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1. Phase transitions in random circuit sampling

Author

Morvan, A., Villalonga, B., Mi, X., Mandrà, S., Bengtsson, A., Klimov, P. V., Chen, Z., Hong, S., Erickson, C., Drozdov, I. K., Chau, J., Laun, G., Movassagh, R., Asfaw, A., Brandão, L. T. A. N., Peralta, R., Abanin, D., Acharya, R., Allen, R., Andersen, T. I., Anderson, K., Ansmann, M., Arute, F., Arya, K., Atalaya, J., Bardin, J. C., Bilmes, A., Bortoli, G., Bourassa, A., Bovaird, J., Brill, L., Broughton, M., Buckley, B. B., Buell, D. A., Burger, T., Burkett, B., Bushnell, N., Campero, J., Chang, H.-S., Chiaro, B., Chik, D., Chou, C., Cogan, J., Collins, R., Conner, P., Courtney, W., Crook, A. L., Curtin, B., Debroy, D. M., Barba, A. Del Toro, Demura, S., Paolo, A. Di, Dunsworth, A., Faoro, L., Farhi, E., Fatemi, R., Ferreira, V. S., Burgos, L. Flores, Forati, E., Fowler, A. G., Foxen, B., Garcia, G., Genois, É., Giang, W., Gidney, C., Gilboa, D., Giustina, M., Gosula, R., Dau, A. Grajales, Gross, J. A., Habegger, S., Hamilton, M. C., Hansen, M., Harrigan, M. P., Harrington, S. D., Heu, P., Hoffmann, M. R., Huang, T., Huff, A., Huggins, W. J., Ioffe, L. B., Isakov, S. V., Iveland, J., Jeffrey, E., Jiang, Z., Jones, C., Juhas, P., Kafri, D., Khattar, T., Khezri, M., Kieferová, M., Kim, S., Kitaev, A., Klots, A. R., Korotkov, A. N., Kostritsa, F., Kreikebaum, J. M., Landhuis, D., Laptev, P., Lau, K.-M., Laws, L., Lee, J., Lee, K. W., Lensky, Y. D., Lester, B. J., Lill, A. T., Liu, W., Livingston, W. P., Locharla, A., Malone, F. D., Martin, O., Martin, S., McClean, J. R., McEwen, M., Miao, K. C., Mieszala, A., Montazeri, S., Mruczkiewicz, W., Naaman, O., Neeley, M., Neill, C., Nersisyan, A., Newman, M., Ng, J. H., Nguyen, A., Nguyen, M., Niu, M. Yuezhen, O’Brien, T. E., Omonije, S., Opremcak, A., Petukhov, A., Potter, R., Pryadko, L. P., Quintana, C., Rhodes, D. M., Rocque, C., Rosenberg, E., Rubin, N. C., Saei, N., Sank, D., Sankaragomathi, K., Satzinger, K. J., Schurkus, H. F., Schuster, C., Shearn, M. J., Shorter, A., Shutty, N., Shvarts, V., Sivak, V., Skruzny, J., Smith, W. C., Somma, R. D., Sterling, G., Strain, D., Szalay, M., Thor, D., Torres, A., Vidal, G., Heidweiller, C. Vollgraff, White, T., Woo, B. W. K., Xing, C., Yao, Z. J., Yeh, P., Yoo, J., Young, G., Zalcman, A., Zhang, Y., Zhu, N., Zobrist, N., Rieffel, E. G., Biswas, R., Babbush, R., Bacon, D., Hilton, J., Lucero, E., Neven, H., Megrant, A., Kelly, J., Roushan, P., Aleiner, I., Smelyanskiy, V., Kechedzhi, K., Chen, Y., and Boixo, S.

Published
2024
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2. Stable Quantum-Correlated Many Body States through Engineered Dissipation

Author

Mi, X., Michailidis, A. A., Shabani, S., Miao, K. C., Klimov, P. V., Lloyd, J., Rosenberg, E., Acharya, R., Aleiner, I., Andersen, T. I., Ansmann, M., Arute, F., Arya, K., Asfaw, A., Atalaya, J., Bardin, J. C., Bengtsson, A., Bortoli, G., Bourassa, A., Bovaird, J., Brill, L., Broughton, M., Buckley, B. B., Buell, D. A., Burger, T., Burkett, B., Bushnell, N., Chen, Z., Chiaro, B., Chik, D., Chou, C., Cogan, J., Collins, R., Conner, P., Courtney, W., Crook, A. L., Curtin, B., Dau, A. G., Debroy, D. M., Barba, A. Del Toro, Demura, S., Di Paolo, A., Drozdov, I. K., Dunsworth, A., Erickson, C., Faoro, L., Farhi, E., Fatemi, R., Ferreira, V. S., Forati, L. F. Burgos E., Fowler, A. G., Foxen, B., Genois, E., Giang, W., Gidney, C., Gilboa, D., Giustina, M., Gosula, R., Gross, J. A., Habegger, S., Hamilton, M. C., Hansen, M., Harrigan, M. P., Harrington, S. D., Heu, P., Hoffmann, M. R., Hong, S., Huang, T., Huff, A., Huggins, W. J., Ioffe, L. B., Isakov, S. V., Iveland, J., Jeffrey, E., Jiang, Z., Jones, C., Juhas, P., Kafri, D., Kechedzhi, K., Khattar, T., Khezri, M., Kieferova, M., Kim, S., Kitaev, A., Klots, A. R., Korotkov, A. N., Kostritsa, F., Kreikebaum, J. M., Landhuis, D., Laptev, P., Lau, K. -M., Laws, L., Lee, J., Lee, K. W., Lensky, Y. D., Lester, B. J., Lill, A. T., Liu, W., Locharla, A., Malone, F. D., Martin, O., McClean, J. R., McEwen, M., Mieszala, A., Montazeri, S., Morvan, A., Movassagh, R., Mruczkiewicz, W., Neeley, M., Neill, C., Nersisyan, A., Newman, M., Ng, J. H., Nguyen, A., Nguyen, M., Niu, M. Y., OBrien, T. E., Opremcak, A., Petukhov, A., Potter, R., Pryadko, L. P., Quintana, C., Rocque, C., Rubin, N. C., Saei, N., Sank, D., Sankaragomathi, K., Satzinger, K. J., Schurkus, H. F., Schuster, C., Shearn, M. J., Shorter, A., Shutty, N., Shvarts, V., Skruzny, J., Smith, W. C., Somma, R., Sterling, G., Strain, D., Szalay, M., Torres, A., Vidal, G., Villalonga, B., Heidweiller, C. V., White, T., Woo, B. W. K., Xing, C., Yao, Z. J., Yeh, P., Yoo, J., Young, G., Zalcman, A., Zhang, Y., Zhu, N., Zobrist, N., Neven, H., Babbush, R., Bacon, D., Boixo, S., Hilton, J., Lucero, E., Megrant, A., Kelly, J., Chen, Y., Roushan, P., Smelyanskiy, V., and Abanin, D. A.

