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4. Point-of-Care Antigen Test for SARS-CoV-2 in Asymptomatic College Students

Author

Tinker, Sarah C., Szablewski, Christine M., Litvintseva, Anastasia P., Drenzek, Cherie, Voccio, Gary E., Hunter, Melissa A., Briggs, Stephen, Heida, Debbie E., Folster, Jennifer, Shewmaker, Patricia L., Medrzycki, Magdalena, Bowen, Michael D., Bohannon, Caitlin, Bagarozzi, Dennis, Jr., Petway, Marla, Rota, Paul A., Kuhnert-Tallman, Wendi, Thornburg, Natalie, Prince-Guerra, Jessica L., Barrios, Lisa C., Tamin, Azaibi, Harcourt, Jennifer L., and Honein, Margaret A.

Subjects
College students -- Medical examination, Antigens -- Health aspects, Health
Abstract

Point-of-care antigen testing provides results more quickly than real-time reverse transcription PCR (rRT-PCR). In August 2020, the US Food and Drug Administration granted emergency use authorization to the BinaxNOW COVID-19 [...]

Published
2021
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8. Effects of Patient Characteristics on Diagnostic Performance of Self-Collected Samples for SARS-CoV-2 Testing

Author

Smith-Jeffcoat, Sarah E., Koh, Mitsuki, Hoffman, Adam, Rebolledo, Paulina A., Schechter, Marcos C., Miller, Halie K., Sleweon, Sadia, Rossetti, Rebecca, Kasinathan, Vyjayanti, Shragai, Talya, O'Laughlin, Kevin, Espinosa, Catherine C., Khalil, George M., Adeyemo, AdeSubomi O., Moorman, Anne, Bauman, Brenda L., Joseph, Kahaliah, O'Hegarty, Michelle, Kamal, Nazia, Atallah, Hany, Moore, Brooks L., Bohannon, Caitlin D., Bankamp, Bettina, Hartloge, Claire, Bowen, Michael D., Paulick, Ashley, Gargis, Amy S., Elkins, Christopher, Stewart, Rebekah J., da Silva, Juliana, Biedron, Caitlin, Tate, Jacqueline E., Wang, Yun F., and Kirking, Hannah L.

Subjects
Self-examination, Medical -- Methods, Medical testing products -- Usage, Health
Abstract

Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease (COVID-19), originally relied mainly on nasopharyngeal swab (NPS) samples collected by healthcare workers (HCWs). However, [...]

Published
2021
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9. Correlates of Rotavirus Vaccine Shedding and Seroconversion in a US Cohort of Healthy Infants.

Author

Burke, Rachel M, Payne, Daniel C, McNeal, Monica, Conrey, Shannon C, Burrell, Allison R, Mattison, Claire P, Casey-Moore, Mary C, Mijatovic-Rustempasic, Slavica, Gautam, Rashi, Esona, Mathew D, Thorman, Alexander W, Bowen, Michael D, Parashar, Umesh D, Tate, Jacqueline E, Morrow, Ardythe L, and Staat, Mary A

Subjects
ROTAVIRUS vaccines, VACCINE immunogenicity, VACCINE effectiveness, GENERALIZED estimating equations, VIRAL vaccines
Abstract

