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236 results on '"Bouska, Alyssa"'

1. Genomic profiling identifies distinct genetic subtypes in extra-nodal natural killer/T-cell lymphoma

Author

Dong, Gehong, Liu, Xuxiang, Wang, Lifu, Yin, Wenjuan, Bouska, Alyssa, Gong, Qiang, Shetty, Kunal, Chen, Lu, Sharma, Sunandini, Zhang, Jibin, Lome-Maldonado, Carmen, Quintanilla-Martinez, Leticia, Li, Yuping, Song, Joo Y., Zhang, Wenyan, Shi, Yunfei, Wang, Jinhui, Kong, Lingbo, Wu, Xiwei, Wang, Jingwen, Liu, Hong-gang, Kong, Lingfei, Sun, Wenyong, Liu, Weiping, Wang, Lili, McKeithan, Timothy W., Iqbal, Javeed, and Chan, Wing C.

Published
2022
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2. DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T cells in PTCL-NOS

Author

Herek, Tyler A., Bouska, Alyssa, Lone, Waseem, Sharma, Sunandini, Amador, Catalina, Heavican, Tayla B., Li, Yuping, Wei, Qi, Jochum, Dylan, Greiner, Timothy C., Smith, Lynette, Pileri, Stefano, Feldman, Andrew L., Rosenwald, Andreas, Ott, German, Lim, Soon Thye, Ong, Choon Kiat, Song, Joo, Jaffe, Elaine S., Wang, Gang Greg, Staudt, Louis, Rimsza, Lisa M., Vose, Julie, d'Amore, Francesco, Weisenburger, Dennis D., Chan, Wing C., and Iqbal, Javeed

Published
2022
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3. MYC overexpression in natural killer cell lymphoma: prognostic and therapeutic implications

Author

Bi, Chengfeng, primary, Huang, Yuhua, additional, Ali, Roshia, additional, Wang, Fang, additional, Yang, Xia, additional, Bouska, Alyssa, additional, Xu, Lu, additional, Hao, Xinbao, additional, Lunning, Matthew A., additional, Chan, Wing C., additional, Iqbal, Javeed, additional, Weisenburger, Dennis D., additional, Vose, Julie M., additional, and Fu, Kai, additional

Published
2024
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4. VAV1 mutations contribute to development of T-cell neoplasms in mice

Author

Fukumoto, Kota, Sakata-Yanagimoto, Mamiko, Fujisawa, Manabu, Sakamoto, Tatsuhiro, Miyoshi, Hiroaki, Suehara, Yasuhito, Nguyen, Tran B., Suma, Sakurako, Yanagimoto, Shintaro, Shiraishi, Yuichi, Chiba, Kenichi, Bouska, Alyssa, Kataoka, Keisuke, Ogawa, Seishi, Iqbal, Javeed, Ohshima, Koichi, and Chiba, Shigeru

Published
2020
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5. Reproducing the molecular subclassification of peripheral T-cell lymphoma–NOS by immunohistochemistry

Author

Amador, Catalina, Greiner, Timothy C., Heavican, Tayla B., Smith, Lynette M., Galvis, Karen Tatiana, Lone, Waseem, Bouska, Alyssa, D'Amore, Francesco, Pedersen, Martin Bjerregaard, Pileri, Stefano, Agostinelli, Claudio, Feldman, Andrew L., Rosenwald, Andreas, Ott, German, Mottok, Anja, Savage, Kerry J., de Leval, Laurence, Gaulard, Philippe, Lim, Soon Thye, Ong, Choon Kiat, Ondrejka, Sarah L., Song, Joo, Campo, Elias, Jaffe, Elaine S., Staudt, Louis M., Rimsza, Lisa M., Vose, Julie, Weisenburger, Dennis D., Chan, Wing C., and Iqbal, Javeed

Published
2019
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8. Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: genomic features and potential therapeutic targets

Author

Bouska, Alyssa, Bi, Chengfeng, Lone, Waseem, Zhang, Weiwei, Kedwaii, Ambreen, Heavican, Tayla, Lachel, Cynthia M., Yu, Jiayu, Ferro, Roberto, Eldorghamy, Nanees, Greiner, Timothy C., Vose, Julie, Weisenburger, Dennis D., Gascoyne, Randy D., Rosenwald, Andreas, Ott, German, Campo, Elias, Rimsza, Lisa M., Jaffe, Elaine S., Braziel, Rita M., Siebert, Reiner, Miles, Rodney R., Dave, Sandeep, Reddy, Anupama, Delabie, Jan, Staudt, Louis M., Song, Joo Y., McKeithan, Timothy W., Fu, Kai, Green, Michael, Chan, Wing C., and Iqbal, Javeed

