Search

Your search keyword '"Bourquin, Jean‐Pierre"' showing total 854 results
Start Over Author "Bourquin, Jean‐Pierre"
854 results on '"Bourquin, Jean‐Pierre"'

1. Skin Cancer Induction by the Antimycotic Drug Voriconazole Is Caused by Impaired DNA Damage Detection Due to Chromatin Compaction

Author

Giovannini, Sara, Weibel, Lisa, Schittek, Birgit, Sinnberg, Tobias, Schaller, Martin, Lemberg, Christina, Fehrenbacher, Birgit, Biesemeier, Antje, Nordin, Renate, Ivanova, Irina, Kurz, Bernadett, Svilenska, Teodora, Berger, Christoph, Bourquin, Jean-Pierre, Kulik, Andreas, Fassihi, Hiva, Lehmann, Alan, Sarkany, Robert, Kobert, Nikita, van Toorn, Marvin, Marteijn, Jurgen A., French, Lars E., Rocken, Martin, Vermeulen, Wim, Kamenisch, York, and Berneburg, Mark

Published
2024
Full Text
View/download PDF

2. The IL-7R antagonist lusvertikimab reduces leukemic burden in xenograft ALL via antibody-dependent cellular phagocytosis

Author

Lenk, Lennart, Baccelli, Irène, Laqua, Anna, Heymann, Julia, Reimer, Claas, Dietterle, Anna, Winterberg, Dorothee, Mary, Caroline, Corallo, Frédérique, Taurelle, Julien, Narbeburu, Emma, Neyton, Stéphanie, Déramé, Mylène, Pengam, Sabrina, Vogiatzi, Fotini, Bornhauser, Beat, Bourquin, Jean-Pierre, Raffel, Simon, Dovhan, Vladyslava, Schüler, Thomas, Escherich, Gabriele, den Boer, Monique L., Boer, Judith M., Wessels, Wiebke, Peipp, Matthias, Alten, Julia, Antić, Željko, Bergmann, Anke K., Schrappe, Martin, Cario, Gunnar, Brüggemann, Monika, Poirier, Nicolas, and Schewe, Denis M.

Published
2024
Full Text
View/download PDF

3. The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG

Author

Kugler, Eitan, Madiwale, Shreyas, Yong, Darren, Thoms, Julie A. I., Birger, Yehudit, Sykes, David B., Schmoellerl, Johannes, Drakul, Aneta, Priebe, Valdemar, Yassin, Muhammad, Aqaqe, Nasma, Rein, Avigail, Fishman, Hila, Geron, Ifat, Chen, Chun-Wei, Raught, Brian, Liu, Qiao, Ogana, Heather, Liedke, Elisabeth, Bourquin, Jean-Pierre, Zuber, Johannes, Milyavsky, Michael, Pimanda, John, Privé, Gilbert G., and Izraeli, Shai

Published
2023
Full Text
View/download PDF

4. Functional analysis of structural variants in single cells using Strand-seq

Author

Jeong, Hyobin, Grimes, Karen, Rauwolf, Kerstin K., Bruch, Peter-Martin, Rausch, Tobias, Hasenfeld, Patrick, Benito, Eva, Roider, Tobias, Sabarinathan, Radhakrishnan, Porubsky, David, Herbst, Sophie A., Erarslan-Uysal, Büşra, Jann, Johann-Christoph, Marschall, Tobias, Nowak, Daniel, Bourquin, Jean-Pierre, Kulozik, Andreas E., Dietrich, Sascha, Bornhauser, Beat, Sanders, Ashley D., and Korbel, Jan O.

Published
2023
Full Text
View/download PDF

5. CD371-positive pediatric B-cell acute lymphoblastic leukemia: propensity to lineage switch and slow early response to treatment

Author

Buldini, Barbara, Varotto, Elena, Maurer-Granofszky, Margarita, Gaipa, Giuseppe, Schumich, Angela, Brüggemann, Monika, Mejstrikova, Ester, Cazzaniga, Giovanni, Hrusak, Ondrej, Szczepanowski, Monika, Scarparo, Pamela, Zimmermann, Martin, Strehl, Sabine, Schinnerl, Dagmar, Zaliova, Marketa, Karawajew, Leonid, Bourquin, Jean-Pierre, Feuerstein, Tamar, Cario, Gunnar, Alten, Julia, Möricke, Anja, Biffi, Alessandra, Parasole, Rosanna, Fagioli, Franca, Valsecchi, Maria Grazia, Biondi, Andrea, Locatelli, Franco, Attarbaschi, Andishe, Schrappe, Martin, Conter, Valentino, Basso, Giuseppe, and Dworzak, Michael N.

Published
2024
Full Text
View/download PDF

7. IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia

Author

Vervoort, Britt M. T., primary, Butler, Miriam, additional, Grünewald, Kari J.T., additional, Schenau, Dorette S. van Ingen, additional, Tee, Trisha M., additional, Lucas, Luc, additional, Huitema, Alwin D. R., additional, Boer, Judith M., additional, Bornhauser, Beat C., additional, Bourquin, Jean-Pierre, additional, Hoogerbrugge, Peter M., additional, Van der Velden, Vincent H.J., additional, Kuiper, Roland P., additional, Van der Meer, Laurens T., additional, and Van Leeuwen, Frank N., additional

Published
2024
Full Text
View/download PDF

8. Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution

Author

Richter-Pechańska, Paulina, Kunz, Joachim B., Rausch, Tobias, Erarslan-Uysal, Büşra, Bornhauser, Beat, Frismantas, Viktoras, Assenov, Yassen, Zimmermann, Martin, Happich, Margit, von Knebel-Doeberitz, Caroline, von Neuhoff, Nils, Köhler, Rolf, Stanulla, Martin, Schrappe, Martin, Cario, Gunnar, Escherich, Gabriele, Kirschner-Schwabe, Renate, Eckert, Cornelia, Avigad, Smadar, Pfister, Stefan M., Muckenthaler, Martina U., Bourquin, Jean-Pierre, Korbel, Jan O., and Kulozik, Andreas E.

