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1. MQTT Protocol Analysis According to QoS Levels and SSL Implementation for IoT Systems

Author

Boujrad, Mouna, Kasmi, Mohammed Amine, Ouerdi, Noura, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Ezziyyani, Mostafa, editor, and Balas, Valentina Emilia, editor

Published
2023
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3. Conceptual design of the AGATA 2[formula omitted] array at LNL

Author

Valiente-Dobón, J.J., Menegazzo, R., Goasduff, A., Agguiaro, D., Aguilera, P., Angelini, F., Balogh, M., Bazzacco, D., Benito, J., Benzoni, G., Bez, N., Bolognesi, M., Bottoni, S., Brugnara, D., Carollo, S., Cocconi, P., Cogo, A., Collado, J., Crespi, F.C.L., Ertoprak, A., Escudeiro, R., Galtarossa, F., Gamba, E.R., Gambalonga, A., Servín, B. Góngora, Gottardo, A., Gozzelino, A., Gulmini, M., Huang, Z., Marchi, T., Mengoni, D., Modanese, P., Napoli, D.R., Pellumaj, J., Pérez-Vidal, R.M., Pigliapoco, S., Pilotto, E., Ramina, L., Rampazzo, M., Raniero, W., Rebeschini, M., Rezynkina, K., Rosso, D., Scarcioffolo, M., Scarpa, D., Sedlák, M., Smith, R., Toniolo, N., Veronese, F., Volpe, V., Zago, L., Zanon, I., Zhang, G., Abels, R., Allegrini, M.L., Aufranc, C., Baulieu, G., Belkhiria, C., Benettoni, M., Benini, D., Bentley, M., Biasotto, M., Blaizot, M., Miquel, J. Blasco, Boiano, C., Boston, A., Boston, H., Boujrad, A., Bourgault, P., Bracco, A., Brambilla, S., Burrows, I., Camera, F., Capra, S., Capsoni, A., Cash, R., Civera, J.V., Clément, E., Coelli, S., Cordwell, M., Corradi, L., Coudert, S., De Angelis, G., De Ruvo, L., Debras, G., Del Fabbro, M., Diklić, J., Dosme, N., Duchene, G., Duclos, B., Dudouet, J., Eberth, J., Elloumi, S., Everett, C., Fantinel, S., Fillinger, M., Fioretto, E., Fransen, C., Gadea, A., Gibelin, L., González, V., Goupil, J., Görgen, C., Grant, A., Green, K., Ha, J., Hartnett, T., Henseler, K., Hess, H., Hirsch, R., Houarner, C., Jacob, J., Joannem, T., Judson, D.S., Karkour, N., Karolak, M., Kebbiri, M., Kieffer, J., Labiche, M., Lafay, X., Le Jeannic, P., Lefevre, A., Legay, E., Legruel, F., Lenzi, S., Leoni, S., Linget, D., Liptrot, M., López-Martens, A., Lotodé, A., Manara, L., Ménager, L., Mijatović, T., Million, B., Minarello, A., Montagnoli, G., Morrall, P., Mullacrane, I., Nyberg, J., Philippon, G., Polettini, M., Popieul, F., Pullia, A., Recchia, F., Reiter, P., Richardt, G., Rocchini, M., Roger, A., Saillant, F., Sanchis, E., Laskar, Md.S.R., Secci, G., Sigward, M.-H., Simpson, J., Solenne, N., Spee, F., Stefanini, A.M., Stézowski, O., Szilner, S., Templeton, N., Theisen, Ch., Thiel, S., Tomasi, F., Tzvetkov, S., Vigano, D., Viscione, E., Wieland, O., Wimmer, K., Wittwer, G., and Zielińska, M.

Published
2023
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4. AGATA phase 2 advancements in front-end electronics

Author

Collado, J., Capra, S., Pullia, A., Karkour, N., Houarner, Ch., Gonzalez, V., Wittwer, G., Boujrad, A., Kogimtzis, M., Lawson, J., Goasduff, A., Stezowski, O., Bonnin, Ch., Charles, L., Alaphilippe, V., Dosme, N., Esnault, C., Gibelin, L., Lafay, X., Legay, E., Linget, D., Cahoreau, M., Sidler, D., Vinther-Jørgensen, G., Civera, J. V., Duchêne, G., Clément, E., Lazarus, I., and Gadea, A.

Published
2023
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5. A New Artificial Intelligence-Based Strategy for Digital Marketing Reinforcement

Author

Boujrad, Mouna, lamlili, Yasser el Mazoui Nadori, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Ben Ahmed, Mohamed, editor, Rakıp Karaș, İsmail, editor, Santos, Domingos, editor, Sergeyeva, Olga, editor, and Boudhir, Anouar Abdelhakim, editor

Published
2021
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9. Conceptual design of the AGATA 2π array at LNL

