowo-Ngandji, Maimouna Mahamat, Seraphine Nkie Esemu, Lucy Ndip, and Richard Njouom
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Medicine ,Science - Abstract
Dialysis is a replacement therapy for patients with End-Stage Renal Disease (ESRD). Patients on dialysis are at high risk of acquiring hepatitis C virus (HCV), which has become a leading cause of morbidity and mortality in this population. There is a wide range of prevalence of HCV in dialysis populations around the world. It is still unknown how prevalent HCV infection is among worldwide dialysis patients (including those undergoing hemodialysis and peritoneal dialysis). A review was conducted to estimate the global epidemiology of hepatitis C in dialysis patients. We searched PubMed, Excerpta Medica Database (Embase), Global Index Medicus and Web of Science until October 2022. A manual search of references from relevant articles was also conducted. Heterogeneity was evaluated by the χ2 test on Cochrane's Q statistic, and the sources of heterogeneity were investigated using subgroup analysis. In order to assess publication bias, funnel plots and Egger tests were conducted, and pooled HCV prevalence estimates were generated using a DerSimonian and Laird meta-analysis model. The study is registered with PROSPERO under CRD42022237789. We included 634 papers involving 392160 participants. The overall HCV case fatality rate was 38.7% (95% CI = 28.9-49). The global prevalence of HCV infection in dialysis population group were 24.3% [95% CI = 22.6-25.9]. As indicated by UNSD region, country, dialysis type, and HCV diagnostic targeted; Eastern Europe had the highest prevalence of 48.6% [95% CI = 35.2-62], Indonesia had 63.6% [95% CI = 42.9-82], hemodialysis patients had 25.5% [95% CI = 23.8-27.3], and anti-HCV were detected in 24.5% [95% CI = 22.8-26.2]. Dialysis patients, particularly those on hemodialysis, have a high prevalence and case fatality rate of HCV infection. Hemodialysis units need to implement strict infection control measures.
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- 2024
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3. A systematic review of influenza virus in water environments across human, poultry, and wild bird habitats
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S Kenmoe, GR Takuissu, JT Ebogo-Belobo, C Kengne-Ndé, DS Mbaga, A Bowo-Ngandji, JL Ondigui Ndzie, R Kenfack-Momo, S Tchatchouang, R Lontuo Fogang, E Zeuko'o Menkem, GI Kame-Ngasse, JN Magoudjou-Pekam, S Puzelli, L Lucentini, C Veneri, P Mancini, G Bonanno Ferraro, M Iaconelli, C Del Giudice, D Brandtner, E Suffredini, and G La Rosa
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Influenza virus ,Water ,Prevalence ,Occurrence ,Environmental technology. Sanitary engineering ,TD1-1066 - Abstract
Influenza, a highly contagious acute respiratory disease, remains a major global health concern. This study aimed to comprehensively assess the prevalence of influenza virus in different aquatic environments.Using 43 articles from four databases, we thoroughly examined water matrices from wastewater treatment plants (WTPs) and other human environments, as well as poultry habitats and areas frequented by migratory wild birds.In WTP influents (10 studies), positivity rates for influenza A ranged from 0.0 % to 97.6 %. For influenza B (8 studies), most studies reported no positivity, except for three studies reporting detection in 0.8 %, 5.6 %, and 46.9 % of samples. Within poultry habitats (13 studies), the prevalence of influenza A ranged from 4.3 % to 76.4 %, while in environments frequented by migratory wild birds (11 studies), it ranged from 0.4 % to 69.8 %. Geographically, the studies were distributed as follows: 39.5 % from the Americas, 18.6 % from Europe, 2.3 % from South-East Asia and 39.5 % from the Western Pacific.Several influenza A subtypes were found in water matrices, including avian influenza (H3N6, H3N8, H4N1, H4N2, H4N6, H4N8, H5N1, H5N8, H6N2, H6N6, H7N9, H0N8, and H11N9) and seasonal human influenza (H1N1 and H3N2). The existing literature indicates a crucial requirement for more extensive future research on this topic. Specifically, it emphasizes the need for method harmonization and delves into areas deserving of in-depth research, such as water matrices pertaining to pig farming and prevalence studies in low-income countries.
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- 2024
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4. Contemporary epidemiological data of Rift Valley fever virus in humans, mosquitoes and other animal species in Africa: A systematic review and meta‐analysis
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Jean Thierry Ebogo‐Belobo, Sebastien Kenmoe, Ngu Njei Abanda, Arnol Bowo‐Ngandji, Donatien Serge Mbaga, Jeannette Nina Magoudjou‐Pekam, Ginette Irma Kame‐Ngasse, Serges Tchatchouang, Elisabeth Zeuko'o Menkem, Etienne Atenguena Okobalemba, Efietngab Atembeh Noura, Dowbiss Meta‐Djomsi, Martin Maïdadi‐Foudi, Josiane Kenfack‐Zanguim, Raoul Kenfack‐Momo, Cyprien Kengne‐Nde, Seraphine Nkie Esemu, Wilfred Fon Mbacham, Serge Alain Sadeuh‐Mba, Lucy Ndip, and Richard Njouom
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Africa ,animals ,humans ,mosquitoes ,Rift Valley fever virus ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Rift Valley fever (RVF) is a severe zoonotic mosquito‐borne disease that represents an important threat to human and animal health, with major public health and socioeconomic impacts. This disease is endemic throughout many African countries and the Arabian Peninsula. This systematic review with meta‐analysis was conducted to determine the RVF prevalence in humans, mosquitoes and other animal species in Africa. The review also provides contemporary data on RVF case fatality rate (CFR) in humans. In this systematic review with meta‐analysis, a comprehensive literature search was conducted on the PubMed, Embase, Web of Science and Global Index Medicus databases from January 2000 to June 2022 to identify relevant studies. Pooled CFR and prevalence estimates were calculated using the random‐effects model. Subgroup analysis and sensitivity analysis were performed, and the I2‐statistic was used to investigate a potential source of heterogeneity. A total of 205 articles were included in the final analysis. The overall RVF CFR in humans was found to be 27.5% [95% CI = 8.0–52.5]. The overall pooled prevalence was 7.8% [95% CI = 6.2–9.6] in humans and 9.3% [95% CI = 8.1–10.6] in animals, respectively. The RVF prevalence in individual mosquitoes ranged from 0.0% to 25%. Subgroup analysis showed substantial heterogeneity with respect to geographical regions and human categories. The study shows that there is a correspondingly similar prevalence of RVF in human and animals; however, human CFR is much higher than the observed prevalence. The lack of a surveillance programme and the fact that this virus has subclinical circulation in animals and humans could explain these observations. The implementation of a One Health approach for RVF surveillance and control would be of great interest for human and animal health.
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- 2023
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5. A systematic review of influenza virus in water environments across human, poultry, and wild bird habitats
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Kenmoe, S, Takuissu, GR, Ebogo-Belobo, JT, Kengne-Ndé, C, Mbaga, DS, Bowo-Ngandji, A, Ondigui Ndzie, JL, Kenfack-Momo, R, Tchatchouang, S, Lontuo Fogang, R, Zeuko'o Menkem, E, Kame-Ngasse, GI, Magoudjou-Pekam, JN, Puzelli, S, Lucentini, L, Veneri, C, Mancini, P, Bonanno Ferraro, G, Iaconelli, M, Del Giudice, C, Brandtner, D, Suffredini, E, and La Rosa, G
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- 2024
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6. A State-of-the-Art Scoping Review on SARS-CoV-2 in Sewage Focusing on the Potential of Wastewater Surveillance for the Monitoring of the COVID-19 Pandemic
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Bonanno Ferraro, G., Veneri, C., Mancini, P., Iaconelli, M., Suffredini, E., Bonadonna, L., Lucentini, L., Bowo-Ngandji, A., Kengne-Nde, C., Mbaga, D. S., Mahamat, G., Tazokong, H. R., Ebogo-Belobo, J. T., Njouom, R., Kenmoe, S., and La Rosa, G.
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- 2022
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7. Epidemiology of occult hepatitis B and C in Africa: A systematic review and meta-analysis
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Juliette Laure Ndzie Ondigui, Sebastien Kenmoe, Cyprien Kengne-Ndé, Jean Thierry Ebogo-Belobo, Guy Roussel Takuissu, Raoul Kenfack-Momo, Donatien Serge Mbaga, Serges Tchatchouang, Josiane Kenfack-Zanguim, Robertine Lontuo Fogang, Elisabeth Zeuko'o Menkem, Ginette Irma Kame-Ngasse, Jeannette Nina Magoudjou-Pekam, Arnol Bowo-Ngandji, Nadège Mafopa Goumkwa, Seraphine Nkie Esemu, Lucy Ndip, Sara Honorine Riwom Essama, and Judith Torimiro
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Occult hepatitis B ,Occult hepatitis C ,Prevalence ,Africa ,Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Occult hepatitis B (OBI) and C (OCI) infections lead to hepatic crises including cases of liver cirrhosis and even hepatocellular carcinoma (HCC). OBI and OCI also pose a significant problem of their transmissibility. This study aimed to assess the overall prevalence of OBI and OCI in the African continent, a region highly endemic for classical hepatitis B and C viruses. Methods: For this systematic review and meta-analysis, we searched: PubMed, Web of Science, African Journal Online and African Index Medicus for published studies on the prevalence of OBI and OCI in Africa. Study selection and data extraction were performed by at least two independent investigators. Heterogeneity (I²) was assessed using the χ² test on the Cochran Q statistic and H parameters. Sources of heterogeneity were explored by subgroup analyses. This study was registered in PROSPERO, with reference number CRD42021252772. Results: We obtained 157 prevalence data for this meta-analysis, from 134 studies for OBI prevalence; 23 studies on OCI prevalence, and a single study on the OBI case fatality rate. The overall estimate for the prevalence of OBI was 14.8% [95% CI = 12.2–17.7] among 18579 participants. The prevalence of seronegative OBI and seropositive OBI was 7.4% [95% CI = 3.8–11.8] and 20.0% [95% CI = 15.3–25.1] respectively. The overall estimate for the prevalence of OCI was 10.7% [95% CI = 6.6–15.4] among 2865 participants. The pooled prevalence of seronegative OCI was estimated at 10.7% [95%CI = 4.8–18.3] and that of seropositive OCI at 14.4% [95%CI = 5.2–22.1]. In Sub-group analysis, patients with malignancies, chronic hepatitis C, and hemodialysis had a higher OCI prevalence. While those with malignancies, liver disorders, and HIV positive registered highest OBI prevalence. Conclusion: This review shows a high prevalence of OBI and OCI in Africa, with variable prevalence between countries and population groups.
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- 2022
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8. Systematic review and meta-analysis of maternal and fetal outcomes among pregnant women with bacterial vaginosis
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Kenfack-Zanguim, Josiane, Kenmoe, Sebastien, Bowo-Ngandji, Arnol, Kenfack-Momo, Raoul, Thierry Ebogo-Belobo, Jean, Kengne-Ndé, Cyprien, Serge Mbaga, Donatien, Zeuko'o Menkem, Elisabeth, Lontuo Fogang, Robertine, Tchatchouang, Serges, Laure Ndzie Ondigui, Juliette, Irma Kame-Ngasse, Ginette, Nina Magoudjou-Pekam, Jeannette, Roussel Takuissu, Guy, Nkie Esemu, Seraphine, Nantcho Clavela, Nguepgjio, Barriere Fodjo, Airy, Ndip, Lucy, Bigoga, Jude, Megnekou, Rosette, and Esemu, Livo F.
