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1. Response and remission rates during 24 weeks of mood-stabilizing treatment for bipolar depression depending on early non-response

Author

Köhler-Forsberg, Ole, Sloth, Kirstine H., Sylvia, Louisa G., Thase, Michael, Calabrese, Joseph R., Tohen, Mauricio, Bowden, Charles L., McInnis, Melvin, Kocsis, James H., Friedman, Edward S., Ketter, Terence A., McElroy, Susan L., Shelton, Richard C, Iosifescu, Dan V, Ostacher, Michael J., and Nierenberg, Andrew A.

Published
2021
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3. Familial severe psychiatric history in bipolar disorder and correlation with disease severity and treatment response

Author

Köhler-Forsberg, Ole, Sylvia, Louisa G., Ruberto, Valerie L., Kuperberg, Maya, Shannon, Alec P., Fung, Vicki, Overhage, Lindsay, Calabrese, Joseph R., Thase, Michael, Bowden, Charles L., Shelton, Richard C., McInnis, Melvin, Deckersbach, Thilo, Tohen, Mauricio, Kocsis, James H., Ketter, Terence A., Friedman, Edward S., Iosifescu, Dan V., McElroy, Susan, Ostacher, Michael J, and Nierenberg, Andrew A.

Published
2020
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5. The impact of binge eating behavior on lithium- and quetiapine-associated changes in body weight, body mass index, and waist circumference during 6 months of treatment: Findings from the bipolar CHOICE study

Author

Yaramala, Satyanarayana R., McElroy, Susan L., Geske, Jennifer, Winham, Stacey, Gao, Keming, Reilly-Harrington, Noreen A., Ketter, Terence A., Deckersbach, Thilo, Kinrys, Gustavo, Kamali, Masoud, Sylvia, Louisa G., McInnis, Melvin G., Friedman, Edward S., Thase, Machael E., Kocsis, James H., Tohen, Mauricio, Calabrese, Joseph R., Bowden, Charles L., Shelton, Richard C., Nierenberg, Andrew A., and Bobo, William V.

Published
2020
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7. Bipolar depression and suicidal ideation: Moderators and mediators of a complex relationship

Author

Kamali, Masoud, Reilly-Harrington, Noreen A., Chang, Weilynn C., McInnis, Melvin, McElroy, Susan L., Ketter, Terence A., Shelton, Richard C., Deckersbach, Thilo, Tohen, Mauricio, Kocsis, James H., Calabrese, Joseph R., Gao, Keming, Thase, Michael E., Bowden, Charles L., Kinrys, Gustavo, Bobo, William V., Brody, Benjamin D., Sylvia, Louisa G., Rabideau, Dustin J., and Nierenberg, Andrew A.

Published
2019
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12. Sleep disturbance may impact treatment outcome in bipolar disorder: A preliminary investigation in the context of a large comparative effectiveness trial

Author

Sylvia, Louisa G., Chang, Weilynn C., Kamali, Masoud, Tohen, Mauricio, Kinrys, Gustavo, Deckersbach, Thilo, Calabrese, Joseph R., Thase, Michael E., Reilly-Harrington, Noreen, Bobo, William V., Kocsis, James H., McInnis, Melvin G., Bowden, Charles L., Ketter, Terence A., Friedman, Edward S., Shelton, Richard C., McElroy, Susan L., Gao, Keming, Rabideau, Dustin J., and Nierenberg, Andrew A.

Published
2018
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14. Trajectories of suicidal ideation over 6 months among 482 outpatients with bipolar disorder

Author

Köhler-Forsberg, Ole, Madsen, Trine, Behrendt-Møller, Ida, Sylvia, Louisa, Bowden, Charles L., Gao, Keming, Bobo, William V., Trivedi, Madhukar H., Calabrese, Joseph R., Thase, Michael, Shelton, Richard C., McInnis, Melvin, Tohen, Mauricio, Ketter, Terence A., Friedman, Edward S., Deckersbach, Thilo, McElroy, Susan L., Reilly-Harrington, Noreen A., and Nierenberg, Andrew A.

