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During the Palaeocene-Eocene Thermal Maximum (PETM) about 56 million years ago, thousands of petagrams of carbon were released into the atmosphere and ocean in just a few thousand years, followed by gradual sequestration over approximately 200,000 years. If silicate weathering is one of the key negative feedbacks that removed this carbon, a period of seawater calcium carbonate saturation greater than pre-event levels would be expected during the event's recovery phase. In marine sediments, this should be recorded as a temporary deepening of the depth below which no calcite is preserved-the calcite compensation depth (CCD). Previous and new sedimentary records from sites that were above the pre-PETM CCD show enhanced carbonate accumulation following the PETM. A new record from an abyssal site in the North Atlantic that lay below the pre-PETM CCD shows a period of carbonate preservation beginning about 70,000 years after the onset of the PETM, providing the first direct evidence for an over-deepening of the CCD. This record confirms an overshoot in ocean carbonate saturation during the PETM recovery. Simulations with two earth system models support scenarios for the PETM that involve a large initial carbon release followed by prolonged low-level emissions, consistent with the timing of CCD deepening in our record. Our findings indicate that sequestration of these carbon emissions was most likely the result of both globally enhanced calcite burial above the CCD and, at least in the North Atlantic, an over-deepening of the CCD.

A chemostratigraphic study (δ13C and δ18O) of the Late Cenomanian and Turonian chalk succession from the “Craie 701” Poigny borehole (near Provins in the Paris Basin, France) provides new high-resolution stable carbon and oxygen isotope data. Correlation of the bentonite horizons and the isotopic trends from Poigny with its English Chalk equivalent allows the development of a precise stratigraphic framework. δ13C and δ18O variations are synchronous and widespread throughout the European epicontinental seas and Tethyan Ocean. In the Poigny borehole, the Oceanic Anoxic Event 2 (OAE 2) is marked by a large and brief positive excursion of carbon isotopes (a carbon isotope excursions: CIE of 3‰ amplitude) without any apparent anoxia in the Late Cenomanian Chalk. Comparisons between different key sections on a North-South transect from the Anglo-Paris Basin to the Umbria-Marche Basin (Gubbio Section, Italy) and the Vocontian Basin (South-East France), suggests that the OAE 2 is linked to an increase in marine organic matter production, modulated by a regional effect on the organic carbon burial rate. Thus, the large positive carbon isotope increase spanning the Middle Cenomanian through to the Middle Turonian, including the salient CIE associated with the OAE 2, reflects a global scale increase in marine productivity that would be concomitant with a major long-term sea level rise. The stratigraphic position of the Turonian-Coniacian boundary can also be better defined by this isotopic study. A comparison of δ18O data between the Anglo-Paris Basin and Tethyan Basin shows high-amplitude, long-term synchronous variations reflecting primary paleo-environmental changes which are independent of local facies, sediment thickness and diagenesis. In particular, a negative shift (−1‰ of amplitude) reflects a warmer climate regime, marking the onset of OAE 2. Two colder phases (+1‰ amplitude each) occurred in the Early Turonian and the beginning of the Late Turonian.

Astronomical forcing of Earth's climate is embedded in the rhythms of stratigraphic records, most famously as short-period (10 4 -10 5 year) Milankovitch cycles. Astronomical grand cycles with periods of millions of years also modulate climate variability but have been detected in relatively few proxy records. Here, we apply spectral analysis to a dataset of Cenozoic deep-sea hiatuses to reveal a ~2.4 Myr eccentricity signal, disrupted by episodes of major tectonic forcing. We propose that maxima in the hiatus cycles correspond to orbitally-forced intensification of deep-water circulation and erosive bottom current activity, linked to eccentricity maxima and peaks in insolation and seasonality. A prominent episode of cyclicity disturbance coincides with the Paleocene-Eocene Thermal Maximum (PETM) at ~56 Myr ago, and correlates with a chaotic orbital transition in the Solar System evident in several astronomical solutions. This hints at a potential intriguing coupling between the PETM and Solar System chaos., (© 2024. The Author(s).)

