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1. Impact of Landscape Fire Smoke Exposure on Patients With Asthma With or Without Laryngeal Hypersensitivity

Author

Vertigan, Anne E., Harvey, Erin S., Beyene, Tesfalidet, Van Buskirk, Joseph, Holliday, Elizabeth G., Bone, Sarah L., McDonald, Vanessa M., Horvat, Jay C., Murphy, Vanessa E., Jensen, Megan E., Morgan, Geoffrey G., Zosky, Graeme R., Peters, Matthew, Farah, Claude S., Jenkins, Christine R., Katelaris, Constance H., Harrington, John, Langton, David, Bardin, Philip, Katsoulotos, Gregory P., Upham, John W., Chien, Jimmy, Bowden, Jeffrey J., Rimmer, Janet, Bell, Rose, and Gibson, Peter G.

Published
2023
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2. Comorbidities Modify the Phenotype but Not the Treatment Effectiveness to Mepolizumab in Severe Eosinophilic Asthma

Author

Baraket, Melissa, Bardin, Philip, Bowden, Jeffrey J., Bowler, Simon, Chien, Jimmy, Chung, Li Ping, Grainge, Christopher, Harkness, Nicholas, Harrington, Zinta, Jenkins, Christine, Katsoulotos, Gregory P., McDonald, Vanessa M., Lee, Joy, Peters, Matthew, Reddel, Helen K., Reynolds, Paul N., Sivakumaran, Pathmanathan, Upham, John W., Wark, Peter A.B., Kritikos, Vicky, Harvey, Erin S., Stevens, Sean, Katelaris, Constance H., Langton, David, Rimmer, Janet, Farah, Claude S., Gillman, Andrew, Hew, Mark, Radhakrishna, Naghmeh, Thomas, Dennis, and Gibson, Peter G.

Published
2023
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3. Mepolizumab and Oral Corticosteroid Stewardship: Data from the Australian Mepolizumab Registry

Author

Thomas, Dennis, Harvey, Erin S., McDonald, Vanessa M., Stevens, Sean, Upham, John W., Katelaris, Constance H., Kritikos, Vicky, Gillman, Andrew, Harrington, John, Hew, Mark, Bardin, Philip, Peters, Matthew, Reynolds, Paul N., Langton, David, Baraket, Melissa, Bowden, Jeffrey J., Bowler, Simon, Chien, Jimmy, Chung, Li Ping, Farah, Claude S., Grainge, Christopher, Jenkins, Christine, Katsoulotos, Gregory P., Lee, Joy, Radhakrishna, Naghmeh, Reddel, Helen K., Rimmer, Janet, Sivakumaran, Pathmanathan, Wark, Peter A.B., and Gibson, Peter G.

Published
2021
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4. Biologics (mepolizumab and omalizumab) induced remission in severe asthma patients.

Author

Thomas, Dennis, McDonald, Vanessa M., Stevens, Sean, Harvey, Erin S., Baraket, Melissa, Bardin, Philip, Bowden, Jeffrey J., Bowler, Simon, Chien, Jimmy, Chung, Li Ping, Gillman, Andrew, Hew, Mark, Hodge, Sandra, James, Alan, Jenkins, Christine, Katelaris, Constance H., Katsoulotos, Gregory P., Langton, David, Lee, Joy, and Marks, Guy

Subjects
ASTHMATICS, OMALIZUMAB, DISEASE remission, BODY mass index, BIOLOGICALS, INTERSTITIAL lung diseases
Abstract