Published
2022
Full Text
View/download PDF

9. CD19 CAR T-cells for pediatric relapsed acute lymphoblastic leukemia with active CNS involvement: a retrospective international study

Author

Jacoby, Elad, Ghorashian, Sara, Vormoor, Britta, De Moerloose, Barbara, Bodmer, Nicole, Molostova, Olga, Yanir, Asaf D, Buechner, Jochen, Elhasid, Ronit, Bielorai, Bella, Rogosic, Srdan, Dourthe, Marie-Emilie, Maschan, Michael, Rossig, Claudia, Toren, Amos, von Stackelberg, Arend, Locatelli, Franco, Bader, Peter, Zimmermann, Martin, Bourquin, Jean Pierre, and Baruchel, Andre

Published
2022
Full Text
View/download PDF

10. Correction: Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia

Author

Bhojwani, Deepa, Sposto, Richard, Shah, Nirali N, Rodriguez, Vilmarie, Yuan, Constance, Stetler-Stevenson, Maryalice, O’Brien, Maureen M, McNeer, Jennifer L, Quereshi, Amrana, Cabannes, Aurelie, Schlegel, Paul, Rossig, Claudia, Dalla-Pozza, Luciano, August, Keith, Alexander, Sarah, Bourquin, Jean-Pierre, Zwaan, Michel, Raetz, Elizabeth A, Loh, Mignon L, and Rheingold, Susan R

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Rare Diseases, Pediatric Cancer, Pediatric, Good Health and Well Being, Immunology, Cardiovascular medicine and haematology, Clinical sciences, Oncology and carcinogenesis
Abstract

We thank the research coordinators and following physicians at pediatric cancer centers for contributing data to this project: Prashant Hiwarkar and Jayashree Motwani, Birmingham Women's and Children's Hospital, UK; Kelly Malone, Children's Hospital of Colorado, USA; Mylene Bassal, Children's Hospital of Eastern Ontario, Canada; Yoav Messinger and Joanna Perkins, Children's Hospital of Minnesota, USA; Van Huynh, Children's Hospital of Orange County, USA; Richard Ho, Children's Hospital at Vanderbilt, USA; Joanne Chuah and Jessa Morales, Children's Hospital at Westmead, Australia; Donald Wells, Dell Children's Hospital, USA; Nicolas Boissel, Hospital Saint-Louis, France; Tannie Huang, Kaiser Permanente, USA; Stacey Marjerrison, McMaster Children's Hospital, Canada; William Carroll and Joanna Pierro, New York University Langone Medical Center, USA; Ajay Vora, Sheffield Children's Hospital, UK; Donna Lancaster, The Royal Marsden Hospital, UK; Lucie Šrámková, University Hospital Motol, Czech Republic; Chatchawin Assanasen, University of Texas Health Science Center, San Antonio, USA; Rupert Handgretinger, University of Tübingen, Germany.

Published
2019

11. Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia

Author

Bhojwani, Deepa, Sposto, Richard, Shah, Nirali N, Rodriguez, Vilmarie, Yuan, Constance, Stetler-Stevenson, Maryalice, O’Brien, Maureen M, McNeer, Jennifer L, Quereshi, Amrana, Cabannes, Aurelie, Schlegel, Paul, Rossig, Claudia, Dalla-Pozza, Luciano, August, Keith, Alexander, Sarah, Bourquin, Jean-Pierre, Zwaan, Michel, Raetz, Elizabeth A, Loh, Mignon L, and Rheingold, Susan R

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Pediatric Research Initiative, Childhood Leukemia, Rare Diseases, Stem Cell Research, Cancer, Pediatric, Hematology, Transplantation, Clinical Research, Pediatric Cancer, Adolescent, Adult, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Child, Child, Preschool, Drug Resistance, Neoplasm, Female, Humans, Inotuzumab Ozogamicin, Male, Neoplasm Recurrence, Local, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Remission Induction, Retrospective Studies, Salvage Therapy, Survival Rate, Young Adult, Clinical Sciences, Immunology, Cardiovascular medicine and haematology, Clinical sciences, Oncology and carcinogenesis
Abstract

Although inotuzumab ozogamicin (InO) is recognized as an effective agent in relapsed acute lymphoblastic leukemia (ALL) in adults, data on safety and efficacy in pediatric patients are scarce. We report the use of InO in 51 children with relapsed/refractory ALL treated in the compassionate use program. In this heavily pretreated cohort, complete remission was achieved in 67% of patients with overt marrow disease. The majority (71%) of responders were negative for minimal residual disease. Responses were observed irrespective of cytogenetic subtype or number or type of prior treatment regimens. InO was well-tolerated; grade 3 hepatic transaminitis or hyperbilirubinemia were noted in 6 (12%) and grade 3/4 infections in 11 (22%) patients. No patient developed sinusoidal obstruction syndrome (SOS) during InO therapy; however, 11 of 21 (52%) patients who underwent hematopoietic stem cell transplantation (HSCT) following InO developed SOS. Downregulation of surface CD22 was detected as a possible escape mechanism in three patients who developed a subsequent relapse after InO. We conclude that InO is a well-tolerated, effective therapy for children with relapsed ALL and prospective studies are warranted. Identification of risk factors for developing post-HSCT SOS and strategies to mitigate this risk are ongoing.