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- 2023
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9. Hepatitis E Virus in Water Environments: A Systematic Review and Meta-analysis
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Takuissu, G. R., Kenmoe, S., Ndip, L., Ebogo-Belobo, J. T., Kengne-Ndé, C., Mbaga, D. S., Bowo-Ngandji, A., Oyono, M. G., Kenfack-Momo, R., Tchatchouang, S., Kenfack-Zanguim, J., Lontuo Fogang, R., Zeuko’o Menkem, E., Kame-Ngasse, G. I., Magoudjou-Pekam, J. N., Nkie Esemu, S., Veneri, C., Mancini, P., Bonanno Ferraro, G., Iaconelli, M., Suffredini, E., and La Rosa, G.
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- 2022
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10. Epidemiology of occult hepatitis B and C in Africa: A systematic review and meta-analysis
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Ondigui, Juliette Laure Ndzie, Kenmoe, Sebastien, Kengne-Ndé, Cyprien, Ebogo-Belobo, Jean Thierry, Takuissu, Guy Roussel, Kenfack-Momo, Raoul, Mbaga, Donatien Serge, Tchatchouang, Serges, Kenfack-Zanguim, Josiane, Fogang, Robertine Lontuo, Menkem, Elisabeth Zeuko'o, Kame-Ngasse, Ginette Irma, Magoudjou-Pekam, Jeannette Nina, Bowo-Ngandji, Arnol, Goumkwa, Nadège Mafopa, Esemu, Seraphine Nkie, Ndip, Lucy, Essama, Sara Honorine Riwom, and Torimiro, Judith
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- 2022
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11. A mapping review of methicillin-resistant Staphylococcus aureus proportions, genetic diversity, and antimicrobial resistance patterns in Cameroon.
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Nene Kaah Keneh, Sebastien Kenmoe, Arnol Bowo-Ngandji, Jane-Francis Tatah Kihla Akoachere, Hortense Gonsu Kamga, Roland Ndip Ndip, Jean Thierry Ebogo-Belobo, Cyprien Kengne-Ndé, Donatien Serge Mbaga, Nicholas Tendongfor, Lucy Mande Ndip, and Seraphine Nkie Esemu
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Medicine ,Science - Abstract
BackgroundThe emergence of methicillin-resistant Staphylococcus aureus (MRSA) has increased and poses a significant threat to human and animal health in Cameroon and the world at large. MRSA strains have infiltrated various settings, including hospitals, communities, and livestock, contributing to increased morbidity, treatment costs, and mortality. This evidence synthesis aims to understand MRSA prevalence, resistance patterns, and genetic characterization in Cameroon.MethodsThe methodology was consistent with the PRISMA 2020 guidelines. Studies of any design containing scientific data on MRSA prevalence, genetic diversity, and antimicrobial resistance patterns in Cameroon were eligible for inclusion, with no restrictions on language or publication date. The search involved a comprehensive search strategy in several databases including Medline, Embase, Global Health, Web of Science, African Index Medicus, and African Journal Online. The risk of bias in the included studies was assessed using the Hoy et al tool, and the results were synthesized and presented in narrative synthesis and/or tables and graphs.ResultsThe systematic review analyzed 24 studies, mostly conducted after 2010, in various settings in Cameroon. The studies, characterized by moderate to low bias, revealed a wide prevalence of MRSA ranging from 1.9% to 46.8%, with considerable variation based on demographic and environmental factors. Animal (0.2%), food (3.2% to 15.4%), and environmental samples (0.0% to 34.6%) also showed a varied prevalence of MRSA. The genetic diversity of MRSA was heterogeneous, with different virulence gene profiles and clonal lineages identified in various populations and sample types. Antimicrobial resistance rates showed great variability in the different regions of Cameroon, with notable antibiotic resistance recorded for the beta-lactam, fluoroquinolone, glycopeptide, lincosamide, and macrolide families.ConclusionThis study highlights the significant variability in MRSA prevalence, genetic diversity, and antimicrobial resistance patterns in Cameroon, and emphasizes the pressing need for comprehensive antimicrobial stewardship strategies in the country.
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- 2023
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12. Epidemiology of carbapenem-resistant Acinetobacter baumannii colonization in neonatal intensive care units: A systematic review and meta-analysis
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Mbaga, Donatien Serge, primary, Kenmoe, Sebastien, additional, Esemu, Seraphine Nkie, additional, Bowo-Ngandji, Arnol, additional, Keneh, Nene Kaah, additional, Tatah Kihla Akoachere, Jane-Francis, additional, Gonsu, Hortense Kamga, additional, Ndip Ndip, Roland, additional, Ebogo-Belobo, Jean Thierry, additional, Kengne-Ndé, Cyprien, additional, Tendongfor, Nicholas, additional, Assam Assam, Jean Paul, additional, Ndip, Lucy Mande, additional, Njiki Bikoï, Jacky, additional, and Riwom Essama, Sara Honorine, additional
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- 2024
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13. Global epidemiology of hepatitis C virus in dialysis patients: A systematic review and meta-analysis
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Kenfack-Momo, Raoul, primary, Ngounoue, Marceline Djuidje, additional, Kenmoe, Sebastien, additional, Takuissu, Guy Roussel, additional, Ebogo-Belobo, Jean Thierry, additional, Kengne-Ndé, Cyprien, additional, Mbaga, Donatien Serge, additional, Zeuko’o Menkem, Elisabeth, additional, Lontuo Fogang, Robertine, additional, Tchatchouang, Serges, additional, Ndzie Ondigui, Juliette Laure, additional, Kame-Ngasse, Ginette Irma, additional, Kenfack-Zanguim, Josiane, additional, Magoudjou-Pekam, Jeannette Nina, additional, Bowo-Ngandji, Arnol, additional, Mahamat, Maimouna, additional, Nkie Esemu, Seraphine, additional, Ndip, Lucy, additional, and Njouom, Richard, additional
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- 2024
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14. Epidemiology of yellow fever virus in humans, arthropods, and non-human primates in sub-Saharan Africa: A systematic review and meta-analysis.
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Martin Gael Oyono, Sebastien Kenmoe, Ngu Njei Abanda, Guy Roussel Takuissu, Jean Thierry Ebogo-Belobo, Raoul Kenfack-Momo, Cyprien Kengne-Nde, Donatien Serge Mbaga, Serges Tchatchouang, Josiane Kenfack-Zanguim, Robertine Lontuo Fogang, Elisabeth Zeuko'o Menkem, Juliette Laure Ndzie Ondigui, Ginette Irma Kame-Ngasse, Jeannette Nina Magoudjou-Pekam, Arnol Bowo-Ngandji, Seraphine Nkie Esemu, and Lucy Ndip
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
Yellow fever (YF) has re-emerged in the last two decades causing several outbreaks in endemic countries and spreading to new receptive regions. This changing epidemiology of YF creates new challenges for global public health efforts. Yellow fever is caused by the yellow fever virus (YFV) that circulates between humans, the mosquito vector, and non-human primates (NHP). In this systematic review and meta-analysis, we review and analyse data on the case fatality rate (CFR) and prevalence of YFV in humans, and on the prevalence of YFV in arthropods, and NHP in sub-Saharan Africa (SSA). We performed a comprehensive literature search in PubMed, Web of Science, African Journal Online, and African Index Medicus databases. We included studies reporting data on the CFR and/or prevalence of YFV. Extracted data was verified and analysed using the random effect meta-analysis. We conducted subgroup, sensitivity analysis, and publication bias analyses using the random effect meta-analysis while I2 statistic was employed to determine heterogeneity. This review was registered with PROSPERO under the identification CRD42021242444. The final meta-analysis included 55 studies. The overall case fatality rate due to YFV was 31.1% (18.3-45.4) in humans and pooled prevalence of YFV infection was 9.4% (6.9-12.2) in humans. Only five studies in West and East Africa detected the YFV in mosquito species of the genus Aedes and in Anopheles funestus. In NHP, YFV antibodies were found only in members of the Cercopithecidae family. Our analysis provides evidence on the ongoing circulation of the YFV in humans, Aedes mosquitoes and NHP in SSA. These observations highlight the ongoing transmission of the YFV and its potential to cause large outbreaks in SSA. As such, strategies such as those proposed by the WHO's Eliminate Yellow Fever Epidemics (EYE) initiative are urgently needed to control and prevent yellow fever outbreaks in SSA.
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- 2022
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15. Exploring adenovirus in water environments: a systematic review and meta-analysis.
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Takuissu, G. R., Kenmoe, S., Ebogo-Belobo, J. T., Kengne-Ndé, C., Mbaga, D. S., Bowo-Ngandji, A., Ondigui Ndzie, J. L., Kenfack-Momo, R., Tchatchouang, S., Kenfack-Zanguim, J., Lontuo Fogang, R., Zeuko'o Menkem, E., Kame-Ngasse, G. I., Magoudjou-Pekam, J. N., Suffredini, E., Veneri, C., Mancini, P., Bonanno Ferraro, G., Iaconelli, M., and Verani, M.
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ENVIRONMENTAL health ,RISK assessment ,NATURE ,ADENOVIRUSES ,DEVELOPED countries ,AQUATIC microbiology ,META-analysis ,DESCRIPTIVE statistics ,SYSTEMATIC reviews ,WATER pollution ,WATER ,DEVELOPING countries ,VIRUS diseases ,SEWAGE ,DISEASE risk factors - Abstract
Adenoviruses (AdVs) have a significant impact in both medical and environmental contexts. The objective of this study was to investigate the prevalence of AdV in different water types, such as untreated and treated wastewater, surface water, groundwater, drinking water, and other water matrices. A total of 239 articles were included in this meta-analysis. Adenoviruses were detected in various waters worldwide. The overall prevalence in water was found to be 59.2%, with the highest prevalence in untreated wastewater (83.1%) and treated wastewater (75.3%), followed by "other water matrices" (53.4%), surface water (49.5%) drinking water (22.7%), and groundwater (18.5%). Most of the studies did not assess the viability of the viruses, leading to weak links between water contamination and risk. Both human and animal AdV were found in water environments. The findings suggest that water, including drinking water, could be a significant route of AdV transmission in both developed and developing economies. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Epidemiology of Rotavirus in Humans, Animals, and the Environment in Africa: A Systematic Review and Meta-analysis.
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Njifon, Hermann Landry Munshili, Kenmoe, Sebastien, Ahmed, Sharia M, Takuissu, Guy Roussel, Ebogo-Belobo, Jean Thierry, Njile, Daniel Kamga, Bowo-Ngandji, Arnol, Mbaga, Donatien Serge, Kengne-Nde, Cyprien, Mouiche, Mohamed Moctar Mouliom, Njouom, Richard, Perraut, Ronald, and Leung, Daniel T
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ROTAVIRUSES ,ROTAVIRUS diseases ,EPIDEMIOLOGY ,INFECTIOUS disease transmission ,DEATH rate ,CHILD death ,ECOLOGY - Abstract
Background Globally, rotavirus infections are the most common cause of diarrhea-related deaths, especially among children under 5 years of age. This virus can be transmitted through the fecal-oral route, although zoonotic and environmental contributions to transmission are poorly defined. The purpose of this study is to determine the epidemiology of rotavirus in humans, animals, and the environment in Africa, as well as the impact of vaccination. Methods We searched PubMed, Web of Science, Africa Index Medicus, and African Journal Online, identifying 240 prevalence data points from 224 articles between 2009 and 2022. Results Human rotavirus prevalence among patients with gastroenteritis was 29.8% (95% confidence interval [CI], 28.1%–31.5%; 238 710 participants), with similar estimates in children under 5 years of age, and an estimated case fatality rate of 1.2% (95% CI,.7%–2.0%; 10 440 participants). Prevalence was estimated to be 15.4% and 6.1% in patients with nongastroenteritis illnesses and apparently healthy individuals, respectively. Among animals, prevalence was 9.3% (95% CI, 5.7%–13.7%; 6115 animals), and in the environmental water sources, prevalence was 31.4% (95% CI, 17.7%–46.9%; 2530 samples). Discussion Our findings highlight the significant burden of rotavirus infection in Africa, and underscore the need for a One Health approach to limiting the spread of this disease. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Methicillin-Resistant Staphylococcus aureus Carriage among Neonate Mothers, Healthcare Workers, and Environmental Samples in Neonatal Intensive Care Units: A Systematic Review.
