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1. Access to Care and Therapy for Kawasaki Disease in the Arab Countries: A Kawasaki Disease Arab Initiative (Kawarabi) Multicenter Survey

Author

Alzyoud, Raed, El-Kholy, Nermeen, Arab, Yousra, Choueiter, Nadine, Harahsheh, Ashraf S., Aselan, Adnan Salem, Kotby, Alyaa, Bouaziz, Asma, Salih, Aso F., Abushhaiwia, Awatif, Alahmadi, Fahad, Agha, Hala M., Elmarsafawy, Hala M., Alrabte, Hanifa, Al-Saloos, Hesham, Boudiaf, Houda, Hijazi, Issa, Bouayed, Kenza, Al Senaidi, Khalfan Salim, Boughammoura, Lamia, Jalal, Maryam, Ladj, Mohamed S., Abu-Shukair, Mohammed E., ElGanzoury, Mona M., Hammadouche, Nacera, Elsamman, Nora, Mouawad, Pierre, Boukari, Rachida, Benalikhoudja, Nassiba, Jdour, Salima, Abu Al-Saoud, Sima Y., Touri, Soued Nabila, Kammoun, Thouraya, Fitouri, Zohra, and Dahdah, Nagib

Published
2023
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2. Algerian Registry for Inborn Errors of Immunity in Children: Report of 887 Children (1985–2021)

Author

Yagoubi, Abdelghani, Tahiat, Azzeddine, Touri, Nabila Souad, Ladj, Mohamed Samir, Drali, Ouardia, Belaid, Brahim, Mohand-Oussaid, Ayda, Dehimi, Abdelhak, Belbouab, Reda, Ferhani, Yacine, Melzi, Souhila, Guedouar, Assia, Hakem, Saliha, Khemici, Ouardia, Inouri, Yacine, Meddour, Yanis, Dib, Saadeddine, Mansouri, Zohra, Iddir, Samir, Boufersaoui, Abderrahmane, Boudiaf, Houda, Bouhdjila, Abderrachid, Ibsaine, Ouardia, Maouche, Hachemi, Dahlouk, Djazia, Mekki, Azzedine, Bioud, Belkacem, Bouzerar, Zair, Zeroual, Zoulikha, Benhassine, Fadila, Bekkat-Berkani, Dahila, Naamoune, Soumeya, Salah, Samir Sofiane, Chaib, Samia, Attal, Nabila, Bensaadi, Nadia, Bouchair, Nadira, Cherif, Nacira, Kedji, Leila, Bendeddouche, Salih, Atif, Mohamed Lamine, Djenouhat, Kamel, Kechout, Nadia, Djidjik, Reda, Benhalla, Keltoum Nafissa, Smati, Leila, and Boukari, Rachida

Published
2022
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3. Kawasaki Disease Arab Initiative [Kawarabi]: Establishment and Results of a Multicenter Survey

Author

Arab, Yousra, Choueiter, Nadine, Dahdah, Nagib, El-Kholy, Nermeen, Abu Al-Saoud, Sima Y., Abu-Shukair, Mohammed E., Agha, Hala M., Al-Saloos, Hesham, Al Senaidi, Khalfan Salim, Alzyoud, Raed, Bouaziz, Asma, Boukari, Rachida, El Ganzoury, Mona M., Elmarsafawy, Hala M., ELrugige, Najat, Fitouri, Zohra, Ladj, Mohamed S., Mouawad, Pierre, Salih, Aso F., Rojas, Rocio G., and Harahsheh, Ashraf S.

Published
2022
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4. Clinical, immunological, molecular and therapeutic findings in monogenic immune dysregulation diseases: Middle East and North Africa registry

Author

Rasouli, Seyed Erfan, Esmaeili, Marzie, Yazdani, Reza, Delavari, Samaneh, Tavakol, Marzieh, Sadri, Homa, Karimi, Abdollah, Shiari, Reza, Alavi, Samin, Babaie, Delara, Eshghi, Peyman, Armin, Shahnaz, Vosughimotlagh, Ahmad, Eltan, Sevgi Bilgic, Babayeva, Royala, Sefer, Asena Pinar, Kolukisa, Burcu, Gungoren, Ezgi Yalcin, Altunbas, Melek Yorgun, Mammadova, Vafa, Jamee, Mahnaz, Azizi, Gholamreza, Baris, Safa, Karakoc-Aydiner, Elif, Ozen, Ahmet, Kiliç, Sara Ş., Kose, Hulya, Chavoshzadeh, Zahra, Mahdaviani, Seyed Alireza, Momen, Tooba, Shamsian, Bibi Shahin, Fallahi, Mazdak, Sharafian, Samin, Gülez, Nesrin, Aygun, Ayşe, Karaca, Neslihan Edeer, Kutukculer, Necil, Al Sukait, Nashat, Al Farsi, Tariq, Al-Tamemi, Salem, Khalifa, Nisreen, Shereen, Reda, El-Ghoneimy, Dalia, El-Owaidy, Rasha, Radwan, Nesrine, Alzyoud, Raed, Barbouche, Mohamed-Ridha, Ben-Mustapha, Imen, Mekki, Najla, Rais, Afef, Boukari, Rachida, Belbouab, Reda, Djenouhat, Kamel, Tahiat, Azzeddine, Touri, Souad, Elghazali, Gehad, Al-Hammadi, Suleiman, Shendi, Hiba Mohammed, Alkuwaiti, Amna, Belaid, Brahim, Djidjik, Reda, Artac, Hasibe, Adeli, Mehdi, Sobh, Ali, Elnagdy, Marwa H., Bahgat, Sara A., Nasrullayeva, Gulnara, Chou, Janet, Rezaei, Nima, Al-Herz, Waleed, Geha, Raif S., and Abolhassani, Hassan

Published
2022
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5. The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity

Author

Baris, Safa, Abolhassani, Hassan, Massaad, Michel J., Al-Nesf, Maryam, Chavoshzadeh, Zahra, Keles, Sevgi, Reisli, Ismail, Tahiat, Azzeddine, Shendi, Hiba Mohammad, Elaziz, Dalia Abd, Belaid, Brahim, Al Dhaheri, Fatima, Haskologlu, Sule, Dogu, Figen, Ben-Mustapha, Imen, Sobh, Ali, Galal, Nermeen, Meshaal, Safa, Elhawary, Rabab, El-marsafy, Aisha, Alroqi, Fayhan J., Al-Saud, Bandar, Al-Ahmad, Mona, Al Farsi, Tariq, AL Sukaiti, Nashat, Al-Tamemi, Salem, Mehawej, Cybel, Dbaibo, Ghassan, ElGhazali, Gehad, Kilic, Sara Sebnem, Genel, Ferah, Kiykim, Ayca, Musabak, Ugur, Artac, Hasibe, Guner, Sukru Nail, Boukari, Rachida, Djidjik, Reda, Kechout, Nadia, Cagdas, Deniz, El-Sayed, Zeinab Awad, Karakoc-Aydiner, Elif, Alzyoud, Raed, Barbouche, Mohamed Ridha, Adeli, Mehdi, Wakim, Rima Hanna, Reda, Shereen M., Ikinciogullari, Aydan, Ozen, Ahmet, Bousfiha, Aziz, Al-Mousa, Hamoud, Rezaei, Nima, Al-Herz, Waleed, and Geha, Raif S.

Published
2022
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6. Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases

Author

Li, Yue, Führer, Marita, Bahrami, Ehsan, Socha, Piotr, Klaudel-Dreszler, Maja, Bouzidi, Amira, Liu, Yanshan, Lehle, Anna S., Magg, Thomas, Hollizeck, Sebastian, Rohlfs, Meino, Conca, Raffaele, Field, Michael, Warner, Neil, Mordechai, Slae, Shteyer, Eyal, Turner, Dan, Boukari, Rachida, Belbouab, Reda, Walz, Christoph, Gaidt, Moritz M., Hornung, Veit, Baumann, Bernd, Pannicke, Ulrich, Idrissi, Eman Al, Alghamdi, Hamza Ali, Sepulveda, Fernando E., Gil, Marine, de Saint Basile, Geneviève, Hönig, Manfred, Koletzko, Sibylle, Muise, Aleixo M., Snapper, Scott B., Schwarz, Klaus, Klein, Christoph, and Kotlarz, Daniel

Published
2019

8. X-linked agammaglobulinemia (XLA): Phenotype, diagnosis, and therapeutic challenges around the world

Author

El-Sayed, Zeinab A., Abramova, Irina, Aldave, Juan Carlos, Al-Herz, Waleed, Bezrodnik, Liliana, Boukari, Rachida, Bousfiha, Ahmed Aziz, Cancrini, Caterina, Condino-Neto, Antonio, Dbaibo, Ghassan, Derfalvi, Beata, Dogu, Figen, Edgar, J.David M., Eley, Brian, El-Owaidy, Rasha Hasan, Espinosa-Padilla, Sara Elva, Galal, Nermeen, Haerynck, Filomeen, Hanna-Wakim, Rima, Hossny, Elham, Ikinciogullari, Aydan, Kamal, Ebtihal, Kanegane, Hirokazu, Kechout, Nadia, Lau, Yu Lung, Morio, Tomohiro, Moschese, Viviana, Neves, Joao Farela, Ouederni, Monia, Paganelli, Roberto, Paris, Kenneth, Pignata, Claudio, Plebani, Alessandro, Qamar, Farah Naz, Qureshi, Sonia, Radhakrishnan, Nita, Rezaei, Nima, Rosario, Nelson, Routes, John, Sanchez, Berta, Sediva, Anna, Seppanen, Mikko RJ., Serrano, Edith Gonzalez, Shcherbina, Anna, Singh, Surjit, Siniah, Sangeetha, Spadaro, Guiseppe, Tang, Mimi, Vinet, Ana Maria, Volokha, Alla, and Sullivan, Kathleen E.

Published
2019
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9. Access to Care and Therapy for Kawasaki Disease in the Arab Countries: A Kawasaki Disease Arab Initiative (Kawarabi) Multicenter Survey

Author

Alzyoud, Raed, primary, El-Kholy, Nermeen, additional, Arab, Yousra, additional, Choueiter, Nadine, additional, Harahsheh, Ashraf S., additional, Aselan, Adnan Salem, additional, Kotby, Alyaa, additional, Bouaziz, Asma, additional, Salih, Aso F., additional, Abushhaiwia, Awatif, additional, Alahmadi, Fahad, additional, Agha, Hala M., additional, Elmarsafawy, Hala M., additional, Alrabte, Hanifa, additional, Al-Saloos, Hesham, additional, Boudiaf, Houda, additional, Hijazi, Issa, additional, Bouayed, Kenza, additional, Senaidi, Khalfan Salim Al, additional, Boughammoura, Lamia, additional, Jalal, Maryam, additional, Ladj, Mohamed S., additional, Abu-Shukair, Mohammed E., additional, Ganzoury, Mona M. El, additional, Hammadouche, Nacera, additional, Elsamman, Nora, additional, Mouawad, Pierre, additional, Boukari, Rachida, additional, Benalikhoudja, Nassiba, additional, Jd, Salima, additional, Al-Saoud, Sima Y. Abu, additional, Touri, Soued Nabila, additional, Kammoun, Thouraya, additional, Fitouri, Zohra, additional, and Dahdah, Nagib, additional

Published
2023
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10. The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity

Author

Baris, Safa, primary, Abolhassani, Hassan, additional, Massaad, Michel J., additional, Al-Nesf, Maryam, additional, Chavoshzadeh, Zahra, additional, Keles, Sevgi, additional, Reisli, Ismail, additional, Tahiat, Azzeddine, additional, Shendi, Hiba Mohammad, additional, Elaziz, Dalia Abd, additional, Belaid, Brahim, additional, Al Dhaheri, Fatima, additional, Haskologlu, Sule, additional, Dogu, Figen, additional, Ben-Mustapha, Imen, additional, Sobh, Ali, additional, Galal, Nermeen, additional, Meshaal, Safa, additional, Elhawary, Rabab, additional, El-marsafy, Aisha, additional, Alroqi, Fayhan J., additional, Al-Saud, Bandar, additional, Al-Ahmad, Mona, additional, Al Farsi, Tariq, additional, AL Sukaiti, Nashat, additional, Al-Tamemi, Salem, additional, Mehawej, Cybel, additional, Dbaibo, Ghassan, additional, ElGhazali, Gehad, additional, Kilic, Sara Sebnem, additional, Genel, Ferah, additional, Kiykim, Ayca, additional, Musabak, Ugur, additional, Artac, Hasibe, additional, Guner, Sukru Nail, additional, Boukari, Rachida, additional, Djidjik, Reda, additional, Kechout, Nadia, additional, Cagdas, Deniz, additional, El-Sayed, Zeinab Awad, additional, Karakoc-Aydiner, Elif, additional, Alzyoud, Raed, additional, Barbouche, Mohamed Ridha, additional, Adeli, Mehdi, additional, Wakim, Rima Hanna, additional, Reda, Shereen M., additional, Ikinciogullari, Aydan, additional, Ozen, Ahmet, additional, Bousfiha, Aziz, additional, Al-Mousa, Hamoud, additional, Rezaei, Nima, additional, Al-Herz, Waleed, additional, and Geha, Raif S., additional

Published
2023
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11. Clinical, immunological, molecular and therapeutic findings in monogenic immune dysregulation diseases: Middle East and North Africa registry

Author

Jamee, Mahnaz, primary, Azizi, Gholamreza, additional, Baris, Safa, additional, Karakoc-Aydiner, Elif, additional, Ozen, Ahmet, additional, Kiliç, Sara Ş., additional, Kose, Hulya, additional, Chavoshzadeh, Zahra, additional, Mahdaviani, Seyed Alireza, additional, Momen, Tooba, additional, Shamsian, Bibi Shahin, additional, Fallahi, Mazdak, additional, Sharafian, Samin, additional, Gülez, Nesrin, additional, Aygun, Ayşe, additional, Karaca, Neslihan Edeer, additional, Kutukculer, Necil, additional, Al Sukait, Nashat, additional, Al Farsi, Tariq, additional, Al-Tamemi, Salem, additional, Khalifa, Nisreen, additional, Shereen, Reda, additional, El-Ghoneimy, Dalia, additional, El-Owaidy, Rasha, additional, Radwan, Nesrine, additional, Alzyoud, Raed, additional, Barbouche, Mohamed-Ridha, additional, Ben-Mustapha, Imen, additional, Mekki, Najla, additional, Rais, Afef, additional, Boukari, Rachida, additional, Belbouab, Reda, additional, Djenouhat, Kamel, additional, Tahiat, Azzeddine, additional, Touri, Souad, additional, Elghazali, Gehad, additional, Al-Hammadi, Suleiman, additional, Shendi, Hiba Mohammed, additional, Alkuwaiti, Amna, additional, Belaid, Brahim, additional, Djidjik, Reda, additional, Artac, Hasibe, additional, Adeli, Mehdi, additional, Sobh, Ali, additional, Elnagdy, Marwa H., additional, Bahgat, Sara A., additional, Nasrullayeva, Gulnara, additional, Chou, Janet, additional, Rezaei, Nima, additional, Al-Herz, Waleed, additional, Geha, Raif S., additional, and Abolhassani, Hassan, additional

Published
2022
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13. X-Linked Agammagobulinemia in a Large Series of North African Patients: Frequency, Clinical Features and Novel BTK Mutations

Author

Aadam, Zahra, Kechout, Nadia, Barakat, Abdelhamid, Chan, Koon-Wing, Ben-Ali, Meriem, Ben-Mustapha, Imen, Zidi, Fethi, Ailal, Fatima, Attal, Nabila, Doudou, Fatouma, Abbadi, Mohamed-Cherif, Kaddache, Chawki, Smati, Leila, Touri, Nabila, Chemli, Jalel, Gargah, Tahar, Brini, Ines, Bakhchane, Amina, Charoute, Hicham, Jeddane, Leila, El Atiqi, Sara, El Hafidi, Naïma, Hida, Mustapha, Saile, Rachid, Alj, Hanane Salih, Boukari, Rachida, Bejaoui, Mohamed, Najib, Jilali, Barbouche, Mohamed-Ridha, Lau, Yu-Lung, Mellouli, Fethi, and Bousfiha, Ahmed Aziz

Published
2016
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14. Inborn Errors of Immunity in Algerian Children and Adults: A Single-Center Experience Over a Period of 13 Years (2008–2021)