Author

Valiente-Dobón, J.J., primary, Menegazzo, R., additional, Goasduff, A., additional, Agguiaro, D., additional, Aguilera, P., additional, Angelini, F., additional, Balogh, M., additional, Bazzacco, D., additional, Benito, J., additional, Benzoni, G., additional, Bez, N., additional, Bolognesi, M., additional, Bottoni, S., additional, Brugnara, D., additional, Carollo, S., additional, Cocconi, P., additional, Cogo, A., additional, Collado, J., additional, Crespi, F.C.L., additional, Ertoprak, A., additional, Escudeiro, R., additional, Galtarossa, F., additional, Gamba, E.R., additional, Gambalonga, A., additional, Servín, B. Góngora, additional, Gottardo, A., additional, Gozzelino, A., additional, Gulmini, M., additional, Huang, Z., additional, Marchi, T., additional, Mengoni, D., additional, Modanese, P., additional, Napoli, D.R., additional, Pellumaj, J., additional, Pérez-Vidal, R.M., additional, Pigliapoco, S., additional, Pilotto, E., additional, Ramina, L., additional, Rampazzo, M., additional, Raniero, W., additional, Rebeschini, M., additional, Rezynkina, K., additional, Rosso, D., additional, Scarcioffolo, M., additional, Scarpa, D., additional, Sedlák, M., additional, Smith, R., additional, Toniolo, N., additional, Veronese, F., additional, Volpe, V., additional, Zago, L., additional, Zanon, I., additional, Zhang, G., additional, Abels, R., additional, Allegrini, M.L., additional, Aufranc, C., additional, Baulieu, G., additional, Belkhiria, C., additional, Benettoni, M., additional, Benini, D., additional, Bentley, M., additional, Biasotto, M., additional, Blaizot, M., additional, Miquel, J. Blasco, additional, Boiano, C., additional, Boston, A., additional, Boston, H., additional, Boujrad, A., additional, Bourgault, P., additional, Bracco, A., additional, Brambilla, S., additional, Burrows, I., additional, Camera, F., additional, Capra, S., additional, Capsoni, A., additional, Cash, R., additional, Civera, J.V., additional, Clément, E., additional, Coelli, S., additional, Cordwell, M., additional, Corradi, L., additional, Coudert, S., additional, De Angelis, G., additional, De Ruvo, L., additional, Debras, G., additional, Del Fabbro, M., additional, Diklić, J., additional, Dosme, N., additional, Duchene, G., additional, Duclos, B., additional, Dudouet, J., additional, Eberth, J., additional, Elloumi, S., additional, Everett, C., additional, Fantinel, S., additional, Fillinger, M., additional, Fioretto, E., additional, Fransen, C., additional, Gadea, A., additional, Gibelin, L., additional, González, V., additional, Goupil, J., additional, Görgen, C., additional, Grant, A., additional, Green, K., additional, Ha, J., additional, Hartnett, T., additional, Henseler, K., additional, Hess, H., additional, Hirsch, R., additional, Houarner, C., additional, Jacob, J., additional, Joannem, T., additional, Judson, D.S., additional, Karkour, N., additional, Karolak, M., additional, Kebbiri, M., additional, Kieffer, J., additional, Labiche, M., additional, Lafay, X., additional, Le Jeannic, P., additional, Lefevre, A., additional, Legay, E., additional, Legruel, F., additional, Lenzi, S., additional, Leoni, S., additional, Linget, D., additional, Liptrot, M., additional, López-Martens, A., additional, Lotodé, A., additional, Manara, L., additional, Ménager, L., additional, Mijatović, T., additional, Million, B., additional, Minarello, A., additional, Montagnoli, G., additional, Morrall, P., additional, Mullacrane, I., additional, Nyberg, J., additional, Philippon, G., additional, Polettini, M., additional, Popieul, F., additional, Pullia, A., additional, Recchia, F., additional, Reiter, P., additional, Richardt, G., additional, Rocchini, M., additional, Roger, A., additional, Saillant, F., additional, Sanchis, E., additional, Laskar, Md.S.R., additional, Secci, G., additional, Sigward, M.-H., additional, Simpson, J., additional, Solenne, N., additional, Spee, F., additional, Stefanini, A.M., additional, Stézowski, O., additional, Szilner, S., additional, Templeton, N., additional, Theisen, Ch., additional, Thiel, S., additional, Tomasi, F., additional, Tzvetkov, S., additional, Vigano, D., additional, Viscione, E., additional, Wieland, O., additional, Wimmer, K., additional, Wittwer, G., additional, and Zielińska, M., additional

Published
2023
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10. Vomissements associés à une stagnation pondérale et convulsions : penser à une anomalie du cycle d'urée

Author

Brahim El Hasbaoui, Saloua Boujrad, Rachid Abilkacem, and Aomar Agadr

Subjects
anomalie du cycle de l´urée, vomissement, stagnation pondérale, hyperammoniémie, Medicine
Abstract

Dans certaines maladies métaboliques héréditaires, les vomissements peuvent apparaître comme un symptôme étant au premier plan, en particulier les anomalies du cycle de l'urée, qui sont habituellement diagnostiqués en période néonatale ou dans l'enfance. Nous en rapportons un cas de révélation tardive par un état de mal convulsif. Nous rapportons le cas d'une patiente âgée de 13 ans, qui a été hospitalisé pour prise en charge d'un état de mal convulsif et un retard staturo-pondéral. L'interrogatoire a révélé la notion de vomissements chroniques avec des troubles du comportement, ralentissement idéomoteur et céphalées. L'examen a trouvé une ataxie. La ponction lombaire et le scanner cérébral sont normaux. Une ammoniémie nettement augmentée est mise en évidence 75 micromoles/l (11-50). La chromatographie des acides aminés dans le sang a montré une augmentation de la glutamine et de l'alanine, La chromatographie des acides aminés dans les urines a montré une augmentation des acides aminés basiques évoquant un déficit du cycle de l'urée par déficit de l'enzyme Argininosuccinate lyase. La patiente a été traité en urgence par une alimentation exclusivement glucidolipidique, et par benzoate de sodium permettant une amélioration de l'état clinique, et une reprise de poids. Les crises convulsives ont été maîtrisées par le phénobarbital. L'enquête familiale a trouvé une s�ur âgée de 20 ans suivie depuis l'âge de 3 ans pour crises convulsives traité par le phénobarbital dont le bilan métabolique réalisé dans notre service a objectivé la même anomalie du cycle de l'urée que sa s�ur. A tout âge, devant une encéphalopathie avec épilepsie, vomissement, stagnation pondérale et hyperammoniémie, il faut penser à un déficit du cycle de l'urée. Le diagnostic est très souvent posé lors d'un accès neuro-digestif aigue associant vomissements, troubles de conscience et/ou crises convulsives.

