322 results on '"Boulouis G"'
Search Results
2. P.029 Endovascular therapy for cerebral venous thrombosis: an international survey
- Author
-
Brakel, BA, primary, Rebchuk, AD, additional, Ospel, J, additional, Heran, MK, additional, Goyal, M, additional, Hill, MD, additional, Miao, Z, additional, Chen, Y, additional, Sacco, S, additional, Yaghi, S, additional, Ton, M, additional, Thomalla, G, additional, Boulouis, G, additional, Yamagami, H, additional, Campbell, BC, additional, Raymond, J, additional, Saposnik, G, additional, Nguyen, TN, additional, and Field, TS, additional
- Published
- 2024
- Full Text
- View/download PDF
3. AVC de l’enfant, imagerie diagnostique et thérapeutique
- Author
-
Naggara, O., Boulouis, G., Blauwblomme, T., Benichi, S., Kossorotoff, M., Meyer, P., Chevignard, M., Boddaert, N., and Brunelle, F.
- Published
- 2019
- Full Text
- View/download PDF
4. MRI for in vivo diagnosis of cerebral amyloid angiopathy: Tailoring artifacts to image hemorrhagic biomarkers
- Author
-
Boulouis, G., Edjlali-Goujon, M., Moulin, S., Ben Hassen, W., Naggara, O., Oppenheim, C., and Cordonnier, C.
- Published
- 2017
- Full Text
- View/download PDF
5. Unruptured intracranial aneurysms: An updated review of current concepts for risk factors, detection and management
- Author
-
Boulouis, G., Rodriguez-Régent, C., Rasolonjatovo, E.C., Ben Hassen, W., Trystram, D., Edjlali-Goujon, M., Meder, J.-F., Oppenheim, C., and Naggara, O.
- Published
- 2017
- Full Text
- View/download PDF
6. Diminution d'incidence des accidents vasculaires cérébraux ischémiques chez les patients âgés - PMSI Centre-Val de Loire, 2014-2022
- Author
-
Migeon, A., Lecuyer, A-I., Annan, M., Laribi, S., Pasi, M., Boulouis, G., Grammatico-Guillon, L., and Laurent, E.
- Published
- 2024
- Full Text
- View/download PDF
7. Imagerie du Moya-Moya
- Author
-
Ancelet, C., Boulouis, G., Blauwblomme, T., Kossorotoff, M., Rodriguez-Regent, C., Mellerio, C., Grevent, D., Meder, J.-F., Trystram, D., Oppenheim, C., Zerah, M., Puget, S., Sainte-Rose, C., Boddaert, N., Brunelle, F., and Naggara, O.
- Published
- 2015
- Full Text
- View/download PDF
8. Diagnostic non invasif des anévrismes intracrâniens
- Author
-
Rodriguez-Régent, C., Edjlali-Goujon, M., Trystram, D., Boulouis, G., Ben Hassen, W., Godon-Hardy, S., Nataf, F., Machet, A., Legrand, L., Ladoux, A., Mellerio, C., Souillard-Scemama, R., Oppenheim, C., Meder, J.-F., and Naggara, O.
- Published
- 2014
- Full Text
- View/download PDF
9. Non-invasive diagnosis of intracranial aneurysms
- Author
-
Rodriguez-Régent, C., Edjlali-Goujon, M., Trystram, D., Boulouis, G., Ben Hassen, W., Godon-Hardy, S., Nataf, F., Machet, A., Legrand, L., Ladoux, A., Mellerio, C., Souillard-Scemama, R., Oppenheim, C., Meder, J.-F., and Naggara, O.
- Published
- 2014
- Full Text
- View/download PDF
10. Flow Diversion for ICA Aneurysms with Compressive Neuro-Ophthalmologic Symptoms: Predictors of Morbidity, Mortality, and Incomplete Aneurysm Occlusion
- Author
-
Kaiser, D.P.O., Boulouis, G., Soize, S., Maus, V., Fischer, S., Lobsien, D., Klisch, J., Styczen, H., Deuschl, C., Abdullayev, N., Kabbasch, C., Jamous, A., Behme, D., Janot, K., Bellanger, G., Cognard, C., Pierot, L., Gawlitza, M., Manceau, Pierre-François, Sahnoun, Maher, Gelmini, Christophe, Bibi, Richard, Herbreteau, Denis, Ifergan, Heloïse, Bankolle, Nourou Dine Adeniran, and Linn, Jennifer
- Subjects
Interventional ,Endovascular Procedures ,Medizin ,Intracranial Aneurysm ,Middle Aged ,Embolization, Therapeutic ,Blood Vessel Prosthesis ,Treatment Outcome ,Humans ,Radiology, Nuclear Medicine and imaging ,Female ,Stents ,Neurology (clinical) ,Morbidity ,Retrospective Studies - Abstract
BACKGROUND AND PURPOSE: Flow diversion is an effective treatment for aneurysms of the ICA with compression-related neuro-ophthalmologic symptoms, especially when treatment is initiated early after symptom onset and aneurysm occlusion is complete. However, non-negligible complication rates have been reported. Our aim was to identify risk factors for morbidity/mortality and incomplete aneurysm occlusion. MATERIALS AND METHODS: We performed a secondary analysis of a previous publication, which included all patients treated with flow diversion for an unruptured aneurysm of the ICA with compression-related symptoms. RESULTS: Fifty-four patients with 54 aneurysms (48 women, 88.9%; mean age, 59.2 [SD, 15.9] years; range, 21–86 years) treated with flow diversion were included. We observed morbidity and mortality rates of 7.4% and 3.7%. Increasing age (OR per decade, 3.2; 95% CI, 1.23–8.49; P = .02) and dual-antiplatelet therapy with ticagrelor (OR, 13.9; 95% CI, 1.16–165.97; P = .04) were significantly associated with morbidity/mortality. After a median follow-up of 13.3 [SD, 10.5] months, the rates of complete aneurysm occlusion, neck remnant, and aneurysm remnant were 74%, 14%, and 12%. Incomplete occlusion at follow-up was less frequently observed in aneurysms treated with additional coil embolization (OR, 0.1; 95% CI, 0.01–0.86; P = .04). CONCLUSIONS: Although a promising treatment for compressive ICA aneurysms, flow diversion carries a relevant risk for complications and incomplete aneurysm occlusion. Our results may help identify patients in which flow diversion may not be the ideal treatment method. Additional coil embolization increased the likelihood of complete aneurysm occlusion at follow-up.
