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261 results on '"Bourguignon, Thierry"'

2. Right Ventriculoarterial Coupling Surrogates and Long-Term Survival in LVAD Recipients: Results of the ASSIST-ICD Multicentric Registry

Author

BENEYTO, MAXIME, MARTINS, RAPHAËL, GALAND, VINCENT, KINDO, MICHEL, SCHNEIDER, CLÉMENT, SEBESTYEN, ALEXANDRE, BOIGNARD, AUDE, SEBBAG, LAURENT, POZZI, MATTEO, GENET, THIBAUD, BOURGUIGNON, THIERRY, MARTIN, ANNE-CÉLINE, ACHOUH, PAUL, VANHUYSE, FABRICE, BLANG, HUGUES, DAVID, CHARLES HENRI, MICHEL, MAGALI, ANSELME, FRÉDÉRIC, LITZLER, PIERRE-YVES, JUNGLING, MARIE, VINCENTELLI, ANDRÉ, ESCHALIER, ROMAIN, D'OSTREVY, NICOLAS, NATAF, PATRICK, PARA, MARYLOU, GARNIER, FABIEN, RAJINTHAN, PRIYANKA, PORTERIE, JEAN, FAURE, MAXIME, PICARD, FRANÇOIS, GAUDARD, PHILIPPE, ROUVIÈRE, PHILIPPE, BABATASI, GÉRARD, BLANCHART, KATRIEN, GARIBOLDI, VLAD, PORTO, ALIZÉE, FLECHER, ERWAN, and DELMAS, CLEMENT

Published
2024
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8. Comparison of Outcomes and Mortality in Patients Having Left Ventricular Assist Device Implanted Early -vs- Late After Diagnosis of Cardiomyopathy

Author

Chen, Elisabeth, Nesseler, Nicolas, Martins, Raphaël P., Goéminne, Céline, Vincentelli, André, Delmas, Clément, Porterie, Jean, Nubret, Karine, Pernot, Mathieu, Kindo, Michel, Hoang Minh, Tam, Gaudard, Philippe, Rouvière, Philippe, Michel, Magali, Sénage, Thomas, Boignard, Aude, Chavanon, Olivier, Verdonk, Constance, Para, Marylou, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Baudry, Guillaume, Litzler, Pierre-Yves, Anselme, Frédéric, Blanchart, Katrien, Babatasi, Gerard, Garnier, Fabien, Bielefeld, Marie, Radu, Costin, Lellouche, Nicolas, Bourguignon, Thierry, Genet, Thibaud, Eschalier, Romain, D'Ostrevy, Nicolas, Bories, Marie-Cécile, Baudinaud, Pierre, Vanhuyse, Fabrice, Blangy, Hugues, Leclercq, Christophe, Flécher, Erwan, and Galand, Vincent

Published
2021
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10. Sex-related differences among patients undergoing surgical aortic valve replacement—a propensity score matched study

Author

Zierer, Andreas, De Paulis, Ruggero, Bakhtiary, Farhad, Ahmad, Ali El Sayed, Andreas, Martin, Autschbach, Rüdiger, Benedikt, Peter, Binder, Konrad, Bonaros, Nikolaos, Borger, Michael, Bourguignon, Thierry, Canovas, Sergio, Coscioni, Enrico, Dagenais, Francois, Demers, Philippe, Dewald, Oliver, Feyrer, Richard, Geißler, Hans Joachim, Grabenwöger, Martin, Grünenfelder, Jürg, Kueri, Sami, Lam, Ka Yan, Langanay, Thierry, Laufer, Günther, Van Leeuwen, Wouter, Leyh, Rainer, Liebold, Andreas, Mariscalco, Giovanni, Massoudy, Parwis, Mehdiani, Arash, Pessotto, Renzo, Pollari, Francesco, Polvani, Gianluca, Ricci, Alessandro, Roussel, Jean Christian, Salamate, Saad, Siepe, Matthias, Stefano, Pierluigi, Strauch, Justus, Theron, Alexis, Vötsch, Andreas, Weber, Alberto, Wendler, Olaf, Thielmann, Matthias, Eden, Matthias, Botta, Beate, Bramlage, Peter, Meuris, Bart, Zierer, Andreas, De Paulis, Ruggero, Bakhtiary, Farhad, Ahmad, Ali El Sayed, Andreas, Martin, Autschbach, Rüdiger, Benedikt, Peter, Binder, Konrad, Bonaros, Nikolaos, Borger, Michael, Bourguignon, Thierry, Canovas, Sergio, Coscioni, Enrico, Dagenais, Francois, Demers, Philippe, Dewald, Oliver, Feyrer, Richard, Geißler, Hans Joachim, Grabenwöger, Martin, Grünenfelder, Jürg, Kueri, Sami, Lam, Ka Yan, Langanay, Thierry, Laufer, Günther, Van Leeuwen, Wouter, Leyh, Rainer, Liebold, Andreas, Mariscalco, Giovanni, Massoudy, Parwis, Mehdiani, Arash, Pessotto, Renzo, Pollari, Francesco, Polvani, Gianluca, Ricci, Alessandro, Roussel, Jean Christian, Salamate, Saad, Siepe, Matthias, Stefano, Pierluigi, Strauch, Justus, Theron, Alexis, Vötsch, Andreas, Weber, Alberto, Wendler, Olaf, Thielmann, Matthias, Eden, Matthias, Botta, Beate, Bramlage, Peter, and Meuris, Bart