Published
2018
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11. Conceptual design of the AGATA 2π array at LNL

Author

J.J. Valiente-Dobón, R. Menegazzo, A. Goasduff, D. Agguiaro, P. Aguilera, F. Angelini, M. Balogh, D. Bazzacco, J. Benito, G. Benzoni, N. Bez, M. Bolognesi, S. Bottoni, D. Brugnara, S. Carollo, P. Cocconi, A. Cogo, J. Collado, F.C.L. Crespi, A. Ertoprak, R. Escudeiro, F. Galtarossa, E.R. Gamba, A. Gambalonga, B. Góngora Servín, A. Gottardo, A. Gozzelino, M. Gulmini, Z. Huang, T. Marchi, D. Mengoni, P. Modanese, D.R. Napoli, J. Pellumaj, R.M. Pérez-Vidal, S. Pigliapoco, E. Pilotto, L. Ramina, M. Rampazzo, W. Raniero, M. Rebeschini, K. Rezynkina, D. Rosso, M. Scarcioffolo, D. Scarpa, M. Sedlák, R. Smith, N. Toniolo, F. Veronese, V. Volpe, L. Zago, I. Zanon, G. Zhang, R. Abels, M.L. Allegrini, C. Aufranc, G. Baulieu, C. Belkhiria, M. Benettoni, D. Benini, M. Bentley, M. Biasotto, M. Blaizot, J. Blasco Miquel, C. Boiano, A. Boston, H. Boston, A. Boujrad, P. Bourgault, A. Bracco, S. Brambilla, I. Burrows, F. Camera, S. Capra, A. Capsoni, R. Cash, J.V. Civera, E. Clément, S. Coelli, M. Cordwell, L. Corradi, S. Coudert, G. De Angelis, L. De Ruvo, G. Debras, M. Del Fabbro, J. Diklić, N. Dosme, G. Duchene, B. Duclos, J. Dudouet, J. Eberth, S. Elloumi, C. Everett, S. Fantinel, M. Fillinger, E. Fioretto, C. Fransen, A. Gadea, L. Gibelin, V. González, J. Goupil, C. Görgen, A. Grant, K. Green, J. Ha, T. Hartnett, K. Henseler, H. Hess, R. Hirsch, C. Houarner, J. Jacob, T. Joannem, D.S. Judson, N. Karkour, M. Karolak, M. Kebbiri, J. Kieffer, M. Labiche, X. Lafay, P. Le Jeannic, A. Lefevre, E. Legay, F. Legruel, S. Lenzi, S. Leoni, D. Linget, M. Liptrot, A. López-Martens, A. Lotodé, L. Manara, L. Ménager, T. Mijatović, B. Million, A. Minarello, G. Montagnoli, P. Morrall, I. Mullacrane, J. Nyberg, G. Philippon, M. Polettini, F. Popieul, A. Pullia, F. Recchia, P. Reiter, G. Richardt, M. Rocchini, A. Roger, F. Saillant, E. Sanchis, Md.S.R. Laskar, G. Secci, M.-H. Sigward, J. Simpson, N. Solenne, F. Spee, A.M. Stefanini, O. Stézowski, S. Szilner, N. Templeton, Ch. Theisen, S. Thiel, F. Tomasi, S. Tzvetkov, D. Vigano, E. Viscione, O. Wieland, K. Wimmer, G. Wittwer, M. Zielińska, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
AGATA spectrometer, DANTE detector, EUCLIDES detector, LNL facility, Plunger device, PRISMA spectrometer, Pulse shape analysis, TRACE detector, γ-ray tracking, Nuclear and High Energy Physics, Settore FIS/04 - Fisica Nucleare e Subnucleare, ray tracking, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation
Abstract

International audience; The Advanced GAmma Tracking Array (AGATA) has been installed at Laboratori Nazionali di Legnaro (LNL), Italy. In this installation, AGATA will consist, at the beginning, of 13 AGATA triple clusters (ATCs) with an angular coverage of 1π, and progressively the number of ATCs will increase up to a 2π angular coverage. This setup will exploit both stable and radioactive ion beams delivered by the Tandem–PIAVE-ALPI accelerator complex and the SPES facility. The new implementation of AGATA at LNL will be used in two different configurations, firstly one coupled to the PRISMA large-acceptance magnetic spectrometer and lately a second one at Zero Degrees, along the beam line. These two configurations will allow us to cover a broad physics program, using different reaction mechanisms, such as Coulomb excitation, fusion-evaporation, transfer and fission at energies close to the Coulomb barrier. These setups have been designed to be coupled with a large variety of complementary detectors such as charged particle detectors, neutron detectors, heavy-ion detectors, high-energy γ-ray arrays, cryogenic and gasjet targets and the plunger device for lifetime measurements. We present in this paper the conceptual design, characteristics and performance figures of this implementation of AGATA at LNL.

Published
2023

12. AGATA phase 2 advancements in front-end electronics

Author

Collado, J, Capra, S, Pullia, A, Karkour, N, Houarner, Ch, Gonzalez, V, Wittwer, G, Boujrad, A, Kogimtzis, M, Lawson, J, Goasduff, A, Stezowski, O, Bonnin, Ch, Charles, L, Alaphilippe, V, Dosme, N, Esnault, C, Gibelin, L, Lafay, X, Legay, E, Linget, D, Cahoreau, M, Sidler, D, Vinther-Jørgensen, G, Civera, J.V, Duchêne, G, Clément, E, Lazarus, I, Gadea, A, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Abstract

International audience; The AGATA collaboration has a long-standing leadership in the development of front-end electronics for high resolution $\gamma $-ray spectroscopy using large volume high purity germanium detectors. For two decades, the AGATA collaboration has been developing state-of-the-art digital electronics processing with high resolution sampling ADC, high-speed signal transfer and fast readout to a high throughput computing (HTC) farm for on-line pulse shape analysis. The collaboration is presently addressing the next challenge of equipping a 4$\pi $ array with more than 6000 channels in high resolution mode, generating approximately 10 MHz of total trigger requests, coupled to a large variety of complementary instruments. A next generation of front-end electronics, presently under design, is based on industrial products (System on Module FPGA’s), has higher integration and lower power consumption. In this contribution, the conceptual design of the new electronics is presented. The results of the very first tests of the pre-production electronics are presented as well as future perspectives.

Published
2023

13. Déficit congénital en facteur V: à propos d'un cas

Author

Saloua Boujrad, Brahim El Hasbaoui, Hanae Echahdi, Mohamed Malih, and Aomar Agadr

Subjects
déficit congénital en facteur v, épistaxis, circoncision, plasma frais congelé, Medicine
Abstract

Le déficit congénital en facteur V est une anomalie rare de la coagulation, initialement décrite par Owren en 1947 et connue sous le nom de para hémophilie. Elle est transmise selon un mode autosomique récessif, et est généralement symptomatique à l'état homozygote. Le facteur V est un cofacteur essentiel dans la conversion de la prothrombine en thrombine par le facteur X activé. En l'absence du facteur V, la génération de thrombine est ralentie et la formation de fibrine retardée. Il en résulte une tendance aux saignements. Nous rapportons un cas de déficit congénital en facteur V chez un nourrisson présentant des épistaxis à répétition.