- Published
- 2022
11. Surgical or Endovascular Treatment of MCA Aneurysms: An Agreement Study
- Author
-
Boisseau, W., primary, Darsaut, T.E., additional, Fahed, R., additional, Findlay, J.M., additional, Bourcier, R., additional, Charbonnier, G., additional, Smajda, S., additional, Ognard, J., additional, Roy, D., additional, Gariel, F., additional, Carlson, A.P., additional, Shotar, E., additional, Ciccio, G., additional, Marnat, G., additional, Sporns, P.B., additional, Gaberel, T., additional, Jecko, V., additional, Weill, A., additional, Biondi, A., additional, Boulouis, G., additional, Bras, A.L., additional, Aldea, S., additional, Passeri, T., additional, Boissonneau, S., additional, Bougaci, N., additional, Gentric, J.C., additional, Diestro, J.D.B., additional, Omar, A.T., additional, Al-Jehani, H.M., additional, Hage, G. El, additional, Volders, D., additional, Kaderali, Z., additional, Tsogkas, I., additional, Magro, E., additional, Holay, Q., additional, Zehr, J., additional, Iancu, D., additional, and Raymond, J., additional
- Published
- 2022
- Full Text
- View/download PDF
12. Noninvasive Follow-up Imaging of Ruptured Pediatric Brain AVMs Using Arterial Spin-Labeling
- Author
-
Hak, J.F., primary, Boulouis, G., additional, Kerleroux, B., additional, Benichi, S., additional, Stricker, S., additional, Gariel, F., additional, Garzelli, L., additional, Meyer, P., additional, Kossorotoff, M., additional, Boddaert, N., additional, Girard, N., additional, Vidal, V., additional, Dangouloff Ros, V., additional, Blauwblomme, T., additional, and Naggara, O., additional
- Published
- 2022
- Full Text
- View/download PDF
13. Posterior National Institutes of Health Stroke Scale Improves Prognostic Accuracy in Posterior Circulation Stroke
- Author
-
Alemseged, Fana, primary, Rocco, Alessandro, additional, Arba, Francesco, additional, Schwabova, Jaroslava Paulasova, additional, Wu, Teddy, additional, Cavicchia, Leone, additional, Ng, Felix, additional, Ng, Jo Lyn, additional, Zhao, Henry, additional, Williams, Cameron, additional, Sallustio, Fabrizio, additional, Balabanski, Anna H., additional, Tomek, Ales, additional, Parson, Mark W., additional, Mitchell, Peter J., additional, Diomedi, Marina, additional, Yassi, Nawaf, additional, Churilov, Leonid, additional, Davis, Stephen M., additional, Campbell, Bruce C.V., additional, Parsons, M., additional, McDonald, A., additional, Pesavento, L., additional, Coote, S., additional, Yan, Bernard, additional, Dowling, Rick, additional, Bush, Steven, additional, Ng, F.C., additional, Thijs, V., additional, Kleinig, Timothy, additional, Drew, R., additional, Garcia Esperon, C., additional, Spratt, N., additional, Shah, D., additional, Wu, T., additional, Fink, J., additional, Di Giuliano, F., additional, Nappini, S., additional, Morotti, A., additional, Cavallini, A., additional, Boulouis, G., additional, Benhassen, W., additional, Puetz, V., additional, Kaiser, D., additional, Oxley, T.J., additional, and Fifi, J.T., additional
- Published
- 2022
- Full Text
- View/download PDF
14. Imagerie TDM et IRM à la phase aiguë des hématomes hépatiques non traumatiques inauguraux
- Author
-
Boulouis, G., Marmin, C., Lemaire, S., Boury, S., Sergent, G., Mordon, S., and Ernst, O.
- Published
- 2013
- Full Text
- View/download PDF
15. CT and MRI imaging at the acute phase of inaugural non-traumatic hepatic haemorrhages
- Author
-
Boulouis, G., Marmin, C., Lemaire, S., Boury, S., Sergent, G., Mordon, S., and Ernst, O.
- Published
- 2013
- Full Text
- View/download PDF
16. FLAIR Vascular Hyperintensities as a Surrogate of Collaterals in Acute Stroke: DWI Matters.
- Author
-
Legrand, L., Le Berre, A., Seners, P., Benzakoun, J., Hassen, W. Ben, Lion, S., Boulouis, G., Cottier, J.-P., Costalat, V., Bracard, S., Berthezene, Y., Ozsancak, C., Provost, C., Naggara, O., Baron, J.-C., Turc, G., and Oppenheim, C.
- Published
- 2023
- Full Text
- View/download PDF
17. Parent Artery Straightening after Flow-Diverter Stenting Improves the Odds of Aneurysm Occlusion
- Author
-
Janot, K., primary, Fahed, R., additional, Rouchaud, A., additional, Zuber, K., additional, Boulouis, G., additional, Forestier, G., additional, Mounayer, C., additional, and Piotin, M., additional
- Published
- 2021
- Full Text
- View/download PDF
18. Noninvasive Angiographic Results of Clipped or Coiled Intracranial Aneurysms: An Inter- and Intraobserver Reliability Study
- Author
-
Benomar, A., primary, Farzin, B., additional, Gevry, G., additional, Boisseau, W., additional, Roy, D., additional, Weill, A., additional, Iancu, D., additional, Guilbert, F., additional, Létourneau-Guillon, L., additional, Jacquin, G., additional, Chaalala, C., additional, Bojanowski, M.W., additional, Labidi, M., additional, Fahed, R., additional, Volders, D., additional, Nguyen, T.N., additional, Gentric, J.-C., additional, Magro, E., additional, Boulouis, G., additional, Forestier, G., additional, Hak, J.-F., additional, Ghostine, J.S., additional, Kaderali, Z., additional, Shankar, J.J., additional, Kotowski, M., additional, Darsaut, T.E., additional, and Raymond, J., additional
- Published
- 2021
- Full Text
- View/download PDF
19. Comment j’explore en imagerie un déficit neurologique brutal focal ?
- Author
-
Kerleroux, B., Boulouis, G., Oppenheim, C., and Boutet, C.
- Published
- 2021
- Full Text
- View/download PDF
20. Flow Diversion for ICA Aneurysms with Compressive Neuro-Ophthalmologic Symptoms: Predictors of Morbidity, Mortality, and Incomplete Aneurysm Occlusion.
- Author
-
Kaiser, D. P. O., Boulouis, G., Soize, S., Maus, V., Fischer, S., Lobsien, D., Klisch, J., Styczen, H., Deuschl, C., Abdullayev, N., Kabbasch, C., Jamous, A., Behme, D., Janot, K., Bellanger, G., Cognard, C., Pierot, L., and Gawlitza, M.
- Published
- 2022
- Full Text
- View/download PDF
21. Comment je fais une thrombectomie mécanique intracrânienne ?
- Author
-
Kerleroux, B., Shotar, E., Janot, K., Hak, J.F., Forestier, G., Naggara, O., Ben Hassen, W., and Boulouis, G.
- Published
- 2020
- Full Text
- View/download PDF
22. Comment je fais : une imagerie pour une céphalée en coup de tonnerre
- Author
-
Kerleroux, B., Boulouis, G., Oppenheim, C., and Boutet, C.
- Published
- 2020
- Full Text
- View/download PDF
23. Peak Width of Skeletonized Mean Diffusivity as Neuroimaging Biomarker in Cerebral Amyloid Angiopathy
- Author
-
Raposo, N., primary, Zanon Zotin, M.C., additional, Schoemaker, D., additional, Xiong, L., additional, Fotiadis, P., additional, Charidimou, A., additional, Pasi, M., additional, Boulouis, G., additional, Schwab, K., additional, Schirmer, M.D., additional, Etherton, M.R., additional, Gurol, M.E., additional, Greenberg, S.M., additional, Duering, M., additional, and Viswanathan, A., additional
- Published
- 2021
- Full Text
- View/download PDF
24. Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study
- Author
-
Kremer, S. (Stéphane), Boulay, C. (Clotilde), de Sèze, J. (Jérome), Ferré, J. (Jean-Christophe), Maamar, A. (Adel), Carsin-Nicol, B. (Béatrice), Collange, O. (Olivier), Bonneville, F. (Fabrice), Adam, G. (Gilles), Martin-Blondel, G. (Guillaume), Rafiq, M. (Marie), Geeraerts, T. (Thomas), Delamarre, L. (Louis), Grand, S. (Sylvie), Krainik, A. (Alexandre), Kremer, S. (Stephane), Alleg, M. (Manel), Anheim, M. (Mathieu), Anxionnat, R. (René), Ardellier, F. (François-Daniel), Baloglu, S. (Seyyid), Bapst, B. (Blanche), Benzakoun, J. (Joseph), Berge, J. (Jérome), Bolognini, F. (Federico), Bornet, G. (Grégoire), Boulouis, G. (Grégoire), Boutet, C. (Claire), Brisset, J. (Jean Christophe), Caillard-ohlmann, S. (Sophie), Carré, S. (Sophie), Comby, P. (Pierre-Olivier), Constans, J. (Jean Marc), David, J. (Jean-Stéphane), de Beaurepaire, I. (Isaure), De Seze, J. (Jerome), Desal, H. (Hubert), Edjlali-Goujon, M. (Myriam), Fabre, X. (Xavier), Fafi-Kremer, S. (Samira), Feuerstein, P. (Philippe), Henry