Author

Belaid, Brahim, primary, Lamara Mahammed, Lydia, additional, Drali, Ouardia, additional, Oussaid, Aida Mohand, additional, Touri, Nabila Souad, additional, Melzi, Souhila, additional, Dehimi, Abdelhak, additional, Berkani, Lylia Meriem, additional, Merah, Fatma, additional, Larab, Zineb, additional, Allam, Ines, additional, Khemici, Ouarda, additional, Kirane, Sonya Yasmine, additional, Boutaba, Mounia, additional, Belbouab, Reda, additional, Bekkakcha, Hadjira, additional, Guedouar, Assia, additional, Chelali, Abdelhakim, additional, Baamara, Brahim, additional, Noui, Djamila, additional, Baaziz, Hadda, additional, Rezak, Radia, additional, Azzouz, Sidi Mohamed, additional, Aichaoui, Malika, additional, Moktefi, Assia, additional, Benhatchi, Redha Mohamed, additional, Oussalah, Meriem, additional, Benaissa, Naila, additional, Laredj, Amel, additional, Bouchetara, Assia, additional, Adria, Abdelkader, additional, Habireche, Brahim, additional, Tounsi, Noureddine, additional, Dahmoun, Fella, additional, Touati, Rabah, additional, Boucenna, Hamza, additional, Bouferoua, Fadila, additional, Sekfali, Lynda, additional, Bouhafs, Nadjet, additional, Aboura, Rawda, additional, Kherra, Sakina, additional, Inouri, Yacine, additional, Dib, Saadeddine, additional, Medouri, Nawel, additional, Khelfaoui, Noureddine, additional, Redjedal, Aicha, additional, Zelaci, Amara, additional, Yahiaoui, Samah, additional, Medjadj, Sihem, additional, Touhami, Tahar Khelifi, additional, Kadi, Ahmed, additional, Amireche, Fouzia, additional, Frada, Imane, additional, Houasnia, Shahrazed, additional, Benarab, Karima, additional, Boubidi, Chahynez, additional, Ferhani, Yacine, additional, Benalioua, Hayet, additional, Sokhal, Samia, additional, Benamar, Nadia, additional, Aggoune, Samira, additional, Hadji, Karima, additional, Bellouti, Asma, additional, Rahmoune, Hakim, additional, Boutrid, Nada, additional, Okka, kamelia, additional, Ammour, Assia, additional, Saadoune, Houssem, additional, Amroun, Malika, additional, Belhadj, Hayet, additional, Ghanem, Amina, additional, Abbaz, Hanane, additional, Boudrioua, Sana, additional, Zebiche, Besma, additional, Ayad, Assia, additional, Hamadache, Zahra, additional, Ouaras, Nassima, additional, Achour, Nassima, additional, Bouchair, Nadira, additional, Boudiaf, Houda, additional, Bekkat-Berkani, Dahila, additional, Maouche, Hachemi, additional, Bouzrar, Zahir, additional, Aissat, Lynda, additional, Ibsaine, Ouardia, additional, Bioud, Belkacem, additional, Kedji, Leila, additional, Dahlouk, Djazia, additional, Bensmina, Manoubia, additional, Radoui, Abdelkarim, additional, Bessahraoui, Mimouna, additional, Bensaadi, Nadia, additional, Mekki, Azzeddine, additional, Zeroual, Zoulikha, additional, Chan, Koon-Wing, additional, Leung, Daniel, additional, Tebaibia, Amar, additional, Ayoub, Soraya, additional, Mekideche, Dalila, additional, Gharnaout, Merzak, additional, Casanova, Jean Laurent, additional, Puel, Anne, additional, Lau, Yu Lung, additional, Cherif, Nacira, additional, Ladj, Samir, additional, Smati, Leila, additional, Boukari, Rachida, additional, Benhalla, Nafissa, additional, and Djidjik, Reda, additional

Published
2022
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15. Algerian Registry for Inborn Errors of Immunity in Children: Report of 887 children (1985 - 2021)

Author

Yagoubi, Abdelghani, primary, Tahiat, Azzeddine, additional, Touri, Nabila Souad, additional, Ladj, Mohamed Samir, additional, Drali, Ouardia, additional, Belaid, Brahim, additional, Mohand-Oussaid, Ayda, additional, Dehimi, Abdelhak, additional, Belbouab, Reda, additional, Ferhani, Yacine, additional, Melzi, Souhila, additional, Guedouar, Assia, additional, Hakem, Saliha, additional, Khemici, Ouardia, additional, Inouri, Yacine, additional, Meddour, Yanis, additional, Dib, Saadeddine, additional, Mansouri, Zohra, additional, Iddir, Samir, additional, Boufersaoui, Abderrahmane, additional, Boudiaf, Houda, additional, Bouhdjila, Abderrachid, additional, Ibsaine, Ouardia, additional, Maouche, Hachemi, additional, Dahlouk, Djazia, additional, Mekki, Azzedine, additional, Bioud, Belkacem, additional, Bouzerar, Zahir, additional, Zeroual, Zoulikha, additional, Benhassine, Fadila, additional, Bekkat-Berkani, Dahila, additional, Naamoune, Soumeya, additional, Salah, Samir Sofiane, additional, Chaib, Samia, additional, Attal, Nabila, additional, Bensaadi, Nadia, additional, Bouchair, Nadira, additional, Cherif, Nacira, additional, Kedji, Leila, additional, Bendeddouche, Salih, additional, Atif, Mohamed Lamine, additional, Djenouhat, Kamel, additional, Kechout, Nadia, additional, Djidjik, Reda, additional, Benhalla, Keltoum Nafissa, additional, Smati, Leila, additional, and Boukari, Rachida, additional

Published
2022
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19. Diagnostic and Predictive Contribution of Autoantibodies Screening in a Large Series of Patients With Primary Immunodeficiencies

Author

Tahiat, Azzeddine, primary, Yagoubi, Abdelghani, additional, Ladj, Mohamed Samir, additional, Belbouab, Reda, additional, Aggoune, Samira, additional, Atek, Laziz, additional, Bouziane, Djamila, additional, Melzi, Souhila, additional, Boubidi, Chahinez, additional, Drali, Warda, additional, Bendahmane, Chafa, additional, Iguerguesdaoune, Hamza, additional, Taguemount, Sihem, additional, Soufane, Asma, additional, Oukil, Asma, additional, Ketfi, Abdalbasset, additional, Messaoudi, Hassen, additional, Boukhenfouf, Nadia, additional, Ifri, Mohamed Amine, additional, Bencharif Madani, Tahar, additional, Belhadj, Hayet, additional, Benhala, Keltoum Nafissa, additional, Khiari, Mokhtar, additional, Cherif, Nacera, additional, Smati, Leila, additional, Arada, Zakia, additional, Zeroual, Zoulikha, additional, Bouzerar, Zair, additional, Ibsaine, Ouardia, additional, Maouche, Hachemi, additional, Boukari, Rachida, additional, and Djenouhat, Kamel, additional

