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1. Determinants of survival after first relapse of acute lymphoblastic leukemia: a Children’s Oncology Group study

Author

Rheingold, Susan R., Bhojwani, Deepa, Ji, Lingyun, Xu, Xinxin, Devidas, Meenakshi, Kairalla, John A., Shago, Mary, Heerema, Nyla A., Carroll, Andrew J., Breidenbach, Heather, Borowitz, Michael, Wood, Brent L., Angiolillo, Anne L., Asselin, Barbara L., Bowman, W. Paul, Brown, Patrick, Dreyer, ZoAnn E., Dunsmore, Kimberly P., Hilden, Joanne M., Larsen, Eric, Maloney, Kelly, Matloub, Yousif, Mattano, Leonard A., Winter, Stuart S., Gore, Lia, Winick, Naomi J., Carroll, William L., Hunger, Stephen P., Raetz, Elizabeth A., and Loh, Mignon L.

Published
2024
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3. Outcomes in patients with ETV6::RUNX1or high-hyperdiploid B-ALL treated in the St. Jude Total Therapy XV/XVI studies

Author

Purvis, Katelyn, Zhou, Yinmei, Karol, Seth E., Rubnitz, Jeffrey E., Ribeiro, Raul C., Lee, Shawn, Yang, Jun J., Bowman, W. Paul, Wang, Lu, Dixon, Stephanie B., Roberts, Kathryn G., Gao, Qingsong, Cheng, Cheng, Mullighan, Charles G., Jeha, Sima, Pui, Ching-Hon, and Inaba, Hiroto

Abstract

•Among NCI high-risk patients, 93% with ETV6::RUNX1and 54% with hyperdiploid B-ALL had excellent outcomes with low-intensity therapy.•NCI high-risk patients with hyperdiploid B-ALL and slow early MRD response had worse outcomes and, therefore, require new approaches.

Published
2025
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6. Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study

Author

Moriyama, Takaya, Metzger, Monika L, Wu, Gang, Nishii, Rina, Qian, Maoxiang, Devidas, Meenakshi, Yang, Wenjian, Cheng, Cheng, Cao, Xueyuan, Quinn, Emily, Raimondi, Susana, Gastier-Foster, Julie M, Raetz, Elizabeth, Larsen, Eric, Martin, Paul L, Bowman, W Paul, Winick, Naomi, Komada, Yoshihiro, Wang, Shuoguo, Edmonson, Michael, Xu, Heng, Mardis, Elaine, Fulton, Robert, Pui, Ching-Hon, Mullighan, Charles, Evans, William E, Zhang, Jinghui, Hunger, Stephen P, Relling, Mary V, Nichols, Kim E, Loh, Mignon L, and Yang, Jun J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetic Testing, Hematology, Human Genome, Clinical Research, Cancer, Childhood Leukemia, Genetics, Pediatric Cancer, Rare Diseases, Pediatric, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Age Factors, Biomarkers, Tumor, Case-Control Studies, Child, Child, Preschool, Computational Biology, DNA Mutational Analysis, Databases, Genetic, Exome, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Germ-Line Mutation, Humans, Karyotyping, Male, Phenotype, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Proto-Oncogene Proteins c-ets, Repressor Proteins, Risk Factors, Treatment Outcome, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundHereditary predisposition is rarely suspected for childhood acute lymphoblastic leukaemia (ALL). Recent reports of germline ETV6 variations associated with substantial familial clustering of haematological malignancies indicated that this gene is a potentially important genetic determinant for ALL susceptibility. Our aims in this study were to comprehensively identify ALL predisposition variants in ETV6 and to determine the extent to which they contributed to the overall risk of childhood ALL.MethodsWhole-exome sequencing of an index family with several cases of ALL was done to identify causal variants for ALL predisposition. Targeted sequencing of ETV6 was done in children from the Children's Oncology Group and St Jude Children's Research Hospital front-line ALL trials. Patients were included in this study on the basis of their enrolment in these clinical trials and the availability of germline DNA. ETV6 variant genotypes were compared with non-ALL controls to define ALL-related germline risk variants. ETV6 variant function was characterised bioinformatically and correlated with clinical and demographic features in children with ALL.FindingsWe identified a novel non-sense ETV6 variant (p.Arg359X) with a high penetrance in an index family. Subsequent targeted sequencing of ETV6 in 4405 childhood ALL cases identified 31 exonic variants (four non-sense, 21 missense, one splice site, and five frameshift variants) that were potentially related to ALL risk in 35 cases (1%). 15 (48%) of 31 ALL-related ETV6 variants clustered in the erythroblast transformation specific domain and were predicted to be highly deleterious. Children with ALL-related ETV6 variants were significantly older at leukaemia diagnosis than those without (10·2 years [IQR 5·3-13·8] vs 4·7 years [3·0-8·7]; p=0·017). The hyperdiploid leukaemia karyotype was highly over-represented in ALL cases harbouring germline ETV6 risk variants compared with the wild-type group (nine [64%] of 14 cases vs 538 [27%] of 2007 cases; p=0·0050).InterpretationOur findings indicated germline ETV6 variations as the basis of a novel genetic syndrome associated with predisposition to childhood ALL. The development of recommendations for clinical interventions and surveillance for individuals harbouring ALL-related ETV6 variants are needed.FundingUS National Institutes of Health and American Lebanese Syrian Associated Charities.