Abstract

OBJECTIVES: We investigated the sex-related difference in characteristics and 2-year outcomes after surgical aortic valve replacement (SAVR) by propensity-score matching (PSM). METHODS:Data from 2 prospective registries, the INSPIRIS RESILIA Durability Registry (INDURE) and IMPACT, were merged, resulting in a total of 933 patients: 735 males and 253 females undergoing first-time SAVR. The PSM was performed to assess the impact of sex on the SAVR outcomes, yielding 433 males and 243 females with comparable baseline characteristics. RESULTS: Females had a lower body mass index (median 27.1 vs 28.0 kg/m2; P ¼ 0.008), fewer bicuspid valves (52% vs 59%; P ¼ 0.036), higher EuroSCORE II (mean 2.3 vs 1.8%; P < 0.001) and Society of Thoracic Surgeons score (mean 1.6 vs 0.9%; P < 0.001), were more often in New York Heart Association functional class III/IV (47% vs 30%; P < 0.001) and angina Canadian Cardiovascular Society III/IV (8.2% vs 4.4%; P < 0.001), but had a lower rate of myocardial infarction (1.9% vs 5.2%; P ¼ 0.028) compared to males. These differences vanished after PSM, except for the EuroSCORE II and Society of Thoracic Surgeons scores, which were still significantly higher in females. Furthermore, females required smaller valves (median diameter 23.0 vs 25.0 mm, P < 0.001). There were no differences in the length of hospital stay (median 8 days) or intensive care unit stay (median 24 vs 25 hours) between the 2 sexes. At 2 years, post-SAVR outcomes were comparable between males and females, even after PSM. CONCLUSIONS: Despite females presenting with a significantly higher surgical risk profile, 2-year outcomes following SAVR were comparable between males and females.

Published
2024

12. Association between pulmonary artery pulsatility and mortality after implantation of left ventricular assist device.

Author

Akamkam, Ali, Galand, Vincent, Jungling, Marie, Delmas, Clément, Dambrin, Camille, Pernot, Mathieu, Kindo, Michel, Gaudard, Philippe, Rouviere, Philippe, Senage, Thomas, Chavanon, Olivier, Para, Marylou, Gariboldi, Vlad, Pozzi, Matteo, Litzler, Pierre‐Yves, Babatasi, Gerard, Bouchot, Olivier, Radu, Costin, Bourguignon, Thierry, and D'Ostrevy, Nicolas

Subjects
PULMONARY artery, RECEIVER operating characteristic curves, VENOUS pressure, SURVIVAL rate, HEART transplantation, HEART assist devices
Abstract

Aims: Right ventricular failure after left ventricular assist device (LVAD) implantation is a major concern that remains challenging to predict. We sought to investigate the relationship between preoperative pulmonary artery pulsatility index (PAPi) and mortality after LVAD implantation. Methods and results: A retrospective analysis of the ASSIST‐ICD multicentre registry allowed the assessment of PAPi before LVAD according to the formula [(systolic pulmonary artery pressure − diastolic pulmonary artery pressure)/central venous pressure]. The primary endpoint was survival at 3 months, according to the threshold value of PAPi determined by the receiver operating characteristic (ROC) curve. A multivariate analysis including demographic, echographic, haemodynamic, and biological variables was performed to identify predictive factors for 2 year mortality. One hundred seventeen patients were included from 2007 to 2021. The mean age was 58.45 years (±13.16), with 15.4% of women (sex ratio 5.5). A total of 53.4% were implanted as bridge to transplant and 43.1% as destination therapy. Post‐operative right ventricular failure was observed in 57 patients (48.7%), with no significant difference between survivors and non‐survivors at 1 month (odds ratio 1.59, P = 0.30). The median PAPi for the whole study population was 2.83 [interquartile range 1.63–4.69]. The threshold value of PAPi determined by the ROC curve was 2.84. Patients with PAPi ≥ 2.84 had a higher survival rate at 3 months [PAPi < 2.84: 58.1% [46.3–72.8%] vs. PAPi ≥ 2.84: 89.1% [81.1–97.7%], hazard ratio (HR) 0.08 [0.02–0.28], P < 0.01], with no significant difference after 3 months (HR 0.67 [0.17–2.67], P = 0.57). Other predictors of 2 year mortality were systemic hypertension (HR 4.22 [1.49–11.97], P < 0.01) and diabetes mellitus (HR 4.90 [1.83–13.14], P < 0.01). LVAD implantation as bridge to transplant (HR 0.18 [0.04–0.74], P = 0.02) and heart transplantation (HR 0.02 [0.00–0.18], P < 0.01) were associated with a higher survival rate at 2 years. Conclusions: Preoperative PAPi < 2.84 was associated with a higher risk of early mortality after LVAD implantation without impacting 2 year outcomes among survivors. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Septuagenarian population has similar survival and outcomes to younger patients after left ventricular assist device implantation

Author

Galand, Vincent, Flécher, Erwan, Chabanne, Céline, Lelong, Bernard, Goéminne, Céline, Vincentelli, André, Delmas, Clément, Dambrin, Camille, Nubret, Karine, Pernot, Mathieu, Kindo, Michel, Hoang Minh, Tam, Gaudard, Philippe, Frapier, Jean Marc, Michel, Magali, Sénage, Thomas, Boignard, Aude, Chavanon, Olivier, Verdonk, Constance, Para, Marylou, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Obadia, Jean-François, Litlzer, Pierre Yves, Anselme, Frédéric, Babatasi, Gerard, Plane, Anne Flore, Garnier, Fabien, Bielefeld, Marie, Hamon, David, Radu, Costin, Bourguignon, Thierry, Genet, Thibaud, Eschalier, Romain, D’Ostrevy, Nicolas, Bories, Marie-Cécile, Marijon, Eloi, Vanhuyse, Fabrice, Blangy, Hugues, Leclercq, Christophe, and Martins, Raphaël P.