Background Rotavirus is a leading cause of severe pediatric gastroenteritis; 2 highly effective vaccines are used in the United States (US). We aimed to identify correlates of immune response to rotavirus vaccination in a US cohort. Methods Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis Longitudinal (PREVAIL) is a birth cohort of 245 mother-child pairs enrolled in 2017–2018 and followed for 2 years. Infant stool samples and symptom information were collected weekly. Shedding was defined as reverse-transcription polymerase chain reaction detection of rotavirus vaccine virus in stools collected 4–28 days after dose 1. Seroconversion was defined as a 3-fold rise in immunoglobulin A between the 6-week and 6-month blood draws. Correlates were analyzed using generalized estimating equations and logistic regression. Results Prevaccination immunoglobulin G (IgG) (odds ratio [OR], 0.84 [95% confidence interval {CI},.75–.94] per 100-unit increase) was negatively associated with shedding. Shedding was also less likely among infants with a single-nucleotide polymorphism inactivating FUT2 antigen secretion ("nonsecretors") with nonsecretor mothers, versus all other combinations (OR, 0.37 [95% CI,.16–.83]). Of 141 infants with data, 105 (74%) seroconverted; 78 (77%) had shed vaccine virus following dose 1. Prevaccination IgG and secretor status were significantly associated with seroconversion. Neither shedding nor seroconversion significantly differed by vaccine product. Conclusions In this US cohort, prevaccination IgG and maternal and infant secretor status were associated with rotavirus vaccine response. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Understanding Variation in Rotavirus Vaccine Effectiveness Estimates in the United States: The Role of Rotavirus Activity and Diagnostic Misclassification

Author

Amin, Avnika B., Lash, Timothy L., Tate, Jacqueline E., Waller, Lance A., Wikswo, Mary E., Parashar, Umesh D., Stewart, Laura S., Chappell, James D., Halasa, Natasha B., Williams, John V., Michaels, Marian G., Hickey, Robert W., Klein, Eileen J., Englund, Janet A., Weinberg, Geoffrey A., Szilagyi, Peter G., Staat, Mary Allen, McNeal, Monica M., Boom, Julie A., Sahni, Leila C., Selvarangan, Rangaraj, Harrison, Christopher J., Moffatt, Mary E., Schuster, Jennifer E., Pahud, Barbara A., Weddle, Gina M., Azimi, Parvin H., Johnston, Samantha H., Payne, Daniel C., Bowen, Michael D., and Lopman, Benjamin A.

Published
2022
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11. Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008–2013

Author

Bowen, Michael D, Mijatovic-Rustempasic, Slavica, Esona, Mathew D, Teel, Elizabeth N, Gautam, Rashi, Sturgeon, Michele, Azimi, Parvin H, Baker, Carol J, Bernstein, David I, Boom, Julie A, Chappell, James, Donauer, Stephanie, Edwards, Kathryn M, Englund, Janet A, Halasa, Natasha B, Harrison, Christopher J, Johnston, Samantha H, Klein, Eileen J, McNeal, Monica M, Moffatt, Mary E, Rench, Marcia A, Sahni, Leila C, Selvarangan, Rangaraj, Staat, Mary A, Szilagyi, Peter G, Weinberg, Geoffrey A, Wikswo, Mary E, Parashar, Umesh D, and Payne, Daniel C

Subjects
Prevention, Vaccine Related, Clinical Research, Pediatric, Immunization, Infectious Diseases, Good Health and Well Being, Child, Child, Preschool, Epidemiological Monitoring, Female, Genotype, Humans, Infant, Male, Rotavirus, Rotavirus Infections, Rotavirus Vaccines, United States, rotavirus, genotype, prevalence, surveillance, vaccine, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundGroup A rotaviruses (RVA) are a significant cause of pediatric gastroenteritis worldwide. The New Vaccine Surveillance Network (NVSN) has conducted active surveillance for RVA at pediatric hospitals and emergency departments at 3-7 geographically diverse sites in the United States since 2006.MethodsOver 6 consecutive years, from 2008 to 2013, 1523 samples from NVSN sites that were tested positive by a Rotaclone enzyme immunoassay were submitted to the Centers for Disease Control and Prevention for genotyping.ResultsIn the 2009, 2010, and 2011 seasons, genotype G3P[8] was the predominant genotype throughout the network, with a 46%-84% prevalence. In the 2012 season, G12P[8] replaced G3P[8] as the most common genotype, with a 70% prevalence, and this trend persisted in 2013 (68.0% prevalence). Vaccine (RotaTeq; Rotarix) strains were detected in 0.6%-3.4% of genotyped samples each season. Uncommon and unusual strains (eg, G8P[4], G3P[24], G2P[8], G3P[4], G3P[6], G24P[14], G4P[6], and G9P[4]) were detected sporadically over the study period. Year, study site, and race were found to be significant predictors of genotype.ConclusionsContinued active surveillance is needed to monitor RVA genotypes in the United States and to detect potential changes since vaccine licensure.