Published
2015

7. Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children.

Author

Xu, Heng, Zhang, Hui, Yang, Wenjian, Yadav, Rachita, Morrison, Alanna C, Qian, Maoxiang, Devidas, Meenakshi, Liu, Yu, Perez-Andreu, Virginia, Zhao, Xujie, Gastier-Foster, Julie M, Lupo, Philip J, Neale, Geoff, Raetz, Elizabeth, Larsen, Eric, Bowman, W Paul, Carroll, William L, Winick, Naomi, Williams, Richard, Hansen, Torben, Holm, Jens-Christian, Mardis, Elaine, Fulton, Robert, Pui, Ching-Hon, Zhang, Jinghui, Mullighan, Charles G, Evans, William E, Hunger, Stephen P, Gupta, Ramneek, Schmiegelow, Kjeld, Loh, Mignon L, Relling, Mary V, and Yang, Jun J

Subjects
Hematopoietic Stem Cells, Animals, Humans, Mice, Genetic Predisposition to Disease, DNA-Binding Proteins, Transcription Factors, Case-Control Studies, Mutagenesis, Site-Directed, Genotype, Germ-Line Mutation, Mutation, Missense, Child, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p15, Ikaros Transcription Factor, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Genetic Variation, Genome-Wide Association Study, HEK293 Cells, Mutagenesis, Site-Directed, Mutation, Missense
Abstract

There is increasing evidence from genome-wide association studies for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children, yet the effects of protein-coding variants on ALL risk have not been systematically evaluated. Here we show a missense variant in CDKN2A associated with the development of ALL at genome-wide significance (rs3731249, P=9.4 × 10(-23), odds ratio=2.23). Functional studies indicate that this hypomorphic variant results in reduced tumour suppressor function of p16(INK4A), increases the susceptibility to leukaemic transformation of haematopoietic progenitor cells, and is preferentially retained in ALL tumour cells. Resequencing the CDKN2A-CDKN2B locus in 2,407 childhood ALL cases reveals 19 additional putative functional germline variants. These results provide direct functional evidence for the influence of inherited genetic variation on ALL risk, highlighting the important and complex roles of CDKN2A-CDKN2B tumour suppressors in leukaemogenesis.

Published
2015

8. Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse.

Author

Perez-Andreu, Virginia, Roberts, Kathryn G, Harvey, Richard C, Yang, Wenjian, Cheng, Cheng, Pei, Deqing, Xu, Heng, Gastier-Foster, Julie, E, Shuyu, Lim, Joshua Yew-Suang, Chen, I-Ming, Fan, Yiping, Devidas, Meenakshi, Borowitz, Michael J, Smith, Colton, Neale, Geoffrey, Burchard, Esteban G, Torgerson, Dara G, Klussmann, Federico Antillon, Villagran, Cesar Rolando Najera, Winick, Naomi J, Camitta, Bruce M, Raetz, Elizabeth, Wood, Brent, Yue, Feng, Carroll, William L, Larsen, Eric, Bowman, W Paul, Loh, Mignon L, Dean, Michael, Bhojwani, Deepa, Pui, Ching-Hon, Evans, William E, Relling, Mary V, Hunger, Stephen P, Willman, Cheryl L, Mullighan, Charles G, and Yang, Jun J