Subjects
Quantum Physics
Abstract

Engineered dissipative reservoirs have the potential to steer many-body quantum systems toward correlated steady states useful for quantum simulation of high-temperature superconductivity or quantum magnetism. Using up to 49 superconducting qubits, we prepared low-energy states of the transverse-field Ising model through coupling to dissipative auxiliary qubits. In one dimension, we observed long-range quantum correlations and a ground-state fidelity of 0.86 for 18 qubits at the critical point. In two dimensions, we found mutual information that extends beyond nearest neighbors. Lastly, by coupling the system to auxiliaries emulating reservoirs with different chemical potentials, we explored transport in the quantum Heisenberg model. Our results establish engineered dissipation as a scalable alternative to unitary evolution for preparing entangled many-body states on noisy quantum processors.

Published
2023
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3. Phase transition in Random Circuit Sampling

Author

Morvan, A., Villalonga, B., Mi, X., Mandrà, S., Bengtsson, A., Klimov, P. V., Chen, Z., Hong, S., Erickson, C., Drozdov, I. K., Chau, J., Laun, G., Movassagh, R., Asfaw, A., Brandão, L. T. A. N., Peralta, R., Abanin, D., Acharya, R., Allen, R., Andersen, T. I., Anderson, K., Ansmann, M., Arute, F., Arya, K., Atalaya, J., Bardin, J. C., Bilmes, A., Bortoli, G., Bourassa, A., Bovaird, J., Brill, L., Broughton, M., Buckley, B. B., Buell, D. A., Burger, T., Burkett, B., Bushnell, N., Campero, J., Chang, H. S., Chiaro, B., Chik, D., Chou, C., Cogan, J., Collins, R., Conner, P., Courtney, W., Crook, A. L., Curtin, B., Debroy, D. M., Barba, A. Del Toro, Demura, S., Di Paolo, A., Dunsworth, A., Faoro, L., Farhi, E., Fatemi, R., Ferreira, V. S., Burgos, L. Flores, Forati, E., Fowler, A. G., Foxen, B., Garcia, G., Genois, E., Giang, W., Gidney, C., Gilboa, D., Giustina, M., Gosula, R., Dau, A. Grajales, Gross, J. A., Habegger, S., Hamilton, M. C., Hansen, M., Harrigan, M. P., Harrington, S. D., Heu, P., Hoffmann, M. R., Huang, T., Huff, A., Huggins, W. J., Ioffe, L. B., Isakov, S. V., Iveland, J., Jeffrey, E., Jiang, Z., Jones, C., Juhas, P., Kafri, D., Khattar, T., Khezri, M., Kieferová, M., Kim, S., Kitaev, A., Klots, A. R., Korotkov, A. N., Kostritsa, F., Kreikebaum, J. M., Landhuis, D., Laptev, P., Lau, K. -M., Laws, L., Lee, J., Lee, K. W., Lensky, Y. D., Lester, B. J., Lill, A. T., Liu, W., Livingston, W. P., Locharla, A., Malone, F. D., Martin, O., Martin, S., McClean, J. R., McEwen, M., Miao, K. C., Mieszala, A., Montazeri, S., Mruczkiewicz, W., Naaman, O., Neeley, M., Neill, C., Nersisyan, A., Newman, M., Ng, J. H., Nguyen, A., Nguyen, M., Niu, M. Yuezhen, O'Brien, T. E., Omonije, S., Opremcak, A., Petukhov, A., Potter, R., Pryadko, L. P., Quintana, C., Rhodes, D. M., Rosenberg, E., Rocque, C., Roushan, P., Rubin, N. C., Saei, N., Sank, D., Sankaragomathi, K., Satzinger, K. J., Schurkus, H. F., Schuster, C., Shearn, M. J., Shorter, A., Shutty, N., Shvarts, V., Sivak, V., Skruzny, J., Smith, W. C., Somma, R. D., Sterling, G., Strain, D., Szalay, M., Thor, D., Torres, A., Vidal, G., Heidweiller, C. Vollgraff, White, T., Woo, B. W. K., Xing, C., Yao, Z. J., Yeh, P., Yoo, J., Young, G., Zalcman, A., Zhang, Y., Zhu, N., Zobrist, N., Rieffel, E. G., Biswas, R., Babbush, R., Bacon, D., Hilton, J., Lucero, E., Neven, H., Megrant, A., Kelly, J., Aleiner, I., Smelyanskiy, V., Kechedzhi, K., Chen, Y., and Boixo, S.

Subjects
Quantum Physics
Abstract

Undesired coupling to the surrounding environment destroys long-range correlations on quantum processors and hinders the coherent evolution in the nominally available computational space. This incoherent noise is an outstanding challenge to fully leverage the computation power of near-term quantum processors. It has been shown that benchmarking Random Circuit Sampling (RCS) with Cross-Entropy Benchmarking (XEB) can provide a reliable estimate of the effective size of the Hilbert space coherently available. The extent to which the presence of noise can trivialize the outputs of a given quantum algorithm, i.e. making it spoofable by a classical computation, is an unanswered question. Here, by implementing an RCS algorithm we demonstrate experimentally that there are two phase transitions observable with XEB, which we explain theoretically with a statistical model. The first is a dynamical transition as a function of the number of cycles and is the continuation of the anti-concentration point in the noiseless case. The second is a quantum phase transition controlled by the error per cycle; to identify it analytically and experimentally, we create a weak link model which allows varying the strength of noise versus coherent evolution. Furthermore, by presenting an RCS experiment with 67 qubits at 32 cycles, we demonstrate that the computational cost of our experiment is beyond the capabilities of existing classical supercomputers, even when accounting for the inevitable presence of noise. Our experimental and theoretical work establishes the existence of transitions to a stable computationally complex phase that is reachable with current quantum processors.