Published
2017
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9. Chronic T cell receptor stimulation unmasks NK receptor signaling in peripheral T cell lymphomas via epigenetic reprogramming

Author

Carras, Sylvain, Chartoire, Dimitri, Mareschal, Sylvain, Heiblig, Mael, Marcais, Antoine, Robinot, Remy, Urb, Mirjam, Pommier, Roxane M., Julia, Edith, Chebel, Amel, Verney, Aurelie, Bertheau, Charlotte, Bardel, Emilie, Fezelot, Caroline, Courtois, Lucien, Lours, Camille, Bouska, Alyssa, Sharma, Sunandini, Lefebvre, Christine, Rouault, Jean-Pierre, Sibon, David, Ferrari, Anthony, Iqbal, Javeed, de Leval, Laurence, Gaulard, Philippe, Traverse-Glehen, Alexandra, Sujobert, Pierre, Blery, Mathieu, Salles, Gilles, Walzer, Thierry, Bachy, Emmanuel, and Genestier, Laurent

Subjects
Oncology, Experimental, T cells -- Receptors, Antigen receptors, T cell -- Health aspects -- Genetic aspects, Non-Hodgkin's lymphomas -- Genetic aspects -- Development and progression, Killer cells -- Health aspects -- Genetic aspects, Cellular signal transduction -- Genetic aspects -- Health aspects, Epigenetic inheritance -- Research, Cancer -- Research, Health care industry
Abstract

Peripheral T cell lymphomas (PTCLs) represent a significant unmet medical need with dismal clinical outcomes. The T cell receptor (TCR) is emerging as a key driver of T lymphocyte transformation. However, the role of chronic TCR activation in lymphomagenesis and in lymphoma cell survival is still poorly understood. Using a mouse model, we report that chronic TCR stimulation drove T cell lymphomagenesis, whereas TCR signaling did not contribute to PTCL survival. The combination of kinome, transcriptome, and epigenome analyses of mouse PTCLs revealed a NK cell-like reprogramming of PTCL cells with expression of NK receptors (NKRs) and downstream signaling molecules such as Tyrobp and SYK. Activating NKRs were functional in PTCLs and dependent on SYK activity. In vivo blockade of NKR signaling prolonged mouse survival, demonstrating the addiction of PTCLs to NKRs and downstream SYK/mTOR activity for their survival. We studied a large collection of human primary samples and identified several PTCLs recapitulating the phenotype described in this model by their expression of SYK and the NKR, suggesting a similar mechanism of lymphomagenesis and establishing a rationale for clinical studies targeting such molecules., Introduction Peripheral T cell lymphomas (PTCLs) are highly heterogenous, comprising at least 30 post-thymic (i.e., mature) T or NK cell-derived entities according to the current 2016 WHO classification (1). PTCLs [...]

Published
2021
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11. Figure.S7 from Genome-Wide miRNA Expression Profiling of Molecular Subgroups of Peripheral T-cell Lymphoma

Author

Lone, Waseem, primary, Bouska, Alyssa, primary, Sharma, Sunandini, primary, Amador, Catalina, primary, Saumyaranjan, Mallick, primary, Herek, Tyler A., primary, Heavican, Tayla B., primary, Yu, Jiayu, primary, Lim, Soon Thye, primary, Ong, Choon Kiat, primary, Slack, Graham W., primary, Savage, Kerry J., primary, Rosenwald, Andreas, primary, Ott, German, primary, Cook, James R., primary, Feldman, Andrew L., primary, Rimsza, Lisa M., primary, McKeithan, Timothy W., primary, Greiner, Timothy C., primary, Weisenburger, Dennis D., primary, Melle, Federica, primary, Motta, Giovanna, primary, Pileri, Stefano, primary, Vose, Julie M., primary, Chan, Wing C., primary, and Iqbal, Javeed, primary

Published
2023
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12. Table.S2-S5 from Genome-Wide miRNA Expression Profiling of Molecular Subgroups of Peripheral T-cell Lymphoma