Published
2019

12. Tisagenlecleucel therapy for relapsed or refractory B-cell acute lymphoblastic leukaemia in infants and children younger than 3 years of age at screening: an international, multicentre, retrospective cohort study

Author

Ghorashian, Sara, Jacoby, Elad, De Moerloose, Barbara, Rives, Susana, Bonney, Denise, Shenton, Geoff, Bader, Peter, Bodmer, Nicole, Quintana, Agueda Molinos, Herrero, Blanca, Algeri, Mattia, Locatelli, Franco, Vettenranta, Kim, Gonzalez, Berta, Attarbaschi, Andishe, Harris, Stephen, Bourquin, Jean Pierre, and Baruchel, André

Published
2022
Full Text
View/download PDF

13. Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies by augmenting tumor cell phagocytosis

Author

Vogiatzi, Fotini, Heymann, Julia, Müller, Kristina, Winterberg, Dorothee, Drakul, Aneta, Rösner, Thies, Lenk, Lennart, Heib, Michelle, Gehlert, Carina Lynn, Cario, Gunnar, Schrappe, Martin, Claviez, Alexander, Bornhauser, Beat, Bourquin, Jean-Pierre, Bomken, Simon, Adam, Dieter, Frielitz, Fabian-Simon, Maecker-Kolhoff, Britta, Stanulla, Martin, Valerius, Thomas, Peipp, Matthias, Kellner, Christian, and Schewe, Denis M.

Published
2022
Full Text
View/download PDF

14. Combining daratumumab with CD47 blockade prolongs survival in preclinical models of pediatric T-ALL

Author

Müller, Kristina, Vogiatzi, Fotini, Winterberg, Dorothee, Rösner, Thies, Lenk, Lennart, Bastian, Lorenz, Gehlert, Carina L., Autenrieb, Marie-Pauline, Brüggemann, Monika, Cario, Gunnar, Schrappe, Martin, Kulozik, Andreas E., Eckert, Cornelia, Bergmann, Anke K., Bornhauser, Beat, Bourquin, Jean-Pierre, Valerius, Thomas, Peipp, Matthias, Kellner, Christian, and Schewe, Denis M.

Published
2022
Full Text
View/download PDF

16. MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance

Author

van der Zwet, Jordy C. G., Buijs-Gladdines, Jessica G. C. A. M., Cordo’, Valentina, Debets, Donna O., Smits, Willem K., Chen, Zhongli, Dylus, Jelle, Zaman, Guido J. R., Altelaar, Maarten, Oshima, Koichi, Bornhauser, Beat, Bourquin, Jean-Pierre, Cools, Jan, Ferrando, Adolfo A., Vormoor, Josef, Pieters, Rob, Vormoor, Britta, and Meijerink, Jules P. P.

Published
2021
Full Text
View/download PDF

17. Pharmacological disruption of the Notch transcription factor complex

Author

Lehal, Rajwinder, Zaric, Jelena, Vigolo, Michele, Urech, Charlotte, Frismantas, Viktoras, Zangger, Nadine, Cao, Linlin, Berger, Adeline, Chicote, Irene, Loubéry, Sylvain, Choi, Sung Hee, Koch, Ute, Blacklow, Stephen C., Palmer, Hector G., Bornhauser, Beat, González-Gaitán, Marcos, Arsenijevic, Yvan, Zoete, Vincent, Aster, Jon C., Bourquin, Jean-Pierre, and Radtke, Freddy

Published
2020

18. Bosutinib in Resistant and Intolerant Pediatric Patients With Chronic Phase Chronic Myeloid Leukemia: Results From the Phase I Part of Study ITCC054/COG AAML1921

Author

Apotheek O&O&O, Cancer, Brivio, Erica, Pennesi, Edoardo, Willemse, Marieke E, Huitema, Alwin D R, Jiang, Yilin, van Tinteren, Harm D R, van der Velden, Vincent H J, Beverloo, Berna H, den Boer, Monique L, Rammeloo, Lukas A J, Hudson, Chad, Heerema, Nyla, Kowalski, Karey, Zhao, Huadong, Kuttschreuter, Luke, Bautista Sirvent, Francisco J, Bukowinski, Andrew, Rizzari, Carmelo, Pollard, Jessica, Murillo-Sanjuán, Laura, Kutny, Matthew, Zarnegar-Lumley, Sara, Redell, Michele, Cooper, Stacy, Bertrand, Yves, Petit, Arnaud, Krystal, Julie, Metzler, Markus, Lancaster, Donna, Bourquin, Jean-Pierre, Motwani, Jayashree, van der Sluis, Inge M, Locatelli, Franco, Roth, Michael E, Hijiya, Nobuko, Zwaan, Christian M, Apotheek O&O&O, Cancer, Brivio, Erica, Pennesi, Edoardo, Willemse, Marieke E, Huitema, Alwin D R, Jiang, Yilin, van Tinteren, Harm D R, van der Velden, Vincent H J, Beverloo, Berna H, den Boer, Monique L, Rammeloo, Lukas A J, Hudson, Chad, Heerema, Nyla, Kowalski, Karey, Zhao, Huadong, Kuttschreuter, Luke, Bautista Sirvent, Francisco J, Bukowinski, Andrew, Rizzari, Carmelo, Pollard, Jessica, Murillo-Sanjuán, Laura, Kutny, Matthew, Zarnegar-Lumley, Sara, Redell, Michele, Cooper, Stacy, Bertrand, Yves, Petit, Arnaud, Krystal, Julie, Metzler, Markus, Lancaster, Donna, Bourquin, Jean-Pierre, Motwani, Jayashree, van der Sluis, Inge M, Locatelli, Franco, Roth, Michael E, Hijiya, Nobuko, and Zwaan, Christian M