Published
2023

4. Purification-based quantum error mitigation of pair-correlated electron simulations

Author

O'Brien, T. E., Anselmetti, G., Gkritsis, F., Elfving, V. E., Polla, S., Huggins, W. J., Oumarou, O., Kechedzhi, K., Abanin, D., Acharya, R., Aleiner, I., Allen, R., Andersen, T. I., Anderson, K., Ansmann, M., Arute, F., Arya, K., Asfaw, A., Atalaya, J., Bacon, D., Bardin, J. C., Bengtsson, A., Boixo, S., Bortoli, G., Bourassa, A., Bovaird, J., Brill, L., Broughton, M., Buckley, B., Buell, D. A., Burger, T., Burkett, B., Bushnell, N., Campero, J., Chen, Y., Chen, Z., Chiaro, B., Chik, D., Cogan, J., Collins, R., Conner, P., Courtney, W., Crook, A. L., Curtin, B., Debroy, D. M., Demura, S., Drozdov, I., Dunsworth, A., Erickson, C., Faoro, L., Farhi, E., Fatemi, R., Ferreira, V. S., Burgos, L. Flores, Forati, E., Fowler, A. G., Foxen, B., Giang, W., Gidney, C., Gilboa, D., Giustina, M., Gosula, R., Dau, A. Grajales, Gross, J. A., Habegger, S., Hamilton, M. C., Hansen, M., Harrigan, M. P., Harrington, S. D., Heu, P., Hilton, J., Hoffmann, M. R., Hong, S., Huang, T., Huff, A., Ioffe, L. B., Isakov, S. V., Iveland, J., Jeffrey, E., Jiang, Z., Jones, C., Juhas, P., Kafri, D., Kelly, J., Khattar, T., Khezri, M., Kieferová, M., Kim, S., Klimov, P. V., Klots, A. R., Kothari, R., Korotkov, A. N., Kostritsa, F., Kreikebaum, J. M., Landhuis, D., Laptev, P., Lau, K., Laws, L., Lee, J., Lee, K., Lester, B. J., Lill, A. T., Liu, W., Livingston, W. P., Locharla, A., Lucero, E., Malone, F. D., Mandra, S., Martin, O., Martin, S., McClean, J. R., McCourt, T., McEwen, M., Megrant, A., Mi, X., Mieszala, A., Miao, K. C., Mohseni, M., Montazeri, S., Morvan, A., Movassagh, R., Mruczkiewicz, W., Naaman, O., Neeley, M., Neill, C., Nersisyan, A., Neven, H., Newman, M., Ng, J. H., Nguyen, A., Nguyen, M., Niu, M. Y., Omonije, S., Opremcak, A., Petukhov, A., Potter, R., Pryadko, L. P., Quintana, C., Rocque, C., Roushan, P., Saei, N., Sank, D., Sankaragomathi, K., Satzinger, K. J., Schurkus, H. F., Schuster, C., Shearn, M. J., Shorter, A., Shutty, N., Shvarts, V., Skruzny, J., Smelyanskiy, V., Smith, W. C., Somma, R., Sterling, G., Strain, D., Szalay, M., Thor, D., Torres, A., Vidal, G., Villalonga, B., Heidweiller, C. Vollgraff, White, T., Woo, B. W. K., Xing, C., Yao, Z. J., Yeh, P., Yoo, J., Young, G., Zalcman, A., Zhang, Y., Zhu, N., Zobrist, N., Gogolin, C., Babbush, R., and Rubin, N. C.

Subjects
Quantum Physics
Abstract

An important measure of the development of quantum computing platforms has been the simulation of increasingly complex physical systems. Prior to fault-tolerant quantum computing, robust error mitigation strategies are necessary to continue this growth. Here, we study physical simulation within the seniority-zero electron pairing subspace, which affords both a computational stepping stone to a fully correlated model, and an opportunity to validate recently introduced ``purification-based'' error-mitigation strategies. We compare the performance of error mitigation based on doubling quantum resources in time (echo verification) or in space (virtual distillation), on up to $20$ qubits of a superconducting qubit quantum processor. We observe a reduction of error by one to two orders of magnitude below less sophisticated techniques (e.g. post-selection); the gain from error mitigation is seen to increase with the system size. Employing these error mitigation strategies enables the implementation of the largest variational algorithm for a correlated chemistry system to-date. Extrapolating performance from these results allows us to estimate minimum requirements for a beyond-classical simulation of electronic structure. We find that, despite the impressive gains from purification-based error mitigation, significant hardware improvements will be required for classically intractable variational chemistry simulations., Comment: 10 pages, 13 page supplementary material, 12 figures. Experimental data available at https://doi.org/10.5281/zenodo.7225821

Published
2022
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5. Purification-based quantum error mitigation of pair-correlated electron simulations

Author

O’Brien, T. E., Anselmetti, G., Gkritsis, F., Elfving, V. E., Polla, S., Huggins, W. J., Oumarou, O., Kechedzhi, K., Abanin, D., Acharya, R., Aleiner, I., Allen, R., Andersen, T. I., Anderson, K., Ansmann, M., Arute, F., Arya, K., Asfaw, A., Atalaya, J., Bardin, J. C., Bengtsson, A., Bortoli, G., Bourassa, A., Bovaird, J., Brill, L., Broughton, M., Buckley, B., Buell, D. A., Burger, T., Burkett, B., Bushnell, N., Campero, J., Chen, Z., Chiaro, B., Chik, D., Cogan, J., Collins, R., Conner, P., Courtney, W., Crook, A. L., Curtin, B., Debroy, D. M., Demura, S., Drozdov, I., Dunsworth, A., Erickson, C., Faoro, L., Farhi, E., Fatemi, R., Ferreira, V. S., Flores Burgos, L., Forati, E., Fowler, A. G., Foxen, B., Giang, W., Gidney, C., Gilboa, D., Giustina, M., Gosula, R., Grajales Dau, A., Gross, J. A., Habegger, S., Hamilton, M. C., Hansen, M., Harrigan, M. P., Harrington, S. D., Heu, P., Hoffmann, M. R., Hong, S., Huang, T., Huff, A., Ioffe, L. B., Isakov, S. V., Iveland, J., Jeffrey, E., Jiang, Z., Jones, C., Juhas, P., Kafri, D., Khattar, T., Khezri, M., Kieferová, M., Kim, S., Klimov, P. V., Klots, A. R., Korotkov, A. N., Kostritsa, F., Kreikebaum, J. M., Landhuis, D., Laptev, P., Lau, K.-M., Laws, L., Lee, J., Lee, K., Lester, B. J., Lill, A. T., Liu, W., Livingston, W. P., Locharla, A., Malone, F. D., Mandrà, S., Martin, O., Martin, S., McClean, J. R., McCourt, T., McEwen, M., Mi, X., Mieszala, A., Miao, K. C., Mohseni, M., Montazeri, S., Morvan, A., Movassagh, R., Mruczkiewicz, W., Naaman, O., Neeley, M., Neill, C., Nersisyan, A., Newman, M., Ng, J. H., Nguyen, A., Nguyen, M., Niu, M. Y., Omonije, S., Opremcak, A., Petukhov, A., Potter, R., Pryadko, L. P., Quintana, C., Rocque, C., Roushan, P., Saei, N., Sank, D., Sankaragomathi, K., Satzinger, K. J., Schurkus, H. F., Schuster, C., Shearn, M. J., Shorter, A., Shutty, N., Shvarts, V., Skruzny, J., Smith, W. C., Somma, R. D., Sterling, G., Strain, D., Szalay, M., Thor, D., Torres, A., Vidal, G., Villalonga, B., Vollgraff Heidweiller, C., White, T., Woo, B. W. K., Xing, C., Yao, Z. J., Yeh, P., Yoo, J., Young, G., Zalcman, A., Zhang, Y., Zhu, N., Zobrist, N., Bacon, D., Boixo, S., Chen, Y., Hilton, J., Kelly, J., Lucero, E., Megrant, A., Neven, H., Smelyanskiy, V., Gogolin, C., Babbush, R., and Rubin, N. C.