Author

Lone, Waseem, primary, Bouska, Alyssa, primary, Sharma, Sunandini, primary, Amador, Catalina, primary, Saumyaranjan, Mallick, primary, Herek, Tyler A., primary, Heavican, Tayla B., primary, Yu, Jiayu, primary, Lim, Soon Thye, primary, Ong, Choon Kiat, primary, Slack, Graham W., primary, Savage, Kerry J., primary, Rosenwald, Andreas, primary, Ott, German, primary, Cook, James R., primary, Feldman, Andrew L., primary, Rimsza, Lisa M., primary, McKeithan, Timothy W., primary, Greiner, Timothy C., primary, Weisenburger, Dennis D., primary, Melle, Federica, primary, Motta, Giovanna, primary, Pileri, Stefano, primary, Vose, Julie M., primary, Chan, Wing C., primary, and Iqbal, Javeed, primary

Published
2023
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13. Table.S1 from Genome-Wide miRNA Expression Profiling of Molecular Subgroups of Peripheral T-cell Lymphoma

Author

Lone, Waseem, primary, Bouska, Alyssa, primary, Sharma, Sunandini, primary, Amador, Catalina, primary, Saumyaranjan, Mallick, primary, Herek, Tyler A., primary, Heavican, Tayla B., primary, Yu, Jiayu, primary, Lim, Soon Thye, primary, Ong, Choon Kiat, primary, Slack, Graham W., primary, Savage, Kerry J., primary, Rosenwald, Andreas, primary, Ott, German, primary, Cook, James R., primary, Feldman, Andrew L., primary, Rimsza, Lisa M., primary, McKeithan, Timothy W., primary, Greiner, Timothy C., primary, Weisenburger, Dennis D., primary, Melle, Federica, primary, Motta, Giovanna, primary, Pileri, Stefano, primary, Vose, Julie M., primary, Chan, Wing C., primary, and Iqbal, Javeed, primary

Published
2023
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19. IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma

Author

Wang, Chao, McKeithan, Timothy W., Gong, Qiang, Zhang, Weiwei, Bouska, Alyssa, Rosenwald, Andreas, Gascoyne, Randy D., Wu, Xiwei, Wang, Jinhui, Muhammad, Zahid, Jiang, Bei, Rohr, Joseph, Cannon, Andrew, Steidl, Christian, Fu, Kai, Li, Yuping, Hung, Stacy, Weisenburger, Dennis D., Greiner, Timothy C., Smith, Lynette, Ott, German, Rogan, Eleanor G., Staudt, Louis M., Vose, Julie, Iqbal, Javeed, and Chan, Wing C.

Published
2015
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20. Gene Expression Signatures for the Accurate Diagnosis of Peripheral T-Cell Lymphoma Entities in the Routine Clinical Practice

Author

Amador, Catalina, primary, Bouska, Alyssa, additional, Wright, George, additional, Weisenburger, Dennis D., additional, Feldman, Andrew L., additional, Greiner, Timothy C., additional, Lone, Waseem, additional, Heavican, Tayla, additional, Smith, Lynette, additional, Pileri, Stefano, additional, Tabanelli, Valentina, additional, Ott, German, additional, Rosenwald, Andreas, additional, Savage, Kerry J., additional, Slack, Graham, additional, Kim, Won Seog, additional, Hyeh, Young, additional, Li, Yuping, additional, Dong, Gehong, additional, Song, Joo, additional, Ondrejka, Sarah, additional, Cook, James R., additional, Barrionuevo, Carlos, additional, Lim, Soon Thye, additional, Ong, Choon Kiat, additional, Chapman, Jennifer, additional, Inghirami, Giorgio, additional, Raess, Philipp W., additional, Bhagavathi, Sharathkumar, additional, Gould, Clare, additional, Blombery, Piers, additional, Jaffe, Elaine, additional, Morris, Stephan W., additional, Rimsza, Lisa M., additional, Vose, Julie M., additional, Staudt, Louis, additional, Chan, Wing C., additional, and Iqbal, Javeed, additional

Published
2022
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23. Integrative Analysis of Genetic and Tumor Microenvironment Topology to Delineate Prognostic Subtypes in Mantle Cell Lymphoma

Author

Sharma, Sunandini, primary, Bouska, Alyssa C., additional, Gamboa, Alicia, additional, Ali, Roshia, additional, Issa, Issa Ismail, additional, Lone, Waseem G., additional, Jochum, Dylan T., additional, Zhang, Weiwei, additional, Elhag, Salma, additional, Ghersi, Dario, additional, ElGamal, Dalia, additional, Vose, Julie M., additional, Bi, Chengfeng, additional, Merchant, Akil, additional, and Iqbal, Javeed, additional