Published
2017
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18. NEDA—NEutron Detector Array

Author

Valiente-Dobón, J. J., Jaworski, G., Goasduff, A., Egea, F. J., Modamio, V., Hüyük, T., Triossi, A., Jastrząb, M., Söderström, P. A., Di Nitto, A., de Angelis, G., de France, G., Erduran, N., Gadea, A., Moszyński, M., Nyberg, J., Palacz, M., Wadsworth, R., Aliaga, R., Aufranc, C., Bézard, M., Baulieu, G., Bissiato, E., Boujrad, A., Burrows, I., Carturan, S., Cocconi, P., Colucci, G., Conventi, D., Cordwell, M., Coudert, S., Deltoro, J. M., Ducroux, L., Dupasquier, T., Ertürk, S., Fabian, X., González, V., Grant, A., Hadyńska-Klęk, K., Illana, A., Jurado-Gomez, M. L., Kogimtzis, M., Lazarus, I., Legeard, L., Ljungvall, J., Pasqualato, G., Pérez-Vidal, R. M., Raggio, A., Ralet, D., Redon, N., Saillant, F., Sayğı, B., Sanchis, E., Scarcioffolo, M., Siciliano, M., Testov, D., Stezowski, O., Tripon, M., Zanon, I., Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Valiente-Dobón, J.J., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Jaworski, G., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Goasduff, A., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy, Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy -- Egea, F.J., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy, Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy, Instituto de Física Corpuscular, CSIC-Universidad deValencia, E-46980 Paterna (Valencia), Spain -- Modamio, V., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy, Department of Physics, University of Oslo, Oslo, N-0316, Norway -- Hüyük, T., Instituto de Física Corpuscular, CSIC-Universidad deValencia, E-46980 Paterna (Valencia), Spain -- Triossi, A., Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy, CERN, Switzerland -- Jastrzab, M., Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Kraków, Poland -- Söderström, P.A., Extreme Light Infrastructureuclear Physics (ELI-NP), 077125 Bucharest-Magurele, Romania -- Di Nitto, A., Helmholtz Institute Mainz and GSI Helmholtzzentrum für Schwerionenforschund, Darmstadt, Germany -- de Angelis, G., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- de France, G., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Erduran, N., Faculty of Engineering and Natural Sciences, Istanbul Sabahattin Zaim University, Istanbul, 34303, Turkey -- Gadea, A., Instituto de Física Corpuscular, CSIC-Universidad deValencia, E-46980 Paterna (Valencia), Spain -- Moszynski, M., National Centre for Nuclear Research, 05-400 Otwock-Swierk, Poland -- Nyberg, J., Department of Physics and Astronomy, Uppsala University, SE-75120 Uppsala, Sweden -- Palacz, M., Heavy Ion Laboratory, University of Warsaw, Warsaw, 02-093, Poland -- Wadsworth, R., Department of Physics, University of York, Heslington, YO10 5DD York, United Kingdom -- Aliaga, R., Instituto de Física Corpuscular, CSIC-Universidad deValencia, E-46980 Paterna (Valencia), Spain -- Aufranc, C., Université Lyon 1, CNRS, IN2P3, IPN Lyon, Villeurbanne, F-69622, France -- Bézard, M., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Baulieu, G., Université Lyon 1, CNRS, IN2P3, IPN Lyon, Villeurbanne, F-69622, France -- Bissiato, E., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Boujrad, A., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Burrows, I., STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, United Kingdom -- Carturan, S., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy, Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy -- Cocconi, P., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Colucci, G., Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy -- Conventi, D., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Cordwell, M., STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, United Kingdom -- Coudert, S., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Deltoro, J.M., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Ducroux, L., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Dupasquier, T., Université Lyon 1, CNRS, IN2P3, IPN Lyon, Villeurbanne, F-69622, France -- Ertürk, S., Department of Physics, Nigde Omer Halisdemir University, Nigde, 51240, Turkey -- Fabian, X., Université Lyon 1, CNRS, IN2P3, IPN Lyon, Villeurbanne, F-69622, France -- González, V., Departamento de Ingeniería Electrónica, Universidad de Valencia. Avda. Universidad s/n, Burjassot, 46100, Spain -- Grant, A., STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, United Kingdom -- Hadynska-Klek, K., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy, Department of Physics, University of Surrey, Guildford, GU2 7XH, United Kingdom -- Illana, A., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Jurado-Gomez, M.L., Instituto de Física Corpuscular, CSIC-Universidad deValencia, E-46980 Paterna (Valencia), Spain -- Kogimtzis, M., STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, United Kingdom -- Lazarus, I., STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, United Kingdom -- Legeard, L., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Ljungvall, J., CSNSM, CNRS, IN2P3, Université Paris-Sud, Orsay, F-91405, France -- Pasqualato, G., Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy -- Pérez-Vidal, R.M., Instituto de Física Corpuscular, CSIC-Universidad deValencia, E-46980 Paterna (Valencia), Spain -- Raggio, A., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Ralet, D., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Redon, N., Université Lyon 1, CNRS, IN2P3, IPN Lyon, Villeurbanne, F-69622, France -- Saillant, F., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Sayğı, B., Department of Physics, Faculty of Science, University of Ege, Izmir, 35100, Turkey -- Sanchis, E., Departamento de Ingeniería Electrónica, Universidad de Valencia. Avda. Universidad s/n, Burjassot, 46100, Spain -- Scarcioffolo, M., Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy -- Siciliano, M., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Testov, D., Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy -- Stezowski, O., Université Lyon 1, CNRS, IN2P3, IPN Lyon, Villeurbanne, F-69622, France -- Tripon, M., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Zanon, I., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy, Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), 0-Belirlenecek, Ege Üniversitesi, Valiente-Dobón, J. J., Jaworski, G., Goasduff, A., Egea, F. J., Modamio, V., Hüyük, T., Triossi, A., Jastrząb, M., Söderström, P. A., Di Nitto, A., de Angelis, G., de France, G., Erduran, N., Gadea, A., Moszyński, M., Nyberg, J., Palacz, M., Wadsworth, R., Aliaga, R., Aufranc, C., Bézard, M., Baulieu, G., Bissiato, E., Boujrad, A., Burrows, I., Carturan, S., Cocconi, P., Colucci, G., Conventi, D., Cordwell, M., Coudert, S., Deltoro, J. M., Ducroux, L., Dupasquier, T., Ertürk, S., Fabian, X., González, V., Grant, A., Hadyńska-Klęk, K., Illana, A., Jurado-Gomez, M. L., Kogimtzis, M., Lazarus, I., Legeard, L., Ljungvall, J., Pasqualato, G., Pérez-Vidal, R. M., Raggio, A., Ralet, D., Redon, N., Saillant, F., Sayğı, B., Sanchis, E., Scarcioffolo, M., Siciliano, M., Testov, D., Stezowski, O., Tripon, M., and Zanon, I.