Published
2017
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17. Bipolar mixed features – Results from the comparative effectiveness for bipolar disorder (Bipolar CHOICE) study

Author

Tohen, Mauricio, Gold, Alexandra K., Sylvia, Louisa G., Montana, Rebecca E., McElroy, Susan L., Thase, Michael E., Rabideau, Dustin J., Nierenberg, Andrew A., Reilly-Harrington, Noreen A., Friedman, Edward S., Shelton, Richard C., Bowden, Charles L., Singh, Vivek, Deckersbach, Thilo, Ketter, Terence A., Calabrese, Joseph R., Bobo, William V., and McInnis, Melvin G.

Published
2017
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18. Clinical correlates of acute bipolar depressive episode with psychosis

Author

Caldieraro, Marco Antonio, Sylvia, Louisa G., Dufour, Steven, Walsh, Samantha, Janos, Jessica, Rabideau, Dustin J., Kamali, Masoud, McInnis, Melvin G., Bobo, William V., Friedman, Edward S., Gao, Keming, Tohen, Mauricio, Reilly-Harrington, Noreen A., Ketter, Terence A., Calabrese, Joseph R., McElroy, Susan L., Thase, Michael E., Shelton, Richard C., Bowden, Charles L., Kocsis, James H., Deckersbach, Thilo, and Nierenberg, Andrew A.

Published
2017
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19. KIOS: A smartphone app for self‐monitoring for patients with bipolar disorder.

Author

Pahwa, Mehak, McElroy, Susan L., Priesmeyer, Richard, Siegel, Gregg, Siegel, Phyllis, Nuss, Sharon, Bowden, Charles L., and El‐Mallakh, Rif S.

Subjects
PATIENT self-monitoring, MOBILE apps, BIPOLAR disorder, PATIENT satisfaction, SYSTEMS software
Abstract

Objectives: This study examined the use of a self‐monitoring/self‐management smartphone application (app) for patients with bipolar disorder. The app was specifically designed with patient‐centered computational software system based on concepts from nonlinear systems (chaos) theory. Methods: This was a randomized, active comparator study of use of the KIOS app compared to an existing free app that has high utilization rates known as eMoods, over 52 weeks, and performed in three academic centers. Patients were evaluated monthly utilizing the Bipolar Inventory of Symptoms Schedule (BISS). The primary outcome measure was the persistence of using the app over the year of the study. Results: Patients assigned to KIOS persisted in the study longer than those assigned to eMoods; 57 patients (87.70%) in the KIOS group versus 42 (73.69%) in the eMoods group completed the study (p = 0.03). By 52 weeks, significantly more of KIOS group (84.4%) versus eMoods group (54%) entered data into their programs (χ2 = 14.2, df = 1, p = 0.0002). Patient satisfaction for KIOS was greater (F = 5.21, df = 1, 108, p = 0.025) with a standardized effect size (Cohen's d) of 0.41. There was no difference in clinical outcome at the end of the study between the two groups. Conclusions: This is the first randomized comparison study comparing two apps for the self‐monitoring/self‐management of bipolar disorder. The study revealed greater patient satisfaction and greater adherence to a patient‐centered software program (KIOS) than a monitoring program that does not provide feedback (eMoods). [ABSTRACT FROM AUTHOR]

Published
2024
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20. Original Article A Randomized, Placebo-Controlled 12-Month Trial of Divalproex and Lithium in Treatment of Outpatients With Bipolar I Disorder

Author

Bowden, Charles L., primary, Calabrese, Joseph R., additional, McElroy, Susan L., additional, Gyulai, Laszlo, additional, Wassef, Adel, additional, Petty, Frederick, additional, Pope, Harrison G., additional, Chou, James C.-Y., additional, Keck, Paul E., additional, Rhodes, Linda J., additional, Swann, Alan C., additional, Hirschfeld, Robert M. A., additional, and Wozniak, Patricia J., additional