Published
2021
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21. Genetic Approaches for Definitive Diagnosis of Agammaglobulinemia in Consanguineous Families

Author

Ben-Ali, Meriem, primary, Kechout, Nadia, additional, Mekki, Najla, additional, Yang, Jing, additional, Chan, Koon Wing, additional, Barakat, Abdelhamid, additional, Aadam, Zahra, additional, Gamara, Jouda, additional, Gargouri, Lamia, additional, Largueche, Beya, additional, BelHadj-Hmida, Nabil, additional, Nedri, Amel, additional, Ameur, Houcine Ben, additional, Mellouli, Fethi, additional, Boukari, Rachida, additional, Bejaoui, Mohamed, additional, Bousfiha, Aziz, additional, Ben-Mustapha, Imen, additional, Lau, Yu-Lung, additional, and Barbouche, Mohamed-Ridha, additional

Published
2019
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22. Consensus Middle East and North Africa Registry on Inborn Errors of Immunity.

Author

Aghamohammadi, Asghar, Rezaei, Nima, Yazdani, Reza, Delavari, Samaneh, Kutukculer, Necil, Topyildiz, Ezgi, Ozen, Ahmet, Baris, Safa, Karakoc-Aydiner, Elif, Kilic, Sara Sebnem, Kose, Hulya, Gulez, Nesrin, Genel, Ferah, Reisli, Ismail, Djenouhat, Kamel, Tahiat, Azzeddine, Boukari, Rachida, Ladj, Samir, Belbouab, Reda, and Ferhani, Yacine

Subjects
AGE of onset, CHILD death, IMMUNITY, GENETIC disorder diagnosis, MOLECULAR diagnosis, SEVERE combined immunodeficiency
Abstract

Background: Inborn errors of immunity (IEIs) are a heterogeneous group of genetic defects of immunity, which cause high rates of morbidity and mortality mainly among children due to infectious and non-infectious complications. The IEI burden has been critically underestimated in countries from middle- and low-income regions and the majority of patients with IEI in these regions lack a molecular diagnosis. Methods: We analyzed the clinical, immunologic, and genetic data of IEI patients from 22 countries in the Middle East and North Africa (MENA) region. The data was collected from national registries and diverse databases such as the Asian Pacific Society for Immunodeficiencies (APSID) registry, African Society for Immunodeficiencies (ASID) registry, Jeffrey Modell Foundation (JMF) registry, J Project centers, and International Consortium on Immune Deficiency (ICID) centers. Results: We identified 17,120 patients with IEI, among which females represented 39.4%. Parental consanguinity was present in 60.5% of cases and 27.3% of the patients were from families with a confirmed previous family history of IEI. The median age of patients at the onset of disease was 36 months and the median delay in diagnosis was 41 months. The rate of registered IEI patients ranges between 0.02 and 7.58 per 100,000 population, and the lowest rates were in countries with the highest rates of disability-adjusted life years (DALY) and death rates for children. Predominantly antibody deficiencies were the most frequent IEI entities diagnosed in 41.2% of the cohort. Among 5871 patients genetically evaluated, the diagnostic yield was 83% with the majority (65.2%) having autosomal recessive defects. The mortality rate was the highest in patients with non-syndromic combined immunodeficiency (51.7%, median age: 3.5 years) and particularly in patients with mutations in specific genes associated with this phenotype (RFXANK, RAG1, and IL2RG). Conclusions: This comprehensive registry highlights the importance of a detailed investigation of IEI patients in the MENA region. The high yield of genetic diagnosis of IEI in this region has important implications for prevention, prognosis, treatment, and resource allocation. [ABSTRACT FROM AUTHOR]

Published
2021
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23. REACH: A programme for improving care in haemophilia

Author

Goga, Yasmin, primary, Boukari, Rachida, additional, Bensadok, Meriem, additional, El Khorassani, Mohamed, additional, Khelif, Abderrahim, additional, Al Rawas, Abdulhakim, additional, Alkasim, Fawaz, additional, Shaheen, Naglaa Mohamad, additional, and Negrier, Claude, additional

Published
2019
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24. Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases

Author

Li, Yue, primary, Führer, Marita, additional, Bahrami, Ehsan, additional, Socha, Piotr, additional, Klaudel-Dreszler, Maja, additional, Bouzidi, Amira, additional, Liu, Yanshan, additional, Lehle, Anna S., additional, Magg, Thomas, additional, Hollizeck, Sebastian, additional, Rohlfs, Meino, additional, Conca, Raffaele, additional, Field, Michael, additional, Warner, Neil, additional, Mordechai, Slae, additional, Shteyer, Eyal, additional, Turner, Dan, additional, Boukari, Rachida, additional, Belbouab, Reda, additional, Walz, Christoph, additional, Gaidt, Moritz M., additional, Hornung, Veit, additional, Baumann, Bernd, additional, Pannicke, Ulrich, additional, Al Idrissi, Eman, additional, Ali Alghamdi, Hamza, additional, Sepulveda, Fernando E., additional, Gil, Marine, additional, de Saint Basile, Geneviève, additional, Hönig, Manfred, additional, Koletzko, Sibylle, additional, Muise, Aleixo M., additional, Snapper, Scott B., additional, Schwarz, Klaus, additional, Klein, Christoph, additional, and Kotlarz, Daniel, additional

Published
2018
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25. Kawarabi: Administrative Structuring of a Multicenter Research Collaborative to Study Kawasaki Disease in the Arab Countries

Author

Arab, Yousra, Harahsheh, Ashraf S., Dahdah, Nagib, El-Kholy, Nermeen, Abed, Maysam Y., Abu Al-Saoud, Sima Y., Agha, Hala M., Alahmadi, Fahad, Alamer, Suad R., Awadhi, Zainab Al, Ali, Sulafa, Ali, Mohamed T., Alrabte, Hanifa, Al-Saloos, Hesham, Al-Senaidi, Khalfan S., Alzyoud, Raed, Awidat, Najat, Bouayed, Kenza, Bouaziz, Asma, Boukari, Rachida, El Ganzoury, Mona M., Elmarsafawy, Hala M., Elrugige, Najat, Fitouri, Zohra, Kotby, Alyaa, Ladj, Mohamed S., Bekkar, Mokhtar, Mouawad, Pierre, Salih, Aso F., Suleiman, Mohamed, and Choueiter, Nadine F.

