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Your search keyword '"Bourigault, Marie-Laure"' showing total 14 results
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14 results on '"Bourigault, Marie-Laure"'

2. Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization

Author

Segueni, Noria, primary, Tritto, Elaine, additional, Bourigault, Marie-Laure, additional, Rose, Stéphanie, additional, Erard, François, additional, Le Bert, Marc, additional, Jacobs, Muazzam, additional, Di Padova, Franco, additional, Stiehl, Daniel P., additional, Moulin, Pierre, additional, Brees, Dominique, additional, Chibout, Salah-Dine, additional, Ryffel, Bernhard, additional, Kammüller, Michael, additional, and Quesniaux, Valerie F., additional

Published
2016
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4. Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection.

Author

Segueni, Noria, primary, Benmerzoug, Sulayman, additional, Rose, Stéphanie, additional, Gauthier, Amandine, additional, Bourigault, Marie-Laure, additional, Reverchon, Flora, additional, Philippeau, Amandine, additional, Erard, François, additional, Le Bert, Marc, additional, Bouscayrol, Hélène, additional, Wachter, Thierry, additional, Garcia, Irène, additional, Kollias, George, additional, Jacobs, Muazzam, additional, Ryffel, Bernhard, additional, and Quesniaux, Valerie F.J., additional

Published
2016
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5. Tumor necrosis factor neutralization combined with chemotherapy enhances Mycobacterium tuberculosis clearance and reduces lung pathology

Author

Bourigault, Marie-Laure, Vacher, Rachel, Rose, Stéphanie, Olleros, Maria-Luisa, Janssens, Jean-Paul, Quesniaux, Valerie Fj, and Garcia, Irène

Subjects
ddc:616, Original Article, ddc:616.07
Abstract

Tuberculosis (TB) is a major health problem requiring sustained immunity to inhibit Mycobacterium tuberculosis growth and appropriate antimicrobial therapy to prevent dissemination and drug resistance. Cell-mediated immune responses to M. tuberculosis involve the activation of cytokines such as Tumor Necrosis Factor (TNF) which is critical for granuloma formation and host resistance against TB. TNF inhibition, used as therapy for the treatment of inflammatory diseases, disrupts granuloma allowing replication of mycobacteria which may increase the efficacy of TB chemotherapy. To test this hypothesis mice infected with M. tuberculosis were treated with isoniazid (INH) and rifampicin (RMP) in the presence or absence of Enbrel, a soluble TNF receptor antagonist during three phases of M. tuberculosis infection. Inhibition of TNF with Enbrel augmented the efficacy of TB chemotherapy as shown by enhanced mycobacterial clearance from the lung of acute and established infection as well as in chronically infected mice. Furthermore, TNF inhibition significantly reduced lung pathology as compared to TB chemotherapy alone. Therefore, the experimental data suggest that TB chemotherapy may be more effective in the presence of a TNF inhibitor, which may be relevant to eradicate mycobacteria during chronic M. tuberculosis infection or reactivation.

Published
2013

7. Relative contribution of IL‐1α, IL‐1β and TNF to the host response to Mycobacterium tuberculosis and attenuated M. bovis BCG

Author

Bourigault, Marie‐Laure, primary, Segueni, Noria, additional, Rose, Stéphanie, additional, Court, Nathalie, additional, Vacher, Rachel, additional, Vasseur, Virginie, additional, Erard, François, additional, Le Bert, Marc, additional, Garcia, Irene, additional, Iwakura, Yoichiro, additional, Jacobs, Muazzam, additional, Ryffel, Bernhard, additional, and Quesniaux, Valerie F. J., additional

Published
2013
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9. IL-12Rβ2 Is Essential for the Development of Experimental Cerebral Malaria

Author

Fauconnier, Mathilde, primary, Palomo, Jennifer, additional, Bourigault, Marie-Laure, additional, Meme, Sandra, additional, Szeremeta, Frédéric, additional, Beloeil, Jean-Claude, additional, Danneels, Adeline, additional, Charron, Sabine, additional, Rihet, Pascal, additional, Ryffel, Bernhard, additional, and Quesniaux, Valérie F. J., additional

Published
2012
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12. Protein Kinase C-Theta Is Required for Development of Experimental Cerebral Malaria

Author

Fauconnier, Mathilde, primary, Bourigault, Marie-Laure, additional, Meme, Sandra, additional, Szeremeta, Frederic, additional, Palomo, Jennifer, additional, Danneels, Adeline, additional, Charron, Sabine, additional, Fick, Lizette, additional, Jacobs, Muazzam, additional, Beloeil, Jean-Claude, additional, Ryffel, Bernhard, additional, and Quesniaux, Valerie F.J., additional

Published
2011
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14. Synthesis and biological investigation of PIM mimics carrying biotin or a fluorescent label for cellular imaging.

Author

Front S, Bourigault ML, Rose S, Noria S, Quesniaux VF, and Martin OR

Subjects
Animals, Anti-Inflammatory Agents analysis, Aza Compounds analysis, Aza Compounds chemistry, Aza Compounds pharmacology, Biotin chemistry, Biotinylation, Cells, Cultured, Fluorescent Dyes analysis, Macrophages immunology, Mice, Phosphatidylinositols analysis, Rhodamines analysis, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents pharmacology, Cytokines immunology, Lipopolysaccharides immunology, Macrophages drug effects, Phosphatidylinositols chemistry, Phosphatidylinositols pharmacology
Abstract

Phosphatidyl inositol mannosides (PIMs) are constituents of the mycobacterial cell wall; these glycolipids are known to exhibit potent inhibitory activity toward the LPS-induced production of cytokines by macrophages, and therefore have potential as anti-inflammatory agents. Recently, heterocyclic analogues of PIMs in which the inositol is replaced by a piperidine (aza-PIM mimics) or a tetrahydropyran moiety (oxa-PIM mimics) have been prepared by short synthetic sequences and shown to retain the biological activity of the parent PIM structures. In this investigation, the aza-PIM analogue was used as a convenient scaffold to link biotin or a fluorescent label (tetramethyl-rhodamine) by way of an aminocaproyl spacer, with the goal of using these conjugates for intracellular localization and for the study of the mechanism of their antiinflammatory action. The synthesis of these compounds is reported, as well as the evaluation of their activities as inhibitors of LPS-induced cytokine production by macrophages (TNFα, IL12p40); preliminary investigations by FACS and confocal microscopy indicated that PIM-biotin conjugate binds to macrophage membranes with rapid kinetics.

Published
2013
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