Published
2020
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14. Relation of Body Mass Index to Outcomes in Patients With Heart Failure Implanted With Left Ventricular Assist Devices

Author

Galand, Vincent, Flécher, Erwan, Lelong, Bernard, Chabanne, Céline, Charton, Marion, Goéminne, Céline, Vincentelli, André, Porterie, Jean, Delmas, Clément, Nubret, Karine, Pernot, Mathieu, Kindo, Michel, Hoang Minh, Tam, Gaudard, Philippe, Rouvière, Philippe, Sénage, Thomas, Michel, Magali, Boignard, Aude, Chavanon, Olivier, Verdonk, Constance, Para, Marylou, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Obadia, Jean-François, Litzler, Pierre-Yves, Anselme, Frédéric, Blanchart, Katrien, Babatasi, Gerard, Garnier, Fabien, Bielefeld, Marie, Radu, Costin, Hamon, David, Bourguignon, Thierry, Genet, Thibaud, Eschalier, Romain, D'Ostrevy, Nicolas, Bories, Marie-Cécile, Varlet, Emilie, Vanhuyse, Fabrice, Sadoul, Nicolas, Leclercq, Christophe, and Martins, Raphaël P.

Published
2020
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17. Outcomes of Left Ventricular Assist Device Implantation in Patients With Uncommon Etiology Cardiomyopathy

Author

Galand, Vincent, Flécher, Erwan, Chabanne, Céline, Lelong, Bernard, Goéminne, Céline, Vincentelli, André, Delmas, Clément, Dambrin, Camille, Picard, François, Sacher, Frédéric, Kindo, Michel, Minh, Tam Hoang, Gaudard, Philippe, Rouvière, Philippe, Sénage, Thomas, Michel, Magali, Boignard, Aude, Chavanon, Olivier, Verdonk, Constance, Ghodhbane, Walid, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Obadia, Jean-François, Litzler, Pierre-Yvesl, Anselme, Frédéric, Babatasi, Gerard, Blanchart, Katrien, Garnier, Fabien, Bielefeld, Marie, Hamon, David, Lellouche, Nicolas, Bourguignon, Thierry, Genet, Thibaud, Eschalier, Romain, D'Ostrevy, Nicolas, Varlet, Emilie, Jouan, Jérôme, Vanhuyse, Fabrice, Blangy, Hugues, Leclercq, Christophe, and Martins, Raphaël P.

Published
2020
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18. Incidence, predictors, and clinical impact of electrical storm in patients with left ventricular assist devices: New insights from the ASSIST-ICD study

Author

Martins, Raphaël P., Leclercq, Christophe, Bourenane, Hamed, Auffret, Vincent, Boulé, Stéphane, Loobuyck, Valentin, Dambrin, Camille, Mondoly, Pierre, Sacher, Frédéric, Bordachar, Pierre, Kindo, Michel, Cardi, Thomas, Gaudard, Philippe, Rouvière, Philippe, Michel, Magali, Gourraud, Jean-Baptiste, Defaye, Pascal, Chavanon, Olivier, Kerneis, Caroline, Ghodhbane, Walid, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Grinberg, Daniel, Litzler, Pierre-Yves, Anselme, Frédéric, Babatasi, Gerard, Belin, Annette, Garnier, Fabien, Bielefeld, Marie, Hamon, David, Lellouche, Nicolas, Pierre, Bertrand, Bourguignon, Thierry, Eschallier, Romain, D’Ostrevy, Nicolas, Bories, Marie-Cécile, Jouan, Jérôme, Vanhuyse, Fabrice, Sadoul, Nicolas, Flécher, Erwan, and Galand, Vincent

Published
2019
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20. Early Ventricular Arrhythmias After LVAD Implantation Is the Strongest Predictor of 30-Day Post-Operative Mortality

Author

Galand, Vincent, Flécher, Erwan, Auffret, Vincent, Pichard, Camille, Boulé, Stéphane, Vincentelli, André, Rollin, Anne, Mondoly, Pierre, Barandon, Laurent, Pernot, Mathieu, Kindo, Michel, Cardi, Thomas, Gaudard, Philippe, Rouvière, Philippe, Sénage, Thomas, Jacob, Nicolas, Defaye, Pascal, Chavanon, Olivier, Verdonk, Constance, Ghodbane, Walid, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Obadia, Jean-François, Savouré, Arnaud, Anselme, Frédéric, Babatasi, Gerard, Belin, Annette, Garnier, Fabien, Bielefeld, Marie, Hamon, David, Lellouche, Nicolas, Pierre, Bertrand, Bourguignon, Thierry, Eschalier, Romain, D’Ostrevy, Nicolas, Bories, Marie-Cécile, Marijon, Eloi, Vanhuyse, Fabrice, Blangy, Hugues, Verhoye, Jean-Philippe, Leclercq, Christophe, and Martins, Raphaël P.

