Search

Your search keyword '"Bowie, William"' showing total 606 results
Start Over Author "Bowie, William"
606 results on '"Bowie, William"'

1. Xenomake: a pipeline for processing and sorting xenograft reads from spatial transcriptomic experiments.

Author

Strope, Benjamin S, Pendleton, Katherine E, Bowie, William Z, Echeverria, Gloria V, and Zhu, Qian

Subjects
HUMAN biology, TRANSCRIPTOMES, TUMOR microenvironment, DOCUMENTATION, GENES
Abstract

Summary Xenograft models are attractive models that mimic human tumor biology and permit one to perturb the tumor microenvironment and study its drug response. Spatially resolved transcriptomics (SRT) provides a powerful way to study the organization of xenograft models, but currently there is a lack of specialized pipeline for processing xenograft reads originated from SRT experiments. Xenomake is a standalone pipeline for the automated handling of spatial xenograft reads. Xenomake handles read processing, alignment, xenograft read sorting, and connects well with downstream spatial analysis packages. We additionally show that Xenomake can correctly assign organism-specific reads, reduce sparsity of data by increasing gene counts, while maintaining biological relevance for studies. Availability and implementation Xenomake is an open-source program that is available on Github (https://github.com/qianzhulab/Xenomake). Complete documentation can be found at the link. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

2. Predicting major clinical events among Canadian adults with laboratory-confirmed influenza infection using the influenza severity scale.

Author

Pott, Henrique, LeBlanc, Jason J., ElSherif, May, Hatchette, Todd F., McNeil, Shelly A., Andrew, Melissa K., Boivin, Guy, Trottier, Sylvie, Diaz-Mitoma, Francisco, Verschoor, Chris, Stiver, Grant, Bowie, William, Green, Karen, McGeer, Allison, Johnstone, Jennie, Loeb, Mark, Katz, Kevin, Lagacé-Wiens, Phillipe, Light, Bruce, and McCarthy, Anne

Abstract

We developed and validated the Influenza Severity Scale (ISS), a standardized risk assessment for influenza, to estimate and predict the probability of major clinical events in patients with laboratory-confirmed infection. Data from the Canadian Immunization Research Network’s Serious Outcomes Surveillance Network (2011/2012–2018/2019 influenza seasons) enabled the selecting of all laboratory-confirmed influenza patients. A machine learning-based approach then identified variables, generated weighted scores, and evaluated model performance. This study included 12,954 patients with laboratory-confirmed influenza infections. The optimal scale encompassed ten variables: demographic (age and sex), health history (smoking status, chronic pulmonary disease, diabetes mellitus, and influenza vaccination status), clinical presentation (cough, sputum production, and shortness of breath), and function (need for regular support for activities of daily living). As a continuous variable, the scale had an AU-ROC of 0.73 (95% CI, 0.71–0.74). Aggregated scores classified participants into three risk categories: low (ISS < 30; 79.9% sensitivity, 51% specificity), moderate (ISS ≥ 30 but < 50; 54.5% sensitivity, 55.9% specificity), and high (ISS ≥ 50; 51.4% sensitivity, 80.5% specificity). ISS demonstrated a solid ability to identify patients with hospitalized laboratory-confirmed influenza at increased risk for Major Clinical Events, potentially impacting clinical practice and research. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. Effectiveness of Influenza Vaccination on Hospitalizations and Risk Factors for Severe Outcomes in Hospitalized Patients With COPD

Author

Lagace-Wiens, Philippe, Light, Bruce, Poirier, Andre, Smith, Stephanie, Taylor, Gregory, Mulpuru, Sunita, Li, Li, Ye, Lingyun, Hatchette, Todd, Andrew, Melissa K., Ambrose, Ardith, Boivin, Guy, Bowie, William, Chit, Ayman, Dos Santos, Gael, ElSherif, May, Green, Karen, Haguinet, Francois, Halperin, Scott A., Ibarguchi, Barbara, Johnstone, Jennie, Katz, Kevin, Langley, Joanne M., LeBlanc, Jason, Loeb, Mark, MacKinnon-Cameron, Donna, McCarthy, Anne, McElhaney, Janet E., McGeer, Allison, Powis, Jeff, Richardson, David, Semret, Makeda, Shinde, Vivek, Smyth, Daniel, Trottier, Sylvie, Valiquette, Louis, Webster, Duncan, and McNeil, Shelly A.