Published
2022
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25. SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters

Author

Groß, Elisabeth, Hilger, Ralf A., Schümann, Franziska Lea, Bauer, Marcus, Bouska, Alyssa, Rohde, Christian, Willscher, Edith, Lützkendorf, Jana, Müller, Lutz Peter, Edemir, Bayram, Mueller, Thomas, Herling, Marco, Binder, Mascha, Wickenhauser, Claudia, Iqbal, Javeed, Posern, Guido, and Weber, Thomas

Subjects
Medizin
Abstract

T-cell lymphomas are heterogeneous and rare lymphatic malignancies with unfavorable prognosis. Consequently, new therapeutic strategies are needed. The enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 and responsible for lysine 27 trimethylation of histone 3. EZH2 is overexpressed in several tumor entities including T-cell neoplasms leading to epigenetic and consecutive oncogenic dysregulation. Thus, pharmacological EZH2 inhibition is a promising target and its clinical evaluation in T-cell lymphomas shows favorable results. We have investigated EZH2 expression in two cohorts of T-cell lymphomas by mRNA-profiling and immunohistochemistry, both revealing overexpression to have a negative impact on patients’ prognosis. Furthermore, we have evaluated EZH2 inhibition in a panel of leukemia and lymphoma cell lines with a focus on T-cell lymphomas characterized for canonical EZH2 signaling components. The cell lines were treated with the inhibitors GSK126 or EPZ6438 that inhibit EZH2 specifically by competitive binding at the S-adenosylmethionine (SAM) binding site in combination with the common second-line chemotherapeutic oxaliplatin. The change in cytotoxic effects under pharmacological EZH2 inhibition was evaluated revealing a drastic increase in oxaliplatin resistance after 72 h and longer periods of combinational incubation. This outcome was independent of cell type but associated to reduced intracellular platinum. Pharmacological EZH2 inhibition revealed increased expression in SRE binding proteins, SREBP1/2 and ATP binding cassette subfamily G transporters ABCG1/2. The latter are associated with chemotherapy resistance due to increased platinum efflux. Knockdown experiments revealed that this was independent of the EZH2 functional state. The EZH2 inhibition effect on oxaliplatin resistance and efflux was reduced by additional inhibition of the regulated target proteins. In conclusion, pharmacological EZH2 inhibition is not suitable in combination with the common chemotherapeutic oxaliplatin in T-cell lymphomas revealing an EZH2-independent off-target effect. CA extern

Published
2023

27. Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma

Author

Bouska, Alyssa, McKeithan, Timothy W., Deffenbacher, Karen E., Lachel, Cynthia, Wright, George W., Iqbal, Javeed, Smith, Lynette M., Zhang, Weiwei, Kucuk, Can, Rinaldi, Andrea, Bertoni, Francesco, Fitzgibbon, Jude, Fu, Kai, Weisenburger, Dennis D., Greiner, Timothy C., Dave, Bhavana J., Gascoyne, Randy D., Rosenwald, Andreas, Ott, German, Campo, Elias, Rimsza, Lisa M., Delabie, Jan, Jaffe, Elaine S., Braziel, Rita M., Connors, Joseph M., Staudt, Louis M., and Chan, Wing-Chung

Published
2014
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28. Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance

Author

Islam, Ridwan, primary, Mishra, Juhi, additional, Polavaram, Navatha Shree, additional, Bhattacharya, Sreyashi, additional, Hong, Zhengdong, additional, Bodas, Sanika, additional, Sharma, Sunandini, additional, Bouska, Alyssa, additional, Gilbreath, Tyler, additional, Said, Ahmed M., additional, Smith, Lynette M., additional, Teply, Benjamin A., additional, Muders, Michael H., additional, Batra, Surinder K., additional, Datta, Kaustubh, additional, and Dutta, Samikshan, additional

Published
2022
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31. Genome-Wide miRNA Expression Profiling of Molecular Subgroups of Peripheral T-cell Lymphoma

Author

Lone, Waseem, primary, Bouska, Alyssa, additional, Sharma, Sunandini, additional, Amador, Catalina, additional, Saumyaranjan, Mallick, additional, Herek, Tyler A., additional, Heavican, Tayla B., additional, Yu, Jiayu, additional, Lim, Soon Thye, additional, Ong, Choon Kiat, additional, Slack, Graham W., additional, Savage, Kerry J., additional, Rosenwald, Andreas, additional, Ott, German, additional, Cook, James R., additional, Feldman, Andrew L., additional, Rimsza, Lisa M., additional, McKeithan, Timothy W., additional, Greiner, Timothy C., additional, Weisenburger, Dennis D., additional, Melle, Federica, additional, Motta, Giovanna, additional, Pileri, Stefano, additional, Vose, Julie M., additional, Chan, Wing C., additional, and Iqbal, Javeed, additional

