Author: "Bousquet, PJ" - Searchworks@Jio Institute Digital Library Search Results

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206 results on '"Bousquet, PJ"'

1. Access to palliative care for cancer patients between diagnosis and death: a national cohort study

Author: Janah A, Gauthier LR, Morin L, Bousquet PJ, Le Bihan C, Tuppin P, Peretti-Watel P, and Bendiane MK
Subjects: French national health system database, palliative care, cancer, death, factors, timing, Infectious and parasitic diseases, RC109-216
Abstract: Asmaa Janah,1 Lynn R Gauthier,2 Lucas Morin,3 Philippe Jean Bousquet,1,4 Christine Le Bihan,4 Philippe Tuppin,5 Patrick Peretti-Watel,6 Marc-Karim Bendiane11Aix Marseille Univ, INSERM, IRD, Economics and Social Sciences Applied to Health & Analysis of Medical Information (SESSTIM), Marseille, France; 2Department of Family and Emergency Medicine, Faculty of Medicine, Université Laval - Centre Hospitalier Universitaire de Québec-Université Laval Research Centre, Oncology Division and Équipe de recherche Michel-Sarrazin en oncologie psychosociale et soins palliatifs, Université Laval Cancer Research Centre, Québec, Canada; 3Aging Research Center, Karolinska Institutet, Stockholm, Sweden; 4Survey, Monitoring and Assessment Department, Public Health and Healthcare Division, Institut National du Cancer (French National Cancer Institute - INCa), Boulogne Billancourt, France; 5Département des études sur les pathologies et les patients (DEPP), Caisse Nationale d’Assurance Maladie, Paris, France; 6Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, and ORS PACA, Southeastern Health Regional Observatory, Marseille, FranceBackground and purpose: Introducing palliative care earlier in the disease trajectory has been found to provide better management of physical and psychological suffering. In France, the proportion of cancer patients who receive palliative care is unclear. This study aimed primarily to measure the prevalence of access to inpatient palliative care and associated patient-level factors, and to identify the time between access to palliative care and death.Patients and methods: A nationwide retrospective cohort study using data from the French national health system database (SNDS). All those diagnosed with cancer in 2013 who died between 2013 and 2015 were included. Access to inpatient palliative care was the main outcome.Results: Of the 313,059 patients diagnosed with cancer in 2013 in France, 72,315 (23%) died between 2013 and 2015. Overall, 57% had access to inpatient palliative care. The following groups were the most likely to have access to palliative care: women (adjusted odds ratio, aOR: 1.15; 95% CI: 1.11–1.20), people aged 18–49 (aOR: 1.38; 95% CI: 1.26–1.51), individuals with metastatic cancer (aOR: 2.04; 95% CI: 1.96–2.13), and patients with cancer of the nervous system (aOR: 1.80; 95% CI: 1.62–2.01). The median time between palliative care and death was 29 (interquartile range: 13–67) days.Conclusion: More than half of cancer patients who died within 2 years after diagnosis had access to inpatient palliative care. Access to palliative care occurs late in the disease trajectory, often during the final month of life. Further research and guidelines are warranted to optimize access to early, standardized palliative care.Keywords: French national health system database, palliative care, cancer, death, factors, timing
Published: 2019

2. EE590 Duration and Costs of Hypoparathyroidism After Total Thyroidectomy for Thyroid Cancer: A French Nationwide Claims Database Study (1-YEAR FOLLOW-UP)

Author: Bouee Benhamiche, E, primary, Le Bihan Benjamin, C, additional, Bousquet, PJ, additional, and Benmiloud, F, additional
Published: 2022
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3. CO12 Prevalence and Factors Associated With Hypoparathyroidism After Total Thyroidectomy for Thyroid Cancer: A French Nationwide Claims Database Study

Author: Bouee Benhamiche, E, primary, Le Bihan Benjamin, C, additional, Bousquet, PJ, additional, and Benmiloud, F, additional
Published: 2022
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4. Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis – A EUFOREA‐ARIA‐EPOS‐AIRWAYS ICP statement

Author: Hellings, P. W., Fokkens, W. J., Bachert, C., Akdis, C. A., Bieber, T., Agache, I., Bernal‐Sprekelsen, M., Canonica, G. W., Gevaert, P., Joos, G., Lund, V., Muraro, A., Onerci, M., Zuberbier, T., Pugin, B., Seys, S. F., Bousquet, J., Aberer, W, Agache, I, Akdis, CA, Akdis, M, Alobid, I, Ankri, J, Annesi‐Maesano, I, Ansotegui, IJ, Anto, JM, Arnavielhe, S, Arshad, H, Asarnoj, A, Avolio, F, Bachert, C, Bachert, C, Baiardini, I, Barbagallo, M, Barbara, C, Baroody, F, Bateman, ED, Bedbrook, A, Beghé, B, Bel, EH, Bennoor, KS, Benson, M, Bergmann, KC, Bewick, M, Bialoszewski, AZ, Bieber, T, Bindslev‐Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, AL, Bonini, M, Bonini, S, Bosnic‐Anticevich, S, Bosse, I, Bouchard, J, Boulet, LP, Bourret, R, Bousquet, J, Bousquet, PJ, Braido, F, Briggs, AH, Brightling, CE, Brozek, J, Bucca, C, Buhl, R, Bunu, C, Burte, E, Bush, A, Caballero‐Fonseca, F, Caimmi, DP, Calderon, MA, Camargos, PA, Camuzat, T, Canonica, GW, Cardona, V, Carlsen, KH, Carr, W, Carreiro‐Martins, P, Carriazo, AM, Casale, T, Cepeda Sarabia, AM, Cervin, A, Cesari, M, Chatzi, L, Chavannes, NH, Chiron, R, Chivato, T, Chkhartishvili, E, Chuchalin, AG, Chung, KF, Ciprandi, G, Cohen, N, Conzález Diaz, S, Cox, L, Crooks, G, Cruz, AA, Custovic, A, Dahl, R, Dahlen, SE, Darsow, U, De Carlo, G, De Manuel Keenoy, E, de Sousa, JC, De Vries, G, Dedeu, T, Deleanu, D, Demoly, P, Denburg, JA, Devillier, P, Didier, A, Dinh‐Xuan, AT, Dokic, D, Douagui, H, Douglas, R, Dray, G, Du Toit, G, Dubakiene, R, Durham, SR, Dykewicz, MS, Eklund, P, El‐Gamal, Y, Ellers, E, Emuzyte, R, Farrell, J, Fink Wagner, A, Fiocchi, A, Fletcher, M, Fokkens, WJ, Fonseca, J, Forastiere, F, Gaga, M, Gamkrelidze, A, Gemicioğlu, B, Georgalas, C, Gereda, JE, Gevaert, P, Goossens, H, Grisle, I, Guldemond, NA, Gutter, Z, Guzmán, MA, Haahtela, T, Harvey, R, Heinrich, J, Hellings, PW, Hellings, PW, Hellquist‐Dahl, B, Hopkins, C, Horak, F, Hourihane, JO, Humbert, M, Hyland, M, Iaccarino, G, Illario, M, Jares, EJ, Jeandel, C, Johnston, SL, Jonquet, O, Joos, G, Joos, G, Jung, KS, Just, J, Jutel, M, Kaidashev, I, Kalayci, O, Kalogjera, L, Kalyoncu, AF, Kardas, P, Keil, T, Keith, PK, Kerkhof, M, Kern, B, Kerstjens, HA, Khaitov, M, Khaltaev, N, Klimek, L, Kogevinas, M, Kolek, V, Koppelman, GH, Kowalski, M, Kowalski, ML, Kuitunen, M, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Larenas‐Linnemann, D, Lau, S, Laune, D, Le, LT, Li, J, Lieberman, P, Lipworth, B, Lodrup Carlsen, KC, Louis, R, Lund, VJ, Lupinek, C, MacNee, W, Magar, Y, Magnan, A, Mahboub, B, Maier, D, Majer, I, Malva, J, Manning, P, Marshall, GD, Masjedi, MR, Mathieu‐Dupas, E, Maurer, M, Mavale‐Manuel, S, Melén, E, Melo‐Gomes, E, Meltzer, EO, Mercier, J, Merk, H, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot‐Keurinck, J, Mohammad, Y, Momas, I, Morais‐Almeida, M, Mösges, R, Mullol, J, Mullol, J, Muraro, A, Murray, R, Naclerio, R, Nadif, R, Namazova‐Baranova, L, Neffen, H, Nekam, K, Nieto, A, Niggemann, B, Nogueira‐Silva, L, Nogues, M, Nyembue, TD, OʼHehir, RE, Ohta, K, Okamoto, Y, Okubo, K, Olive‐Elias, M, Ouedraogo, S, Paggiaro, P, Pali‐Schöll, I, Palkonen, S, Panzner, P, Papadopoulos, NG, Papi, A, Park, HS, Passalacqua, G, Pawankar, R, Pedersen, S, Pereira, AM, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Pohl, W, Popov, TA, Portejoie, F, Postma, D, Potter, P, Poulsen, LK, Price, D, Price, D, Rabe, KF, Raciborski, F, Riechelmann, H, Robalo‐Cordeiro, C, Roberts, G, Rodenas, F, Rodriguez‐Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado‐Pinto, J, Rosario, N, Rottem, M, Ryan, D, Samolinski, B, Sanchez‐Borges, M, Sastre‐Dominguez, J, Scadding, GK, Schlosser, R, Schmid‐Grendelmeier, P, Schunemann, HJ, Scichilone, N, Senior, B, Serrano, E, Sheikh, A, Shields, M, Simons, FER, Siroux, V, Sisul, JC, Skrindo, I, Smit, HA, Solé, D, Sooronbaev, T, Spranger, O, Stellato, C, Stelmach, R, Sterk, PJ, Strandberg, T, Sunyer, J, Thijs, C, Thomas, M, Todo‐Bom, A, Tomazic, PV, Toskala, E, Triggiani, M, Valenta, R, Valero, A, Valiulis, A, Valovirta, E, van Eerd, M, van Ganse, E, van Hage, M, van Wick, RG, Vandenplas, O, Varona, LL, Vazankari, T, Vellas, B, Ventura, MT, Vezzani, G, Viegi, G, Voegels, R, Vontetsianos, T, Wagenmann, M, Wahn, U, Walker, S, Wang, DY, Wang, Y, Werfel, T, Whalley, B, Wickman, M, Williams, DM, Williams, S, Wilson, N, Wormald, PJ, Wright, J, Yawn, BP, Yiallouros, PK, Yorgancioglu, A, Young, I, Yusuf, OM, Zaidi, A, Zar, HJ, Zernotti, ME, Zhang, L, Zhong, N, Zidarn, M, and Zuberbier, T
Published: 2017
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5. Correlation between work impairment, scores of rhinitis severity and asthma using the MASK-air ® App