Published
2019
Full Text
View/download PDF

6. Vaccine Effectiveness of non-adjuvanted and adjuvanted trivalent inactivated influenza vaccines in the prevention of influenza-related hospitalization in older adults: A pooled analysis from the Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN)

Author

Pott, Henrique, primary, Andrew, Melissa K., additional, Shaffelburg, Zachary, additional, Nichols, Michaela K., additional, Ye, Lingyun, additional, ElSherif, May, additional, Hatchette, Todd F., additional, LeBlanc, Jason, additional, Ambrose, Ardith, additional, Boivin, Guy, additional, Bowie, William, additional, Johnstone, Jennie, additional, Katz, Kevin, additional, Lagacé-Wiens, Phillipe, additional, Loeb, Mark, additional, McCarthy, Anne, additional, McGeer, Allison, additional, Poirier, Andre, additional, Powis, Jeff, additional, Richardson, David, additional, Semret, Makeda, additional, Smith, Stephanie, additional, Smyth, Daniel, additional, Stiver, Grant, additional, Trottier, Sylvie, additional, Valiquette, Louis, additional, Webster, Duncan, additional, and McNeil, Shelly A., additional

Published
2023
Full Text
View/download PDF

7. The Importance of Frailty in the Assessment of Influenza Vaccine Effectiveness Against Influenza-Related Hospitalization in Elderly People

Author

Serious Outcomes Surveillance Network of the Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN) and the Toronto Invasive Bacterial Diseases Network (TIBDN), Andrew, Melissa K., Shinde, Vivek, Ye, Lingyun, Hatchette, Todd, Haguinet, François, Santos, Gael Dos, McElhaney, Janet E., Ambrose, Ardith, Boivin, Guy, Bowie, William, Chit, Ayman, ElSherif, May, Green, Karen, Halperin, Scott, Ibarguchi, Barbara, Johnstone, Jennie, Katz, Kevin, Langley, Joanne, Leblanc, Jason, Loeb, Mark, MacKinnon-Cameron, Donna, McCarthy, Anne, McGeer, Allison, Powis, Jeff, Richardson, David, Semret, Makeda, Stiver, Grant, Trottier, Sylvie, Valiquette, Louis, Webster, Duncan, and McNeil, Shelly A.