Published
2016

12. Long-term Consistency in Rotavirus Vaccine Protection: RV5 and RV1 Vaccine Effectiveness in US Children, 2012–2013

Author

Payne, Daniel C, Selvarangan, Rangaraj, Azimi, Parvin H, Boom, Julie A, Englund, Janet A, Staat, Mary Allen, Halasa, Natasha B, Weinberg, Geoffrey A, Szilagyi, Peter G, Chappell, James, McNeal, Monica, Klein, Eileen J, Sahni, Leila C, Johnston, Samantha H, Harrison, Christopher J, Baker, Carol J, Bernstein, David I, Moffatt, Mary E, Tate, Jacqueline E, Mijatovic-Rustempasic, Slavica, Esona, Mathew D, Wikswo, Mary E, Curns, Aaron T, Sulemana, Iddrisu, Bowen, Michael D, Gentsch, Jon R, and Parashar, Umesh D

Subjects
Prevention, Health Services, Immunization, Infectious Diseases, Patient Safety, Clinical Research, Vaccine Related, Pediatric, Digestive Diseases, 3.4 Vaccines, Prevention of disease and conditions, and promotion of well-being, Infection, Antigens, Viral, Child, Child, Preschool, Emergency Medical Services, Enzyme-Linked Immunosorbent Assay, Epidemiological Monitoring, Feces, Female, Gastroenteritis, Genotype, Hospitalization, Humans, Infant, Male, RNA, Viral, Rotavirus Infections, Rotavirus Vaccines, Treatment Outcome, United States, Vaccines, Attenuated, rotavirus vaccine, RV1-Rotarix, RV5-RotaTeq, acute gastroenteritis, surveillance, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundUsing a multicenter, active surveillance network from 2 rotavirus seasons (2012 and 2013), we assessed the vaccine effectiveness of RV5 (RotaTeq) and RV1 (Rotarix) rotavirus vaccines in preventing rotavirus gastroenteritis hospitalizations and emergency department (ED) visits for numerous demographic and secular strata.MethodsWe enrolled children hospitalized or visiting the ED with acute gastroenteritis (AGE) for the 2012 and 2013 seasons at 7 medical institutions. Stool specimens were tested for rotavirus by enzyme immunoassay and genotyped, and rotavirus vaccination histories were compared for rotavirus-positive cases and rotavirus-negative AGE controls. We calculated the vaccine effectiveness (VE) for preventing rotavirus associated hospitalizations and ED visits for each vaccine, stratified by vaccine dose, season, clinical setting, age, predominant genotype, and ethnicity.ResultsRV5-specific VE analyses included 2961 subjects, 402 rotavirus cases (14%) and 2559 rotavirus-negative AGE controls. RV1-specific VE analyses included 904 subjects, 100 rotavirus cases (11%), and 804 rotavirus-negative AGE controls. Over the 2 rotavirus seasons, the VE for a complete 3-dose vaccination with RV5 was 80% (confidence interval [CI], 74%-84%), and VE for a complete 2-dose vaccination with RV1 was 80% (CI, 68%-88%).Statistically significant VE was observed for each year of life for which sufficient data allowed analysis (7 years for RV5 and 3 years for RV1). Both vaccines provided statistically significant genotype-specific protection against predominant circulating rotavirus strains.ConclusionsIn this large, geographically and demographically diverse sample of US children, we observed that RV5 and RV1 rotavirus vaccines each provided a lasting and broadly heterologous protection against rotavirus gastroenteritis.