Published
2024

19. Bosutinib in Resistant and Intolerant Pediatric Patients With Chronic Phase Chronic Myeloid Leukemia:Results From the Phase I Part of Study ITCC054/COG AAML1921

Author

Brivio, Erica, Pennesi, Edoardo, Willemse, Marieke E., Huitema, Alwin D.R., Jiang, Yilin, Van Tinteren, Harm D.R., Van Der Velden, Vincent H.J., Beverloo, Berna H., Den Boer, Monique L., Rammeloo, Lukas A.J., Hudson, Chad, Heerema, Nyla, Kowalski, Karey, Zhao, Huadong, Kuttschreuter, Luke, Bautista Sirvent, Francisco J., Bukowinski, Andrew, Rizzari, Carmelo, Pollard, Jessica, Murillo-Sanjuán, Laura, Kutny, Matthew, Zarnegar-Lumley, Sara, Redell, Michele, Cooper, Stacy, Bertrand, Yves, Petit, Arnaud, Krystal, Julie, Metzler, Markus, Lancaster, Donna, Bourquin, Jean Pierre, Motwani, Jayashree, Van Der Sluis, Inge M., Locatelli, Franco, Roth, Michael E., Hijiya, Nobuko, Zwaan, Christian M., Brivio, Erica, Pennesi, Edoardo, Willemse, Marieke E., Huitema, Alwin D.R., Jiang, Yilin, Van Tinteren, Harm D.R., Van Der Velden, Vincent H.J., Beverloo, Berna H., Den Boer, Monique L., Rammeloo, Lukas A.J., Hudson, Chad, Heerema, Nyla, Kowalski, Karey, Zhao, Huadong, Kuttschreuter, Luke, Bautista Sirvent, Francisco J., Bukowinski, Andrew, Rizzari, Carmelo, Pollard, Jessica, Murillo-Sanjuán, Laura, Kutny, Matthew, Zarnegar-Lumley, Sara, Redell, Michele, Cooper, Stacy, Bertrand, Yves, Petit, Arnaud, Krystal, Julie, Metzler, Markus, Lancaster, Donna, Bourquin, Jean Pierre, Motwani, Jayashree, Van Der Sluis, Inge M., Locatelli, Franco, Roth, Michael E., Hijiya, Nobuko, and Zwaan, Christian M.

Abstract

PURPOSE Bosutinib is approved for adults with chronic myeloid leukemia (CML): 400 mg once daily in newly diagnosed (ND); 500 mg once daily in resistant/intolerant (R/I) patients. Bosutinib has a different tolerability profile than other tyrosine kinase inhibitors (TKIs) and potentially less impact on growth (preclinical data). The primary objective of this first-in-child trial was to determine the recommended phase II dose (RP2D) for pediatric R/I and ND patients. PATIENTS AND METHODS In the phase I part of this international, open-label trial (ClinicalTrials.gov identifier: NCT04258943), children age 1-18 years with R/I (per European LeukemiaNet 2013) Ph+ CML were enrolled using a 6 + 4 design, testing 300, 350, and 400 mg/m2 once daily with food. The RP2D was the dose resulting in 0/6 or 1/10 dose-limiting toxicities (DLTs) during the first cycle and achieving adult target AUC levels for the respective indication. As ND participants were only enrolled in phase II, the ND RP2D was selected based on data from R/I patients. Results Thirty patients were enrolled; 27 were evaluable for DLT: six at 300 mg/m2, 11 at 350 mg/m2 (one DLT), and 10 at 400 mg/m2 (one DLT). The mean AUCs at 300 mg/m2, 350 mg/m2, and 400 mg/m2 were 2.20 g h/mL, 2.52 g h/mL, and 2.66 g h/mL, respectively. The most common adverse event was diarrhea (93%; ≥grade 3: 11%). Seven patients stopped because of intolerance and eight because of insufficient response. Complete cytogenetic and major molecular response to bosutinib appeared comparable with other published phase I/II trials with second-generation TKIs in children. CONCLUSION Bosutinib was safe and effective. The pediatric RP2D was 400 mg/m2 once daily (max 600 mg/d) with food in R/I patients and 300 mg/m2 once daily (max 500 mg/d) with food in ND patients, which achieved targeted exposures as per adult experience.