Background: Asthma remission has emerged as a potential treatment goal. This study evaluated the effectiveness of two biologics (mepolizumab/omalizumab) in achieving asthma remission. Methods: This observational study included 453 severe asthma patients (41% male; mean age ± SD 55.7 ± 14.7 years) from two real‐world drug registries: the Australian Mepolizumab Registry and the Australian Xolair Registry. The composite outcome clinical remission was defined as zero exacerbations and zero oral corticosteroids during the previous 6 months assessed at 12 months and 5‐item Asthma Control Questionnaire (ACQ‐5) ≤1 at 12 months. We also assessed clinical remission plus optimization (post‐bronchodilator FEV1 ≥80%) or stabilization (post‐bronchodilator FEV1 not greater than 5% decline from baseline) of lung function at 12 months. Sensitivity analyses explored various cut‐offs of ACQ‐5/FEV1 scores. The predictors of clinical remission were identified. Results: 29.3% (73/249) of AMR and 22.8% (37/162) of AXR cohort met the criteria for clinical remission. When lung function criteria were added, the remission rates were reduced to 25.2% and 19.1%, respectively. Sensitivity analyses identified that the remission rate ranged between 18.1% and 34.9% in the AMR cohort and 10.6% and 27.2% in the AXR cohort. Better lung function, lower body mass index, mild disease and absence of comorbidities such as obesity, depression and osteoporosis predicted the odds of achieving clinical remission. Conclusion: Biologic treatment with mepolizumab or omalizumab for severe asthma‐induced asthma remission in a subgroup of patients. Remission on treatment may be an achievable treatment target and future studies should consider remission as an outcome measure. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Comorbidities Modify the Phenotype but Not the Treatment Effectiveness to Mepolizumab in Severe Eosinophilic Asthma

Author

Kritikos, Vicky, primary, Harvey, Erin S., additional, Stevens, Sean, additional, Katelaris, Constance H., additional, Langton, David, additional, Rimmer, Janet, additional, Farah, Claude S., additional, Gillman, Andrew, additional, Hew, Mark, additional, Radhakrishna, Naghmeh, additional, Thomas, Dennis, additional, Gibson, Peter G., additional, Baraket, Melissa, additional, Bardin, Philip, additional, Bowden, Jeffrey J., additional, Bowler, Simon, additional, Chien, Jimmy, additional, Chung, Li Ping, additional, Grainge, Christopher, additional, Harkness, Nicholas, additional, Harrington, Zinta, additional, Jenkins, Christine, additional, Katsoulotos, Gregory P., additional, McDonald, Vanessa M., additional, Lee, Joy, additional, Peters, Matthew, additional, Reddel, Helen K., additional, Reynolds, Paul N., additional, Sivakumaran, Pathmanathan, additional, Upham, John W., additional, and Wark, Peter A.B., additional

Published
2022
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7. ‘Breathing Fire’: Impact of Prolonged Bushfire Smoke Exposure in People with Severe Asthma

Author

Beyene, Tesfalidet, primary, Harvey, Erin S., additional, Van Buskirk, Joseph, additional, McDonald, Vanessa M., additional, Jensen, Megan E., additional, Horvat, Jay C., additional, Morgan, Geoffrey G., additional, Zosky, Graeme R., additional, Jegasothy, Edward, additional, Hanigan, Ivan, additional, Murphy, Vanessa E., additional, Holliday, Elizabeth G., additional, Vertigan, Anne E., additional, Peters, Matthew, additional, Farah, Claude S., additional, Jenkins, Christine R., additional, Katelaris, Constance H., additional, Harrington, John, additional, Langton, David, additional, Bardin, Philip, additional, Katsoulotos, Gregory P., additional, Upham, John W., additional, Chien, Jimmy, additional, Bowden, Jeffrey J., additional, Rimmer, Janet, additional, Bell, Rose, additional, and Gibson, Peter G., additional

Published
2022
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12. Mepolizumab effectiveness and identification of super-responders in severe asthma

Author

Harvey, Erin S., primary, Langton, David, additional, Katelaris, Constance, additional, Stevens, Sean, additional, Farah, Claude S., additional, Gillman, Andrew, additional, Harrington, John, additional, Hew, Mark, additional, Kritikos, Vicky, additional, Radhakrishna, Naghmeh, additional, Bardin, Philip, additional, Peters, Matthew, additional, Reynolds, Paul N., additional, Upham, John W., additional, Baraket, Melissa, additional, Bowler, Simon, additional, Bowden, Jeffrey, additional, Chien, Jimmy, additional, Chung, Li Ping, additional, Grainge, Christopher, additional, Jenkins, Christine, additional, Katsoulotos, Gregory P., additional, Lee, Joy, additional, McDonald, Vanessa M., additional, Reddel, Helen K., additional, Rimmer, Janet, additional, Wark, Peter A.B., additional, and Gibson, Peter G., additional

Published
2020
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14. Shedding of L-selectin and PECAM-1 and upregulation of Mac-1 and ICAM-1 on neutrophils in RSV bronhiolitis

Author

Wang, Shan-Ze, Smith, Peter K., Lovejoy, Melanie, Bowden, Jeffrey J., Alpers, John H., and Forsyth, Kevin D.