Published
2015

17. The CDC Domestic Mpox Response--United States, 2022-2023

Author

McQuiston, Jennifer H., Braden, Christopher R., Bowen, Michael D., McCollum, Andrea M., McDonald, Robert, Carnes, Neal, Carter, Rosalind J., Christie, Athalia, Doty, Jeffrey B., Ellington, Sascha, Fehrenbach, S. Nicole, Gundlapalli, Adi V., Hutson, Christina L., Kachur, Rachel E., Maitland, Aaron, Pearson, Christine M., Prejean, Joseph, Quilter, Laura A.S., Rao, Agam K., Yu, Yon, and Mermin, Jonathan

Subjects
United States. Food and Drug Administration, United States. Department of Health and Human Services, Social service, Zoonoses, Public health, Health, World Health Organization
Abstract

Monkeypox (mpox) is a serious viral zoonosis endemic in west and central Africa. An unprecedented global outbreak was first detected in May 2022. CDC activated its emergency outbreak response on [...]

Published
2023

18. Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network

Author

Antoni, Sebastien, primary, Nakamura, Tomoka, additional, Cohen, Adam L., additional, Mwenda, Jason M., additional, Weldegebriel, Goitom, additional, Biey, Joseph N. M., additional, Shaba, Keith, additional, Rey-Benito, Gloria, additional, de Oliveira, Lucia Helena, additional, Oliveira, Maria Tereza da Costa, additional, Ortiz, Claudia, additional, Ghoniem, Amany, additional, Fahmy, Kamal, additional, Ashmony, Hossam A., additional, Videbaek, Dovile, additional, Daniels, Danni, additional, Pastore, Roberta, additional, Singh, Simarjit, additional, Tondo, Emmanuel, additional, Liyanage, Jayantha B. L., additional, Sharifuzzaman, Mohammed, additional, Grabovac, Varja, additional, Batmunkh, Nyambat, additional, Logronio, Josephine, additional, Armah, George, additional, Dennis, Francis E., additional, Seheri, Mapaseka, additional, Magagula, Nonkululeko, additional, Mphahlele, Jeffrey, additional, Leite, Jose Paulo G., additional, Araujo, Irene T., additional, Fumian, Tulio M., additional, EL Mohammady, Hanan, additional, Semeiko, Galina, additional, Samoilovich, Elena, additional, Giri, Sidhartha, additional, Kang, Gagandeep, additional, Thomas, Sarah, additional, Bines, Julie, additional, Kirkwood, Carl D., additional, Liu, Na, additional, Lee, Deog-Yong, additional, Iturriza-Gomara, Mirren, additional, Page, Nicola Anne, additional, Esona, Mathew D., additional, Ward, M. Leanne, additional, Wright, Courtnee N., additional, Mijatovic-Rustempasic, Slavica, additional, Tate, Jacqueline E., additional, Parashar, Umesh D., additional, Gentsch, Jon, additional, Bowen, Michael D., additional, and Serhan, Fatima, additional

Published
2023
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20. Three Rotavirus Outbreaks in the Postvaccine Era — California, 2017

Author

Burke, Rachel M., Tate, Jacqueline E., Barin, Nora, Bock, Carly, Bowen, Michael D., Chang, David, Gautam, Rashi, Han, George, Holguin, John, Huynh, Thalia, Pan, Chao-Yang, Quenelle, Rebecca, Sallenave, Catherine, Torres, Cindy, Wadford, Debra, and Parashar, Umesh

Published
2018

21. Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis in US Mothers and Children Aged 0-2: PREVAIL Cohort Study

Author

Morrow, Ardythe L, Staat, Mary A, DeFranco, Emily A, McNeal, Monica M, Cline, Allison R, Conrey, Shannon C, Schlaudecker, Elizabeth P, Piasecki, Alexandra M, Burke, Rachel M, Niu, Liang, Hall, Aron J, Bowen, Michael D, Gerber, Susan I, Langley, Gayle E, Thornburg, Natalie J, Campbell, Angela P, Vinjé, Jan, Parashar, Umesh D, and Payne, Daniel C