Subjects
Nuclear and High Energy Physics, Neutron-gamma discrimination, Liquid scintillator, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Neutron detector, Digital electronic, NEDA, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 16. Peace & justice, Digital electronics, 01 natural sciences, 0103 physical sciences, Nuclear structure, Gamma-ray spectroscopy, 010306 general physics, Nuclear Experiment, Instrumentation, Nuclear and High Energy Physic
Abstract

Millan, Vicente Gonzalez/0000-0001-6014-2586; Huyuk, Tayfun/0000-0003-0597-9767; GOASDUFF, Alain/0000-0003-3453-3297; carturan, sara maria/0000-0002-6702-2867; Sison, Andres Illana/0000-0003-0274-3388; SAYGI, BAHADIR/0000-0001-5406-506X; Jaworski, Grzegorz/0000-0003-2241-0329; Aliaga, Ramon J./0000-0002-2513-7711; Vidal, Rosa Maria Perez/0000-0002-4075-4152; Di Nitto, Antonio/0000-0002-9319-366X; Lazarus, Ian/0000-0003-1235-4984; Hadynska Klek, Katarzyna/0000-0003-1244-9561; Sanchis Peris, Enrique/0000-0002-9689-9131; Moszynski, Marek/0000-0002-1267-2838; Soderstrom, Par-Anders/0000-0002-9504-2814, WOS: 000462142700010, The NEutron Detector Array, NEDA, will form the next generation neutron detection system that has been designed to be operated in conjunction with gamma-ray arrays, such as the tracking-array AGATA, to aid nuclear spectroscopy studies. NEDA has been designed to be a versatile device, with high-detection efficiency, excellent neutron-gamma discrimination, and high rate capabilities. It will be employed in physics campaigns in order to maximise the scientific output, making use of the different stable and radioactive ion beams available in Europe. the first implementation of the neutron detector array NEDA with AGATA 1 pi was realised at GANIL. This manuscript reviews the various aspects of NEDA., Swedish Research Council, SwedenSwedish Research Council [VR 2014-6644]; Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [117F114, 114F473]; Polish National Science Centre, Poland [2017/25/B/ST2/01569, 2016/22/M/ST2/00269 COPIN-IN2P3]; COPIGAL projects, Poland; UK STFCScience & Technology Facilities Council (STFC) [ST/J000124/1, ST/L005727/1, STL005735/1, ST/P003885/1]; Generalitat ValencianaGeneralitat Valenciana [PROMETEO II/2014/019, FPA2017-84756-C4]; MICIU, Spain [PROMETEO II/2014/019, FPA2017-84756-C4]; Severo Ochoa, Spain [SEV-2014-0398]; E.C. FEDER, Spain funds, This study is supported by the Swedish Research Council, Sweden (contract number VR 2014-6644), the Scientific and Technological Research Council of Turkey (TUBITAK Project No: 117F114 and 114F473), the Polish National Science Centre, Poland, grants nos. 2017/25/B/ST2/01569 and 2016/22/M/ST2/00269 COPIN-IN2P3 and COPIGAL projects, Poland, the UK STFC under grant nos. (ST/J000124/1, ST/L005727/1, STL005735/1, ST/P003885/1), the Generalitat Valenciana and MICIU, Spain, grants PROMETEO II/2014/019, FPA2017-84756-C4, Severo Ochoa, Spain SEV-2014-0398 and by the E.C. FEDER, Spain funds.

Published
2019

19. Nuclear translocation of MRTFA in MCF7 breast cancer cells shifts ERα nuclear/genomic to extra-nuclear/non genomic actions

Author

Coralie Fontaine, Pascale Le Goff, Michael Primig, Noureddine Boujrad, Gilles Flouriot, Jean-François Arnal, Farzad Pakdel, Charly Jehanno, Denis Michel, Frédéric Percevault, Raphaël Métivier, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University Hospital Basel [Basel], Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut de Génétique et Développement de Rennes (IGDR), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Chard-Hutchinson, Xavier, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Ligue Nationale Contre Le Cancer, and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
0301 basic medicine, Epithelial-Mesenchymal Transition, Estrogen receptor, Breast Neoplasms, 030209 endocrinology & metabolism, [SDV.CAN]Life Sciences [q-bio]/Cancer, Proximity ligation assay, Biochemistry, PI3K, 03 medical and health sciences, P160 family coactivators, 0302 clinical medicine, Endocrinology, Breast cancer, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Humans, Molecular Biology, Transcription factor, Protein kinase B, SMRT, Nuclear receptor co-repressor 1, src, Cell Nucleus, Binding Sites, Chemistry, Estrogen Receptor alpha, NCOR1, Chromatin, Cell biology, Gene Expression Regulation, Neoplastic, MRTFA, Protein Transport, 030104 developmental biology, Cistrome, MCF-7 Cells, Trans-Activators, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Female, Estrogen receptor alpha, Endocrine resistance
Abstract