Subjects
Blood platelets -- Research, Bronchiolitis -- Research, Cell adhesion molecules -- Research, Neutrophils -- Research, Respiratory syncytial virus -- Research, Virus diseases -- Research, Biological sciences
Abstract

Research was conducted to examine the expression of the adhesion molecules L-selectin (CD62L), leukocyte function-associated antigen-1 and Mac-1 on neutrophils in respiratory syncytial virus (RSV) bronchiolitis. Another objective was to determine whether adhesion molecules such as platelet endothelial cell adhesion molecule (PECAM)-1 and intercellular adhesion molecule may be changed and involved in RSV disease. Results indicate that both L-selectin and PECAM-1 on neutrophils from nasopharyngeal aspirates of RSV-positive infants are downregulated compared with peripheral blood cells.

Published
1998

15. Upregulation of substance P receptors in angiogenesis associated with chronic airway inflammation in rats

Author

Baluk, Peter, Bowden, Jeffrey J., Lefevre, Peter M., and McDonald, Donald M.

Subjects
Substance P -- Physiological aspects, Neovascularization -- Development and progression, Airway (Medicine) -- Research, Rats -- Physiological aspects, Biological sciences
Abstract

The expression of neurokinin-1 (NK1) receptors in the endothelial cells of angiogenic blood vessels which are hypersensitive to substance P was investigated. Pathogen-free male Fischer 344 rats were used as experimental models to assess whether there is an increase in the amount of substance P-containing nerves near the leaky blood vessels. Results showed an upregulation of NK1 receptors on endothelium as reflected in the increase in number of immunoreactive endosomes in angiogenic capillaries.

Published
1997

16. Sensory denervation by neonatal capsaicin treatment exacerbates Mycoplasma pulmonis infection in rat airways

Author

Bowden, Jeffrey J., Baluk, Peter, Lefevre, Peter M., Schoeb, Trenton R., Lindsey, J. Russell, and McDonald, Donald M.

Subjects
Mycoplasmatales -- Physiological aspects, Capsaicin -- Physiological aspects, Inflammation -- Physiological aspects, Nervous system -- Physiological aspects, Biological sciences
Abstract

The effect of sensory denervation by capsaicin pretreatment at birth on immunologic response was investigated by measuring the number of Mycoplasma pulmonis organisms in the airway of rats. Capsaicin pretreatment increased the severity of the infection, as indicated by the increased thickness of the tracheal mucosa and the increase in substance P-induced plasma leakage. There was also a significant reduction in the number of SP-immunoreactive nerve fibers after capsaicin pretreatment and during infection. This was attributed to the increased destruction of sensory nerves during inflammation.

Published
1996

17. Substance P (NK1) receptor immunoreactivity on endothelial cells of the rat tracheal mucosa

Author

Bowden, Jeffrey J., Baluk, Peter, Lefevre, Peter M., Vigna, Steven R., and McDonald, Donald M.

Subjects
Tachykinins -- Physiological aspects, Substance P -- Physiological aspects, Trachea -- Physiological aspects, Neural stimulation -- Physiological aspects, Biological sciences
Abstract

The relationship between substance P release and plasma leakage was investigated by examining the localization of neurokinin-1 receptors (NK1) in the rat tracheal mucosa after vagal stimulation. NK1 receptor-immunoreactive endosomes were found in the endothelial cells of venules and capillaries but not in the arterioles. Vagal stimulation increased the number of endosomes in the capillaries. The increase corresponded to the amount of plasma leakage. These effects were blocked by the NK1 receptor antagonist SR-140333.