Published
2019
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21. Aortic Valve Surgery in Nonelderly Patients: Insights Gained From AVIATOR

Author

Dinges, Christian, Steindl, Johannes, Ziller, Rosina, Benkacem, Taoufik, Coulon, Corinne, Kaddouri, Fadoua, de Meester, Christophe, Pasquet, Agnès, Nijs, Jan, Van Mossevelde, Veerle, Loeys, Bart, Meuris, Bart, Schepmans, Evi, Van den Bossche, Klaartje, Verbrugghe, Peter, Goossens, Wenke, Gutermann, Herbert, Pettinari, Matteo, Lenoir, Marien, Noly, Pierre-Emmanuel, Tousch, Michael, Shah, Pallav, Boodhwani, Munir, Rudez, Igor, Baric, Davor, Unic, Daniel, Varvodic, Josip, Gjorgijevska, Savica, Vojacek, Jan, Zacek, Pavel, Karalko, Mikita, Hlubocky, Jaroslav, Novotny, Robert, Slautin, Andrey, Soliman, Said, Arnaud-Crozat, Eric, Boignard, Aude, Fayad, Georges, Bouchot, Olivier, Albat, Bernard, Leguerrier, Alain, Doguet, Fabien, Fuzellier, Jean-François, Glock, Yves, Fernandez, Guy, Chatel, Didier, Zeitoun, David Messika, Jouan, Jérôme, Di Centa, Isabelle, Obadia, Jean-François, Leprince, Pascal, Houel, Rémi, Bergoend, Eric, Lopez, Stéphane, Berrebi, Alain, Tubach, Florence, Monin, Jean-Luc, Pousset, Sarah, Mankoubi, Leila, Noghin, Milean, Diakov, Christelle, Czytrom, Daniel, Borger, Michael, Aicher, Diana, Rauch, Svenja, Theisohn, Frank, Ferrero, Paolo, Stoica, Serban, Matuszewski, Maciej, Yiu, Patrick, Bashir, Mohamad, Ceresa, Fabrizio, Patane, Francesco, De Paulis, Ruggero, Chirichilli, Ilaria, Masat, Mauro, Antona, Carlo, Contino, Monica, Mangini, Andrea, Romagnoni, Claudia, Grigioni, Francesco, Rosa, Rubina, Okita, Yutaka, Miyairi, Takeshi, Kunihara, Takashi, Koolbergen, Dave, Bekkers, Jos, Klautz, Robert, Van Brakel, Thomas, Arabkhani, Bardia, Mecozzi, Gianclaudio, Accord, Ryan, Jasinski, Marek, Aminov, Vladislav, Svetkin, Mihail, Kolesar, Adrian, Sabol, František, Toporcer, Tomas, Bibiloni, Ignacio, Rábago, Gregorio, Alvarez-Asiain, Virginia, Melero, Amaia, Sadaba, Rafael, Aramendi, José, Crespo, Alejandro, Porras, Carlos, Masip, Arturo Evangelista, Milewski, Rita, Moeller, Patrick, Wenger, Isaac, Leon, Christine, Marnette, Jean Marc, Doisy, Vincent, Wautot, Fabrice, Bourguignon, Thierry, Cameron, Duke, Chen, Edward, Lansac, Emmanuel, Youssefi, Pouya, de Heer, Frederiek, Bavaria, Joseph, De Kerchove, Laurent, El-Hamamsy, Ismail, Elkhoury, Gebrine, Enriquez-Sarano, Maurice, Jondeau, Laurent de Guillaume, Kluin, Jolanda, Pibarot, Philippe, Schäfers, Hans-Joachim, Vanoverschelde, Jean-Louis, and Takkenberg, Johanna J.M.

Published
2019
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22. Predictors and Clinical Impact of Late Ventricular Arrhythmias in Patients With Continuous-Flow Left Ventricular Assist Devices

Author

Galand, Vincent, Flécher, Erwan, Auffret, Vincent, Boulé, Stéphane, Vincentelli, André, Dambrin, Camille, Mondoly, Pierre, Sacher, Frédéric, Nubret, Karine, Kindo, Michel, Cardi, Thomas, Gaudard, Philippe, Rouvière, Philippe, Michel, Magali, Gourraud, Jean-Baptiste, Defaye, Pascal, Chavanon, Olivier, Verdonk, Constance, Ghodbane, Walid, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Obadia, Jean-François, Litzler, Pierre-Yves, Anselme, Frédéric, Babatasi, Gerard, Belin, Annette, Garnier, Fabien, Bielefeld, Marie, Hamon, David, Radu, Costin, Pierre, Bertrand, Bourguignon, Thierry, Eschalier, Romain, D’Ostrevy, Nicolas, Bories, Marie-Cécile, Marijon, Eloi, Vanhuyse, Fabrice, Blangy, Hugues, Verhoye, Jean-Philippe, Leclercq, Christophe, and Martins, Raphaël P.

