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18 results on '"Bourdon, Aurélien"'

4. The KAT6B::KANSL1 Fusion Defines a New Uterine Sarcoma With Hybrid Endometrial Stromal Tumor and Smooth Muscle Tumor Features

Author

Trecourt, Alexis, Azmani, Rihab, Hostein, Isabelle, Blanchard, Larry, Le Loarer, François, Bourdon, Aurelien, Alame, Melissa, Nadaud, Béatrice, Mayer, Laetitia, Rebier, Flora, Larmonier, Claire, Moura, Madalena Souto, Soubeyran, Isabelle, Hartog, Cécile, Ray-Coquard, Isabelle, Treilleux, Isabelle, Devouassoux-Shisheboran, Mojgan, and Croce, Sabrina

Published
2023
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5. Feasibility of high-throughput sequencing in clinical routine cancer care: lessons from the cancer pilot project of the France Genomic Medicine 2025 plan

Author

Auzanneau, Céline, Bacq, Delphine, Bellera, Carine, Blons, Hélène, Boland, Anne, Boucheix, Marlène, Bourdon, Aurélien, Chollet, Emmanuelle, Chomienne, Christine, Deleuze, Jean-François, Delmas, Christelle, Dinart, Derek, Espérou, Hélène, Geillon, Flore, Geneste, Damien, Italiano, Antoine, Jean, Delphine, Khalifa, Emmanuel, Laizet, Yec'han, Laurent-Puig, Pierre, Lethimonnier, Franck, Lévy-Marchal, Claire, Lucchesi, Carlo, Malle, Carine, Mancini, Pierre, Mathoulin-Pélissier, Simone, Meyer, Vincent, Marie-Ange, Palomares, Perkins, Géraldine, Sellan-Albert, Sabrina, Soubeyran, Isabelle, and Wallet, Cédric

Published
2020
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7. Antitumor Effects of PRMT5 Inhibition in Sarcomas

Author

Verbeke, Stéphanie, primary, Bourdon, Aurélien, additional, Guegan, Jean-Philippe, additional, Leroy, Laura, additional, Chaire, Vanessa, additional, Richard, Elodie, additional, Bessede, Alban, additional, and Italiano, Antoine, additional

Published
2023
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8. THE GLAM AIRBORNE CAMPAIGN ACROSS THE MEDITERRANEAN BASIN

Author

Ricaud, Philippe, Zbinden, Régina, Catoire, Valéry, Brocchi, Vanessa, Dulac, François, Hamonou, Eric, Canonici, Jean-Christophe, El Amraoui, Laaziz, Massart, Sébastien, Piguet, Bruno, Dayan, Uri, Nabat, Pierre, Sciare, Jean, Ramonet, Michel, Delmotte, Marc, di Sarra, Alcide, Sferlazzo, Damiano, di Iorio, Tatiana, Piacentino, Salvatore, Cristofanelli, Paolo, Mihalopoulos, Nikos, Kouvarakis, Giorgos, Pikridas, Michael, Savvides, Chrysanthos, Mamouri, Rodanthi-Elisavet, Nisantzi, Argyro, Hadjimitsis, Diofantos, Attié, Jean-Luc, Ferré, Hélène, Kangah, Yannick, Jaidan, Nizar, Guth, Jonathan, Jacquet, Patrick, Chevrier, Stéphane, Robert, Claude, Bourdon, Aurélien, Bourdinot, Jean-François, Etienne, Jean-Claude, Krysztofiak, Gisèle, and Theron, Pierre

Published
2018

11. EUREC<sup>4</sup>A observations from the SAFIRE ATR42 aircraft

Author

Bony, Sandrine, primary, Lothon, Marie, additional, Delanoë, Julien, additional, Coutris, Pierre, additional, Etienne, Jean-Claude, additional, Aemisegger, Franziska, additional, Albright, Anna Lea, additional, André, Thierry, additional, Bellec, Hubert, additional, Baron, Alexandre, additional, Bourdinot, Jean-François, additional, Brilouet, Pierre-Etienne, additional, Bourdon, Aurélien, additional, Canonici, Jean-Christophe, additional, Caudoux, Christophe, additional, Chazette, Patrick, additional, Cluzeau, Michel, additional, Cornet, Céline, additional, Desbios, Jean-Philippe, additional, Duchanoy, Dominique, additional, Flamant, Cyrille, additional, Fildier, Benjamin, additional, Gourbeyre, Christophe, additional, Guiraud, Laurent, additional, Jiang, Tetyana, additional, Lainard, Claude, additional, Le Gac, Christophe, additional, Lendroit, Christian, additional, Lernould, Julien, additional, Perrin, Thierry, additional, Pouvesle, Frédéric, additional, Richard, Pascal, additional, Rochetin, Nicolas, additional, Salaün, Kevin, additional, Schwarzenboeck, Alfons, additional, Seurat, Guillaume, additional, Stevens, Bjorn, additional, Totems, Julien, additional, Touzé-Peiffer, Ludovic, additional, Vergez, Gilles, additional, Vial, Jessica, additional, Villiger, Leonie, additional, and Vogel, Raphaela, additional