Feugeas, M. (Marie-Cécile), Forestier, G. (Géraud), Gaudemer, A. (Augustin), Hansmann, Y. (Yves), Heintz, A. (Adrien), Boisrame, J. (Julie), Hemmert, C. (Céline), Hmeydia, G. (Ghazi), Jager, L. (Lavinia), Kazémi, A. (Apolline), Kerleroux, B. (Basile), Khalil, A. (Antoine), Lacalm, A. (Audrey), Lecler, A. (Augustin), Lecocq, C. (Claire), Lefebvre, N. (Nicolas), Lersy, F. (François), Matthieu, M. (Muriel), Megdiche, I. (Imen), Mertes, P. (Paul-michel), Messié, J. (Julien), Metanbou, S. (Serge), Meyer, N. (Nicolas), Meziani, F. (Ferhat), Mutschler, V. (Veronique), Nesser, P. (Patrick), Oesterlé, H. (Hélène), Ohana, M. (Mickaël), Oppenheim, C. (Catherine), Pyatigorskaya, N. (Nadya), Ricolfi, F. (Frédéric), Saleme, S. (Suzana), Schenck, M. (Maleka), Schmitt, E. (Emmanuelle), Schneider, F. (Francis), Sebag, N. (Nathan), Talla Mba, Y. (Yannick), Thouant, P. (Pierre), Willaume, T. (Thibault), Zhu, F. (François), Zorn, P. (Pierre-Emmanuel), Cotton, F. (François), Les Hôpitaux Universitaires de Strasbourg (HUS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Radiologie [CHU de Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], CHU Toulouse [Toulouse], CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Centre hospitalier de Haguenau, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Nancy (CHU Nancy), CHU Henri Mondor, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), CHU Bordeaux [Bordeaux], Hôpitaux Civils de Colmar, Hôpital Privé d'Antony, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Observatoire Français de la Sclérose En Plaques [Lyon] (OFSEP), Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Amiens-Picardie, Hospices Civils de Lyon (HCL), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Hospitalier de Roanne (CH Roanne), CH de Roanne, Groupe hospitalier de la région de Mulhouse Sud-Alsace (GHRMSA), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Limoges, CHU Strasbourg, Nouvel Hôpital Civil de Strasbourg, Université de Strasbourg (UNISTRA), Hôpital Marie-Madeleine [Forbach], CHU Lille, Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Les Hôptaux universitaires de Strasbourg (HUS), Nanomédecine Régénérative (NanoRegMed), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Henri Mondor [Créteil], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ferré, Jean-Christophe, and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Adult ,Male ,medicine.medical_specialty ,Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] ,Adolescent ,Pneumonia, Viral ,Gastroenterology ,030218 nuclear medicine & medical imaging ,Temporal lobe ,White matter ,Cohort Studies ,03 medical and health sciences ,symbols.namesake ,Betacoronavirus ,Young Adult ,0302 clinical medicine ,Cerebrospinal fluid ,Internal medicine ,Intensive care ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,10. No inequality ,Child ,Pandemics ,Fisher's exact test ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,SARS-CoV-2 ,[SCCO.NEUR]Cognitive science/Neuroscience ,[SCCO.NEUR] Cognitive science/Neuroscience ,Brain ,COVID-19 ,Retrospective cohort study ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,3. Good health ,Venous thrombosis ,medicine.anatomical_structure ,Neuroradiology ,030220 oncology & carcinogenesis ,symbols ,Female ,business ,Coronavirus Infections - Abstract
International audience; BackgroundBrain MRI parenchymal signal abnormalities have been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).PurposeTo describe the neuroimaging findings (excluding ischemic infarcts) in patients with severe coronavirus disease 2019 (COVID-19) infection.Materials and MethodsThis was a retrospective study of patients evaluated from March 23, 2020, to April 27, 2020, at 16 hospitals. Inclusion criteria were (a) positive nasopharyngeal or lower respiratory tract reverse transcriptase polymerase chain reaction assays, (b) severe COVID-19 infection defined as a requirement for hospitalization and oxygen therapy, (c) neurologic manifestations, and (d) abnormal brain MRI findings. Exclusion criteria were patients with missing or noncontributory data regarding brain MRI or brain MRI showing ischemic infarcts, cerebral venous thrombosis, or chronic lesions unrelated to the current event. Categorical data were compared using the Fisher exact test. Quantitative data were compared using the Student t test or Wilcoxon test. P < .05 represented a significant difference.ResultsThirty men (81%) and seven women (19%) met the inclusion criteria, with a mean age of 61 years ± 12 (standard deviation) (age range, 8–78 years). The most common neurologic manifestations were alteration of consciousness (27 of 37, 73%), abnormal wakefulness when sedation was stopped (15 of 37, 41%), confusion (12 of 37, 32%), and agitation (seven of 37, 19%). The most frequent MRI findings were signal abnormalities located in the medial temporal lobe in 16 of 37 patients (43%; 95% confidence interval [CI]: 27%, 59%), nonconfluent multifocal white matter hyperintense lesions seen with fluid-attenuated inversion recovery and diffusion-weighted sequences with variable enhancement, with associated hemorrhagic lesions in 11 of 37 patients (30%; 95% CI: 15%, 45%), and extensive and isolated white matter microhemorrhages in nine of 37 patients (24%; 95% CI: 10%, 38%). A majority of patients (20 of 37, 54%) had intracerebral hemorrhagic lesions with a more severe clinical presentation and a higher admission rate in intensive care units (20 of 20 patients [100%] vs 12 of 17 patients without hemorrhage [71%], P = .01) and development of the acute respiratory distress syndrome (20 of 20 patients [100%] vs 11 of 17 patients [65%], P = .005). Only one patient had SARS-CoV-2 RNA in the cerebrospinal fluid.ConclusionPatients with severe coronavirus disease 2019 and without ischemic infarcts had a wide range of neurologic manifestations that were associated with abnormal brain MRI scans. Eight distinctive neuroradiologic patterns were described.
- Published
- 2020
25. Risk Factors for Early Brain AVM Rupture: Cohort Study of Pediatric and Adult Patients
- Author
-
Garzelli, L., primary, Shotar, E., additional, Blauwblomme, T., additional, Sourour, N., additional, Alias, Q., additional, Stricker, S., additional, Mathon, B., additional, Kossorotoff, M., additional, Gariel, F., additional, Boddaert, N., additional, Brunelle, F., additional, Meyer, P., additional, Naggara, O., additional, Clarençon, F., additional, and Boulouis, G., additional
- Published
- 2020
- Full Text
- View/download PDF
26. Benefit of first‐pass complete reperfusion in thrombectomy is mediated by limited infarct growth
- Author
-
Ben Hassen, W., primary, Tordjman, M., additional, Boulouis, G., additional, Bretzner, M., additional, Bricout, N., additional, Legrand, L., additional, Benzakoun, J., additional, Edjlali, M., additional, Seners, P., additional, Cordonnier, C., additional, Oppenheim, C., additional, Turc, G., additional, Henon, H., additional, and Naggara, O., additional
- Published
- 2020
- Full Text
- View/download PDF
27. Parent Artery Straightening after Flow-Diverter Stenting Improves the Odds of Aneurysm Occlusion.
- Author
-
Janot, K., Fahed, R., Rouchaud, A., Zuber, K., Boulouis, G., Forestier, G., Mounayer, C., and Piotin, M.
- Published
- 2022
- Full Text
- View/download PDF
28. Hydrocéphalie après rupture de malformation artério-veneuse cérébrale chez l’enfant
- Author
-
Stricker, S., primary, Boulouis, G., additional, Benichi, S., additional, Gariel, F., additional, Garzelli, L., additional, Beccaria, K., additional, Chivet, A., additional, de Saint Denis, T., additional, James, S., additional, Paternoster, G., additional, Zerah, M., additional, Bourgeois, M., additional, Boddaert, N., additional, Brunelle, F., additional, Meyer, P., additional, Puget, S., additional, Naggara, O., additional, and Blauwblomme, T., additional
- Published
- 2020
- Full Text
- View/download PDF
29. Incidental Brain MRI Findings in Children: A Systematic Review and Meta-Analysis
- Author
-
Dangouloff-Ros, V., primary, Roux, C.-J., additional, Boulouis, G., additional, Levy, R., additional, Nicolas, N., additional, Lozach, C., additional, Grevent, D., additional, Brunelle, F., additional, Boddaert, N., additional, and Naggara, O., additional
- Published
- 2019
- Full Text
- View/download PDF
30. Verbal memory and sentence comprehension in aphasia: a case series
- Author
-
Varkanitsa, M., Kasselimis, D., Boulouis, G., Fugard, Andi, Evdokimidis, I., Druks, J., Potagas, C., and Van de Koot, H.