Published
2019
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22. Tracking medication changes to assess outcomes in comparative effectiveness research: A bipolar CHOICE study

Author

Reilly-Harrington, Noreen A., Sylvia, Louisa G., Rabideau, Dustin J., Gold, Alexandra K., Deckersbach, Thilo, Bowden, Charles L., Bobo, William V., Singh, Vivek, Calabrese, Joseph R., Shelton, Richard C., Friedman, Edward S., Thase, Michael E., Kamali, Masoud, Tohen, Mauricio, McInnis, Melvin G., McElroy, Susan L., Ketter, Terence A., Kocsis, James H., Kinrys, Gustavo, and Nierenberg, Andrew A.

Published
2016
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23. A tool to predict suicidal ideation and behavior in bipolar disorder: The Concise Health Risk Tracking Self-Report

Author

Reilly-Harrington, Noreen A., Shelton, Richard C., Kamali, Masoud, Rabideau, Dustin J., Shesler, Leah W., Trivedi, Madhukar H., McElroy, Susan L., Sylvia, Louisa G., Bowden, Charles L., Ketter, Terence A., Calabrese, Joseph R., Thase, Michael E., Bobo, William V., Deckersbach, Thilo, Tohen, Mauricio, McInnis, Melvin G., Kocsis, James H., Gold, Alexandra K., Singh, Vivek, Finkelstein, Daniel M., Kinrys, Gustavo, and Nierenberg, Andrew A.

Published
2016
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24. A clinical measure of suicidal ideation, suicidal behavior, and associated symptoms in bipolar disorder: Psychometric properties of the Concise Health Risk Tracking Self-Report (CHRT-SR)

Author

Ostacher, Michael J., Nierenberg, Andrew A., Rabideau, Dustin, Reilly-Harrington, Noreen A., Sylvia, Louisa G., Gold, Alexandra K., Shesler, Leah W., Ketter, Terence A., Bowden, Charles L., Calabrese, Joseph R., Friedman, Edward S., Iosifescu, Dan V., Thase, Michael E., Leon, Andrew C., and Trivedi, Madhukar H.

Published
2015
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26. The Medication Recommendation Tracking Form: A novel tool for tracking changes in prescribed medication, clinical decision making, and use in comparative effectiveness research

Author

Reilly-Harrington, Noreen A., Sylvia, Louisa G., Leon, Andrew C., Shesler, Leah W., Ketter, Terence A., Bowden, Charles L., Calabrese, Joseph R., Friedman, Edward S., Ostacher, Michael J., Iosifescu, Dan V., Rabideau, Dustin J., Thase, Michael E., and Nierenberg, Andrew A.

Published
2013
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27. Association of exercise with quality of life and mood symptoms in a comparative effectiveness study of bipolar disorder

Author

Sylvia, Louisa G., Friedman, Edward S., Kocsis, James H., Bernstein, Emily E., Brody, Benjamin D., Kinrys, Gustavo, Kemp, David E., Shelton, Richard C., McElroy, Susan L., Bobo, William V., Kamali, Masoud, McInnis, Melvin G., Tohen, Mauricio, Bowden, Charles L., Ketter, Terence A., Deckersbach, Thilo, Calabrese, Joseph R., Thase, Michael E., Reilly-Harrington, Noreen A., Singh, Vivek, Rabideau, Dustin J., and Nierenberg, Andrew A.

Published
2013
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32. Childhood trauma and treatment outcomes during mood‐stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder

Author

Wrobel, Anna L., primary, Köhler‐Forsberg, Ole, additional, Sylvia, Louisa G., additional, Russell, Samantha E., additional, Dean, Olivia M., additional, Cotton, Sue M., additional, Thase, Michael, additional, Calabrese, Joseph R., additional, Deckersbach, Thilo, additional, Tohen, Mauricio, additional, Bowden, Charles L., additional, McInnis, Melvin G., additional, Kocsis, James H., additional, Friedman, Edward S., additional, Ketter, Terence A., additional, Shelton, Richard C., additional, Ostacher, Michael J., additional, Iosifescu, Dan V., additional, Berk, Michael, additional, Turner, Alyna, additional, and Nierenberg, Andrew A., additional