Published
2023
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6. Formation of robust bound states of interacting microwave photons

Author

Morvan, A, Andersen, TI, Mi, X, Neill, C, Petukhov, A, Kechedzhi, K, Abanin, DA, Michailidis, A, Acharya, R, Arute, F, Arya, K, Asfaw, A, Atalaya, J, Bardin, JC, Basso, J, Bengtsson, A, Bortoli, G, Bourassa, A, Bovaird, J, Brill, L, Broughton, M, Buckley, BB, Buell, DA, Burger, T, Burkett, B, Bushnell, N, Chen, Z, Chiaro, B, Collins, R, Conner, P, Courtney, W, Crook, AL, Curtin, B, Debroy, DM, Del Toro Barba, A, Demura, S, Dunsworth, A, Eppens, D, Erickson, C, Faoro, L, Farhi, E, Fatemi, R, Flores Burgos, L, Forati, E, Fowler, AG, Foxen, B, Giang, W, Gidney, C, Gilboa, D, Giustina, M, Grajales Dau, A, Gross, JA, Habegger, S, Hamilton, MC, Harrigan, MP, Harrington, SD, Hoffmann, M, Hong, S, Huang, T, Huff, A, Huggins, WJ, Isakov, SV, Iveland, J, Jeffrey, E, Jiang, Z, Jones, C, Juhas, P, Kafri, D, Khattar, T, Khezri, M, Kieferová, M, Kim, S, Kitaev, AY, Klimov, PV, Klots, AR, Korotkov, AN, Kostritsa, F, Kreikebaum, JM, Landhuis, D, Laptev, P, Lau, K-M, Laws, L, Lee, J, Lee, KW, Lester, BJ, Lill, AT, Liu, W, Locharla, A, Malone, F, Martin, O, McClean, JR, McEwen, M, Meurer Costa, B, Miao, KC, Mohseni, M, Montazeri, S, Mount, E, Mruczkiewicz, W, Naaman, O, and Neeley, M

Subjects
Quantum Physics, Physical Sciences, Photons, Microwaves, Electrons, Fees and Charges, Reproduction, General Science & Technology
Abstract

Systems of correlated particles appear in many fields of modern science and represent some of the most intractable computational problems in nature. The computational challenge in these systems arises when interactions become comparable to other energy scales, which makes the state of each particle depend on all other particles1. The lack of general solutions for the three-body problem and acceptable theory for strongly correlated electrons shows that our understanding of correlated systems fades when the particle number or the interaction strength increases. One of the hallmarks of interacting systems is the formation of multiparticle bound states2-9. Here we develop a high-fidelity parameterizable fSim gate and implement the periodic quantum circuit of the spin-½ XXZ model in a ring of 24 superconducting qubits. We study the propagation of these excitations and observe their bound nature for up to five photons. We devise a phase-sensitive method for constructing the few-body spectrum of the bound states and extract their pseudo-charge by introducing a synthetic flux. By introducing interactions between the ring and additional qubits, we observe an unexpected resilience of the bound states to integrability breaking. This finding goes against the idea that bound states in non-integrable systems are unstable when their energies overlap with the continuum spectrum. Our work provides experimental evidence for bound states of interacting photons and discovers their stability beyond the integrability limit.

Published
2022

8. Purification-based quantum error mitigation of pair-correlated electron simulations

Author

O’Brien, TE, Anselmetti, G, Gkritsis, F, Elfving, VE, Polla, S, Huggins, WJ, Oumarou, O, Kechedzhi, K, Abanin, D, Acharya, R, Aleiner, I, Allen, R, Andersen, TI, Anderson, K, Ansmann, M, Arute, F, Arya, K, Asfaw, A, Atalaya, J, Bardin, JC, Bengtsson, A, Bortoli, G, Bourassa, A, Bovaird, J, Brill, L, Broughton, M, Buckley, B, Buell, DA, Burger, T, Burkett, B, Bushnell, N, Campero, J, Chen, Z, Chiaro, B, Chik, D, Cogan, J, Collins, R, Conner, P, Courtney, W, Crook, AL, Curtin, B, Debroy, DM, Demura, S, Drozdov, I, Dunsworth, A, Erickson, C, Faoro, L, Farhi, E, Fatemi, R, Ferreira, VS, Flores Burgos, L, Forati, E, Fowler, AG, Foxen, B, Giang, W, Gidney, C, Gilboa, D, Giustina, M, Gosula, R, Grajales Dau, A, Gross, JA, Habegger, S, Hamilton, MC, Hansen, M, Harrigan, MP, Harrington, SD, Heu, P, Hoffmann, MR, Hong, S, Huang, T, Huff, A, Ioffe, LB, Isakov, SV, Iveland, J, Jeffrey, E, Jiang, Z, Jones, C, Juhas, P, Kafri, D, Khattar, T, Khezri, M, Kieferová, M, Kim, S, Klimov, PV, Klots, AR, Korotkov, AN, Kostritsa, F, Kreikebaum, JM, Landhuis, D, Laptev, P, Lau, KM, Laws, L, Lee, J, Lee, K, Lester, BJ, Lill, AT, Liu, W, Livingston, WP, Locharla, A, Malone, FD, O’Brien, TE, Anselmetti, G, Gkritsis, F, Elfving, VE, Polla, S, Huggins, WJ, Oumarou, O, Kechedzhi, K, Abanin, D, Acharya, R, Aleiner, I, Allen, R, Andersen, TI, Anderson, K, Ansmann, M, Arute, F, Arya, K, Asfaw, A, Atalaya, J, Bardin, JC, Bengtsson, A, Bortoli, G, Bourassa, A, Bovaird, J, Brill, L, Broughton, M, Buckley, B, Buell, DA, Burger, T, Burkett, B, Bushnell, N, Campero, J, Chen, Z, Chiaro, B, Chik, D, Cogan, J, Collins, R, Conner, P, Courtney, W, Crook, AL, Curtin, B, Debroy, DM, Demura, S, Drozdov, I, Dunsworth, A, Erickson, C, Faoro, L, Farhi, E, Fatemi, R, Ferreira, VS, Flores Burgos, L, Forati, E, Fowler, AG, Foxen, B, Giang, W, Gidney, C, Gilboa, D, Giustina, M, Gosula, R, Grajales Dau, A, Gross, JA, Habegger, S, Hamilton, MC, Hansen, M, Harrigan, MP, Harrington, SD, Heu, P, Hoffmann, MR, Hong, S, Huang, T, Huff, A, Ioffe, LB, Isakov, SV, Iveland, J, Jeffrey, E, Jiang, Z, Jones, C, Juhas, P, Kafri, D, Khattar, T, Khezri, M, Kieferová, M, Kim, S, Klimov, PV, Klots, AR, Korotkov, AN, Kostritsa, F, Kreikebaum, JM, Landhuis, D, Laptev, P, Lau, KM, Laws, L, Lee, J, Lee, K, Lester, BJ, Lill, AT, Liu, W, Livingston, WP, Locharla, A, and Malone, FD