Published
2017

10. Contributors

Author

Abzug, Mark J., primary, Adderson, Elisabeth E., additional, Agwu, Allison L., additional, Alby, Kevin, additional, Aldrovandi, Grace M., additional, Allen, Upton D., additional, Alvarez-Hernández, Gerardo, additional, Ampofo, Krow, additional, Anderson, Evan J., additional, Anderson, Margot, additional, Antonara, Stella, additional, Ardura, Monica I., additional, Arguin, Paul M., additional, Arnold, John C., additional, Aronson, Naomi E., additional, Arvin, Ann M., additional, Ashkenazi, Shai, additional, Asturias, Edwin J., additional, Badalyan, Vahe, additional, Baker, Carol J., additional, Balakrishnan, Karthik, additional, Barros, Brittany S., additional, Barson, William J., additional, Bausch, Daniel G., additional, Bechtel, Kirsten, additional, Benjamin, Daniel K., additional, Berman, David M., additional, Blanco, David A., additional, Bloch, Karen C., additional, Blythe, Margaret J., additional, Bocchini, Joseph A., additional, Bowen, Anna, additional, Bowie, William R., additional, Boyce, Thomas G., additional, Bradley, John S., additional, Brady, Michael T., additional, Bratcher, Denise F., additional, Braverman, Paula K., additional, Bresee, Joseph, additional, Brook, Itzhak, additional, Brown, Kevin E., additional, Bryant, Kristina, additional, Buescher, E. Stephen, additional, Burns, Jane L., additional, Byington, Carrie L., additional, Camacho-Gonzalez, Andres F., additional, Cantey, Paul, additional, Carter, Bryan D., additional, Caserta, Mary T., additional, Castagnini, Luis A., additional, Cerini, Chiara, additional, Chadwick, Ellen Gould, additional, Chiang, Silvia S., additional, Christenson, John C., additional, Coffin, Susan E., additional, Collier, Melissa G., additional, Collins, Jennifer P., additional, Conklin, Laurie S., additional, Connelly, Beverly L., additional, Contopoulos-Ioannidis, Despina, additional, Conway, James H., additional, Cortese, Margaret M., additional, Cox, Elaine G., additional, Creech, C. Buddy, additional, Crews, Jonathan D., additional, Cunningham, Dennis J., additional, Curtis, Nigel, additional, Dailey, Natalie J.M., additional, Danziger-Isakov, Lara A., additional, Darville, Toni, additional, Dasch, Gregory A., additional, Daskalaki, Irini, additional, Daum, Robert S., additional, Davenport, Michael, additional, Davies, H. Dele, additional, Dawood, Fatimah S., additional, Day, J. Christopher, additional, de la Morena, Maite, additional, Demmler-Harrison, Gail J., additional, DeMuri, Gregory P., additional, Despommier, Dickson D., additional, Diefenbach, Karen A., additional, Edwards, Kathryn M., additional, Edwards, Morven S., additional, Eichenfield, Lawrence F., additional, Elston, Dirk M., additional, Emerson, Beth, additional, Ephros, Moshe, additional, Erdem, Guliz, additional, Eremeeva, Marina E., additional, Ericson, Jessica E., additional, Esposito, Douglas H., additional, Farley, Monica M., additional, Feingold, Anat R., additional, Feja, Kristina N., additional, Finn, Adam, additional, Fischer, Marc, additional, Flynn, Patricia M., additional, Fox, LeAnne M., additional, Frank, Michael M., additional, Fredrick, Douglas R., additional, Frenck, Robert W., additional, Friedlander, Sheila Fallon, additional, Gans, Hayley A., additional, Gauthier, Gregory M., additional, Gerber, Jeffrey S., additional, Gigliotti, Francis, additional, Gilger, Mark A., additional, Glaser, Carol A., additional, Goddard, Amanda F., additional, Gold, Benjamin D., additional, Gould, Jane M., additional, Green, Michael, additional, Greenberg, David, additional, Greywal, Tanya, additional, Griffin, Daniel, additional, Griffin, Patricia M., additional, Grom, Alexei A., additional, Gutierrez, Kathleen, additional, Gutman, Julie, additional, Guzman-Cottrill, Judith A., additional, Hall, Aron J., additional, Han, Jin-Young, additional, Harper, Marvin B., additional, Harris, Julie R., additional, Harrison, Christopher J., additional, Haslam, David B., additional, Hawkes, Sarah J., additional, Hendley, J. Owen, additional, Henry, Marion C.W., additional, Hilinski, Joseph A., additional, Hills, Susan L., additional, Holmberg, Scott D., additional, Holtzman, Deborah, additional, Hong, David K., additional, Hotez, Peter J., additional, Hsu, Katherine K., additional, Hunstad, David A., additional, Hwang, Loris Y., additional, Jackson, Mary Anne, additional, Jacobs, Richard F., additional, Jhaveri, Ravi, additional, Jirků-Pomajbíková, Kateřina, additional, Jones, Jeffrey L., additional, Karki, Mahima, additional, Karlowicz, M. Gary, additional, Katz, Ben Z., additional, Kaur, Ishminder, additional, Kersh, Gilbert J., additional, Keystone, Jay S., additional, Khan, Muhammad Ali, additional, Kimberlin, David W., additional, Kleiman, Martin B., additional, Klein, Bruce S., additional, Klontz, Karl, additional, Knust, Barbara, additional, Koh, Andrew Y., additional, Korgenski, E. Kent, additional, Krogstad, Paul, additional, Kutty, Preeta Krishnan, additional, Lauren, Christine T., additional, Lawrence, Hillary S., additional, Leber, Amy, additional, Lee, Grace M., additional, Leibovitz, Eugene, additional, Leshem, Eyal, additional, Levasseur, Stéphanie, additional, Lewis, David