Author: Bédard, Annabelle, Antó, Josep, Fonseca, Joao, Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia, Cardona, Victoria, Cruz, Alvaro, Fokkens, Wytske, Garcia-Aymerich, Judith, Hellings, Peter, Ivancevich, Juan, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Désirée, Melen, Erik, Monti, Ricardo, Mösges, Ralf, Mullol, Joaquim, Papadopoulos, Nikos, Pham-Thi, Nhan, Samolinski, Boleslaw, V Tomazic, Peter, Toppila-Salmi, Sanna, Ventura, Maria Teresa, Yorgancioglu, Arzu, Bousquet, Jean, Pfaar, Oliver, Basagana, Xavier, Bosnic‐Anticevich, Sinthia, Pham‐Thi, Nhân, Hellings, PW, Aberer, W., Agache, I., Akdis, Ca, Akdis, M., Aliberti, MR, Almeida, R., Amat, F., Angles, R, Annesi‐Maesano, I, Ansotegui, IJ, Anto, JM, Arnavielle, S, Asayag, E, Asarnoj, A, Arshad, H, Avolio, F, Bacci, E, Baiardini, I, Barbara, C, Barbagallo, M., Baroni, I, Barreto, BA, Basagaña, X., Bateman, ED, Bedolla‐Barajas, M, Bewick, M., Beghé, B., Bel, EH, Bergmann, KC, Bennoor, KS, Benson, M, Bertorello, L, Białoszewski, AZ, Bieber, T., Bialek, S, Bindslev‐Jensen, Carsten, Bjermer, L., Blain, H., Blasi, F., Blua, A, Bochenska Marciniak, M, Bogus‐Buczynska, I, Boner, AL, Bonini, M., Bonini, S., Bosnic‐Anticevich, CS, Bosse, I., Bouchard, J., Boulet, LP, Bourret, R., Bousquet, Pj, Braido, F, Briedis, V, Brightling, CE, Brozek, J, Bucca, C, Buhl, R, Buonaiuto, R, Panaitescu, C, Burguete Cabañas, MT, Burte, E., Bush, A, Caballero‐Fonseca, F, Caillaud, D., Caimmi, D., Calderon, MA, Camargos, PAM, Camuzat, T., Canfora, G, Canonica, Gw, Carlsen, KH, Carreiro‐Martins, P, Carriazo, AM, Carr, W, Cartier, C., Casale, T., Castellano, G, Cecchi, L, Cepeda, AM, Chavannes, NH, Chen, Y., Chiron, R., Chivato, T, Chkhartishvili, E, Chuchalin, AG, Chung, KF, Ciaravolo, MM, Ciceran, A, Cingi, C, Ciprandi, G, Carvalho Coehlo, AC, Colas, L, Colgan, E, Coll, J, Conforti, D, Constantinidis, J, de Sousa, J Correia, Cortés‐Grimaldo, RM, Corti, F, Costa, E, Costa‐Dominguez, MC, Courbis, AL, Cox, L, Crescenzo, M, Cruz, AA, Custovic, A., Czarlewski, W., Dahlen, Se, D’Amato, G, Dario, C, Da Silva, J., Dauvilliers, Y., Darsow, U, De Blay, F., De Carlo, G, Dedeu, T, de Fátima Emerson, M, De Feo, G., De Vries, G, De Martino, B, Motta Rubini, NP, Deleanu, D, Denburg, JA, devillier, P., Di Capua Ercolano, S, Di Carluccio, N, Didier, A., Dokic, D, Dominguez‐Silva, MG, Douagui, H, Dray, G., Dubakiene, R, Durham, Sr, Du Toit, G, Dykewicz, MS, El‐Gamal, Y, Eklund, P, Eller, E, Emuzyte, R., Farrell, J, Farsi, A, de Mello, J Ferreira, Ferrero, J, Fink‐Wagner, A, Fiocchi, A, Fokkens, WJ, Fonseca, JA, Fontaine, Jf, Forti, S, Fuentes‐Perez, JM, Gálvez‐Romero, JL, Gamkrelidze, A, Garcia‐Aymerich, Judith, García‐Cobas, CY, Garcia‐Cruz, MH, Gemicioğlu, B, Genova, S, Christoff, G, Gereda, JE, Van Wijk, R Gerth, Gomez, RM, Gómez‐Vera, J, González Diaz, S, Gotua, M., Grisle, I, Guidacci, M, Guldemond, NA, Gutter, Z, Guzmán, MA, Haahtela, T., Hajjam, J, Hernández, L, Hourihane, JO’B, Huerta‐Villalobos, YR, Humbert, M., Iaccarino, G., Illario, M, Ispayeva, Z, Ivancevich, JC, Jares, EJ, Jassem, E, Johnston, Sl, Joos, G, Jung, KS, Just, J., Jutel, M, Kaidashev, I, Kalayci, O, Kalyoncu, AF, Karjalainen, J, Kardas, P, Keil, T, Keith, PK, Khaitov, M, Khaltaev, N, Kleine‐Tebbe, J, Kowalski, Ml, Kuitunen, M, Kull, I., Kupczyk, M, Krzych‐Fałta, E, Lacwik, P, Larenas‐Linnemann, Désirée, Laune, D., Lauri, D, Lavrut, J, Le, LTT, Lessa, M, Levato, G, Li, J., Lieberman, P, Lipiec, A, Lipworth, B, Lodrup Carlsen, KC, Louis, R, Lourenço, O, Luna‐Pech, JA, Magnan, A., Mahboub, B, Maier, D., Mair, A, Majer, I, Malva, J, Mandajieva, E, Manning, P, De Manuel Keenoy, E, Marshall, GD, Masjedi, MR, Maspero, JF, Mathieu‐Dupas, E, Matta Campos, JJ, Matos, AL, Maurer, M, Mavale‐Manuel, S, Mayora, O, Meco, C, Medina‐Avalos, MA, Melo‐Gomes, E, Meltzer, EO, Menditto, E., Miculinic, N, Mihaltan, F., Milenkovic, B, Moda, G, Mogica‐Martinez, MD, Mohammad, Y, Momas, I., Montefort, S, Mora Bogado, D, Morais‐Almeida, M, Morato‐Castro, FF, Mota‐Pinto, A, Moura Santo, P, Münter, L, Muraro, A, Murray, R, Naclerio, R., Nadif, R., Nalin, M, Napoli, L, Namazova‐Baranova, L, Neffen, H, Niedeberger, V, Nekam, K, Neou, A, Nieto, A, Nogueira‐Silva, L, Nogues, M., Novellino, E, Nyembue, TD, O’Hehir, RE, Odzhakova, C, Ohta, K., Okamoto, Y., Okubo, K, Onorato, GL, Ortega Cisneros, M, Ouédraogo, S., Pali‐Schöll, I, Palkonen, S, Panzner, P, Papadopoulos, NG, Park, HS, Papi, A., Passalacqua, G, Paulino, E, Pawankar, R, Pedersen, S, Pépin, JL, Pereira, AM, Persico, M, PHILLIPS, J, Picard, R., Pigearias, B, Pin, I., Pitsios, C., Plavec, D, Pohl, W, Popov, TA, Portejoie, F., Potter, P, Pozzi, AC, Price, D, Prokopakis, EP, Puy, R, Pugin, B, Pulido Ross, RE, Przemecka, M, Rabe, KF, Raciborski, F, Rajabian‐Soderlund, R, Reitsma, S, Ribeirinho, I, Rimmer, J, Rivero‐Yeverino, D, Rizzo, JA, Rizzo, MC, Robalo‐Cordeiro, C, Rodenas, F, Rodo, X, Rodriguez Gonzalez, M, Rodriguez‐Mañas, L, Rolland, C, Rodrigues Valle, S, Roman Rodriguez, M., Romano, A, Rodriguez‐Zagal, E, Rolla, G, Roller‐Wirnsberger, RE, Romano, M, Rosado‐Pinto, J, Rosario, N., Rottem, M, Ryan, D, Sagara, H, Salimäki, J, Sanchez‐Borges, M, Sastre‐Dominguez, J, Scadding, GK, Schunemann, HJ, Scichilone, N, Schmid‐Grendelmeier, P, Sarquis Serpa, F, Shamai, S., Sheikh, A., Sierra, M, Simons, FER, Siroux, V., Sisul, JC, Skrindo, I, Solé, D, Somekh, D, Sondermann, M, Sooronbaev, T, Sova, M, Sorensen, M, Sorlini, M, Spranger, O, Stellato, C, Stelmach, R, Stukas, R, Sunyer, J., Strozek, J, Szylling, A, Tebyriçá, JN, Thibaudon, M., To, T., Todo‐Bom, A, Tomazic, PV, Toppila‐Salmi, Sanna, Trama, U, Triggiani, M, Suppli Ulrik, C, Urrutia‐Pereira, M, Valenta, R, Valero, A., Valiulis, A., Valovirta, E., van Eerd, M, Van Ganse, E., van Hage, M, Vandenplas, O, Ventura, MT, Vezzani, G, Vasankari, T, Vatrella, A., Verissimo, MT, Viart, F., Viegi, G., Vicheva, D, Vontetsianos, T, Wagenmann, M, Walker, S, Wallace, D, Wang, DY, Waserman, S., Werfel, T, Westman, M, Wickman, M., Williams, DM, Williams, S, Wilson, N, Wright, J, Wroczynski, P, Yakovliev, P, Yawn, BP, Yiallouros, PK, Yusuf, OM, Zar, HJ, Zhang, L., Zhong, N, Zernotti, ME, Zhanat, I, Zidarn, M, Zuberbier, T., Zubrinich, C, Zurkuhlen, A, Mercier, Jacques, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), IMIM-Hospital del Mar, Generalitat de Catalunya, Center of Research in Health Technologies and Information Systems (CINTESIS), Universidade do Porto = University of Porto, KYomed INNOV, Ghent University Hospital, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Odense University Hospital [Odense, Denmark], Woolcock Institute of Medical Research [Sydney], The University of Sydney, Vall d'Hebron University Hospital [Barcelona], ProAR - FMB, Federal University of Bahia School of Medicine, European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), University Hospitals Leuven [Leuven], Zentrum für Rhinologie und Allergologie [Wiesbaden, Germany], Division of Internal Medicine, Asthma and Allergy, Medical University of Łódź (MUL)-Barlicki University Hospital, Vilnius University [Vilnius], Clínica de Alergia- Asma y Pediatría, Hospital Medica Sur, Institute of Environmental Medicine, Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm]-Astrid Lindgren Children's Hospital, Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Service de Pneumologie Allergologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur [Paris] (IP), Medical University of Warsaw - Poland, Department of Pulmonology, Manisa Celal Bayar University, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Center for Rhinology and Allergology Wiesbaden, University Hospital Mannheim, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Department of Allergy and Clinical Immunology, Faculty of Medicine-Transylvania University, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Department Engineering Quimica (ICEMS), Aix Marseille Université (AMU), Istituto Nazionale di Fisica Nucleare, sezione di Bari (INFN, sezione di Bari), Istituto Nazionale di Fisica Nucleare (INFN), iQ4U consultants Ltd, Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton-School of Medicine, Department of Respiratory Medicine and Allergy, Department of Pathophysiology and Transplantation, Università degli Studi di Milano = University of Milan (UNIMI), Istituto di Geoscienze e Georisorse, Pavia, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, CHU Montpellier, Laboratoire National Henri Becquerel (LNHB), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Département d'instrumentation Numérique (DIN (CEA-LIST)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire de recherche sur les mécanismes moléculaires et pharmacologiques de l’obstruction bronchique (LOBIP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Région Languedoc-Roussillon-Midi-Pyrénées, University of South Florida [Tampa] (USF), Chinese academy of sciences Sanya, Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier] (CRCM [Montpellier]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Service des Maladies Respiratoires, Laboratoire de Génie Informatique et d'Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Department of Paediatrics, UCB Pharma, Colombes, CHU Strasbourg, Università degli Studi di Salerno = University of Salerno (UNISA), Hôpital Foch [Suresnes], Service de pneumologie [Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Informatique, Image, Intelligence Artificielle (I3A), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-IMT - MINES ALES (IMT - MINES ALES), Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Center for Allergy and Immunology Research [Tbilisi], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Center for Turbulence Research [Stanford] (CTR), Stanford University, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (SysDiag ), BIO-RAD-Centre National de la Recherche Scientifique (CNRS), Équipe de Recherche en Textes, Informatique, Multilinguisme (ERTIM), Institut National des Langues et Civilisations Orientales (Inalco), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Biomax Informatics AG, 'Federico II' University of Naples Medical School, Pneumology Department, Marius Nasta Institute of Pneumology, Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Johns Hopkins University School of Medicine [Baltimore], CARSAT-LR, Montpellier, Dept. of Electronic Engineering, Chubu University, Institute for Solid State Physics, The University of Tokyo (UTokyo), Respiratory Medicine, Laboratoire de physique et chimie des nano-objets (LPCNO), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), CHU Grenoble, University of Cyprus [Nicosia] (UCY), Son Pisa Primary Care Centre, IB-Salut Balearic Health Service, Department of Computer Science [Haifa], University of Haifa [Haifa], University of Edinburgh, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Réseau National de Surveillance Aérobiologique (RNSA), CIRCE, Ctr Res Energy Resources & Consumpt, Zaragoza 50018, Spain, University of Turku, Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), ASA (Advanced Solution Accelerator) (Data management : Développement Back-Office, hébergement…), 34830 Jacou, Consiglio nazionale delle ricerche, Instituto di fisiologia clinica, McMaster University [Hamilton, Ontario], Department of Molecular Medicine and Surgery, UMR CNRS 8179, Université de Lille, Sciences et Technologies-Centre National de la Recherche Scientifique (CNRS), University Hospital of Cologne [Cologne], Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), ISGlobal, Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, IMIM (Hospital del Mar Research Institute), Barcelona, Spain, CINTESIS, Center for Research in Health Technology and Information Systems, Faculdade de Medicina da Universidade do Porto, Porto, Portugal, Medida, Lda Porto, Porto, Portugal, KYomed INNOV, Montpellier, France, Upper Airways Research Laboratory, ENT Dept, Ghent University Hospital, Ghent, Belgium, MACVIA-France, Montpellier, France, Department of Dermatology and Allergy Centre, Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark, Woolcock Institute of Medical Research, University of Sydney and Woolcock Emphysema Centre and Sydney Local Health District, Glebe, NSW, Australia, Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL Research Network, Barcelona, Spain, ProAR – Nucleo de Excelencia em Asma, Federal University of Bahia, Brasil and WHO GARD Planning Group, Salvador, Brazil, Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, Netherlands, Euforea, Brussels, Belgium, Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina, Center for Rhinology and Allergology, Wiesbaden, Germany, Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland, Department of Pathology, Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, Vilnius, Lithuania, Clinic of Chest diseases and Allergology, Faculty of Medicine, Institute of Clinical Medicine, Vilnius, Lithuania, Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico, Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Allergy and Clinical Immunology Unit, Department of Medical Sciences, University of Torino & Mauriziano Hospital, Torino, Italy, Institute of Medical Statistics, and Computational Biology, Medical Faculty, University of Cologne, Cologne, Germany, CRI-Clinical Research International-Ltd, Hamburg, Germany, Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, University of Barcelona, Barcelona, Spain, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain, Division of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of Manchester, Manchester, United Kingdom, Allergy Department, Pasteur Institute, Paris, France, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland, Department of General ORL, H&NS, Medical University of Graz, Graz, Austria, Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland, Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy, Department of Pulmonary Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey, University Hospital, Montpellier, France, INSERM U 1168, VIMA: Ageing and Chronic Diseases Epidemiological and Public Health Approaches, Villejuif, France, UMR-S 1168, Université Versailles St-Quentin-en-Yvelines, Versailles, France, Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany, Comprehensive Allergy Center, Department of Dermatology and Allergy, Berlin Institute of Health, Berlin, Germany, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Phillipps-Universität, Marburg, Germany, Universidade do Porto, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut Pasteur [Paris], University of Milan, University of Naples Federico II-CNR, Rome, Italy and Department of Medicine, Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Università degli Studi di Salerno (UNISA), CHU Toulouse [Toulouse]-Hôpital Larrey [Toulouse], CHU Toulouse [Toulouse], Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Arts et Métiers (ENSAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, University of Helsinki, Service d'Allergologie pédiatrique [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Cyprus [Nicosia], Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Bedard, A., Anto, J. M., Fonseca, J. A., Arnavielhe, S., Bachert, C., Bedbrook, A., Bindslev-Jensen, C., Bosnic-Anticevich, S., Cardona, V., Cruz, A. A., Fokkens, W. J., Garcia-Aymerich, J., Hellings, P. W., Ivancevich, J. C., Klimek, L., Kuna, P., Kvedariene, V., Larenas-Linnemann, D., Melen, E., Monti, R., Mosges, R., Mullol, J., Papadopoulos, N. G., Pham-Thi, N., Samolinski, B., Tomazic, P. V., Toppila-Salmi, S., Ventura, M. T., Yorgancioglu, A., Bousquet, J., Pfaar, O., Basagana, X., Aberer, W., Agache, I., Akdis, C. A., Akdis, M., Aliberti, M. R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I. J., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Bateman, E. D., Bedolla-Barajas, M., Bewick, M., Beghe, B., Bel, E. H., Bergmann, K. C., Bennoor, K. S., Benson, M., Bertorello, L., Bialoszewski, A. Z., Bieber, T., Bialek, S., Bjermer, L., Blain, H., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A. L., Bonini, M., Bonini, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briedis, V., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Burguete Cabanas, M. T., Burte, E., Bush, A., Caballero-Fonseca, F., Caillaud, D., Caimmi, D., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Canfora, G., Canonica, G. W., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda, A. M., Chavannes, N. H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Carvalho Coehlo, A. C., Colas, L., Colgan, E., Coll, J., Conforti, D., Constantinidis, J., Correia de Sousa, J., Cortes-Grimaldo, R. M., Corti, F., Costa, E., Costa-Dominguez, M. C., Courbis, A. L., Cox, L., Crescenzo, M., Custovic, A., Czarlewski, W., Dahlen, S. E., D'Amato, G., Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., de Fatima Emerson, M., De Feo, G., De Vries, G., De Martino, B., Motta Rubini, N. P., Deleanu, D., Denburg, J. A., Devillier, P., Di Capua Ercolano, S., Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M. G., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., El-Gamal, Y., Eklund, P., Eller, E., Emuzyte, R., Farrell, J., Farsi, A., Ferreira de Mello, J., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fontaine, J. F., Forti, S., Fuentes-Perez, J. M., Galvez-Romero, J. L., Gamkrelidze, A., Garcia-Cobas, C. Y., Garcia-Cruz, M. H., Gemicioglu, B., Genova, S., Christoff, G., Gereda, J. E., Gerth van Wijk, R., Gomez, R. M., Gomez-Vera, J., Gonzalez Diaz, S., Gotua, M., Grisle, I., Guidacci, M., Guldemond, N. A., Gutter, Z., Guzman, M. A., Haahtela, T., Hajjam, J., Hernandez, L., Hourihane, J. O. '. B., Huerta-Villalobos, Y. R., Humbert, M., Iaccarino, G., Illario, M., Ispayeva, Z., Jares, E. J., Jassem, E., Johnston, S. L., Joos, G., Jung, K. S., Just, J., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Kowalski, M. L., Kuitunen, M., Kull, I., Kupczyk, M., Krzych-Falta, E., Lacwik, P., Laune, D., Lauri, D., Lavrut, J., Le, L. T. T., Lessa, M., Levato, G., Li, J., Lieberman, P., Lipiec, A., Lipworth, B., Lodrup Carlsen, K. C., Louis, R., Lourenco, O., Luna-Pech, J. A., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maspero, J. F., Mathieu-Dupas, E., Matta Campos, J. J., Matos, A. L., Maurer, M., Mavale-Manuel, S., Mayora, O., Meco, C., Medina-Avalos, M. A., Melo-Gomes, E., Meltzer, E. O., Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. D., Mohammad, Y., Momas, I., Montefort, S., Mora Bogado, D., Morais-Almeida, M., Morato-Castro, F. F., Mota-Pinto, A., Moura Santo, P., Munter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T. D., O'Hehir, R. E., Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G. L., Ortega Cisneros, M., Ouedraogo, S., Pali-Scholl, I., Palkonen, S., Panzner, P., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pepin, J. L., Pereira, A. M., Persico, M., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Pozzi, A. C., Price, D., Prokopakis, E. P., Puy, R., Pugin, B., Pulido Ross, R. E., Przemecka, M., Rabe, K. F., Raciborski, F., Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rivero-Yeverino, D., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Rodriguez Gonzalez, M., Rodriguez-Manas, L., Rolland, C., Rodrigues Valle, S., Roman Rodriguez, M., Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R. E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimaki, J., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schunemann, H. J., Scichilone, N., Schmid-Grendelmeier, P., Sarquis Serpa, F., Shamai, S., Sheikh, A., Sierra, M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Sole, D., Somekh, D., Sondermann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyrica, J. N., Thibaudon, M., To, T., Todo-Bom, A., Trama, U., Triggiani, M., Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hage, M., Vandenplas, O., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, G., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zernotti, M. E., Zhanat, I., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, Universidade do Porto [Porto], Kyomed, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Universitat Pompeu Fabra [Barcelona], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Service des Maladies Respiratoires, Hôpital Arnaud de Villeneuve-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Dermatology [Graz, Austria], Medical University Graz, University of Zürich [Zürich] (UZH), National Institute for Nuclear Physics (INFN), Institut Jean Lamour (IJL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Clermont Université-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Recherche Agronomique (INRA), University of South Florida (USF), University of Salerno (UNISA), CHU Toulouse [Toulouse]-Hôpital Larrey, Institut Mines-Télécom [Paris] (IMT), Center for Turbulence Research (CTR), Stanford University [Stanford], Service d'allergologie [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Trousseau [APHP], Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), The University of Tokyo, Sondra, CentraleSupélec, Université Paris-Saclay (SONDRA), ONERA-CentraleSupélec-Université Paris-Saclay, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), RNSA, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Ear, Nose and Throat, AII - Inflammatory diseases, Pulmonology, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bedard A., Anto J.M., Fonseca J.A., Arnavielhe S., Bachert C., Bedbrook A., Bindslev-Jensen C., Bosnic-Anticevich S., Cardona V., Cruz A.A., Fokkens W.J., Garcia-Aymerich J., Hellings P.W., Ivancevich J.C., Klimek L., Kuna P., Kvedariene V., Larenas-Linnemann D., Melen E., Monti R., Mosges R., Mullol J., Papadopoulos N.G., Pham-Thi N., Samolinski B., Tomazic P.V., Toppila-Salmi S., Ventura M.T., Yorgancioglu A., Bousquet J., Pfaar O., Basagana X., Aberer W., Agache I., Akdis C.A., Akdis M., Aliberti M.R., Almeida R., Amat F., Angles R., Annesi-Maesano I., Ansotegui I.J., Arnavielle S., Asayag E., Asarnoj A., Arshad H., Avolio F., Bacci E., Baiardini I., Barbara C., Barbagallo M., Baroni I., Barreto B.A., Bateman E.D., Bedolla-Barajas M., Bewick M., Beghe B., Bel E.H., Bergmann K.C., Bennoor K.S., Benson M., Bertorello L., Bialoszewski A.Z., Bieber T., Bialek S., Bjermer L., Blain H., Blasi F., Blua A., Bochenska Marciniak M., Bogus-Buczynska I., Boner A.L., Bonini M., Bonini S., Bosse I., Bouchard J., Boulet L.P., Bourret R., Bousquet P.J., Braido F., Briedis V., Brightling C.E., Brozek J., Bucca C., Buhl R., Buonaiuto R., Panaitescu C., Burguete Cabanas M.T., Burte E., Bush A., Caballero-Fonseca F., Caillaud D., Caimmi D., Calderon M.A., Camargos P.A.M., Camuzat T., Canfora G., Canonica G.W., Carlsen K.H., Carreiro-Martins P., Carriazo A.M., Carr W., Cartier C., Casale T., Castellano G., Cecchi L., Cepeda A.M., Chavannes N.H., Chen Y., Chiron R., Chivato T., Chkhartishvili E., Chuchalin A.G., Chung K.F., Ciaravolo M.M., Ciceran A., Cingi C., Ciprandi G., Carvalho Coehlo A.C., Colas L., Colgan E., Coll J., Conforti D., Constantinidis J., Correia de Sousa J., Cortes-Grimaldo R.M., Corti F., Costa E., Costa-Dominguez M.C., Courbis A.L., Cox L., Crescenzo M., Custovic A., Czarlewski W., Dahlen S.E., D'Amato G., Dario C., da Silva J., Dauvilliers Y., Darsow U., De Blay F., De Carlo G., Dedeu T., de Fatima Emerson M., De Feo G., De Vries G., De Martino B., Motta Rubini N.P., Deleanu D., Denburg J.A., Devillier P., Di Capua Ercolano S., Di Carluccio N., Didier A., Dokic D., Dominguez-Silva M.G., Douagui H., Dray G., Dubakiene R., Durham S.R., Du Toit G., Dykewicz M.S., El-Gamal Y., Eklund P., Eller E., Emuzyte R., Farrell J., Farsi A., Ferreira de Mello J., Ferrero J., Fink-Wagner A., Fiocchi A., Fontaine J.F., Forti S., Fuentes-Perez J.M., Galvez-Romero J.L., Gamkrelidze A., Garcia-Cobas C.Y., Garcia-Cruz M.H., Gemicioglu B., Genova S., Christoff G., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gomez-Vera J., Gonzalez Diaz S., Gotua M., Grisle I., Guidacci M., Guldemond N.A., Gutter Z., Guzman M.A., Haahtela T., Hajjam J., Hernandez L., Hourihane J.O.'.B., Huerta-Villalobos Y.R., Humbert M., Iaccarino G., Illario M., Ispayeva Z., Jares E.J., Jassem E., Johnston S.L., Joos G., Jung K.S., Just J., Jutel M., Kaidashev I., Kalayci O., Kalyoncu A.F., Karjalainen J., Kardas P., Keil T., Keith P.K., Khaitov M., Khaltaev N., Kleine-Tebbe J., Kowalski M.L., Kuitunen M., Kull I., Kupczyk M., Krzych-Falta E., Lacwik P., Laune D., Lauri D., Lavrut J., Le L.T.T., Lessa M., Levato G., Li J., Lieberman P., Lipiec A., Lipworth B., Lodrup Carlsen K.C., Louis R., Lourenco O., Luna-Pech J.A., Magnan A., Mahboub B., Maier D., Mair A., Majer I., Malva J., Mandajieva E., Manning P., De Manuel Keenoy E., Marshall G.D., Masjedi M.R., Maspero J.F., Mathieu-Dupas E., Matta Campos J.J., Matos A.L., Maurer M., Mavale-Manuel S., Mayora O., Meco C., Medina-Avalos M.A., Melo-Gomes E., Meltzer E.O., Menditto E., Mercier J., Miculinic N., Mihaltan F., Milenkovic B., Moda G., Mogica-Martinez M.D., Mohammad Y., Momas I., Montefort S., Mora Bogado D., Morais-Almeida M., Morato-Castro F.F., Mota-Pinto A., Moura Santo P., Munter L., Muraro A., Murray R., Naclerio R., Nadif R., Nalin M., Napoli L., Namazova-Baranova L., Neffen H., Niedeberger V., Nekam K., Neou A., Nieto A., Nogueira-Silva L., Nogues M., Novellino E., Nyembue T.D., O'Hehir R.E., Odzhakova C., Ohta K., Okamoto Y., Okubo K., Onorato G.L., Ortega Cisneros M., Ouedraogo S., Pali-Scholl I., Palkonen S., Panzner P., Park H.S., Papi A., Passalacqua G., Paulino E., Pawankar R., Pedersen S., Pepin J.L., Pereira A.M., Persico M., Phillips J., Picard R., Pigearias B., Pin I., Pitsios C., Plavec D., Pohl W., Popov T.A., Portejoie F., Potter P., Pozzi A.C., Price D., Prokopakis E.P., Puy R., Pugin B., Pulido Ross R.E., Przemecka M., Rabe K.F., Raciborski F., Rajabian-Soderlund R., Reitsma S., Ribeirinho I., Rimmer J., Rivero-Yeverino D., Rizzo J.A., Rizzo M.C., Robalo-Cordeiro C., Rodenas F., Rodo X., Rodriguez Gonzalez M., Rodriguez-Manas L., Rolland C., Rodrigues Valle S., Roman Rodriguez M., Romano A., Rodriguez-Zagal E., Rolla G., Roller-Wirnsberger R.E., Romano M., Rosado-Pinto J., Rosario N., Rottem M., Ryan D., Sagara H., Salimaki J., Sanchez-Borges M., Sastre-Dominguez J., Scadding G.K., Schunemann H.J., Scichilone N., Schmid-Grendelmeier P., Sarquis Serpa F., Shamai S., Sheikh A., Sierra M., Simons F.E.R., Siroux V., Sisul J.C., Skrindo I., Sole D., Somekh D., Sondermann M., Sooronbaev T., Sova M., Sorensen M., Sorlini M., Spranger O., Stellato C., Stelmach R., Stukas R., Sunyer J., Strozek J., Szylling A., Tebyrica J.N., Thibaudon M., To T., Todo-Bom A., Trama U., Triggiani M., Suppli Ulrik C., Urrutia-Pereira M., Valenta R., Valero A., Valiulis A., Valovirta E., van Eerd M., van Ganse E., van Hage M., Vandenplas O., Vezzani G., Vasankari T., Vatrella A., Verissimo M.T., Viart F., Viegi G., Vicheva D., Vontetsianos T., Wagenmann M., Walker S., Wallace D., Wang D.Y., Waserman S., Werfel T., Westman M., Wickman M., Williams D.M., Williams S., Wilson N., Wright J., Wroczynski P., Yakovliev P., Yawn B.P., Yiallouros P.K., Yusuf O.M., Zar H.J., Zhang L., Zhong N., Zernotti M.E., Zhanat I., Zidarn M., Zuberbier T., Zubrinich C., and Zurkuhlen A.
Subjects: 0301 basic medicine, SYMPTOMS, Smart phone, Allergy, Escala visual analógica, INNOVATION, [SDV]Life Sciences [q-bio], Medical and Health Sciences, Correlation, visual analogue scale, 0302 clinical medicine, Quality of life, Visual analogue scale, QUALITY-OF-LIFE, Màscares, Immunology and Allergy, score, Nose, Rinitis, Rhinitis, PRODUCTIVITY COSTS, asthma, MASK, rhinitis, Score, Explained variation, Response Variability, Mobile Applications, ALLERGIC RHINITIS, rhiniti, medicine.anatomical_structure, TRIALS, Rinite, 1107 Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, Smartphone, medicine.medical_specialty, MASK study group, Immunology, MACVIA-ARIA, 03 medical and health sciences, Allergic, medicine, Humans, TECHNOLOGY, IMMUNOTHERAPY, Asma, Asthma, business.industry, Rhinitis, Allergic, medicine.disease, RHINOCONJUNCTIVITIS, 030104 developmental biology, 030228 respiratory system, 3121 General medicine, internal medicine and other clinical medicine, Physical therapy, Clinical Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Background: In allergic rhinitis, a relevant outcome providing information on the effectiveness of interventions is needed. In MASK-air (Mobile Airways Sentinel Network), a visual analogue scale (VAS) for work is used as a relevant outcome. This study aimed to assess the performance of the work VAS work by comparing VAS work with other VAS measurements and symptom-medication scores obtained concurrently. Methods: All consecutive MASK-air users in 23 countries from 1 June 2016 to 31 October 2018 were included (14 189 users; 205 904 days). Geolocalized users self-assessed daily symptom control using the touchscreen functionality on their smart phone to click on VAS scores (ranging from 0 to 100) for overall symptoms (global), nose, eyes, asthma and work. Two symptom-medication scores were used: the modified EAACI CSMS score and the MASK control score for rhinitis. To assess data quality, the intra-individual response variability (IRV) index was calculated. Results: A strong correlation was observed between VAS work and other VAS. The highest levels for correlation with VAS work and variance explained in VAS work were found with VAS global, followed by VAS nose, eye and asthma. In comparison with VAS global, the mCSMS and MASK control score showed a lower correlation with VAS work. Results are unlikely to be explained by a low quality of data arising from repeated VAS measures. Conclusions: VAS work correlates with other outcomes (VAS global, nose, eye and asthma) but less well with a symptom-medication score. VAS work should be considered as a potentially useful AR outcome in intervention studies. © 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
Published: 2020
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6. Adherence to treatment in allergic rhinitis using mobile technology : The MASK Study