Abstract

Kawasaki disease (KD), the leading cause of acquired heart disease in children in developed countries, merits conducting detailed studies in Arab countries. We introduce Kawarabi, as a multicenter research collaborative effort dedicated to improving diagnosis, care, and outcome of children and adults with KD in the Arab world. During the COVID-19 pandemic, there emerged a new multisystem inflammatory syndrome in children; a disease similar to KD. This highlighted the challenges that Arab physicians face in diagnosing and managing children with KD and KD-like illnesses. Kawarabi brings together experts in North America and Arab nations to study this family of diseases in a not-for-profit, voluntary scientific collaborative setting. Bylaws addressing the vision, objectives, structure, and governance of Kawarabi were established, and vetted by the 45 organizing members in 2021. An initial scientific publication showed evidence of a decreased level of awareness of the disease in the general population, as well as the lack of access to resources available for physicians caring for children with KD in Arab countries. Kawarabi has since held several educational webinars and an inaugural yearly meeting. The groundwork for future initiatives targeted at increasing awareness and understanding of the management and the long-term outcomes of children with KD in the region was established. Data on KD in the Arab world are lacking. Kawarabi is a multicenter research collaborative organization that has the unique resources, diversified ethnic makeup, and energy, to accomplish significant advances in our understanding and management of KD and its variants.

Published
2024
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26. Pertussis in north-central and northwestern regions of Algeria

Author

Benamrouche, Nabila, primary, Tali Maamar, Hassiba, additional, Lazri, Malika, additional, Hasnaoui, Sonia, additional, Radoui, Abdelkarim, additional, Lafer, Ourida, additional, Boukari, Rachida, additional, Kaddache, Chawki, additional, Arrada, Zakia, additional, and Rahal, Kheira, additional

Published
2016
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27. Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases.

Author

Yue Li, Führer, Marita, Bahrami, Ehsan, Socha, Piotr, Klaudel-Dreszler, Maja, Bouzidi, Amira, Liu, Yanshan, Lehle, Anna S., Magg, Thomas, Hollizeck, Sebastian, Rohlfs, Meino, Conca, Raffaele, Field, Michael, Warner, Neil, Mordechai, Slae, Shteyer, Eyal, Turner, Dan, Boukari, Rachida, Belbouab, Reda, and Walz, Christoph

Subjects
CELL proliferation, PROTEIN kinases, IMMUNODEFICIENCY, INFLAMMASOMES, HOMEOSTASIS
Abstract

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a critical regulator of cell death and inflammation, but its relevance for human disease pathogenesis remains elusive. Studies of monogenic disorders might provide critical insights into disease mechanisms and therapeutic targeting of RIPK1 for common diseases. Here, we report on eight patients from six unrelated pedigrees with biallelic loss-of-function mutations in RIPK1 presenting with primary immunodeficiency and/ or intestinal inflammation. Mutations in RIPK1 were associated with reduced NF-κB activity, defective differentiation of T and B cells, increased inflammasome activity, and impaired response to TNFR1-mediated cell death in intestinal epithelial cells. The characterization of RIPK1-deficient patients highlights the essential role of RIPK1 in controlling human immune and intestinal homeostasis, and might have critical implications for therapies targeting RIPK1. [ABSTRACT FROM AUTHOR]

Published
2019
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30. Eosinophilic pneumonias in children: A review of the epidemiology, diagnosis, and treatment

Author

Giovannini‐Chami, Lisa, primary, Blanc, Sibylle, additional, Hadchouel, Alice, additional, Baruchel, André, additional, Boukari, Rachida, additional, Dubus, Jean‐Christophe, additional, Fayon, Michael, additional, Le Bourgeois, Muriel, additional, Nathan, Nadia, additional, Albertini, Marc, additional, Clément, Annick, additional, and de Blic, Jacques, additional

Published
2015
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34. Statistical Approaches in Identifying Relationships in Disease Background Parameters using Multiple Correspondence Analysis: Case of Atopies in Relation to Asthma.

Author

ERRAHMANI, Mohamed BRAHIM, SAID, Ramdane MOHAMED, HABRAOUI, Fadhila, KADDACHE, Chawki, and BOUKARI, Rachida

Subjects
ATOPY, ASTHMA in children, ALLERGY diagnosis, RHINITIS, BRONCHIOLITIS, DIAGNOSIS
Abstract

The multiple correspondence analysis is a powerful technique to identify groups with similarities relatively to a large sets of parameters, revealing the patterning of complex data sets. Signs of atopies and various allergies were listed in asthmatic children and their closer family. The data analysis has permitted to uncover predominance in children of low ranks of birth, frequency of rhinitis, onset in infancy of bronchiolitis, strong links between rhinitis and conjunctivitis, opposed links between rhinitis and bronchiolitis, and a significant impact of background family history. The multiple correspondence analysis highlighted this importance of family background and showed remarkable groupings in relation to modalities of the studied parameters such as existence of atopic dermatitis children with father more than the mother background, higher propensity of the mother to transmit atopy to her children and the fact the father transmits atopy more to girls than boys. [ABSTRACT FROM AUTHOR]