Published
2022
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33. Cardiometabolic risk markers during mood-stabilizing treatment: Correlation with drug-specific effects, depressive symptoms and treatment response

Author

Kuperberg, Maya, primary, Köhler-Forsberg, Ole, additional, Shannon, Alec P., additional, George, Nevita, additional, Greenebaum, Sophie, additional, Bowden, Charles L., additional, Calabrese, Joseph R., additional, Thase, Michael, additional, Shelton, Richard C., additional, McInnis, Melvin, additional, Deckersbach, Thilo, additional, Tohen, Mauricio, additional, Kocsis, James H., additional, Ketter, Terence A., additional, Friedman, Edward S., additional, Iosifescu, Dan V., additional, Ostacher, Michael J, additional, Sylvia, Louisa G., additional, McElroy, Susan L., additional, and Nierenberg, Andrew A., additional

Published
2022
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34. sj-docx-1-anp-10.1177_00048674221077619 ��� Supplemental material for Lithium plus antipsychotics or anticonvulsants for bipolar disorder: Comparing clinical response and metabolic changes

Author

K��hler-Forsberg, Ole, Sylvia, Louisa G, Thase, Michael, Calabrese, Joseph R, Tohen, Mauricio, Bowden, Charles L, McInnis, Melvin, Iosifescu, Dan V, Kocsis, James H, Friedman, Edward S, Ketter, Terence A, McElroy, Susan L, Shelton, Richard C, Fung, Vicki, Ostacher, Michael J, and Nierenberg, Andrew A

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, sj-docx-1-anp-10.1177_00048674221077619 for Lithium plus antipsychotics or anticonvulsants for bipolar disorder: Comparing clinical response and metabolic changes by Ole K��hler-Forsberg, Louisa G Sylvia, Michael Thase, Joseph R Calabrese, Mauricio Tohen, Charles L Bowden, Melvin McInnis, Dan V Iosifescu, James H Kocsis, Edward S Friedman, Terence A Ketter, Susan L McElroy, Richard C Shelton, Vicki Fung, Michael J Ostacher and Andrew A Nierenberg in Australian & New Zealand Journal of Psychiatry

Published
2022
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35. sj-pptx-1-anp-10.1177_00048674221077619 ��� Supplemental material for Lithium plus antipsychotics or anticonvulsants for bipolar disorder: Comparing clinical response and metabolic changes

Author

K��hler-Forsberg, Ole, Sylvia, Louisa G, Thase, Michael, Calabrese, Joseph R, Tohen, Mauricio, Bowden, Charles L, McInnis, Melvin, Iosifescu, Dan V, Kocsis, James H, Friedman, Edward S, Ketter, Terence A, McElroy, Susan L, Shelton, Richard C, Fung, Vicki, Ostacher, Michael J, and Nierenberg, Andrew A

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, sj-pptx-1-anp-10.1177_00048674221077619 for Lithium plus antipsychotics or anticonvulsants for bipolar disorder: Comparing clinical response and metabolic changes by Ole K��hler-Forsberg, Louisa G Sylvia, Michael Thase, Joseph R Calabrese, Mauricio Tohen, Charles L Bowden, Melvin McInnis, Dan V Iosifescu, James H Kocsis, Edward S Friedman, Terence A Ketter, Susan L McElroy, Richard C Shelton, Vicki Fung, Michael J Ostacher and Andrew A Nierenberg in Australian & New Zealand Journal of Psychiatry

Published
2022
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36. sj-pptx-2-anp-10.1177_00048674221077619 ��� Supplemental material for Lithium plus antipsychotics or anticonvulsants for bipolar disorder: Comparing clinical response and metabolic changes