B., additional, Livingston, Robyn A., additional, Llata, Eloisa, additional, Long, Sarah S., additional, Lopman, Ben A., additional, Lucero, Yalda C., additional, Luján-Zilbermann, Jorge, additional, Luzuriaga, Katherine, additional, MacDonald, Noni E., additional, Maldonado, Yvonne A., additional, Manaloor, John, additional, Mani, Chitra S., additional, Manthiram, Kalpana, additional, Marshall, Gary S., additional, Martin, Stacey W., additional, Matanock, Almea, additional, Matiz, Catalina, additional, Mawle, Alison C., additional, Mazzulli, Tony, additional, McGann, Kathleen A., additional, McIntosh, Kenneth, additional, McNamara, Lucy A., additional, Meir, Michal, additional, Meislich, Debrah, additional, Meissner, H. Cody, additional, Meites, Elissa, additional, Mejías, Asunción, additional, Mertsola, Jussi, additional, Messacar, Kevin, additional, Mhaissen, Mohammed Nael, additional, Michaels, Marian G., additional, Miller, Melissa B., additional, Mintz, Eric D., additional, Modlin, John F., additional, Mohan, Parvathi, additional, Montgomery, Susan P., additional, Montoya, José G., additional, Moro, Pedro L., additional, Moscicki, Anna-Barbara, additional, Moss, R. Lawrence, additional, Myers, Angela L., additional, Nadel, Simon, additional, Neely, Michael N., additional, Neil, Karen P., additional, Nelson, Joanna, additional, Nelson, Noele P., additional, Nicholson, William L., additional, Nizet, Victor, additional, Nopper, Amy Jo, additional, Ochoa, Theresa J., additional, Orenstein, Walter A., additional, O'Ryan, Miguel, additional, Paddock, Christopher D., additional, Pall, Harpreet, additional, Panuganti, Suresh Kumar, additional, Pappas, Diane E., additional, Pass, Robert F., additional, Patterson, Thomas F., additional, Patton, Monica E., additional, Pelton, Stephen I., additional, Petersen, Brett W., additional, Pickering, Larry K., additional, Pinninti, Swetha, additional, Planet, Paul J., additional, Pollard, Andrew J., additional, Posfay-Barbe, Klara M., additional, Poulsen, Casper S., additional, Poutanen, Susan M., additional, Powers, Ann M., additional, Prober, Charles G., additional, Ramilo, Octavio, additional, Rangel, Shawn J., additional, Rao, Suchitra, additional, Rawstron, Sarah A., additional, Read, Jennifer S., additional, Reed, Michael D., additional, Relich, Ryan F., additional, Reller, Megan E., additional, Rellosa, Neil, additional, Rempe, Katherine A., additional, Reyes, Melissa A., additional, Rice-Townsend, Samuel E., additional, Richards, Frank O., additional, Romero, José R., additional, Rosen, David A., additional, Rostad, Christina A., additional, Rours, G. Ingrid J.G., additional, Routh, Janell A., additional, Rowley, Anne H., additional, Rubin, Lorry G., additional, Ryan, Edward T., additional, Saiman, Lisa, additional, Sammons, Julia S., additional, Sass, Laura, additional, Sauberan, Jason B., additional, Schillie, Sarah, additional, Schulert, Grant S., additional, Schuster, Jennifer E., additional, Schwartz, Kevin L., additional, Sederdahl, Bethany K., additional, Serpa, Jose A., additional, Shah, Kara N., additional, Shah, Samir S., additional, Shane, Andi L., additional, Shapiro, Eugene D., additional, Shaw, Jana, additional, Shetty, Avinash K., additional, Dairiki, Linda M., additional, Siberry, George Kelly, additional, Siegel, Jane D., additional, Siegel, Robert David, additional, Simonsen, Kari A., additional, Singh, Nalini, additional, Singh, Upinder, additional, Smith, P. Brian, additional, Snyder, John D., additional, Song, Eunkyung, additional, Sorrell, Jennifer L., additional, Souder, Emily, additional, St. Geme, Joseph W., additional, Staat, Mary Allen, additional, Staples, J. Erin, additional, Starke, Jeffrey R., additional, Steinbach, William J., additional, Stensvold, Christen R., additional, Stoner, Bradley P., additional, Strikas, Raymond A., additional, Strober, Jonathan B., additional, Sue, Paul K., additional, Sutton, Deanna A., additional, Swanson, Douglas, additional, Tate, Jacqueline E., additional, Tebruegge, Marc, additional, Teshale, Eyasu H., additional, Thompson, Amelia B., additional, Thompson, George R., additional, Thompson-Stone, Robert, additional, Thomson, Richard B., additional, Thorell, Emily A., additional, Tobin, Nicole H., additional, Toltzis, Philip, additional, Treat, James, additional, Troy, Stephanie B., additional, Van, Russell B., additional, Vaz, Louise Elaine, additional, Vodzak, Jennifer, additional, Wald, Ellen R., additional, Wallihan, Rebecca, additional, Wangu, Zoon, additional, Washam, Matthew, additional, Watson, Joshua R., additional, Wattier, Rachel L., additional, Weinberg, Geoffrey A., additional, White, A. Clinton, additional, Wiesenfeld, Harold C., additional, Williams, John V., additional, Willoughby, Rodney E., additional, Wingerter, Sarah L., additional, Wittler, Robert R., additional, Wong, Karen K., additional, Workowski, Kimberly A., additional, Wright, Terry W., additional, Yagupsky, Pablo, additional, Yen, Catherine, additional, Yi, Jumi, additional, Yoder, Jonathan S., additional, Young, Edward J., additional, Zaenglein, Andrea L., additional, and Zimmerman, Kanecia, additional