Published
2024

21. Approaches for bridging therapy prior to chimeric antigen receptor T cells for relapsed/refractory acute lymphoblastic B-lineage leukaemia in children and young adults

Author

Feuchtinger, Tobias, primary, Bader, Peter, additional, Subklewe, Marion, additional, Breidenbach, Maike, additional, Willier, Semjon, additional, Metzler, Markus, additional, Gökbuget, Nicola, additional, Hauer, Julia, additional, Müller, Fabian, additional, Schlegel, Paul-Gerhardt, additional, Frühwald, Michael, additional, Schmid, Christoph, additional, Troeger, Anja, additional, Baldus, Claudia, additional, Meisel, Roland, additional, Künkele, Annette, additional, Topp, Max, additional, Bourquin, Jean-Pierre, additional, Cario, Gunnar, additional, Von Stackelberg, Arend, additional, and Peters, Christina, additional

Published
2024
Full Text
View/download PDF

22. Single-cell analysis of structural variations and complex rearrangements with tri-channel processing

Author

Sanders, Ashley D., Meiers, Sascha, Ghareghani, Maryam, Porubsky, David, Jeong, Hyobin, van Vliet, M. Alexandra C. C., Rausch, Tobias, Richter-Pechańska, Paulina, Kunz, Joachim B., Jenni, Silvia, Bolognini, Davide, Longo, Gabriel M. C., Raeder, Benjamin, Kinanen, Venla, Zimmermann, Jürgen, Benes, Vladimir, Schrappe, Martin, Mardin, Balca R., Kulozik, Andreas E., Bornhauser, Beat, Bourquin, Jean-Pierre, Marschall, Tobias, and Korbel, Jan O.

Published
2020
Full Text
View/download PDF

24. Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets

Author

Hoell, Jessica I., Ginzel, Sebastian, Kuhlen, Michaela, Kloetgen, Andreas, Gombert, Michael, Fischer, Ute, Hein, Daniel, Demir, Salih, Stanulla, Martin, Schrappe, Martin, zur Stadt, Udo, Bader, Peter, Babor, Florian, Schuster, Friedhelm, Strahm, Brigitte, Alten, Julia, Moericke, Anja, Escherich, Gabriele, von Stackelberg, Arend, Thiele, Ralf, McHardy, Alice C., Peters, Christina, Bornhauser, Beat, Bourquin, Jean-Pierre, Krause, Stefan, Enczmann, Juergen, Meyer, Lüder Hinrich, Eckert, Cornelia, Borkhardt, Arndt, and Meisel, Roland

Published
2019
Full Text
View/download PDF

28. Guidelines for the use and interpretation of assays for monitoring autophagy.

Author

Klionsky, Daniel J, Abdalla, Fabio C, Abeliovich, Hagai, Abraham, Robert T, Acevedo-Arozena, Abraham, Adeli, Khosrow, Agholme, Lotta, Agnello, Maria, Agostinis, Patrizia, Aguirre-Ghiso, Julio A, Ahn, Hyung Jun, Ait-Mohamed, Ouardia, Ait-Si-Ali, Slimane, Akematsu, Takahiko, Akira, Shizuo, Al-Younes, Hesham M, Al-Zeer, Munir A, Albert, Matthew L, Albin, Roger L, Alegre-Abarrategui, Javier, Aleo, Maria Francesca, Alirezaei, Mehrdad, Almasan, Alexandru, Almonte-Becerril, Maylin, Amano, Atsuo, Amaravadi, Ravi, Amarnath, Shoba, Amer, Amal O, Andrieu-Abadie, Nathalie, Anantharam, Vellareddy, Ann, David K, Anoopkumar-Dukie, Shailendra, Aoki, Hiroshi, Apostolova, Nadezda, Arancia, Giuseppe, Aris, John P, Asanuma, Katsuhiko, Asare, Nana YO, Ashida, Hisashi, Askanas, Valerie, Askew, David S, Auberger, Patrick, Baba, Misuzu, Backues, Steven K, Baehrecke, Eric H, Bahr, Ben A, Bai, Xue-Yuan, Bailly, Yannick, Baiocchi, Robert, Baldini, Giulia, Balduini, Walter, Ballabio, Andrea, Bamber, Bruce A, Bampton, Edward TW, Bánhegyi, Gábor, Bartholomew, Clinton R, Bassham, Diane C, Bast, Robert C, Batoko, Henri, Bay, Boon-Huat, Beau, Isabelle, Béchet, Daniel M, Begley, Thomas J, Behl, Christian, Behrends, Christian, Bekri, Soumeya, Bellaire, Bryan, Bendall, Linda J, Benetti, Luca, Berliocchi, Laura, Bernardi, Henri, Bernassola, Francesca, Besteiro, Sébastien, Bhatia-Kissova, Ingrid, Bi, Xiaoning, Biard-Piechaczyk, Martine, Blum, Janice S, Boise, Lawrence H, Bonaldo, Paolo, Boone, David L, Bornhauser, Beat C, Bortoluci, Karina R, Bossis, Ioannis, Bost, Frédéric, Bourquin, Jean-Pierre, Boya, Patricia, Boyer-Guittaut, Michaël, Bozhkov, Peter V, Brady, Nathan R, Brancolini, Claudio, Brech, Andreas, Brenman, Jay E, Brennand, Ana, Bresnick, Emery H, Brest, Patrick, Bridges, Dave, Bristol, Molly L, Brookes, Paul S, Brown, Eric J, and Brumell, John H

Subjects
Animals, Humans, Biological Assay, Models, Biological, Autophagy, Generic health relevance, autolysosome, autophagosome, flux, LC3, lysosome, phagophore, stress, vacuole, Biochemistry and Cell Biology, Biochemistry & Molecular Biology
Abstract

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.