Published
2022
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13. Molecular profiling of advanced soft-tissue sarcomas: the MULTISARC randomized trial

Author

Italiano, Antoine, Dinart, Derek, Soubeyran, Isabelle, Bellera, Carine, Espérou, Hélène, Delmas, Christelle, Mercier, Noémie, Albert, Sabrina, Poignie, Ludivine, Boland, Anne, Bourdon, Aurélien, Geneste, Damien, Cavaille, Quentin, Laizet, Yec’han, Khalifa, Emmanuel, Auzanneau, Céline, Squiban, Barbara, Truffaux, Nathalène, Olaso, Robert, Gerber, Zuzana, Wallet, Cédrick, Bénard, Antoine, Blay, Jean-Yves, Laurent-Puig, Pierre, Deleuze, Jean-François, Lucchesi, Carlo, Mathoulin-Pelissier, Simone, Institut Bergonié [Bordeaux], UNICANCER, Actions for OnCogenesis understanding and Target Identification in ONcology (ACTION), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bordeaux Segalen - Bordeaux 2-Institut Bergonié [Bordeaux], UNICANCER-UNICANCER, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Pôle de Recherche Clinique [Paris] (PRC), Institut National de la Santé et de la Recherche Médicale (INSERM), Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS), Centre National de Recherche en Génomique Humaine (CNRGH), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), CHU Bordeaux [Bordeaux], Centre Léon Bérard [Lyon], Université Sorbonne Paris Cité (USPC), Université Paris Descartes - Paris 5 (UPD5), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Malbec, Odile, and UNICANCER-UNICANCER-Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Umbrella, Biomarker-driven, Time Factors, Cost-Benefit Analysis, [SDV]Life Sciences [q-bio], High-Throughput Nucleotide Sequencing, Sarcoma, Soft Tissue Neoplasms, Soft-tissue sarcomas, [SDV] Life Sciences [q-bio], Study Protocol, Sample Size, Next generation sequencing, Exome Sequencing, Feasibility Studies, Humans, France, Prospective Studies
Abstract

Background Soft-tissue sarcomas (STS) represent a heterogeneous group of rare tumors including more than 70 different histological subtypes. High throughput molecular analysis (next generation sequencing exome [NGS]) is a unique opportunity to identify driver mutations that can change the usual one-size-fits-all treatment paradigm to a patient-driven therapeutic strategy. The primary objective of the MULTISARC trial is to assess whether NGS can be conducted for a large proportion of metastatic STS participants within a reasonable time, and, secondarily to determine whether a NGS-guided therapeutic strategy improves participant’s outcome. Methods This is a randomized, multicentre, phase II/III trial inspired by the design of umbrella and biomarker-driven trials. The setting plans up to 17 investigational centres across France and the recruitment of 960 participants. Participants aged at least 18 years, with unresectable locally advanced and/or metastatic STS confirmed by the French sarcoma pathological reference network, are randomized according to 1:1 allocation ratio between the experimental arm “NGS” and the standard “No NGS”. NGS will be considered feasible if (i) NGS results are available and interpretable, and (ii) a report of exome sequencing including a clinical recommendation from a multidisciplinary tumor board is provided to investigators within 7 weeks from reception of the samples on the biopathological platform. A feasibility rate of more than 70% is expected (null hypothesis: 70% versus alternative hypothesis: 80%). In terms of care, participants randomized in “No NGS” arm and who fail treatment will be able to switch to the NGS arm at the request of the investigator. Discussion The MULTISARC trial is a prospective study designed to provide high-level evidence to support the implementation of NGS in routine clinical practice for advanced STS participants, on a large scale. Trial registration clinicaltrial.gov NCT03784014. Supplementary Information The online version contains supplementary material available at 10.1186/s12885-021-08878-2.

Published
2021
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14. EUREC4A observations from the SAFIRE ATR42 aircraft.