Published
2018
Full Text
View/download PDF

11. Longitudinal Clinical Findings and Outcome Among Patients With Cryptococcus gattii Infection in British Columbia

Author

British Columbia Cryptococcus gattii Study Group, Phillips, Peter, Galanis, Eleni, MacDougall, Laura, Chong, Mei Y., Balshaw, Robert, Cook, Victoria J., Bowie, William, Steiner, Theodore, Hoang, Linda, Morshed, Muhammad, Ghesquiere, Wayne, Forrest, David M., Roscoe, Diane, Doyle, Patrick, Kibsey, Pamela C., Connolly, Thomas, Mirzanejad, Yazdan, and Thompson, Darby

Published
2015
Full Text
View/download PDF

12. Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness.

Author

ElSherif, May, Andrew, Melissa K, Ye, Lingyun, Ambrose, Ardith, Boivin, Guy, Bowie, William, David, Marie-Pierre, Gruselle, Olivier, Halperin, Scott A, Hatchette, Todd F, Johnstone, Jennie, Katz, Kevin, Langley, Joanne M, Loeb, Mark, MacKinnon-Cameron, Donna, McCarthy, Anne, McElhaney, Janet E, McGeer, Allison, Poirier, Andre, and Pirçon, Jean-Yves

Subjects
RESPIRATORY syncytial virus infections, ACUTE flaccid paralysis, ACUTE diseases, INFLUENZA viruses, HUMAN metapneumovirus infection, OLDER people, LENGTH of stay in hospitals
Abstract

Background Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50 years hospitalized with RSV. Methods Using administrative data and nasopharyngeal swabs collected from active surveillance among adults aged ≥50 years hospitalized with an acute respiratory illness (ARI) during the 2012–2013, 2013–2014, and 2014–2015 influenza seasons, RSV was identified using a respiratory virus multiplex polymerase chain reaction test to describe the associated disease burden, incidence, and healthcare costs. Results Of 7797 patients tested, 371 (4.8%) were RSV positive (2.2% RSV-A and 2.6% RSV-B). RSV prevalence varied by season from 4.2% to 6.2%. Respiratory virus coinfection was observed in 11.6% (43/371) of RSV cases, with influenza A being the most common. RSV hospitalization rates varied between seasons and increased with age, from 8–12 per 100 000 population in adults aged 50–59 years to 174–487 per 100 000 in adults aged ≥80 years. The median age of RSV cases was 74.9 years, 63.7% were female, and 98.1% of cases had ≥1 comorbidity. Among RSV cases, the mean length of hospital stay was 10.6 days, 13.7% were admitted to the intensive care unit, 6.4% required mechanical ventilation, and 6.1% died. The mean cost per RSV case was $13 602 (Canadian dollars) but varied by age and Canadian province. Conclusions This study adds to the growing literature on adult RSV burden by showing considerable morbidity, mortality, and healthcare costs in hospitalized adults aged ≥50 years with ARIs such as influenza. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

16. Recalibrated estimates of non-bacteremic and bacteremic pneumococcal community acquired pneumonia in hospitalized Canadian adults from 2010 to 2017 with addition of an extended spectrum serotype-specific urine antigen detection assay

Author

LeBlanc, Jason J., primary, ElSherif, May, additional, Ye, Lingyun, additional, MacKinnon-Cameron, Donna, additional, Ambrose, Ardith, additional, Hatchette, Todd F., additional, Lang, Amanda L.S., additional, Gillis, Hayley D., additional, Martin, Irene, additional, Demczuk, Walter H.B., additional, Andrew, Melissa K., additional, Boivin, Guy, additional, Bowie, William, additional, Green, Karen, additional, Johnstone, Jennie, additional, Loeb, Mark, additional, McCarthy, Anne E., additional, McGeer, Allison, additional, Semret, Makeda, additional, Trottier, Sylvie, additional, Valiquette, Louis, additional, Webster, Duncan, additional, and McNeil, Shelly A., additional