Published
2018
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24. Contemporary management of severe symptomatic bicuspid aortic valve stenosis: the BiTri Registry

Author

De Biase, Chiara, Siddiqui, Saif, Brochado, Bruno, Ziviello, Francesca, van Mieghem, Nicolas M., De Backer, Ole, Sondergaard, Lars, Silveira, João, Saint-Etienne, Christophe, Bourguignon, Thierry, Lange, Rudiger, Jovanovic, Marija, Berthoumieu, Pierre, Bleiziffer, Sabine, Tuccillo, Andrea, Lemee, Caroline, Chapdelaine, Kevin, Dumonteil, Nicolas, and Tchetche, Didier

Published
2020
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25. Suicide Attempts Among LVAD Recipients: Real-Life Data From the ASSIST-ICD Study

Author

Charton, Marion, Flécher, Erwan, Leclercq, Christophe, Delmas, Clément, Dambrin, Camille, Goeminne, Céline, Vincentelli, André, Michel, Magali, Lehelias, Laurence, Verdonk, Constance, Para, Marylou, Pozzi, Matteo, Obadia, Jean-François, Boignard, Aude, Chavanon, Olivier, Barandon, Laurent, Nubret, Karine, Kindo, Michel, Minh, Tam Hoang, Gaudard, Philippe, Pelcé, Edeline, Gariboldi, Vlad, Litzler, Pierre-Yves, Anselme, Frédéric, Babatasi, Gerard, Belin, Annette, Garnier, Fabien, Bielefeld, Marie, Hamon, David, Lellouche, Nicolas, Bourguignon, Thierry, Genet, Thibaud, Eschalier, Romain, D’Ostrevy, Nicolas, Bories, Marie-Cécile, Jouan, Jérôme, Vanhuyse, Fabrice, Blangy, Hugues, Doucerain, Julie, Martins, Raphael P., and Galand, Vincent

Published
2020
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26. Durability of bioprosthetic aortic valve replacement in patients under the age of 60 years – 1-year follow-up from the prospective INDURE registry

Author

Meuris, Bart, primary, Roussel, Jean-Christian, additional, Borger, Michael A, additional, Siepe, Matthias, additional, Stefano, Pierluigi, additional, Laufer, Günther, additional, Langanay, Thierry, additional, Theron, Alexis, additional, Grabenwöger, Martin, additional, Binder, Konrad, additional, Demers, Philippe, additional, Pessotto, Renzo, additional, van Leeuwen, Wouter, additional, Bourguignon, Thierry, additional, Canovas, Sergio, additional, Mariscalco, Giovanni, additional, Coscioni, Enrico, additional, Dagenais, Francois, additional, Wendler, Olaf, additional, Polvani, Gianluca, additional, Eden, Matthias, additional, Botta, Beate, additional, Bramlage, Peter, additional, and De Paulis, Ruggero, additional

Published
2023
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29. Durability of bioprosthetic aortic valves in patients under the age of 60 years – rationale and design of the international INDURE registry

Author

Meuris, Bart, Borger, Michael A., Bourguignon, Thierry, Siepe, Matthias, Grabenwöger, Martin, Laufer, Günther, Binder, Konrad, Polvani, Gianluca, Stefano, Pierluigi, Coscioni, Enrico, van Leeuwen, Wouter, Demers, Philippe, Dagenais, Francois, Canovas, Sergio, Theron, Alexis, Langanay, Thierry, Roussel, Jean-Christian, Wendler, Olaf, Mariscalco, Giovanni, Pessotto, Renzo, Botta, Beate, Bramlage, Peter, and de Paulis, Ruggero

Published
2020
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35. Standardized Definition of Structural Valve Degeneration for Surgical and Transcatheter Bioprosthetic Aortic Valves

Author

Dvir, Danny, Bourguignon, Thierry, Otto, Catherine M., Hahn, Rebecca T., Rosenhek, Raphael, Webb, John G., Treede, Hendrik, Sarano, Maurice E., Feldman, Ted, Wijeysundera, Harindra C., Topilsky, Yan, Aupart, Michel, Reardon, Michael J., Mackensen, G. Burkhard, Szeto, Wilson Y., Kornowski, Ran, Gammie, James S., Yoganathan, Ajit P., Arbel, Yaron, Borger, Michael A., Simonato, Matheus, Reisman, Mark, Makkar, Raj R., Abizaid, Alexandre, McCabe, James M., Dahle, Gry, Aldea, Gabriel S., Leipsic, Jonathon, Pibarot, Philippe, Moat, Neil E., Mack, Michael J., Kappetein, A. Pieter, and Leon, Martin B.

Published
2018
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36. Predictors of Device-Related Thrombus Following Percutaneous Left Atrial Appendage Occlusion