Published
1996

18. Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation

Author

Bowden, Jeffrey J., Garland, Adella M., Baluk, Peter, Faber, Peter, Grady, Eileen F., Vigna, Steven R., Bunnett, Nigel W., and McDonald, Donald M.

Subjects
Substance P -- Physiological aspects, Tachykinins -- Research, Endothelium -- Research, Science and technology
Abstract

Use of an antibody against neurokinin type 1 (Nk1) receptor on the endothelial cell surface reveals that Substance P (SP) induces NK1 receptor internalization into the endosomes of endothelial cells in postcapillary venules to restrict plasma leakage at inflammation sites. The number of immunoreactive endosomes reaches 107 per cell, compared to 15 per cell in SP lacking endothelial cells, but subsequently reaches the normal value in 120 minutes. NK1 receptor transfections in cultured endothelial cells and their exposure to rhodamine-SP indicate the co-internalization of SP and the receptor antibody.

Published
1994

19. Neurogenic Inflammation

Author

McDonald, Donald M., primary, Bowden, Jeffrey J., additional, Baluk, Peter, additional, and Bunnett, Nigel W., additional

Published
1996
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21. Survival and late toxicities following concurrent chemo-radiotherapy for locally advanced stage III non-small cell lung cancer: findings of a 10-year Australian single centre experience with long term clinical follow up

Author

Abbas, M. Nazim, primary, Ayoola, Adeola, additional, Padman, Sunita, additional, Kumar, Rajiv, additional, Leung, John, additional, Ullah, Shahid, additional, Koczwara, Bogda, additional, Sukumaran, Shawgi, additional, Kichenadasse, Ganessan, additional, Roy, Amitesh, additional, Richards, Alison M., additional, Bowden, Jeffrey J., additional, and Karapetis, Christos S., additional

Published
2019
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22. Employee assistance program compliance: impact of contrasting insurance coverage

Author

Fiedler, Nancy, Bowden, Jeffrey, Kelly-McNeil, Kathleen, Steinberg, Michael, and Gochfeld, Michael

Subjects
Employee assistance programs -- Evaluation, Occupational health services -- Usage, Business, Health care industry
Abstract

Employee Assistance Programs (EAP) have been established by employers to provide their employees with professional assistance in the solution of personal problems. The EAP either provides assistance itself, or refers the employee to agencies and professionals more suited to resolving a particular problem. These programs are usually directed at alcohol and substance abuse issues, or family, financial and personal matters. The success of these programs depends on the employees' compliance with the professional recommendations. This study was conducted to compare the compliance rate between two comparable employee organizations, with different co-payment rates for mental health services. The organizations both operated toll roads in the same state, and both organizations (A and B) contracted with the same medical school for the same services - the Division of Occupational Health in the Department of Environmental and Community Medicine at the Robert Wood Johnson Medical School. Compliance was defined as the number of sessions attended by a referred (or self-referred) employee at an outpatient mental health service. Company B reimbursed up to $1,000 per year, while company A reimbursed up to $2,000 per year. Forty-two employees of company A and 61 from company B were enrolled in the study. Demographic data were collected from each employee; most of the subjects were white, high-school educated, and married. Employees from company A were more compliant than the employees of the other company. Company A offered a higher rate of reimbursement, and their employees initiated treatment more frequently and were in treatment for a longer period of time. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

23. Treatable traits can be identified in a severe asthma registry and predict future exacerbations

Author

McDonald, Vanessa M., primary, Hiles, Sarah A., additional, Godbout, Krystelle, additional, Harvey, Erin S., additional, Marks, Guy B., additional, Hew, Mark, additional, Peters, Matthew, additional, Bardin, Philip G., additional, Reynolds, Paul N., additional, Upham, John W., additional, Baraket, Melissa, additional, Bhikoo, Zaheerodin, additional, Bowden, Jeffrey, additional, Brockway, Ben, additional, Chung, Li Ping, additional, Cochrane, Belinda, additional, Foxley, Gloria, additional, Garrett, Jeffrey, additional, Jayaram, Lata, additional, Jenkins, Christine, additional, Katelaris, Constance, additional, Katsoulotos, Gregory, additional, Koh, Mariko S., additional, Kritikos, Vicky, additional, Lambert, Marina, additional, Langton, David, additional, Lara Rivero, Alexis, additional, Middleton, Peter G., additional, Nanguzgambo, Aldoph, additional, Radhakrishna, Naghmeh, additional, Reddel, Helen, additional, Rimmer, Janet, additional, Southcott, Anne Marie, additional, Sutherland, Michael, additional, Thien, Francis, additional, Wark, Peter A.B., additional, Yang, Ian A., additional, Yap, Elaine, additional, and Gibson, Peter G., additional