Published
2021
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32. Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T-Cell Lymphoma

Author

Bouska, Alyssa, Zhang, Weiwei, Sharma, Sunandini, Holte, Harald, Shah, Ab Rauf, Lone, Waseem Gul, Cappelli, Luca Vincenzo, Fiore, Danilo, Gong, Qiang, Heavican-Foral, Tayla, Cannatella, Jeffrey, Amador, Catalina, Arif, Aiza, Smith, Lynette, Lim, Soon Thye, Ong, Choon Kiat, Feldman, Andrew L., Du, Ming-Qing, de Leval, Laurence, Greiner, Timothy C., Fu, Kai, Trøen, Gunhild, Vodak, Daniel, Nakken, Sigve, Delabie, Jan, Weinstock, David M., Pileri, Stefano A., Laginestra, Antonella, Kim, Kyeongjin, Pajvani, Utpal, Vose, Julie M., Weisenburger, Dennis D, Dave, Sandeep, Inghirami, Giorgio, Chan, Wing C., and Iqbal, Javeed

Published
2023
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33. EBV‐positive HIV‐associated diffuse large B cell lymphomas are characterized by JAK/STAT (STAT3) pathway mutations and unique clinicopathologic features

Author

Chapman, Jennifer R., primary, Bouska, Alyssa C., additional, Zhang, Weiwei, additional, Alderuccio, Juan Pablo, additional, Lossos, Izidore S., additional, Rimsza, Lisa M., additional, Maguire, Alanna, additional, Yi, Shuhua, additional, Chan, Wing C., additional, Vega, Francisco, additional, and Song, Joo Y., additional

Published
2021
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34. A novel MYC –non ‐ IG fusion in refractory diffuse large B‐cell lymphoma

Author

Wang, Cheng, primary, Althof, Pamela A., additional, Bi, Chengfeng, additional, Zhang, Weiwei, additional, Bouska, Alyssa C., additional, Tian, Tian, additional, Zhang, Xuan, additional, Jiang, Nanxi, additional, Yu, Guohua, additional, Cheng, Hongxia, additional, Iqbal, Javeed, additional, Vose, Julie M., additional, Sanmann, Jennifer N., additional, and Fu, Kai, additional

Published
2021
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35. Murine double minute 2: p53-independent roads lead to genome instability or death

Author

Bouska, Alyssa and Eischen, Christine M.

Subjects
DNA replication, Genomics, Tumor proteins, Biological sciences, Chemistry
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.tibs.2009.02.006 Byline: Alyssa Bouska (1), Christine M. Eischen (2) Abstract: The oncoprotein murine double minute 2 (Mdm2) is frequently overexpressed in many types of human malignancies. Although Mdm2 has an essential role in negatively regulating the p53 tumor suppressor, it also has less well characterized p53-independent functions that influence pathways that are crucial for controlling tumorigenesis. In addition to the impact Mdm2 has on p53-independent apoptosis, mounting evidence is linking increased Mdm2 levels to altered cell-cycle regulation, DNA replication and DNA repair leading to loss of genome stability. Mdm2 involvement in pathways that influence chromosome stability and cell death, distinct from its role in the p53 pathway, strengthens the position of Mdm2 as a desirable therapeutic target for the treatment of human cancers. Author Affiliation: (1) Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA (2) Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA

Published
2009

36. Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma

Author

Ma, Man Chun John, primary, Tadros, Saber, additional, Bouska, Alyssa, additional, Heavican, Tayla, additional, Yang, Haopeng, additional, Deng, Qing, additional, Moore, Dalia, additional, Akhter, Ariz, additional, Hartert, Keenan, additional, Jain, Neeraj, additional, Showell, Jordan, additional, Ghosh, Sreejoyee, additional, Street, Lesley, additional, Davidson, Marta, additional, Carey, Christopher, additional, Tobin, Joshua, additional, Perumal, Deepak, additional, Vose, Julie M., additional, Lunning, Matthew A., additional, Sohani, Aliyah R., additional, Chen, Benjamin J., additional, Buckley, Shannon, additional, Nastoupil, Loretta J., additional, Davis, R. Eric, additional, Westin, Jason R., additional, Fowler, Nathan H., additional, Parekh, Samir, additional, Gandhi, Maher, additional, Neelapu, Sattva, additional, Stewart, Douglas, additional, Bhalla, Kapil, additional, Iqbal, Javeed, additional, Greiner, Timothy, additional, Rodig, Scott J., additional, Mansoor, Adnan, additional, and Green, Michael R., additional