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Keneh, Nene Kaah, Kenmoe, Sebastien, Bowo-Ngandji, Arnol, Akoachere, Jane-Francis Tatah Kihla, Kamga, Hortense Gonsu, Ndip, Roland Ndip, Ebogo-Belobo, Jean Thierry, Kengne-Ndé, Cyprien, Mbaga, Donatien Serge, Tendongfor, Nicholas, Assam, Jean Paul Assam, Ndip, Lucy Mande, and Esemu, Seraphine Nkie
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MEDICAL information storage & retrieval systems ,CROSS infection ,NEONATAL intensive care units ,SCIENTIFIC observation ,METHICILLIN-resistant staphylococcus aureus ,NEONATAL intensive care ,SYSTEMATIC reviews ,MEDLINE ,STERILIZATION (Disinfection) ,PSYCHOLOGY of mothers ,POLLUTANTS ,INFECTIOUS disease transmission ,CONFIDENCE intervals - Abstract
Background. Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of morbidity and mortality among neonates admitted to neonatal intensive care units (NICUs). The MRSA colonization of neonates, attributed to various sources, including mothers, healthcare workers, and environmental surfaces, can lead to severe infection, prolonged hospital stays, and even death, imposing substantial economic burdens. Given the pressing need to mitigate MRSA spread in these vulnerable environments, further examination of the subject is warranted. This systematic review is aimed at synthesizing available evidence on MRSA carriage proportions among mothers of newborns, healthcare workers, and environmental surfaces in NICUs. Methodology. We included observational studies published in English or French from database inception to March 21, 2023. These studies focused on MRSA in nonoutbreak NICU settings, encompassing healthy neonate mothers and healthcare workers, and environmental surfaces. Literature search involved systematic scanning of databases, including Medline, Embase, Web of Science, Global Health, and Global Index Medicus. The quality of the selected studies was assessed using the Hoy et al. critical appraisal scale. The extracted data were summarized to calculate the pooled proportion of MRSA positives, with a 95% confidence interval (CI) based on the DerSimonian and Laird random-effects model. Results. A total of 1891 articles were retrieved from which 16 studies were selected for inclusion. Most of the studies were from high-income countries. The pooled proportion of MRSA carriage among 821 neonate mothers across four countries was found to be 2.1% (95% CI: 0.3-5.1; I 2 = 76.6 %, 95% CI: 36.1-91.5). The proportion of MRSA carriage among 909 HCWs in eight countries was determined to be 9.5% (95% CI: 3.1-18.4; I 2 = 91.7 %, 95% CI: 87.1-94.6). The proportion of MRSA carriage among HCWs was highest in the Western Pacific Region, at 50.00% (95% CI: 23.71-76.29). In environmental specimens from five countries, a pooled proportion of 16.6% (95% CI: 3.5-36.0; I 2 = 97.7 %, 95% CI: 96.6-98.4) was found to be MRSA-positive. Conclusion. With a significant heterogeneity, our systematic review found high MRSA carriage rates in neonate mothers, healthcare workers, and across various environmental surfaces in NICUs, posing a potential risk of nosocomial infections. Urgent interventions, including regular screening and decolonization of MRSA carriers, reinforcing infection control measures, and enhancing cleaning and disinfection procedures within NICUs, are crucial. This trial is registered with CRD42023407114. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis
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Amary Fall, Sebastien Kenmoe, Jean Thierry Ebogo-Belobo, Donatien Serge Mbaga, Arnol Bowo-Ngandji, Joseph Rodrigue Foe-Essomba, Serges Tchatchouang, Marie Amougou Atsama, Jacqueline Félicité Yéngué, Raoul Kenfack-Momo, Alfloditte Flore Feudjio, Alex Durand Nka, Chris Andre Mbongue Mikangue, Jean Bosco Taya-Fokou, Jeannette Nina Magoudjou-Pekam, Efietngab Atembeh Noura, Cromwel Zemnou-Tepap, Dowbiss Meta-Djomsi, Martin Maïdadi-Foudi, Ginette Irma Kame-Ngasse, Inès Nyebe, Larissa Gertrude Djukouo, Landry Kengne Gounmadje, Dimitri Tchami Ngongang, Martin Gael Oyono, Cynthia Paola Demeni Emoh, Hervé Raoul Tazokong, Gadji Mahamat, Cyprien Kengne-Ndé, Serge Alain Sadeuh-Mba, Ndongo Dia, Giuseppina La Rosa, Lucy Ndip, and Richard Njouom
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
A substantial amount of epidemiological data has been reported on Enterovirus D68 (EV-D68) infections after the 2014 outbreak. Our goal was to map the case fatality rate (CFR) and prevalence of current and past EV-D68 infections. We conducted a systematic review (PROSPERO, CRD42021229255) with published articles on EV-68 infections in PubMed, Embase, Web of Science and Global Index Medicus up to January 2021. We determined prevalences using a model random effect. Of the 4,329 articles retrieved from the databases, 89 studies that met the inclusion criteria were from 39 different countries with apparently healthy individuals and patients with acute respiratory infections, acute flaccid myelitis and asthma-related diseases. The CFR estimate revealed occasional deaths (7/1353) related to EV-D68 infections in patients with severe acute respiratory infections. Analyses showed that the combined prevalence of current and past EV-D68 infections was 4% (95% CI = 3.1–5.0) and 66.3% (95% CI = 40.0–88.2), respectively. The highest prevalences were in hospital outbreaks, developed countries, children under 5, after 2014, and in patients with acute flaccid myelitis and asthma-related diseases. The present study shows sporadic deaths linked to severe respiratory EV-D68 infections. The study also highlights a low prevalence of current EV-D68 infections as opposed to the existence of EV-D68 antibodies in almost all participants of the included studies. These findings therefore highlight the need to implement and/or strengthen continuous surveillance of EV-D68 infections in hospitals and in the community for the anticipation of the response to future epidemics. Author summary Enterovirus D68 (EV-D68) infections represent a global public health concern. EV-D68 are detected in apparently healthy subjects and patients with acute respiratory illnesses, acute flaccid myelitis, and asthma-related illnesses. Enterovirus D68 was first described in 1962 and exhibited sporadic circulation until August 2014 when outbreaks of EV-D68 infections were reported in the USA and Canada mainly in children with acute flaccid myelitis and severe acute respiratory disease. We systematically reviewed the literature on EV-D68 infections globally in the present study to determine the case fatality rate and prevalence of current and past infections. Our results show sporadic deaths in patients with severe acute respiratory EV-D68 infections. Our data also show a low prevalence of EV-D68 in current infections unlike the presence of EV-D68 antibodies (past infections) in almost all individuals of all ages. EV-D68 infections were more prevalent in hospital outbreaks, industrialized countries, children < 5 years, and patients with acute flaccid myelitis and asthma-related diseases. These data highlight the need to strengthen the surveillance of EV-D68 infections.
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- 2022
19. Epidemiology of hepatitis B virus and/or hepatitis C virus infections among people living with human immunodeficiency virus in Africa: A systematic review and meta-analysis
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Raoul Kenfack-Momo, Sebastien Kenmoe, Guy Roussel Takuissu, Jean Thierry Ebogo-Belobo, Cyprien Kengne-Ndé, Donatien Serge Mbaga, Serges Tchatchouang, Martin Gael Oyono, Josiane Kenfack-Zanguim, Robertine Lontuo Fogang, Chris Andre Mbongue Mikangue, Elisabeth Zeuko’o Menkem, Juliette Laure Ndzie Ondigui, Ginette Irma Kame-Ngasse, Jeannette Nina Magoudjou-Pekam, Jean Bosco Taya-Fokou, Arnol Bowo-Ngandji, Seraphine Nkie Esemu, Diane Kamdem Thiomo, Paul Moundipa Fewou, Lucy Ndip, and Richard Njouom
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Medicine ,Science - Abstract
Introduction Due to their common routes of transmission, human immunodeficiency virus (HIV) coinfection with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) has become a major public health problem worldwide, particularly in Africa, where these viruses are endemic. Few systematic reviews report the epidemiological data of HBV and/or HCV coinfection with HIV in Africa, and none provided data on the case fatality rate (CFR) associated with this coinfection. This study was conducted to investigate the prevalence and case fatality rate of HBV and/or HCV infections among people living with human immunodeficiency virus (PLHIV) in Africa. Methods We conducted a systematic review of published articles in PubMed, Web of Science, African Journal Online, and African Index Medicus up to January 2022. Manual searches of references from retrieved articles and grey literature were also performed. The meta-analysis was performed using a random-effects model. Sources of heterogeneity were investigated using subgroup analysis, while funnel plots and Egger tests were performed to assess publication bias. Results Of the 4388 articles retrieved from the databases, 314 studies met all the inclusion criteria. The overall HBV case fatality rate estimate was 4.4% (95% CI; 0.7–10.3). The overall seroprevalences of HBV infection, HCV infection, and HBV/HCV coinfection in PLHIV were 10.5% [95% CI = 9.6–11.3], 5.4% [95% CI = 4.6–6.2], and 0.7% [95% CI = 0.3–1.0], respectively. The pooled seroprevalences of current HBsAg, current HBeAg, and acute HBV infection among PLHIV were 10.7% [95% CI = 9.8–11.6], 7.0% [95% CI = 4.7–9.7], and 3.6% [95% CI = 0.0–11.0], respectively. Based on HBV-DNA and HCV-RNA detection, the seroprevalences of HBV and HCV infection in PLHIV were 17.1% [95% CI = 11.5–23.7] and 2.5% [95% CI = 0.9–4.6], respectively. Subgroup analysis showed substantial heterogeneity. Conclusions In Africa, the prevalence of hepatotropic viruses, particularly HBV and HCV, is high in PLHIV, which increases the case fatality rate. African public health programs should emphasize the need to apply and comply with WHO guidelines on viral hepatitis screening and treatment in HIV-coinfected patients. Review registration PROSPERO, CRD42021237795.