Subjects
Humans, Genetic Predisposition to Disease, Recurrence, Risk, Case-Control Studies, Gene Frequency, Genotype, Inheritance Patterns, Polymorphism, Single Nucleotide, Child, GATA3 Transcription Factor, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Genome-Wide Association Study, Cancer, Childhood Leukemia, Rare Diseases, Pediatric, Hematology, Orphan Drug, Pediatric Research Initiative, Pediatric Cancer, Genetics, Aetiology, 2.1 Biological and endogenous factors, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Recent genomic profiling of childhood acute lymphoblastic leukemia (ALL) identified a high-risk subtype with an expression signature resembling that of Philadelphia chromosome-positive ALL and poor prognosis (Ph-like ALL). However, the role of inherited genetic variation in Ph-like ALL pathogenesis remains unknown. In a genome-wide association study (GWAS) of 511 ALL cases and 6,661 non-ALL controls, we identified a susceptibility locus for Ph-like ALL (GATA3, rs3824662; P = 2.17 × 10(-14), odds ratio (OR) = 3.85 for Ph-like ALL versus non-ALL; P = 1.05 × 10(-8), OR = 3.25 for Ph-like ALL versus non-Ph-like ALL), with independent validation. The rs3824662 risk allele was associated with somatic lesions underlying Ph-like ALL (CRLF2 rearrangement, JAK gene mutation and IKZF1 deletion) and with variation in GATA3 expression. Finally, genotype at the GATA3 SNP was also associated with early treatment response and risk of ALL relapse. Our results provide insights into interactions between inherited and somatic variants and their role in ALL pathogenesis and prognosis.

Published
2013

9. Novel Susceptibility Variants at 10p12.31-12.2 for Childhood Acute Lymphoblastic Leukemia in Ethnically Diverse Populations

Author

Xu, Heng, Yang, Wenjian, Perez-Andreu, Virginia, Devidas, Meenakshi, Fan, Yiping, Cheng, Cheng, Pei, Deqing, Scheet, Paul, Burchard, Esteban González, Eng, Celeste, Huntsman, Scott, Torgerson, Dara G, Dean, Michael, Winick, Naomi J, Martin, Paul L, Camitta, Bruce M, Bowman, W Paul, Willman, Cheryl L, Carroll, William L, Mullighan, Charles G, Bhojwani, Deepa, Hunger, Stephen P, Pui, Ching-Hon, Evans, William E, Relling, Mary V, Loh, Mignon L, and Yang, Jun J

Subjects
Hematology, Rare Diseases, Cancer, Human Genome, Pediatric Cancer, Pediatric, Prevention, Childhood Leukemia, Clinical Research, Genetics, Aetiology, 2.1 Biological and endogenous factors, Adolescent, African Americans, CCAAT-Enhancer-Binding Proteins, Child, Child, Preschool, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 7, DNA-Binding Proteins, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Hispanic or Latino, Humans, Ikaros Transcription Factor, Logistic Models, Male, Mitogen-Activated Protein Kinase 7, Neoplasm Proteins, Phosphotransferases (Alcohol Group Acceptor), Polymorphism, Single Nucleotide, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Risk Assessment, Risk Factors, Transcription Factors, Whites, White People, Black or African American, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundAcute lymphoblastic leukemia (ALL) is the most common cancer in children and the incidence of ALL varies by ethnicity. Although accumulating evidence indicates inherited predisposition to ALL, the genetic basis of ALL susceptibility in diverse ancestry has not been comprehensively examined.MethodsWe performed a multiethnic genome-wide association study in 1605 children with ALL and 6661 control subjects after adjusting for population structure, with validation in three replication series of 845 case subjects and 4316 control subjects. Association was tested by two-sided logistic regression.ResultsA novel ALL susceptibility locus at 10p12.31-12.2 (BMI1-PIP4K2A, rs7088318, P = 1.1 × 10(-11)) was identified in the genome-wide association study, with independent replication in European Americans, African Americans, and Hispanic Americans (P = .001, .009, and .04, respectively). Association was also validated at four known ALL susceptibility loci: ARID5B, IKZF1, CEBPE, and CDKN2A/2B. Associations at ARID5B, IKZF1, and BMI1-PIP4K2A variants were consistent across ethnicity, with multiple independent signals at IKZF1 and BMI1-PIP4K2A loci. The frequency of ARID5B and BMI1-PIP4K2A variants differed by ethnicity, in parallel with ethnic differences in ALL incidence. Suggestive evidence for modifying effects of age on genetic predisposition to ALL was also observed. ARID5B, IKZF1, CEBPE, and BMI1-PIP4K2A variants cumulatively conferred strong predisposition to ALL, with children carrying six to eight copies of risk alleles at a ninefold (95% confidence interval = 6.9 to 11.8) higher ALL risk relative to those carrying zero to one risk allele at these four single nucleotide polymorphisms.ConclusionsThese findings indicate strong associations between inherited genetic variation and ALL susceptibility in children and shed new light on ALL molecular etiology in diverse ancestry.