Published
2021
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38. Single-Cell Transcriptomics of Human TET2 Knockout CD4 T-Cells and Their Clonal Evolution

Author

Li, Yuping, primary, Liu, Xiaoqian, additional, Liu, Xuxiang, additional, Wu, Xiwei, additional, Bouska, Alyssa, additional, Lone, Waseem G., additional, Lio, Chan-Wang J., additional, Herek, Tyler, additional, Lee, Logan, additional, Dong, Gehong, additional, Wang, Jinhui, additional, Lou, Chih-Hong, additional, Qi, Wei, additional, Shetty, Kunal, additional, McKeithan, Timothy W., additional, Iqbal, Javeed, additional, and Chan, Wing (John) C., additional

Published
2020
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40. Genomic Characterization of Diffuse Large B-Cell Lymphoma Transformation from Nodular Lymphocyte Predominant Hodgkin Lymphoma

Author

Song, Joo Y., primary, Egan, Caoimhe, additional, Bouska, Alyssa, additional, Zhang, Weiwei, additional, Gong, Qiang, additional, Venkataraman, Girish, additional, Herrera, Alex F., additional, Chen, Lu, additional, Ottesen, Rebecca, additional, Niland, Joyce, additional, Bedell, Victoria, additional, Valle-Catuna, Maria, additional, Murata-Collins, Joyce, additional, Weisenburger, Dennis D., additional, Iqbal, Javeed, additional, Jaffe, Elaine S., additional, and Chan, Wing C., additional

Published
2019
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41. Genome-Wide microRNA Expression Profiling in Molecular Subgroups of Peripheral T-Cell Lymphoma Identified Role of Mir-126 in T-Cell Lymphomagenesis

Author

Lone, Waseem, primary, Bouska, Alyssa, additional, Herek, Tyler, additional, Amador, Catalina, additional, Saumyaranajn, Mallick, additional, Jiayu, Yu, additional, Heavican, Tayla, additional, Pileri, Stefano A., additional, McKeithan, Timothy, additional, Chan, Wing C., additional, and Iqbal, Javeed, additional

Published
2019
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42. Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma

Author

Ma, Man Chun John, primary, Tadros, Saber, additional, Bouska, Alyssa, additional, Heavican, Tayla, additional, Yang, Haopeng, additional, Deng, Qing, additional, Moore, Dalia, additional, Akhter, Ariz, additional, Hartert, Keenan, additional, Jain, Neeraj, additional, Showell, Jordan, additional, Ghosh, Sreejoyee, additional, Street, Lesley, additional, Davidson, Marta, additional, Carey, Christopher, additional, Tobin, Joshua, additional, Perumal, Deepak, additional, Vose, Julie M., additional, Lunning, Matthew A., additional, Sohani, Aliyah R., additional, Chen, Benjamin J., additional, Buckley, Shannon, additional, Nastoupil, Loretta J., additional, Davis, R. Eric, additional, Westin, Jason R., additional, Fowler, Nathan H., additional, Parekh, Samir, additional, Gandhi, Maher, additional, Neelapu, Sattva, additional, Stewart, Douglas, additional, Bhalla, Kapil, additional, Iqbal, Javeed, additional, Greiner, Timothy, additional, Rodig, Scott J., additional, Mansoor, Adnan, additional, and Green, Michael R., additional

Published
2019
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43. Targetable genetic alterations of TCF4 ( E2-2 ) drive immunoglobulin expression in diffuse large B cell lymphoma