Author

Bony, Sandrine, Lothon, Marie, Delanoë, Julien, Coutris, Pierre, Etienne, Jean-Claude, Aemisegger, Franziska, Albright, Anna Lea, André, Thierry, Bellec, Hubert, Baron, Alexandre, Bourdinot, Jean-François, Brilouet, Pierre-Etienne, Bourdon, Aurélien, Canonici, Jean-Christophe, Caudoux, Christophe, Chazette, Patrick, Cluzeau, Michel, Cornet, Céline, Desbios, Jean-Philippe, and Duchanoy, Dominique

Subjects
MICROWAVE radiometers, DOPPLER radar, DOPPLER lidar, HYGROMETRY, RADIOMETERS, RESEARCH aircraft, HUMIDITY, FREE surfaces
Abstract

As part of the EUREC4A (Elucidating the role of cloud-circulation coupling in climate) field campaign, which took place in January and February 2020 over the western tropical Atlantic near Barbados, the French SAFIRE ATR42 research aircraft conducted 19 flights in the lower troposphere. Each flight followed a common flight pattern that sampled the atmosphere around the cloud-base level, at different heights of the subcloud layer, near the sea surface and in the lower free troposphere. The aircraft's payload included a backscatter lidar and a Doppler cloud radar that were both horizontally oriented, a Doppler cloud radar looking upward, microphysical probes, a cavity ring-down spectrometer for water isotopes, a multiwavelength radiometer, a visible camera and multiple meteorological sensors, including fast rate sensors for turbulence measurements. With this instrumentation, the ATR characterized the macrophysical and microphysical properties of trade-wind clouds together with their thermodynamical, turbulent and radiative environment. This paper presents the airborne operations, the flight segmentation, the instrumentation, the data processing and the EUREC4A datasets produced from the ATR measurements. It shows that the ATR measurements of humidity, wind and cloud-base cloud fraction measured with different techniques and samplings are internally consistent, that meteorological measurements are consistent with estimates from dropsondes launched from an overflying aircraft (HALO), and that water isotopic measurements are well correlated with data from the Barbados Cloud Observatory. This consistency demonstrates the robustness of the ATR measurements of humidity, wind, cloud-base cloud fraction and water isotopic composition during EUREC4A. It also confirms that through their repeated flight patterns, the ATR and HALO measurements provided a statistically consistent sampling of trade-wind clouds and of their environment. The ATR datasets are freely available at the locations specified in Table 11. [ABSTRACT FROM AUTHOR]

Published
2022
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16. PowerAPI : mesurer la consommation électrique des logiciels sans wattmètre

Author

Bourdon, Aurélien, Bordage, Frédéric, Adaptive Distributed Applications and Middleware (ADAM), Laboratoire d'Informatique Fondamentale de Lille (LIFL), Université de Lille, Sciences et Technologies-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lille, Sciences Humaines et Sociales-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Sciences et Technologies-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lille, Sciences Humaines et Sociales-Centre National de la Recherche Scientifique (CNRS)-Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria), and Chercheur indépendant

Subjects
[INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE]
Abstract

National audience; L'éco­conception d'un logiciel ou d'un site web permet de réaliser d'importantes économies d'énergie au sein des centres informatiques tout en allongeant la durée de vie active des postes utilisateurs. Cette démarche nécessite de mesurer finement la consommation en ressources ­ cycles processeur, espace disque, quantité de mémoire vive ­ des différentes parties du code d'un logiciel. C'est ce que propose la librairie PowerAPI. Mise au point par l'équipe ADAM de l'INRIA à Lille, PowerAPI permet de se passer d'un wattmètre. En libérant le développeur de la contrainte du wattmètre, cette librairie va accélérer la prise en compte des bonnes pratiques d'éco­conception logicielle. Echange avec Aurélien Bourdon qui pilote le projet au sein de l'équipe ADAM de l'INRIA.

Published
2013

17. Tumeurs mésenchymateuses utérines associées à translocation : du nouveau sans oublier l’ancien. Une approche diagnostique intégrée

Author

Fontanges, Quitterie, Truffaux, Nathalène, Azmani, Rihab, Bourdon, Aurélien, and Croce, Sabrina

Abstract

Cette revue se concentre sur les entités mésenchymateuses utérines présentant sur le plan moléculaire une altération unique, nécessaire et suffisante à la tumorigénèse et à la progression tumorale. L’ensemble de ces entités ont en commun ce que l’on nomme un profil génomique simple, terme recoupant l’absence de remaniements chromosomiques significatifs objectivables en CGH Array (délétions, gains, amplifications….) et un faible nombre de mutations (« low mutational burden »).

Published
2024
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