Published
2012

31. P316: PRIORITIZING PRECISION MEDICINES IN PEDIATRIC BLOOD CANCER: EXPERIENCE OF THE DUTCH INDIVIDUALIZED THERAPY (ITHER) STUDY’S MOLECULAR TUMOR BOARD

Author

Boer, Judith M., primary, Ilan, Uri, additional, Hoen, Babette D.J., additional, Boeree, Aurelie, additional, Langenberg, Karin P.S., additional, Koster, Jan, additional, Bourquin, Jean-Pierre, additional, Molenaar, Jan J., additional, Goemans, Bianca, additional, den Boer, Monique L., additional, and Zwaan, Michel, additional

Published
2023
Full Text
View/download PDF

32. P330: PROTEOMIC PROFILING UNCOVERS THERAPEUTIC VULNERABILITIES FOR TCF3 TRANSLOCATED B-CELL ACUTE LYMPHOBLASTIC LEUKEMIAS

Author

Hasselmann, Rebecca, primary, Blümel, Lena, additional, Bernardi, Flavia, additional, Picard, Daniel, additional, Torrejon-Diaz, Jacob, additional, Jepsen, Vera, additional, Bartl, Jasmin, additional, Qin, Nan, additional, Bornhauser, Beat, additional, Bhatia, Sanil, additional, Marovca, Blerim, additional, Marsaud, Veronique, additional, Dingli, Florent, additional, Loew, Damarys, additional, Stanulla, Martin, additional, Bourquin, Jean-Pierre, additional, Borkhardt, Arndt, additional, Remke, Marc, additional, Ayrault, Olivier, additional, and Fischer, Ute, additional

Published
2023
Full Text
View/download PDF

33. S111: TREATMENT OF POST-TRANSPLANT RELAPSE IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS WITH BCP ALL USING CD19-CAR-T: A EUROPEAN RETROSPECTIVE ANALYSIS OF REAL-WORLD DATA

Author

Bader, Peter, primary, Alsonso, Anna, additional, Attarbaschi, Andishe, additional, Bodmer, Nicole, additional, Bonig, Halvard, additional, Burridge, Saskia, additional, Bourquin, Jean-Pierre, additional, Bücklein, Veit, additional, Cario, Gunnar, additional, Oporto Espuelas, Macarena, additional, Feuhtinger, Tobias, additional, Fuereder, Anna, additional, Hauer, Julia, additional, Hutter, Martin, additional, Kałwak, Krzysztof, additional, Künkele, Annette, additional, Meisel, Roland, additional, Mielcarek-Siedziuk, Monika, additional, Müller, Ingo, additional, Napolitano, Sara, additional, Penack, Olaf, additional, Rives, Susana, additional, Rossig, Claudia, additional, von Stackelberg, Arend, additional, Jarisch, Andrea, additional, Ghorashian, Sara, additional, and Balduzzi, Adriana, additional

Published
2023
Full Text
View/download PDF

34. P676: UPDATED RESULTS FROM THE TRIAL ITCC-054/COG-AAML1921: BOSUTINIB IN NEWLY DIAGNOSED AND RESISTANT/INTOLERANT PEDIATRIC PATIENTS WITH CHRONIC MYELOID LEUKEMIA

Author

Brivio, Erica, primary, Pennesi, Edoardo, additional, Willemse, Marieke, additional, Jiang, Yilin, additional, van der Velden, Vincent, additional, Beverloo, Berna, additional, Hudson, Chad, additional, Kuttschreuter, Luke, additional, van der Sluis, Inge, additional, Brethon, Benoît, additional, Bautista, Francisco, additional, J. Burke, Michael, additional, Heerema, Nyla, additional, Bukowinski, Andrew, additional, Cooper, Stacy, additional, Pollard, Jessica, additional, Nagasubramani, Ramamoorthy, additional, Redell, Michele, additional, Bourquin, Jean-Pierre, additional, Pais, Ray, additional, Frediani, Jamie, additional, Batra, Sandeep, additional, Bertorello, Nicoletta, additional, Boklan, Jessica, additional, Kheradpour, Albert, additional, Kyono, Wade, additional, Kowalski, Karey, additional, Mizukawa, Benjamin, additional, Lancaster, Donna, additional, Murillo-Sanjuán, Laura, additional, Krystal, Julie, additional, Bertrand, Yves, additional, Huitema, Alwin, additional, van Tinteren, Harm, additional, Locatelli, Franco, additional, Roth, Michael, additional, Hijiya, Nobuko, additional, and Zwaan, Michel, additional

Published
2023
Full Text
View/download PDF

36. From class waivers to precision medicine in paediatric oncology

Author

Pearson, Andrew D J, Pfister, Stefan M, Baruchel, Andre, Bourquin, Jean-Pierre, Casanova, Michela, Chesler, Louis, Doz, François, Eggert, Angelika, Geoerger, Birgit, Jones, David T W, Kearns, Pamela R, Molenaar, Jan J, Morland, Bruce, Schleiermacher, Gudrun, Schulte, Johannes H, Vormoor, Josef, Marshall, Lynley V, Zwaan, C Michel, and Vassal, Gilles

Published
2017
Full Text
View/download PDF

37. Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

Author

Frismantas, Viktoras, Dobay, Maria Pamela, Rinaldi, Anna, Tchinda, Joelle, Dunn, Samuel H., Kunz, Joachim, Richter-Pechanska, Paulina, Marovca, Blerim, Pail, Orrin, Jenni, Silvia, Diaz-Flores, Ernesto, Chang, Bill H., Brown, Timothy J., Collins, Robert H., Uhrig, Sebastian, Balasubramanian, Gnana P., Bandapalli, Obul R., Higi, Salome, Eugster, Sabrina, Voegeli, Pamela, Delorenzi, Mauro, Cario, Gunnar, Loh, Mignon L., Schrappe, Martin, Stanulla, Martin, Kulozik, Andreas E., Muckenthaler, Martina U., Saha, Vaskar, Irving, Julie A., Meisel, Roland, Radimerski, Thomas, Von Stackelberg, Arend, Eckert, Cornelia, Tyner, Jeffrey W., Horvath, Peter, Bornhauser, Beat C., and Bourquin, Jean-Pierre