International audience; The Myocardin-related transcription factor A [MRTFA, also known as Megakaryoblastic Leukemia 1 (MKL1))] is a major actor in the epithelial to mesenchymal transition (EMT). We have previously shown that activation and nuclear accumulation of MRTFA mediate endocrine resistance of estrogen receptor alpha (ERα) positive breast cancers by initiating a partial transition from luminal to basal-like phenotype and impairing ERα cistrome and transcriptome. In the present study, we deepen our understanding of the mechanism by monitoring functional changes in the receptor’s activity. We demonstrate that MRTFA nuclear accumulation down-regulates the expression of the unliganded (Apo-)ERα and causes a redistribution of the protein localization from its normal nuclear place to the entire cell volume. This phenomenon is accompanied by a shift in Apo-ERα monomer/dimer ratio towards the monomeric state, leading to significant functional consequences on ERα activities. In particular, the association of Apo-ERα with chromatin is drastically decreased, and the remaining ERα binding sites are substantially less enriched in ERE motifs than in control conditions. Monitored by proximity Ligation Assay, ERα interactions with P160 family coactivators are partly impacted when MRTFA accumulates in the nucleus, and those with SMRT and NCOR1 corepressors are abolished. Finally, ERα interactions with kinases such as c-src and PI3K are increased, thereby enhancing MAP Kinase and AKT activities. In conclusion, the activation and nuclear accumulation of MRTFA in ERα positive breast cancer cells remodels both ERα location and functions by shifting its activity from nuclear genome regulation to extra-nuclear non-genomic signaling.

Published
2021

22. A New Artificial Intelligence-Based Strategy for Digital Marketing Reinforcement

Author

Yasser el Mazoui Nadori lamlili and Mouna Boujrad

Subjects
Service (systems architecture), Digital marketing, Human intelligence, Process (engineering), business.industry, Computer science, Data classification, Big data, Anomaly detection, Artificial intelligence, business, Consumer behaviour
Abstract

The success of any economy strategy is relying on the well understanding of the flow of data generated during transactions, consultations, and feedback on multiple levels, and using different tools and techniques to process and analyze this data and helps in decision making to either improve productivity and provide a customer’s service responses that fit their expectation or create a personalized profile to target a specific range of customers for specific products or services. In recent years Artificial Intelligence as an emergent technology has become a key driver in the success of many domains such as healthcare, security, industry and robotic, big data, and modern economy and digital marketing. Artificial Intelligence has proven its efficiency in data analysis and decision making. In this paper we present an overview of Artificial Intelligence and its applications in the modern economy and Digital marketing, based on that we propose a novel Artificial Intelligence-based strategy to improve success in digital marketing, we divide our strategy into multiple phases: Data acquisition, Data classification and processing, AI engine (presented on multiple levels: Detection level which is Anomaly detection in collected and treated data to sort and eliminate anomalous point in data that could lead to false decisions, Prediction level that relies on implementing techniques for prediction of customer behavior, pricing and Reporting level in which the engine generate graphs and report that helps in making a decision in the next phase) and the final phase making decision that includes a human factor since AI in our approach is only a tool based on multiple machine learning technique and not a replacement for the human intelligence.

Published
2021

23. Artificial neural networks for neutron/ γ discrimination in the neutron detectors of NEDA

Author

X. Fabian, G. Baulieu, L. Ducroux, O. Stézowski, A. Boujrad, E. Clément, S. Coudert, G. de France, N. Erduran, S. Ertürk, V. González, G. Jaworski, J. Nyberg, D. Ralet, E. Sanchis, R. Wadsworth, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nuclear and High Energy Physics, [formula omitted]-ray spectroscopy, Neutron detector, Computer Science::Neural and Evolutionary Computation, γ -ray spectroscopy, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Coincident, 0103 physical sciences, Machine learning, Neutron detection, Waveform, Neutron, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation, ComputingMilieux_MISCELLANEOUS, Physics, Artificial neural network, Artificial neural networks, Pulse-shape discrimination, n- γ discrimination, 010308 nuclear & particles physics, business.industry, Pattern recognition, Data set, n-[formula omitted] discrimination, Feature (computer vision), n-? discrimination, AGATA, Artificial intelligence, y-ray spectroscopy, business
Abstract

Three different Artificial Neural Network architectures have been applied to perform neutron/? discrimination in NEDA based on waveform and time-of-flight information. Using the coincident ?-rays from AGATA, we have been able to measure and compare on real data the performances of the Artificial Neural Networks as classifiers. While the general performances are quite similar for the data set we used, differences, in particular related to the computing times, have been highlighted. One of the Artificial Neural Network architecture has also been found more robust to time misalignment of the waveforms. Such a feature is of great interest for online processing of waveforms. Narodowe Centrum Nauki: 2017/25/B/ST2/01569 Narodowym Centrum Nauki One of the author acknowledges support of the National Science Centre, Poland (NCN) (grant no. 2017/25/B/ST2/01569 ).

Published
2021

25. Nuclear translocation of MRTFA in MCF7 breast cancer cells shifts ERα nuclear/genomic to extra-nuclear/non genomic actions

Author

Jehanno, Charly, primary, Percevault, Frédéric, additional, Boujrad, Noureddine, additional, Le Goff, Pascale, additional, Fontaine, Coralie, additional, Arnal, Jean-François, additional, Primig, Michael, additional, Pakdel, Farzad, additional, Michel, Denis, additional, Métivier, Raphaël, additional, and Flouriot, Gilles, additional

Published
2021
Full Text
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26. The New Neutron Multiplicity Filter NEDA and Its First Physics Campaign with AGATA