Published
2018
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24. Identification of treatable traits in a severe asthma registry: prevalence and exacerbation predictors

Author

McDonald, Vanessa M., primary, Hiles, Sarah A., additional, Godbout, Krystelle, additional, Harvey, Erin S., additional, Marks, Guy B., additional, Hew, Mark, additional, Peters, Matthew, additional, Bardin, Philip, additional, Reynolds, Paul N., additional, Upham, John W., additional, Baraket, Melissa, additional, Bhikoo, Zaheerodin, additional, Bowden, Jeffrey, additional, Brockway, Ben, additional, Chung, Li Ping, additional, Cochrane, Belinda, additional, Foxley, Gloria, additional, Garrett, Jeffrey, additional, Jayaram, Lata, additional, Jenkins, Christine, additional, Katelaris, Constance, additional, Katsoulotos, Gregory, additional, Koh, Mariko S., additional, Kritikos, Vicky, additional, Lambert, Marina, additional, Langton, David, additional, Lara Rivero, Alexis, additional, Middleton, Peter, additional, Nanguzgambo, Aldoph, additional, Radhakrishna, Naghmeh, additional, Reddel, Helen, additional, Rimmer, Janet, additional, Southcott, Anne Marie, additional, Sutherland, Michael, additional, Thien, Francis, additional, Wark, Peter, additional, Yang, Ian A., additional, Yap, Elaine, additional, and Gibson, Peter G., additional

Published
2018
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26. Treatable traits can be identified in a severe asthma registry and predict future exacerbations.

Author

McDonald, Vanessa M., Hiles, Sarah A., Harvey, Erin S., Wark, Peter A.B., Gibson, Peter G., Upham, John W., Baraket, Melissa, Bhikoo, Zaheerodin, Bowden, Jeffrey, Brockway, Ben, Chung, Li Ping, Cochrane, Belinda, Katelaris, Constance, Godbout, Krystelle, Garrett, Jeffrey, Yap, Elaine, Jayaram, Lata, Southcott, Anne Marie, Katsoulotos, Gregory, and Lara Rivero, Alexis

Subjects
INHALERS, VOCAL cord dysfunction, ASTHMA
Abstract

Background and objective: A new taxonomic and management approach, termed treatable traits, has been proposed for airway diseases including severe asthma. This study examined whether treatable traits could be identified using registry data and whether particular treatable traits were associated with future exacerbation risk. Methods: The Australasian Severe Asthma Web‐Based Database (SAWD) enrolled 434 participants with severe asthma and a comparison group of 102 participants with non‐severe asthma. Published treatable traits were mapped to registry data fields and their prevalence was described. Participants were characterized at baseline and every 6 months for 24 months. Results: In SAWD, 24 treatable traits were identified in three domains: pulmonary, extrapulmonary and behavioural/risk factors. Patients with severe asthma expressed more pulmonary and extrapulmonary treatable traits than non‐severe asthma. Allergic sensitization, upper‐airway disease, airflow limitation, eosinophilic inflammation and frequent exacerbations were common in severe asthma. Ten traits predicted exacerbation risk; among the strongest were being prone to exacerbations, depression, inhaler device polypharmacy, vocal cord dysfunction and obstructive sleep apnoea. Conclusion: Treatable traits can be assessed using a severe asthma registry. In severe asthma, patients express more treatable traits than non‐severe asthma. Traits may be associated with future asthma exacerbation risk demonstrating the clinical utility of assessing treatable traits. We assessed the prevalence of treatable traits in severe asthma compared with non‐severe asthma, and assessed the relationship between treatable traits and future exacerbation risk. We demonstrate the usefulness of the treatable traits approach in severe asthma and which specific treatable traits are predictive of future asthma attacks. See relatedEditorial [ABSTRACT FROM AUTHOR]

Published
2019
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27. Warfarin resistance associated with genetic polymorphism of VKORC1: linking clinical response to molecular mechanism using computational modeling.