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- 2022
20. Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders
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Donatien Serge Mbaga, Sebastien Kenmoe, Cyprien Kengne-Ndé, Jean Thierry Ebogo-Belobo, Gadji Mahamat, Joseph Rodrigue Foe-Essomba, Marie Amougou-Atsama, Serges Tchatchouang, Inès Nyebe, Alfloditte Flore Feudjio, Ginette Irma Kame-Ngasse, Jeannette Nina Magoudjou-Pekam, Lorraine K. M. Fokou, Dowbiss Meta-Djomsi, Martin Maïdadi-Foudi, Sabine Aimee Touangnou-Chamda, Audrey Gaelle Daha-Tchoffo, Abdel Aziz Selly-Ngaloumo, Rachel Audrey Nayang-Mundo, Jacqueline Félicité Yéngué, Jean Bosco Taya-Fokou, Raoul Kenfack-Momo, Efietngab Atembeh Noura, Cynthia Paola Demeni Emoh, Hervé Raoul Tazokong, Arnol Bowo-Ngandji, Carole Stéphanie Sake, Etienne Atenguena Okobalemba, Jacky Njiki Bikoi, Richard Njouom, and Sara Honorine Riwom Essama
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Medicine ,Science - Abstract
Introduction Africa denotes unique facies for hepatocellular carcinoma (HCC) characterized by a conjunction of low sensitization, restricted access to diagnosis and treatment and associated with the highest incidence and mortality in the world. We investigated whether hepatitis B (HBV), C (HCV) and D (VHD) viruses were etiological agents of HCC in Africa. Methods Relevant articles were searched in PubMed, Web of Science, African Index Medicus, and African Journal Online databases, as well as manual searches in relevant reviews and included articles. Analytical studies from Africa evaluating the association between HCC development and HBV, HCV, and HDV were included. Relevant studies were selected, data extracted, and the risk of bias assessed independently by at least 2 investigators. The association was estimated using odds ratios (OR) and their 95% confidence interval (95% CI) determined by a random-effects model. Sources of heterogeneity were determined by subgroup analyses. Results A total of 36 case-control studies were included. With controls having non-hepatic disease, the overall results suggested a significantly increased risk of HCC in patients with HBV (HBeAg (OR = 19.9; 95% CI = [3.7–105.2]), HBsAg (OR = 9.9; 95%) CI = [6.2–15.6]) and DNA (OR = 8.9; 95% CI = [5.9–13.4]); HCV (Anti-HCV (OR = 9.4; 95% CI = [6.3–14.0]) and RNA (OR = 16.5; 95% CI = [7.8–34.6]); HDV (Anti-VHD, (OR = 25.8; 95% CI = [5.9–112.2]); and HBV/HCV coinfections (HBV DNA/HCV RNA (OR = 22.5; 95% CI = [1.3–387.8]). With apparently healthy controls, the overall results suggested a significantly increased risk of HCC in patients with HBV (HBsAg, (OR = 8.9; 95% CI = [6.0–13.0]); HCV (Anti-HCV, (OR = 7.7; 95% CI = [5.6–10.6]); and HBV/HCV coinfections (HBsAg/Anti-HCV (OR = 7.8; 95% CI = [4.4–13.6]) Substantial heterogeneity and the absence of publication bias were recorded for these results. Conclusions In Africa, HBV/HCV coinfections and HBV, HCV, and HDV infections are associated with an increased risk of developing HCC. The implementation of large-scale longitudinal and prospective studies including healthy participants to search for early biomarkers of the risk of progression to HCC is urgently needed.
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- 2022
21. Global epidemiology of occult hepatitis B virus infections in blood donors, a systematic review and meta-analysis
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Guy Roussel Takuissu, Sebastien Kenmoe, Marie Amougou Atsama, Etienne Atenguena Okobalemba, Donatien Serge Mbaga, Jean Thierry Ebogo-Belobo, Arnol Bowo-Ngandji, Martin Gael Oyono, Jeannette Nina Magoudjou-Pekam, Ginette Irma Kame-Ngasse, Elisabeth Zeuko’o Menkem, Abdel Aziz Selly Ngaloumo, Agnès Thierry Rebecca Banlock, Alfloditte Flore Feudjio, Cromwel Zemnou-Tepap, Dowbiss Meta-Djomsi, Gilberte Louise Nyimbe Mviena, Ines Nyebe Eloundou, Jacqueline Félicité Yéngué, Josiane Kenfack-Zanguim, Juliette Laure Ndzie Ondigui, Ridole Martin Zekeng Mekontchou, Sabine Aimee Touangnou-Chamda, Yrene Kamtchueng Takeu, Jean Bosco Taya-Fokou, Chris Andre Mbongue Mikangue, Raoul Kenfack-Momo, Cyprien Kengne-Nde, Seraphine Nkie Esemu, Richard Njouom, and Lucy Ndip
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Medicine ,Science - Abstract
This study aimed to assess the global prevalence of occult hepatitis B in blood donors. We searched PubMed, Web of Science, Global Index Medicus, and Excerpta Medica Database. Study selection and data extraction were performed by at least two independent investigators. Heterogeneity (I2) was assessed using the χ2 test on the Cochran Q statistic and H parameters. Sources of heterogeneity were explored by subgroup analyses. This study is registered with PROSPERO, number CRD42021252787. We included 82 studies in this meta-analysis. The overall prevalence of OBI was 6.2% (95% CI: 5.4–7.1) in HBsAg negative and anti-HBc positive blood donors. Only sporadic cases of OBI were reported in HBsAg negative and anti-HBc negative blood donors. The overall prevalence of OBI was 0.2% (95% CI: 0.1–0.4) in HBsAg negative blood donors. The prevalence of OBI was generally higher in countries with low-income economic status. The results of this study show that despite routine screening of blood donors for hepatitis B, the transmission of HBV by blood remains possible via OBI and/or a seronegative window period; hence there is a need for active surveillance and foremost easier access to molecular tests for the screening of blood donors before transfusion.
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- 2022
22. A mapping review of methicillin-resistant Staphylococcus aureus proportions, genetic diversity, and antimicrobial resistance patterns in Cameroon
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Keneh, Nene Kaah, primary, Kenmoe, Sebastien, additional, Bowo-Ngandji, Arnol, additional, Tatah Kihla Akoachere, Jane-Francis, additional, Gonsu Kamga, Hortense, additional, Ndip, Roland Ndip, additional, Ebogo-Belobo, Jean Thierry, additional, Kengne-Ndé, Cyprien, additional, Mbaga, Donatien Serge, additional, Tendongfor, Nicholas, additional, Ndip, Lucy Mande, additional, and Esemu, Seraphine Nkie, additional
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- 2023
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23. Systematic review and meta-analysis of seroprevalence of human immunodeficiency virus serological markers among pregnant women in Africa, 1984-2020
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Ebogo-Belobo, Jean Thierry, primary, Kenmoe, Sebastien, additional, Mbongue Mikangue, Chris Andre, additional, Tchatchouang, Serges, additional, Robertine, Lontuo-Fogang, additional, Takuissu, Guy Roussel, additional, Ndzie Ondigui, Juliette Laure, additional, Bowo-Ngandji, Arnol, additional, Kenfack-Momo, Raoul, additional, Kengne-Ndé, Cyprien, additional, Mbaga, Donatien Serge, additional, Menkem, Elisabeth Zeuko'o, additional, Kame-Ngasse, Ginette Irma, additional, Magoudjou-Pekam, Jeannette Nina, additional, Kenfack-Zanguim, Josiane, additional, Esemu, Seraphine Nkie, additional, Tagnouokam-Ngoupo, Paul Alain, additional, Ndip, Lucy, additional, and Njouom, Richard, additional
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- 2023
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24. Assessing the Prevalence of Astroviruses in Water Environments: A Systematic Review and Meta-analysis
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Takuissu, Guy Roussel, primary, Kenmoe, Sebastien, additional, Ebogo-Belobo, Jean Thierry, additional, Kengne-Ndé, Cyprien, additional, Mbaga, Donatien Serge, additional, Bowo-Ngandji, Arnol, additional, Ndzie Ondigui, Juliette Laure, additional, Kenfack-Momo, Raoul, additional, Tchatchouang, Serges, additional, Kenfack-Zanguim, Josiane, additional, Lontuo Fogang, Robertine, additional, Zeuko’o Menkem, Elisabeth, additional, Kame-Ngasse, Ginette Irma, additional, Magoudjou-Pekam, Jeannette Nina, additional, Martella, Vito, additional, Veneri, Carolina, additional, Mancini, Pamela, additional, Ferraro, Giusy Bonanno, additional, Iaconelli, Marcello, additional, Suffredini, Elisabetta, additional, and La Rosa, Giuseppina, additional
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- 2023
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25. Epidemiology of rotavirus in humans, animals, and the environment in Africa: a systematic review and meta-analysis
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Njifon, Hermann Landry Munshili, primary, Kenmoe, Sebastien, additional, Ahmed, Sharia M, additional, Roussel Takuissu, Guy, additional, Ebogo-Belobo, Jean Thierry, additional, Njile, Daniel Kamga, additional, Bowo-Ngandji, Arnol, additional, Mbaga, Donatien Serge, additional, Kengne-Nde, Cyprien, additional, Mouiche, Mohamed Moctar Mouliom, additional, Njouom, Richard, additional, Perraut, Ronald, additional, and Leung, Daniel T, additional
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- 2023
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26. Incidence and seroprevalence of rabies virus in humans, dogs and other animal species in Africa, a systematic review and meta-analysis
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Jocelyne Noel Sowe Wobessi, Sebastien Kenmoe, Gadji Mahamat, Jean Thierry Ebogo Belobo, Cynthia Paola Demeni Emoh, Atembeh Noura Efietngab, Sandrine Rachel Kingue Bebey, Dimitri Tchami Ngongang, Serges Tchatchouang, Nathalie Diane Nzukui, Abdou Fatawou Modiyinji, Raïssa Estelle Guiamdjo Simo, Aude Christelle Ka'e, Hervé Raoul Tazokong, Arnol Bowo Ngandji, Donatien Serge Mbaga, Cyprien Kengne-Nde, Serge Alain Sadeuh-Mba, and Richard Njouom
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Rabies virus ,Incidence ,Africa ,One health ,Medicine (General) ,R5-920 - Abstract
Rabies is transmitted to humans mainly by dogs but also by other animal species. Reliable data on the incidence of Rabies virus (RABV) in humans, dogs, and other animal species in Africa, could be essential in the implementation of a global strategic plan to eliminate the RABV by 2030 as adopted by the WHO, OIE, and FAO. We searched the Pubmed, Embase, Scopus, African Journal Online, and African Index Medicus databases for relevant studies that report data on the incidence of RABV in Africa up to February 17, 2020. Information on active and past RABV exposures in various categories of dogs, humans and other animal species were extracted. Incidence and seroprevalence estimates were pooled using a random-effect meta-analysis. We included 73 articles which provided 142 RABV incidence and seroprevalence records in 21 African countries. The estimated incidence of RABV in 222 humans, 15,600 dogs, and 12,865 other animal species was 83.4% (95% CI = 64.6–96.5), 44.1% (95% CI = 35.1–53.4), and 41.4% (95% CI = 29.6–53.8), respectively. The estimated seroprevalence of RABV in 420 humans, 3577 dogs, and 8,55 other animal species was 33.8% (95% CI = 21.9–46.8), 19.8% (95% CI = 13.3–27.3), and 3.6% (95% CI = 0.3–9.2), respectively. The incidence of RABV in general was higher in suspected rabid dogs, other animal species of the Orders Perissodactyla, Artiodactyla and Carnivora. The incidence of RABV was higher for humans in regions of West and East Africa, for dogs in urban areas and in regions of Central and South Africa, and for animals of the order Perissodactyla in urban areas. This meta-analysis demonstrated a high incidence of RABV in Africa. Itis necessary to improve surveillance system to provide reliable data on RABV in Africa, essential for the implementation of an effective control strategy.
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- 2021
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27. Worldwide epidemiology of Crimean-Congo Hemorrhagic Fever Virus in humans, ticks and other animal species, a systematic review and meta-analysis.