Abstract

An important measure of the development of quantum computing platforms has been the simulation of increasingly complex physical systems. Before fault-tolerant quantum computing, robust error-mitigation strategies were necessary to continue this growth. Here, we validate recently introduced error-mitigation strategies that exploit the expectation that the ideal output of a quantum algorithm would be a pure state. We consider the task of simulating electron systems in the seniority-zero subspace where all electrons are paired with their opposite spin. This affords a computational stepping stone to a fully correlated model. We compare the performance of error mitigations on the basis of doubling quantum resources in time or in space on up to 20 qubits of a superconducting qubit quantum processor. We observe a reduction of error by one to two orders of magnitude below less sophisticated techniques such as postselection. We study how the gain from error mitigation scales with the system size and observe a polynomial suppression of error with increased resources. Extrapolation of our results indicates that substantial hardware improvements will be required for classically intractable variational chemistry simulations.

Published
2023

9. Stable Quantum-Correlated Many Body States via Engineered Dissipation

Author

Mi, X., Michailidis, A. A., Shabani, S., Miao, K. C., Klimov, P. V., Lloyd, J., Rosenberg, E., Acharya, R., Aleiner, I., Andersen, T. I., Ansmann, M., Arute, F., Arya, K., Asfaw, A., Atalaya, J., Bardin, J. C., Bengtsson, A., Bortoli, G., Bourassa, A., Bovaird, J., Brill, L., Broughton, M., Buckley, B. B., Buell, D. A., Burger, T., Burkett, B., Bushnell, N., Chen, Z., Chiaro, B., Chik, D., Chou, C., Cogan, J., Collins, R., Conner, P., Courtney, W., Crook, A. L., Curtin, B., Dau, A. G., Debroy, D. M., Barba, A. Del Toro, Demura, S., Di Paolo, A., Drozdov, I. K., Dunsworth, A., Erickson, C., Faoro, L., Farhi, E., Fatemi, R., Ferreira, V. S., Forati, L. F. Burgos E., Fowler, A. G., Foxen, B., Genois, E., Giang, W., Gidney, C., Gilboa, D., Giustina, M., Gosula, R., Gross, J. A., Habegger, S., Hamilton, M. C., Hansen, M., Harrigan, M. P., Harrington, S. D., Heu, P., Hoffmann, M. R., Hong, S., Huang, T., Huff, A., Huggins, W. J., Ioffe, L. B., Isakov, S. V., Iveland, J., Jeffrey, E., Jiang, Z., Jones, C., Juhas, P., Kafri, D., Kechedzhi, K., Khattar, T., Khezri, M., Kieferova, M., Kim, S., Kitaev, A., Klots, A. R., Korotkov, A. N., Kostritsa, F., Kreikebaum, J. M., Landhuis, D., Laptev, P., Lau, K. -M., Laws, L., Lee, J., Lee, K. W., Lensky, Y. D., Lester, B. J., Lill, A. T., Liu, W., Locharla, A., Malone, F. D., Martin, O., McClean, J. R., McEwen, M., Mieszala, A., Montazeri, S., Morvan, A., Movassagh, R., Mruczkiewicz, W., Neeley, M., Neill, C., Nersisyan, A., Newman, M., Ng, J. H., Nguyen, A., Nguyen, M., Niu, M. Y., OBrien, T. E., Opremcak, A., Petukhov, A., Potter, R., Pryadko, L. P., Quintana, C., Rocque, C., Rubin, N. C., Saei, N., Sank, D., Sankaragomathi, K., Satzinger, K. J., Schurkus, H. F., Schuster, C., Shearn, M. J., Shorter, A., Shutty, N., Shvarts, V., Skruzny, J., Smith, W. C., Somma, R., Sterling, G., Strain, D., Szalay, M., Torres, A., Vidal, G., Villalonga, B., Heidweiller, C. V., White, T., Woo, B. W. K., Xing, C., Yao, Z. J., Yeh, P., Yoo, J., Young, G., Zalcman, A., Zhang, Y., Zhu, N., Zobrist, N., Neven, H., Babbush, R., Bacon, D., Boixo, S., Hilton, J., Lucero, E., Megrant, A., Kelly, J., Chen, Y., Roushan, P., Smelyanskiy, V., and Abanin, D. A.

Subjects
Quantum Physics, FOS: Physical sciences, Quantum Physics (quant-ph)
Abstract

Engineered dissipative reservoirs can steer many-body quantum systems toward correlated steady states useful for quantum simulation of high-temperature superconductivity or quantum magnetism. Using 49 superconducting qubits, we prepare low-energy states of the transverse-field Ising model via coupling to dissipative auxiliary qubits. In 1D, we observe long-range quantum correlations and a ground state fidelity that depends weakly on system sizes. In 2D, we find mutual information that extends beyond nearest neighbors. Lastly, by coupling the system to auxiliaries emulating reservoirs with different chemical potentials, we discover a new spin transport regime in the quantum Heisenberg model. Our results establish engineered dissipation as a scalable alternative to unitary evolution for preparing entangled many-body states on noisy quantum processors, and an essential tool for investigating nonequilibrium quantum phenomena.

Published
2023

10. Measurement-induced entanglement and teleportation on a noisy quantum processor.

Author

Hoke, J. C., Ippoliti, M., Rosenberg, E., Abanin, D., Acharya, R., Andersen, T. I., Ansmann, M., Arute, F., Arya, K., Asfaw, A., Atalaya, J., Bardin, J. C., Bengtsson, A., Bortoli, G., Bourassa, A., Bovaird, J., Brill, L., Broughton, M., Buckley, B. B., and Buell, D. A.