Author: Menditto, Enrica, Costa, Elisio, Midao, Luis, Bosnic-Anticevich, Sinthia, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Mair, Alpana, Rajabian-Soderlund, Rojin, Arnavielhe, Sylvie, Bedbrook, Anna, Czarlewski, Wienczyslawa, Annesi-Maesano, Isabella, Anto, Josep M., Devillier, Philippe, De Vries, Govert, Keil, Thomas, Sheikh, Aziz, Orlando, Valentina, Larenas-Linnemann, Desiree, Cecchi, Lorenzo, De Feo, Giulia, Illario, M., Stellato, Cristiana, Fonseca, Joao, Malva, Joao, Morais-Almeida, Mario, Pereira, Ana Maria, Todo-Bom, Ana Maria, Kvedariene, Violeta, Valiulis, Arunas, Bergmann, Karl Christian, Klimek, Ludger, Moesges, Ralph, Pfaar, Oliver, Zuberbier, Torsten, Cardona, Vicky, Mullol, Joaquim, Papadopoulos, Nikos G., Prokopakis, Emmanuel P., Bewick, Mike, Ryan, Dermot, Roller-Wirnsberger, Regina E., Tomazic, Peter Valentin, Cruz, Alvaro A., Kuna, Piotr, Samolinski, Boleslaw, Fokkens, Wytske J., Reitsma, Sietze, Bosse, Isabelle, Fontaine, Jean-Francois, Laune, Daniel, Haahtela, Tari, Toppila-Salmi, Sanna, Bachert, Claus, Hellings, Peter W., Melen, Erik, Wickman, Magnus, Bindslev-Jensen, Carsten, Eller, Esben, O'Hehir, Robyn E., Cingi, Cemal, Gemicioglu, Bilun, Kalayci, Omer, Ivancevich, Juan Carlos, Bousquet, Jean, Bousquet, J., Hellings, P. W., Aberer, W., Agache, I., Akdis, C. A., Akdis, M., Aliberti, M. R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiar-Dini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Basagana, X., Bateman, E. D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghe, B., Bel, E. H., Bergmann, K. C., Bennoor, K. S., Benson, M., Bertorello, L., Bialoszewski, A. Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Marciniak, M. Bochenska, Bogus-Buczynska, I., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, C. S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, Pj, Braido, F., Briedis, V., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Cabanas, M. T. Burguete, Burte, E., Bush, A., Caballero-Fonseca, F., Caillaud, D., Caimmi, D., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Canfora, G., Canonica, G. W., Cardona, V., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda, A. M., Chavannes, N. H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Coehlo, A. C. Carvalho, Colas, L., Colgan, E., Coll, J., Conforti, D., De Sousa, J. Correia, Cortes-Grimaldo, R. M., Corti, F., Costa, E., Costa-Dominguez, Mc, Al Courbis, F., Cox, L., Crescenzo, M., Cruz, A. A., Custovic, A., Czarlewski, W., Dahlen, S. E., D'Amato, Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., Emerson, M. De Fatima, De Feo, G., De Vries, G., De Martino, B., Rubina, N. P. Motta, Deleanu, D., Demoly, P., Denburg, Ja, Devillier, P., Ercolano, S. Di Capua, Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M. G., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., El-Gamal, Y., Eklund, Patrik, Eller, E., Emuzyte, R., Farrell, J., Farsi, A., De Mello, J. Ferreira, Jr., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fok-Kens, W. J., Fonseca, Ja, Fontaine, J. F., Forti, S., Fuentes-Perez, J. M., Galvez-Romero, J. L., Gamkrelidze, A., Garcia-Aymerich, J., Garcia-Cobas, C. Y., Garcia-Cruz, M. H., Gemicioglu, B., Genova, S., Christoff, G., Gereda, J. E., Van Wijk, R. Gerth, Gomez, R. M., Gomez-Vera, J., Diaz, S. Gonzalez, Gotua, M., Grisle, I., Guidacci, M., Guldemond, Na, Gutter, Z., Guzman, Ma, Haahtela, T., Hajjam, J., Hernandez, L., Houri-Hane, J O ' B, Huerta-Villalobos, Y. R., Humbert, M., Iaccarino, G., Ispayeva, Z., Ivancevich, J. C., Jares, Ej, Jassem, E., Johnston, S. L., Joos, G., Jung, K. S., Just, J., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M. 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Moura, Mullol, J., Munter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, Td, O'Hehir, Re, Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G. L., Cisneros, M. Ortega, Ouedraogo, S., Pali-Scholl, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pepin, J. L., Pereira, A. M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Pozzi, A. C., Price, D., Prokopakis, E. P., Puy, R., Pugin, B., Ross, R. E. Pulido, Przemecka, M., Rabe, K. F., Raciborski, F., Raja-Bian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Riv-Ero-Yeverino, D., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Gonzalez, M. 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T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, G., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zernotti, M. E., Zhanat, I., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., Menditto, Enrica, Costa, Elisio, Midao, Luis, Bosnic-Anticevich, Sinthia, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Mair, Alpana, Rajabian-Soderlund, Rojin, Arnavielhe, Sylvie, Bedbrook, Anna, Czarlewski, Wienczyslawa, Annesi-Maesano, Isabella, Anto, Josep M., Devillier, Philippe, De Vries, Govert, Keil, Thomas, Sheikh, Aziz, Orlando, Valentina, Larenas-Linnemann, Desiree, Cecchi, Lorenzo, De Feo, Giulia, Illario, M., Stellato, Cristiana, Fonseca, Joao, Malva, Joao, Morais-Almeida, Mario, Pereira, Ana Maria, Todo-Bom, Ana Maria, Kvedariene, Violeta, Valiulis, Arunas, Bergmann, Karl Christian, Klimek, Ludger, Moesges, Ralph, Pfaar, Oliver, Zuberbier, Torsten, Cardona, Vicky, Mullol, Joaquim, Papadopoulos, Nikos G., Prokopakis, Emmanuel P., Bewick, Mike, Ryan, Dermot, Roller-Wirnsberger, Regina E., Tomazic, Peter Valentin, Cruz, Alvaro A., Kuna, Piotr, Samolinski, Boleslaw, Fokkens, Wytske J., Reitsma, Sietze, Bosse, Isabelle, Fontaine, Jean-Francois, Laune, Daniel, Haahtela, Tari, Toppila-Salmi, Sanna, Bachert, Claus, Hellings, Peter W., Melen, Erik, Wickman, Magnus, Bindslev-Jensen, Carsten, Eller, Esben, O'Hehir, Robyn E., Cingi, Cemal, Gemicioglu, Bilun, Kalayci, Omer, Ivancevich, Juan Carlos, Bousquet, Jean, Bousquet, J., Hellings, P. W., Aberer, W., Agache, I., Akdis, C. A., Akdis, M., Aliberti, M. R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiar-Dini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Basagana, X., Bateman, E. D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghe, B., Bel, E. H., Bergmann, K. C., Bennoor, K. S., Benson, M., Bertorello, L., Bialoszewski, A. Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Marciniak, M. Bochenska, Bogus-Buczynska, I., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, C. S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, Pj, Braido, F., Briedis, V., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Cabanas, M. T. Burguete, Burte, E., Bush, A., Caballero-Fonseca, F., Caillaud, D., Caimmi, D., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Canfora, G., Canonica, G. W., Cardona, V., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda, A. M., Chavannes, N. H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Coehlo, A. C. Carvalho, Colas, L., Colgan, E., Coll, J., Conforti, D., De Sousa, J. Correia, Cortes-Grimaldo, R. M., Corti, F., Costa, E., Costa-Dominguez, Mc, Al Courbis, F., Cox, L., Crescenzo, M., Cruz, A. A., Custovic, A., Czarlewski, W., Dahlen, S. E., D'Amato, Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., Emerson, M. De Fatima, De Feo, G., De Vries, G., De Martino, B., Rubina, N. P. Motta, Deleanu, D., Demoly, P., Denburg, Ja, Devillier, P., Ercolano, S. Di Capua, Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M. G., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., El-Gamal, Y., Eklund, Patrik, Eller, E., Emuzyte, R., Farrell, J., Farsi, A., De Mello, J. Ferreira, Jr., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fok-Kens, W. J., Fonseca, Ja, Fontaine, J. F., Forti, S., Fuentes-Perez, J. M., Galvez-Romero, J. L., Gamkrelidze, A., Garcia-Aymerich, J., Garcia-Cobas, C. Y., Garcia-Cruz, M. H., Gemicioglu, B., Genova, S., Christoff, G., Gereda, J. E., Van Wijk, R. Gerth, Gomez, R. M., Gomez-Vera, J., Diaz, S. Gonzalez, Gotua, M., Grisle, I., Guidacci, M., Guldemond, Na, Gutter, Z., Guzman, Ma, Haahtela, T., Hajjam, J., Hernandez, L., Houri-Hane, J O ' B, Huerta-Villalobos, Y. R., Humbert, M., Iaccarino, G., Ispayeva, Z., Ivancevich, J. C., Jares, Ej, Jassem, E., Johnston, S. L., Joos, G., Jung, K. S., Just, J., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Falta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L. T. T., Lessa, M., Levato, G., Li, J., Lieberman, P., Liplec, A., Lipworth, B., Carlsen, K. C. Lodrup, Louis, R., Lourenco, O., Luna-Pech, J. A., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., Keenoy, E. De Manuel, Marshall, G. D., Masjedi, M. R., Maspero, J. F., Mathieu-Dupas, E., Campos, J. J. Matta, Matos, Al, Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M. A., Melen, E., Melo-Gomes, E., Meltzer, Eo, Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. D., Mohammad, Y., Momas, I., Monte-Fort, S., Monti, R., Bogado, D. Mora, Morais-Almeida, M., Morato-Castro, Mosges, R., Mota-Pinto, A., Santo, P. Moura, Mullol, J., Munter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, Td, O'Hehir, Re, Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G. L., Cisneros, M. Ortega, Ouedraogo, S., Pali-Scholl, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pepin, J. L., Pereira, A. M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Pozzi, A. C., Price, D., Prokopakis, E. P., Puy, R., Pugin, B., Ross, R. E. Pulido, Przemecka, M., Rabe, K. F., Raciborski, F., Raja-Bian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Riv-Ero-Yeverino, D., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Gonzalez, M. Rodriguez, Rodriguez-Manas, L., Rolland, C., Valle, S. Rodrigues, Rodriguez, M. Roman, Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R. E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimaki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schunemann, H. J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F. S., Shamai, S., Sheikh, A., Sierra, M., Simons, F. E. R., Sir-Oux, V., Sisul, J. C., Skrindo, I., Sole, D., Somekh, D., Sonder-Mann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyrica, Jn, Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P. V., Toppila-Salmi, S., Trama, U., Triggiani, M., Ulrik, C. Suppli, Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., Van Eerd, M., Van Ganse, E., Van Hague, M., Vandenplas, O., Ventura, M. T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, G., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zernotti, M. E., Zhanat, I., Zidarn, M., Zuberbier, T., Zubrinich, C., and Zurkuhlen, A.
Abstract: Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12143 users were registered. A total of 6949 users reported at least one VAS data recording. Among them, 1887 users reported >= 7 VAS data. About 1195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR >= 70% and PDC <= 1.25), 51 (4.23%) were partly adherent (MPR >= 70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users. Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.
Published: 2019
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7. Differences in Reporting the Ragweed Pollen Season Using Google Trends across 15 Countries

Author: Bousquet J1, Agache I, Berger U, Bergmann KC, Besancenot JP, Bousquet PJ, Casale T, d'Amato G, Kaidashev I1, Khaitov M1, Mösges R, Nekam K, Onorato GL, Plavec D, Sheikh A, Thibaudon M, Vautard R, Zidarn M.
Subjects: Allergy, Hay fever, Pollen, Ragweed, Rhinitis
Abstract: BACKGROUND: Google Trends (GT) searches trends of specific queries in Google, which potentially reflect the real-life epidemiology of allergic rhinitis. We compared GT terms related to ragweed pollen allergy in American and European Union countries with a known ragweed pollen season. Our aim was to assess seasonality and the terms needed to perform the GT searches and to compare these during the spring and summer pollen seasons. METHODS: We examined GT queries from January 1, 2011, to January 4, 2017. We included 15 countries with a known ragweed pollen season and used the standard 5-year GT graphs. We used the GT translation for all countries and the untranslated native terms for each country. RESULTS: The results of "pollen, " "ragweed, " and "allergy" searches differed between countries, but "ragweed" was clearly identified in 12 of the 15 countries. There was considerable heterogeneity of findings when the GT translation was used. For Croatia, Hungary, Romania, Serbia, and Slovenia, the GT translation was inappropriate. The country patterns of "pollen, " "hay fever, " and "allergy" differed in 8 of the 11 countries with identified "ragweed" queries during the spring and the summer, indicating that the perception of tree and grass pollen allergy differs from that of ragweed pollen. CONCLUSIONS: To investigate ragweed pollen allergy using GT, the term "ragweed" as a plant is required and the translation of "ragweed" in the native language needed.
Published: 2018

8. Severe Chronic Allergic (and Related) Diseases: A Uniform Approach - A MeDALL - GA(2)LEN - ARIA Position Paper

Author: WHO Collaborating Center for Asthma, Rhinitis, Bousquet J, Anto JM, Demoly P, Schünemann HJ, Togias A, Akdis M, Auffray C, Bachert C, Bieber T, Bousquet PJ, Carlsen KH, Casale TB, Cruz AA, Keil T, Lodrup Carlsen KC, Maurer M, Ohta K, Papadopoulos NG, Roman Rodriguez M, Samolinski B, Agache I, Andrianarisoa A, Ang CS, Annesi Maesano I, Ballester F, Baena Cagnani CE, Basagaña X, Bateman ED, Bel EH, Bedbrook A, Beghé B, Beji M, Ben Kheder A, Benet M, Bennoor KS, Bergmann KC, Berrissoul F, Bindslev Jensen C, Bleecker ER, BONINI, Sergio, WHO Collaborating Center for, Asthma, Rhinitis, Bousquet, J, Anto, Jm, Demoly, P, Schünemann, Hj, Togias, A, Akdis, M, Auffray, C, Bachert, C, Bieber, T, Bousquet, Pj, Carlsen, Kh, Casale, Tb, Cruz, Aa, Keil, T, Lodrup Carlsen, Kc, Maurer, M, Ohta, K, Papadopoulos, Ng, Roman Rodriguez, M, Samolinski, B, Agache, I, Andrianarisoa, A, Ang, C, Annesi Maesano, I, Ballester, F, Baena Cagnani, Ce, Basagaña, X, Bateman, Ed, Bel, Eh, Bedbrook, A, Beghé, B, Beji, M, Ben Kheder, A, Benet, M, Bennoor, K, Bergmann, Kc, Berrissoul, F, Bindslev Jensen, C, Bleecker, Er, and Bonini, Sergio
Published: 2013

9. Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author: Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, EH, Bewick, M, Chavannes, NH, De Sousa, JC, Cruz, AA, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, CA, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, IJ, Anto, JM, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, AK, Barbara, C, Bateman, ED, Beghé, B, Kheder, AB, Bennoor, KS, Benson, M, Bergmann, KC, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, AL, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, LP, Bourret, R, Bousquet, PJ, Braido, F, Briggs, AH, Brightling, CE, Brozek, J, Buhl, R, Burney, PG, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, MA, Calverley, PM, Camargos, PAM, Canonica, GW, Camuzat, T, Carlsen, KH, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, AM, Chatzi, L, Chen, YZ, Chiron, R, Chkhartishvili, E, Chuchalin, AG, Chung, KF, Ciprandi, G, Cirule, I, Cox, L, Costa, DJ, Custovic, A, Dahl, R, Dahlen, SE, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, JA, Devillier, P, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, EH, Bewick, M, Chavannes, NH, De Sousa, JC, Cruz, AA, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, CA, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, IJ, Anto, JM, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, AK, Barbara, C, Bateman, ED, Beghé, B, Kheder, AB, Bennoor, KS, Benson, M, Bergmann, KC, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, AL, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, LP, Bourret, R, Bousquet, PJ, Braido, F, Briggs, AH, Brightling, CE, Brozek, J, Buhl, R, Burney, PG, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, MA, Calverley, PM, Camargos, PAM, Canonica, GW, Camuzat, T, Carlsen, KH, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, AM, Chatzi, L, Chen, YZ, Chiron, R, Chkhartishvili, E, Chuchalin, AG, Chung, KF, Ciprandi, G, Cirule, I, Cox, L, Costa, DJ, Custovic, A, Dahl, R, Dahlen, SE, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, JA, and Devillier, P
Published: 2017

10. Practical guide to skin prick tests in allergy to aeroallergens

Author: Bousquet, J, Heinzerling, L, Bachert, C, Papadopoulos, NG, Bousquet, PJ, Burney, PG, Canonica, GW, Carlsen, KH, Cox, L, Haahtela, T, Carlsen, KCL, Price, D, Samolinski, B, Simons, FER, Wickman, M, Annesi-Maesano, I, Baena-Cagnani, CE, Bergmann, KC, Bindslev-Jensen, C, Casale, TB, Chiriac, A, Cruz, AA, Dubakiene, R, Durham, SR, Fokkens, WJ, Gerth van Wijk, Roy, Kalayci, O, Kowalski, ML, Mari, A, Mullol, J, Nazamova-Baranova, L, O'Hehir, RE, Ohta, K, Panzner, P, Passalacqua, G, Ring, J, Rogala, B, Romano, A, Ryan, D, Schmid-Grendelmeier, P, Todo-Bom, A, Valenta, R, Woehrl, S, Yusuf, OM, Zuberbier, T, Demoly, P, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Dermatology, Medical School-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Bousquet J, Heinzerling L, Bindslev-Jensen C, Casale TB, Bachert C, Chiriac A, Cruz AA, Dubakiene R, Durham SR, Fokkens WJ, Gerth-van-Wijk R, Kalayci O, Lodrup Carlsen KC, Kowalski ML, Mari A, Mullol J, Papadopoulos NG, Nazamova-Baranova L, O'Hehir RE, Ohta K, Panzner P, Passalacqua G, Ring J, Price D, Rogala B, Romano A, Ryan D, Schmid-Grendelmeier P, Bousquet PJ, Todo-Bom A, Valenta R, Woehrl S, Yusuf OM, Zuberbier T, Samolinski B, Demoly P, Burney PG, Canonica GW, Carlsen KH, Cox L, Haahtela T, Simons FE, Wickman M, Annesi-Maesano I, Baena-Cagnani CE, Bergmann KC, AII - Amsterdam institute for Infection and Immunity, Ear, Nose and Throat, University of Zurich, Bousquet, J, Dermatology, and Internal Medicine
Subjects: 2403 Immunology, Air Pollutants, 2723 Immunology and Allergy, Hypersensitivity, 10177 Dermatology Clinic, Humans, 610 Medicine & health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Allergens, Skin Tests
Abstract: International audience; To cite this article: Bousquet J, Heinzerling L, Bachert C, Papadopoulos NG, Bousquet PJ, Burney PG, Canonica GW, Carlsen KH, Cox L, Haahtela T, Lodrup Carlsen KC, Price D, Samolinski B, Simons FER, Wickman M, Annesi-Maesano I, Baena-Cagnani CE, Bergmann KC, Bindslev-Jensen C, Casale TB, Chiriac A, Cruz AA, Dubakiene R, Durham SR, Fokkens WJ, Gerth-van-Wijk R, Kalayci O, Kowalski ML, Mari A, Mullol J, Nazamova-Baranova L, O'Hehir RE, Ohta K, Panzner P, Passalacqua G, Ring J, Rogala B, Romano A, Ryan D, Schmid-Grendelmeier P, Todo-Bom A, Valenta R, Woehrl S, Yusuf OM, Zuberbier T, Demoly P. Practical guide to skin prick tests in allergy to aeroallergens. Allergy 2011; DOI: 10.1111/j.1398-9995.2011.02728.x ABSTRACT: This pocket guide is the result of a consensus reached between members of the Global Allergy and Asthma European Network (GA(2) LEN) and Allergic Rhinitis and its Impact on Asthma (ARIA). The aim of the current pocket guide is to offer a comprehensive set of recommendations on the use of skin prick tests in allergic rhinitis-conjunctivitis and asthma in daily practice. This pocket guide is meant to give simple answers to the most frequent questions raised by practitioners in Europe, including 'practicing allergists', general practitioners and any other physicians with special interest in the management of allergic diseases. It is not a long or detailed scientific review of the topic. However, the recommendations in this pocket guide were compiled following an in-depth review of existing guidelines and publications, including the 1993 European Academy of Allergy and Clinical Immunology position paper, the 2001 ARIA document and the ARIA update 2008 (prepared in collaboration with GA(2) LEN). The recommendations cover skin test methodology and interpretation, allergen extracts to be used, as well as indications in a variety of settings including paediatrics and developing countries.
Published: 2011
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11. Development and implementation of guidelines in allergic rhinitis - an ARIA-GA2LEN paper

Author: Bousquet, J, Schünemann, Hj, Zuberbier, T, Bachert, C, Baena Cagnani CE, Bousquet, Pj, Brozek, J, Canonica, Giorgio, Casale, Tb, Demoly, P, Gerth van Wijk, R, Ohta, K, Bateman, Ed, Calderon, M, Cruz, Aa, Dolen, Wk, Haughney, J, Lockey, Rf, Lötvall, J, O'Byrne, P, Spranger, O, Togias, A, Bonini, S, Boulet, Lp, Camargos, P, Carlsen, Kh, Chavannes, Nh, Delgado, L, Durham, Sr, Fokkens, Wj, Fonseca, J, Haahtela, T, Kalayci, O, Kowalski, Ml, Larenas Linnemann, D, Li, J, Mohammad, Y, Mullol, J, Naclerio, R, O'Hehir, Re, Papadopoulos, N, Passalacqua, G, Rabe, Kf, Pawankar, R, Ryan, D, Samolinski, B, Simons, Fe, Valovirta, E, Yorgancioglu, A, Yusuf, Om, Agache, I, Aït Khaled, N, Annesi Maesano, I, Beghe, B, Ben Kheder, A, Blaiss, Ms, Boakye, Da, Bouchard, J, Burney, Pg, Busse, Ww, Chan Yeung, M, Chen, Y, Chuchalin, Ag, Costa, Dj, Custovic, A, Dahl, R, Denburg, J, Douagui, H, Emuzyte, R, Grouse, L, Humbert, M, Jackson, C, Johnston, Sl, Kaliner, Ma, Keith, Pk, Kim, Yy, Klossek, Jm, Kuna, P, Le, Lt, Lemiere, C, Lipworth, B, Mahboub, B, Malo, Jl, Marshall, Gd, Mavale Manuel, S, Meltzer, Eo, Morais Almeida, M, Motala, C, Naspitz, C, Nekam, K, Niggemann, B, Nizankowska Mogilnicka, E, Okamoto, Y, Orru, Mp, Ouedraogo, S, Palkonen, S, Popov, Ta, Price, D, Rosado Pinto, J, Scadding, Gk, Sooronbaev, Tm, Stoloff, Sw, Toskala, E, van Cauwenberge, P, Vandenplas, O, van Weel, C, Viegi, G, Virchow, Jc, Wang, Dy, Wickman, M, Williams, D, Yawn, Bp, Zar, Hj, Zernotti, M, Zhong, N, In collaboration with the WHO Collaborating Center of Asthma, Rhinitis, Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Department of Dermatology, Medical School-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Photochimie moléculaire et macromoléculaire (PMM), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), P&A Kyriakou Children's Hospital, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), inconnu, Inconnu, Forschungszentrum Jülich GmbH - Projektträger BEO, GmbH, Laboratoire d'étude des textures et application aux matériaux (LETAM), Université Paul Verlaine - Metz (UPVM)-Centre National de la Recherche Scientifique (CNRS), Merlin Circuit Technology LTD, Institute for Meteorology and Climate Research (IMK), Karlsruhe Institute of Technology (KIT), Physics Department [UNB], University of New Brunswick (UNB), Bousquet J, Schünemann HJ, R Gerth van Wijk, K Ohta, Bateman ED, M Calderon, Cruz AA, Dolen WK, Haughney J, Lockey RF, Lötvall J, P O'Byrne, Zuberbier T, O Spranger, Togias A, S Bonini, LP Boulet, P Camargos, KH Carlsen, Chavannes NH, L Delgado, SR Durham, Fokkens WJ, C Bachert, Fonseca J, Haahtela T, O Kalayci, ML Kowalski, Larenas-Linnemann D, Li J, Y Mohammad, Mullol J, R Naclerio, RE O'Hehir, Baena-Cagnani CE, N Papadopoulos, G Passalacqua, KF Rabe, R Pawankar, Ryan D, B Samolinski, Simons FE, E Valovirta, Yorgancioglu A, Yusuf OM, Bousquet PJ, je Agache, Khaled N-Aït, Annesi-Maesano I, B Begge, Kheder Ben A, MS Blaiss, DA Boakye, Bouchard J, PG Burney, WW Busse, Brozek J, M Chan-Yeung, Y Chen, AG Chuchalin, Costa DJ, Custovic A, R Dahl, Denburg J, H Douagui, R Emuzyte, L Grouse, GW Canonica, M Humbert, C Jackson, SL Johnston, MA Kaliner, Keith PK, YY Kim, JM Klossek, P Kun, la tuberculose Casale, Demoly P, AII - Amsterdam institute for Infection and Immunity, Ear, Nose and Throat, UCL - (MGD) Service de pneumologie, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut de Chimie du CNRS (INC), and Internal Medicine
Subjects: Evidence-Based Medicine, Rhinitis, Allergic, Perennial, MESH: Humans, treatment, MESH: Asthma, MESH: Rhinitis, Allergic, Perennial, rhinitis, asthma, guidelines, Disease Management, Rhinitis, Allergic, Seasonal, MESH: Rhinitis, Allergic, Seasonal, Planning Techniques, MESH: Planning Techniques, MESH: Disease Management, Asthma, MESH: Practice Guidelines as Topic, Practice Guidelines as Topic, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ARIA asthma EAACI EFA GA2LEN IPCRG rhinitis nonallergic rhinitis controlled-trial severe asthma randomized-trials consort statement primary-care 2008 update recommendations management quality, MESH: Evidence-Based Medicine
Abstract: International audience; The links between asthma and rhinitis are well characterized. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines stress the importance of these links and provide guidance for their prevention and treatment. Despite effective treatments being available, too few patients receive appropriate medical care for both diseases. Most patients with rhinitis and asthma consult primary care physicians and therefore these physicians are encouraged to understand and use ARIA guidelines. Patients should also be informed about these guidelines to raise their awareness of optimal care and increase control of the two related diseases. To apply these guidelines, clinicians and patients need to understand how and why the recommendations were made. The goal of the ARIA guidelines is to provide recommendations about the best management options for most patients in most situations. These recommendations should be based on the best available evidence. Making recommendations requires the assessment of the quality of available evidence, deciding on the balance between benefits and downsides, consideration of patients' values and preferences, and, if applicable, resource implications. Guidelines must be updated as new management options become available or important new evidence emerges. Transparent reporting of guidelines facilitates understanding and acceptance, but implementation strategies need to be improved.
Published: 2010
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12. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)