Author

Fauchier, Grégoire, Bisson, Arnaud, Bodin, Alexandre, Herbert, Julien, Semaan, Carl, Angoulvant, Denis, Ducluzeau, Pierre Henri, Lip, Gregory, Fauchier, Laurent, Deharo, Pierre, Cuisset, Thomas, Lacour, Thibaud, Etienne, Christophe Saint, Jaussaud, Nicolas, Morera, Pierre, Spychaj, Jean-Charles, Porto, Alizée, Collart, Frederic, Theron, Alexis, Bernard, Anne, Bourguignon, Thierry, Simard, Trevor, Jung, Richard, Lehenbauer, Kyle, Piayda, Kerstin, Pracoń, Radoslaw, Jackson, Gregory, Flores-Umanzor, Eduardo, Faroux, Laurent, Korsholm, Kasper, Chun, Julian K.R., Chen, Shaojie, Maarse, Moniek, Montrella, Kristi, Chaker, Zakeih, Spoon, Jocelyn, Pastormerlo, Luigi, Meincke, Felix, Sawant, Abhishek, Moldovan, Carmen, Qintar, Mohammed, Aktas, Mehmet, Branca, Luca, Radinovic, Andrea, Ram, Pradhum, El-Zein, Rayan, Flautt, Thomas, Ding, Wern Yew, Sayegh, Bassel, Benito-González, Tomás, Lee, Oh-Hyun, Badejoko, Solomon, Paitazoglou, Christina, Karim, Nabeela, Zaghloul, Ahmed, Agrawal, Himanshu, Kaplan, Rachel, Alli, Oluseun, Ahmed, Aamir, Suradi, Hussam, Knight, Bradley, Alla, Venkata, Panaich, Sidakpal, Wong, Tom, Bergmann, Martin, Chothia, Rashaad, Kim, Jung-Sun, Pérez de Prado, Armando, Bazaz, Raveen, Gupta, Dhiraj, Valderrabano, Miguel, Sanchez, Carlos, El Chami, Mikhael, Mazzone, Patrizio, Adamo, Marianna, Ling, Fred, Wang, Dee Dee, O’neill, William, Wojakowski, Wojtek, Pershad, Ashish, Berti, Sergio, Spoon, Daniel, Kawsara, Akram, Jabbour, George, Boersma, Lucas V.A., Schmidt, Boris, Nielsen-Kudsk, Jens Erik, Rodés-Cabau, Josep, Freixa, Xavier, Ellis, Christopher, Demkow, Marcin, Sievert, Horst, Main, Michael, Hibbert, Benjamin, Holmes, David, Alkhouli, Mohamad, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Trousseau [Tours], Éducation Éthique Santé EA 7505 (EES), Université de Tours (UT), EA4245 - Transplantation, Immunologie, Inflammation [Tours] (T2i), University of Liverpool, Aalborg University [Denmark] (AAU), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital de la Timone [CHU - APHM] (TIMONE), Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Marseille, Département de Cardiologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University of Ottawa [Ottawa], Université Laval [Québec] (ULaval), National Institute for Research and Development in Microtechnologies (IMT-Bucharest), Graduate School, Cardiology, and ACS - Heart failure & arrhythmias

Subjects
Male, Cardiac Catheterization, Time Factors, Percutaneous, left atrial appendage occlusion, Septal Occluder Device, medicine.medical_treatment, Transesophageal, [SHS]Humanities and Social Sciences, Pulmonary vein, Postoperative Complications, Risk Factors, Interquartile range, Atrial Fibrillation, Registries, Embolization, ComputingMilieux_MISCELLANEOUS, Watchman, Incidence, Atrial fibrillation, Europe, Survival Rate, Treatment Outcome, Echocardiography, Cardiology, Female, Watchman FLX, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Heart Diseases, ACP, Amplatzer cardiac plug, Amulet, DRT, LAAO, device-related thrombus, Aged, Atrial Appendage, Echocardiography, Transesophageal, Follow-Up Studies, Humans, Thrombosis, Left atrial appendage occlusion, Internal medicine, medicine, Risk factor, Thrombus, business.industry, medicine.disease, business
Abstract

Background: Device-related thrombus (DRT) has been considered an Achilles’ heel of left atrial appendage occlusion (LAAO). However, data on DRT prediction remain limited. Objectives: This study constructed a DRT registry via a multicenter collaboration aimed to assess outcomes and predictors of DRT. Methods: Thirty-seven international centers contributed LAAO cases with and without DRT (device-matched and temporally related to the DRT cases). This study described the management patterns and mid-term outcomes of DRT and assessed patient and procedural predictors of DRT. Results: A total of 711 patients (237 with and 474 without DRT) were included. Follow-up duration was similar in the DRT and no-DRT groups, median 1.8 years (interquartile range: 0.9-3.0 years) versus 1.6 years (interquartile range: 1.0-2.9 years), respectively (P = 0.76). DRTs were detected between days 0 to 45, 45 to 180, 180 to 365, and >365 in 24.9%, 38.8%, 16.0%, and 20.3% of patients. DRT presence was associated with a higher risk of the composite endpoint of death, ischemic stroke, or systemic embolization (HR: 2.37; 95% CI, 1.58-3.56; P < 0.001) driven by ischemic stroke (HR: 3.49; 95% CI: 1.35-9.00; P = 0.01). At last known follow-up, 25.3% of patients had DRT. Discharge medications after LAAO did not have an impact on DRT. Multivariable analysis identified 5 DRT risk factors: hypercoagulability disorder (odds ratio [OR]: 17.50; 95% CI: 3.39-90.45), pericardial effusion (OR: 13.45; 95% CI: 1.46-123.52), renal insufficiency (OR: 4.02; 95% CI: 1.22-13.25), implantation depth >10 mm from the pulmonary vein limbus (OR: 2.41; 95% CI: 1.57-3.69), and non-paroxysmal atrial fibrillation (OR: 1.90; 95% CI: 1.22-2.97). Following conversion to risk factor points, patients with ≥2 risk points for DRT had a 2.1-fold increased risk of DRT compared with those without any risk factors. Conclusions: DRT after LAAO is associated with ischemic events. Patient- and procedure-specific factors are associated with the risk of DRT and may aid in risk stratification of patients referred for LAAO.