The fossil record reveals that biotic diversity has fluctuated quasi-cyclically through geological time. However, the causal mechanisms of biotic diversity cycles remain unexplained. Here, we highlight a common, correlatable 36 ± 1 Myr (million years) cycle in the diversity of marine genera as well as in tectonic, sea-level, and macrostratigraphic data over the past 250 Myr of Earth history. The prominence of the 36 ± 1 Myr cycle in tectonic data favors a common-cause mechanism, wherein geological forcing mechanisms drive patterns in both biological diversity and the preserved rock record. In particular, our results suggest that a 36 ± 1 Myr tectono-eustatically driven sea-level cycle may originate from the interaction between the convecting mantle and subducting slabs, thereby pacing mantle-lithospheric deep-water recycling. The 36 ± 1 Myr tectono-eustatic driver of biodiversity is likely related to cyclic continental inundations, with expanding and contracting ecological niches on shelves and in epeiric seas.

Earth's past climate exhibits short-term (1500-year) pronounced fluctuations during the last glacial period, called Dansgaard-Oeschger (DO) glacial events, which have never been detected in pre-Quaternary times. The record of DO equivalent climate variability in Mesozoic strata can provide constraints on understanding these events. Here we highlight a prominent 1500-year cyclicity in a Jurassic (~ 155 Ma) ice-free sedimentary record from the Tethyan Basin. This Jurassic 1500-year cyclicity is encoded in high-resolution magnetic susceptibility (MS) proxy data reflecting detrital variations, and expressed as marl-limestone couplets. Additionally, MS data detect the modulation of these DO-scale couplets by supercouplet sets, reflecting the precession and its harmonics. We suggest that this Jurassic DO-like cyclicity may originate from paleo-monsoon-like system, analogous to the record of DO events in the Pleistocene East Asian monsoon archives. Paleogeographic reconstructions and atmosphere-ocean simulations further support the potential existence of strong, ancient monsoon circulations in the Tethyan Basin during the Jurassic., (© 2022. The Author(s).)

The present study aimed to evaluate the performance effect of aqueous extract of Rosmarinus officinalis (AERO) against the kidney toxicity induced by CCl 4 in mice. The results showed that the renal damage induced by CCl 4 was associated with a rise in oxidative stress monitored by a significant increase of TBARS and PCO levels (+89% and +136% respectively, p  < .001) and a significant decrease of GSH level (-68%, p  < .001) and antioxidants enzymes such as SOD, CAT, and GPX activities (-41.7%, -47.8%, and -50.5%; p  < .001, respectively). Also, the nephropathology parameters including creatinine, BUN, and urea (+68.9%, +47%, +48·6% respectively, p  < .05) were remarkably increased. These findings were substantiated by histological study. Pretreatment with Rosemary extract significantly attenuated the CCl 4 related toxic effects via more than one mechanism such as the inhibition of lipid peroxidation, the stimulation of the synthesis of cellular antioxidants, the decrease of the biomarker kidney and the correction of the kidney structure. We can conclude that the Rosemary is efficient in the prevention of kidney function against CCl 4 toxicity.

Geological sediment archives document a rich periodic series of astronomically driven climate, but record also abrupt, severe climatic changes called events, the multi-Myr boundary conditions of which have generally been ascribed to acyclic processes from Earth's interior dynamics. These events have rarely been considered together within extended time series for potential correlation with long-term (multi-million year, Myr) cycling. Here I show a coupling between events and multi-Myr cycles in a temperature and ice-volume climatic proxy of the geological past 115 Myr. I use Cenozoic through middle Cretaceous climatic variations, as recorded in benthic foraminifera δ 18 O, to highlight prominent ~9 and ~36 Myr cyclicities. These cyclicities were previously attributed either to astronomical or tectonic variations. In particular, I point out that most of the well-known events during the past 115 Myr geological interval occur during extremes in the ~9 and ~36 Myr cycling. One exception is the early Cenozoic hyperthermal events including the salient Paleocene-Eocene Thermal Maximum (~56 Ma), which do not match extremes in long-period cyclicities, but to inflection point of these cycles. Specific focus on climatic events, as inferred from δ 18 O proxy, suggest that some "events", marked by gradual trends within the ~9 and ~36 Myr cycle extremes, would principally be paced by long-term cycling, while "events", recorded as abrupt δ 18 O changes nearby cycle extremes, would be rather induced by acyclic processes. The connection between cyclic and acyclic processes, as triggers or feedbacks, is very likely. Such link between cycling and events in Earth's past climate provides insight into celestial dynamics governing perturbations in Earth's surface systems, but also the potential connection between external and Earth's interior processes.