Author: Bousquet, J, Khaltaev, N, Cruz, Aa, Denburg, J, Fokkens, Wj, Togias, A, Zuberbier, T, Baena Cagnani CE, Canonica, Giorgio, van Weel, C, Agache, I, Aït Khaled, N, Bachert, C, Blaiss, Ms, Bonini, S, Boulet, Lp, Bousquet, Pj, Camargos, P, Carlsen, Kh, Chen, Y, Custovic, A, Dahl, R, Demoly, P, Douagui, H, Durham, Sr, van Wijk RG, Kalayci, O, Kaliner, Ma, Kim, Yy, Kowalski, Ml, Kuna, P, Le, Lt, Lemiere, C, Li, J, Lockey, Rf, Mavale Manuel, S, Meltzer, Eo, Mohammad, Y, Mullol, J, Naclerio, R, O'Hehir, Re, Ohta, K, Ouedraogo, S, Palkonen, S, Papadopoulos, N, Passalacqua, Giovanni, Pawankar, R, Popov, Ta, Rabe, Kf, Rosado Pinto, J, Scadding, Gk, Simons, Fe, Toskala, E, Valovirta, E, van Cauwenberge, P, Wang, Dy, Wickman, M, Yawn, Bp, Yorgancioglu, A, Yusuf, Om, Zar, H, Annesi Maesano, I, Bateman, Ed, Ben Kheder, A, Boakye, Da, Bouchard, J, Burney, P, Busse, Ww, Chan Yeung, M, Chavannes, Nh, Chuchalin, A, Dolen, Wk, Emuzyte, R, Grouse, L, Humbert, M, Jackson, C, Johnston, Sl, Keith, Pk, Kemp, Jp, Klossek, Jm, Larenas Linnemann, D, Lipworth, B, Malo, Jl, Marshall, Gd, Naspitz, C, Nekam, K, Niggemann, B, Nizankowska Mogilnicka, E, Okamoto, Y, Orru, Mp, Potter, P, Price, D, Stoloff, Sw, Vandenplas, O, Viegi, G, Williams, D, World Health Organization, Galen, Allergen, Bousquet, J, Khaltaev, N, Cruz, Aa, Denburg, J, Fokkens, Wj, Togias, A, Zuberbier, T, BAENA CAGNANI, Ce, Canonica, Gw, VAN WEEL, C, Agache, I, AÏT KHALED, N, Bachert, C, Blaiss, M, Bonini, Sergio, Boulet, Lp, Bousquet, Pj, Camargos, P, Carlsen, Kh, Chen, Y, Custovic, A, Dahl, R, Demoly, P, Douagui, H, Durham, Sr, VAN WIJK, Rg, Kalayci, O, Kaliner, Ma, Kim, Yy, Kowalski, Ml, Kuna, P, Le, Lt, Lemiere, C, Li, J, Lockey, Rf, MAVALE MANUEL, S, Meltzer, Eo, Mohammad, Y, Mullol, J, Naclerio, R, O'Hehir, Re, Ohta, K, Ouedraogo, S, Palkonen, S, Papadopoulos, N, Passalacqua, G, Pawankar, R, Popov, Ta, Rabe, Kf, ROSADO PINTO, J, Scadding, Gk, Simons, Fe, Toskala, E, Valovirta, E, VAN CAUWENBERGE, P, Wang, Dy, Wickman, M, Yawn, Bp, Yorgancioglu, A, Yusuf, Om, Zar, H, ANNESI MAESANO, I, Bateman, Ed, BEN KHEDER, A, Boakye, Da, Bouchard, J, Burney, P, Busse, Ww, CHAN YEUNG, M, Chavannes, Nh, Chuchalin, A, Dolen, Wk, Emuzyte, R, Grouse, L, Humbert, M, Jackson, C, Johnston, Sl, Keith, Pk, Kemp, Jp, Klossek, Jm, LARENAS LINNEMANN, D, Lipworth, B, Malo, Jl, Marshall, Gd, Naspitz, C, Nekam, K, Niggemann, B, NIZANKOWSKA MOGILNICKA, E, Okamoto, Y, Orru, Mp, Potter, P, Price, D, Stoloff, Sw, Vandenplas, O, Viegi, G, Williams, D, WORLD HEALTH, Organization, and Galen, Allergen
Published: 2008

13. ARIA-suggested drugs for allergic rhinitis: what impact on quality of life? A GA2LEN review

Author: Baiardini, I, Braido, Fulvio, Tarantini, F, Porcu, A, Bonini, S, Bousquet, Pj, Zuberbier, T, Demoly, P, Canonica, Giorgio, Ga2len, Baiardini, I, Braido, F, Tarantini, F, Porcu, A, Bonini, Sergio, Bousquet, Pj, Zuberbier, T, Demoly, P, Canonica, Gw, and Galen
Subjects: medicine.medical_specialty, Allergy, Rhinitis, Allergic, Perennial, Immunology, MEDLINE, Disease, rhinitis, Quality of life (healthcare), Cost of Illness, Surveys and Questionnaires, Anti-Allergic Agents, Health care, medicine, Global health, Humans, Immunology and Allergy, allergic rhinitis and its impact on asthma, Randomized Controlled Trials as Topic, Asthma, business.industry, Drug Administration Routes, Health services research, Rhinitis, Allergic, Seasonal, medicine.disease, Surgery, Desensitization, Immunologic, Family medicine, Quality of Life, Health Services Research, Immunotherapy, business
Abstract: Allergic diseases constitute a global health problem, as they have an increasing economic and social impact and, especially, they can deeply interfere with the patients' daily life, being a cause of physical and emotional discomfort. This is why the health-related quality-of-life (HRQoL) has become increasingly important in health care research; in fact, the assessment of the impact the disease and its treatment have on patients, provides a more comprehensive approach in outcome evaluation. Numerous validated questionnaires are available and many studies have been performed evaluating HRQoL in people affected by allergic rhinitis (AR), thus testifying a great interest in this topic. The aims of the present review are: to examine the scientific literature of the last 3 years dealing with the impact of AR treatments suggested by allergic rhinitis and its impact on asthma guidelines on patients' QoL, and to identify the unexplored or not-fully-investigated areas concerning this issue.
Published: 2008

14. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author: Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, EH, Bewick, M, Chavannes, NH, De Sousa, JC, Cruz, AA, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, CA, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, IJ, Anto, JM, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, AK, Barbara, C, Bateman, ED, Beghé, B, Kheder, AB, Bennoor, KS, Benson, M, Bergmann, KC, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, AL, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, LP, Bourret, R, Bousquet, PJ, Braido, F, Briggs, AH, Brightling, CE, Brozek, J, Buhl, R, Burney, PG, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, MA, Calverley, PM, Camargos, PAM, Canonica, GW, Camuzat, T, Carlsen, KH, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, AM, Chatzi, L, Chen, YZ, Chiron, R, Chkhartishvili, E, Chuchalin, AG, Chung, KF, Ciprandi, G, Cirule, I, Cox, L, Costa, DJ, Custovic, A, Dahl, R, Dahlen, SE, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, JA, Devillier, P, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, EH, Bewick, M, Chavannes, NH, De Sousa, JC, Cruz, AA, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, CA, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, IJ, Anto, JM, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, AK, Barbara, C, Bateman, ED, Beghé, B, Kheder, AB, Bennoor, KS, Benson, M, Bergmann, KC, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, AL, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, LP, Bourret, R, Bousquet, PJ, Braido, F, Briggs, AH, Brightling, CE, Brozek, J, Buhl, R, Burney, PG, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, MA, Calverley, PM, Camargos, PAM, Canonica, GW, Camuzat, T, Carlsen, KH, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, AM, Chatzi, L, Chen, YZ, Chiron, R, Chkhartishvili, E, Chuchalin, AG, Chung, KF, Ciprandi, G, Cirule, I, Cox, L, Costa, DJ, Custovic, A, Dahl, R, Dahlen, SE, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, JA, and Devillier, P
Abstract: © 2016 The Author(s). Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing.
Published: 2016

15. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

Author: Bousquet, J, Hellings, PW, Agache, I, Bedbrook, A, Bachert, C, Bergmann, KC, Bewick, M, Bindslev-Jensen, C, Bosnic-Anticevitch, S, Bucca, C, Caimmi, D P, Camargos, PAM, Canonica, GW, Casale, T, Chavannes, NH, Cruz, AA, De Carlo, G, Dahl, R, Demoly, P, Devillier, P, Fonseca, J, Fokkens, WJ, Guldemond, Nick, Haahtela, T, Illario, M, Just, J, Keil, T, Klimek, L, Kuna, P, Larenas-Linnemann, D, Morais-Almeida, M, Mullol, J, Murray, R, Naclerio, R, O'Hehir, RE, Papadopoulos, NG, Pawankar, R, Potter, P, Ryan, D, Samolinski, B, Schunemann, HJ, Sheikh, A (Aziz), Simons, FER, Stellato, C, Todo-Bom, A, Tomazic, PV, Valiulis, A, Valovirta, E, Ventura, M T, Wickman, M, Young, I, Yorgancioglu, A, Zuberbier, T, Aberer, W, Akdis, CA, Akdis, M, Annesi-Maesano, I, Ankri, J, Ansotegui, IJ, Anto, JM, Arnavielhe, S, Asarnoj, A, Arshad, H, Avolio, F, Baiardini, I, Barbara, C, Barbagallo, M, Bateman, ED, Beghé, B, Bel, EH, Bennoor, KS, Benson, M, Bia?oszewski, AZ, Bieber, T, Bjermer, L, Blain, H, Blasi, F, Boner, AL, Bonini, M, Bonini, S, Bosse, I, Bouchard, J, Boulet, LP, Bourret, R, Bousquet, PJ, Braido, F, Briggs, AH, Brightling, CE, Brozek, J, Buhl, R, Bunu, C, Burte, E, Bush, A, Caballero-Fonseca, F, Calderon, MA, Camuzat, T, Cardona, V, Carreiro-Martins, P, Carriazo, AM, Carlsen, KH, Carr, W, Cepeda Sarabia, AM, Cesari, M, Chatzi, L, Chiron, R, Chivato, T, Chkhartishvili, E, Chuchalin, AG, Chung, KF, Ciprandi, G, de Sousa, JC, Cox, L, Crooks, G, Custovic, A, Dahlen, SE, Darsow, U, Dedeu, T, Deleanu, D, Denburg, JA, de Vries, G, Didier, A, Dinh-Xuan, AT, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, SR, Du Toit, G, Dykewicz, MS, Eklund, P, El-Gamal, Y, Ellers, E, Emuzyte, R, Farrell, J, Wagner, A, Fiocchi, A, Fletcher, M, Forastiere, F, Gaga, M, Gamkrelidze, A, Gemicio?lu, B, Gereda, JE, Gerth van Wijk, Roy, González Diaz, S, Grisle, I, Grouse, L, Gutter, Z, Guzmán, MA, Hellquist-Dahl, B, Heinrich, J, Horak, F, Hourihane, JOB, Humbert, M, Hyland, M, Iaccarino, G, Jares, EJ, Jeandel, C, Johnston, SL, Joos, G, Jonquet, O, Jung, KS, Jutel, M, Kaidashev, I, Khaitov, M, Kalayci, O, Kalyoncu, AF, Kardas, P, Keith, PK, Kerkhof, M, Kerstjens, HAM, Khaltaev, N, Kogevinas, M, Kolek, V, Koppelman, GH, Kowalski, ML, Kuitunen, M, Kull, I, Kvedariene, V, Lambrecht, Bart, Lau, S, Laune, D, Le, LTT, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, KC, Louis, R, Lupinek, C, MacNee, W, Magar, Y, Magnan, A, Mahboub, B, Maier, D, Majer, Istvan, Malva, J, Manning, P, De Manuel Keenoy, E, Marshall, GD, Masjedi, MR, Mathieu-Dupas, E, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, EO, Mercier, J, Merk, H, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mohammad, Y, Momas, I, Mösges, R, Muraro, A, Namazova-Baranova, L, Nadif, R, Neffen, H, Nekam, K, Nieto, A, Niggemann, B, Nogueira-Silva, L, Nogues, M, Nyembue, TD, Ohta, K, Okamoto, Y, Okubo, K, Olive-Elias, M, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Palkonen, S, Panzner, P, Papi, A, Park, HS, Passalacqua, G, Pedersen, S, Pereira, AM, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Pohl, W, Popov, TA, Portejoie, F, Postma, D, Poulsen, LK, Price, D, Rabe, KF, Raciborski, F, Roberts, G, Robalo-Cordeiro, C, Rodenas, F, Rodriguez-Mañas, L, Rolland, C, Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rottem, M, Sanchez-Borges, M, Sastre-Dominguez, J, Scadding, GK, Scichilone, N, Schmid-Grendelmeier, P, Serrano, E, Shields, M, Siroux, V, Sisul, JC, Skrindo, I, Smit, HA, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, PJ, Strandberg, T, Sunyer, J, Thijs, C, Triggiani, M, Valenta, R, Valero, A, van Eerd, M, van Ganse, E, Van Hague, M, Vandenplas, O, Varona, LL, Vellas, B, Vezzani, G, Vazankari, T, Viegi, G, Vontetsianos, T, Wagenmann, M, Walker, S, Wang, DY, Wahn, U, Werfel, T, Whalley, B, Williams, DM, Williams, S, Wilson, N, Wright, J, Yawn, BP, Yiallouros, PK, Yusuf, OM, Zaidi, A, Zar, HJ, Zernotti, ME, Zhang, L, Zhong, N, Zidarn, M, Bousquet, J, Hellings, PW, Agache, I, Bedbrook, A, Bachert, C, Bergmann, KC, Bewick, M, Bindslev-Jensen, C, Bosnic-Anticevitch, S, Bucca, C, Caimmi, D P, Camargos, PAM, Canonica, GW, Casale, T, Chavannes, NH, Cruz, AA, De Carlo, G, Dahl, R, Demoly, P, Devillier, P, Fonseca, J, Fokkens, WJ, Guldemond, Nick, Haahtela, T, Illario, M, Just, J, Keil, T, Klimek, L, Kuna, P, Larenas-Linnemann, D, Morais-Almeida, M, Mullol, J, Murray, R, Naclerio, R, O'Hehir, RE, Papadopoulos, NG, Pawankar, R, Potter, P, Ryan, D, Samolinski, B, Schunemann, HJ, Sheikh, A (Aziz), Simons, FER, Stellato, C, Todo-Bom, A, Tomazic, PV, Valiulis, A, Valovirta, E, Ventura, M T, Wickman, M, Young, I, Yorgancioglu, A, Zuberbier, T, Aberer, W, Akdis, CA, Akdis, M, Annesi-Maesano, I, Ankri, J, Ansotegui, IJ, Anto, JM, Arnavielhe, S, Asarnoj, A, Arshad, H, Avolio, F, Baiardini, I, Barbara, C, Barbagallo, M, Bateman, ED, Beghé, B, Bel, EH, Bennoor, KS, Benson, M, Bia?oszewski, AZ, Bieber, T, Bjermer, L, Blain, H, Blasi, F, Boner, AL, Bonini, M, Bonini, S, Bosse, I, Bouchard, J, Boulet, LP, Bourret, R, Bousquet, PJ, Braido, F, Briggs, AH, Brightling, CE, Brozek, J, Buhl, R, Bunu, C, Burte, E, Bush, A, Caballero-Fonseca, F, Calderon, MA, Camuzat, T, Cardona, V, Carreiro-Martins, P, Carriazo, AM, Carlsen, KH, Carr, W, Cepeda Sarabia, AM, Cesari, M, Chatzi, L, Chiron, R, Chivato, T, Chkhartishvili, E, Chuchalin, AG, Chung, KF, Ciprandi, G, de Sousa, JC, Cox, L, Crooks, G, Custovic, A, Dahlen, SE, Darsow, U, Dedeu, T, Deleanu, D, Denburg, JA, de Vries, G, Didier, A, Dinh-Xuan, AT, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, SR, Du Toit, G, Dykewicz, MS, Eklund, P, El-Gamal, Y, Ellers, E, Emuzyte, R, Farrell, J, Wagner, A, Fiocchi, A, Fletcher, M, Forastiere, F, Gaga, M, Gamkrelidze, A, Gemicio?lu, B, Gereda, JE, Gerth van Wijk, Roy, González Diaz, S, Grisle, I, Grouse, L, Gutter, Z, Guzmán, MA, Hellquist-Dahl, B, Heinrich, J, Horak, F, Hourihane, JOB, Humbert, M, Hyland, M, Iaccarino, G, Jares, EJ, Jeandel, C, Johnston, SL, Joos, G, Jonquet, O, Jung, KS, Jutel, M, Kaidashev, I, Khaitov, M, Kalayci, O, Kalyoncu, AF, Kardas, P, Keith, PK, Kerkhof, M, Kerstjens, HAM, Khaltaev, N, Kogevinas, M, Kolek, V, Koppelman, GH, Kowalski, ML, Kuitunen, M, Kull, I, Kvedariene, V, Lambrecht, Bart, Lau, S, Laune, D, Le, LTT, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, KC, Louis, R, Lupinek, C, MacNee, W, Magar, Y, Magnan, A, Mahboub, B, Maier, D, Majer, Istvan, Malva, J, Manning, P, De Manuel Keenoy, E, Marshall, GD, Masjedi, MR, Mathieu-Dupas, E, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, EO, Mercier, J, Merk, H, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mohammad, Y, Momas, I, Mösges, R, Muraro, A, Namazova-Baranova, L, Nadif, R, Neffen, H, Nekam, K, Nieto, A, Niggemann, B, Nogueira-Silva, L, Nogues, M, Nyembue, TD, Ohta, K, Okamoto, Y, Okubo, K, Olive-Elias, M, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Palkonen, S, Panzner, P, Papi, A, Park, HS, Passalacqua, G, Pedersen, S, Pereira, AM, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Pohl, W, Popov, TA, Portejoie, F, Postma, D, Poulsen, LK, Price, D, Rabe, KF, Raciborski, F, Roberts, G, Robalo-Cordeiro, C, Rodenas, F, Rodriguez-Mañas, L, Rolland, C, Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rottem, M, Sanchez-Borges, M, Sastre-Dominguez, J, Scadding, GK, Scichilone, N, Schmid-Grendelmeier, P, Serrano, E, Shields, M, Siroux, V, Sisul, JC, Skrindo, I, Smit, HA, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, PJ, Strandberg, T, Sunyer, J, Thijs, C, Triggiani, M, Valenta, R, Valero, A, van Eerd, M, van Ganse, E, Van Hague, M, Vandenplas, O, Varona, LL, Vellas, B, Vezzani, G, Vazankari, T, Viegi, G, Vontetsianos, T, Wagenmann, M, Walker, S, Wang, DY, Wahn, U, Werfel, T, Whalley, B, Williams, DM, Williams, S, Wilson, N, Wright, J, Yawn, BP, Yiallouros, PK, Yusuf, OM, Zaidi, A, Zar, HJ, Zernotti, ME, Zhang, L, Zhong, N, and Zidarn, M
Published: 2016

16. Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs

Author: Bousquet J, Schünemann HJ, Samolinski B, Demoly P, Baena-Cagnani CE, Bachert C, Bonini S, Boulet LP, Bousquet PJ, Brozek JL, Canonica GW, Casale TB, Cruz AA, Fokkens WJ, Fonseca JA, van Wijk RG, Grouse L, Haahtela T, Khaltaev N, Kuna P, Lockey RF, Lodrup Carlsen KC, Mullol J, Naclerio R, O'Hehir RE, Ohta K, Palkonen S, Papadopoulos NG, Passalacqua G, Pawankar R, Price D, Ryan D, Simons FE, Togias A, Williams D, Yorgancioglu A, Yusuf OM, Aberer W, Adachi M, Agache I, Aït-Khaled N, Akdis CA, Andrianarisoa A, Annesi-Maesano I, Ansotegui IJ, Baiardini I, Bateman ED, Bedbrook A, Beghé B, Beji M, Bel EH, Ben Kheder A, Bennoor KS, Bergmann KC, Berrissoul F, Bieber T, Bindslev Jensen C, Blaiss MS, Boner AL, Bouchard J, Braido F, Brightling CE, Bush A, Caballero F, Calderon MA, Calvo MA, Camargos PA, Caraballo LR, Carlsen KH, Carr W, Cepeda AM, Cesario A, Chavannes NH, Chen YZ, Chiriac AM, Chivato Pérez T, Chkhartishvili E, Ciprandi G, Costa DJ, Cox L, Custovic A, Dahl R, Darsow U, De Blay F, Deleanu D, Denburg JA, Devillier P, Didi T, Dokic D, Dolen WK, Douagui H, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, El-Meziane A, Emuzyte R, Fiocchi A, Fletcher M, Fukuda T, Gamkrelidze A, Gereda JE, González Diaz S, Gotua M, Guzmán MA, Hellings PW, Hellquist-Dahl B, Horak F, Hourihane JO, Howarth P, Humbert M, Ivancevich JC, Jackson C, Just J, Kalayci O, Kaliner MA, Kalyoncu AF, Keil T, Keith PK, Khayat G, Kim YY, Koffi N'goran B, Koppelman GH, Kowalski ML, Kull I, Kvedariene V, Larenas-Linnemann D, Le LT, Lemière C, Li J, Lieberman P, Lipworth B, Mahboub B, Makela MJ, Martin F, Marshall GD, Martinez FD, Masjedi MR, Maurer M, Mavale-Manuel S, Mazon A, Melen E, Meltzer EO, Mendez NH, Merk H, Mihaltan F, Mohammad Y, Morais-Almeida M, Muraro A, Nafti S, Namazova-Baranova L, Nekam K, Neou A, Niggemann B, Nizankowska-Mogilnicka E, Nyembue TD, Okamoto Y, Okubo K, Orru MP, Ouedraogo S, Ozdemir C, Panzner P, Pali-Schöll I, Park HS, Pigearias B, Pohl W, Popov TA, Postma DS, Potter P, Rabe KF, Ratomaharo J, Reitamo S, Ring J, Roberts R, Rogala B, Romano A, Roman Rodriguez M, Rosado-Pinto J, Rosenwasser L, Rottem M, Sanchez-Borges M, Scadding GK, Schmid-Grendelmeier P, Sheikh A, Sisul JC, Solé D, Sooronbaev T, Spicak V, Spranger O, Stein RT, Stoloff SW, Sunyer J, Szczeklik A, Todo-Bom A, Toskala E, Tremblay Y, Valenta R, Valero AL, Valeyre D, Valiulis A, Valovirta E, Van Cauwenberge P, Vandenplas O, van Weel C, Vichyanond P, Viegi G, Wang DY, Wickman M, Wöhrl S, Wright J, Yawn BP, Yiallouros PK, Zar HJ, Zernotti ME, Zhong N, Zidarn M, Zuberbier T, World Health Organization Collaborating Center for Asthma, and Rhinitis.
Published: 2012