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Jean Thierry Ebogo Belobo, Sebastien Kenmoe, Cyprien Kengne-Nde, Cynthia Paola Demeni Emoh, Arnol Bowo-Ngandji, Serges Tchatchouang, Jocelyne Noel Sowe Wobessi, Chris Andre Mbongue Mikangue, Hervé Raoul Tazokong, Sandrine Rachel Kingue Bebey, Efietngab Atembeh Noura, Aude Christelle Ka'e, Raïssa Estelle Guiamdjo Simo, Abdou Fatawou Modiyinji, Dimitri Tchami Ngongang, Emmanuel Che, Sorel Kenfack, Nathalie Diane Nzukui, Nathalie Amvongo Adjia, Isabelle Tatiana Babassagana, Gadji Mahamat, Donatien Serge Mbaga, Wilfred Fon Mbacham, Serge Alain Sadeuh-Mbah, and Richard Njouom
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
There are uncertainties about the global epidemiological data of infections due to Crimean-Congo hemorrhagic fever virus (CCHFV). We estimated the global case fatality rate (CFR) of CCHFV infections and the prevalence of CCHFV in humans, ticks and other animal species. We also explored the socio-demographic and clinical factors that influence these parameters. In this systematic review with meta-analyses we searched publications from database inception to 03rd February 2020 in Pubmed, Scopus, and Global Index Medicus. Studies included in this review provided cross-sectional data on the CFR and/or prevalence of one or more targets used for the detection of CCHFV. Two independent investigators selected studies to be included. Data extraction and risk of bias assessment were conducted independently by all authors. Data collected were analysed using a random effect meta-analysis. In all, 2345 records were found and a total of 312 articles (802 prevalence and/or CFR data) that met the inclusion criteria were retained. The overall CFR was 11.7% (95% CI = 9.1-14.5), 8.0% (95% CI = 1.0-18.9), and 4.7% (95% CI = 0.0-37.6) in humans with acute, recent, and past CCHFV infections respectively. The overall CCHFV acute infections prevalence was 22.5% (95% CI = 15.7-30.1) in humans, 2.1% (95% CI = 1.3-2.9) in ticks, and 4.5% (95% CI = 1.9-7.9) in other animal species. The overall CCHFV recent infections seroprevalence was 11.6% (95% CI = 7.9-16.4) in humans and 0.4% (95% CI = 0.0-2.9) in other animal species. The overall CCHFV past infections seroprevalence was 4.3% (95% CI = 3.3-5.4) in humans and 12.0% (95% CI = 9.9-14.3) in other animal species. CFR was higher in low-income countries, countries in the WHO African, South-East Asia and Eastern Mediterranean regions, in adult and ambulatory patients. CCHFV detection rate in humans were higher in CCHFV suspected cases, healthcare workers, adult and hospitalized patients, ticks of the genus Ornithodoros and Amblyomma and in animals of the orders Perissodactyla and Bucerotiformes. This review highlights a significant disease burden due to CCHFV with a strong disparity according to country income levels, geographic regions, various human categories and tick and other animal species. Preventive measures in the light of these findings are expected.
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- 2021
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28. Contemporary epidemiological data of Rift Valley fever virus in humans, mosquitoes and other animal species in Africa: A systematic review and meta‐analysis
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Ebogo‐Belobo, Jean Thierry, primary, Kenmoe, Sebastien, additional, Abanda, Ngu Njei, additional, Bowo‐Ngandji, Arnol, additional, Mbaga, Donatien Serge, additional, Magoudjou‐Pekam, Jeannette Nina, additional, Kame‐Ngasse, Ginette Irma, additional, Tchatchouang, Serges, additional, Menkem, Elisabeth Zeuko'o, additional, Okobalemba, Etienne Atenguena, additional, Noura, Efietngab Atembeh, additional, Meta‐Djomsi, Dowbiss, additional, Maïdadi‐Foudi, Martin, additional, Kenfack‐Zanguim, Josiane, additional, Kenfack‐Momo, Raoul, additional, Kengne‐Nde, Cyprien, additional, Esemu, Seraphine Nkie, additional, Mbacham, Wilfred Fon, additional, Sadeuh‐Mba, Serge Alain, additional, Ndip, Lucy, additional, and Njouom, Richard, additional
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- 2023
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29. Association between early viral LRTI and subsequent wheezing development, a meta-analysis and sensitivity analyses for studies comparable for confounding factors.
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Sebastien Kenmoe, Arnol Bowo-Ngandji, Cyprien Kengne-Nde, Jean Thierry Ebogo-Belobo, Donatien Serge Mbaga, Gadji Mahamat, Cynthia Paola Demeni Emoh, and Richard Njouom
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Medicine ,Science - Abstract
IntroductionConsideration of confounding factors about the association between Lower Respiratory Tract Infections (LRTI) in childhood and the development of subsequent wheezing has been incompletely described. We determined the association between viral LRTI at ≤ 5 years of age and the development of wheezing in adolescence or adulthood by a meta-analysis and a sensitivity analysis including comparable studies for major confounding factors.MethodsWe performed searches through Pubmed and Global Index Medicus databases. We selected cohort studies comparing the frequency of subsequent wheezing in children with and without LRTI in childhood regardless of the associated virus. We extracted the publication data, clinical and socio-demographic characteristics of the children, and confounding factors. We analyzed data using random effect model.ResultsThe meta-analysis included 18 publications (22 studies) that met the inclusion criteria. These studies showed that viral LRTI in children ≤ 3 years was associated with an increased risk of subsequent development of wheezing (OR = 3.1, 95% CI = 2.4-3.9). The risk of developing subsequent wheezing was conserved when considering studies with comparable groups for socio-demographic and clinical confounders.ConclusionsWhen considering studies with comparable groups for most confounding factors, our results provided strong evidence for the association between neonatal viral LRTI and the subsequent wheezing development. Further studies, particularly from lower-middle income countries, are needed to investigate the role of non-bronchiolitis and non-HRSV LRTI in the association between viral LRTI in childhood and the wheezing development later. In addition, more studies are needed to investigate the causal effect between childhood viral LRTI and the wheezing development later.Trial registrationReview registration: PROSPERO, CRD42018116955; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018116955.
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- 2021
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30. Diabetes mellitus and tuberculosis, a systematic review and meta-analysis with sensitivity analysis for studies comparable for confounders
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Joseph Rodrigue Foe-Essomba, Sebastien Kenmoe, Serges Tchatchouang, Jean Thierry Ebogo-Belobo, Donatien Serge Mbaga, Cyprien Kengne-Ndé, Gadji Mahamat, Ginette Irma Kame-Ngasse, Efietngab Atembeh Noura, Chris Andre Mbongue Mikangue, Alfloditte Flore Feudjio, Jean Bosco Taya-Fokou, Sabine Aimee Touangnou-Chamda, Rachel Audrey Nayang-Mundo, Inès Nyebe, Jeannette Nina Magoudjou-Pekam, Jacqueline Félicité Yéngué, Larissa Gertrude Djukouo, Cynthia Paola Demeni Emoh, Hervé Raoul Tazokong, Arnol Bowo-Ngandji, Eric Lontchi-Yimagou, Afi Leslie Kaiyven, Valerie Flore Donkeng Donfack, Richard Njouom, Jean Claude Mbanya, Wilfred Fon Mbacham, and Sara Eyangoh
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Medicine ,Science - Published
- 2021
31. Systematic review and meta-analysis of the epidemiology of Lassa virus in humans, rodents and other mammals in sub-Saharan Africa.
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Sebastien Kenmoe, Serges Tchatchouang, Jean Thierry Ebogo-Belobo, Aude Christelle Ka'e, Gadji Mahamat, Raïssa Estelle Guiamdjo Simo, Arnol Bowo-Ngandji, Cynthia Paola Demeni Emoh, Emmanuel Che, Dimitri Tchami Ngongang, Marie Amougou-Atsama, Nathalie Diane Nzukui, Chris Andre Mbongue Mikangue, Donatien Serge Mbaga, Sorel Kenfack, Sandrine Rachel Kingue Bebey, Nathalie Amvongo Adjia, Atembeh Noura Efietngab, Hervé Raoul Tazokong, Abdou Fatawou Modiyinji, Cyprien Kengne-Nde, Serge Alain Sadeuh-Mba, and Richard Njouom
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
Accurate data on the Lassa virus (LASV) human case fatality rate (CFR) and the prevalence of LASV in humans, rodents and other mammals are needed for better planning of actions that will ultimately reduce the burden of LASV infection in sub-Saharan Africa. In this systematic review with meta-analysis, we searched PubMed, Scopus, Africa Journal Online, and African Index Medicus from 1969 to 2020 to obtain studies that reported enough data to calculate LASV infection CFR or prevalence. Study selection, data extraction, and risk of bias assessment were conducted independently. We extracted all measures of current, recent, and past infections with LASV. Prevalence and CFR estimates were pooled using a random-effect meta-analysis. Factors associated with CFR, prevalence, and sources of between-study heterogeneity were determined using subgroup and metaregression analyses. This review was registered with PROSPERO, CRD42020166465. We initially identified 1,399 records and finally retained 109 reports that contributed to 291 prevalence records from 25 countries. The overall CFR was 29.7% (22.3-37.5) in humans. Pooled prevalence of LASV infection was 8.7% (95% confidence interval: 6.8-10.8) in humans, 3.2% (1.9-4.6) in rodents, and 0.7% (0.0-2.3) in other mammals. Subgroup and metaregression analyses revealed a substantial statistical heterogeneity explained by higher prevalence in tissue organs, in case-control, in hospital outbreak, and surveys, in retrospective studies, in urban and hospital setting, in hospitalized patients, and in West African countries. This study suggests that LASV infections is an important cause of death in humans and that LASV are common in humans, rodents and other mammals in sub-Saharan Africa. These estimates highlight disparities between sub-regions, and population risk profiles. Western Africa, and specific key populations were identified as having higher LASV CFR and prevalence, hence, deserving more attention for cost-effective preventive interventions.
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- 2020
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32. Hepatitis E Virus in Water Environments: A Systematic Review and Meta-analysis
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G. R. Takuissu, S. Kenmoe, L. Ndip, J. T. Ebogo-Belobo, C. Kengne-Ndé, D. S. Mbaga, A. Bowo-Ngandji, M. G. Oyono, R. Kenfack-Momo, S. Tchatchouang, J. Kenfack-Zanguim, R. Lontuo Fogang, E. Zeuko’o Menkem, G. I. Kame-Ngasse, J. N. Magoudjou-Pekam, S. Nkie Esemu, C. Veneri, P. Mancini, G. Bonanno Ferraro, M. Iaconelli, E. Suffredini, and G. La Rosa
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Swine ,Epidemiology ,Developed Countries ,Drinking Water ,Virology ,Health, Toxicology and Mutagenesis ,Hepatitis E virus ,Animals ,Humans ,Wastewater ,Hepatitis E ,Food Science - Abstract
Hepatitis E virus (HEV) is responsible for acute hepatitis in humans, through foodborne, zoonotic, and waterborne transmission routes. This study aimed to assess the prevalence of HEV in water matrices. Six categories were defined: untreated and treated wastewater, surface water (river, lake, and seawater), drinking water, groundwater, and other water environments (irrigation water, grey water, reservoir water, flood water, and effluent of pig slaughterhouse). We searched PubMed, Web of Science, Global Index Medicus, and Excerpta Medica Database. Study selection and data extraction were performed by at least two independent investigators. Heterogeneity (I2) was assessed using the χ2 test on the Cochran Q statistic and H parameter. Sources of heterogeneity were explored by subgroup analysis. This study is registered with PROSPERO, number CRD42021289116. We included 87 prevalence studies from 58 papers, 66.4% of which performed in Europe. The overall prevalence of HEV in water was 9.8% (95% CI 6.4–13.7). The prevalence was higher in untreated wastewater (15.1%) and lower in treated wastewater (3.8%) and in drinking water (4.7%). In surface water, prevalence was 7.4%, and in groundwater, the percentage of positive samples, from only one study available, was 8.3%. Overall, only 36.8% of the studies reported the genotype of HEV, with genotype 3 (HEV-3) prevalent (168 samples), followed by HEV-1 (148 sample), and HEV-4 (2 samples). High-income countries were the most represented with 59/87 studies (67.8%), while only 3/87 (3.5%) of the studies were performed in low-income countries. The overall prevalence obtained of this study was generally higher in industrialized countries. Risk of bias was low in 14.9% of the studies and moderate in 85.1%. The results of this review showed the occurrence of HEV in different waters environments also in industrialized countries with sanitation and safe water supplies. While HEV transmission to humans through water has been widely demonstrated in developing countries, it is an issue still pending in industrialized countries. Better knowledge on the source of pollution, occurrence, survival in water, and removal by water treatment is needed to unravel this transmission path. Graphical Abstract
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- 2022
33. Occurrence of Hepatitis A Virus in Water Matrices: A Systematic Review and Meta-Analysis
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Takuissu, Guy Roussel, primary, Kenmoe, Sebastien, additional, Ebogo-Belobo, Jean Thierry, additional, Kengne-Ndé, Cyprien, additional, Mbaga, Donatien Serge, additional, Bowo-Ngandji, Arnol, additional, Ndzie Ondigui, Juliette Laure, additional, Kenfack-Momo, Raoul, additional, Tchatchouang, Serges, additional, Kenfack-Zanguim, Josiane, additional, Lontuo Fogang, Robertine, additional, Zeuko’o Menkem, Elisabeth, additional, Kame-Ngasse, Ginette Irma, additional, Magoudjou-Pekam, Jeannette Nina, additional, Veneri, Carolina, additional, Mancini, Pamela, additional, Bonanno Ferraro, Giusy, additional, Iaconelli, Marcello, additional, Orlandi, Lidia, additional, Del Giudice, Claudia, additional, Suffredini, Elisabetta, additional, and La Rosa, Giuseppina, additional
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- 2023
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34. Prevalence of the metabolic syndrome in African populations: A systematic review and meta-analysis.