- Subjects
psysoc - Abstract
This case series explores the relationship between verbal memory capacity and sentence comprehension in four patients with aphasia. Two sentence comprehension tasks showed that two patients, P1 and P2, had impaired syntactic comprehension, whereas P3 and P4’s sentence comprehension was intact. The memory assessment tasks showed that P1 and P2 had severely impaired short-term memory, whereas P3 and P4 performed within the normal range in the short-term memory tasks. This finding suggests an association between short-term memory deficit and sentence comprehension difficulties. P1 and P3 exhibited impaired comparable working memory deficits, suggesting a dissociation between working memory and sentence comprehension.
- Published
- 2019
31. Distal Balloon Angioplasty of Cerebral Vasospasm Decreases the Risk of Delayed Cerebral Infarction
- Author
-
Labeyrie, M.-A., primary, Gaugain, S., additional, Boulouis, G., additional, Zetchi, A., additional, Brami, J., additional, Saint-Maurice, J.-P., additional, Civelli, V., additional, Froelich, S., additional, and Houdart, E., additional
- Published
- 2019
- Full Text
- View/download PDF
32. E-065 Ruptured brain arterio-venous malformations in children and adults: angioarchitectural variations at presentation across the lifespan
- Author
-
Garzelli, L, primary, Shotar, E, additional, Blauwblomme, T, additional, Sourour, N, additional, Alias, Q, additional, Mathon, B, additional, Kossorotoff, M, additional, Degos, V, additional, Gariel, F, additional, Boddaert, N, additional, Brunelle, F, additional, Meyer, P, additional, Naggara, O, additional, Clarençon, F, additional, and Boulouis, G, additional
- Published
- 2019
- Full Text
- View/download PDF
33. E-047 Vessel wall imaging and brain arteriovenous malformations: initial description of enhancement patterns
- Author
-
Garzelli, L, primary, Boulouis, G, additional, Blauwblomme, T, additional, Levy, R, additional, Boddaert, N, additional, Ben Hassen, W, additional, Trystram, D, additional, Rodriguez, C, additional, Dangouloff-Ross, V, additional, Nataf, F, additional, Oppenheim, C, additional, Brunelle, F, additional, Edjlali-Goujon, M, additional, and Naggara, O, additional
- Published
- 2019
- Full Text
- View/download PDF
34. Clot Burden Score and Collateral Status and Their Impact on Functional Outcome in Acute Ischemic Stroke.
- Author
-
Derraz, I., Pou, M., Labreuche, J., Legrand, L, Soize, S., Tisserand, M., Rosso, C., Piotin, M., Boulouis, G., Oppenheim, C., Naggara, O., Bracard, S., Clarençon, F., Lapergue, B., and Bourcie, R.
- Published
- 2021
- Full Text
- View/download PDF
35. Benefit of first‐pass complete reperfusion in thrombectomy is mediated by limited infarct growth.
- Author
-
Ben Hassen, W., Tordjman, M., Boulouis, G., Bretzner, M., Bricout, N., Legrand, L., Benzakoun, J., Edjlali, M., Seners, P., Cordonnier, C., Oppenheim, C., Turc, G., Henon, H., and Naggara, O.
- Subjects
DIFFUSION magnetic resonance imaging ,THROMBECTOMY ,REPERFUSION ,CEREBRAL infarction - Abstract
Background and Purpose: The number of clot retrieval attempts required to achieve complete reperfusion by mechanical thrombectomy impacts functional outcome in acute ischaemic stroke (AIS). Complete reperfusion [expanded Treatment In Cerebral Infarction (eTICI) score = 3] at first pass (FP), is associated with the highest rates of favorable outcome compared to complete reperfusion by multiple passes. The aim of the present study was to investigate the relationship between FP complete reperfusion and infarct growth (IG). Methods: Anterior AIS patients with baseline and 24‐h diffusion‐weighted magnetic resonance imaging were included from two prospective registries. IG was measured by voxel‐based segmentation of initial and 24‐h diffusion‐weighted imaging lesions. IG and favorable 3‐month modified Rankin Scale (mRS) score (≤ 2) were compared between patients in whom complete reperfusion (eTICI 3) was achieved with a single pass (FP group) and those for whom multiple passes were required (MP group), after matching for confounding factors. Mediation analysis was performed to examine the association between FP and 3‐month mRS score, with IG as mediating variable. Results: A total of 200 patients were included, of whom 118 (28.9%) had FP complete reperfusion. In case–control analysis, the FP group had lower IG than the MP group [8.7 (5.4–12.9) ml vs. 15.2 (11–22.6) ml, respectively; P = 0.03). Favorable outcome was higher in the FP population compared to a matched MP population (70.9% vs. 53.2%, respectively; P = 0.04). FP compete reperfusion (eTICI 3) was independently associated with favorable outcome in multivariable regression analysis [odds ratio 1.86, 95% confidence interval (CI) 1.01–4.39; P = 0.04]. The effect of complete reperfusion at FP on functional outcome was explained by limited IG in mediation analysis [indirect effect: −0.32 (95% CI −0.47 to −0.09)]. Conclusion: Complete reperfusion at FP is independently associated with significant decrease in IG compared to complete reperfusion by multiple attempts, explaining better functional outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
36. Consensus Needed for Noncontrast CT Markers in Intracerebral Hemorrhage
- Author
-
Boulouis, G., primary, Charidimou, A., additional, and Morotti, A., additional
- Published
- 2018
- Full Text
- View/download PDF
37. Concordance of Time-of-Flight MRA and Digital Subtraction Angiography in Adult Primary Central Nervous System Vasculitis
- Author
-
de Boysson, H., primary, Boulouis, G., additional, Parienti, J.-J., additional, Touzé, E., additional, Zuber, M., additional, Arquizan, C., additional, Dequatre, N., additional, Detante, O., additional, Bienvenu, B., additional, Aouba, A., additional, Guillevin, L., additional, Pagnoux, C., additional, and Naggara, O., additional
- Published
- 2017
- Full Text
- View/download PDF
38. Arterial Spin-Labeling to Discriminate Pediatric Cervicofacial Soft-Tissue Vascular Anomalies
- Author
-
Boulouis, G., primary, Dangouloff-Ros, V., additional, Boccara, O., additional, Garabedian, N., additional, Soupre, V., additional, Picard, A., additional, Couloigner, V., additional, Boddaert, N., additional, Naggara, O., additional, and Brunelle, F., additional
- Published
- 2017
- Full Text
- View/download PDF
39. Vascularites primitives du système nerveux central : la taille des vaisseaux concernés définit des sous-groupes bien distincts de la maladie
- Author
-
De Boysson, H., primary, Boulouis, G., additional, Aouba, A., additional, Bienvenu, B., additional, Guillevin, L., additional, Zuber, M., additional, Touzé, E., additional, Naggara, O., additional, and Pagnoux, C., additional
- Published
- 2016
- Full Text
- View/download PDF
40. Vascularites primitives du système nerveux central : l’utilisation d’un traitement d’entretien améliore les résultats à long terme
- Author
-
De Boysson, H., primary, Parienti, J.J., additional, Arquizan, C., additional, Boulouis, G., additional, Bienvenu, B., additional, Aouba, A., additional, Naggara, O., additional, Régent, A., additional, Touzé, E., additional, Guillevin, L., additional, Zuber, M., additional, and Pagnoux, C., additional
- Published
- 2016
- Full Text
- View/download PDF
41. Les formes pseudo-tumorales de vascularite primitive du système nerveux central
- Author
-
De Boysson, H., primary, Boulouis, G., additional, Néel, A., additional, Arquizan, C., additional, Detante, O., additional, Zuber, M., additional, Touzé, E., additional, Aouba, A., additional, Bienvenu, B., additional, Guillevin, L., additional, Naggara, O., additional, and Pagnoux, C., additional
- Published
- 2016
- Full Text
- View/download PDF
42. Facteurs pronostics d’évolution clinique favorable à 3 mois des patients pris en charge par voie endovasculaire pour un AVC ischémique de la circulation antérieure
- Author
-
Aguettaz, P., primary, Hénon, H., additional, Boulouis, G., additional, Boustia, F., additional, Kalsoum, E., additional, and Leclerc, X., additional
- Published
- 2014
- Full Text
- View/download PDF
43. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size.