Published
2013

12. Genome-wide analysis links NFATC2 with asparaginase hypersensitivity

Author

Fernandez, Christian A., Smith, Colton, Yang, Wenjian, Mullighan, Charles G., Qu, Chunxu, Larsen, Eric, Bowman, W. Paul, Liu, Chengcheng, Ramsey, Laura B., Chang, Tamara, Karol, Seth E., Loh, Mignon L., Raetz, Elizabeth A., Winick, Naomi J., Hunger, Stephen P., Carroll, William L., Jeha, Sima, Pui, Ching-Hon, Evans, William E., Devidas, Meenakshi, and Relling, Mary V.

Published
2015
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13. Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study

Author

Pui, Ching-Hon, Pei, Deqing, Coustan-Smith, Elaine, Jeha, Sima, Cheng, Cheng, Bowman, W Paul, Sandlund, John T, Ribeiro, Raul C, Rubnitz, Jeffrey E, Inaba, Hiroto, Bhojwani, Deepa, Gruber, Tanja A, Leung, Wing H, Downing, James R, Evans, William E, Relling, Mary V, and Campana, Dario

Published
2015
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16. Identification of TCF3 germline variants in pediatric B-cell acute lymphoblastic leukemia

Author

Escherich, Carolin S., primary, Chen, Wenan, additional, Miyamoto, Satoshi, additional, Namikawa, Yui, additional, Yang, Wenjian, additional, Teachey, David T., additional, Li, Zhenhua, additional, Raetz, Elizabeth A., additional, Larsen, Eric C., additional, Devidas, Meenakshi, additional, Martin, Paul L, additional, Bowman, W. Paul, additional, Wu, Gang, additional, Pui, Ching-Hon, additional, Hunger, Stephen P., additional, Loh, Mignon L., additional, Takagi, Masatoshi, additional, and Yang, Jun J., additional

Published
2022
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18. HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies

Author

Fernandez, Christian A., Smith, Colton, Yang, Wenjian, Daté, Mihir, Bashford, Donald, Larsen, Eric, Bowman, W. Paul, Liu, Chengcheng, Ramsey, Laura B., Chang, Tamara, Turner, Victoria, Loh, Mignon L., Raetz, Elizabeth A., Winick, Naomi J., Hunger, Stephen P., Carroll, William L., Onengut-Gumuscu, Suna, Chen, Wei-Min, Concannon, Patrick, Rich, Stephen S., Scheet, Paul, Jeha, Sima, Pui, Ching-Hon, Evans, William E., Devidas, Meenakshi, and Relling, Mary V.

Published
2014
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21. Rare Deleterious TCF3 Germline Variants and Predisposition to Acute Lymphoblastic Leukemia in Children

Author

Escherich, Carolin, primary, Chen, Wenan, additional, Miyamoto, Satoshi, additional, Namikawa, Yui, additional, Yang, Wenjian, additional, Teachey, David T., additional, Li, Zhenhua, additional, Raetz, Elizabeth A., additional, Larsen, Eric C, additional, Devidas, Meenakshi, additional, Martin, Paul L., additional, Bowman, W Paul, additional, Wu, Gang, additional, Pui, Ching-Hon, additional, Hunger, Stephen P., additional, Takagi, Masatoshi, additional, Yang, Jun J., additional, and Loh, Mignon L., additional