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Bowo-Ngandji, Arnol, Kenmoe, Sebastien, Ebogo-Belobo, Jean Thierry, Kenfack-Momo, Raoul, Takuissu, Guy Roussel, Kengne-Ndé, Cyprien, Mbaga, Donatien Serge, Tchatchouang, Serges, Kenfack-Zanguim, Josiane, Lontuo Fogang, Robertine, Zeuko'o Menkem, Elisabeth, Ndzie Ondigui, Juliette Laure, Kame-Ngasse, Ginette Irma, Magoudjou-Pekam, Jeannette Nina, Wandji Nguedjo, Maxwell, Assam Assam, Jean Paul, Enyegue Mandob, Damaris, and Ngondi, Judith Laure
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RANDOM effects model , *AFRICANS , *METABOLIC syndrome , *EPIDEMIOLOGICAL transition , *TYPE 2 diabetes , *CORONARY artery disease , *DEMOGRAPHIC transition - Abstract
Background: The metabolic syndrome (MS) is a leading cause of death worldwide. Several studies have found MS to be prevalent in various African regions. However, no specific estimates of MS prevalence in African populations exist. The aim of this study was to estimate the overall prevalence of MS in the African populations. Methods: A systematic review was conducted in PubMed, Web of Science, Africa Index Medicus, and African Journal Online Scopus to find studies published up to the 15th of August 2022. Pooled prevalence was calculated based on six diagnostic methods. The pooled prevalence of MS was estimated using a random-effects model. Our risk of bias analysis was based on the Hoy et al. tool. A Heterogeneity (I2) assessment was performed, as well as an Egger test for publication bias. PROSPERO number CRD42021275176 was assigned to this study. Results: In total, 297 studies corresponding to 345 prevalence data from 29 African countries and involving 156 464 participants were included. The overall prevalence of MS in Africa was 32.4% (95% CI: 30.2–34.7) with significant heterogeneity (I2 = 98.9%; P<0.001). We obtained prevalence rates of 44.8% (95% CI: 24.8–65.7), 39.7% (95% CI: 31.7–48.1), 33.1% (95% CI: 28.5–37.8), 31.6% (95% CI: 27.8–35.6) and 29.3% (95% CI: 25.7–33) using the WHO, revised NCEP-ATP III, JIS, NCEP/ATP III and IDF definition criteria, respectively. The prevalence of MS was significantly higher in adults >18 years with 33.1% (95%CI: 30.8–35.5) compared to children <18 years with 13.3% (95%CI: 7.3–20.6) (P<0.001). MS prevalence was significantly higher in females with 36.9% (95%CI: 33.2–40.7) compared to males with 26.7% (95%CI: 23.1–30.5) (P<0.001). The prevalence of MS was highest among Type 2 diabetes patients with 66.9% (95%CI: 60.3–73.1), followed by patients with coronary artery disease with 55.2% (95%CI: 50.8–59.6) and cardiovascular diseases with 48.3% (95%CI: 33.5–63.3) (P<0.001). With 33.6% (95% CI: 28.3–39.1), the southern African region was the most affected, followed by upper-middle income economies with 35% (95% CI: 29.5–40.6). Conclusion: This study, regardless of the definition used, reveals a high prevalence of MS in Africa, confirming the ongoing epidemiological transition in African countries. Early prevention and treatment strategies are urgently needed to reverse this trend. [ABSTRACT FROM AUTHOR]
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- 2023
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35. A State-of-the-Art Scoping Review on SARS-CoV-2 in Sewage Focusing on the Potential of Wastewater Surveillance for the Monitoring of the COVID-19 Pandemic
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G. Bonanno Ferraro, Cyprien Kengne-Nde, Sebastien Kenmoe, Lucia Bonadonna, Elisabetta Suffredini, Gadji Mahamat, Luca Lucentini, Marcello Iaconelli, J T Ebogo-Belobo, Carolina Veneri, G. La Rosa, Hervé Raoul Tazokong, Pamela Mancini, Richard Njouom, Arnol Bowo-Ngandji, and Donatien Serge Mbaga
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medicine.medical_specialty ,Wastewater-Based Epidemiological Monitoring ,Epidemiology ,Health, Toxicology and Mutagenesis ,Population ,Sewage ,Wastewater ,Communicable Diseases ,Virology ,Environmental health ,Pandemic ,medicine ,Humans ,education ,Pandemics ,education.field_of_study ,Review Paper ,Surveillance ,business.industry ,SARS-CoV-2 ,Public health ,Outbreak ,COVID-19 ,Geography ,Early warning system ,Sewage treatment ,business ,Food Science - Abstract
The outbreak of coronavirus infectious disease-2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has rapidly spread throughout the world. Several studies have shown that detecting SARS-CoV-2 in untreated wastewater can be a useful tool to identify new outbreaks, establish outbreak trends, and assess the prevalence of infections. On 06 May 2021, over a year into the pandemic, we conducted a scoping review aiming to summarize research data on SARS-CoV-2 in sewage. Papers dealing with raw sewage collected at wastewater treatment plants, sewer networks, septic tanks, and sludge treatment facilities were included in this review. We also reviewed studies on sewage collected in community settings such as private or municipal hospitals, healthcare facilities, nursing homes, dormitories, campuses, airports, aircraft, and cruise ships. The literature search was conducted using the electronic databases PubMed, EMBASE, and Web Science Core Collection. This comprehensive research yielded 1090 results, 66 of which met the inclusion criteria and are discussed in this review. Studies from 26 countries worldwide have investigated the occurrence of SARS-CoV-2 in sewage of different origin. The percentage of positive samples in sewage ranged from 11.6 to 100%, with viral concentrations ranging from ˂LOD to 4.6 × 108 genome copies/L. This review outlines the evidence currently available on wastewater surveillance: (i) as an early warning system capable of predicting COVID-19 outbreaks days or weeks before clinical cases; (ii) as a tool capable of establishing trends in current outbreaks; (iii) estimating the prevalence of infections; and (iv) studying SARS-CoV-2 genetic diversity. In conclusion, as a cost-effective, rapid, and reliable source of information on the spread of SARS-CoV-2 and its variants in the population, wastewater surveillance can enhance genomic and epidemiological surveillance with independent and complementary data to inform public health decision-making during the ongoing pandemic. Graphic Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s12560-021-09498-6.
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- 2021
36. Global prevalence of hepatitis B virus serological markers among healthcare workers: A systematic review and meta-analysis
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Dowbiss Meta-Djomsi, Jean Joel Bigna, Efietngab Atembeh Noura, Joseph Rodrigue Foe-Essomba, Audrey Gaelle Daha-Tchoffo, Dimitri Tchami Ngongang, Jacqueline Félicité Yengue, Richard Njouom, Sabine Aimee Touangnou-Chamda, Jean Bosco Taya-Fokou, Etheline W Akazong, Lorraine K M Fokou, Rachel Audrey Nayang-Mundo, Marie Amougou-Atsama, Chavely Gwladys Monamele, Hervé Raoul Tazokong, Donatien Serge Mbaga, Cynthia Paola Demeni Emoh, Jean Thierry Ebogo-Belobo, Raoul Kenfack-Momo, Martin Maïdadi-Foudi, Abdel Aziz Selly-Ngaloumo, Jeannette Nina Magoudjou-Pekam, Arnol Bowo-Ngandji, Onana Boyomo, Cromwel Zemnou-Tepap, Cyprien Kengne-Nde, Sebastien Kenmoe, Chris Andre Mbongue Mikangue, Ginette Irma Kame-Ngasse, and Gadji Mahamat
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Hepatitis B virus ,Hepatitis e antigen ,Hepatology ,business.industry ,education ,virus diseases ,Seroprevalence ,Hepatitis b surface antigen ,medicine.disease_cause ,Virology ,digestive system diseases ,Serology ,Hepatitis E antigen ,Hepatitis B surface antigen ,Meta-analysis ,Health care ,medicine ,Healthcare workers ,business ,Meta-Analysis - Abstract
BACKGROUND The hepatitis B virus (HBV) infection is a global public health concern that affects about 2 billion people and causes 1 million people deaths yearly. HBV is a blood-borne disease and healthcare workers (HCWs) are a high-risk group because of occupational hazard to patients’ blood. Different regions of the world show a highly variable proportion of HCWs infected and/or immunized against HBV. Global data on serologic markers of HBV infection and immunization in HCWs are very important to improve strategies for HBV control. AIM To determine the worldwide prevalence of HBV serological markers among HCWs. METHODS In this systematic review and meta–analyses, we searched PubMed and Excerpta Medica Database (Embase) to identify studies published between 1970 and 2019 on the prevalence of HBV serological markers in HCWs worldwide. We also manually searched for references of relevant articles. Four independent investigators selected studies and included those on the prevalence of each of the HBV serological markers including hepatitis B surface antigen (HBsAg), hepatitis e antigen (HBeAg), immunoglobulin M anti-HBc, and anti-HBs. Methodological quality of eligible studies was assessed and random-effect model meta-analysis resulted in the pooled prevalence of HBV serological markers HBV infection in HCWs. Heterogeneity (I²) was assessed using the χ² test on Cochran’s Q statistic and H parameters. Heterogeneity’ sources were explored through subgroup and metaregression analyses. This study is registered with PROSPERO, number CRD42019137144. RESULTS We reviewed 14059 references, out of which 227 studies corresponding to 448 prevalence data among HCWs (224936 HCWs recruited from 1964 to 2019 in 71 countries) were included in this meta-analysis. The pooled seroprevalences of current HBsAg, current HBeAg, and acute HBV infection among HCWs were 2.3% [95% confidence interval (CI): 1.9-2.7], 0.2% (95%CI: 0.0-1.7), and 5.3% (95%CI: 1.4-11.2), respectively. The pooled seroprevalences of total immunity against HBV and immunity acquired by natural HBV infection in HCWs were 56.6% (95%CI: 48.7-63.4) and 9.2% (95%CI: 6.8-11.8), respectively. HBV infection was more prevalent in HCWs in low-income countries, particularly in Africa. The highest immunization rates against HBV in HCWs were recorded in urban areas and in high-income countries including Europe, the Eastern Mediterranean and the Western Pacific. CONCLUSION New strategies are needed to improve awareness, training, screening, vaccination, post-exposure management and treatment of HBV infection in HCWs, and particularly in low-income regions.