- Author
-
Costalat, V., Jovin, T. G., Albucher, J. F., Cognard, C., Henon, H., Nouri, N., Gory, B., Richard, S., Marnat, G., Sibon, I., Di Maria, F., Annan, M., Boulouis, G., Cardona, P., Obadia, M., Piotin, M., Bourcier, R., Guidon, B., Godard, S., and Pasco-Papon, A.
- Subjects
- *
THROMBOLYTIC therapy , *THROMBECTOMY , *STROKE , *MYOCARDIAL reperfusion , *INTRACEREBRAL hematoma , *LACUNAR stroke , *MAGNETIC resonance imaging , *CEREBRAL hemorrhage , *ENDOVASCULAR surgery - Abstract
BACKGROUND The use of thrombectomy in patients with acute stroke and a large infarct of unrestricted size has not been well studied. METHODS We assigned, in a 1:1 ratio, patients with proximal cerebral vessel occlusion in the anterior circulation and a large infarct (as defined by an Alberta Stroke Program Early Computed Tomographic Score of <5; values range from 0 to 10) detected on magnetic resonance imaging or computed tomography within 6.5 hours after symptom onset to undergo endovascular thrombectomy and receive medical care (thrombectomy group) or to receive medical care alone (control group). The primary outcome was the score on the modified Rankin scale at 90 days (scores range from 0 to 6, with higher scores indicating greater disability). The primary safety outcome was death from any cause at 90 days, and an ancillary safety outcome was symptomatic intracerebral hemorrhage. RESULTS A total of 333 patients were assigned to either the thrombectomy group (166 patients) or the control group (167 patients); 9 were excluded from the analysis because of consent withdrawal or legal reasons. The trial was stopped early because results of similar trials favored thrombectomy. Approximately 35% of the patients received thrombolysis therapy. The median modified Rankin scale score at 90 days was 4 in the thrombectomy group and 6 in the control group (generalized odds ratio, 1.63; 95% confidence interval [CI], 1.29 to 2.06; P<0.001). Death from any cause at 90 days occurred in 36.1% of the patients in the thrombectomy group and in 55.5% of those in the control group (adjusted relative risk, 0.65; 95% CI, 0.50 to 0.84), and the percentage of patients with symptomatic intracerebral hemorrhage was 9.6% and 5.7%, respectively (adjusted relative risk, 1.73; 95% CI, 0.78 to 4.68). Eleven procedure-related complications occurred in the thrombectomy group. CONCLUSIONS In patients with acute stroke and a large infarct of unrestricted size, thrombectomy plus medical care resulted in better functional outcomes and lower mortality than medical care alone but led to a higher incidence of symptomatic intracerebral hemorrhage. (Funded by Montpellier University Hospital; LASTE ClinicalTrials.gov number, NCT03811769.) [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
44. Remote Training of Neurointerventions by Audiovisual Streaming
- Author
-
Hanning, Uta, Bechstein, Matthias, Kaesmacher, Johannes, Boulouis, Grégoire, Chapot, René, Andersson, Tommy, De Dios Lascuevas, Marta, Institut Català de la Salut, [Hanning U, Bechstein M] Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [Kaesmacher J] Department of Neurology, Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, Bern, Switzerland. [Boulouis G] Diagnostic and Interventional Neuroradiology Department, Institut national de la santé et de la recherche médicale (INSERM) Team 1253 iBrain, Tours University Hospital, Tours, Centre Val de Loire Region, France. [Chapot R] Department of Neuroradiology, Alfried Krupp Krankenhaus, Essen, Germany. [Andersson T] Department of Neuroradiology, Karolinska University Hospital and Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. Department of Medical Imaging, AZ Groeninge, Kortrijk, Belgium. [de Dios Lascuevas M] Grup de Recerca de Neuroradiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
- Subjects
Health Care Economics and Organizations::Economics::Financial Support::Training Support::Fellowships and Scholarships [HEALTH CARE] ,intervenciones quirúrgicas::procedimientos quirúrgicos cardiovasculares::procedimientos quirúrgicos vasculares::procedimientos endovasculares [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke [DISEASES] ,Vasos sanguinis - Cirurgia ,Formació ,Beques ,economía y organizaciones para la atención de la salud::economía::apoyo financiero::financiación de la formación::becas [ATENCIÓN DE SALUD] ,enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular [ENFERMEDADES] ,Surgical Procedures, Operative::Cardiovascular Surgical Procedures::Vascular Surgical Procedures::Endovascular Procedures [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Malalties cerebrovasculars - Abstract
Telemedicine; Neuroendovascular training; Stroke Telemedicina; Formación neuroendovascular; Ictus Telemedicina; Formació neuroendovascular; Ictus Background Remote access of trainees to training centers via video streaming (tele-observership, e‑fellowship) emerges as an alternative to acquire knowledge in endovascular interventions. Situational awareness is a summary term that is also used in surgical procedures for perceiving and understanding the situation and projecting what will happen next. A high situational awareness would serve as prerequisite for meaningful learning success during tele-observerships. We hypothesized that live perception of the angiographical procedures using streaming technology is feasible and sufficient to gain useful situational awareness of the procedure. Methods During a European tele-observership organized by the European Society of Minimally Invasive Neurological Therapy (ESMINT) and its trainee association (EYMINT), a total of six neurointerventional fellows in five countries observed live cases performed by experienced neurointerventionalists (mentors) in six different high-volume neurovascular centers across Europe equipped with live-streaming technology (Tegus Medical, Hamburg, Germany). Cases were prospectively evaluated during a 12-month period, followed by a final questionnaire after completion of the course. Results A total of 102/161 (63%) cases with a 1:1 allocation of fellow and mentor were evaluated during a 12-month period. Most frequent conditions were ischemic stroke (27.5%), followed by embolization of unruptured aneurysms (25.5%) and arteriovenous malformations (AVMs) (15.7%). A high level of situational awareness was reported by fellows in 75.5% of all cases. After finishing the program, the general improvement of neurointerventional knowledge was evaluated to be extensive (1/6 fellows), substantial (3/6), and moderate (2/6). The specific fields of improvement were procedural knowledge (6/6 fellows), technical knowledge (3/6) and complication management (2/6). Conclusion Online streaming technology facilitates location-independent training of complex neurointerventional procedures through high levels of situational awareness and can therefore supplement live hands-on-training. In addition, it leads to a training effect for fellows with a perceived improvement of their neurointerventional knowledge. Open Access funding enabled and organized by Projekt DEAL.