Published
2022
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22. An Investigation of Principals and Assistant Principals in Pennsylvania and the Impact of Transitional Support Programs on Job Satisfaction

Author

Bowman, W. David

Abstract

The primary purpose of this study was to assess the impact of the GROW program on the intrinsic, extrinsic, and the general job satisfaction of principals and assistant principals in Pennsylvania. The impact of the variables of year in position, age, gender, level of work, location of school, and present degree was examined; the impact of mentoring programs, professional development activities, satisfaction with professional development, an assistant principal's desire to become a principal, and the satisfaction of a principal or assistant principal as compared to his/her satisfaction as a teacher was investigated. Job satisfaction was measured using the Short-form of the Minnesota Satisfaction Questionnaire (MSQ). The target population was comprised of principals and assistant principal who were in the 2nd to 5th year in their position. One thousand, thirty-two participants responded; this yielded a 53.09% response rate. One thousand, nine participants completed the survey; the completion rate was 97.77%. Ninety-two percent of the public school districts in Pennsylvania were represented in this study. One-way analysis of variance, Chi-square tests, and Tukey's post-hoc multiple comparisons were employed. No statistically significant differences were found between intrinsic, extrinsic or general job satisfaction and participating or not participating in the GROW program. Significant differences were found between the extrinsic job satisfaction of the principals and assistant principals who were in the 2nd year in their position and those who were in their 5th year; significant differences were found between the job satisfaction of those who worked in an urban setting and those who worked in a rural or suburban location. Significant differences were also found between those who did and those who did not participate in mentoring programs and professional development activities, between assistant principals who did and those who did not desire to be a principal, and between principals and assistant principals who were and those who were not satisfied as compared to their satisfaction as a teacher. The principals and assistant principals who participated in this study were more satisfied with intrinsic job satisfaction, were slightly less satisfied with general job satisfaction and, had a lower level of extrinsic job satisfaction. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]

Published
2009

23. Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia

Author

Yang, Jun J., Cheng, Cheng, Devidas, Meenakshi, Cao, Xueyuan, Campana, Dario, Yang, Wenjian, Fan, Yiping, Neale, Geoff, Cox, Nancy, Scheet, Paul, Borowitz, Michael J., Winick, Naomi J., Martin, Paul L., Bowman, W. Paul, Camitta, Bruce, Reaman, Gregory H., Carroll, William L., Willman, Cheryl L., Hunger, Stephen P., Evans, William E., Pui, Ching-Hon, Loh, Mignon, and Relling, Mary V.

Published
2012
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24. Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group Study

Author

Chen, I-Ming, Harvey, Richard C., Mullighan, Charles G., Gastier-Foster, Julie, Wharton, Walker, Kang, Huining, Borowitz, Michael J., Camitta, Bruce M., Carroll, Andrew J., Devidas, Meenakshi, Pullen, D. Jeanette, Payne-Turner, Debbie, Tasian, Sarah K., Reshmi, Shalini, Cottrell, Catherine E., Reaman, Gregory H., Bowman, W. Paul, Carroll, William L., Loh, Mignon L., Winick, Naomi J., Hunger, Stephen P., and Willman, Cheryl L.

Published
2012
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26. Do trade-offs govern plant species’ responses to different global change treatments?

Author

Langley, J. A. (J. Adam), Grman, E. (Emily), Wilcox, K. R. (Kevin R.), Avolio, M. L. (Meghan L), Komatsu, K. J. (Kimberly J.), Collins, S. L. (Scott L.), Koerner, S. E. (Sally E.), Smith, M. D. (Melinda D.), Baldwin, A. H. (Andrew H.), Bowman, W. (William), Chiariello, N. (Nona), Eskelinen, A. (Anu), Harmens, H. (Harry), Hovenden, M. (Mark), Klanderud, K. (Kari), McCulley, R. L. (Rebecca L.), Onipchenko, V. G. (Vladimir G.), Robinson, C. H. (Clare H.), Suding, K. N. (Katharine N.), Langley, J. A. (J. Adam), Grman, E. (Emily), Wilcox, K. R. (Kevin R.), Avolio, M. L. (Meghan L), Komatsu, K. J. (Kimberly J.), Collins, S. L. (Scott L.), Koerner, S. E. (Sally E.), Smith, M. D. (Melinda D.), Baldwin, A. H. (Andrew H.), Bowman, W. (William), Chiariello, N. (Nona), Eskelinen, A. (Anu), Harmens, H. (Harry), Hovenden, M. (Mark), Klanderud, K. (Kari), McCulley, R. L. (Rebecca L.), Onipchenko, V. G. (Vladimir G.), Robinson, C. H. (Clare H.), and Suding, K. N. (Katharine N.)