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundAcute gastroenteritis (AGE) and acute respiratory infections (ARIs) cause significant pediatric morbidity and mortality. Developing childhood vaccines against major enteric and respiratory pathogens should be guided by the natural history of infection and acquired immunity. The United States currently lacks contemporary birth cohort data to guide vaccine development. ObjectiveThe PREVAIL (Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis Longitudinal) Cohort study was undertaken to define the natural history of infection and immune response to major pathogens causing AGE and ARI in US children. MethodsMothers in Cincinnati, Ohio, were enrolled in their third trimester of pregnancy, with intensive child follow-up to 2 years. Blood samples were obtained from children at birth (cord), 6 weeks, and 6, 12, 18, and 24 months. Whole stool specimens and midturbinate nasal swabs were collected weekly and tested by multipathogen molecular assays. Saliva, meconium, maternal blood, and milk samples were also collected. AGE (≥3 loose or watery stools or ≥1 vomiting episode within 24 hours) and ARI (cough or fever) cases were documented by weekly cell phone surveys to mothers via automated SMS text messaging and review of medical records. Immunization records were obtained from registries and providers. follow-up ended in October 2020. Pathogen-specific infections are defined by a PCR-positive sample or rise in serum antibody. ResultsOf the 245 enrolled mother–child pairs, 51.8% (n=127) were White, 43.3% (n=106) Black, 55.9% (n=137) publicly insured, and 86.5% (n=212) initiated breastfeeding. Blood collection was 100.0% for mothers (n=245) and 85.7% for umbilical cord (n=210). A total of 194/245 (79.2%) mother–child pairs were compliant based on participation in at least 70% (≥71/102 study weeks) of child-weeks and providing 70% or more of weekly samples during that time, or blood samples at 18 or 24 months. Compliant participants (n=194) had 71.0% median nasal swab collection (IQR 30.0%-90.5%), with 98.5% (191/194) providing either an 18- or 24-month blood sample; median response to weekly SMS text message surveys was 95.1% (IQR 76.5%-100%). Compliant mothers reported 2.0 AGE and 4.5 ARI cases per child-year, of which 25.5% (160/627) and 38.06% (486/1277) of cases, respectively, were medically attended; 0.5% of AGE (3/627) and 0.55% of ARI (7/1277) cases were hospitalized. ConclusionsThe PREVAIL Cohort demonstrates intensive follow-up to document the natural history of enteric and respiratory infections and immunity in children 0-2 years of age in the United States and will contribute unique data to guide vaccine recommendations. Testing for pathogens and antibodies is ongoing. International Registered Report Identifier (IRRID)RR1-10.2196/22222

Published
2021
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25. Whole genome and in-silico analyses of G1P[8] rotavirus strains from pre- and post-vaccination periods in Rwanda

Author

Rasebotsa, Sebotsana, Mwangi, Peter N., Mogotsi, Milton T., Sabiu, Saheed, Magagula, Nonkululeko B., Rakau, Kebareng, Uwimana, Jeannine, Mutesa, Leon, Muganga, Narcisse, Murenzi, Didier, Tuyisenge, Lisine, Jaimes, Jose, Esona, Mathew D., Bowen, Michael D., Mphahlele, M. Jeffrey, Seheri, Mapaseka L., Mwenda, Jason M., and Nyaga, Martin M.

Published
2020
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26. Detection of Rotavirus in Respiratory Specimens From Bangladeshi Children Aged <2 Years Hospitalized for Acute Gastroenteritis.

Author

Satter, Syed Moinuddin, Katz, Eric, Hossain, Mohammad Enayet, Fariha, Farzana, Talha, Muhammad, Smart, Sarah L, Bowen, Michael D, Rahman, Mustafizur, Parashar, Umesh D, and Cortese, Margaret M