Author

Jain, Neeraj, primary, Hartert, Keenan, additional, Tadros, Saber, additional, Fiskus, Warren, additional, Havranek, Ondrej, additional, Ma, Man Chun John, additional, Bouska, Alyssa, additional, Heavican, Tayla, additional, Kumar, Dhiraj, additional, Deng, Qing, additional, Moore, Dalia, additional, Pak, Christine, additional, Liu, Chih Long, additional, Gentles, Andrew J., additional, Hartmann, Elena, additional, Kridel, Robert, additional, Smedby, Karin Ekstrom, additional, Juliusson, Gunnar, additional, Rosenquist, Richard, additional, Gascoyne, Randy D., additional, Rosenwald, Andreas, additional, Giancotti, Filippo, additional, Neelapu, Sattva S., additional, Westin, Jason, additional, Vose, Julie M., additional, Lunning, Matthew A., additional, Greiner, Timothy, additional, Rodig, Scott, additional, Iqbal, Javeed, additional, Alizadeh, Ash A., additional, Davis, R. Eric, additional, Bhalla, Kapil, additional, and Green, Michael R., additional

Published
2019
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44. Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma

Author

Heavican, Tayla B., primary, Bouska, Alyssa, additional, Yu, Jiayu, additional, Lone, Waseem, additional, Amador, Catalina, additional, Gong, Qiang, additional, Zhang, Weiwei, additional, Li, Yuping, additional, Dave, Bhavana J., additional, Nairismägi, Maarja-Liisa, additional, Greiner, Timothy C., additional, Vose, Julie, additional, Weisenburger, Dennis D., additional, Lachel, Cynthia, additional, Wang, Chao, additional, Fu, Kai, additional, Stevens, Jadd M., additional, Lim, Soon Thye, additional, Ong, Choon Kiat, additional, Gascoyne, Randy D., additional, Missiaglia, Edoardo, additional, Lemonnier, Francois, additional, Haioun, Corinne, additional, Hartmann, Sylvia, additional, Pedersen, Martin Bjerregård, additional, Laginestra, Maria Antonella, additional, Wilcox, Ryan A., additional, Teh, Bin Tean, additional, Yoshida, Noriaki, additional, Ohshima, Koichi, additional, Seto, Masao, additional, Rosenwald, Andreas, additional, Ott, German, additional, Campo, Elias, additional, Rimsza, Lisa M., additional, Jaffe, Elaine S., additional, Braziel, Rita M., additional, d’Amore, Francesco, additional, Inghirami, Giorgio, additional, Bertoni, Francesco, additional, de Leval, Laurence, additional, Gaulard, Philippe, additional, Staudt, Louis M., additional, McKeithan, Timothy W., additional, Pileri, Stefano, additional, Chan, Wing C., additional, and Iqbal, Javeed, additional

Published
2019
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45. Phase I/II study of dasatinib and exploratory genomic analysis in relapsed or refractory non-Hodgkin lymphoma

Author

Umakanthan, Jayadev M., primary, Iqbal, Javeed, additional, Batlevi, Connie L., additional, Bouska, Alyssa, additional, Smith, Lynette M., additional, Shostrom, Valerie, additional, Nutsch, Heather, additional, William, Basem M., additional, Gregory Bociek, R., additional, Lunning, Matthew, additional, Bierman, Philip, additional, Younes, Anas, additional, Armitage, James O., additional, and Vose, Julie M., additional

Published
2018
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46. Final Analysis of the Front-Line Phase III Randomized ACT-1 Trial in Younger Patients with Systemic Peripheral T-Cell Lymphoma Treated with CHOP Chemotherapy with or without Alemtuzumab and Consolidated By Autologous Hematopoietic Stem Cell Transplant

Author

d'Amore, Francesco, primary, Leppä, Sirpa, additional, Silva, Maria Gomes da, additional, Relander, Thomas, additional, Lauritzsen, Grete Fossum, additional, Brown, Peter De Nully, additional, Pezzutto, Antonio, additional, Doorduijn, Jeanette K., additional, Weidmann, Eckhart, additional, van Gelder, Michel, additional, Hoof, Achiel Van, additional, Christiansen, Ilse, additional, Fagerli, Unn Merete, additional, Hagberg, Hans, additional, Lugtenburg, P.J., additional, Walewski, Jan, additional, Wu, Ka Lung, additional, Demuynck, Hilde Maria, additional, Fijnheer, Rob, additional, Christensen, Jacob H., additional, Jankovská, Milada, additional, Josefsson, Pär L., additional, Kluin-Nelemans, Hanneke, additional, Mariz, Jose Mario, additional, Merup, Mats A., additional, Noesslinger, Thomas, additional, Van Den Neste, Eric, additional, Zijlstra, Josée M, additional, Hopfinger, Georg, additional, Prochazka, VIT, additional, Jantunen, Esa, additional, Boudova, Ludmila, additional, Cabecadas, Jose, additional, Chott, Andreas, additional, Delabie, Jan M.A., additional, de Leval, Laurence, additional, Diepstra, Arjan, additional, Karjalainen-Lindsberg, Marja-Liisa, additional, Noergaard, Peter, additional, Rosenwald, Andreas, additional, Rymkiewicz, Grzegorz, additional, Sundström, Christer, additional, Truemper, Lorenz, additional, Wulf, Gerald, additional, Chong, Lauren, additional, Bouska, Alyssa, additional, Smith, Lynette, additional, Gisselbrecht, Christian, additional, Ziepert, Marita, additional, Loeffler, Markus, additional, Liestol, Knut, additional, Steidl, Christian, additional, Gascoyne, Randy D., additional, Scott, David W., additional, Altmann, Bettina, additional, Iqbal, Javeed, additional, Chan, Wing C, additional, and Toldbod, Helle, additional