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- 2021
37. Global epidemiology of occult hepatitis B virus infections in blood donors, a systematic review and meta-analysis
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Takuissu, Guy Roussel, primary, Kenmoe, Sebastien, additional, Amougou Atsama, Marie, additional, Atenguena Okobalemba, Etienne, additional, Mbaga, Donatien Serge, additional, Ebogo-Belobo, Jean Thierry, additional, Bowo-Ngandji, Arnol, additional, Oyono, Martin Gael, additional, Magoudjou-Pekam, Jeannette Nina, additional, Kame-Ngasse, Ginette Irma, additional, Menkem, Elisabeth Zeuko’o, additional, Selly Ngaloumo, Abdel Aziz, additional, Banlock, Agnès Thierry Rebecca, additional, Feudjio, Alfloditte Flore, additional, Zemnou-Tepap, Cromwel, additional, Meta-Djomsi, Dowbiss, additional, Nyimbe Mviena, Gilberte Louise, additional, Nyebe Eloundou, Ines, additional, Yéngué, Jacqueline Félicité, additional, Kenfack-Zanguim, Josiane, additional, Ndzie Ondigui, Juliette Laure, additional, Zekeng Mekontchou, Ridole Martin, additional, Touangnou-Chamda, Sabine Aimee, additional, Kamtchueng Takeu, Yrene, additional, Taya-Fokou, Jean Bosco, additional, Mbongue Mikangue, Chris Andre, additional, Kenfack-Momo, Raoul, additional, Kengne-Nde, Cyprien, additional, Nkie Esemu, Seraphine, additional, Njouom, Richard, additional, and Ndip, Lucy, additional
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- 2022
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38. Epidemiology of yellow fever virus in humans, arthropods, and non-human primates in sub-Saharan Africa: A systematic review and meta-analysis
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Oyono, Martin Gael, primary, Kenmoe, Sebastien, additional, Abanda, Ngu Njei, additional, Takuissu, Guy Roussel, additional, Ebogo-Belobo, Jean Thierry, additional, Kenfack-Momo, Raoul, additional, Kengne-Nde, Cyprien, additional, Mbaga, Donatien Serge, additional, Tchatchouang, Serges, additional, Kenfack-Zanguim, Josiane, additional, Lontuo Fogang, Robertine, additional, Zeuko’o Menkem, Elisabeth, additional, Ndzie Ondigui, Juliette Laure, additional, Kame-Ngasse, Ginette Irma, additional, Magoudjou-Pekam, Jeannette Nina, additional, Bowo-Ngandji, Arnol, additional, Nkie Esemu, Seraphine, additional, and Ndip, Lucy, additional
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- 2022
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39. Association between early viral lower respiratory tract infections and subsequent asthma development
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Kenmoe, Sebastien, primary, Atenguena Okobalemba, Etienne, additional, Takuissu, Guy Roussel, additional, Ebogo-Belobo, Jean Thierry, additional, Oyono, Martin Gael, additional, Magoudjou-Pekam, Jeannette Nina, additional, Kame-Ngasse, Ginette Irma, additional, Taya-Fokou, Jean Bosco, additional, Mbongue Mikangue, Chris Andre, additional, Kenfack-Momo, Raoul, additional, Mbaga, Donatien Serge, additional, Bowo-Ngandji, Arnol, additional, Kengne-Ndé, Cyprien, additional, Esemu, Seraphine Nkie, additional, Njouom, Richard, additional, and Ndip, Lucy, additional
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- 2022
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40. Transmission Dynamics of Intestinal Parasites Infection in Children under Anthelminthic Treatment Residing in a High-Risk Area in Cameroon
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Atembeh-Noura Efietngab, Nkengazong Lucia, Djabidatou Ousmanou, Arnol Bowo-Ngandji, Ngonde Marie Chantal, and Halmata Mohamadou
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Transmission (mechanics) ,Risk area ,law ,business.industry ,Environmental health ,parasitic diseases ,Medicine ,General Medicine ,business ,law.invention - Abstract
Introduction: Intestinal parasites continue to pose an important public health problem in low-income countries with children being the most affected, thus justifying their therapeutic follow up. Objective: This work aimed to update the epidemiological base data and evaluate transmission dynamics of intestinal parasites at one and three months post treatment following the administration of multiple doses of mebendazole 100mg in children of the Lolodorf health district, South Region. Methods: 381 stool samples were collected from participants and analysed using the kato-katz and formol ether technicsand each participant treated with multiple dosesof mebendazole within three days. Samples were collected at one and three months post treatment from same individuals. Two indicators were used to evaluate transmission dynamics: reinfection rate and number of newly infected individuals. Results: A global infection rate of 65.3% involving Ascaris lumbricoides (23.1 %), Trichuris trichiura (35.2 %), hookworms (7.9 %), Hymenolepis diminuta (0.3 %), Entamoeba histolytica/E. dispar (5.8 %), Entamoeba coli (19.2 %), Entamoeba hartmanni (0.3 %) and Candida sp (26.0 %) was registered. Single infection (53.6%) was significantly higher than multiple infections (46.4%) (P=0.04). Significance was in favour of male sex for hookworm infections (P=0.04). Transmission dynamics of the different groups of parasites showed a reduction of helminths and protozoan parasites infections with complete absence of Candida sp. after treatment. The global reinfection rate obtained at three months post treatment was 7.3% with high values observed for T. trichiura (6.1%). The proportion of newly infected individuals varied from 6.2% to 8.9% at one and three months post treatment. Conclusion: These results showed persistence in active transmission of various intestinal parasites in the study area. Hence, stakeholders in charge of controlling theseinfections shouldreinforce specific intervention measures against these diseases such as the implication of control measures at all levels of the transmission chain (individual and environmental level).
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- 2021
41. Epidemiology of hepatitis B virus and/or hepatitis C virus infections among people living with human immunodeficiency virus in Africa: A systematic review and meta-analysis
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Kenfack-Momo, Raoul, primary, Kenmoe, Sebastien, additional, Takuissu, Guy Roussel, additional, Ebogo-Belobo, Jean Thierry, additional, Kengne-Ndé, Cyprien, additional, Mbaga, Donatien Serge, additional, Tchatchouang, Serges, additional, Oyono, Martin Gael, additional, Kenfack-Zanguim, Josiane, additional, Lontuo Fogang, Robertine, additional, Mbongue Mikangue, Chris Andre, additional, Zeuko’o Menkem, Elisabeth, additional, Ndzie Ondigui, Juliette Laure, additional, Kame-Ngasse, Ginette Irma, additional, Magoudjou-Pekam, Jeannette Nina, additional, Taya-Fokou, Jean Bosco, additional, Bowo-Ngandji, Arnol, additional, Nkie Esemu, Seraphine, additional, Kamdem Thiomo, Diane, additional, Moundipa Fewou, Paul, additional, Ndip, Lucy, additional, and Njouom, Richard, additional
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- 2022
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42. Global prevalence of occult hepatitis C virus: A systematic review and meta-analysis
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Mbaga, Donatien Serge, primary, Kenmoe, Sebastien, additional, Bikoï, Jacky Njiki, additional, Takuissu, Guy Roussel, additional, Amougou-Atsama, Marie, additional, Okobalemba, Etienne Atenguena, additional, Ebogo-Belobo, Jean Thierry, additional, Bowo-Ngandji, Arnol, additional, Oyono, Martin Gael, additional, Magoudjou-Pekam, Jeannette Nina, additional, Kame-Ngasse, Ginette Irma, additional, Nka, Alex Durand, additional, Feudjio, Alfloditte Flore, additional, Zemnou-Tepap, Cromwel, additional, Velhima, Elie Adamou, additional, Ondigui, Juliette Laure Ndzie, additional, Nayang-Mundo, Rachel Audrey, additional, Touangnou-Chamda, Sabine Aimee, additional, Takeu, Yrene Kamtchueng, additional, Taya-Fokou, Jean Bosco, additional, Mikangue, Chris Andre Mbongue, additional, Kenfack-Momo, Raoul, additional, Kengne-Ndé, Cyprien, additional, Sake, Carole Stephanie, additional, Esemu, Seraphine Nkie, additional, Njouom, Richard, additional, Ndip, Lucy, additional, and Essama, Sara Honorine Riwom, additional
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- 2022
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43. Occurrence of Hepatitis A Virus in Water Matrices: A Systematic Review and Meta-Analysis
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Guy Roussel Takuissu, Sebastien Kenmoe, Jean Thierry Ebogo-Belobo, Cyprien Kengne-Ndé, Donatien Serge Mbaga, Arnol Bowo-Ngandji, Juliette Laure Ndzie Ondigui, Raoul Kenfack-Momo, Serges Tchatchouang, Josiane Kenfack-Zanguim, Robertine Lontuo Fogang, Elisabeth Zeuko’o Menkem, Ginette Irma Kame-Ngasse, Jeannette Nina Magoudjou-Pekam, Carolina Veneri, Pamela Mancini, Giusy Bonanno Ferraro, Marcello Iaconelli, Lidia Orlandi, Claudia Del Giudice, Elisabetta Suffredini, and Giuseppina La Rosa
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Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health - Abstract
Hepatitis A is a common form of viral hepatitis. It is usually transmitted through the ingestion of contaminated food and water. This systematic review was carried out to summarise the overall prevalence of Hepatitis A virus (HAV) in different water matrices: untreated and treated wastewater, surface water, groundwater, drinking water, and others (e.g., irrigation water and floodwater). The literature search was performed in four databases: PubMed, Web of Science, Global Index Medicus, and Excerpta Medica Database. Heterogeneity (I2) was assessed using the χ2 test on the Cochran Q statistic and H parameters. A total of 200 prevalence data from 144 articles were included in this meta-analysis. The overall prevalence of HAV in water matrices was 16.7% (95% CI: 13.4–20.3). The prevalence for individual matrix was as follows: 31.4% (95% CI: 23.0–40.4) untreated wastewater, 18.0% (95% CI: 9.5–28.2) treated wastewater, 15.0% (95% CI: 10.1–20.5) surface water, 2.3% (95% CI: 0.1–6.0) in groundwater, 0.3% (95% CI: 0.0–1.7) in drinking water, and 8.5% (95% CI: 3.1–15.6) in other matrices. The prevalence was higher in low-income economies (29.0%). Africa and Eastern Mediterranean were the regions with higher HAV prevalence values. This study showed a high heterogeneity (I2 > 75%) with a significant publication bias (p value Egger test < 0.001). The results of this review suggest that water matrices could be an important route of HAV transmission even in industrialized countries, despite the lower prevalence compared to less industrialized countries, and the availability of advanced water management systems. More effective water/wastewater treatment strategies are needed in developing countries to limit the environmental circulation of HAV.