Author

K��hler-Forsberg, Ole, Sylvia, Louisa G, Thase, Michael, Calabrese, Joseph R, Tohen, Mauricio, Bowden, Charles L, McInnis, Melvin, Iosifescu, Dan V, Kocsis, James H, Friedman, Edward S, Ketter, Terence A, McElroy, Susan L, Shelton, Richard C, Fung, Vicki, Ostacher, Michael J, and Nierenberg, Andrew A

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, sj-pptx-2-anp-10.1177_00048674221077619 for Lithium plus antipsychotics or anticonvulsants for bipolar disorder: Comparing clinical response and metabolic changes by Ole K��hler-Forsberg, Louisa G Sylvia, Michael Thase, Joseph R Calabrese, Mauricio Tohen, Charles L Bowden, Melvin McInnis, Dan V Iosifescu, James H Kocsis, Edward S Friedman, Terence A Ketter, Susan L McElroy, Richard C Shelton, Vicki Fung, Michael J Ostacher and Andrew A Nierenberg in Australian & New Zealand Journal of Psychiatry

Published
2022
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37. Lithium plus antipsychotics or anticonvulsants for bipolar disorder: Comparing clinical response and metabolic changes

Author

Köhler-Forsberg, Ole, primary, Sylvia, Louisa G, additional, Thase, Michael, additional, Calabrese, Joseph R, additional, Tohen, Mauricio, additional, Bowden, Charles L, additional, McInnis, Melvin, additional, Iosifescu, Dan V, additional, Kocsis, James H, additional, Friedman, Edward S, additional, Ketter, Terence A, additional, McElroy, Susan L, additional, Shelton, Richard C, additional, Fung, Vicki, additional, Ostacher, Michael J, additional, and Nierenberg, Andrew A, additional

Published
2022
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38. Lithium plus antipsychotics or anticonvulsants for bipolar disorder: Comparing clinical response and metabolic changes.

Author

Köhler-Forsberg, Ole, Sylvia, Louisa G, Thase, Michael, Calabrese, Joseph R, Tohen, Mauricio, Bowden, Charles L, McInnis, Melvin, Iosifescu, Dan V, Kocsis, James H, Friedman, Edward S, Ketter, Terence A, McElroy, Susan L, Shelton, Richard C, Fung, Vicki, Ostacher, Michael J, and Nierenberg, Andrew A

Subjects
THERAPEUTIC use of lithium, METABOLIC syndrome risk factors, METABOLIC syndrome diagnosis, ANTICONVULSANTS, DRUG efficacy, BIOMARKERS, LAMOTRIGINE, TRIGLYCERIDES, COMBINATION drug therapy, ANALYSIS of variance, ARIPIPRAZOLE, QUETIAPINE, REGRESSION analysis, BLOOD sugar, COMPARATIVE studies, DESCRIPTIVE statistics, ANTIPSYCHOTIC agents, BIPOLAR disorder, LITHIUM, SECONDARY analysis, VALPROIC acid, EVALUATION
Abstract

Objective: Patients with bipolar disorder treated with lithium often require additional antipsychotics or anticonvulsants. However, the comparative effectiveness and safety of these agents as add-on to lithium has not been studied. Methods: This secondary analysis combined two similar 24-week trials on outpatients with bipolar disorder randomized to lithium (target serum level 0.4–0.6 mEq/L). Guideline-based adjunctive antipsychotics (Li+AP) and anticonvulsants (Li+AC) could be used if clinically indicated and was assessed at every study visit. Response was measured on the Clinical Global Impression scale and we performed adjusted mixed effects linear regression analyses. Analysis of variance tests compared metabolic measures including a binary diagnosis of metabolic syndrome before and after 24 weeks of treatment. Results: Among 379 outpatients (57% female, mean age 38 years, mean Clinical Global Impression 4.4), users of Li+AP (N = 50, primarily quetiapine and aripiprazole) improved to a similar degree (mean Clinical Global Impression improvement = 1.6, standard deviation = 1.5) as those using lithium-only (i.e. without adjunctive antipsychotics or anticonvulsants, N = 149, mean Clinical Global Impression improvement = 1.7, standard deviation = 1.4) (p = 0.59). Users of Li+AC (N = 107, primarily lamotrigine and valproate, mean Clinical Global Impression improvement = 1.2, standard deviation = 1.3) and users of Li+AP+AC (N = 73, mean Clinical Global Impression improvement = 1.1, standard deviation = 1.3) showed worse response compared to lithium-only users (all p < 0.01). When comparing Li+AP to Li+AC, users of Li+AP improved slightly better on general (p = 0.05) and manic symptoms (p = 0.01), but showed a worse development of glucose, triglycerides, and metabolic syndrome. Conclusion: Despite treatment-by-indication confounding, these findings are relevant for real-world treatment settings and emphasize the need for randomized trials on this clinically important topic. [ABSTRACT FROM AUTHOR]