- Published
- 2022
45. The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study
- Author
-
Andreas Charidimou, Gregoire Boulouis, Matthew P Frosch, Jean-Claude Baron, Marco Pasi, Jean Francois Albucher, Gargi Banerjee, Carmen Barbato, Fabrice Bonneville, Sebastian Brandner, Lionel Calviere, François Caparros, Barbara Casolla, Charlotte Cordonnier, Marie-Bernadette Delisle, Vincent Deramecourt, Martin Dichgans, Elif Gokcal, Jochen Herms, Mar Hernandez-Guillamon, Hans Rolf Jäger, Zane Jaunmuktane, Jennifer Linn, Sergi Martinez-Ramirez, Elena Martínez-Sáez, Christian Mawrin, Joan Montaner, Solene Moulin, Jean-Marc Olivot, Fabrizio Piazza, Laurent Puy, Nicolas Raposo, Mark A Rodrigues, Sigrun Roeber, Jose Rafael Romero, Neshika Samarasekera, Julie A Schneider, Stefanie Schreiber, Frank Schreiber, Corentin Schwall, Colin Smith, Levente Szalardy, Pascale Varlet, Alain Viguier, Joanna M Wardlaw, Andrew Warren, Frank A Wollenweber, Marialuisa Zedde, Mark A van Buchem, M Edip Gurol, Anand Viswanathan, Rustam Al-Shahi Salman, Eric E Smith, David J Werring, Steven M Greenberg, Charidimou, A, Boulouis, G, Frosch, M, Baron, J, Pasi, M, Albucher, J, Banerjee, G, Barbato, C, Bonneville, F, Brandner, S, Calviere, L, Caparros, F, Casolla, B, Cordonnier, C, Delisle, M, Deramecourt, V, Dichgans, M, Gokcal, E, Herms, J, Hernandez-Guillamon, M, Jäger, H, Jaunmuktane, Z, Linn, J, Martinez-Ramirez, S, Martínez-Sáez, E, Mawrin, C, Montaner, J, Moulin, S, Olivot, J, Piazza, F, Puy, L, Raposo, N, Rodrigues, M, Roeber, S, Romero, J, Samarasekera, N, Schneider, J, Schreiber, S, Schreiber, F, Schwall, C, Smith, C, Szalardy, L, Varlet, P, Viguier, A, Wardlaw, J, Warren, A, Wollenweber, F, Zedde, M, van Buchem, M, Gurol, M, Viswanathan, A, Al-Shahi Salman, R, Smith, E, Werring, D, and Greenberg, S
- Subjects
diagnoisi ,Amyloid beta-Peptides ,pathology [Cerebral Hemorrhage] ,Middle Aged ,MED/46 - SCIENZE TECNICHE DI MEDICINA DI LABORATORIO ,Magnetic Resonance Imaging ,diagnostic imaging [Cerebral Amyloid Angiopathy] ,Cerebral Amyloid Angiopathy ,methods [Magnetic Resonance Imaging] ,biomarker ,Humans ,Neurology (clinical) ,ddc:610 ,Neuropathology ,MRI ,Aged ,Cerebral Hemorrhage ,Retrospective Studies - Abstract
BACKGROUND: Cerebral amyloid angiopathy (CAA) is an age-related small vessel disease, characterised pathologically by progressive deposition of amyloid β in the cerebrovascular wall. The Boston criteria are used worldwide for the in-vivo diagnosis of CAA but have not been updated since 2010, before the emergence of additional MRI markers. We report an international collaborative study aiming to update and externally validate the Boston diagnostic criteria across the full spectrum of clinical CAA presentations.METHODS: In this multicentre, hospital-based, retrospective, MRI and neuropathology diagnostic accuracy study, we did a retrospective analysis of clinical, radiological, and histopathological data available to sites participating in the International CAA Association to formulate updated Boston criteria and establish their diagnostic accuracy across different populations and clinical presentations. Ten North American and European academic medical centres identified patients aged 50 years and older with potential CAA-related clinical presentations (ie, spontaneous intracerebral haemorrhage, cognitive impairment, or transient focal neurological episodes), available brain MRI, and histopathological assessment for CAA diagnosis. MRI scans were centrally rated at Massachusetts General Hospital (Boston, MA, USA) for haemorrhagic and non-haemorrhagic CAA markers, and brain tissue samples were rated by neuropathologists at the contributing sites. We derived the Boston criteria version 2.0 (v2.0) by selecting MRI features to optimise diagnostic specificity and sensitivity in a prespecified derivation cohort (Boston cases 1994-2012, n=159), then externally validated the criteria in a prespecified temporal validation cohort (Boston cases 2012-18, n=59) and a geographical validation cohort (non-Boston cases 2004-18; n=123), comparing accuracy of the new criteria to the currently used modified Boston criteria with histopathological assessment of CAA as the diagnostic standard. We also assessed performance of the v2.0 criteria in patients across all cohorts who had the diagnostic gold standard of brain autopsy.FINDINGS: The study protocol was finalised on Jan 15, 2017, patient identification was completed on Dec 31, 2018, and imaging analyses were completed on Sept 30, 2019. Of 401 potentially eligible patients presenting to Massachusetts General Hospital, 218 were eligible to be included in the analysis; of 160 patient datasets from other centres, 123 were included. Using the derivation cohort, we derived provisional criteria for probable CAA requiring the presence of at least two strictly lobar haemorrhagic lesions (ie, intracerebral haemorrhages, cerebral microbleeds, or foci of cortical superficial siderosis) or at least one strictly lobar haemorrhagic lesion and at least one white matter characteristic (ie, severe visible perivascular spaces in centrum semiovale or white matter hyperintensities in a multispot pattern). The sensitivity and specificity of these criteria were 74·8% (95% CI 65·4-82·7) and 84·6% (71·9-93·1) in the derivation cohort, 92·5% (79·6-98·4) and 89·5% (66·9-98·7) in the temporal validation cohort, 80·2% (70·8-87·6) and 81·5% (61·9-93·7) in the geographical validation cohort, and 74·5% (65·4-82·4) and 95·0% (83·1-99·4) in all patients who had autopsy as the diagnostic standard. The area under the receiver operating characteristic curve (AUC) was 0·797 (0·732-0·861) in the derivation cohort, 0·910 (0·828-0·992) in the temporal validation cohort, 0·808 (0·724-0·893) in the geographical validation cohort, and 0·848 (0·794-0·901) in patients who had autopsy as the diagnostic standard. The v2.0 Boston criteria for probable CAA had superior accuracy to the current Boston criteria (sensitivity 64·5% [54·9-73·4]; specificity 95·0% [83·1-99·4]; AUC 0·798 [0·741-0854]; p=0·0005 for comparison of AUC) across all individuals who had autopsy as the diagnostic standard.INTERPRETATION: The Boston criteria v2.0 incorporate emerging MRI markers of CAA to enhance sensitivity without compromising their specificity in our cohorts of patients aged 50 years and older presenting with spontaneous intracerebral haemorrhage, cognitive impairment, or transient focal neurological episodes. Future studies will be needed to determine generalisability of the v.2.0 criteria across the full range of patients and clinical presentations.FUNDING: US National Institutes of Health (R01 AG26484).
- Published
- 2021
46. Discovering the Italian phenotype of cerebral amyloid angiopathy (CAA): the SENECA project
- Author
-
Fabrizio Piazza, Paolo Vitali, Silvia Lanfranconi, Marcella Catania, Carlo Ferrarese, Alessandra Erbetta, Cristina Motto, Luisa Chiapparini, M. Gasparini, Simona Sacco, Gregoire Boulouis, G. Tremolada, J. C. Di Francesco, Eugenio Parati, Emma Scelzo, Andrea Morotti, Marialuisa Zedde, Paola Caroppo, G. Di Fede, Giorgio Giaccone, Andreas Charidimou, Francesca Tinelli, M. Di Girolamo, Laura Obici, Laura Gatti, L. Adobbati, Michelangelo Mancuso, M. Godani, Davide Pareyson, Stefania Bianchi-Marzoli, Leonardo Pantoni, Anna Bersano, Bersano, A, Scelzo, E, Pantoni, L, Morotti, A, Erbetta, A, Chiapparini, L, Vitali, P, Giaccone, G, Caroppo, P, Catania, M, Obici, L, Di Fede, G, Gatti, L, Tinelli, F, Di Francesco, J, Piazza, F, Ferrarese, C, Gasparini, M, Adobbati, L, Bianchi-Marzoli, S, Tremolada, G, Sacco, S, Mancuso, M, Zedde, M, Godani, M, Lanfranconi, S, Pareyson, D, Di Girolamo, M, Motto, C, Charidimou, A, Boulouis, G, and Parati, E
- Subjects
Cortical superficial siderosis ,medicine.medical_specialty ,Neurology ,Neuroimaging ,Dermatology ,Disease ,MED/46 - SCIENZE TECNICHE DI MEDICINA DI LABORATORIO ,Angiopathy ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Biomarkers ,Cerebral amyloid angiopathy ,Dementia ,Intracerebral hemorrhage ,Microbleeds ,Small vessel disease ,medicine ,Humans ,030212 general & internal medicine ,Cognitive decline ,Intensive care medicine ,Aged ,Cerebral Hemorrhage ,business.industry ,Cerebral Amyloid Angiopathy, Biomarkers, Dementia, Intracerebral hemorrhage, Neuroimaging, Microbleeds, Cortical superficial siderosis, Small vessel disease ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,Phenotype ,Italy ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Cohort study - Abstract
Cerebral amyloid angiopathy (CAA) is one of the major types of cerebral small vessel disease, and a leading cause of spontaneous intracerebral hemorrhage and cognitive decline in elderly patients. Although increasingly detected, a number of aspects including the pathophysiology, the clinical and neuroradiological phenotype, and the disease course are still under investigation. The incomplete knowledge of the disease limits the implementation of evidence-based guidelines on patient's clinical management and the development of treatments able to prevent or reduce disease progression. The SENECA (SEarchiNg biomarkErs of Cerebral Angiopathy) project is the first Italian multicenter cohort study aimed at better defining the disease natural history and identifying clinical and neuroradiological markers of disease progression. By a multidisciplinary approach and the collection of a large and well-phenotyped series and biorepository of CAA patients, the study is ultimately expected to improve the diagnosis and the knowledge of CAA pathophysiological mechanisms.