Fermented milk is known to possess potent antioxidant activity. The present study was undertaken to assess the preventive effect of fermented camel milk (FCM) prepared using lactococcus lactis subsp. cremoris against CCl4 induced kidney damage in mice. Nephrotoxicity was induced in mice by a single dose of CCl4 (10 ml/kg 0·3% olive oil, ip). Female mice were pretreated daily with FCM for 15 d. Renal damage was associated with an increase in oxidative stress parameters (lipid peroxidation, protein carbonyl and changes in antioxidant enzyme activities and non-enzymatic antioxidant) and nephropathology markers.The renal injury induced by CCl4 was confirmed by the histological study of the CCl4-intoxicated mice. Pretreatment with FCM significantly prevented renal dysfunction by reducing oxidative stress, while mice recovered normal kidney histology. Moreover, FCM prevented toxicity biomarker changes by reducing creatinine, urea, uric acid, lactate dehydrogenase (LDH) and electrolytes levels in plasma. These data indicate that FCM is efficient in inhibiting oxidative stress induced by CCl4, and suggests that the administration of this milk may be helpful in the prevention of kidney damage.

This study investigated the effect of bioglass (melting)-polyvinyl alcohol (BG (M)-PVA) and bioglass (melting)-polyvinyl alcohol-20 %ciprofloxacin (BG(M)-PVA-20Cip) in improving antioxidant activity and regenerating bone capacity. These composites were implanted in femoral condyles of ovariectomized Wistar rats and compared to that of controls groups. After the different period of implantation (15, 30, 60 and 90 days), the treatment of ovariectomized rats with BG(M)-PVA-20Cip showed a significantly higher malondialdehyde concentration when compared to that of BG(M)-PVA group. The superoxide dismutase, glutathione peroxidase and catalase in BG(M)-PVA-20Cip group showed significantly lower activities when compared to those in BG(M)-PVA group. So, BG(M)-PVA is more tolerated by organism than BG(M)-PVA-20Cip. Moreover, the alkaline phosphatase and acid phosphatase activities showed an excellent osteoinductive property of BG (M)-PVA. This property decreased with the presence of ciprofloxacin which is confirmed by histopathological analysis. Several physicochemical techniques showed a rapid reduction in Si and Na in one hand and an accelerator rise in Ca and P ions concentrations in other hand in BG(M)-PVA than in the BG(M)-PVA-20Cip. Therefore, the incorporation of ciprofloxacin in BG(M)-PVA is characterized by a prooxidant effect in oxidant-antioxidant balance at the beginning of treatment and a retard effect of formation of apatitic phase.

Aims: This study aimed to investigate the potential effects of a synthetic apatite (carbonated hydroxyapatite) on the detoxification of a group of male "Wistar" rats exposed to nickel chloride., Methods: Toxicity was evaluated by rats' bioassay of nickel chloride. Wistar rats received this metal daily by gavage for seven days (4 mg/ml nickel chloride/200 g body weight, BW). To detoxify this organism, a subcutaneous implantation of the apatite is made., Results: The results revealed that exposure to nickel induced oxidative stress, disorders in the balances of ferric phosphocalcic, renal failures, liver toxicity and significant increase in nickel rates in the bones of intoxicated rats. The application of the carbonated hydroxyapatite presented in this study restored those disorders back to normal. The synthetic apatite protected the rats against the toxic effects of nickel by lowering the levels of lipid peroxidation markers and improving the activities of defense enzymes. It also amended ferric and phosphocalcic equilibriums, protected liver and kidney functions and reduced the nickel rate in the bones of the rats. Overall, the results provided strong support for the protective role of carbonated hydroxyapatite in the detoxification of rats exposed to nickel. Those beneficial effects were further confirmed by physico-chemical characterization (X-ray diffraction and infrared spectroscopy), which revealed its property of anionic and cationic substitution, thus supporting its promising candidacy for future biomedical application., Conclusion: The hydroxyapatite is an effective biomaterial to solve health problems, particularly detoxification against metals (nickel).