Published
2017
Full Text
View/download PDF

38. Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors

Author

Erarslan‐Uysal, Büşra, Kunz, Joachim B, Rausch, Tobias, Richter‐Pechańska, Paulina, van Belzen, Ianthe AEM, Frismantas, Viktoras, Bornhauser, Beat, Ordoñez‐Rueada, Diana, Paulsen, Malte, Benes, Vladimir, Stanulla, Martin, Schrappe, Martin, Cario, Gunnar, Escherich, Gabriele, Bakharevich, Kseniya, Kirschner‐Schwabe, Renate, Eckert, Cornelia, Loukanov, Tsvetomir, Gorenflo, Matthias, Waszak, Sebastian M, Bourquin, Jean‐Pierre, Muckenthaler, Martina U, Korbel, Jan O, and Kulozik, Andreas E

Published
2020
Full Text
View/download PDF

40. Repurposing anthelmintic agents to eradicate resistant leukemia

Author

Mezzatesta, Caterina, Abduli, Liridon, Guinot, Anna, Eckert, Cornelia, Schewe, Denis, Zaliova, Marketa, Vinti, Luciana, Marovca, Blerim, Tsai, Yi-Chien, Jenni, Silvia, Aguade-Gorgorio, Julia, von Stackelberg, Arend, Schrappe, Martin, Locatelli, Franco, Stanulla, Martin, Cario, Gunnar, Bourquin, Jean-Pierre, and Bornhauser, Beat C.

Published
2020
Full Text
View/download PDF

43. Abstract 2957: CD127 is expressed by acute lymphoblastic leukemias and is efficiently targeted by the IL7R-antagonist OSE-127 through macrophage-mediated antibody dependent phagocytosis

Author

Baccelli, Irene, primary, Lenk, Lennart, additional, Laqua, Anna, additional, Winterberg, Dorothee, additional, Dietterle, Anna, additional, Corallo, Frederique, additional, Taurelle, Julien, additional, Narbeburu, Emma, additional, Bornhauser, Beat, additional, Bourquin, Jean-Pierre, additional, Vogiatzi, Fotini, additional, Raffel, Simon, additional, Schrappe, Martin, additional, Cario, Gunnar, additional, Brüggemann, Monika, additional, Schewe, Denis M, additional, and Poirier, Nicolas, additional

Published
2023
Full Text
View/download PDF

44. Data Supplement from Cell and Molecular Determinants of In Vivo Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts

Author

Suryani, Santi, primary, Carol, Hernan, primary, Chonghaile, Triona Ni, primary, Frismantas, Viktoras, primary, Sarmah, Chintanu, primary, High, Laura, primary, Bornhauser, Beat, primary, Cowley, Mark J., primary, Szymanska, Barbara, primary, Evans, Kathryn, primary, Boehm, Ingrid, primary, Tonna, Elise, primary, Jones, Luke, primary, Manesh, Donya Moradi, primary, Kurmasheva, Raushan T., primary, Billups, Catherine, primary, Kaplan, Warren, primary, Letai, Anthony, primary, Bourquin, Jean-Pierre, primary, Houghton, Peter J., primary, Smith, Malcolm A., primary, and Lock, Richard B., primary

Published
2023
Full Text
View/download PDF

45. Supplementary Data from Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia

Author

Laurent, Anouchka P., primary, Siret, Aurélie, primary, Ignacimouttou, Cathy, primary, Panchal, Kunjal, primary, Diop, M'Boyba, primary, Jenni, Silvia, primary, Tsai, Yi-Chien, primary, Roos-Weil, Damien, primary, Aid, Zakia, primary, Prade, Nais, primary, Lagarde, Stephanie, primary, Plassard, Damien, primary, Pierron, Gaelle, primary, Daudigeos, Estelle, primary, Lecluse, Yann, primary, Droin, Nathalie, primary, Bornhauser, Beat C., primary, Cheung, Laurence C., primary, Crispino, John D., primary, Gaudry, Muriel, primary, Bernard, Olivier A., primary, Macintyre, Elizabeth, primary, Barin Bonnigal, Carole, primary, Kotecha, Rishi S., primary, Geoerger, Birgit, primary, Ballerini, Paola, primary, Bourquin, Jean-Pierre, primary, Delabesse, Eric, primary, Mercher, Thomas, primary, and Malinge, Sebastien, primary

Published
2023
Full Text
View/download PDF

46. Figure S3 from Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia

Author

Laurent, Anouchka P., primary, Siret, Aurélie, primary, Ignacimouttou, Cathy, primary, Panchal, Kunjal, primary, Diop, M'Boyba, primary, Jenni, Silvia, primary, Tsai, Yi-Chien, primary, Roos-Weil, Damien, primary, Aid, Zakia, primary, Prade, Nais, primary, Lagarde, Stephanie, primary, Plassard, Damien, primary, Pierron, Gaelle, primary, Daudigeos, Estelle, primary, Lecluse, Yann, primary, Droin, Nathalie, primary, Bornhauser, Beat C., primary, Cheung, Laurence C., primary, Crispino, John D., primary, Gaudry, Muriel, primary, Bernard, Olivier A., primary, Macintyre, Elizabeth, primary, Barin Bonnigal, Carole, primary, Kotecha, Rishi S., primary, Geoerger, Birgit, primary, Ballerini, Paola, primary, Bourquin, Jean-Pierre, primary, Delabesse, Eric, primary, Mercher, Thomas, primary, and Malinge, Sebastien, primary