- Published
- 2020
47. Validation of Clinicoradiological Criteria for the Diagnosis of Cerebral Amyloid Angiopathy-Related Inflammation
- Author
-
Ashkan Shoamanesh, Ellis S. van Etten, Matthew P. Frosch, M. Edip Gurol, Jun Ni, Anand Viswanathan, Gregoire Boulouis, Fabrizio Piazza, Jacopo C. DiFrancesco, Sergi Martinez-Ramirez, Eitan Auriel, Octάvio M. Pontes-Neto, Kristin M. Schwab, Andreas Charidimou, Anastasia Vashkevich, Alison M. Ayres, Steven M. Greenberg, Yael D. Reijmer, Auriel, E, Charidimou, A, Gurol, M, Ni, J, Van Etten, E, Martinez Ramirez, S, Boulouis, G, Piazza, F, Frosch, M, Pontes Neto, O, Shoamanesh, A, Reijmer, Y, Vashkevich, A, Ayres, A, Schwab, K, Viswanathan, A, Greenberg, S, and Difrancesco, J
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Fluid-attenuated inversion recovery ,MED/50 - SCIENZE TECNICHE MEDICHE APPLICATE ,White matter ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,mental disorders ,medicine ,Humans ,cardiovascular diseases ,BIO/14 - FARMACOLOGIA ,MED/05 - PATOLOGIA CLINICA ,Aged ,Cerebral Hemorrhage ,Retrospective Studies ,Aged, 80 and over ,Inflammation ,Intracerebral hemorrhage ,medicine.diagnostic_test ,business.industry ,Brain biopsy ,MED/04 - PATOLOGIA GENERALE ,nutritional and metabolic diseases ,Retrospective cohort study ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Hyperintensity ,Surgery ,Radiography ,Cerebral Amyloid Angiopathy ,030104 developmental biology ,medicine.anatomical_structure ,Female ,Neurology (clinical) ,Cerebral amyloid angiopathy ,business ,cerebral amyloid angiopathy, cerebral amyloid angiopathy-related inflammation ,030217 neurology & neurosurgery - Abstract
Importance Cerebral amyloid angiopathy–related inflammation (CAA-ri) is an important diagnosis to reach in clinical practice because many patients with the disease respond to immunosuppressive therapy. Reliable noninvasive diagnostic criteria for CAA-ri would allow some patients to avoid the risk of brain biopsy. Objective To test the sensitivity and specificity of clinical and neuroimaging-based criteria for CAA-ri. Design, Setting, and Participants We modified the previously proposed clinicoradiological criteria and retrospectively analyzed clinical medical records and magnetic resonance imaging fluid-attenuated inversion recovery and gradient-echo scans obtained from individuals with CAA-ri and noninflammatory CAA. At 2 referral centers between October 1, 1995, and May 31, 2013, and between January 1, 2009, and December 31, 2011, participants included 17 individuals with pathologically confirmed CAA-ri and 37 control group members with pathologically confirmed noninflammatory CAA. The control group was further divided into those with past lobar intracerebral hemorrhage (ICH) (n = 21) and those with cerebral microbleeds only and no history of ICH (n = 16). The dates of our analysis were September 1, 2012, to August 31, 2015. Main Outcomes and Measures The sensitivity and specificity of prespecified criteria for probable CAA-ri (requiring asymmetric white matter hyperintensities extending to the subcortical white matter) and possible CAA-ri (not requiring the white matter hyperintensities to be asymmetric). Results The 17 patients in the CAA-ri group were a mean (SD) of 68 (8) years and 8 (47%) were women. In the CAA-ri group, 14 of 17 (82%) met the criteria for both probable and possible CAA-ri. In the control group having noninflammatory CAA with lobar ICH, 1 of 21 (5%) met the criteria for possible CAA-ri, and none met the criteria for probable CAA-ri. In the control group having noninflammatory CAA with no ICH, 11 of 16 (69%) met the criteria for possible CAA-ri, and 1 of 16 (6%) met the criteria for probable CAA-ri. These findings yielded a sensitivity and specificity of 82% and 97%, respectively, for the probable criteria and a sensitivity and specificity of 82% and 68%, respectively, for the possible criteria. Conclusions and Relevance Our data suggest that a reliable diagnosis of CAA-ri can be reached from basic clinical and magnetic resonance imaging information alone, with good sensitivity and excellent specificity.
- Published
- 2016
48. Endovascular therapy in patients with a large ischemic volume at presentation: An aggregate patient-level analysis.
- Author
-
Kerleroux B, Hak JF, Lapergue B, Bricout N, Zhu F, Inoue M, Janot K, Dargazanli C, Kaesmacher J, Rouchaud A, Forestier G, Gortais H, Benzakoun J, Yoshimoto T, Consoli A, Ben Hassen W, Henon H, Naggara O, and Boulouis G
- Subjects
- Humans, Female, Male, Aged, Middle Aged, Retrospective Studies, Treatment Outcome, Aged, 80 and over, Thrombectomy methods, Brain Ischemia surgery, Cohort Studies, Endovascular Procedures methods, Ischemic Stroke surgery, Ischemic Stroke diagnostic imaging, Ischemic Stroke therapy
- Abstract
Introduction: Recently, four randomized controlled trials (RCTs) have demonstrated the benefits of mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) caused by anterior large vessel occlusion (LVO) and a large ischemic core at baseline (LIC). The purpose of this study was to investigate the features influencing the clinical outcome and the benefits of mechanical thrombectomy in this subgroup., Methods: We conducted a multicenter retrospective aggregate cohort study of patients with AIS-LVO and a LIC, assessed with quantitative core volume measures, treated with MT between 2012 and 2019. The data were queried through four registries, including patients with core volumes ≥50cc. Multivariable logistic regression models were employed to determine factors independently associated with clinical outcomes in patients with successful recanalization (modified-Thrombolysis-in-Cerebral-Infarction-score, mTICI=2b-3) and unsuccessful recanalization group (mTICI=0-2a). The primary endpoint was a favorable functional outcome at day-90, defined as a modified Rankin scale (mRS) of 0-3, accounting for the inherent severity of AIS with baseline LIC. Secondary outcomes included functional independence (mRS 0-2) at day-90, mortality, and symptomatic Intracranial Hemorrhage (sICH)., Results: A total of 460 patients were included (mean age 66±14.2 years; 39.6 % females). The mean baseline NIHSS was 20±5.2, and the core volume was 103.2±54.6 ml. Overall, 39.8 % (183/460) of patients achieved a favorable outcome at day-90 (mRS 0-3). Successful recanalization was significantly associated with a more frequent favorable outcome (aOR, 4.79; 95 %CI, 2.73-8.38; P<0.01) and functional independence (P<0.01). This benefit remained significant in older patients and in patients with cores above 100cc. At 90 days, 147/460 patients (32 %) were deceased, with successful recanalization significantly associated with less frequent mortality (OR, 0.34; 95 %CI, 0.22-0.53; P<0.01). The rate of sICH was 17.4 % and did not differ significantly between groups., Conclusions: In this large, pooled-cohort study of AIS-LVO patients with infarct cores over 50cc at baseline, we demonstrated that successful recanalization was associated with a better functional outcome, lower mortality, and similar rates of symptomatic intracranial hemorrhage for a wide spectrum of patients., Competing Interests: Declaration of Competing Interest The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
49. The impact of general anesthesia versus non-general anesthesia on thrombectomy outcomes by occlusion location: insights from the ETIS registry.