17. Severe Chronic Allergic (and related) Diseases: a uniform approach- a MeDALL- GA(2)LEN-ARIA Position Paper

Author: WHO Collaborating Center for Asthma, Rhinitis, Bousquet, J, Anto, Jm, Demoly, P, Schünemann, Hj, Togias, A, Akdis, M, Auffray, C, Bachert, C, Bieber, T, Bousquet, Pj, Carlsen, Kh, Casale, Tb, Cruz, Aa, Keil, T, Lodrup Carlsen KC, Maurer, M, Ohta, K, Papadopoulos, Ng, Roman Rodriguez, M, Samolinski, B, Agache, I, Andrianarisoa, A, Ang, Cs, Annesi Maesano, I, Ballester, F, Baena Cagnani CE, Basagaña, X, Bateman, Ed, Bel, Eh, Bedbrook, A, Beghe', Bianca, Beji, M, Ben Kheder, A, Benet, M, Bennoor, Ks, Bergmann, Kc, Berrissoul, F, Bindslev Jensen, C, Bleecker, Er, Bonini, S, Boner, Al, Boulet, Lp, Brightling, Ce, Brozek, Jl, Bush, A, Busse, Ww, Camargos, Pa, Canonica, Gw, Carr, W, Cesario, A, Chen, Yz, Chiriac, Am, Costa, Dj, Cox, L, Custovic, A, Dahl, R, Darsow, U, Didi, T, Dolen, Wk, Douagui, H, Dubakiene, R, El Meziane, A, Fonseca, Ja, Fokkens, Wj, Fthenou, E, Gamkrelidze, A, Garcia Aymerich, J, Gerth van Wijk, R, Gimeno Santos, E, Guerra, S, Haahtela, T, Haddad, H, Hellings, Pw, Hellquist Dahl, B, Hohmann, C, Howarth, P, Hourihane, Jo, Humbert, M, Jacquemin, B, Just, J, Kalayci, O, Kaliner, Ma, Kauffmann, F, Kerkhof, M, Khayat, G, Koffi N'Goran, B, Kogevinas, M, Koppelman, Gh, Kowalski, Ml, Kull, I, Kuna, P, Larenas, D, Lavi, I, Le, Lt, Lieberman, P, Lipworth, B, Mahboub, B, Makela, Mj, Martin, F, Martinez, Fd, Marshall, Gd, Mazon, A, Melen, E, Meltzer, Eo, Mihaltan, F, Mohammad, Y, Mohammadi, A, Momas, I, Morais Almeida, M, Mullol, J, Muraro, A, Naclerio, R, Nafti, S, Namazova Baranova, L, Nawijn, Mc, Nyembue, Td, Oddie, S, O'Hehir, Re, Okamoto, Y, Orru, Mp, Ozdemir, C, Ouedraogo, Gs, Palkonen, S, Panzner, P, Passalacqua, G, Pawankar, R, Pigearias, B, Pin, I, Pinart, M, Pison, C, Popov, Ta, Porta, D, Postma, Ds, Price, D, Rabe, Kf, Ratomaharo, J, Reitamo, S, Rezagui, D, Ring, J, Roberts, R, Roca, J, Rogala, B, Romano, A, Rosado Pinto, J, Ryan, D, Sanchez Borges, M, Scadding, Gk, Sheikh, A, Simons, Fe, Siroux, V, Schmid Grendelmeier PD, Smit, Ha, Sooronbaev, T, Stein, Rt, Sterk, Pj, Sunyer, J, Terreehorst, I, Toskala, E, Tremblay, Y, Valenta, R, Valeyre, D, Vandenplas, O, van Weel, C, Vassilaki, M, Varraso, R, Viegi, G, Wang, Dy, Wickman, M, Williams, D, Wöhrl, S, Wright, J, Yorgancioglu, A, Yusuf, Om, Zar, Hj, Zernotti, Me, Zidarn, M, Zhong, N, Zuberbier, T., Beghe', B., Fthenou, E., Boudier, Anne, Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), IMIM-Hospital del Mar, Generalitat de Catalunya, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, CIBER Epidemiologia y Salud Publica, CIBER de Epidemiología y Salud Pública (CIBERESP), Universitat Pompeu Fabra [Barcelona] (UPF), WHO Collaborating Center for Asthma and Rhinitis, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Pharmacoepidemiologie et évaluation de l'impact des produits de santé sur les populations, Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Clinical Epidemiology and Biostatistics and Medicine, McMaster University [Hamilton, Ontario], National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Génomique fonctionnelle et biologie systémique pour la santé, Institut des Sciences Biologiques du CNRS, Upper Airway Research Laboratory (URL), Ghent University Hospital, Department of Dermatology and Allergy, VU University Medical Center [Amsterdam], Department of Paediatrics, University of Oslo (UiO)-Oslo University Hospital [Oslo], Division of Allergy and Immunology, Department of Medicine, Creighton University, ProAR - FMB, Federal University of Bahia School of Medicine, Epidemiology and Health Economics, Instittute of Social Health-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Dermatology, Medical School-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Division of Respiratory Medicine and Allergology, Teikyo University School of Medicine, Allergy Department, 2nd Pediatric Clinic, Son Pisa Primary Care Centre, IB-Salut Balearic Health Service, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Department of Allergy and Clinical Immunology, Faculty of Medicine-Transylvania University, Public Hospital Medical Service, Ministry of Health [Mozambique], Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Center for Public Health Research (CSISP), University of Valencia, Respiratory Medicine, Università degli studi di Genova = University of Genoa (UniGe)-School of Specialization, Faculty of Medicine, Catholic University, Health Sciences Faculty, University of Cape Town, Department of Pulmonology, University of Amsterdam [Amsterdam] (UvA)-Academic Medical Centre, Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton-School of Medicine, Service de Pneumologie Allergologie, Hôpital La Rabta [Tunis], Service de Pneumologie, Hôpital Abderrahmen Mami, National Asthma Centre, National Institute of Diseases of the Chest and Hospital (NIDCH), Pneumologie / Anesthésie - réanimation / Oxygénothérapie, Hôpital AKS Phnom Penh-Hôpital Provincial de Siemreap, Department of Dermatology and Allergy Center, Odense University Hospital, Center for Genomics and Personalized Medicine, Wake Forest University, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, Università degli studi di Verona = University of Verona (UNIVR), Institut de cardiologie et de pneumologie, Université Laval [Québec] (ULaval)-Centre Hospitalier de Laval (CH Laval), Department of Respiratory Medicine and Thoracic Surgery, University of Leicester-Institute for Lung Health, Department of Paediatric Respiratory Medicine, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute [UK], Department of Medicine, University of Wisconsin School of Medicine and Public Health, Department of Pediatrics, Universidade Federal de Minas Gerais [Belo Horizonte] (UFMG)-Medical School, Allergy & Respiratory Diseases, Università degli studi di Genova = University of Genoa (UniGe)-Department of Internal Medicine (DIMI), Allergy & Asthma Associates, University of California [Irvine] (UC Irvine), University of California (UC)-University of California (UC), Deputy Scientific Director, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana, Department of Thoracic Surgery, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), National Cooperative Group of Pediatric Research on Asthma, Asthma Clinic and Education Center of the Capital Institute of Pediatrics, Service des Premiers Soins, Université Montpellier 1 (UM1), Osteopathic College of Medicine, Nova Southeastern University (NSU), Respiratory Research Group, University of Manchester [Manchester]-School of Translational Medicine, Department of Respiratory Diseases, Aarhus University Hospital, Department of Dermatology and Allergy Biederstein, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Service de pneumologie, Centre hospitalier de la région d'Annecy, Service de pneumo-allergologie, Centre Hospitalo-Universitaire de Béni-Messous, Allergy Centre, Vilnius University Antakalnis Hospital, Société Marocaine des Maladies Respiratoires, Centre of Respiratory Diseases and Allergy-Centre commercial Nadia, Allergy Division, Hospital S. João-Centre for Research in Health Technologies and Information Systems (CINTESIS)-Biostatistics and Medical Informatics Department-Porto University Medical School, Department of Otorhinolaryngology, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA), Department of Social Medicine, University of Crete [Heraklion] (UOC)-Faculty of Medicine, Health Care, Minister Of Labour-Ministry of Labor, Health and Social Affairs, Section of Allergology, Erasmus Medical Centre, Epidemiology and Biostatistics Division, University of Arizona-Associate Research Scientist, Respiratory Sciences-Arizona Respiratory Center, Helsinki University Hospital-Skin and Allergy Hospital, Centre Hospitalier de Bigorre [Tarbes]-Association Franco-Libanaise de Pneumologie (AFLP), Department of Otorhinolaryngology, Head, and Neck Surgery, University Hospital Leuven, Engineering and the Environment, University of Southampton, Paediatrics and Child Health, University College Cork (UCC), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de l'Asthme et des Allergies [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Pediatric Allergy and Asthma Unit, Ihsan Dogramaci Children's Hospital-Hacettepe University School of Medicine, Institute for Asthma and Allergy, George Washington University Medical School, Department of Epidemiology, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Groningen Research Institute for Asthma and COPD (GRIAC), Université Saint-Joseph de Beyrouth (USJ)-Faculté de Médecine-Hôtel-Dieu de France, Service des Maladies Respiratoires, CHU de Cocody-UFR des Sciences Médicales, Pediatric Pulmonology, Allergology & Epidemiology, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD, Department of Clinical Immunology and Allergy, Medical University of Łódź (MUL)-Faculty ot Medicine, Centre for Allergy Research, Karolinska Institutet [Stockholm], Department of Clinical Science and Education, Division of Internal Medicine, Asthma and Allergy, Medical University of Łódź (MUL)-Barlicki University Hospital, Hospital Medica Sur, Physiology Department, University of Medicine and Pharmacy, Division of Allergy Immunology, Department of Medicine-The University of Tennessee Health Science Center [Memphis] (UTHSC), university of dundee asthma - allergic rhinitis - COPD - beta-2-adrenoceptor, University of Dundee, Pulmonary and allergy unit, American University of Sharjah-Rashid Hospital-Dubai Health Authority (DHA), Association Franco-Vietnamienne de Pneumologie (AFVP), Centre Hospitalier de Compiègne (CHC), Arizona Respiratory Center, Department of Medicine, Clinical Immunology and Allergy, University of Mississippi Medical Center (UMMC), Institute of Environmental Medicine, Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm]-Astrid Lindgren Children's Hospital, Allergy & Asthma Medical Group & Research Center, University of California [San Diego] (UC San Diego), Pneumology Department, Marius Nasta Institute of Pneumology, Department of Internal Medicine, Tishreen University School of Medicine, Association Franco-Marocaine de Pathologie Thoracique (AFMAPATH), Collège National des Pneumologues Marocains, Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Immunoallergy Department, Hospital CUF Descobertas, Rhinology Unit & Smell Clinic, Universitat de Barcelona (UB)-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Department of Medicine-Hospital Clinic-ENT Department, Allergy Unit, Università degli Studi di Padova = University of Padua (Unipd)-Department of Paediatrics, Section of Otolaryngology-Head & Neck Surgery (OHNS), University of Chicago, Clinique des maladies respiratoires, centre hospitalo-universitaire Mustapha Pacha d'Alger (CHUMA), Scientific Center for Children's Health, Russian Academy of Medical Sciences (RAMS), Laboratory of Allergology and Pulmonary Diseases, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Department of Pathology and Medical Biology-GRIAC Research Institute, ENT Department, University of Kinshasa (UNIKIN), Bradford Neonatology, Bradford Teaching Hospitals NHS Foundation Trust-Bradford Institute for Health Research, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Chiba University Hospital, Asthme Rhinite allergique, Pharmacie, Division of Pediatric Allergy and Immunology, marmara university, Pédiatrie, Centre Hospitalier National Pédiatrique Charles de Gaulle (CHNP-CDG), European Federation of Allergy (EFA), Airways Diseases Patients' Associations, Department of Allergology and Clinical Immunology, Charles University [Prague] (CU)-Medical Faculty in Pilsen, Immunopharmacology, Nippon Medical School-Medical Research Council Clinical, Laboratoire du Sommeil et de l'Effort, Société de Pneumologie de Langue Française (SPLF)-Clinique St George, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinic of Allergy and Asthma, Medical University Sofia-Alexander's University Hospital, Regional Health Service - Lazio, Primary Care Respiratory Medicine, University of Aberdeen-Department of General Practice and Primary Care-General Practice Airways Group (GPIAG), Department of Pulmonary Medicine, Leiden University Medical Center (LUMC), Pneumalgia, Centre Hospitalier Regional-Espace Francophone de Pneumologie (EFP)-Société de Pneumologie de l'Océan Indien (SPOI), Association Franco-Algérienne de Pneumologie (AFAP), Espace Francophone de pneumologie de la SPLF, Department of Pneumology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic de Barcelona-Institut Clínic del Tórax (ICT)-CIBER de Enfermedades Respiratorias (CIBERES)-University of Barcelona, Allergology and Clinical Immunology, Medical University of Silesia (SUM)-Chair and Clinical Department of Internal Diseases, UCSC-Allergy Unit, Complesso Integrato Columbus-Department of Internal Medicine and Geriatrics, Hospital da Luz, Medical Centre, Woodbrook Medical Centre, Research Fellow, University of Aberdeen-Department of General Practice, Centro Médico Docente La Trinidad, Department of Pharmacology, University College of London [London] (UCL)-The Royal National Throat, Nose and Ear Hospital, Primary Care Research & Development, University of Edinburgh-Centre for Population Health Sciences, Section of Allergy & Clinical Immunology, University of Manitoba [Winnipeg]-Department of Pediatrics & Child Health, Allergy Unit - Department of Dermatology, Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], National Centre of Cardiology and Internal Medicine, Ministry of Health Kyrgyz Republic, School of Medicine, Pontifícia Universidade Católica, Department of ENT and Pediatrics, Finnish Institute of Occupational Health, Department of Obstetrics and Gynaecology, Université Laval [Québec] (ULaval)-Faculty of Medicine, Christian Doppler Laboratory for Allergy Research, Medizinische Universität Wien = Medical University of Vienna-Division of Immunopathology-Department of Pathophysiology and Allergy Research-Center for Pathophysiology, Infectiology and Immunology, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Department of Chest Medicine, Mont-Godinne Hospital-Catholic University of Louvain de Mont-Godinne, Department of Primary and Community Care, Radboud University Medical Center [Nijmegen], Epidemiology Unit, National Research Council (CNR)-Institute of Biomedicine and Molecular Immunology (IBIM), Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Department of Otolaryngology, National University of Singapore (NUS)-Yong Loo Lin School of Medicine, Karolinska Institutet [Stockholm]-Sachs' Children's Hospital, GLP Analytical Facility, School of Pharmacy, Department of Dermatology Division of Immunology, Allergy and Infectious Diseases (DIAID), Medical University of Vienna (MUW), Celal Bayar University School of Medicine, Allergy and Asthma Clinics, The Allergy and Asthma Institute, Department of Paediatrics and Child Health, Respiratory and Allergic Diseases, University Clinic of Respiratory and Allergic Diseases Golnik, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases-Guangzhou Medical College, Secretary General of the Global Allergy and Asthma European Network (GA2LEN), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], In collaboration with the WHO Collaborating Center for Asthma and Rhinitis, University of Genoa (UNIGE)-School of Specialization, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, University of Verona (UNIVR), Medical School-Federal University of Minas Gerais, University of Genoa (UNIGE)-Department of Internal Medicine (DIMI), University of California [Irvine] (UCI), University of California-University of California, Catholic University Rome, University of Amsterdam [Amsterdam] (UvA)-Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Centre Hospitalier de Bigorre (Tarbes)-Association Franco-Libanaise de Pneumologie (AFLP), CUF-Descobertas Hospital, Universita degli Studi di Padova-Department of Paediatrics, Medical Faculty in Pilsen-Charles University in Prague - the First Faculty of Medicine, Centro Medico-Docente La Trinidad, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Instittute of Social Health, Department of Internal Medicine (DIMI)-University of Genoa (UNIGE), Medical University of Silesia-Chair and Clinical Department of Internal Diseases, Dermatology, Internal Medicine, Immunology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Center for Research in Environmental Epidemiology ( CREAL ), Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, Universitat Pompeu Fabra [Barcelona], WHO(OMS), Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), National Institute of Allergy and Infectious Diseases [Bethesda], National Institutes of Health ( NIH ), Swiss Institute of Allergy and Asthma Research ( SIAF ), University of Zürich [Zürich] ( UZH ), Upper Airway Research Laboratory ( URL ), University Medical Center, University of Oslo ( UiO ) -Oslo University Hospital, Charite-Universitatsmedizin Berlin [Berlin]-Instittute of Social Health, Medical School-Charité - University Medicine Berlin, Medical University of Warsaw-Faculté de Pharmacie de Paris, Ministry of Health, Epidémiologie des maladies infectieuses et modélisation ( ESIM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Center for Public Health Research ( CSISP ), University of Genoa ( UNIGE ) -School of Specialization, University of Amsterdam [Amsterdam] ( UvA ) -Academic Medical Centre, University of Southampton [Southampton]-School of Medicine, Hôpital La Rabta [Tunis), Wake Forest University Health Sciences, CNR, Rome, Italy and Department of Medicine-Second University of Naples, Università degli Studi di Verona, Université Laval-l'Hôpital Laval, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute, University of Genoa ( UNIGE ) -Department of Internal Medicine (DIMI), Southern California Research, Université Montpellier 1 ( UM1 ), Nova Southeastern University, Technische Universität München [München] ( TUM ), Academic Medical Center [Amsterdam] ( AMC ), University of Amsterdam [Amsterdam] ( UvA ) -University of Amsterdam [Amsterdam] ( UvA ), University of Crete ( UOC ) -Faculty of Medicine, University of Southampton [Southampton], UUniversity College Cork - National University of Ireland, Cork (UCC), Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Antoine Béclère, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Trousseau [APHP], University of Groningen [Groningen]-University Medical Center Groningen-Groningen Research Institute for Asthma and COPD (GRIAC), Université Saint-Joseph de Beyrouth ( USJ ) -Faculté de Médecine-Hôtel-Dieu de France, University of Groningen [Groningen]-University Medical Center Groningen-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD, Medical University of Łódź ( MUL ) -Faculty ot Medicine, Medical University of Łódź ( MUL ) -Barlicki University Hospital, Department of Medicine-University of Tennessee College for Medicine, Association Franco-Vietnamienne de Pneumologie ( AFVP ), University of Mississippi Medical Center, University of California [San Diego] ( UC San Diego ), Association Franco-Marocaine de Pathologie Thoracique ( AFMAPATH ), Epidémiologie Environnementale : Impact Sanitaire des Pollutions ( EA 4064 ), Université Paris Descartes - Paris 5 ( UPD5 ), Universitat de Barcelona ( UB ) -Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Department of Medicine-Hospital Clinic-ENT Department, Section of Otolaryngology-Head & Neck Surgery ( OHNS ), University of Groningen [Groningen]-University Medical Center Groningen-Department of Pathology and Medical Biology-GRIAC Research Institute, University Hospital of Kinshasa, European Federation of Allergy ( EFA ), Institut d'oncologie/développement Albert Bonniot de Grenoble ( INSERM U823 ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Bioenergétique fondamentale et appliquée ( LBFA ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Department of General Practice and Primary Care-General Practice Airways Group (GPIAG)-University of Aberdeen, Association Franco-Algérienne de Pneumologie ( AFAP ), Department of General Practice-University of Aberdeen, University College of London [London] ( UCL ) -The Royal National Throat, Nose and Ear Hospital, University Medical Center Utrecht, Faculty of Medicine-Laval University [Québec], Medical University of Vienna-Division of Immunopathology-Department of Pathophysiology and Allergy Research-Center for Pathophysiology, Infectiology and Immunology, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Avicenne, National University of Singapore ( NUS ) -Yong Loo Lin School of Medicine, Department of Dermatology Division of Immunology, Allergy and Infectious Diseases ( DIAID ), Secretary General of the Global Allergy and Asthma European Network ( GA2LEN ), Network of Excellence, Charité - Universitätsmedizin Berlin, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK (BIHR), Universiteit Leiden-Universiteit Leiden, and Medizinische Universität Wien = Medical University of Vienna
Subjects: MESH: Asthma, severity, MESH: Comorbidity, Comorbidity, Severity of Illness Index, urticaria, MESH : Chronic Disease, MESH: Practice Guidelines as Topic, MESH : Dermatitis, Atopic, MESH: Urticaria, risk, 216-31 [Rhinitis, atopy, allergen Int Arch Allergy Immunol. 2012,158(3)], atopic dermatitis, MESH : Rhinitis, MESH: Rhinitis, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Effective primary care and public health [NCEBP 7], Immunoglobulin E - Asthma - Rhinitis - Rhinosinusitis - Urticaria - Atopic dermatitis, MESH : Practice Guidelines as Topic, Practice Guidelines as Topic, MESH : Comorbidity, MESH : Severity of Illness Index, IgE, MESH: Sinusitis, MESH : Urticaria, MESH: Hypersensitivity, macromolecular substances, MESH : Asthma, Dermatitis, Atopic, rhinitis, SDG 3 - Good Health and Well-being, MESH: Dermatitis, Atopic, MESH: Severity of Illness Index, Hypersensitivity, Humans, Sinusitis, rhinosinusitis, MESH : Hypersensitivity, MESH: Humans, MESH: Chronic Disease, MESH : Humans, Asthma, Atopic dermatitis, Immunoglobulin E, Rhinitis, Rhinosinusitis, Urticaria, asthma, allergy, MESH : Sinusitis, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Chronic Disease, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, control
Abstract: Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies. Copyright (C) 2012 S. Karger AG, Basel
Published: 2012
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18. Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report

Author: Maurer, M, Weller, K, Bindslev Jensen, C, Giménez Arnau, A, Bousquet, Pj, Bousquet, J, Canonica, Giorgio, Church, Mk, Godse, Kv, Grattan, Ce, Greaves, Mw, Hide, M, Kalogeromitros, D, Kaplan, Ap, Saini, Ss, Zhu, Xj, and Zuberbier, T.
Published: 2011

19. GA² LEN/EAACI pocket guide for allergen-specific immunotherapy for allergic rhinitis and asthma

Author: Zuberbier, T, Bachert, C, Bousquet, Pj, Passalacqua, Giovanni, Canonica, Giorgio, Merk, H, Worm, M, Wahn, U, and Bousquet, J.
Published: 2010

20. Development and implementation of guidelines in allergic rhinitis an ARIA-GA2LEN paper

Author: Bousquet J, Schünemann HJ, Zuberbier T, Bachert C, Baena-Cagnani CE, Bousquet PJ, Brozek J, Canonica GW, Casale TB, Demoly P, Gerth van Wijk R, Ohta K, Bateman ED, Calderon M, Cruz AA, Dolen WK, Haughney J, Lockey RF, Lötvall J, O'Byrne P, Spranger O, and Tog
Subjects: rhinitis, asthma
Abstract: The links between asthma and rhinitis are well characterized. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines stress the importance of these links and provide guidance for their prevention and treatment. Despite effective treatments being available, too few patients receive appropriate medical care for both diseases. Most patients with rhinitis and asthma consult primary care physicians and therefore these physicians are encouraged to understand and use ARIA guidelines. Patients should also be informed about these guidelines to raise their awareness of optimal care and increase control of the two related diseases. To apply these guidelines, clinicians and patients need to understand how and why the recommendations were made. The goal of the ARIA guidelines is to provide recommendations about the best management options for most patients in most situations. These recommendations should be based on the best available evidence. Making recommendations requires the assessment of the quality of available evidence, deciding on the balance between benefits and downsides, consideration of patients values and preferences, and, if applicable, resource implications. Guidelines must be updated as new management options become available or important new evidence emerges. Transparent reporting of guidelines facilitates understanding and acceptance, but implementation strategies need to be improved.
Published: 2010