Author

G. Jaworski, A. Goasduff, F.J. Egea Canet, V. Modamio, T. Hüyük, A. Triossi, M. Jastrząb, P.-A. Söderström, S.M. Carturan, A. Di Nitto, G. de Angelis, G. De France, N. Erduran, A. Gadea, M. Moszyński, J. Nyberg, M. Palacz, J. Valiente, R. Wadsworth, R. Aliaga, C. Aufranc, M. Bézard, G. Beaulieu, P. Bednarczyk, E. Bisiato, A. Boujrad, I. Burrows, E. Clément, P. Cocconi, G. Colucci, D. Conventi, M. Cordwell, S. Coudert, J.M. Deltoro, L. Ducroux, T. Dupasquier, S. Ertürk, X. Fabian, V. González, A. Gottardo, A. Grant, K. Hadyńska-Klęk, A. Illana, M.L. Jurado-Gomez, M. Kogimtzis, I. Lazarus, L. Legeard, J. Ljungvall, A. Maj, G. Pasqualato, R.M. Pérez-Vidal, A. Raggio, D. Ralet, N. Redon, F. Saillant, E. Sanchis, B. Sayğı, M. Scarcioffolo, M. Siciliano, O. Stezowski, D. Testov, M. Tripon, I. Zanon, Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Ege Üniversitesi, Jaworski, G., Goasduff, A., Egea Canet, F. J., Modamio, V., Hüyük, T., Triossi, A., Jastrząb, M., Söderström, P. -A., Carturan, S. M., Di Nitto, A., De Angelis, G., De France, G., Erduran, N., Gadea, A., Moszyński, M., Nyberg, J., Palacz, M., Valiente, J., Wadsworth, R., Aliaga, R., Aufranc, C., Bézard, M., Beaulieu, G., Bednarczyk, P., Bisiato, E., Boujrad, A., Burrows, I., Clément, E., Cocconi, P., Colucci, G., Conventi, D., Cordwell, M., Coudert, S., Deltoro, J. M., Ducroux, L., Dupasquier, T., Ertürk, S., Fabian, X., González, V., Gottardo, A., Grant, A., Hadyńska-Klęk, K., Illana, A., Jurado-Gomez, M. L., Kogimtzis, M., Lazarus, I., Legeard, L., Ljungvall, J., Maj, A., Pasqualato, G., Pérez-Vidal, R. M., Raggio, A., Ralet, D., Redon, N., Saillant, F., Sanchis, E., Sayğı, B., Scarcioffolo, M., Siciliano, M., Stezowski, O., Testov, D., Tripon, M., Zanon, I., Jaworski, G., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy, Heavy Ion Laboratory, University of Warsaw, Warszawa, Poland -- Goasduff, A., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy, Department of Physics and Astronomy, University of Padua, Padua, Italy, INFN, Division of Padua, Padua, Italy -- Egea Canet, F.J., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy, Department of Physics and Astronomy, University of Padua, Padua, Italy, INFN, Division of Padua, Padua, Italy, IFIC, CSIC University of Valencia, Paterna, Spain -- Modamio, V., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy, Department of Physics, University of Oslo, Oslo, Norway -- Hüyük, T., IFIC, CSIC University of Valencia, Paterna, Spain -- Triossi, A., Department of Physics and Astronomy, University of Padua, Padua, Italy, INFN, Division of Padua, Padua, Italy, CERN, Switzerland -- Jastrzab, M., Institute of Nuclear Physics Polish Academy of Sciences, Kraków, Poland -- Söderström, P.-A., Extreme Light Infrastructure–Nucl. Phys. (ELI–NP), Bucharest, Romania -- Carturan, S.M., Department of Physics and Astronomy, University of Padua, Padua, Italy, INFN, Division of Padua, Padua, Italy -- Di Nitto, A., Helmholtz Institute Mainz and GSI, Darmstadt, Germany -- De Angelis, G., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy -- De France, G., GANIL, CEA/DSAM and CNRS/IN2P3, Caen, France -- Erduran, N., Fac. of Eng. and Natural Sciences, Istanbul Zaim University, Istanbul, Turkey -- Gadea, A., IFIC, CSIC University of Valencia, Paterna, Spain -- Moszynski, M., National Centre for Nuclear Research, Otwock-Swierk, Poland -- Nyberg, J., Department of Physics and Astronomy, Uppsala University, Uppsala, Sweden -- Palacz, M., Heavy Ion Laboratory, University of Warsaw, Warszawa, Poland -- Valiente, J., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy -- Wadsworth, R., Department of Physics, University of York, Heslington, York, United Kingdom -- Aliaga, R., IFIC, CSIC University of Valencia, Paterna, Spain -- Aufranc, C., University of Lyon, CNRS, IN2P3, IPN Lyon, Villeurbanne, France -- Bézard, M., GANIL, CEA/DSAM and CNRS/IN2P3, Caen, France -- Beaulieu, G., University of Lyon, CNRS, IN2P3, IPN Lyon, Villeurbanne, France -- Bednarczyk, P., Institute of Nuclear Physics Polish Academy of Sciences, Kraków, Poland -- Bisiato, E., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy -- Boujrad, A., GANIL, CEA/DSAM and CNRS/IN2P3, Caen, France -- Burrows, I. -- Clément, E., GANIL, CEA/DSAM and CNRS/IN2P3, Caen, France -- Cocconi, P., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy -- Colucci, G., Department of Physics and Astronomy, University of Padua, Padua, Italy, INFN, Division of Padua, Padua, Italy -- Conventi, D., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy -- Cordwell, M. -- Coudert, S., GANIL, CEA/DSAM and CNRS/IN2P3, Caen, France -- Deltoro, J.M., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy -- Ducroux, L., University of Lyon, CNRS, IN2P3, IPN Lyon, Villeurbanne, France -- Dupasquier, T., University of Lyon, CNRS, IN2P3, IPN Lyon, Villeurbanne, France -- Ertürk, S., Department of Physics, Nigde Omer Halisdemir University, Nigde, Turkey -- Fabian, X., University of Lyon, CNRS, IN2P3, IPN Lyon, Villeurbanne, France -- González, V., Department of Electric Engineering, University of Valencia, Burjassot, Spain -- Gottardo, A., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy -- Grant, A. -- Hadynska-Klek, K., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy, Department of Physics, University of Surrey, Guildford, United Kingdom -- Illana, A., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy -- Jurado-Gomez, M.L., IFIC, CSIC University of Valencia, Paterna, Spain -- Kogimtzis, M., qTFC Daresbury Laboratory, Daresbury, Warrington, United Kingdom -- Lazarus, I., qTFC Daresbury Laboratory, Daresbury, Warrington, United Kingdom -- Legeard, L., GANIL, CEA/DSAM and CNRS/IN2P3, Caen, France -- Ljungvall, J., CSNSM, CNRS, IN2P3, University Paris-Sud, Orsay, France -- Maj, A., Institute of Nuclear Physics Polish Academy of Sciences, Kraków, Poland -- Pasqualato, G., Department of Physics and Astronomy, University of Padua, Padua, Italy, INFN, Division of Padua, Padua, Italy -- Pérez-Vidal, R.M., IFIC, CSIC University of Valencia, Paterna, Spain -- Raggio, A., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy, Department of Physics and Astronomy, University of Padua, Padua, Italy -- Ralet, D., GANIL, CEA/DSAM and CNRS/IN2P3, Caen, France -- Redon, N., University of Lyon, CNRS, IN2P3, IPN Lyon, Villeurbanne, France -- Saillant, F., GANIL, CEA/DSAM and CNRS/IN2P3, Caen, France -- Sanchis, E., Department of Electric Engineering, University of Valencia, Burjassot, Spain -- Sayğı, B., Ege University, Physics Department, Izmir, Turkey -- Scarcioffolo, M., INFN, Division of Padua, Padua, Italy -- Siciliano, M., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy -- Stezowski, O., University of Lyon, CNRS, IN2P3, IPN Lyon, Villeurbanne, France -- Testov, D., Department of Physics and Astronomy, University of Padua, Padua, Italy, INFN, Division of Padua, Padua, Italy -- Tripon, M., GANIL, CEA/DSAM and CNRS/IN2P3, Caen, France -- Zanon, I., Legnaro National Laboratories (LNL), INFN, Legnaro, Italy, and 0-Belirlenecek