Abstract

Plants are subject to trade-offs among growth strategies such that adaptations for optimal growth in one condition can preclude optimal growth in another. Thus, we predicted that a plant species that responds positively to one global change treatment would be less likely than average to respond positively to another treatment, particularly for pairs of treatments that favor distinct traits. We examined plant species’ abundances in 39 global change experiments manipulating two or more of the following: CO₂, nitrogen, phosphorus, water, temperature, or disturbance. Overall, the directional response of a species to one treatment was 13% more likely than expected to oppose its response to a another single-factor treatment. This tendency was detectable across the global data set, but held little predictive power for individual treatment combinations or within individual experiments. Although trade-offs in the ability to respond to different global change treatments exert discernible global effects, other forces obscure their influence in local communities.

Published
2022

29. Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

Author

Zhang, Jinghui, Mullighan, Charles G., Harvey, Richard C., Wu, Gang, Chen, Xiang, Edmonson, Michael, Buetow, Kenneth H., Carroll, William L., Chen, I-Ming, Devidas, Meenakshi, Gerhard, Daniela S., Loh, Mignon L., Reaman, Gregory H., Relling, Mary V., Camitta, Bruce M., Bowman, W. Paul, Smith, Malcolm A., Willman, Cheryl L., Downing, James R., and Hunger, Stephen P.

Published
2011
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37. Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome

Author

Harvey, Richard C., Mullighan, Charles G., Wang, Xuefei, Dobbin, Kevin K., Davidson, George S., Bedrick, Edward J., Chen, I-Ming, Atlas, Susan R., Kang, Huining, Ar, Kerem, Wilson, Carla S., Wharton, Walker, Murphy, Maurice, Devidas, Meenakshi, Carroll, Andrew J., Borowitz, Michael J., Bowman, W. Paul, Downing, James R., Relling, Mary, Yang, Jun, Bhojwani, Deepa, Carroll, William L., Camitta, Bruce, Reaman, Gregory H., Smith, Malcolm, Hunger, Stephen P., and Willman, Cheryl L.

Published
2010
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38. Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

Author

Harvey, Richard C., Mullighan, Charles G., Chen, I-Ming, Wharton, Walker, Mikhail, Fady M., Carroll, Andrew J., Kang, Huining, Liu, Wei, Dobbin, Kevin K., Smith, Malcolm A., Carroll, William L., Devidas, Meenakshi, Bowman, W. Paul, Camitta, Bruce M., Reaman, Gregory H., Hunger, Stephen P., Downing, James R., and Willman, Cheryl L.

Published
2010
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39. Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia

Author

Kang, Huining, Chen, I.-Ming, Wilson, Carla S., Bedrick, Edward J., Harvey, Richard C., Atlas, Susan R., Devidas, Meenakshi, Mullighan, Charles G., Wang, Xuefei, Murphy, Maurice, Ar, Kerem, Wharton, Walker, Borowitz, Michael J., Bowman, W. Paul, Bhojwani, Deepa, Carroll, William L., Camitta, Bruce M., Reaman, Gregory H., Smith, Malcolm A., Downing, James R., Hunger, Stephen P., and Willman, Cheryl L.

Published
2010
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40. Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial

Author

Rubnitz, Jeffrey E, Inaba, Hiroto, Dahl, Gary, Ribeiro, Raul C, Bowman, W Paul, Taub, Jeffrey, Pounds, Stanley, Razzouk, Bassem I, Lacayo, Norman J, Cao, Xueyuan, Meshinchi, Soheil, Degar, Barbara, Airewele, Gladstone, Raimondi, Susana C, Onciu, Mihaela, Coustan-Smith, Elaine, Downing, James R, Leung, Wing, Pui, Ching-Hon, and Campana, Dario

Published
2010
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