21. Efficacy of desloratadine in persistent allergic rhinitis - a GA²LEN study

Author: Bousquet, J, Bachert, C, Canonica, Gw, Mullol, J, Van Cauwenberge, P, Jensen, Cb, Fokkens, Wj, Ring, J, Keith, P, Gopalan, G, Lorber, R, Zuberbier, T, 2 Study Group: Antepara I, Accept, Bálint, B, Barbosa, M, Bindslev Jensen, C, Blanco, C, Bousquet, Pj, Campos, Á, Camps, Pj, Castel Branco, G, Cheema, A, Chieira, C, Chivato, T, Cirillo, A, Daikhes, N, del Carpio, J, di Lorenzo, G, Erisen, L, Farouz, Jc, Fokkens, W, Gambarelli, J, Gering, R, Goryachkina, L, Guilherme, A, Hébert, J, Ilyina, N, Jääskeläinen, T, Joki Erkkila VP, Kalogermitros, D, Karci, B, Kasche, D, Klimek, L, Knight, A, Koistinen, T, Külahi, I, Lebeaupin, B, Lindskog, T, Lopatin, A, Magyar, P, Malek, T, Manconi, P, Meischner, K, Merk, H, Morete, A, Moscato, G, Mösges, R, Önerci, M, Ortolan, D, Pasch, N, Pastorello, Ea, Penttila, M, Pucci, S, Quercia, O, Rantaiso, E, Rinne, J, Roger, A, Rolla, Giovanni, Romano, A, Romberg, K, Rouanet Bousquet, L, Ryazantsev, S, Salo, S, Sancinena, O, Sanquer, F, Sauvan Pistof, C, Sidiropoulos, I, Sidorenko, I, Sussman, G, Szalai, Z, Szilasi, M, Tilling, B, Tosoni, C, Troise, C, Tutkun, A, Vacca, A, Vinge, I, Vourdas, D, Wessel, F, Yang, W, and Zuberbier, T.
Subjects: Adult, Male, Histamine H1 Antagonists, Non-Sedating, allergic rhinitis, Rhinitis, Allergic, Perennial, desloratadine, Rhinitis, Allergic, Seasonal, Loratadine, Middle Aged, Severity of Illness Index, anti histamine drugs, Disease Progression, Quality of Life, Humans, Female, Follow-Up Studies, Pain Measurement
Abstract: The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines proposed a classification for allergic rhinitis based on the duration of symptoms (intermittent or persistent) rather than on the time of allergen exposure (seasonal or perennial). There had been no placebo-controlled, randomized, clinical trial of desloratadine (DL) in patients with persistent allergic rhinitis to date.To assess the efficacy and safety of DL in patients with persistent allergic rhinitis based on the ARIA classification.Patients 12 years of age and older with persistent allergic rhinitis were assessed over 85 days of treatment with DL 5 mg once daily (n = 360) or placebo (n = 356). The primary endpoint was the AM/PM reflective total 5-symptom score (T5SS) averaged over days 1-29. Secondary endpoints included AM/PM instantaneous T5SS and individual symptoms, therapeutic response, symptom severity assessed by a visual analogue scale and quality of life.The mean reduction in AM/PM reflective T5SS was significantly greater with DL than placebo over days 1-29 (-3.76 vs. -2.87, p0.001) and on each individual day (p0.05). The mean AM instantaneous T5SS was significantly reduced with DL compared with placebo as early as day 2 (-1.90 vs. -1.46; p0.001). The therapeutic response and improvement in quality of life were significantly greater with DL than placebo (p0.001 for each). The frequency of treatment-related adverse events was low and similar between DL (10.0%) and placebo (8.4%).This study showed DL to be effective and safe in the treatment of persistent allergic rhinitis.
Published: 2009

22. Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project

Author: Bousquet, Pj, Demoly, P, Romano, A, Aberer, W, Bircher, A, Blanca, M, Brockow, K, Pichler, W, Torres, Mj, Terreehorst, I, Arnoux, B, Atanaskovic Markovic, M, Barbaud, A, Bijl, A, Bonadonna, P, Burney, Pg, Caimmi, S, Canonica, Giorgio, Cernadas, J, Dahlen, B, Daures, Jp, Fernandez, J, Gomes, E, Gueant, Jl, Kowalski, Ml, Kvedariene, V, Mertes, Pm, Martins, P, Nizankowska Mogilnicka, E, Papadopoulos, N, Ponvert, C, Pirmohamed, M, Ring, J, Salapatas, M, Sanz, Ml, Szczeklik, A, Van Ganse, E, De Weck AL, Zuberbier, T, Merk, Hf, Sachs, B, Sidoroff, A, Global Allergy Asthma European Network, Drug, Allergy, Hypersensitivity, Database, and the European Network for Drug Allergy
Published: 2009

23. Sub-lingual immunotherapy

Author: Bousquet, PJ, Cox, LS, Durham, SR, Nelson, HS, Passalacqua, G, Ryan, DP, Brozek, JL, Compalati, E, Dahl, R, Delgado, L, Gerth van Wijk, Roy, Gower, RG, Ledford, DK, Filho, NR, Valovirta, E, Yusuf, OM, Zuberbier, T, Plastic and Reconstructive Surgery and Hand Surgery, and Internal Medicine
Published: 2009

24. Recommendations for standardization of clinical trials with Allergen Specific Immunotherapy for respiratory allergy. A statement of a World Allergy Organization (WAO) taskforce

Author: Canonica, Giorgio, BAENA CAGNANI CE, Bousquet, J, Bousquet, Pj, Lockey, Rf, Malling, Hj, Passalacqua, Giovanni, Potter, P, and Valovirta, E.
Published: 2007

25. ARIA Update I: complementary and alternative medicines

Author: Passalacqua, Giovanni, Bousquet, Pj, Carlsen, Kh, Lockey, Rf, Kemp, J, Pawankar, R, Price, D, and Bousquet, J.
Published: 2006

26. Asthma in adults and its association with chronic rhinosinusitis : the GA(2) LEN survey in Europe

Author: Jarvis, D, Newson, R, Lotvall, J, Hastan, D, Tomassen, P, Keil, T, Gjomarkaj, M, Forsberg, Bertil, Gunnbjornsdottir, M, Minov, J, Brozek, G, Dahlen, SE, Toskala, E, Kowalski, ML, Olze, H, Howarth, P, Krämer, U, Baelum, J, Loureiro, C, Kasper, L, Bousquet, PJ, Bousquet, J, Bachert, C, Fokkens, W, Burney, P, Jarvis, D, Newson, R, Lotvall, J, Hastan, D, Tomassen, P, Keil, T, Gjomarkaj, M, Forsberg, Bertil, Gunnbjornsdottir, M, Minov, J, Brozek, G, Dahlen, SE, Toskala, E, Kowalski, ML, Olze, H, Howarth, P, Krämer, U, Baelum, J, Loureiro, C, Kasper, L, Bousquet, PJ, Bousquet, J, Bachert, C, Fokkens, W, and Burney, P
Abstract: Background: The prevalence of asthma and its association with chronic rhinosinusitis (CRS) have not been widely studied in population-based epidemiological surveys. Methods: The Global Allergy and Asthma Network of Excellence (GA2LEN) conducted a postal questionnaire in representative samples of adults living in Europe to assess the presence of asthma and CRS defined by the European Position Paper on Rhinosinusitis and Nasal Polyps. The prevalence of self-reported current asthma by age group was determined. The association of asthma with CRS in each participating centre was assessed using logistic regression analyses, controlling for age, sex and smoking, and the effect estimates were combined using standard methods of meta-analysis. Results: Over 52 000 adults aged 18–75 years and living in 19 centres in 12 countries took part. In most centres, and overall, the reported prevalence of asthma was lower in older adults (adjusted OR for 65–74 years compared with 15–24 years: 0.72; 95% CI: 0.63–0.81). In all centres, there was a strong association of asthma with CRS (adjusted OR: 3.47; 95% CI: 3.20–3.76) at all ages. The association with asthma was stronger in those reporting both CRS and allergic rhinitis (adjusted OR: 11.85; 95% CI: 10.57–13.17). CRS in the absence of nasal allergies was positively associated with late-onset asthma. Conclusion: Geographical variation in the prevalence of self-reported asthma was observed across Europe, but overall, self-reported asthma was more common in young adults, women and smokers. In all age groups, men and women, and irrespective of smoking behaviour, asthma was also associated with CRS.
Published: 2012
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27. Heterogeneous assessment of shoulder disorders: Validation of the Standardized Index of Shoulder Function

Author: Dupeyron, A, primary, Gelis, A, additional, Sablayrolles, P, additional, Bousquet, PJ, additional, Julia, M, additional, Herisson, C, additional, Pélissier, J, additional, and Codine, P, additional
Published: 2010
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28. An increase in aortic blood flow after an infusion of 100 ml colloid over 1 minute can predict fluid responsiveness: the mini-fluid challenge study.

Author: Muller L, Toumi M, Bousquet PJ, Riu-Poulenc B, Louart G, Candela D, Zoric L, Suehs C, de La Coussaye JE, Molinari N, Lefrant JY, and AzuRéa Group
Published: 2011
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29. Assessment of allergen sensitization in a general population-based survey (European community respiratory health survey I)

Author: Bousquet PJ, Castelli C, Daures JP, Heinrich J, Hooper R, Sunyer J, Wjst M, Jarvis D, and Burney P
Abstract: PURPOSE: Exposed to a common environment, the IgE-mediated immune response differs, for instance, among sensitized subjects, some of them reacting toward one allergen (monosensitized) whereas others are sensitized to a wide array of allergens (polysensitized). However, a better phenotypic characterization is needed for epidemiologic studies. Using the data collected during the ECRHS I (European Community Respiratory Health Survey), several assessments of skin prick tests and serum-specific IgE to identify mono- and polysensitized patients were compared. METHODS: Subjects took part in the ECRHS-I. The CAP-System was used for serum allergen-specific IgE, and allergen-coated Phazet was used for prick tests. Four allergens (Dermatophagoides pteronyssinus, cat, timothy grass, and Cladosporium) were measured using IgE and nine (the same ones plus olive pollen, birch, Alternaria, Parietaria, and ragweed) were skin tested. One to two local allergens were also tested, depending on countries. RESULTS: Prevalence of sensitization in 11,355 subjects (34.0 [27.9-40.1] years, 49.9% men) ranged from 32.3% (four specific IgE, 19.3% mono- and 13.0% polysensitized) to 41.8% (four specific IgE combined to nine prick tests, 19.6% mono- and 22.2% polysensitized). Concordance between four specific IgE and four prick tests was weak (weighted [kappa] 0.65 [0.64-0.66]). Concordance between seven and nine prick tests was high (weighted [kappa] 0.99 [0.98-1.00]). Local allergens induced small changes in the prevalence of sensitization, and reclassified some subjects from mono- to polysensitized. CONCLUSIONS: Skin tests or serum-specific IgE may be chosen to identify allergenic sensitivity, mono- and polysensitized subjects without being strictly interchangeable. [ABSTRACT FROM AUTHOR]
Published: 2010
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30. Operational Definition of Active and Healthy Aging (AHA): The European Innovation Partnership (EIP) on AHA Reference Site Questionnaire: Montpellier October 20-21, 2014, Lisbon July 2, 2015

Author: Karen Ritchie, Daniel Harman, Philippe-Jean Bousquet, Erik Melén, Pierre Senesse, Govert Joan Buijs, Antonio Cano, Claude Jeandel, Timo E. Strandberg, Marieke Van Beurden, Pascal Demoly, G. Moda, Raquel Santiago, Sylvie Arnavielhe, Marie-Eve Joel, Nicola Wilson, Eveline Wouters, Jacques Touchon, Martina O'Neill, Isabelle Momas, Karen Andersen Ranberg, D. Heve, Maddalena Illario, Christina Tischer, Jean Bousquet, Marcel Goldberg, Paola Bertone, Guido Iaccarino, Antoine Avignon, Rodolphe Bourret, Valeria Romano, Laura Calzà, Henriet A. Smit, Mirca Barbolini, David Kula, Jacques-Yves Pelissier, Mario Barbagallo, Bruno Vellas, Ann Scott, C. Robalo-Cordeiro, Gregoire Mercier, Mike Bewick, Bernard Combe, Holger Schulz, Sergio Bonini, P. Viriot-Durandal, Itziar Vergara, M. Nogues, Carol Brayne, João Apóstolo, Jacques Mercier, Vicente Traver-Salcedo, François Puisieux, Julia Coletta, Alessandro Blasimme, Olivier Krys, Niels H. Chavannes, John Farrell, Joël Ankri, Ana Maria Carriazo, Rafaelle Varraso, Marie Zins, Zdenec Gutter, José António Pereira da Silva, Bertrand Fougère, Frédéric Cuisinier, Bolesław Samoliński, Jacques Bringer, Theodore D. Cosco, Jordi Alonso, Ana Todo-Bom, Claudine Berr, Daniel Laune, Esteban De Manuel Keenoy, Judith Garcia-Aymerich, Anna Bedbrook, Anne Hendry, Richard Pengelly, Dagmar Poethig, João O. Malva, Thomas Keil, Sandra N. Slagter, Nick A. Guldemond, Pierre Matignon, Hubert Blain, Leocadio Rodríguez Mañas, Marek L. Kowalski, Susana Fernandez-Nocelo, Alfredo Cesario, Sandra Rebello, Federico Alonso, Catarina R. Oliveira, Dieter Maier, Jean-Pierre Michel, David Somekh, T. Camuzat, Julien Venne, Marc Criton, Jaime Correia de Sousa, Hassan Arshad, Anabella Mota Pinto, Valentina A. Andreeva, François Roubille, Yoav Ben-Shlomo, Asghar Zaidi, Elena Villalba-Mora, Emmanuelle Kesse-Guyot, Dirkje S. Postma, Carel Thijs, Jean-Marie Robine, Danielle Porta, George Crooks, Adrianna Nizinska, Jorge Suanzes, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Bone and Joint Research Group, University of Southampton Medical School, CHU Toulouse [Toulouse], Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Social Medicine, University of Bristol [Bristol], Pathologies du système nerveux : recherche épidémiologique et clinique, Université Montpellier 1 (UM1)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Electrical Engineering, Mathematics and Computer Science [Delft], Delft University of Technology (TU Delft), Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), F2ME, PSA Peugeot - Citroën (PSA), PSA Peugeot Citroën (PSA)-PSA Peugeot Citroën (PSA)-Laboratoire Pluridisciplinaire de Recherche en Ingénierie des Systèmes, Mécanique et Energétique (PRISME), Université d'Orléans (UO)-Ecole Nationale Supérieure d'Ingénieurs de Bourges (ENSI Bourges)-Université d'Orléans (UO)-Ecole Nationale Supérieure d'Ingénieurs de Bourges (ENSI Bourges), Department of Epidemiology and Public Health, Imperial College London, CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-École des hautes études en sciences sociales (EHESS), Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Department of Prevention of Envinronmental Hazards and Allergology, Medical University of Warsaw - Poland, Department of Epidemiology, Maastricht University [Maastricht]-School for Public Health and Primary Care (CAPHRI), Hôpital Gui de Chauliac, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Kyomed, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Department of Geriatrics - Efficiency and Deficiency Laboratory, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Consiglio Nazionale delle Ricerche (CNR), Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Department of Public Health and Primary Care, University of Cambridge [UK] (CAM), Service d'endocrinologie, Departamento de Sistemas Informáticos y Computación [Valencia], Universitat Politècnica de València (UPV), Deputy Scientific Director, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana, Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Laboratoire de chimie biomoléculaire (LCB), Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-MAYOLI SPINDLER SA-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Bioingénierie et NanoSciences (LBN), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Laboratoire de Gérontechnologie [Hôpital La Grave-CHU de Toulouse], Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Gérontopôle, IMIM-Hospital del Mar, Generalitat de Catalunya, Département de Biostatistiques, Agence Régionale de Santé Languedoc Roussillon (ARS), Department of Medicine and Surgery, Università degli Studi di Salerno (UNISA)-RCCS 'Multimedia', Centre de gérontologie clinique, Institute of Social Medicine, Epidemiology and Health Economics-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institute of Environmental Medicine, Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm]-Astrid Lindgren Children's Hospital, Lab-STICC_TB_CID_TOMS, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Universidad Pública de Navarra [Espagne] = Public University of Navarra (UPNA), Unité de Virologie clinique et fondamentale (UVCF), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Mécanismes adaptatifs : des organismes aux communautés (MAOAC), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Department of Pulmonary Medicine and Tuberculosis, University of Groningen [Groningen], Service de gériatrie, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Allergy and Clinical Immunology Department, Hospitais da Universidade de Coimbra, Département de nutrition et d'oncologie digestive, CRLCC Val d'Aurelle - Paul Lamarque, Institute of Epidemiology [Neuherberg] (EPI), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Bousquet, Jean, Malva, Joao, Nogues, Michel, Mañas, Leocadio Rodriguez, Vellas, Bruno, Farrell, J, Bewick, M, Kowalski, Ml, Strandberg, T, Alonso, J, Ranberg, Ka, Ankri, J, Barbagallo, M, Ben Shlomo, Y, Berr, C, Crooks, G, de Manuel Keenoy, E, Goldberg, M, Guldemond, N, Illario, Maddalena, Joel, Me, Kesse Guyot, E, Michel, Jp, Pengelly, R, Ritchie, K, Robine, Jm, Romano, V, Samolinski, B, Schulz, H, Thijs, C, Touchon, J, Zaidi, A, Apostolo, J, Alonso, F, Andreeva, V, Arnavielhe, S, Arshad, H, Avignon, A, Barbolini, M, Bedbrook, A, Bertone, P, Blain, H, Blasimme, A, Bonini, S, Bourret, R, Bousquet, Pj, Brayne, C, Bringer, J, Buijs, Gj, Calza, L, Camuzat, T, Cano, A, Carriazo, A, Cesario, A, Chavannes, N, Combe, B, Coletta, J, de Sousa, Jc, Cosco, T, Criton, M, Cuisinier, F, Demoly, P, Fernandez Nocelo, S, Fougère, B, Garcia Aymerich, J, Gutter, Z, Harman, D, Hendry, A, Hève, D, Iaccarino, G, Jeandel, C, Keil, T, Krys, O, Kula, D, Laune, D, Maier, D, Matignon, P, Melen, E, Mercier, G, Moda, G, Momas, I, Pinto, Am, Nizinska, A, Oliveira, C, O'Neill, M, Pelissier, Jy, Pereira da Silva, Ja, Poethig, D, Porta, D, Postma, D, Puisieux, F, Rebello, S, Robalo Cordeiro, C, Roubille, F, Santiago, R, Scott, A, Senesse, P, Slagter, S, Smit, Ha, Somekh, D, Suanzes, J, Tischer, C, Todo Bom, A, Traver Salcedo, V, Van Beurden, M, Varraso, R, Venne, J, Vergara, I, Villalba Mora, E, Viriot Durandal, P, Wilson, N, Wouters, E, Zins, M, Mercier, J., Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, Université Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National de la Recherche Agronomique (INRA), Ecole Nationale Supérieure d'Ingénieurs de Bourges (ENSI Bourges)-Université d'Orléans (UO)-Ecole Nationale Supérieure d'Ingénieurs de Bourges (ENSI Bourges)-Université d'Orléans (UO), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CHU Montpellier, Universidad Politécnica de Valencia, Centre National de la Recherche Scientifique (CNRS)-MAYOLI SPINDLER SA-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Gérontopôle-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse], University of Salerno (UNISA)-RCCS 'Multimedia', Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin -Epidemiology and Health Economics, Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Universidad Pública de Navarra [Espagne] (UPNA), Unité de Virologie clinique et fondamentale EA 4294, Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF)-Muséum national d'Histoire naturelle (MNHN), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Bousquet J, Malva J, Nogues M, Mañas LR, Vellas B, Farrell J, MACVIA Research Group [.., L. Calzà, ], Farrell, John, Bonini, Sergio, Université Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Muséum national d'Histoire naturelle (MNHN)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, and RS: CAPHRI - R5 - Optimising Patient Care
Subjects: Gerontology, Concept Formation, [SDV]Life Sciences [q-bio], Disability Evaluation, 0302 clinical medicine, SF-12, QUALITY-OF-LIFE, Surveys and Questionnaires, WHODAS 2.0, Medicine, 030212 general & internal medicine, VERSION, POPULATION, PSYCHOLOGICAL DISTRESS, SCALE, General Nursing, Nursing (all)2901 Nursing (miscellaneous), health care economics and organizations, ComputingMilieux_MISCELLANEOUS, Aged, 80 and over, education.field_of_study, Operational definition, Medicine (all), Health Policy, PHYSICAL-ACTIVITY QUESTIONNAIRE, PRIMARY-CARE, General Medicine, 3. Good health, Europe, General partnership, Scale (social sciences), Population, SELF-REPORT, VALIDATION, 03 medical and health sciences, Quality of life (healthcare), EQ-5D, Journal Article, Humans, OLDER-ADULTS, education, Geriatric Assessment, Health policy, Aged, business.industry, questionnaire, Active and healthy ageing, United States, Questionnaire, Quality of Life, The Conceptual Framework, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: A core operational definition of active and healthy aging (AHA) is needed to conduct comparisons. A conceptual AHA framework proposed by the European Innovation Partnership on Active and Healthy Ageing Reference Site Network includes several items such as functioning (individual capability and underlying body systems), well-being, activities and participation, and diseases (including non-communicable diseases, frailty, mental and oral health disorders). The instruments proposed to assess the conceptual framework of AHA have common applicability and availability attributes. The approach includes core and optional domains/instruments depending on the needs and the questions. A major common domain is function, as measured by the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0). WHODAS 2.0 can be used across all diseases and healthy individuals. It covers many of the AHA dimensions proposed by the Reference Site network. However, WHODAS 2.0 does not include all dimensions proposed for AHA assessment. The second common domain is health-related quality of life (HRQoL). A report of the AHA questionnaire in the form of a spider net has been proposed to facilitate usual comparisons across individuals and groups of interest. (C) 2015 Published by Elsevier Inc. on behalf of AMDA - The Society for Post-Acute and Long-Term Care Medicine.
Published: 2015
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31. GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe

Author: Heinzerling, L M, Burbach, G J, Edenharter, G, Bachert, C, Bindslev-Jensen, C, Bonini, S, Bousquet, J, Bousquet-Rouanet, L, Bousquet, P J, Bresciani, M, Bruno, A, Burney, P, Canonica, G W, Darsow, U, Demoly, P, Durham, S, Fokkens, W J, Giavi, S, Gjomarkaj, M, Gramiccioni, C, Haahtela, T, Kowalski, M L, Magyar, P, Muraközi, G, Orosz, M, Papadopoulos, N G, Röhnelt, C, Stingl, G, Todo-Bom, A, von Mutius, E, Wiesner, A, Wöhrl, S, Zuberbier, T, AII - Amsterdam institute for Infection and Immunity, Ear, Nose and Throat, Heinzerling, Lm, Burbach, Gj, Edenharter, G, Bachert, C, BINDSLEV JENSEN, C, Bonini, Sergio, Bousquet, J, BOUSQUET ROUANET, L, Bousquet, Pj, Bresciani, M, Bruno, A, Burney, P, Canonica, Gw, Darsow, U, Demoly, P, Durham, S, Fokkens, Wj, Giavi, S, Gjomarkaj, M, Gramiccioni, C, Haahtela, T, Kowalski, Ml, Magyar, P, Muraközi, G, Orosz, M, Papadopoulos, Ng, Röhnelt, C, Stingl, G, TODO BOM, A, VON MUTIUS, E, Wiesner, A, Wöhrl, S, Zuberbier, T., and University of Zurich
Subjects: Adult, Hypersensitivity, Immediate, Male, Adolescent, 610 Medicine & health, Dermatitis, Atopic, Young Adult, Dogs, immune system diseases, Administration, Inhalation, Animals, Humans, Aged, Rhinitis, Skin Tests, 2403 Immunology, Allergens, Middle Aged, Asthma, respiratory tract diseases, Europe, 10036 Medical Clinic, Population Surveillance, 2723 Immunology and Allergy, Cats, Female, Food Hypersensitivity
Abstract: Udgivelsesdato: 2009-Oct BACKGROUND: Skin prick testing is the standard for diagnosing IgE-mediated allergies. However, different allergen extracts and different testing procedures have been applied by European allergy centres. Thus, it has been difficult to compare results from different centres or studies across Europe. It was, therefore, crucial to standardize and harmonize procedures in allergy diagnosis and treatment within Europe. AIMS: The Global Asthma and Allergy European Network (GA(2)LEN), with partners and collaborating centres across Europe, was in a unique position to take on this task. The current study is the first approach to implement a standardized procedure for skin prick testing in allergies against inhalant allergens with a standardized pan-European allergen panel. METHODS: The study population consisted of patients who were referred to one of the 17 participating centres in 14 European countries (n = 3034, median age = 33 years). Skin prick testing and evaluation was performed with the same 18 allergens in a standardized procedure across all centres. RESULTS: The study clearly shows that many allergens previously regarded as untypical for some regions in Europe have been underestimated. This could partly be related to changes in mobility of patients, vegetation or climate in Europe. CONCLUSION: The results of this large pan-European study demonstrate for the first time sensitization patterns for different inhalant allergens in patients across Europe. The standardized skin prick test with the standardized allergen battery should be recommended for clinical use and research. Further EU-wide monitoring of sensitization patterns is urgently needed.
Published: 2009
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32. GA(2)LEN SKIN TEST STUDY II: CLINICAL RELEVANCE OF INHALANT ALLERGEN SENSITIZATIONS IN EUROPE