Abstract

Measurement has a special role in quantum theory1: by collapsing the wavefunction, it can enable phenomena such as teleportation2 and thereby alter the ‘arrow of time’ that constrains unitary evolution. When integrated in many-body dynamics, measurements can lead to emergent patterns of quantum information in space–time3–10 that go beyond the established paradigms for characterizing phases, either in or out of equilibrium11–13. For present-day noisy intermediate-scale quantum (NISQ) processors14, the experimental realization of such physics can be problematic because of hardware limitations and the stochastic nature of quantum measurement. Here we address these experimental challenges and study measurement-induced quantum information phases on up to 70 superconducting qubits. By leveraging the interchangeability of space and time, we use a duality mapping9,15–17 to avoid mid-circuit measurement and access different manifestations of the underlying phases, from entanglement scaling3,4 to measurement-induced teleportation18. We obtain finite-sized signatures of a phase transition with a decoding protocol that correlates the experimental measurement with classical simulation data. The phases display remarkably different sensitivity to noise, and we use this disparity to turn an inherent hardware limitation into a useful diagnostic. Our work demonstrates an approach to realizing measurement-induced physics at scales that are at the limits of current NISQ processors.Measurement-induced phases of quantum information have been observed in a system of 70 superconducting qubits. [ABSTRACT FROM AUTHOR]

Published
2023
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17. A Modification to the Assessment of Problem-Solving in Play to Enhance Its Utility: Evaluation of Validity, Responsiveness, and Reliability.

Author

Molinini RM, Koziol NA, Inamdar K, Rhee C, Salgaonkar A, Harbourne RT, Hsu LY, Westcott Mccoy S, Lobo MA, Bovaird J, Burnsed J, Spence C, Stevenson R, and Dusing SC

Subjects
Humans, Reproducibility of Results, Infant, Child, Preschool, Female, Male, Child Development physiology, Developmental Disabilities, Problem Solving, Psychometrics, Play and Playthings
Abstract

Purpose: This study investigated the psychometric properties of a 4-second interval scoring modification of the Assessment of Problem-Solving in Play (ie, Assessment of Problem-Solving in Play 4-second interval scoring [APSP-4])., Methods: A total of 95 children (3-48 months) with or at high risk for neuromotor delay were assessed with the APSP-4 and Bayley Scales of Infant and Toddler Development-III (Bayley). APSP-4 and Bayley cognitive raw scores were compared by age (construct validity) and over time (responsiveness). Twenty percent of videos were scored twice for intra- and interrater reliability., Results: The APSP-4 demonstrated excellent interrater (intraclass correlations [ICCs] ≥ 0.96) and intrarater (ICCs ≥ 0.99) reliability and performed similar to Bayley cognitive raw scores at different ages ( r s > 0.5), and over time ( r  = 0.81). The motor delay had similar effects on APSP-4 and Bayley scores., Conclusions: Results support the validity and reliability evidence of the APSP-4 for use over time in tracking problem-solving skills in young children aged 3 to 48 months. Future research investigating clinical implementation of the APSP-4 is needed., (Copyright © 2024 Academy of Pediatric Physical Therapy of the American Physical Therapy Association.)

Published
2024
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18. Dynamics of magnetization at infinite temperature in a Heisenberg spin chain.

Author

Rosenberg E, Andersen TI, Samajdar R, Petukhov A, Hoke JC, Abanin D, Bengtsson A, Drozdov IK, Erickson C, Klimov PV, Mi X, Morvan A, Neeley M, Neill C, Acharya R, Allen R, Anderson K, Ansmann M, Arute F, Arya K, Asfaw A, Atalaya J, Bardin JC, Bilmes A, Bortoli G, Bourassa A, Bovaird J, Brill L, Broughton M, Buckley BB, Buell DA, Burger T, Burkett B, Bushnell N, Campero J, Chang HS, Chen Z, Chiaro B, Chik D, Cogan J, Collins R, Conner P, Courtney W, Crook AL, Curtin B, Debroy DM, Barba ADT, Demura S, Di Paolo A, Dunsworth A, Earle C, Faoro L, Farhi E, Fatemi R, Ferreira VS, Burgos LF, Forati E, Fowler AG, Foxen B, Garcia G, Genois É, Giang W, Gidney C, Gilboa D, Giustina M, Gosula R, Dau AG, Gross JA, Habegger S, Hamilton MC, Hansen M, Harrigan MP, Harrington SD, Heu P, Hill G, Hoffmann MR, Hong S, Huang T, Huff A, Huggins WJ, Ioffe LB, Isakov SV, Iveland J, Jeffrey E, Jiang Z, Jones C, Juhas P, Kafri D, Khattar T, Khezri M, Kieferová M, Kim S, Kitaev A, Klots AR, Korotkov AN, Kostritsa F, Kreikebaum JM, Landhuis D, Laptev P, Lau KM, Laws L, Lee J, Lee KW, Lensky YD, Lester BJ, Lill AT, Liu W, Locharla A, Mandrà S, Martin O, Martin S, McClean JR, McEwen M, Meeks S, Miao KC, Mieszala A, Montazeri S, Movassagh R, Mruczkiewicz W, Nersisyan A, Newman M, Ng JH, Nguyen A, Nguyen M, Niu MY, O'Brien TE, Omonije S, Opremcak A, Potter R, Pryadko LP, Quintana C, Rhodes DM, Rocque C, Rubin NC, Saei N, Sank D, Sankaragomathi K, Satzinger KJ, Schurkus HF, Schuster C, Shearn MJ, Shorter A, Shutty N, Shvarts V, Sivak V, Skruzny J, Smith WC, Somma RD, Sterling G, Strain D, Szalay M, Thor D, Torres A, Vidal G, Villalonga B, Heidweiller CV, White T, Woo BWK, Xing C, Yao ZJ, Yeh P, Yoo J, Young G, Zalcman A, Zhang Y, Zhu N, Zobrist N, Neven H, Babbush R, Bacon D, Boixo S, Hilton J, Lucero E, Megrant A, Kelly J, Chen Y, Smelyanskiy V, Khemani V, Gopalakrishnan S, Prosen T, and Roushan P

Abstract

Understanding universal aspects of quantum dynamics is an unresolved problem in statistical mechanics. In particular, the spin dynamics of the one-dimensional Heisenberg model were conjectured as to belong to the Kardar-Parisi-Zhang (KPZ) universality class based on the scaling of the infinite-temperature spin-spin correlation function. In a chain of 46 superconducting qubits, we studied the probability distribution of the magnetization transferred across the chain's center, [Formula: see text]. The first two moments of [Formula: see text] show superdiffusive behavior, a hallmark of KPZ universality. However, the third and fourth moments ruled out the KPZ conjecture and allow for evaluating other theories. Our results highlight the importance of studying higher moments in determining dynamic universality classes and provide insights into universal behavior in quantum systems.

