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7 results on '"Bouwman, Mara"'

1. Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration

Author

Nguyen, Phong D., primary, Gooijers, Iris, additional, Campostrini, Giulia, additional, Verkerk, Arie O., additional, Honkoop, Hessel, additional, Bouwman, Mara, additional, de Bakker, Dennis E. M., additional, Koopmans, Tim, additional, Vink, Aryan, additional, Lamers, Gerda E. M., additional, Shakked, Avraham, additional, Mars, Jonas, additional, Mulder, Aat A., additional, Chocron, Sonja, additional, Bartscherer, Kerstin, additional, Tzahor, Eldad, additional, Mummery, Christine L., additional, de Boer, Teun P., additional, Bellin, Milena, additional, and Bakkers, Jeroen, additional

Published
2023
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2. Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration

Author

Nguyen, Phong D, Gooijers, Iris, Campostrini, Giulia, Verkerk, Arie O, Honkoop, Hessel, Bouwman, Mara, de Bakker, Dennis E M, Koopmans, Tim, Vink, Aryan, Lamers, Gerda E M, Shakked, Avraham, Mars, Jonas, Mulder, Aat A, Chocron, Sonja, Bartscherer, Kerstin, Tzahor, Eldad, Mummery, Christine L, de Boer, Teun P, Bellin, Milena, Bakkers, Jeroen, Nguyen, Phong D, Gooijers, Iris, Campostrini, Giulia, Verkerk, Arie O, Honkoop, Hessel, Bouwman, Mara, de Bakker, Dennis E M, Koopmans, Tim, Vink, Aryan, Lamers, Gerda E M, Shakked, Avraham, Mars, Jonas, Mulder, Aat A, Chocron, Sonja, Bartscherer, Kerstin, Tzahor, Eldad, Mummery, Christine L, de Boer, Teun P, Bellin, Milena, and Bakkers, Jeroen

Abstract

Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that control proliferation and redifferentiation to a mature state. We found that the cardiac dyad, a structure that regulates calcium handling and excitation-contraction coupling, played a key role in the redifferentiation process. A component of the cardiac dyad called leucine-rich repeat-containing 10 (Lrrc10) acted as a negative regulator of proliferation, prevented cardiomegaly, and induced redifferentiation. We found that its function was conserved in mammalian cardiomyocytes. This study highlights the importance of the underlying mechanisms required for heart regeneration and their application to the generation of fully functional cardiomyocytes.

Published
2023

3. Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration

Author

Medische Fysiologie, Pathologie Pathologen staf, Circulatory Health, Child Health, Onderzoek, Cardiologie onderzoek 2, Nguyen, Phong D, Gooijers, Iris, Campostrini, Giulia, Verkerk, Arie O, Honkoop, Hessel, Bouwman, Mara, de Bakker, Dennis E M, Koopmans, Tim, Vink, Aryan, Lamers, Gerda E M, Shakked, Avraham, Mars, Jonas, Mulder, Aat A, Chocron, Sonja, Bartscherer, Kerstin, Tzahor, Eldad, Mummery, Christine L, de Boer, Teun P, Bellin, Milena, Bakkers, Jeroen, Medische Fysiologie, Pathologie Pathologen staf, Circulatory Health, Child Health, Onderzoek, Cardiologie onderzoek 2, Nguyen, Phong D, Gooijers, Iris, Campostrini, Giulia, Verkerk, Arie O, Honkoop, Hessel, Bouwman, Mara, de Bakker, Dennis E M, Koopmans, Tim, Vink, Aryan, Lamers, Gerda E M, Shakked, Avraham, Mars, Jonas, Mulder, Aat A, Chocron, Sonja, Bartscherer, Kerstin, Tzahor, Eldad, Mummery, Christine L, de Boer, Teun P, Bellin, Milena, and Bakkers, Jeroen

Published
2023

5. Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration

Author

Cardiologie onderzoek 2, Onderzoek, Child Health, Circulatory Health, de Bakker, Dennis E.M., Bouwman, Mara, Dronkers, Esther, Simões, Filipa C., Riley, Paul R., Goumans, Marie José, Smits, Anke M., Bakkers, Jeroen, Cardiologie onderzoek 2, Onderzoek, Child Health, Circulatory Health, de Bakker, Dennis E.M., Bouwman, Mara, Dronkers, Esther, Simões, Filipa C., Riley, Paul R., Goumans, Marie José, Smits, Anke M., and Bakkers, Jeroen

Published
2021

6. Our mentor Zena Werb (1945–2020)

Author

Abbasi, Aamna J., primary, Abisoye-Ogunniyan, Abisola, additional, Alanizi, Aryn A., additional, Alazzeh, Alaa, additional, Atamaniuc, Elena, additional, Awni, Leena, additional, Berens, Eric B., additional, Bouwman, Mara, additional, Diadhiou, Catherine M.M., additional, Gonzalez, Hugo, additional, Hagerling, Catharina, additional, Hinrichs, Johanna H., additional, Liu, Su-Yang, additional, Metcalf, Kevin J., additional, Nanjaraj, Ankitha, additional, Owyong, Mark, additional, Qureshi, Sameera, additional, Robles, Isabella, additional, Salari, Kiarash, additional, Shamardani, Karin, additional, Verbeek, Tamara, additional, Winkler, Juliane, additional, and Xu, Zhenjie, additional

Published
2020
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