Published
2018
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47. VAV1mutations contribute to development of T-cell neoplasms in mice

Author

Fukumoto, Kota, Sakata-Yanagimoto, Mamiko, Fujisawa, Manabu, Sakamoto, Tatsuhiro, Miyoshi, Hiroaki, Suehara, Yasuhito, Nguyen, Tran B., Suma, Sakurako, Yanagimoto, Shintaro, Shiraishi, Yuichi, Chiba, Kenichi, Bouska, Alyssa, Kataoka, Keisuke, Ogawa, Seishi, Iqbal, Javeed, Ohshima, Koichi, and Chiba, Shigeru

Abstract

Activating mutations in the Vav guanine nucleotide exchange factor 1 (VAV1) gene are reported in various subtypes of mature T-cell neoplasms (TCNs). However, oncogenic activities associated with VAV1mutations in TCNs remain unclear. To define them, we established transgenic mice expressing VAV1 mutants cloned from human TCNs. Although we observed no tumors in these mice for up to a year, tumors did develop in comparably aged mice on a p53-null background (p53−/−VAV1-Tg), and p53−/−VAV1-Tgmice died with shorter latencies than did p53-null (p53−/−) mice. Notably, various TCNs with tendency of maturation developed in p53−/−VAV1-Tgmice, whereas p53−/−mice exhibited only immature TCNs. Mature TCNs in p53−/−VAV1-Tgmice mimicked a subtype of human peripheral T-cell lymphoma (PTCL-GATA3) and exhibited features of type 2 T helper (Th2) cells. Phenotypes seen following transplantation of either p53−/−VAV1or p53−/−tumor cells into nude mice were comparable, indicating cell-autonomous tumor-initiating capacity. Whole-transcriptome analysis showed enrichment of multiple Myc-related pathways in TCNs from p53−/−VAV1-Tgmice relative to p53−/−or wild-type T cells. Remarkably, amplification of the Myclocus was found recurrently in TCNs of p53−/−VAV1-Tgmice. Finally, treatment of nude mice transplanted with p53−/−VAV1-Tgtumor cells with JQ1, a bromodomain inhibitor that targets the Myc pathway, prolonged survival of mice. We conclude that VAV1mutations function in malignant transformation of T cells in vivo and that VAV1-mutant–expressing mice could provide an efficient tool for screening new therapeutic targets in TCNs harboring these mutations.

Published
2020
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48. Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in the activated B-cell subtype of diffuse large B-cell lymphoma

Author

Jain, Neeraj, primary, Hartert, Keenan, additional, Tadros, Saber, additional, Fiskus, Warren, additional, Havranek, Ondrej, additional, John Ma, Man-Chun, additional, Bouska, Alyssa, additional, Heavican, Tayla, additional, Kumar, Dhiraj, additional, Deng, Qing, additional, Moore, Dalia, additional, Pak, Christine, additional, Liu, Chih Long, additional, Gentles, Andrew, additional, Hartmann, Elena, additional, Kridel, Robert, additional, Smedby, Karin Ekstrom, additional, Juliusson, Gunnar, additional, Rosenquist, Richard, additional, Gascoyne, Randy D., additional, Rosenwald, Andreas, additional, Giancotti, Filippo, additional, Neelapu, Sattva S., additional, Westin, Jason, additional, Vose, Julie, additional, Lunning, Matthew, additional, Greiner, Timothy, additional, Rodig, Scott, additional, Iqbal, Javeed, additional, Alizadeh, Ash, additional, Davis, R. Eric, additional, Bhalla, Kapil, additional, and Green, Michael R., additional

Published
2017
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