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This study was conducted at the ruminant station of the Technical Institute of Breeding Baba-Ali on the peri-partum period in ewes of the Rembi breed. It focused on the variations of some hematological and biochemical parameters of 7 ewes during 2 months (1 month before lambing and one month after). The blood samples were taken every 15 days, which were analyzed by blood count within the hour following the blood sampling, concerning the hematological parameters. Besides, for the biochemical parameters, the blood was centrifuged and the sera were frozen until the day of analysis. The results of the analysis using logicial R revealed nonsignificant variations (P >0.05) for the following parameters: White blood cells, Lymphocytes, Red blood cells, Hemoglobin, Hematocrit, and Blood platelets. These results are contradictory to the results obtained in previous studies except for a study conducted on ewes of the Lacaune breed. Regarding the biochemical parameters, the variation was significant (P<0.05) for cholesterol, urea, and creatinine, but not significant for calcium, glucose and triglycerides (P >0.05). The results obtained are debatable from the results quoted by several authors, except for creatinine which was found to be much higher. [ABSTRACT FROM AUTHOR]