Subjects
ROTAVIRUSES, GASTROENTERITIS, GENOTYPES, RNA, AGE
Abstract

To examine the potential for respiratory transmission of rotavirus, we systematically assessed if rotavirus RNA is detectable by real-time quantitative reverse transcription-polymerase chain reaction from nasal and oropharyngeal swab specimens of Bangladeshi children with acute rotavirus gastroenteritis. Forehead swabs were collected to assess skin contamination. Among 399 children aged <2 years hospitalized for gastroenteritis during peak rotavirus season, rotavirus RNA was detected in stool, oral, nasal and forehead swab specimens of 354 (89%). A subset was genotyped; genotype was concordant within a child's specimen set and several different genotypes were detected across children. These findings support possible respiratory transmission of rotavirus and warrant further investigation. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Histo-Blood Group Antigen Null Phenotypes Associated With a Decreased Risk of Clinical Rotavirus Vaccine Failure Among Children &lt;2 Years of Age Participating in the Vaccine Impact on Diarrhea in Africa (VIDA) Study in Kenya, Mali, and the Gambia

Author

Schwartz, Lauren M, primary, Oshinsky, Jennifer, additional, Reymann, Mardi, additional, Esona, Mathew D, additional, Bowen, Michael D, additional, Jahangir Hossain, M, additional, Zaman, Syed M A, additional, Jones, Joquina Chiquita M, additional, Antonio, Martin, additional, Badji, Henry, additional, Sarwar, Golam, additional, Sow, Samba O, additional, Sanogo, Doh, additional, Keita, Adama Mamby, additional, Tamboura, Boubou, additional, Traoré, Awa, additional, Onwuchekwa, Uma, additional, Omore, Richard, additional, Verani, Jennifer R, additional, Awuor, Alex O, additional, Ochieng, John B, additional, Juma, Jane, additional, Ogwel, Billy, additional, Parashar, Umesh D, additional, Tate, Jacqueline E, additional, Kasumba, Irene N, additional, Tennant, Sharon M, additional, Neuzil, Kathleen M, additional, Rowhani-Rahbar, Ali, additional, Elizabeth Halloran, M, additional, Atmar, Robert L, additional, Pasetti, Marcela F, additional, and Kotloff, Karen L, additional

Published
2023
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33. Ebola Virus Disease Diagnostics, Sierra Leone: Analysis of Real-time Reverse Transcription-Polymerase Chain Reaction Values for Clinical Blood and Oral Swab Specimens

Author

Erickson, Bobbie R., Sealy, Tara K., Flietstra, Tim, Morgan, Laura, Kargbo, Brima, Matt-Lebby, Victor E., Gibbons, Aridth, Chakrabarti, Ayan K., Graziano, James, Presser, Lance, Flint, Mike, Bird, Brian H., Brown, Shelley, Klena, John D., Blau, Dianna M., Brault, Aaron C., Belser, Jessica A., Salzer, Johanna S., Schuh, Amy J., Lo, Michael, Zivcec, Marko, Priestley, Rachael A., Pyle, Meredith, Goodman, Christin, Bearden, Scott, Amman, Brian R., Basile, Alison, Bergeron, Éric, Bowen, Michael D., McMullan, Laura K., Paddock, Christopher D., Russell, Brandy J., Sanchez, Angela J., Towner, Jonathan S., Wang, David, Zemtsova, Galina E., Stoddard, Robyn A., Turnsek, Maryann, Guerrero, Lisa Wiggleton, Emery, Shannon L., Stovall, Janae, Kainulainen, Markus H., Perniciaro, Jamie L., Mijatovic-Rustempasic, Slavica, Shakirova, Gulchekhra, Winter, Jörn, Sexton, Christopher, Liu, Feng, Slater, Kimetha, Anderson, Raydel, Andersen, Lauren, Chiang, Cheng-Feng, Tzeng, Wen-Pin, Crowe, Samuel J., Maenner, Matthew J., Spiropoulou, Christina F., Nichol, Stuart T., and Ströher, Ute

Published
2016

36. Role of Pre-Farrow Natural Planned Exposure of Gilts in Shaping the Passive Antibody Response to Rotavirus A in Piglets.