Published
2024
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19. Diagnostic Performance of Biomarkers for Bladder Cancer Detection Suitable for Community and Primary Care Settings: A Systematic Review and Meta-Analysis.

Author

Papavasiliou E, Sills VA, Calanzani N, Harrison H, Snudden C, di Martino E, Cowan A, Behiyat D, Boscott R, Tan S, Bovaird J, Stewart GD, Walter FM, and Zhou Y

Abstract

Evidence on the use of biomarkers to detect bladder cancer in the general population is scarce. This study aimed to systematically review evidence on the diagnostic performance of biomarkers which might be suitable for use in community and primary care settings [PROSPERO Registration: CRD42021258754]. Database searches on MEDLINE and EMBASE from January 2000 to May 2022 resulted in 4914 unique citations, 44 of which met inclusion criteria. Included studies reported on 112 biomarkers and combinations. Heterogeneity of designs, populations and outcomes allowed for the meta-analysis of three biomarkers identified in at least five studies (NMP-22, UroVysion, uCyt+). These three biomarkers showed similar discriminative ability (adjusted AUC estimates ranging from 0.650 to 0.707), although for NMP-22 and UroVysion there was significant unexplained heterogeneity between included studies. Narrative synthesis revealed the potential of these biomarkers for use in the general population based on their reported clinical utility, including effects on clinicians, patients, and the healthcare system. Finally, we identified some promising novel biomarkers and biomarker combinations ( N < 3 studies for each biomarker/combination) with negative predictive values of ≥90%. These biomarkers have potential for use as a triage tool in community and primary care settings for reducing unnecessary specialist referrals. Despite promising emerging evidence, further validation studies in the general population are required at different stages within the diagnostic pathway.

Published
2023
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20. The Effect of START-Play Intervention on Reaching-Related Exploratory Behaviors in Children with Neuromotor Delays: A Secondary Analysis of a Randomized Controlled Trial.

Author

Babik I, B Cunha A, Choi D, Koziol NA, T Harbourne R, C Dusing S, W McCoy S, A Bovaird J, L Willett S, and Lobo MA

Subjects
Humans, Child, Infant, Child Development, Activities of Daily Living, Early Intervention, Educational, Exploratory Behavior, Motor Skills Disorders
Abstract

Aims: Children with neuromotor delays are at risk for reaching and object exploration impairments, which may negatively affect their cognitive development and daily activity performance. This study evaluated the effectiveness of the Sitting Together And Reaching To Play (START-Play) intervention on reaching-related exploratory behaviors in children with neuromotor delays., Methods: In this randomized controlled clinical trial, 112 children ( Mean  = 10.80, SD  = 2.59 months old at baseline) with motor delays were randomly assigned to receive START-Play intervention or usual care-early intervention. Performance for ten reaching-related exploratory behaviors was assessed at baseline and 1.5, 3, 6, 12 months post-baseline. Piecewise linear mixed-effects modeling was used to evaluate short- and long-term effects of the intervention., Results: Benefits of START-Play were observed for children with significant motor delays, but not for those with mild delays. START-Play was especially beneficial for children with significant motor delays who demonstrated early mastery in the reaching assessment (i.e., object contact ≥65% of the time within 3 months after baseline); these children showed greater improvements in manual, visual, and multimodal exploration, as well as intensity of exploration across time., Conclusions: START-Play advanced the performance of reaching-related exploratory behaviors in children with significant motor delays.

Published
2023
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21. Identifying the K-12 classrooms' indoor air quality factors that affect student academic performance.

Author

Kabirikopaei A, Lau J, Nord J, and Bovaird J

Subjects
Carbon Dioxide analysis, Humans, Schools, Students, Ventilation, Academic Performance, Air Pollutants analysis, Air Pollution, Indoor analysis
Abstract

The objective of this study was to investigate associations between indoor air quality (IAQ) in K-12 classrooms and student academic performance. During the academic years 2015-2017, various IAQ factors in 220 classrooms in the US were measured seasonally, excluding summer. Measurements were taken during occupied and unoccupied times in several classrooms within each school. Occupied measurements included indoor carbon dioxide (CO 2 ) and formaldehyde concentrations, and fine and coarse particle counts. Unoccupied measurements consisted of ozone (O 3 ), carbon monoxide (CO), nitrogen dioxide (NO 2 ), and total volatile organic compounds (TVOCs) concentrations. Ventilation rates of classrooms were estimated using measured CO 2 concentrations. In addition to IAQ data, classroom aggregated student achievement scores and demographic information were collected from participating school districts. Demographic data included percentage rates of free and reduced lunch recipients (PFRL), high-performance students (PGIF), and special education students (PSPED). A multivariate linear regression analysis was used to investigate the associations between IAQ factors and student scores using demographic data as controls. The results revealed associations between student scores and ventilation system type, ventilation rates, fine particle counts, and O 3 and CO concentrations. This research provides valuable information to school districts and design engineers, enabling them to design school environments for improved student performance., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Published
2021
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22. Relation of aerobic fitness, eating behavior and physical activity to body composition in college-age women: A path analysis.

Author

Murphy C, Takahashi S, Bovaird J, and Koehler K

Subjects
Body Composition, Body Mass Index, Exercise, Feeding Behavior, Female, Humans, Physical Fitness, Students, Universities
Abstract

Objective: Given the number of college students with a normal BMI decreases 9-12% throughout the college experience, we wanted to model the traits responsible for behaviors impacting body composition in college-age women. Participants: Participants ( n  = 141) were recruited from a freshman-level nutrition course between August 2016 and May 2018. Methods: We built a path analysis model using variables from online questionnaires and lab visits. We grouped participants by median split of aerobic fitness and evaluated model fit. We defined statistical significance as p  < .05. Results: The model provided an adequate representation of the data (CFI = 0.921). Aerobic fitness was the strongest predictor of body fat ( p  < .001) in both high-fit (-0.440) and low-fit (-0.469) women. Body dissatisfaction demonstrated relationships with body fat previously established in athletes and clinical populations. Conclusion: Physical activity to improve aerobic fitness appears most effective at maintaining healthy body composition in this population.

Published
2021
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23. Measuring Early Problem-Solving in Young Children with Motor Delays: A Validation Study.

