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Summary: The present study reports a methodology for the synthesis of symmetrical and unsymmetrical thiourea derivatives 1-9, which have been prepared in good overall yields from condensation reactions between phenylisothiocyanate and different primary amines. The structures of all products were confirmed by the spectroscopic analysis (UV, IR, and NMR). T hese derivatives were tested for anticoagulant activity using PT and APTT reagents, and those reagents are considered also a controller, the results showed that the theN-aryl thiourea derivatives have very high anticoagulant activity. Theoretical calculations based on DFT/B3LYP method have been performed in order to get insights into the molecular geometry and chemical reactivity of the studied compounds. [ABSTRACT FROM AUTHOR]

In this study, the rachis extracts of eight date palm Phoenix dactylifera L. cultivars were analysed by phytochemical screening and bioautography on Fusarium oxysporum f. sp. albedinis (Foa). The choice of cultivars was based on their reaction to Foa (resistant, tolerant and sensitive). Phytochemical screening was realised for flavonoids, tannins, alkaloids and coumarins. Antifungal effects were mostly represented by dichloromethanic extracts (seven out of nine inhibition zones). The best results were represented by the dichloromethanic extract of the cultivar ‘Bent-Cherk’ rachis (6.50 ± 1.41 mm) and the ethyl acetate extract of the cultivar ‘Rotbi’ rachis (6.00 ± 1.41 mm). The date palm cultivars presented some similarities concerning phytochemical screening results related to their resistance or sensibility to Foa. From the correlation between phytochemical screening and bioautography, it was observed that the majority of bioactive compounds against Foa seem to be polyphenols. Thus, the natural defence mechanism in vivo against Foa is probably related to the action of polyphenols. The difference between resistant, tolerant and sensitive cultivars is related to their mechanism of action. [ABSTRACT FROM PUBLISHER]