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- 2023
44. Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis
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Fall, Amary, primary, Kenmoe, Sebastien, additional, Ebogo-Belobo, Jean Thierry, additional, Mbaga, Donatien Serge, additional, Bowo-Ngandji, Arnol, additional, Foe-Essomba, Joseph Rodrigue, additional, Tchatchouang, Serges, additional, Amougou Atsama, Marie, additional, Yéngué, Jacqueline Félicité, additional, Kenfack-Momo, Raoul, additional, Feudjio, Alfloditte Flore, additional, Nka, Alex Durand, additional, Mbongue Mikangue, Chris Andre, additional, Taya-Fokou, Jean Bosco, additional, Magoudjou-Pekam, Jeannette Nina, additional, Noura, Efietngab Atembeh, additional, Zemnou-Tepap, Cromwel, additional, Meta-Djomsi, Dowbiss, additional, Maïdadi-Foudi, Martin, additional, Kame-Ngasse, Ginette Irma, additional, Nyebe, Inès, additional, Djukouo, Larissa Gertrude, additional, Kengne Gounmadje, Landry, additional, Tchami Ngongang, Dimitri, additional, Oyono, Martin Gael, additional, Demeni Emoh, Cynthia Paola, additional, Tazokong, Hervé Raoul, additional, Mahamat, Gadji, additional, Kengne-Ndé, Cyprien, additional, Sadeuh-Mba, Serge Alain, additional, Dia, Ndongo, additional, La Rosa, Giuseppina, additional, Ndip, Lucy, additional, and Njouom, Richard, additional
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- 2022
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45. Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders
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Mbaga, Donatien Serge, primary, Kenmoe, Sebastien, additional, Kengne-Ndé, Cyprien, additional, Ebogo-Belobo, Jean Thierry, additional, Mahamat, Gadji, additional, Foe-Essomba, Joseph Rodrigue, additional, Amougou-Atsama, Marie, additional, Tchatchouang, Serges, additional, Nyebe, Inès, additional, Feudjio, Alfloditte Flore, additional, Kame-Ngasse, Ginette Irma, additional, Magoudjou-Pekam, Jeannette Nina, additional, Fokou, Lorraine K. M., additional, Meta-Djomsi, Dowbiss, additional, Maïdadi-Foudi, Martin, additional, Touangnou-Chamda, Sabine Aimee, additional, Daha-Tchoffo, Audrey Gaelle, additional, Selly-Ngaloumo, Abdel Aziz, additional, Nayang-Mundo, Rachel Audrey, additional, Yéngué, Jacqueline Félicité, additional, Taya-Fokou, Jean Bosco, additional, Kenfack-Momo, Raoul, additional, Atembeh Noura, Efietngab, additional, Demeni Emoh, Cynthia Paola, additional, Tazokong, Hervé Raoul, additional, Bowo-Ngandji, Arnol, additional, Sake, Carole Stéphanie, additional, Atenguena Okobalemba, Etienne, additional, Njiki Bikoi, Jacky, additional, Njouom, Richard, additional, and Riwom Essama, Sara Honorine, additional
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- 2022
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46. Global prevalence of occult hepatitis C virus: A systematic review and meta-analysis
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Donatien Serge Mbaga, Sebastien Kenmoe, Jacky Njiki Bikoï, Guy Roussel Takuissu, Marie Amougou-Atsama, Etienne Atenguena Okobalemba, Jean Thierry Ebogo-Belobo, Arnol Bowo-Ngandji, Martin Gael Oyono, Jeannette Nina Magoudjou-Pekam, Ginette Irma Kame-Ngasse, Alex Durand Nka, Alfloditte Flore Feudjio, Cromwel Zemnou-Tepap, Elie Adamou Velhima, Juliette Laure Ndzie Ondigui, Rachel Audrey Nayang-Mundo, Sabine Aimee Touangnou-Chamda, Yrene Kamtchueng Takeu, Jean Bosco Taya-Fokou, Chris Andre Mbongue Mikangue, Raoul Kenfack-Momo, Cyprien Kengne-Ndé, Carole Stephanie Sake, Seraphine Nkie Esemu, Richard Njouom, Lucy Ndip, and Sara Honorine Riwom Essama
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Occult hepatitis C infection (OCI) is characterized by the presence of hepatitis C virus (HCV) RNA in the liver, peripheral blood mononuclear cells (PBMC) and/or ultracentrifuged serum in the absence of detectable HCV-RNA in serum. OCI has been described in several categories of populations including hemodialysis patients, patients with a sustained virological response, immunocompromised individuals, patients with abnormal hepatic function, and apparently healthy subjects.To highlight the global prevalence of OCI.We performed a systematic and comprehensive literature search in the following 4 electronic databases PubMed, EMBASE, Global Index Medicus, and Web of Science up to 6th May 2021 to retrieve relevant studies published in the field. Included studies were unrestricted population categories with known RNA status in serum, PBMC, liver tissue and/or ultracentrifuged serum. Data were extracted independently by each author and the HoyThe electronic search resulted in 3950 articles. We obtained 102 prevalence data from 85 included studies. The pooled prevalence of seronegative OCI was estimated to be 9.61% (95%CI: 6.84-12.73) with substantial heterogeneity [In conclusion, in the present study, it appears that the burden of OCI is high and variable across the different regions and population categories. Further studies on OCI are needed to assess the transmissibility, clinical significance, long-term outcome, and need for treatment.
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- 2021
47. Incidence and seroprevalence of rabies virus in humans, dogs and other animal species in Africa, a systematic review and meta-analysis
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Dimitri Tchami Ngongang, Sandrine Rachel Kingue Bebey, Arnol Bowo Ngandji, Jean Thierry Ebogo Belobo, Cynthia Paola Demeni Emoh, Atembeh Noura Efietngab, Nathalie Diane Nzukui, Gadji Mahamat, Aude Christelle Ka'e, Serge Alain Sadeuh-Mba, Jocelyne Noel Sowe Wobessi, Donatien Serge Mbaga, Serges Tchatchouang, Raïssa Estelle Guiamdjo Simo, Hervé Raoul Tazokong, Cyprien Kengne-Nde, Sebastien Kenmoe, Abdou Fatawou Modiyinji, and Richard Njouom
- Subjects
Medicine (General) ,030231 tropical medicine ,Biology ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,R5-920 ,medicine ,East africa ,Seroprevalence ,030212 general & internal medicine ,Animal species ,One health ,Review Paper ,Incidence (epidemiology) ,Incidence ,Rabies virus ,Public Health, Environmental and Occupational Health ,medicine.disease ,Infectious Diseases ,One Health ,Meta-analysis ,Africa ,Rabies ,Demography - Abstract
Rabies is transmitted to humans mainly by dogs but also by other animal species. Reliable data on the incidence of Rabies virus (RABV) in humans, dogs, and other animal species in Africa, could be essential in the implementation of a global strategic plan to eliminate the RABV by 2030 as adopted by the WHO, OIE, and FAO. We searched the Pubmed, Embase, Scopus, African Journal Online, and African Index Medicus databases for relevant studies that report data on the incidence of RABV in Africa up to February 17, 2020. Information on active and past RABV exposures in various categories of dogs, humans and other animal species were extracted. Incidence and seroprevalence estimates were pooled using a random-effect meta-analysis. We included 73 articles which provided 142 RABV incidence and seroprevalence records in 21 African countries. The estimated incidence of RABV in 222 humans, 15,600 dogs, and 12,865 other animal species was 83.4% (95% CI = 64.6–96.5), 44.1% (95% CI = 35.1–53.4), and 41.4% (95% CI = 29.6–53.8), respectively. The estimated seroprevalence of RABV in 420 humans, 3577 dogs, and 8,55 other animal species was 33.8% (95% CI = 21.9–46.8), 19.8% (95% CI = 13.3–27.3), and 3.6% (95% CI = 0.3–9.2), respectively. The incidence of RABV in general was higher in suspected rabid dogs, other animal species of the Orders Perissodactyla, Artiodactyla and Carnivora. The incidence of RABV was higher for humans in regions of West and East Africa, for dogs in urban areas and in regions of Central and South Africa, and for animals of the order Perissodactyla in urban areas. This meta-analysis demonstrated a high incidence of RABV in Africa. Itis necessary to improve surveillance system to provide reliable data on RABV in Africa, essential for the implementation of an effective control strategy.
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- 2021
48. Association between early viral lower respiratory tract infections and subsequent asthma development
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Sebastien Kenmoe, Etienne Atenguena Okobalemba, Guy Roussel Takuissu, Jean Thierry Ebogo-Belobo, Martin Gael Oyono, Jeannette Nina Magoudjou-Pekam, Ginette Irma Kame-Ngasse, Jean Bosco Taya-Fokou, Chris Andre Mbongue Mikangue, Raoul Kenfack-Momo, Donatien Serge Mbaga, Arnol Bowo-Ngandji, Cyprien Kengne-Ndé, Seraphine Nkie Esemu, Richard Njouom, and Lucy Ndip
- Abstract
The association between hospitalization for human respiratory syncytial virus (HRSV) bronchiolitis in early childhood and subsequent asthma is well established. The long-term prognosis for non-bronchiolitis lower respiratory tract infections (LRTI) caused by viruses different from HRSV and rhinovirus, on the other hand, has received less interest.To investigate the relationship between infant LRTI and later asthma and examine the influence of confounding factors.The PubMed and Global Index Medicus bibliographic databases were used to search for articles published up to October 2021 for this systematic review. We included cohort studies comparing the incidence of asthma between patients with and without LRTI at ≤ 2 years regardless of the virus responsible. The meta-analysis was performed using the random effects model. Sources of heterogeneity were assessed by stratified analyses.This review included 15 articles (18 unique studies) that met the inclusion criteria. LRTIs at ≤ 2 years were associated with an increased risk of subsequent asthma up to 20 years [odds ratio (OR) = 5.0, 95%CI: 3.3-7.5], with doctor-diagnosed asthma (OR = 5.3, 95%CI: 3.3-8.6), current asthma (OR = 5.4, 95%CI: 2.7-10.6), and current medication for asthma (OR = 1.2, 95%CI: 0.7-3.9). Our overall estimates were not affected by publication bias (Regardless of the causative virus and confounding factors, viral LRTIs in children2 years are associated with an increased risk of developing a subsequent asthma. Parents and pediatricians should be informed of this risk.
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- 2021
49. Diabetes mellitus and tuberculosis, a systematic review and meta-analysis with sensitivity analysis for studies comparable for confounders
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Foe-Essomba, Joseph Rodrigue, primary, Kenmoe, Sebastien, additional, Tchatchouang, Serges, additional, Ebogo-Belobo, Jean Thierry, additional, Mbaga, Donatien Serge, additional, Kengne-Ndé, Cyprien, additional, Mahamat, Gadji, additional, Kame-Ngasse, Ginette Irma, additional, Noura, Efietngab Atembeh, additional, Mbongue Mikangue, Chris Andre, additional, Feudjio, Alfloditte Flore, additional, Taya-Fokou, Jean Bosco, additional, Touangnou-Chamda, Sabine Aimee, additional, Nayang-Mundo, Rachel Audrey, additional, Nyebe, Inès, additional, Magoudjou-Pekam, Jeannette Nina, additional, Yéngué, Jacqueline Félicité, additional, Djukouo, Larissa Gertrude, additional, Demeni Emoh, Cynthia Paola, additional, Tazokong, Hervé Raoul, additional, Bowo-Ngandji, Arnol, additional, Lontchi-Yimagou, Eric, additional, Kaiyven, Afi Leslie, additional, Donkeng Donfack, Valerie Flore, additional, Njouom, Richard, additional, Mbanya, Jean Claude, additional, Mbacham, Wilfred Fon, additional, and Eyangoh, Sara, additional
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- 2021
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50. A State-of-the-Art Scoping Review on SARS-CoV-2 in Sewage Focusing on the Potential of Wastewater Surveillance for the Monitoring of the COVID-19 Pandemic
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Bonanno Ferraro, G., primary, Veneri, C., additional, Mancini, P., additional, Iaconelli, M., additional, Suffredini, E., additional, Bonadonna, L., additional, Lucentini, L., additional, Bowo-Ngandji, A., additional, Kengne-Nde, C., additional, Mbaga, D. S., additional, Mahamat, G., additional, Tazokong, H. R., additional, Ebogo-Belobo, J. T., additional, Njouom, R., additional, Kenmoe, S., additional, and La Rosa, G., additional
- Published
- 2021
- Full Text
- View/download PDF
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