Author

Kumar, Deepak, Anderson Reever, Amanda V., Pittman, Jeremy S., Springer, Nora L., Mallen, Kylynn, Roman-Sosa, Gleyder, Sangewar, Neha, Casey-Moore, Mary C., Bowen, Michael D., Mwangi, Waithaka, and Marthaler, Douglas G.

Subjects
ANTIBODY formation, PIGLETS, ANIMAL herds, SOWS, ROTAVIRUSES
Abstract

Natural planned exposure (NPE) remains one of the most common methods in swine herds to boost lactogenic immunity against rotaviruses. However, the efficacy of NPE protocols in generating lactogenic immunity has not been investigated before. A longitudinal study was conducted to investigate the dynamics of genotype-specific antibody responses to different doses (3, 2 and 1) of Rotavirus A (RVA) NPE (genotypes G4, G5, P[7] and P[23]) in gilts and the transfer of lactogenic immunity to their piglets. Group 1 gilts received three doses of NPE at 5, 4 and 3 weeks pre-farrow (WPF), group 2 received two doses at 5 and 3 WPF, group 3 received one dose at 5 WPF, and group 4 received no NPE (control group). VP7 (G4 and G5) and truncated VP4* (P[7] and P[23]) antigens of RVA were expressed in mammalian and bacterial expression systems, respectively, and used to optimize indirect ELISAs to determine antibody levels against RVA in gilts and piglets. In day-0 colostrum samples, group 1 had significantly higher IgG titers compared to the control group for all four antigens, and either significantly or numerically higher IgG titers than groups 2 and 3. Group 1 also had significantly higher colostrum IgA levels than the control group for all antigens (except G4), and either significantly or numerically higher IgA levels compared to groups 2 and 3. In piglet serum, group 1 piglets had higher IgG titers for all four antigens at day 0 than the other groups. Importantly, RVA NPE stimulated antibodies in all groups regardless of the treatment doses and prevented G4, G5, P[7] and P[23] RVA fecal shedding prior to weaning in piglets in the absence of viral challenge. The G11 and P[34] RVA genotypes detected from pre-weaning piglets differed at multiple amino acid positions with parent NPE strains. In conclusion, the results of this study suggest that the group 1 NPE regimen (three doses of NPE) resulted in the highest anti-RVA antibody (IgG and IgA) levels in the colostrum/milk, and the highest IgG levels in piglet serum. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Estimation of Rotavirus Vaccine Effectiveness Based on Whole Genome Sequences

Author

Chappell, James D., primary, Williams, John, additional, Weinberg, Geoffrey, additional, Bowen, Michael D., additional, Kwon, Jiye, additional, Pitzer, Virginia E., additional, Jaimes, Jose, additional, Wikswo, Mary, additional, Klein, Eileen J., additional, Staat, Mary Allen, additional, Harrison, Christopher J., additional, Selvarangan, Rangaraj, additional, Johnson, Coreen, additional, and Esona, Mathew, additional

Published
2023
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41. Ebola Virus Diagnostics: The US Centers for Disease Control and Prevention Laboratory in Sierra Leone, August 2014 to March 2015

Author

Flint, Mike, Goodman, Christin H., Bearden, Scott, Blau, Dianna M., Amman, Brian R., Basile, Alison J., Belser, Jessica A., Bergeron, Éric, Bowen, Michael D., Brault, Aaron C., Campbell, Shelley, Chakrabarti, Ayan K., Dodd, Kimberly A., Erickson, Bobbie R., Freeman, Molly M., Gibbons, Aridth, Guerrero, Lisa W., Klena, John D., Lash, R. Ryan, Lo, Michael K., McMullan, Laura K., Momoh, Gbetuwa, Massally, James L., Goba, Augustine, Paddock, Christopher D., Priestley, Rachael A., Pyle, Meredith, Rayfield, Mark, Russell, Brandy J., Salzer, Johanna S., Sanchez, Angela J., Schuh, Amy J., Sealy, Tara K., Steinau, Martin, Stoddard, Robyn A., Taboy, Céline, Turnsek, Maryann, Wang, David, Zemtsova, Galina E., Zivcec, Marko, Spiropoulou, Christina F., Ströher, Ute, Towner, Jonathan S., Nichol, Stuart T., and Bird, Brian H.