Published
2021
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38. A Simplified Delivery Frozen Elephant Trunk Technique to Reduce Circulatory Arrest Time in Hybrid Aortic Arch Surgery: Early Results in a Cohort of 158 Patients

Author

Guimbretiere, Guillaume, additional, Bonnet, Nicolas, additional, Gonthier, Sebastien, additional, Crepon, Clementine, additional, Fouquet, Olivier, additional, Kermen, Stephane, additional, Bourguignon, Thierry, additional, Tomasi, Jacques, additional, Braunberger, Eric, additional, and Senage, Thomas, additional

Published
2022
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42. Mortality and cardiac resynchronization therapy with or without defibrillation in primary prevention

Author

Deharo, Pierre, Bisson, Arnaud, Herbert, Julien, Lacour, Thibaud, Saint Etienne, Christophe, Jaussaud, Nicolas, Theron, Alexis, Collart, Frederic, Bourguignon, Thierry, Cuisset, Thomas, Fauchier, Laurent, Gras, Matthieu, Bodin, Alexandre, Babuty, Dominique, Pierre, Bertrand, Clementy, Nicolas, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), Université de Tours (UT), CHU Marseille, Hôpital de la Timone [CHU - APHM] (TIMONE), Département de Cardiologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and EA4245 - Transplantation, Immunologie, Inflammation [Tours] (T2i)

Subjects
medicine.medical_specialty, medicine.medical_treatment, Myocardial Ischemia, Cardiomyopathy, Cardiac resynchronization therapy, [SHS]Humanities and Social Sciences, Cardiac Resynchronization Therapy, Risk Factors, Physiology (medical), Internal medicine, medicine, Humans, Cardiac Resynchronization Therapy Devices, Aged, Heart Failure, business.industry, Mortality rate, Hazard ratio, Implantable cardioverter-defibrillator, medicine.disease, Confidence interval, Defibrillators, Implantable, Primary Prevention, Death, Sudden, Cardiac, Treatment Outcome, Heart failure, Population study, Cardiology and Cardiovascular Medicine, business
Abstract

Aims Cardiac resynchronization therapy with (CRTD) or without (CRTP) defibrillator is recommended in selected patient with systolic chronic heart failure and wide QRS. There is no guideline firmly indicating choice between CRTP and CRTD in primary prevention, particularly in older patients. Methods and results Based on the French administrative hospital-discharge database, information was collected from 2010 to 2017 for all patients implanted with CRTP or CRTD in primary prevention. Outcome analyses were undertaken in the total study population and in propensity-matched samples. During follow-up (913 days, SD 841, median 701, IQR 151–1493), 45 697 patients were analysed (CRTP 19 266 and CRTD 26 431). Incidence rate (%patient/year) of all-cause mortality was higher in CRTP patients (11.6%) than in CRTD patients (6.8%) [hazard ratio (HR) 1.70, 95% confidence interval (CI) 1.63–1.76, P Conclusion In this real-life study, CRTD was associated with a significantly lower all-cause mortality than CRTP in patients with ICM and in patients with NICM under 75 years old. Patients over 75 years old with NICM did not have lower mortality with primary prevention CRTD implantation.

Published
2020
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43. Outcome of Temporary Circulatory Support As a Bridge-to-Left Ventricular Assist Device Strategy in Cardiogenic Shock Patients

Author

Bidaut, Auriane, primary, Flécher, Erwan, additional, Nesseler, Nicolas, additional, Bounader, Karl, additional, Vincentelli, André, additional, Moussa, Mouhammed, additional, Delmas, Clément, additional, Porterie, Jean, additional, Nubret, Karine, additional, Pernot, Mathieu, additional, Kindo, Michel, additional, Schneider, Clément, additional, Gaudard, Philippe, additional, Rouvière, Philippe, additional, Michel, Magali, additional, Sénage, Thomas, additional, Boignard, Aude, additional, Chavanon, Olivier, additional, Verdonk, Constance, additional, Para, Marylou, additional, Maille, Baptiste, additional, Gariboldi, Vlad, additional, Pozzi, Matteo, additional, Hugon-Vallet, Elisabeth, additional, Litzler, Pierre-Yves, additional, Anselme, Frédéric, additional, Blanchart, Katrien, additional, Babatasi, Gerard, additional, Bielefeld, Marie, additional, Grosjean, Sandrine, additional, Radu, Costin, additional, Hamon, David, additional, Bourguignon, Thierry, additional, Genet, Thibaud, additional, Eschalier, Romain, additional, D’Ostrevy, Nicolas, additional, Nougue, Hélène, additional, Martin, Anne Cécile, additional, Vanhuyse, Fabrice, additional, Blangy, Hugues, additional, Leclercq, Christophe, additional, Martins, Raphael P., additional, and Galand, Vincent, additional

Published
2022
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47. Contemporary management of severe symptomatic bicuspid aortic valve stenosis:the BiTri Registry

Author

De Biase, Chiara, Siddiqui, Saif, Brochado, Bruno, Ziviello, Francesca, van Mieghem, Nicolas M., De Backer, Ole, Sondergaard, Lars, Silveira, João, Saint-Etienne, Christophe, Bourguignon, Thierry, Lange, Rudiger, Jovanovic, Marija, Berthoumieu, Pierre, Bleiziffer, Sabine, Tuccillo, Andrea, Lemee, Caroline, Chapdelaine, Kevin, Dumonteil, Nicolas, Tchetche, Didier, De Biase, Chiara, Siddiqui, Saif, Brochado, Bruno, Ziviello, Francesca, van Mieghem, Nicolas M., De Backer, Ole, Sondergaard, Lars, Silveira, João, Saint-Etienne, Christophe, Bourguignon, Thierry, Lange, Rudiger, Jovanovic, Marija, Berthoumieu, Pierre, Bleiziffer, Sabine, Tuccillo, Andrea, Lemee, Caroline, Chapdelaine, Kevin, Dumonteil, Nicolas, and Tchetche, Didier