- Author
-
Anadani M, Gory B, Olivot JM, Bourcier R, Consoli A, Boulouis G, Janot K, Pop R, Desilles JP, Hamoud L, Mazighi M, Lapergue B, Marnat G, and Finitsis S
- Abstract
Objective: Identifying the optimal anesthetic technique for mechanical thrombectomy (MT) remains an unresolved issue. Prior research has not considered the influence of occlusion site when comparing general anesthesia (GA) with non-GA. This study evaluates the differential impacts of the anesthetic technique (GA vs non-GA) on outcomes according to the location of occlusion., Methods: This is a retrospective analysis of the ETIS (Endovascular Treatment in Ischemic Stroke) registry. Patients with anterior circulation large-vessel occlusion treated with MT were included. Patients were divided into groups according to the location of occlusion. Inverse propensity score weighting analysis was used., Results: Among 2783 patients included in the propensity score analysis, 669 (24%) received GA. In the total cohort, GA was not associated with favorable outcome, excellent outcome, successful reperfusion, or complete reperfusion. GA was associated with higher odds of parenchymal hemorrhage (OR 1.42, 95% 1.05-1.92) but not symptomatic intracranial hemorrhage. GA was associated with Alberta Stroke Program Early CT Score progression (OR 1.36, 95% CI 1.11-1.68). In the internal carotid artery occlusion group, GA was associated with higher odds of mortality (OR 1.94, 95% CI 1.15-3.27). In the M1 group, GA was associated with lower odds of complications (OR 0.41, 95% CI 0.19-0.92). In the M2 group, GA was associated with successful reperfusion (OR 2.79, 95% CI 1.02-7.64). In addition, the complication rate was lower with GA (2.7% vs 7%), although the association was not significant in adjusted analysis., Conclusions: While GA and non-GA techniques did not differ significantly in functional outcomes, the influence of GA on angiographic and procedural safety outcomes was location dependent, underscoring the importance of a tailored anesthesia technique in MT procedures.
- Published
- 2024
- Full Text
- View/download PDF
50. Cerebral Amyloid Angiopathy-Related Inflammation and Biopsy-Positive Primary Angiitis of the CNS: A Comparative Study.
- Author
-
Grangeon L, Boulouis G, Capron J, Bala F, Renard D, Raposo N, Ozkul-Wermester O, Triquenot-Bagan A, Ayrignac X, Wallon D, Gerardin E, Kerschen P, Sablot D, Formaglio M, Pico F, Turc G, Verny M, Humbertjean L, Gaudron M, Vannier S, Dequatre N, Guillon B, Isabel C, Arquizan C, Detante O, Godard S, Casolla B, Levraut M, Gollion C, Gerfaud-Valentin M, Kremer L, Daelman L, Lambert N, Lanthier S, Poppe A, Régent A, Weisenburger-Lile D, Verdure P, Quesney G, Vautier M, Wacongne A, Thouvenot E, Pariente J, Coulette S, Labauge PM, Olivier N, Allou T, Zephir H, Néel A, Bresch S, Terrier B, Martinaud O, Schneckenburger R, Papo T, Comarmond-Ortoli C, Jouvent E, Subréville M, Poncet-Megemont L, Khatib MA, Lun F, Henry C, Magnin E, Thomas Q, Graber M, Boukriche Y, Blanchet-Fourcade G, Ratiu D, Pagnoux C, Touzé E, de Boysson H, Alamowitch S, and Nehme A
- Subjects
- Humans, Female, Male, Aged, Middle Aged, Retrospective Studies, Biopsy, Magnetic Resonance Imaging, Aged, 80 and over, Brain pathology, Brain diagnostic imaging, Adult, Recurrence, Cerebral Amyloid Angiopathy diagnostic imaging, Cerebral Amyloid Angiopathy pathology, Cerebral Amyloid Angiopathy complications, Vasculitis, Central Nervous System diagnostic imaging, Vasculitis, Central Nervous System pathology
- Abstract
Background and Objectives: Cerebral amyloid angiopathy-related inflammation (CAA-RI) and biopsy-positive primary angiitis of the CNS (BP-PACNS) have overlapping clinicoradiologic presentations. It is unknown whether clinical and radiologic features can differentiate CAA-RI from BP-PACNS and whether both diseases have different relapse rates. The objectives of this study were to compare clinicoradiologic presentations and relapse rates in patients with CAA-RI vs BP-PACNS., Methods: Patients with CAA-RI and BP-PACNS were enrolled from 2 retrospective multicenter cohorts. Patients with CAA-RI were biopsy-positive or met probable clinicoradiologic criteria. Patients with BP-PACNS had histopathologic confirmation of CNS angiitis, with no secondary etiology. A neuroradiologist read brain MRIs, blinded to the diagnosis of CAA-RI or BP-PACNS. Clinicoradiologic features were compared using univariable logistic regression models. Relapse rates were compared using a univariable Fine-Gray subdistribution hazard model, with death as a competing risk., Results: This study enrolled 104 patients with CAA-RI (mean age 73 years, 48% female sex) and 52 patients with BP-PACNS (mean age 45 years, 48% female sex). Patients with CAA-RI more often had white matter hyperintense lesions meeting the probable CAA-RI criteria (93% vs 51%, p < 0.001), acute subarachnoid hemorrhage (15% vs 2%, p = 0.02), cortical superficial siderosis (27% vs 4%, p < 0.001), ≥1 lobar microbleed (94% vs 26%, p < 0.001), past intracerebral hemorrhage (17% vs 4%, p = 0.04), ≥21 visible centrum semiovale perivascular spaces (34% vs 4%, p < 0.01), and leptomeningeal enhancement (70% vs 27%, p < 0.001). Patients with BP-PACNS more often had headaches (56% vs 31%, p < 0.01), motor deficits (56% vs 36%, p = 0.02), and nonischemic parenchymal gadolinium enhancement (82% vs 16%, p < 0.001). The prevalence of acute ischemic lesions was 18% in CAA-RI and 22% in BP-PACNS ( p = 0.57). The features with the highest specificity for CAA-RI were acute subarachnoid hemorrhage (98%), cortical superficial siderosis (96%), past intracerebral hemorrhage (96%), and ≥21 visible centrum semiovale perivascular spaces (96%). The probable CAA-RI criteria had a 71% sensitivity (95% CI 44%-90%) and 91% specificity (95% CI 79%-98%) in differentiating biopsy-positive CAA-RI from BP-PACNS. The rate of relapse in the first 2 years after remission was lower in CAA-RI than in BP-PACNS (hazard ratio 0.46, 95% CI 0.22-0.96, p = 0.04)., Conclusion: Clinicoradiologic features differed between patients with CAA-RI and those with BP-PACNS. Specific markers for CAA-RI were hemorrhagic signs of subarachnoid involvement, past intracerebral hemorrhage, ≥21 visible centrum semiovale perivascular spaces, and the probable CAA-RI criteria. A biopsy remains necessary for diagnosis in some cases of CAA-RI. The rate of relapse in the first 2 years after disease remission was lower in CAA-RI than in BP-PACNS.
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.