Published
2013

35. Consensus Middle East and North Africa Registry on Inborn Errors of Immunity

Author

Salem Al-Tamemi, Amel Hassen, Ismail Reisli, André Mégarbané, Waleed Al-Herz, Fred Modell, Gulnara Nasrullayeva, Ahmet Ozen, Jessica Quinn, Elif Karakoc-Aydiner, Nabila Attal, Safa Baris, Reda Djidjik, Nadia Kechout, Ridha Barbouche, László Maródi, Maryam Ali Al-Nesf, Necil Kutukculer, Samir Ladj, Mehdi Adeli, Khalissa Saidani, Ragheed Rizk, Yacine Ferhani, Sara Sebnem Kilic, Mona Al-Ahmed, Vicki Modell, Hassan Abolhassani, Marwa H. Elnagdy, Kamel Djenouhat, Reda Belbouab, Nima Rezaei, Asghar Aghamohammadi, Rachida Boukari, Samaneh Delavari, Carla Irani, Raif S. Geha, Hulya Kose, Nesrin Gulez, Ali Sobh, Ferah Genel, Cybel Mehawej, Ezgi Topyildiz, Azzeddine Tahiat, Aziz Bousfiha, Reza Yazdani, Brahim Belaid, Aghamohammadi, Asghar, Rezaei, Nima, Yazdani, Reza, Delavari, Samaneh, Kutukculer, Necil, Topyildiz, Ezgi, Ozen, Ahmet, Baris, Safa, Karakoc-Aydiner, Elif, Kilic, Sara Sebnem, Kose, Hulya, Gulez, Nesrin, Genel, Ferah, Reisli, Ismail, Djenouhat, Kamel, Tahiat, Azzeddine, Boukari, Rachida, Ladj, Samir, Belbouab, Reda, Ferhani, Yacine, Belaid, Brahim, Djidjik, Reda, Kechout, Nadia, Attal, Nabila, Saidani, Khalissa, Barbouche, Ridha, Bousfiha, Aziz, Sobh, Ali, Rizk, Ragheed, Elnagdy, Marwa H., Al-Ahmed, Mona, Al-Tamemi, Salem, Nasrullayeva, Gulnara, Adeli, Mehdi, Al-Nesf, Maryam, Hassen, Amel, Mehawej, Cybel, Irani, Carla, Megarbane, Andre, Quinn, Jessica, Marodi, Laszlo, Modell, Vicki, Modell, Fred, Al-Herz, Waleed, Geha, Raif S., and Abolhassani, Hassan

Subjects
0301 basic medicine, Adult, Male, Pediatrics, medicine.medical_specialty, Consensus, Adolescent, Epidemiology, Primary Immunodeficiency Diseases, Immunology, Population, Disease, 03 medical and health sciences, Middle East, Young Adult, 0302 clinical medicine, Africa, Northern, Diagnosis, medicine, Immunology and Allergy, Humans, Registries, Family history, education, Child, Immunodeficiency, Aged, education.field_of_study, Primary immunodeficiency, business.industry, Mortality rate, Variants, Genetic Diseases, Inborn, Burden of disease, Disability-Adjusted Life Years, Inborn errors of immunity, Middle Aged, medicine.disease, 030104 developmental biology, Cohort, Female, Original Article, Molecular diagnosis, business, 030215 immunology
Abstract

Background Inborn errors of immunity (IEIs) are a heterogeneous group of genetic defects of immunity, which cause high rates of morbidity and mortality mainly among children due to infectious and non-infectious complications. The IEI burden has been critically underestimated in countries from middle- and low-income regions and the majority of patients with IEI in these regions lack a molecular diagnosis. Methods We analyzed the clinical, immunologic, and genetic data of IEI patients from 22 countries in the Middle East and North Africa (MENA) region. The data was collected from national registries and diverse databases such as the Asian Pacific Society for Immunodeficiencies (APSID) registry, African Society for Immunodeficiencies (ASID) registry, Jeffrey Modell Foundation (JMF) registry, J Project centers, and International Consortium on Immune Deficiency (ICID) centers. Results We identified 17,120 patients with IEI, among which females represented 39.4%. Parental consanguinity was present in 60.5% of cases and 27.3% of the patients were from families with a confirmed previous family history of IEI. The median age of patients at the onset of disease was 36 months and the median delay in diagnosis was 41 months. The rate of registered IEI patients ranges between 0.02 and 7.58 per 100,000 population, and the lowest rates were in countries with the highest rates of disability-adjusted life years (DALY) and death rates for children. Predominantly antibody deficiencies were the most frequent IEI entities diagnosed in 41.2% of the cohort. Among 5871 patients genetically evaluated, the diagnostic yield was 83% with the majority (65.2%) having autosomal recessive defects. The mortality rate was the highest in patients with non-syndromic combined immunodeficiency (51.7%, median age: 3.5 years) and particularly in patients with mutations in specific genes associated with this phenotype (RFXANK, RAG1, and IL2RG). Conclusions This comprehensive registry highlights the importance of a detailed investigation of IEI patients in the MENA region. The high yield of genetic diagnosis of IEI in this region has important implications for prevention, prognosis, treatment, and resource allocation., Karolinska Institute, Open access funding provided by Karolinska Institute.