Published
2023
Full Text
View/download PDF

47. Supplementary Table 6 from Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia

Author

Laurent, Anouchka P., primary, Siret, Aurélie, primary, Ignacimouttou, Cathy, primary, Panchal, Kunjal, primary, Diop, M'Boyba, primary, Jenni, Silvia, primary, Tsai, Yi-Chien, primary, Roos-Weil, Damien, primary, Aid, Zakia, primary, Prade, Nais, primary, Lagarde, Stephanie, primary, Plassard, Damien, primary, Pierron, Gaelle, primary, Daudigeos, Estelle, primary, Lecluse, Yann, primary, Droin, Nathalie, primary, Bornhauser, Beat C., primary, Cheung, Laurence C., primary, Crispino, John D., primary, Gaudry, Muriel, primary, Bernard, Olivier A., primary, Macintyre, Elizabeth, primary, Barin Bonnigal, Carole, primary, Kotecha, Rishi S., primary, Geoerger, Birgit, primary, Ballerini, Paola, primary, Bourquin, Jean-Pierre, primary, Delabesse, Eric, primary, Mercher, Thomas, primary, and Malinge, Sebastien, primary

Published
2023
Full Text
View/download PDF

48. Supplementary Table 5 from Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia

Author

Laurent, Anouchka P., primary, Siret, Aurélie, primary, Ignacimouttou, Cathy, primary, Panchal, Kunjal, primary, Diop, M'Boyba, primary, Jenni, Silvia, primary, Tsai, Yi-Chien, primary, Roos-Weil, Damien, primary, Aid, Zakia, primary, Prade, Nais, primary, Lagarde, Stephanie, primary, Plassard, Damien, primary, Pierron, Gaelle, primary, Daudigeos, Estelle, primary, Lecluse, Yann, primary, Droin, Nathalie, primary, Bornhauser, Beat C., primary, Cheung, Laurence C., primary, Crispino, John D., primary, Gaudry, Muriel, primary, Bernard, Olivier A., primary, Macintyre, Elizabeth, primary, Barin Bonnigal, Carole, primary, Kotecha, Rishi S., primary, Geoerger, Birgit, primary, Ballerini, Paola, primary, Bourquin, Jean-Pierre, primary, Delabesse, Eric, primary, Mercher, Thomas, primary, and Malinge, Sebastien, primary

Published
2023
Full Text
View/download PDF

49. Supplementary Table 2 from USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia

Author

Jin, Qi, primary, Martinez, Carlos A., primary, Arcipowski, Kelly M., primary, Zhu, Yixing, primary, Gutierrez-Diaz, Blanca T., primary, Wang, Kenneth K., primary, Johnson, Megan R., primary, Volk, Andrew G., primary, Wang, Feng, primary, Wu, Jian, primary, Grove, Charles, primary, Wang, Hui, primary, Sokirniy, Ivan, primary, Thomas, Paul M., primary, Goo, Young Ah, primary, Abshiru, Nebiyu A., primary, Hijiya, Nobuko, primary, Peirs, Sofie, primary, Vandamme, Niels, primary, Berx, Geert, primary, Goosens, Steven, primary, Marshall, Stacy A., primary, Rendleman, Emily J., primary, Takahashi, Yoh-hei, primary, Wang, Lu, primary, Rawat, Radhika, primary, Bartom, Elizabeth T., primary, Collings, Clayton K., primary, Van Vlierberghe, Pieter, primary, Strikoudis, Alexandros, primary, Kelly, Stephen, primary, Ueberheide, Beatrix, primary, Mantis, Christine, primary, Kandela, Irawati, primary, Bourquin, Jean-Pierre, primary, Bornhauser, Beat, primary, Serafin, Valentina, primary, Bresolin, Silvia, primary, Paganin, Maddalena, primary, Accordi, Benedetta, primary, Basso, Giuseppe, primary, Kelleher, Neil L., primary, Weinstock, Joseph, primary, Kumar, Suresh, primary, Crispino, John D., primary, Shilatifard, Ali, primary, and Ntziachristos, Panagiotis, primary

Published
2023
Full Text
View/download PDF

50. Supplementary Table 3 from Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia

Author

Laurent, Anouchka P., primary, Siret, Aurélie, primary, Ignacimouttou, Cathy, primary, Panchal, Kunjal, primary, Diop, M'Boyba, primary, Jenni, Silvia, primary, Tsai, Yi-Chien, primary, Roos-Weil, Damien, primary, Aid, Zakia, primary, Prade, Nais, primary, Lagarde, Stephanie, primary, Plassard, Damien, primary, Pierron, Gaelle, primary, Daudigeos, Estelle, primary, Lecluse, Yann, primary, Droin, Nathalie, primary, Bornhauser, Beat C., primary, Cheung, Laurence C., primary, Crispino, John D., primary, Gaudry, Muriel, primary, Bernard, Olivier A., primary, Macintyre, Elizabeth, primary, Barin Bonnigal, Carole, primary, Kotecha, Rishi S., primary, Geoerger, Birgit, primary, Ballerini, Paola, primary, Bourquin, Jean-Pierre, primary, Delabesse, Eric, primary, Mercher, Thomas, primary, and Malinge, Sebastien, primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results