Author: A Wiesner, L. Bousquet-Rouanet, G Edenharter, T. Zuberbier, C Rohnelt, Stavroula Giavi, Mark Gjomarkaj, E. von Mutius, W. J. Fokkens, Stephen R. Durham, Philippe-Jean Bousquet, G Murakozi, Andreina Bruno, Jean Bousquet, Ana Todo-Bom, GJ Burbach, Georg Stingl, C. Gramiccioni, G.W. Canonica, Marek L. Kowalski, Claus Bachert, P Magyar, Pascal Demoly, Ulf Darsow, M Orosz, M. Bresciani, Sergio Bonini, Tari Haahtela, Carsten Bindslev-Jensen, Stefan Wöhrl, Nikolaos G. Papadopoulos, L. Heinzerling, Burbach, Gj, Heinzerling, Lm, Edenharter, G, Bachert, C, BINDSLEV JENSEN, C, Bonini, Sergio, Bousquet, J, BOUSQUET ROUANET, L, Bousquet, Pj, Bresciani, M, Bruno, A, Canonica, Gw, Darsow, U, Demoly, P, Durham, S, Fokkens, Wj, Giavi, S, Gjomarkaj, M, Gramiccioni, C, Haahtela, T, Kowalski, Ml, Magyar, P, Muraközi, G, Orosz, M, Papadopoulos, Ng, Röhnelt, C, Stingl, G, TODO BOM, A, VON MUTIUS, E, Wiesner, A, Wöhrl, S, Zuberbier, T., AII - Amsterdam institute for Infection and Immunity, Ear, Nose and Throat, University of Zurich, and Zuberbier, T
Subjects: Adult, Hypersensitivity, Immediate, medicine.medical_specialty, Allergy, Immunology, Population, 610 Medicine & health, Poaceae, Atopy, Dogs, Food allergy, Hypersensitivity, Immunology and Allergy, Medicine, Animals, Humans, Clinical significance, Medical history, education, Asthma, Plant Proteins, Skin Tests, education.field_of_study, 2403 Immunology, Inhalation Exposure, business.industry, Atopic dermatitis, Allergens, medicine.disease, Dermatology, Europe, 10036 Medical Clinic, 2723 Immunology and Allergy, Cats, business
Abstract: Udgivelsesdato: 2009-Oct BACKGROUND: Skin prick testing is the standard for diagnosing IgE-mediated allergies. A positive skin prick reaction, however, does not always correlate with clinical symptoms. A large database from a Global Asthma and Allergy European Network (GA(2)LEN) study with data on clinical relevance was used to determine the clinical relevance of sensitizations against the 18 most frequent inhalant allergens in Europe. The study population consisted of patients referred to one of the 17 allergy centres in 14 European countries (n = 3034, median age = 33 years). The aim of the study was to assess the clinical relevance of positive skin prick test reactions against inhalant allergens considering the predominating type of symptoms in a pan-European population of patients presenting with suspected allergic disease. METHODS: Clinical relevance of skin prick tests was recorded with regard to patient history and optional additional tests. A putative correlation between sensitization and allergic disease was assessed using logistic regression analysis. RESULTS: While an overall rate of >or=60% clinically relevant sensitizations was observed in all countries, a differential distribution of clinically relevant sensitizations was demonstrated depending on type of allergen and country where the prick test was performed. Furthermore, a significant correlation between the presence of allergic disease and the number of sensitizations was demonstrated. CONCLUSION: This study strongly emphasizes the importance of evaluating the clinical relevance of positive skin prick tests and calls for further studies, which may, ultimately, help increase the positive predictive value of allergy testing.
Published: 2009
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33. The CONSORT statement checklist in allergen-specific immunotherapy: a GA2LEN paper

Author: P J, Bousquet, J, Brozek, C, Bachert, T, Bieber, S, Bonini, P, Burney, M, Calderon, G W, Canonica, E, Compalati, J P, Daures, L, Delgado, P, Demoly, R, Dahl, S R, Durham, M L, Kowalski, H J, Malling, H, Merk, N, Papadopoulos, G, Passalacqua, H U, Simon, M, Worms, U, Wahn, T, Zuberbier, H J, Schünemann, J, Bousquet, Bousquet, Pj, Brozek, J, Bachert, C, Bieber, T, Bonini, Sergio, Burney, P, Calderon, M, Canonica, Gw, Compalati, E, Daures, Jp, Delgado, L, Demoly, P, Dahl, R, Durham, Sr, Kowalski, Ml, Malling, Hj, Merk, H, Papadopoulos, N, Passalacqua, G, Simon, Hu, Worms, M, Wahn, U, Zuberbier, T, Schünemann, Hj, and Bousquet, J.
Subjects: Double-Blind Method, Patient Selection, Humans, Immunotherapy, Allergens, Reference Standards, Randomized Controlled Trials as Topic
Abstract: Udgivelsesdato: 2009-Dec The methodology of randomized clinical trials is essential for the critical assessment and registration of therapeutic interventions. The CONSORT (Consolidated Standards of Reporting Trials) statement was developed to alleviate the problems arising from the inadequate reporting of randomized controlled trials. The present article reflects on the items that we believe should be included in the CONSORT checklist in the context of conducting and reporting trials in allergen-specific immunotherapy. Only randomized, blinded (in particular blinding of patients, health care providers, and outcome assessors), placebo-controlled Phase III studies in this article. Our analysis focuses on the definition of patients' inclusion and exclusion criteria, allergen standardization, primary, secondary and exploratory outcomes, reporting of adverse events and analysis.
Published: 2009
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34. GA(2)LEN (Global Allergy and Asthma European Network) addresses the allergy and asthma 'epidemic'

Author: Peter H. Howarth, Ewa Nizankowska-Mogilnicka, Holger J. Schünemann, A Szczecklik, Marek L. Kowalski, Philippe-Jean Bousquet, Peter Burney, Katja Radon, N Auvergne, Erkka Valovirta, G. Lenzen, Nikolaos G. Papadopoulos, Paul Van Cauwenberge, M. Salapatas, Bert Brunekreef, Mark Gjomarkaj, Josep M. Antó, Tari Haahtela, T. Zuberbier, G.W. Canonica, J. Ring, Ana Todo-Bom, Jan Lötvall, Elina Toskala, Karin C. Lødrup-Carlsen, Cezmi A. Akdis, Claus Bachert, J Mullol, W. J. Fokkens, Francine Kauffmann, J P Zock, K-H. Carlsen, Jean Bousquet, Magnus Wickman, Sergio Bonini, Carsten Bindslev-Jensen, E. von Mutius, AII - Amsterdam institute for Infection and Immunity, Ear, Nose and Throat, Bousquet, J, Burney, Pg, Zuberbier, T, Cauwenberge, Pv, Akdis, Ca, BINDSLEV JENSEN, C, Bonini, Sergio, Fokkens, Wj, Kauffmann, F, Kowalski, Ml, LODRUP CARLSEN, K, Mullol, J, NIZANKOWSKA MOGILNICKA, E, Papadopoulos, N, Toskala, E, Wickman, M, Anto, J, Auvergne, N, Bachert, C, Bousquet, Pj, Brunekreef, B, Canonica, Gw, Carlsen, Kh, Gjomarkaj, M, Haahtela, T, Howarth, P, Lenzen, G, Lotvall, J, Radon, K, Ring, J, Salapatas, M, Schünemann, Hj, Szczecklik, A, TODO BOM, A, Valovirta, E, VON MUTIUS, E, Zock, Jp, Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS
Subjects: Male, Economic growth, Allergy, media_common.quotation_subject, International Cooperation, Immunology, Globality, 03 medical and health sciences, 0302 clinical medicine, Sex Factors, Excellence, medicine, Hypersensitivity, Immunology and Allergy, Network of excellence, media_common.cataloged_instance, Humans, European union, Cooperative Behavior, Program Development, 030304 developmental biology, media_common, Asthma, 0303 health sciences, Clinical Trials as Topic, business.industry, Environmental exposure, Environmental Exposure, Allergens, medicine.disease, 3. Good health, Europe, 030228 respiratory system, European Research Area, Female, business
Abstract: Udgivelsesdato: 2009-Jul Allergic diseases represent a major health problem in Europe. They are increasing in prevalence, severity and costs. The Global Allergy and Asthma European Network (GA(2)LEN), a Sixth EU Framework Program for Research and Technological Development (FP6) Network of Excellence, was created in 2005 as a vehicle to ensure excellence in research bringing together research and clinical institutions to combat fragmentation in the European research area and to tackle allergy in its globality. The Global Allergy and Asthma European Network has benefited greatly from the voluntary efforts of researchers who are strongly committed to this model of pan-European collaboration. The network was organized in order to increase networking for scientific projects in allergy and asthma around Europe and to make GA(2)LEN the world leader in the field. Besides these activities, research has also been carried out and the first papers are being published. Achievements of the Global Allergy and Asthma European Network can be grouped as follows: (i) those for a durable infrastructure built up during the project phase, (ii) those which are project-related and based on these novel infrastructures, and (iii) the development and implementation of guidelines. The major achievements of GA(2)LEN are reported in this paper.
Published: 2009
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35. GA2LEN SKIN TEST STUDY III: MINIMUM BATTERY OF TEST INHALENT ALLERGENS NEEDED IN EPIDEMIOLOGICAL STUDIES IN PATIENTS

Author: Bousquet, P J, Burbach, G, Heinzerling, L M, Edenharter, G, Bachert, C, Bindslev-Jensen, C, Bonini, S, Bousquet-Rouanet, L, Demoly, P, Bresciani, M, Bruno, A, Gjomarkaj, M, Canonica, G W, Darsow, U, Durham, S, Fokkens, W J, Giavi, S, Gramiccioni, C, Papadopoulos, N G, Haahtela, T, Kowalski, M L, Magyar, P, Muraközi, G, Orosz, M, Röhnelt, C, Stingl, G, Todo-Bom, A, von Mutius, E, Wiesner, A, Wöhrl, S, Bousquet, J, Zuberbier, T, Bousquet, Pj, Burbach, G, Heinzerling, Lm, Edenharter, G, Bachert, C, BINDSLEV JENSEN, C, Bonini, Sergio, BOUSQUET ROUANET, L, Demoly, P, Bresciani, M, Bruno, A, Gjomarkaj, M, Canonica, Gw, Darsow, U, Durham, S, Fokkens, Wj, Giavi, S, Gramiccioni, C, Papadopoulos, Ng, Haahtela, T, Kowalski, Ml, Magyar, P, Muraközi, G, Orosz, M, Röhnelt, C, Stingl, G, TODO BOM, A, VON MUTIUS, E, Wiesner, A, Wöhrl, S, Bousquet, J, Zuberbier, T., and University of Zurich
Subjects: Adult, Male, 2403 Immunology, 610 Medicine & health, Allergens, Middle Aged, Health Surveys, Europe, Young Adult, 10036 Medical Clinic, Hypersensitivity, Prevalence, 2723 Immunology and Allergy, Animals, Humans, Female, Skin Tests
Abstract: The number of allergens to be tested in order to identify sensitized patients is important in order to have the most cost-effective approach in epidemiological studies.To define the minimal number and the type of skin prick test (SPT) allergens required to identify a patient as sensitized using results of the new Pan-European GA(2)LEN skin prick test study.In a large Pan-European multicenter (17 centers in 14 countries) patient based study, a standardized panel of 18 allergens has been prick tested using a standardized procedure. Conditional approach allowed to determine the allergens selection.Among the 3034 patients involved, 1996 (68.2%) were sensitized to at least one allergen. Overall, eight allergens (grass pollen, Dermatophagoides pteronyssinus, birch pollen, cat dander, Artemisia, olive pollen, Blatella and Alternaria) allowed to identified more than 95% of sensitized subjects. However, differences were observed between countries, two allergens being sufficient for Switzerland (grass pollen and cat dander) as opposed to nine for France (grass pollen, Dermatophagoides pteronyssinus, olive pollen, cat dander, Blatella, cypress, dog dander, alder and [Artemisia or Alternaria]). According to country, up to 13 allergens were needed to identify all sensitized subjects.Eight to ten allergens allowed the identification of the majority of sensitized subjects. For clinical care of individual patients, the whole battery of 18 allergens is needed to appropriately assess sensitization across Europe.
Published: 2009

36. The impact of GINA suggested drugs for the treatment of asthma on Health-Related Quality of Life: a GA(2)LEN review

Author: Pascal Demoly, Philippe-Jean Bousquet, F. Braido, G.W. Canonica, T. Zuberbier, Ilaria Baiardini, Sergio Bonini, F. Tarantini, Silvia Brandi, Baiardini, I, Braido, F, Brandi, S, Tarantini, F, Bonini, Sergio, Bousquet, Pj, Zuberbier, T, Demoly, P, and Canonica, Gw
Subjects: Health related quality of life, medicine.medical_specialty, Allergy, business.industry, Immunology, medicine.disease, Asthma, respiratory tract diseases, Surgery, Treatment Outcome, Quality of life (healthcare), Pharmacotherapy, Surveys and Questionnaires, Quality of Life, Global health, Humans, Immunology and Allergy, Medicine, Anti-Asthmatic Agents, Airway Remodelling, business, Airway, Intensive care medicine
Abstract: Asthma represents a serious global health problem. People of all ages in countries throughout the world are affected by this chronic airway disorder that, when uncontrolled, can place severe limits on daily life and can even be fatal. Asthma cannot be removed, but asthmatic symptoms can be cured; as for many other chronic diseases, pharmacotherapy is important to reduce the risk of asthma-related mortality, decrease disability and improve symptoms and quality of life. The action of antiasthmatic drugs directly contributes to decrease symptoms severity, improve spirometric results, reduce airway hyperresponsiveness and prevent irreversible airway remodelling. Antiasthmatic therapy is necessary for long-term control of asthma symptoms. Asthma and antiasthmatic drugs can influence patient's quality of life: this is why healthcare systems have recently focused on research studies about Health-Related Quality of Life (HRQL) in asthmatic patients. Numerous validated questionnaires are available and many studies have been performed evaluating HRQL in people affected by asthma, thus testifying a great interest in this topic. The aims of the present review are to examine the scientific literature of the last 4 years (January 2004-December 2007) dealing with the impact of asthma treatments suggested by Global Initiative for Asthma guidelines on patients' quality of life, and to identify the unexplored or not fully investigated areas concerning this issue.
Published: 2008

37. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)

Author: Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias, A., Zuberbier, T., Baena-Cagnani, C. E., Canonica, G. W., van Weel, C., Agache, I., Aït-Khaled, N., Bachert, C., Blaiss, M. S., Bonini, S., Boulet, L.-P., Bousquet, P.-J., Camargos, P., Carlsen, K.-H., Chen, Y., Custovic, A., Dahl, R., Demoly, P., Douagui, H., Durham, S. R., van Wijk, R Gerth, Kalayci, O., Kaliner, M. A., Kim, Y.-Y., Kowalski, M. L., Kuna, P., Le, L. T. T., Lemiere, C., Li, J., Lockey, R. F., Mavale-Manuel, S., Meltzer, E. O., Mohammad, Y., Mullol, J., Naclerio, R., O'Hehir, R. E., Ohta, K., Ouedraogo, S., Palkonen, S., Papadopoulos, N., Passalacqua, G., Pawankar, R., Popov, T. A., Rabe, K. F., Rosado-Pinto, J., Scadding, G. K., Simons, F. E. R., Toskala, E., Valovirta, E., van Cauwenberge, P., Wang, D.-Y., Wickman, M., Yawn, B. P., Yorgancioglu, A., Yusuf, O. M., Zar, H., Annesi-Maesano, Isabella, Bateman, E. D., Ben Kheder, A., Boakye, D. A., Bouchard, J., Burney, P., Busse, W. W., Chan-Yeung, M., Chavannes, N. H., Chuchalin, A., Dolen, W. K., Emuzyte, R., Grouse, L., Humbert, M., Jackson, C., Johnston, S. L., Keith, P. K., Kemp, J. P., Klossek, J.-M., Larenas-Linnemann, D., Lipworth, B., Malo, J.-L., Marshall, G. D., Naspitz, C., Nekam, K., Niggemann, B., Nizankowska-Mogilnicka, E., Okamoto, Y., Orru, M. P., Potter, P., Price, D., Stoloff, S. W., Vandenplas, O., Viegi, G., Williams, D., Renseigné, Non, Dermatology, Internal Medicine, Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), inconnu, Inconnu, Forschungszentrum Jülich GmbH - Projektträger BEO, GmbH, Photochimie moléculaire et macromoléculaire (PMM), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Department of Dermatology, Medical School-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], P&A Kyriakou Children's Hospital, Forschungszentrum Karlsruhe, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'étude des textures et application aux matériaux (LETAM), Université Paul Verlaine - Metz (UPVM)-Centre National de la Recherche Scientifique (CNRS), Université de Poitiers, Merlin Circuit Technology LTD, Bousquet J, N Khaltaev, RG van Wijk, Kalayci O, je Agache, MA Kaliner, YY Kim, Kowalski ML, Denburg J, P Kuna, Le LT, C Lemiere, KH Carlsen, Li J, Lockey RF, Manuel-S Mavale, Khaled Aït N, EO Meltzer, Mohammad Y, Mullol J, R Naclerio, Fokkens WJ, RE O'Hehir, Chen Y, K Ohta, S Ouedraogo, S Palkonen, N Papadopoulos, C Bachert, G Passalacqua, Pawankar R, TA Popov, KF Rabe, Rosado Pinto-J, Cruz AA, Togias A, GK Scadding, FE Simons, E Toskala, E Valovirta, MS Blaiss, P Van Cauwenberge, Wang DY, M Wickman, BP Yawn, Custovic A, Yorgancioglu A, OM Yusuf, T Zuberbier, H Zar, Annesi-Maesano I, ED Bateman, S Bonini, Ben Kheder A, DA Boakye, Bouchard J, R Dahl, P Burney, WW Busse, M Chan-Yeung, Chavannes NH, Baena-Cagnani CE, Chuchalin A, WK Dolen, LP Boulet, R Emuzyte, L Grouse, Demoly P, M Humbert, C Jackson, SL Johnston, Keith PK, JP Kemp, JM Klo, GW Canonica, C Weel van, Bousquet PJ, P Camargos, H Douagui, SR Durham, and Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut de Chimie du CNRS (INC)
Subjects: Rhinitis, Allergic, Perennial, MESH: Asthma, Adolescent, Global Health, World Health Organization, MESH: World Health Organization, MESH: Risk Factors, Risk Factors, MESH: Child, Effective Primary Care and Public Health [EBP 3], Prevalence, Humans, Child, ComputingMilieux_MISCELLANEOUS, MESH: Prevalence, MESH: Adolescent, MESH: Humans, MESH: Rhinitis, Allergic, Perennial, Cardiovascular diseases [NCEBP 14], Rhinitis, Allergic, Seasonal, MESH: Rhinitis, Allergic, Seasonal, Effective primary care and public health [NCEBP 7], Asthma, World Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: World Health
Abstract: Allergic rhinitis is a symptomatic disorder of the nose induced after allergen exposure by an IgE-mediated inflammation of the membranes lining the nose. It is a global health problem that causes major illness and disability worldwide. Over 600 million patients from all countries, all ethnic groups and of all ages suffer from allergic rhinitis. It affects social life, sleep, school and work and its economic impact is substantial. Risk factors for allergic rhinitis are well identified. Indoor and outdoor allergens as well as occupational agents cause rhinitis and other allergic diseases. The role of indoor and outdoor pollution is probably very important, but has yet to be fully understood both for the occurrence of the disease and its manifestations. In 1999, during the Allergic Rhinitis and its Impact on Asthma (ARIA) WHO workshop, the expert panel proposed a new classification for allergic rhinitis which was subdivided into 'intermittent' or 'persistent' disease. This classification is now validated. The diagnosis of allergic rhinitis is often quite easy, but in some cases it may cause problems and many patients are still under-diagnosed, often because they do not perceive the symptoms of rhinitis as a disease impairing their social life, school and work. The management of allergic rhinitis is well established and the ARIA expert panel based its recommendations on evidence using an extensive review of the literature available up to December 1999. The statements of evidence for the development of these guidelines followed WHO rules and were based on those of Shekelle et al. A large number of papers have been published since 2000 and are extensively reviewed in the 2008 Update using the same evidence-based system. Recommendations for the management of allergic rhinitis are similar in both the ARIA workshop report and the 2008 Update. In the future, the GRADE approach will be used, but is not yet available. Another important aspect of the ARIA guidelines was to consider co-morbidities. Both allergic rhinitis and asthma are systemic inflammatory conditions and often co-exist in the same patients. In the 2008 Update, these links have been confirmed. The ARIA document is not intended to be a standard-of-care document for individual countries. It is provided as a basis for physicians, health care professionals and organizations involved in the treatment of allergic rhinitis and asthma in various countries to facilitate the development of relevant local standard-of-care documents for patients.
Published: 2008
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38. IMPORTANT RESEARCH QUESTIONS IN ALLERGY AND RELATED DISEASES: NONALLERGIC RHINITIS: A GA2LEN PAPER

Author: J, Bousquet, W, Fokkens, P, Burney, S R, Durham, C, Bachert, C A, Akdis, G W, Canonica, S-E, Dahlen, T, Zuberbier, T, Bieber, S, Bonini, P J, Bousquet, J L, Brozek, L-O, Cardell, R, Crameri, A, Custovic, P, Demoly, R G, van Wijk, M, Gjomarkaj, C, Holland, P, Howarth, M, Humbert, S L, Johnston, F, Kauffmann, M L, Kowalski, B, Lambrecht, S, Lehmann, B, Leynaert, K, Lodrup-Carlsen, J, Mullol, B, Niggemann, E, Nizankowska-Mogilnicka, N, Papadopoulos, G, Passalacqua, H J, Schünemann, H-U, Simon, A, Todo-Bom, E, Toskala, R, Valenta, M, Wickman, J P, Zock, Bousquet, J, Fokkens, W, Burney, P, Durham, Sr, Bachert, C, Akdis, Ca, Canonica, Gw, Dahlen, Se, Zuberbier, T, Bieber, T, Bonini, Sergio, Bousquet, Pj, Brozek, Jl, Cardell, Lo, Crameri, R, Custovic, A, Demoly, P, VAN WIJK, Rg, Gjomarkaj, M, Holland, C, Howarth, P, Humbert, M, Johnston, Sl, Kauffmann, F, Kowalski, Ml, Lambrecht, B, Lehmann, S, Leynaert, B, LODRUP CARLSEN, K, Mullol, J, Niggemann, B, NIZANKOWSKA MOGILNICKA, E, Papadopoulos, N, Passalacqua, G, Schünemann, Hj, Simon, Hu, TODO BOM, A, Toskala, E, Valenta, R, Wickman, M, Zock, Jp, Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Internal Medicine, Pulmonary Medicine, and University of Zurich
Subjects: Proteomics, 2403 Immunology, [SDV.GEN]Life Sciences [q-bio]/Genetics, Anti-Inflammatory Agents, Non-Steroidal, Disease Management, Autoimmunity, 610 Medicine & health, Comorbidity, Dendritic Cells, Genomics, Immunoglobulin E, T-Lymphocytes, Regulatory, Immunity, Innate, Cohort Studies, Europe, Phenotype, 10183 Swiss Institute of Allergy and Asthma Research, Surveys and Questionnaires, Prevalence, 2723 Immunology and Allergy, Humans, Sinusitis, ComputingMilieux_MISCELLANEOUS, Rhinitis
Abstract: Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis.
Published: 2008
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39. Association between the antibiotics use and recurrence in patients with resected colorectal cancer: EVADER-1, a nation-wide pharmaco-epidemiologic study.