Published
2022
Full Text
View/download PDF

19. 1325. Recalibrating Estimates of Pneumococcal Disease in Hospitalized Canadian adults from 2010 to 2017 with Use of an Extended Spectrum Serotype-specific Urine Antigen Detection

Author

LeBlanc, Jason J, primary, ElSherif, May, additional, Ye, Lingyun, additional, MacKinnon-Cameron, Donna, additional, Ambrose, Ardith, additional, Hatchette, Todd F, additional, Lang, Amanda L S, additional, Gillis, Hayley D, additional, Martin, Irene, additional, Demczuk, Walter, additional, Andrew, Melissa K, additional, Boivin, Guy, additional, Bowie, William, additional, Green, Karen, additional, Johnstone, Jennie, additional, Loeb, Mark, additional, McCarthy, Anne, additional, McGeer, Allison, additional, Semret, Makeda, additional, Trottier, Sylvie, additional, Valiquette, Louis, additional, Webster, Duncan, additional, and McNeil, Shelly, additional

Published
2021
Full Text
View/download PDF

31. Round Table Discussion

Author

Lane, Alfred C., Bowie, William, Dickerson, Roy E., Eckhardt, E. A., Garner, C. L., Hobbs, W. H., Humphreys, W. J., Longwell, Chester R., Russell, H. N., Smith, Paul S., Thom,, W. T., and Vaughan, T. W.

Published
1938

38. Isostasy

Author

Bowie, William

Published
1935

40. Isostasy

Author

Bowie, William

Published
1937

48. Antibiotic use in children is associated with increased risk of asthma

Author

Marra, Fawziah, Marra, Carlo A., Richardson, Kathryn, Lynd, Larry D., Kozyrskyj, Anita, Patrick, David M., Bowie, William R., and FitzGerald, J. Mark

Subjects
Asthma in children -- Risk factors, Asthma in children -- Drug therapy, Antibiotics -- Usage, Antibiotics -- Health aspects, Drug therapy -- Usage, Drug therapy -- Patient outcomes
Published
2009

50. Establishing a community of practice of researchers, practitioners, policy-makers and communities to sustainably manage environmental health risks in Ecuador

Author

Henry Bonnie, Orrego Elena, Rojas Alejandro, Yassi Annalee, Parra Jorge, Solis Fernanda, Beltran Efrain, Breilh Jaime, Spiegel Jerry M, Bowie William R, Pearce Laurie, Gaibor Juan, Velasquez Patricio, Concepcion Miriam, and Parkes Margot

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background The Sustainably Managing Environmental Health Risk in Ecuador project was launched in 2004 as a partnership linking a large Canadian university with leading Cuban and Mexican institutes to strengthen the capacities of four Ecuadorian universities for leading community-based learning and research in areas as diverse as pesticide poisoning, dengue control, water and sanitation, and disaster preparedness. Methods In implementing curriculum and complementary innovations through application of an ecosystem approach to health, our interdisciplinary international team focused on the question: “Can strengthening of institutional capacities to support a community of practice of researchers, practitioners, policy-makers and communities produce positive health outcomes and improved capacities to sustainably translate knowledge?” To assess progress in achieving desired outcomes, we review results associated with the logic framework analysis used to guide the project, focusing on how a community of practice network has strengthened implementation, including follow-up tracking of program trainees and presentation of two specific case studies. Results By 2009, train-the-trainer project initiation involved 27 participatory action research Master’s theses in 15 communities where 1200 community learners participated in the implementation of associated interventions. This led to establishment of innovative Ecuadorian-led master’s and doctoral programs, and a Population Health Observatory on Collective Health, Environment and Society for the Andean region based at the Universidad Andina Simon Bolivar. Building on this network, numerous initiatives were begun, such as an internationally funded research project to strengthen dengue control in the coastal community of Machala, and establishment of a local community eco-health centre focusing on determinants of health near Cuenca. Discussion Strengthening capabilities for producing and applying knowledge through direct engagement with affected populations and decision-makers provides a fertile basis for consolidating capacities to act on a larger scale. This can facilitate the capturing of benefits from the “top down” (in consolidating institutional commitments) and the “bottom up” (to achieve local results). Conclusions Alliances of academic and non-academic partners from the South and North provide a promising orientation for learning together about ways of addressing negative trends of development. Assessing the impacts and sustainability of such processes, however, requires longer term monitoring of results and related challenges.

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results