Author

Molinini RM, Koziol NA, Tripathi T, Harbourne RT, McCoy SW, Lobo MA, Bovaird J, and Dusing SC

Subjects
Child, Child Development, Child, Preschool, Developmental Disabilities diagnosis, Humans, Infant, Problem Solving, Motor Skills, Motor Skills Disorders
Abstract

Aim: There is a lack of evidence-based tools for measuring problem-solving in young children with motor delays. The purpose of this study was to evaluate the construct validity and responsiveness of the Assessment of Problem-Solving in Play., Methods: 125 young children (10.72, SD 2.62 months) with mild, moderate, and severe motor delays were assessed with the Bayley Scales of Infant and Toddler Development, Third Edition Cognitive Scale and the Assessment of Problem-Solving in Play up to 4 times over 12 months. The baseline and change over time assessment scores were compared., Results: The Assessment of Problem-Solving in Play was strongly, positively correlated with the Bayley Scales of Infant and Toddler Development, Third Edition Cognitive Scale raw scores at baseline ( r =.83, p <.001) and for changes in scores across time ( r =.64, p <.001). On average, participants demonstrated positive change in problem-solving scores across time. Participants with severe motor delay scored lower at baseline and changed less as compared to other participants., Conclusions: Results provide evidence for the construct validity and responsiveness of the Assessment of Problem-Solving in Play scores in quantifying problem-solving in young children with motor delays 7-27 months of age.

Published
2021
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24. Sitting Together And Reaching To Play (START-Play): Protocol for a Multisite Randomized Controlled Efficacy Trial on Intervention for Infants With Neuromotor Disorders.

Author

Harbourne RT, Dusing SC, Lobo MA, Westcott-McCoy S, Bovaird J, Sheridan S, Galloway JC, Chang HJ, Hsu LY, Koziol N, Marcinowski EC, and Babik I

Subjects
Female, Humans, Infant, Longitudinal Studies, Male, Research Design, Child Development, Motor Skills Disorders rehabilitation, Physical Therapy Modalities, Play and Playthings
Abstract

Background: There is limited research examining the efficacy of early physical therapy on infants with neuromotor dysfunction. In addition, most early motor interventions have not been directly linked to learning, despite the clear association between motor activity and cognition during infancy., Objective: The aim of this project is to evaluate the efficacy of Sitting Together And Reaching To Play (START-Play), an intervention designed to target sitting, reaching, and motor-based problem solving to advance global development in infants with motor delays or neuromotor dysfunction., Design: This study is a longitudinal multisite randomized controlled trial. Infants in the START-Play group are compared to infants receiving usual care in early intervention (EI)., Setting: The research takes place in homes in Pennsylvania, Delaware, Washington, and Virginia., Participants: There will be 140 infants with neuromotor dysfunction participating, beginning between 7 to 16 months of age. Infants will have motor delays and emerging sitting skill., Intervention: START-Play provides individualized twice-weekly home intervention for 12 weeks with families to enhance cognition through sitting, reaching, and problem-solving activities for infants. Ten interventionists provide the intervention, with each child assigned 1 therapist., Measurements: The primary outcome measure is the Bayley III Scales of Infant Development. Secondary measures include change in the Early Problem Solving Indicator, change in the Gross Motor Function Measure, and change in the type and duration of toy contacts during reaching. Additional measures include sitting posture control and parent-child interaction., Limitations: Limitations include variability in usual EI care and the lack of blinding for interventionists and families., Conclusions: This study describes usual care in EI across 4 US regions and compares outcomes of the START-Play intervention to usual care.

Published
2018
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25. Regression-based multi-trait QTL mapping using a structural equation model.

Author

Mi X, Eskridge K, Wang D, Baenziger PS, Campbell BT, Gill KS, Dweikat I, and Bovaird J

Subjects
Chromosomes, Plant genetics, Crosses, Genetic, Genotype, Models, Statistical, Triticum genetics, Quantitative Trait Loci, Regression Analysis
Abstract

Quantitative trait loci (QTL) mapping often results in data on a number of traits that have well-established causal relationships. Many multi-trait QTL mapping methods that account for the correlation among multiple traits have been developed to improve the statistical power and the precision of QTL parameter estimation. However, none of these methods are capable of incorporating the causal structure among the traits. Consequently, genetic functions of the QTL may not be fully understood. Structural equation modeling (SEM) allows researchers to explicitly characterize the causal structure among the variables and to decompose effects into direct, indirect, and total effects. In this paper, we developed a multi-trait SEM method of QTL mapping that takes into account the causal relationships among traits related to grain yield. Performance of the proposed method is evaluated by simulation study and applied to data from a wheat experiment. Compared with single trait analysis and the multi-trait least-squares analysis, our multi-trait SEM improves statistical power of QTL detection and provides important insight into how QTLs regulate traits by investigating the direct, indirect, and total QTL effects. The approach also helps build biological models that more realistically reflect the complex relationships among QTL and traits and is more precise and efficient in QTL mapping than single trait analysis.

Published
2010
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26. Spectrophotometric assay for ornithine decarboxylase.

Author

Ngo TT, Brillhart KL, Davis RH, Wong RC, Bovaird JH, Digangi JJ, Ristow JL, Marsh JL, Phan AP, and Lenhoff HM

Subjects
Putrescine analysis, Trinitrobenzenesulfonic Acid, Ornithine Decarboxylase analysis, Spectrophotometry methods
Abstract

A rapid and sensitive spectrophotometric assay for ornithine decarboxylase is described. It is based on the observation that the product of ornithine decarboxylase, putrescine, reacts with 2,4,6-trinitrobenzenesulfonic acid to give a colored product soluble in 1-pentanol whereas ornithine does not. The amount of putrescine produced by the enzyme was determined by measuring the absorbance of the 1-pentanol extract of the reaction mixture at 420 nm, and by comparing the results to those obtained by the trapping of 14CO2 and by HPLC assays. The three assays were found to be equivalent in sensitivity, with the spectrophotometric assay having the advantages of being relatively rapid, requiring only common laboratory equipment, and not requiring the use of radioactive isotopes.

Published
1987
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32. Requirement of bound calcium for the action of surface chemoreceptors.

Author

LENHOFF HM and BOVAIRD J

Subjects
Animals, Calcium pharmacology, Chromaffin System, Edetic Acid, Glutathione, Hydra, Invertebrates ethnology, Magnesium
Abstract

The ability of Hydra to carry out the feeding reflex in response to reduced glutathione was inhibited by either (i) standing in distilled water, (ii) the presence of ethylenediamine tetraacetic acid, or (iii) the presence of magnesium ions. These three types of inhibition were reversed instantaneously by the addition of calcium ions.

Published
1959
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