Author: Hilmi M, Khati I, Turpin A, Andremont A, Burdet C, Grall N, Vidal J, Bousquet PJ, Rousseau B, and Bihan-Benjamin CL
Subjects: Humans, Female, Male, Aged, Middle Aged, France epidemiology, Disease-Free Survival, Proportional Hazards Models, Aged, 80 and over, Multivariate Analysis, Pharmacoepidemiology, Retrospective Studies, Adult, Risk Factors, Colorectal Neoplasms surgery, Colorectal Neoplasms pathology, Neoplasm Recurrence, Local epidemiology, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents administration & dosage
Abstract: Background: The impact of antibiotics (ATBs) on the risk of colorectal cancer (CRC) recurrence after curative resection remains unknown., Methods: Using the French nation-wide database of cancer patients, all newly diagnosed non-metastatic CRC patients resected between 01/2012 and 12/2014 were included. The perioperative ATB intake (from 6 months before surgery until 1 year after) was classified according to the class, the period of use (pre- vs post-resection), the disease stage (localized and locally advanced), and the primary tumor location (colon and rectum/junction). The primary endpoint was the 3-year disease-free survival (DFS). The impact of ATB was assessed using time-dependent multivariate Cox models., Results: A total of 35,496 CRC patients were included. Seventy-nine percent of patients had at least one ATB intake. Outpatient ATB intake after surgery was associated with unfavorable 3-year DFS. The ATBs associated with decreased 3-year DFS were cephalosporins, streptogramins, quinolones, penicillin A with beta-lactamase inhibitors, and antifungals with differential effects according to the primary tumor location and disease stage., Conclusion: These findings suggest that ATBs modulate the risk of recurrence after early CRC resection with a differential impact of the ATB classes depending on disease stage and tumor site., Competing Interests: Conflicts of interest A.T. reports personal fees from SERVIER, personal fees from MYLAN, personal fees from MERCK SERONO, personal fees from AMGEN, non-financial support from MERCK, non-financial support from SANOFI, non-financial support from PFIZER, outside the submitted work. C.B. reports personal fees and non-financial support from Da Volterra, personal fees from MYLAN, outside the submitted work. J.V. reports personal fees from BMS, personal fees from Merck-Serono, personal fees from Novartis, personal fees from Guardant Health, personal fees from Sanofi, outside the submitted work. A.A. reports personal fees and other from DaVolterra, outside the submitted work; In addition, A.A. has a patent DaVolterra issued. B.R. reports consulting/advisory role for Neophore, Bayer, Roche, Novartis, Gilead, Servier; Travel, accommodations, and expenses from Bayer, Servier, Astellas; salary support from Nuovo Soldati Foundation in 2019 and funding including salary support from Swim Across America foundation in 2020. The remaining authors disclose no conflicts., (Copyright © 2024 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
Published: 2025
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40. Cancer Risk Among Patients With Multiple Sclerosis: A 10-Year Nationwide Retrospective Cohort Study.

Author: Pierret C, Mulliez A, Le Bihan-Benjamin C, Moisset X, Bousquet PJ, and Leray E
Subjects: Humans, Male, Female, Middle Aged, Retrospective Studies, Adult, Incidence, France epidemiology, Aged, Cohort Studies, Risk Factors, Young Adult, Multiple Sclerosis epidemiology, Neoplasms epidemiology
Abstract: Background and Objectives: Previous literature has been diverging on cancer risk in people with multiple sclerosis (PwMS). Therefore, this study compared the risk of cancer in PwMS and a matched sample from the French general population., Methods: This 10-year nationwide retrospective matched cohort study (2012-2021) used data from the national French administrative health care database (99% coverage of the French population) to determine the time to the first incident cancer. PwMS were identified using their long-term disease (LTD) status, hospitalizations, and multiple sclerosis (MS)-specific drug reimbursements. The control population was matched 4:1 on age, sex, residence, insurance scheme, and cohort entry date. Participants were included if they had no history of cancer in the 3 years before inclusion. Patients with cancer were identified through LTD status, hospitalizations, chemotherapy, radiotherapy, or prostate cancer-specific drug reimbursements. Overall and cancer location-specific hazard ratios (HRs) for the first incident cancer were obtained from Fine and Gray models, and age- and sex-stratified estimates were reported. Participation in cancer screening through the 3 national programs (breast, colorectal, and cervical) were compared between groups., Results: Cancer incidence was 799 per 100,000 person-years (PYs) (n = 8,368) among the 140,649 PwMS and 736 per 100,000 PYs (n = 31,796) among the 562,596 matched controls (70.8% of women; follow-up: 7.6 ± 3.2 years). A small overall risk increase was observed for PwMS (HR 1.06, 95% CI 1.03-1.08), mostly in women (HR 1.08, 95% CI 1.05-1.11). Risk varied by cancer types and was lower for prostate (HR 0.80, 95% CI 0.73-0.88), breast (HR 0.91, 95% CI 0.86-0.95), and colorectal (HR 0.90, 95% CI 0.84-0.97) cancer and higher for bladder (HR 1.71, 95% CI 1.54-1.89), brain (HR 1.68, 95% CI 1.42-1.98), and cervical (HR 1.24, 95% CI 1.12-1.38) cancer in PwMS. Cancer risk was higher in PwMS younger than 55 years (HR 1.20, 95% CI 1.15-1.24) but decreased in PwMS aged 65 years and older (HR 0.89, 95% CI 0.85-0.94). This trend was found in all cancer locations. There were fewer PwMS getting screened than controls (all programs), with a particularly pronounced difference among those aged 65 years and older., Discussion: Cancer risk was slightly increased in PwMS, particularly for urogenital cancers, possibly due to surveillance bias. Risk fluctuated depending on age, perhaps due to varying generational screening practices (i.e., diagnosis neglect in the older PwMS) and risk factors.
Published: 2024
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41. Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses.

Author: Wang M, Rousseau B, Qiu K, Huang G, Zhang Y, Su H, Le Bihan-Benjamin C, Khati I, Artz O, Foote MB, Cheng YY, Lee KH, Miao MZ, Sun Y, Bousquet PJ, Hilmi M, Dumas E, Hamy AS, Reyal F, Lin L, Armistead PM, Song W, Vargason A, Arthur JC, Liu Y, Guo J, Zhou X, Nguyen J, He Y, Ting JP, Anselmo AC, and Huang L
Subjects: Animals, Mice, Humans, Antigens, Neoplasm immunology, Colorectal Neoplasms immunology, Colorectal Neoplasms drug therapy, Colorectal Neoplasms microbiology, Immunotherapy methods, Cell Line, Tumor, Liposomes, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use
Abstract: Increasing evidence implicates the tumor microbiota as a factor that can influence cancer progression. In patients with colorectal cancer (CRC), we found that pre-resection antibiotics targeting anaerobic bacteria substantially improved disease-free survival by 25.5%. For mouse studies, we designed an antibiotic silver-tinidazole complex encapsulated in liposomes (LipoAgTNZ) to eliminate tumor-associated bacteria in the primary tumor and liver metastases without causing gut microbiome dysbiosis. Mouse CRC models colonized by tumor-promoting bacteria (Fusobacterium nucleatum spp.) or probiotics (Escherichia coli Nissle spp.) responded to LipoAgTNZ therapy, which enabled more than 70% long-term survival in two F. nucleatum-infected CRC models. The antibiotic treatment generated microbial neoantigens that elicited anti-tumor CD8 + T cells. Heterologous and homologous bacterial epitopes contributed to the immunogenicity, priming T cells to recognize both infected and uninfected tumors. Our strategy targets tumor-associated bacteria to elicit anti-tumoral immunity, paving the way for microbiome-immunotherapy interventions., (© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Published: 2024
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42. Concomitant medication, comorbidity and survival in patients with breast cancer.

Author: Dumas E, Grandal Rejo B, Gougis P, Houzard S, Abécassis J, Jochum F, Marande B, Ballesta A, Del Nery E, Dubois T, Alsafadi S, Asselain B, Latouche A, Espie M, Laas E, Coussy F, Bouchez C, Pierga JY, Le Bihan-Benjamin C, Bousquet PJ, Hotton J, Azencott CA, Reyal F, and Hamy AS
Subjects: Humans, Female, Cohort Studies, Comorbidity, Simvastatin, Breast Neoplasms drug therapy, Breast Neoplasms epidemiology, Breast Neoplasms pathology
Abstract: Between 30% and 70% of patients with breast cancer have pre-existing chronic conditions, and more than half are on long-term non-cancer medication at the time of diagnosis. Preliminary epidemiological evidence suggests that some non-cancer medications may affect breast cancer risk, recurrence, and survival. In this nationwide cohort study, we assessed the association between medication use at breast cancer diagnosis and survival. We included 235,368 French women with newly diagnosed non-metastatic breast cancer. In analyzes of 288 medications, we identified eight medications positively associated with either overall survival or disease-free survival: rabeprazole, alverine, atenolol, simvastatin, rosuvastatin, estriol (vaginal or transmucosal), nomegestrol, and hypromellose; and eight medications negatively associated with overall survival or disease-free survival: ferrous fumarate, prednisolone, carbimazole, pristinamycin, oxazepam, alprazolam, hydroxyzine, and mianserin. Full results are available online from an interactive platform ( https://adrenaline.curie.fr ). This resource provides hypotheses for drugs that may naturally influence breast cancer evolution., (© 2024. The Author(s).)
Published: 2024
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43. Challenges of artificial intelligence in precision oncology: public-private partnerships including national health agencies as an asset to make it happen.

Author: Luu VP, Fiorini M, Combes S, Quemeneur E, Bonneville M, and Bousquet PJ
Subjects: Humans, Public-Private Sector Partnerships, Artificial Intelligence, Precision Medicine, Medical Oncology, Neoplasms diagnosis, Neoplasms therapy
Abstract: Competing Interests: Disclosure VPL is employed by Artificial Intelligence and Cancers Association. MF is employed by Artificial Intelligence and Cancers Association. SC is employed by the French Health Data Hub, which is an independent national health agency and a member of Artificial Intelligence and Cancers Association. EQ is employed by France Biotech, which is a member of Artificial Intelligence and Cancers Association. MB is employed by the Health Industry Alliance for Research and Innovation (ARIIS), which is a member of Artificial Intelligence and Cancers Association. PJB is employed by the French National Institute of Cancer, which is an independent national health agency and a member of Artificial Intelligence and Cancers Association.
Published: 2024
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44. [Cancers in France: 10 key messages].

Author: Ifrah N, Méric JB, and Bousquet PJ
Subjects: Humans, Medical Oncology, France, Neoplasms
Abstract: Competing Interests: Les auteurs déclarent n’avoir aucun lien d’intérêts.
Published: 2024

45. [Cancers: incidence and survival in metropolitan France].

Author: De Brauer C, Bousquet PJ, and Lafay L
Subjects: Humans, Male, Incidence, France epidemiology, Survival Rate, Registries, Neoplasms epidemiology, Neoplasms therapy, Prostatic Neoplasms, Melanoma, Breast Neoplasms
Abstract: Cancers: INCIDENCE AND SURVIVAL IN METROPOLITAN France. Incidence and survival rates are key indicators for cancer surveillance. They also help to drive cancer control programs and public health policies. Focusing on the main cancer localisations, this paper describes the latest incidence (2023) and survival (2018) rates, as well as their evolutions since 1990 in metropolitan France. In 2023, the number of new cases of cancer was estimated to be 433 136, of which 57% occurring in men. Both gender considered, the most frequent cancers are: breast cancer (61 214 new cases), prostate cancer (59 885 new cases) and lung cancer (52 777 new cases). Although the « all cancer » incidence rate as remained quite stable for 33 years in men, it has been raising by almost 1% per year in women. Regarding survival, the standardized net survival (SNS) at 5 years shows great disparities among tumor sites, and it is overall higher in women. Cancers with the best prognosis are thyroid cancer (SNS at 5 years: 96%), prostate cancer (93%), skin melanoma (93%) and uterine cancer (74%). On the contrary, a few tumor locations, including the pancreas (SNS at 5 years of 11%), the liver (18%) and the lung (20%) are still associated with a poor prognosis, even if survival rates have increased in most of cancer locations since 1990., Competing Interests: Les auteurs déclarent n’avoir aucun lien d’intérêts.
Published: 2024

46. [After cancer: after-eff ects, return to work and the right to forget].

Author: Foucaud J and Bousquet PJ
Subjects: Humans, Employment, Neoplasms epidemiology, Neoplasms therapy, Return to Work
Abstract: After Cancer: AFTER-EFFECTS. RETURN TO WORK AND THE RIGHT TO FORGET. The ten-year strategy 2021-2030 against cancers makes staying at work or returning to work after cancer a major priority. A growing number of patients are on the job market at the time of their cancer diagnosis, with a potentially long career future. The after-effects of the disease, and the gap between them and the professional world, present them with numerous difficulties. French national cancer institute (INCa) has launched several initiatives to help people stay in work and return to work, in particular to complement the measures developed by the League against Cancer. INCa has set up the «Cancer and Employment» Business Club, a forum for the exchange of best practices and experiences between employers and researchers in the human and social sciences. The «Cancer aide info réseau entrepreneur» (CAIRE) scheme supports self-employed patients in their professional careers, and gives them a voice in their professional ecosystem. Research initiatives are also undertaken. The social repercussions of the disease also include its impact on borrowing capacity, for both personal and business loans. The "right to be forgotten" for cancer sufferers applies 5 years after the end of the therapeutic protocol. A grid completes the system, and in certain cases enables insurances for a loan can be obtained on standard or similar terms, even before this period has elapsed. It also includes other pathologies such as HIV, hepatitis C and cystic fibrosis. Last but not least, health questionnaires have been abolished for loans under €200,000. The role of the health professional is paramount, providing advice and facilitating the completion of documents requested by insurers., Competing Interests: Les auteurs déclarent n’avoir aucun lien d’intérêts.
Published: 2024

47. Hypoparathyroidism-related health care utilization and expenditure during the first postoperative year after total thyroidectomy for cancer: a comprehensive national cohort study.

Author: Benmiloud F, Le Bihan C, Rebaudet S, Marino P, Bousquet PJ, and Bouée-Benhamiche E
Subjects: Adult, Humans, Female, Middle Aged, Male, Thyroidectomy adverse effects, Cohort Studies, Calcium, Health Expenditures, Vitamin D therapeutic use, Calcium, Dietary, Patient Acceptance of Health Care, Hypocalcemia complications, Hypoparathyroidism epidemiology, Hypoparathyroidism etiology, Thyroid Neoplasms complications
Abstract: Objectives: Hypoparathyroidism is the most common complication of total thyroidectomy for cancer, and requires calcium and/or vitamin D supplementation for an unpredictable period of time. The additional cost associated with this complication has not hitherto been assessed. The aim of this study was to assess the economic burden of postoperative hypoparathyroidism after total thyroidectomy for cancer in France., Methods: Based on the French national cancer cohort, which extracts data from the French National Health Data System (SNDS), all adult patients who underwent a total thyroidectomy for cancer in France between 2011 and 2015 were identified, and their healthcare resource use during the first postoperative year was compared according to whether they were treated postoperatively with calcium and/or vitamin D or not. Univariate and multivariate cost analyses were performed with the non-parametric Wilcoxon test and generalized linear model (gamma distribution and log link), respectively., Results: Among the 31,175 patients analyzed (75% female, median age: 52y), 13,247 (42%) started calcium and/or vitamin D supplementation within the first postoperative month, and 2,855 patients (9.1%) were still treated at 1 year. Over the first postoperative year, mean overall and specific health expenditures were significantly higher for treated patients than for untreated patients: €7,233 vs €6,934 per patient (p<0.0001) and €478.6 vs €332.7 per patient (p<0.0001), respectively. After adjusting for age, gender, Charlson Comorbidity index, ecological deprivation index, types of thyroid resection, lymph node dissection and complications, year and region, the incremental cost of overall health care utilization was €142 (p<0.004)., Conclusion: Our study found a significant additional cost in respect of health expenditures for patients who had hypoparathyroidism after thyroidectomy for cancer, over the first postoperative year. Five-year follow-up is planned to assess the impact of more severe long-term complications on costs., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Benmiloud, Le Bihan, Rebaudet, Marino, Bousquet and Bouée-Benhamiche.)
Published: 2023
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48. Estimation of Oncologic Surgery Case Volume Before and After the COVID-19 Pandemic in France.

Author: Le Bihan-Benjamin C, Rocchi M, Putton M, Méric JB, and Bousquet PJ
Subjects: Adult, Female, Humans, Pandemics, Cross-Sectional Studies, France epidemiology, COVID-19 epidemiology, Breast Neoplasms, Urologic Neoplasms
Abstract: Importance: COVID-19 has had a major effect on health care activities, especially surgery. At first, comparisons were proposed using 2019 activities as the highest standard. However, while such an approach might have been suitable during the first months of the pandemic, this might no longer be the case for a longer period., Objective: To examine approaches that may better assess the use of cancer surgeries., Design, Setting, and Participants: In a cross-sectional design, the nationwide French hospital facility data (Medicalised Information System Program) were used to assess cancer surgery for 6 cancer site categories in adults from January 1, 2010, to December 31, 2021., Exposure: Estimated cancer surgery activity during the COVID-19 pandemic., Main Outcomes and Measures: Three models were proposed to assess the expected number of surgical procedures between 2020 and 2021 and make a comparison with those observed in earlier years., Results: In France, cancer removal surgeries account for approximately 7000 hospitalizations per year for liver cancer; 4000 for pancreatic cancer; 7700 for ovarian cancer; 1300 for esophagus cancer; 23 000 for ear, nose, and throat (ENT) cancer; 78 000 for breast cancer; and 16 600 for thoracic cancers. For most cancer sites, the number of surgical procedures increased from 2010 to 2019: liver, 14%; pancreas, 38%; ovary, 14%; esophagus, 18%; breast, 8%; and thoracic, 29%. Assuming stability, these values underestimate the gap in activity observed in 2020-2021. For other procedures, a decrease was observed: stomach, -10%, and ENT, -6%. Assuming stability, these values overestimate the gap in activity observed in 2020-2021. At the end of 2021, according to the model, the gap in activity observed in 2020-2021 was estimated at between -1.4% and 1.7% for breast, -6.6% and -7.3% for thoracic, -3.1% and -2.5% for ovarian, -4.2% and -1.7% for pancreas, -6.7% and 5.9% for stomach, and -13.0% and -13.9% for esophageal cancers. For ENT, liver, and urologic cancers, because the trend was different before and after 2015, it was necessary to opt for modeling using only the most recent period. The cumulative gap in activity observed in 2020-2021 was estimated at -1.0% for ENT cancers, -5.3% for liver cancers, and -2.9% for urologic cancers., Conclusions and Relevance: The findings of this study suggest that short- and medium-term trends must be considered to estimate COVID-19 cancer surgery activities. Breast cancer is the site for which the activity showed the smallest decrease during the pandemic, with almost full recovery in 2021.
Published: 2023
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49. Monitoring Breast Cancer Care Quality at National and Local Level Using the French National Cancer Cohort.

Author: Houzard S, Courtois E, Le Bihan Benjamin C, Erbault M, Arnould L, Barranger E, Coussy F, Couturaud B, Cutuli B, de Cremoux P, de Reilhac P, de Seze C, Foucaut AM, Gompel A, Honoré S, Lesur A, Mathelin C, Verzaux L, and Bousquet PJ
Subjects: Female, Humans, Mastectomy, Segmental, Quality Indicators, Health Care, Quality of Health Care, Radiotherapy, Adjuvant, Breast Neoplasms pathology
Abstract: Purpose: The French National Cancer Institute has developed, in partnership with the French National Authority for Health, breast cancer-specific Care Quality, and Safety Indicators (BC QIs). With regard to the most common form of cancer, our aim is to support local and national quality initiatives, to improve BC pathways and outcomes, reduce heterogeneity of practice and regional inequities. In this study, we measure the BC QIs available in the French National medico-administrative cancer database, the French Cancer Cohort, for 2018., Materials and Methods: BC QIs are developed according to the RAND method. QIs are based on good clinical practice and care pathway recommendations. QI computation should be automatable without any additional workload for data collection. They will be published annually for all stakeholders, and especially hospitals., Results: Finally, ten feasible and pertinent QIs were selected. In France, BC care was found to be close to compliance with most QIs: proportion of patients undergoing biopsy prior to first treatment (94.5%), proportion of patients undergoing adjuvant radiotherapy after breast-conserving surgery for BC (94.5%), proportion of women undergoing radiotherapy within 12 weeks after surgery and without chemotherapy (86.2%), proportion of DCIS patients undergoing immediate breast reconstruction (54.3%) and proportion of women with NMIBC undergoing breast reintervention (14.4%). However, some are still far from their recommended rate. In particular, some QIs vary considerably from one region, or one patient, to another., Conclusion: Each result needs to be analyzed locally to find care quality leverage. This will strengthen transparency actions aimed at the public., Competing Interests: Disclosure The authors declare that they have no conflict of interest., (Copyright © 2022. Published by Elsevier Inc.)
Published: 2022
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50. Care pathway of women with interval breast cancer in 2016, based on medico-administrative data.

Author: Bertrand C, Bihan-Benjamin CL, Molinié F, Rogel A, Méric JB, Ifrah N, and Bousquet PJ
Subjects: Critical Pathways, Female, Humans, Mammography, Mass Screening methods, Prognosis, Breast Neoplasms drug therapy, Breast Neoplasms therapy
Abstract: Background: Since 2004, an organised screening programme (OS) for breast cancer has been in place for 50-74 years women who are not at an increased risk. Despite this, 17% of cancers diagnosed within 24 months following an OS mammogram are interval cancers (IC), diagnosed even though the OS had not reported cancer. After identifying IC from the French administrative healthcare database (SNDS), our objective was to describe the care pathways of women with IC in 2016., Materials and Methods: The IC identification algorithm is based on breast imaging tests conducted in the 24 months prior to diagnosis and on the compatibility of their timeline with ACR3 lesion follow-up (BIRADS guidelines). The care pathways of 3 groups were compared: women with IC, diagnosed through the OS, and diagnosed outside the OS programme (personalised screening or based on clinical signs, PSCS group)., Results: Respectively, 12,965 (46%), 3433 (12%), and 11,761 women (42%) were classified in the OS, IC and PSCS groups, i.e. 20.9% IC cases among the women taking part in the OS programme. The women from the IC group presented with more forms with lymph node or metastatic involvement than those of the OS group. Their pathways were more complex than in the OS group: at an equivalent stage, more total mastectomies and more adjuvant or neoadjuvant chemotherapy regimens., Conclusion: The care pathways of women with IC are intermediate with respect to those of the OS or PSCS group.Cases of IC probably include several cancer prognosis profiles., (Copyright © 2021. Published by Elsevier Inc.)
Published: 2022
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