Published
2021

36. Flow cytometry-based diagnostic approach for inborn errors of immunity: experience from Algeria.

Author

Tahiat A, Belbouab R, Yagoubi A, Hakem S, Fernini F, Keddari M, Belhadj H, Touri S, Aggoune S, Stoddard J, Niemela J, Zerifi F, Melzi S, Aboura R, Saad-Djaballah A, Ferhani Y, Ketfi A, Messaoudi H, Bencharif Madani T, Benhacine Z, Dehimi A, Okka K, Amroune F, Fellahi M, Bendahmane C, Khoulani R, Oukil A, Soufane A, Bourelaf I, Boubidi C, Boukhenfouf N, Amine Ifri M, Khelafi N, Boudiaf H, Khelifi Touhami T, Meçabih F, Boucelma M, Zelaci A, Gacem O, Ladj MS, Mekki A, Bensaadi N, Benhalima M, Zeroual Z, Bioud B, Benameur M, Bouhdjila R, Bouzerar Z, Ibsaine O, Maouche H, Kedji L, Smati L, Boukari R, Lambert C, Rosenzweig SD, Notarangelo LD, and Djenouhat K

Subjects
Humans, Male, Female, Algeria, Child, Child, Preschool, Infant, Adolescent, Adult, Retrospective Studies, Immunophenotyping, Young Adult, Infant, Newborn, Immunologic Deficiency Syndromes diagnosis, Immunologic Deficiency Syndromes immunology, Immunologic Deficiency Syndromes genetics, Flow Cytometry methods
Abstract

Purpose: In this study, we retrospectively reviewed the use of flow cytometry (FCM) in the diagnosis of inborn errors of immunity (IEIs) at a single center in Algeria. Sharing insights into our practical experience, we present FCM based diagnostic approaches adapted to different clinical scenarios., Methods: Between May 2017 and February 2024, pediatric and adult patients presenting with clinical features suggestive of immunodeficiency were subjected to FCM evaluation, including lymphocyte subset analysis, detection of specific surface or intracellular proteins, and functional analysis of immune cells., Results: Over a nearly seven-year period, our laboratory diagnosed a total of 670 patients (372 (55.5%) males and 298 (44.5%) females), distributed into 70 different IEIs belonging to 9 different categories of the International Union of Immunological Societies classification. FCM was used to diagnose and categorize IEI in 514 patients (76.7%). It provided direct diagnostic insights for IEIs such as severe combined immunodeficiency, Omenn syndrome, MHC class II deficiency, familial hemophagocytic lymphohistiocytosis, and CD55 deficiency. For certain IEIs, including hyper-IgE syndrome, STAT1-gain of function, autoimmune lymphoproliferative syndrome, and activated PI3K delta syndrome, FCM offered suggestive evidence, necessitating subsequent genetic testing for confirmation. Protein expression and functional assays played a crucial role in establishing definitive diagnoses for various disorders. To setup such diagnostic assays at high and reproducible quality, high level of expertise is required; in house reference values need to be determined and the parallel testing of healthy controls is highly recommended., Conclusion: Flow cytometry has emerged as a highly valuable and cost-effective tool for diagnosing and studying most IEIs, particularly in low-income countries where access to genetic testing can be limited. FCM analysis could provide direct diagnostic insights for most common IEIs, offer clues to the underlying genetic defects, and/or aid in narrowing the list of putative genes to be analyzed., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Tahiat, Belbouab, Yagoubi, Hakem, Fernini, Keddari, Belhadj, Touri, Aggoune, Stoddard, Niemela, Zerifi, Melzi, Aboura, Saad-Djaballah, Ferhani, Ketfi, Messaoudi, Bencharif Madani, Benhacine, Dehimi, Okka, Amroune, Fellahi, Bendahmane, Khoulani, Oukil, Soufane, Bourelaf, Boubidi, Boukhenfouf, Amine Ifri, Khelafi, Boudiaf, Khelifi Touhami, Meçabih, Boucelma, Zelaci, Gacem, Ladj, Mekki, Bensaadi, Benhalima, Zeroual, Bioud, Benameur, Bouhdjila, Bouzerar, Ibsaine, Maouche, Kedji, Smati, Boukari, Lambert, Rosenzweig, Notarangelo and Djenouhat.)

Published
2024
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37. Primary Immunodeficiencies: Epidemiology in the Maghreb.

Author

Bousfiha AA, Errami A, Jeddane L, Mellouli F, Reda SM, Adeli M, Al-Herz W, Zyoud R, Erwa N, Suleiman Y, Boukari R, Dakkoune M, Yagoubi A, Al-Mousa H, Arnaout R, Alhamadi S, Bejaoui M, Barbouche MR, AlSaoud B, and Al-Dhekri H

Subjects
Africa epidemiology, Africa, Northern epidemiology, Algeria epidemiology, Asia epidemiology, Consanguinity, Europe epidemiology, Humans, Immunologic Deficiency Syndromes genetics, Incidence, Middle East epidemiology, Morocco epidemiology, Prevalence, Registries statistics & numerical data, Statistics as Topic standards, Tunisia epidemiology, United States epidemiology, Immunologic Deficiency Syndromes epidemiology
Abstract

Introduction: Primary Immunodeficiency (PIDs) is a set of 330 rare hereditary diseases that increase susceptibility to infections, allergies, autoimmunity, and neoplasia. North American registries give higher prevalence than Maghreb ones, whereas consanguinity is high. The purpose of this study is to compare prevalence and coverage rate of Maghreb PID registries with estimates based on USA., Methods: We searched the prevalence of PIDs in the Maghreb registers. Next, we estimated the expected values based on recent publications. Finally, we calculated the coverage rate of the Maghreb registries compared to the new estimates and we evaluated the impact of consanguinity., Results: The total number is N1 = 2456 patients. The current Maghreb PID Prevalence is 2.56 / 100,000 inhabitants (population of 94,804,694 Million in 2017). Tunisia leads with a prevalence of 8.70 followed by Morocco 2.09, Libya 1.65 and Algeria 1.46/100.000 habitants. We did not find values for Mauritania. If we extrapolate the prevalence of the USA to the Maghreb population, the number of patients in the Maghreb would be N2 = 27,588 and the coverage rate (N1 / N2) would be 8.90%. This low coverage rate is however better than the World average (1.21%), that of Latin America 1.19% and Africa 0.36%. The Maghreb prevalence is close to that of the Arab world 2.04 / 100,000 (population of 391,449,544 in 2017). Using the incidence found in the USA, the number of patients would be 9765 new patients per year in the Maghreb and 40,319 in Arab countries., Conclusion: PID Maghreb patients number is very low compared to global estimates, whereas consanguinity is very high. Special attention should be given to PIDs by governments and research teams in this region.

Published
2018

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