Published
2023
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39. List of Contributors

Author

Andrade, Chittaranjan, primary, Appaiah, Tim, additional, Berk, Lesley, additional, Berk, Michael, additional, Bowden, Charles L., additional, Chen, Peijun, additional, Cruz, Núria, additional, Dean, Olivia, additional, Fava, Maurizio, additional, Geddes, John R., additional, Grunze, Heinz, additional, Jeon, Hong Jin, additional, Licht, Rasmus Wentzer, additional, Michalak, Erin, additional, Nierenberg, Andrew A., additional, Nolen, Willem A., additional, Otmar, Renée, additional, Sajatovic, Martha, additional, Singh, Vivek, additional, Tohen, Mauricio, additional, Vieta, Eduard, additional, and Young, Robert C., additional

Published
2015
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41. Preface

Author

Tohen, Mauricio, primary, Bowden, Charles L., additional, Nierenberg, Andrew A., additional, and Geddes, John R., additional

Published
2015
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45. Medical burden in bipolar disorder: findings from the Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder study (Bipolar CHOICE)

Author

Sylvia, Louisa G, Shelton, Richard C, Kemp, David E, Bernstein, Emily E, Friedman, Edward S, Brody, Benjamin D, McElroy, Susan L, Singh, Vivek, Tohen, Mauricio, Bowden, Charles L, Ketter, Terence A, Deckersbach, Thilo, Thase, Michael E, Reilly-Harrington, Noreen A, Nierenberg, Andrew A, Rabideau, Dustin J, Kinrys, Gustavo, Kocsis, James H, Bobo, William V, Kamali, Masoud, McInnis, Melvin G, and Calabrese, Joseph R

Published
2015
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47. Development of a Patient-Centered Software System to Facilitate Effective Management of Bipolar Disorder

Author

Bowden, Charles L, Priesmeyer, Richard, Tohen, Mauricio, Singh, Vivek, Calabrese, Joseph R, Ketter, Terry, Nierenberg, Andrew, Thase, Michael E, Siegel, Gregg, Siegel, Leslie H, Mintz, Jim, El-Mallakh, Rif S, McElroy, Susan L, and Martinez, Melissa

Subjects
Bipolar Disorder, Patient-Centered Care, Self-Management, Humans, Software, Original Research
Abstract

OBJECTIVE: Self-management of bipolar disorder (BD) is an important component of treatment. METHODS: We developed a patient-centered computational software system based on concepts from nonlinear systems (chaos) theory with mobile access to assist in managing BD known as KIOS. KIOS tracks interacting symptoms to determine theprecise state of a BD patient. Once the patient’s state is identified and the trajectory of the patient established, specific advice is generated to help manage the course of the disease. KIOS also provides analytics that can be used by clinicians and researchers to track outcomes and the course of illness. A 12-week field test was completed. RESULTS: In 20 BD subjects, use of KIOS was associated with improvements in primary symptom categories of BD. Usability and generated advice were rated as a median of 6 out of a maximum of 7. CONCLUSIONS: The KIOS focus on change illuminates problems in the same way that humans experience them, implying that the future state will be consequent to changes made to impact the current state. Randomized clinical trial is indicated.

Published
2021

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