1. Efficacy and Safety of 0.1% Cyclosporine versus 2% Cyclosporine in the Treatment of Severe Vernal Keratoconjunctivitis in Children
- Author
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Bourcier T, Dory A, Dormegny L, Alcazar J, Gaucher D, and Sauer A
- Subjects
ciclosporine ,vernal keratococonjunctivitis ,Ophthalmology ,RE1-994 - Abstract
Tristan Bourcier,1 Anne Dory,2 Lea Dormegny,1 Joffrey Alcazar,1 David Gaucher,1 Arnaud Sauer1 1Department of Ophthalmology, Strasbourg University Hospital, University of Strasbourg, Strasbourg, France; 2Pharmacy, Strasbourg University Hospital, University of Strasbourg, Strasbourg, FranceCorrespondence: Arnaud Sauer, Department of Ophthalmology, Nouvel Hôpital Civil, Strasbourg University Hospital, BP426, Strasbourg, 67091, France, Email arnaud.sauer@chru-strasbourg.frIntroduction: Vernal keratoconjunctivitis (VKC) is an inflammatory condition in children that can cause severe eye complications. Treatment is based on corticosteroid therapy during flare-ups, then antihistamines and cyclosporine in calmer periods. The dosage and posology of cyclosporine are subject to debate.Methods: The aim of the study is to compare the evolution in symptomatic and clinical scores, and need for topical corticosteroid treatment in a population of children with severe VKC treated with two dosages of cyclosporine treatment (0.1% and 2%). Data were compiled on inclusion then every three months from March, with a total follow-up duration of 12 months. Data concerning patient evolutions and complications were collected for the two treatment groups.Results: The mean age of the 46 children was 8.8 ± 2.4 years with age at onset of symptoms of 5.1 ± 0.9 years. The cohort was predominantly (65%) male. Corticosteroid dependence on inclusion was present in 52% of the children included. A significant improvement in the various symptomatic and clinical scores was observed following treatment with cyclosporine (0.1% and 2%). Use of topical corticosteroid treatment reduced from 19 drops per month on inclusion to 4 drops per month at 12 months. Safety was comparable for the two groups.Conclusion: Treatments with cyclosporine 0.1% and 2% lead to a favourable evolution in clinical and symptomatic scores and reduced corticosteroid use. Cyclosporine 0.1% is an interesting alternative to the 2% dosage, particularly due to its availability and ease of handling.Keywords: cyclosporine, vernal keratoconjunctivitis
- Published
- 2022