Abstract

AIMS: A greater number of patients with bicuspid aortic valves (BAV) may be identified and treated as indications for transcatheter aortic valve implantation (TAVI) are expected to expand to younger patients. We evaluated the contemporary frequency and management of symptomatic patients with stenotic BAV in a multicenter European registry. METHODS: Between November 2017 and February 2018, all consecutive patients admitted for symptomatic aortic stenosis across six high-volume European hospitals were prospectively enrolled in the BiTri registry. RESULTS: Of the 832 patients, 17% (n = 138) had a BAV. The most frequent BAV phenotypes were type 1 (left--right coronary cusps fusion 64%) and type 1 (right-noncoronary cusps fusion 17%). Type 0 and type 2 accounted for 12 and 2%, respectively. When compared with tricuspid patients (n = 694), BAV patients were younger, with lower surgical risk. The transthoracic echocardiography (TTE) identified BAV in 64% of patients. Multisliced computed tomography (MSCT) additionally completed the diagnosis in 20% of patients. Surgical inspection finally identified the remaining undiagnosed 16% of BAV. A combination of TTE and MSCT was the most common diagnosis method for BAV. Surgical aortic valve replacement (SAVR) was the predominant therapeutic option for BAV (70%) whilst TAVI was performed in 26%. CONCLUSION: BAV is frequently observed in symptomatic patients with aortic stenosis. These patients are younger, have a lower risk profile and are predominantly treated with SAVR as compared with tricuspid patients. However, TAVI is performed in almost one-third of BAV patients in contemporary European practice. TTE combined with MSCT identified 84% of BAV.

Published
2021

48. Thromboembolism, mortality, and bleeding in 2,435,541 atrial fibrillation patients with and without cancer: A nationwide cohort study

Author

Lantelme, Pierre, Bisson, Arnaud, Lacour, Thibaud, Herbert, Julien, Ivanes, Fabrice, Bourguignon, Thierry, Angoulvant, Denis, Harbaoui, Brahim, Bonnet, Marc, Babuty, Dominique, Saint Etienne, Christophe, Deharo, Pierre, Fauchier, Laurent, Pastori, Daniele, Marang, Amélie, Menichelli, Danilo, Lip, Gregory, Imagerie Ultrasonore, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), Université de Tours (UT), EA4245 - Transplantation, Immunologie, Inflammation [Tours] (T2i), Institut de Socio-économie des Entreprises et des ORganisations (ISEOR), Institut de socio-économie des entreprises et des organisations, Laboratoire de Recherche Magellan, Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut d'Administration des Entreprises (IAE) - Lyon, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Liverpool, and Aalborg University [Denmark] (AAU)

Subjects
Adult, Cancer Research, medicine.medical_specialty, Hemorrhage, Gastroenterology, Risk Assessment, [SHS]Humanities and Social Sciences, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Uterine cancer, Risk Factors, Internal medicine, Neoplasms, Thromboembolism, Atrial Fibrillation, medicine, cancer, Humans, 030212 general & internal medicine, atrial fibrillation, bleeding, mortality, stroke, thromboembolism, Lung cancer, Stroke, ComputingMilieux_MISCELLANEOUS, Aged, Retrospective Studies, business.industry, Cancer, Retrospective cohort study, medicine.disease, Oncology, 030220 oncology & carcinogenesis, Liver function, Liver cancer, business
Abstract

Background The number of patients with atrial fibrillation (AF) and cancer is rapidly increasing in clinical practice. The impact of cancer on clinical outcomes in this patient population is unclear, as is the performance of the HAS-BLED (Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drugs/Alcohol) and CHA2 DS2 -VASc (Congestive Heart Failure, Hypertension, Age ≥ 75 years, Diabetes Mellitus, Stroke or Transient Ischemic Attack, Vascular Disease, Age 65 to 74 Years, Sex Category) scores. Methods This was an observational, retrospective cohort study including 2,435,541 adults hospitalized with AF. The authors investigated the incidence rates (IRs) of all-cause and cardiovascular mortality, ischemic stroke, major bleeding, and intracranial hemorrhage (ICH) according to the presence of cancer and cancer types. Results Overall, 399,344 (16.4%) had cancer, with the most common cancers being metastatic, prostatic, colorectal, lung, breast, and bladder. During a mean follow-up of 2.0 years, cancer increased all-cause mortality (hazard ratio [HR], 2.00; 95% confidence interval [CI], 1.99-2.01). The IR of ischemic stroke was higher with pancreatic cancer (2.8%/y), uterine cancer (2.6%/y), and breast cancer (2.6%/y), whereas it was lower with liver/lung cancer (1.9%/y) and leukemia/myeloma (2.0%/y), in comparison with noncancer patients (2.4%/y). Cancer increased the risk of major bleeding (HR, 1.27; 95% CI, 1.26-1.28) and ICH (HR, 1.07; 95% CI, 1.05-1.10). Leukemia, liver cancer, myeloma, and metastatic cancers showed the highest IRs for major bleeding/ICH. Major bleeding and ICH rates progressively increased with the HAS-BLED score, which showed generally good predictivity with C indexes > 0.70 for all cancer types. The CHA2 DS2 -VASc score's predictivity was slightly lower in AF patients with cancer. Conclusions Cancer increased all-cause mortality, major bleeding, and ICH risk in AF patients. The association between cancer and ischemic stroke differed among cancer types, and in some types, the risk of bleeding seemed to exceed the thromboembolic risk.

Published
2020
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