Published
2015

44. Rotavirus genotypes in Belarus, 2008–2012

Author

Semeiko, Galina V., Yermalovich, Marina A., Poliakova, Nadezhda, Mijatovic-Rustempasic, Slavica, Kerin, Tara K., Wasley, Annemarie, Videbaek, Dovile, Gentsch, Jon R., Bowen, Michael D., and Samoilovich, Elena O.

Published
2014
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48. Rotavirus Vaccine Impact Within an Integrated Healthcare Delivery System in the United States

Author

Burke, Rachel M, primary, Tate, Jacqueline E, additional, Groom, Holly, additional, Parashar, Umesh D, additional, Mattison, Claire P, additional, Donald, Judy, additional, Salas, S Bianca, additional, Naleway, Allison L, additional, Lee, Mi H, additional, Dickerson, John F, additional, Biggs, Christianne, additional, Tsaknaridis, Laura, additional, Bowen, Michael D, additional, Schmidt, Mark, additional, and Hall, Aron J, additional

Published
2022
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49. Aetiology and incidence of diarrhoea requiring hospitalisation in children under 5 years of age in 28 low-income and middle-income countries: findings from the Global Pediatric Diarrhea Surveillance network

Author

Cohen, Adam L, primary, Platts-Mills, James A, additional, Nakamura, Tomoka, additional, Operario, Darwin J, additional, Antoni, Sébastien, additional, Mwenda, Jason M, additional, Weldegebriel, Goitom, additional, Rey-Benito, Gloria, additional, de Oliveira, Lucia H, additional, Ortiz, Claudia, additional, Daniels, Danni S, additional, Videbaek, Dovile, additional, Singh, Simarjit, additional, Njambe, Emmanuel, additional, Sharifuzzaman, Mohamed, additional, Grabovac, Varja, additional, Nyambat, Batmunkh, additional, Logronio, Josephine, additional, Armah, George, additional, Dennis, Francis E, additional, Seheri, Mapaseka L, additional, Magagula, Nokululeko, additional, Mphahlele, Jeffrey, additional, Fumian, Tulio M, additional, Maciel, Irene T A, additional, Gagliardi Leite, Jose Paulo, additional, Esona, Matthew D, additional, Bowen, Michael D, additional, Samoilovich, Elena, additional, Semeiko, Galina, additional, Abraham, Dilip, additional, Giri, Sidhartha, additional, Praharaj, Ira, additional, Kang, Gagandeep, additional, Thomas, Sarah, additional, Bines, Julie, additional, Liu, Na, additional, Kyu, Hmwe H, additional, Doxey, Matthew, additional, Rogawski McQuade, Elizabeth T, additional, McMurry, Timothy L, additional, Liu, Jie, additional, Houpt, Eric R, additional, Tate, Jacqueline E, additional, Parashar, Umesh D, additional, and Serhan, Fatima, additional

Published
2022
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50. Rotavirus Strain Trends in United States, 2009–2016: Results from the National Rotavirus Strain Surveillance System (NRSSS)

Author

Mijatovic-Rustempasic, Slavica, primary, Jaimes, Jose, additional, Perkins, Charity, additional, Ward, M. Leanne, additional, Esona, Mathew D., additional, Gautam, Rashi, additional, Lewis, Jamie, additional, Sturgeon, Michele, additional, Panjwani, Junaid, additional, Bloom, Gail A., additional, Miller, Steve, additional, Reisdorf, Erik, additional, Riley, Ann Marie, additional, Pence, Morgan A., additional, Dunn, James, additional, Selvarangan, Rangaraj, additional, Jerris, Robert C., additional, DeGroat, Dona, additional, Parashar, Umesh D., additional, Cortese, Margaret M., additional, and Bowen, Michael D., additional

Published
2022
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