Author

Lewis, Benjamin C, Nair, Pramod C, Heran, Subash S, Somogyi, Andrew A, Bowden, Jeffrey J, Doogue, Matthew P, Miners, John O, Lewis, Benjamin C, Nair, Pramod C, Heran, Subash S, Somogyi, Andrew A, Bowden, Jeffrey J, Doogue, Matthew P, and Miners, John O

Abstract

The variable response to warfarin treatment often has a genetic basis. A protein homology model of human vitamin K epoxide reductase, subunit 1 (VKORC1), was generated to elucidate the mechanism of warfarin resistance observed in a patient with the Val66Met mutation. The VKORC1 homology model comprises four transmembrane (TM) helical domains and a half helical lid domain. Cys132 and Cys135, located in the N-terminal end of TM-4, are linked through a disulfide bond. Two distinct binding sites for warfarin were identified. Site-1, which binds vitamin K epoxide (KO) in a catalytically favorable orientation, shows higher affinity for S-warfarin compared with R-warfarin. Site-2, positioned in the domain occupied by the hydrophobic tail of KO, binds both warfarin enantiomers with similar affinity. Displacement of Arg37 occurs in the Val66Met mutant, blocking access of warfarin (but not KO) to Site-1, consistent with clinical observation of warfarin resistance.

Published
2016

35. Comorbidities Modify the Phenotype but Not the Treatment Effectiveness to Mepolizumab in Severe Eosinophilic Asthma

Author

Kritikos, Vicky, Harvey, Erin S., Stevens, Sean, Katelaris, Constance H., Langton, David, Rimmer, Janet, Farah, Claude S., Gillman, Andrew, Hew, Mark, Radhakrishna, Naghmeh, Thomas, Dennis, Gibson, Peter G., Baraket, Melissa, Bardin, Philip, Bowden, Jeffrey J., Bowler, Simon, Chien, Jimmy, Chung, Li Ping, Grainge, Christopher, Harkness, Nicholas, Harrington, Zinta, Jenkins, Christine, Katsoulotos, Gregory P., McDonald, Vanessa M., Lee, Joy, Peters, Matthew, Reddel, Helen K., Reynolds, Paul N., Sivakumaran, Pathmanathan, Upham, John W., and Wark, Peter A.B.

Abstract

Comorbidities in severe asthma are common and contribute to disease burden. The severe asthma phenotype and treatment response can be impacted by comorbid conditions. Real-world data on the use of mepolizumab in severe eosinophilic asthma (SEA) in the presence of comorbidities are needed to inform clinical practice.

Published
2023
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40. Antiandrogenic Effects of Topically Applied Spironolactone on the Hamster Flank Organ

Author

Weissmann, Arthur, Bowden, Jeffrey, Frank, Beryn L., Horwitz, Stephen N., and Frost, Phillip

Abstract

• The effects of topically applied spironolactone on the sebaceous glands of flank organs in adult male golden hamsters were investigated. Daily treatment with spironolactone (0.3 mg and 3 mg) on one side only significantly reduced the size of the treated flank organs, while the contralateral flank organs remained unchanged. Lower doses of spironolactone and the vehicle had no effect. Cyproterone acetate therapy resulted in the bilateral reduction of flank organ sizes. In vivo measurement of the palpable bulk of the flank organs correlated with flank organ volumes as determined by computer-assisted planimetry of serial histologic sections. Dry weights of seminal vesicles in animals treated with spironolactone did not differ significantly from those of the control group, while topically applied cyproterone acetate significantly reduced seminal vesicle weight. Topically administered spironolactone appears to have only local antiandrogenic effects, as indicated by the lack of changes in the untreated contralateral flank organs and in the weights of seminal vesicles.(Arch Dermatol 1985;121:57-62)

Published
1985
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