Subjects
Physics, Spectrometer, 010308 nuclear & particles physics, business.industry, Astrophysics::High Energy Astrophysical Phenomena, General Physics and Astronomy, Neutron multiplicity, 01 natural sciences, 7. Clean energy, 0-Belirlenecek, Physics and Astronomy (all), Optics, Filter (video), 0103 physical sciences, AGATA, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, business, Nuclear Experiment
Abstract

Zakopane Conference on Nuclear Physics - Extremes of the Nuclear Landscape -- AUG 26-SEP 02, 2018 -- Zakopane, POLAND, WOS: 000463866500047, A new neutron multiplicity filter NEDA, after a decade of design, R&D and construction, was employed in its first physics campaign with the AGATA spectrometer. Properties and performance of the array are discussed., Swedish Research CouncilSwedish Research Council [VR 2014-6644]; Scientific and Technological Research Council of Turkey (TUBITAK project)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [117F114, 114F473]; National Science Centre, Poland (NCN) [2017/25/B/ST2/01569, 2016/22/M/ST2/00269, 2014/14/M/ST2/00738, 2013/08/M/ST2/00257]; UK STFCScience & Technology Facilities Council (STFC) [ST/J000124/1, ST/L005727/1, STL005735/1, ST/P003885/1]; Generalitat Valenciana, SpainGeneralitat Valenciana; MICIU, Spain [PROM-ETEO II/2014/019, FPA2017-84756-C4, SEV-2014-0398]; E.C. FEDER fundsEuropean Union (EU), This study was supported by the Swedish Research Council (contract number VR 2014-6644), the Scientific and Technological Research Council of Turkey (TUBITAK project Nos. 117F114 and 114F473), the National Science Centre, Poland (NCN) (grants Nos. 2017/25/B/ST2/01569, 2016/22/M/ST2/00269, 2014/14/M/ST2/00738 and 2013/08/M/ST2/00257) the UK STFC under grant Nos. ST/J000124/1, ST/L005727/1, STL005735/1, ST/P003885/1, the Generalitat Valenciana and MICIU, Spain, grants PROM-ETEO II/2014/019, FPA2017-84756-C4, Severo Ochoa SEV-2014-0398 and by the E.C. FEDER funds.1

Published
2018

27. Artificial neural networks for neutron/γ discrimination in the neutron detectors of NEDA

Author

Fabian, X., primary, Baulieu, G., additional, Ducroux, L., additional, Stézowski, O., additional, Boujrad, A., additional, Clément, E., additional, Coudert, S., additional, de France, G., additional, Erduran, N., additional, Ertürk, S., additional, González, V., additional, Jaworski, G., additional, Nyberg, J., additional, Ralet, D., additional, Sanchis, E., additional, and Wadsworth, R., additional

Published
2021
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28. MUST2: A new generation array for direct reaction studies

Author

Pollacco, E., Beaumel, D., Roussel-Chomaz, P., Atkin, E., Baron, P., Baronick, J. P., Becheva, E., Blumenfeld, Y., Boujrad, A., Drouart, A., Druillole, F., Edelbruck, P., Gelin, M., Gillibert, A., Houarner, Ch., Lapoux, V., Lavergne, L., Leberthe, G., Leterrier, L., Le Ven, V., Lugiez, F., Nalpas, L., Olivier, L., Paul, B., Raine, B., Richard, A., Rouger, M., Saillant, F., Skaza, F., Tripon, M., Vilmay, M., Wanlin, E., Wittwer, M., Gross, Carl J., editor, Nazarewicz, Witold, editor, and Rykaczewski, Krzysztof P., editor

Published
2005
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32. Precision Livestock Farming : En studie på användarvänlighet och användbarhet

Author

Behnam, Jalal and Boujrad, Ayoub

Subjects
Farmers, TAM, PLF, Ease of Use, Usefulness, External Variables, Systemvetenskap, informationssystem och informatik, Information Systems
Abstract

Livestock farms have recently experienced a significant growth in their size and this is due to the increase in animal products. This has a technical impact on farmers' daily activities. As there are more animals, it becomes more difficult for the farmers to monitor, take care of and ensure the animals are treated in a healthy manner. The purpose of this study is to examine how farmers are affected by the use of the Precision Livestock Farming (PLF) systems and how they have come to accept the technology. The study will take up an important aspect of the impact and effect of PLF. The aim of the study is to find out how farmers are affected by PLF systems in regard to Ease of Use (EOU) and Usefulness. A total of five semi-structured interviews consisting of two researchers, one product advisor, one support worker and one farmer were conducted. An observation was also conducted along with the farmer and support worker. During the interviews, the participants answered our questions regarding PLF and its EOU and Usefulness. The data was analyzed using a thematic analysis and the results showed that PLF systems are important and useful but need further EOU development. Furthermore, the results showed that the poorly designed user interfaces impact the farmers’ attitude and intention towards using the system, which also affects their attitude towards the Usefulness of the PLF systems. The research confirms the importance of including farmers under the development phase of PLF systems. Lastly, this research might be the foundation for further research on how to improve and develop a more user-friendly PLF system.

Published
2019

37. Digital Front-End Electronics for the Neutron Detector NEDA

Author

F. J. Egea Canet, C. Houarner, A. Boujrad, V. Gonzalez, M. Tripon, M. Jastrzab, A. Triossi, G. de France, A. Gadea, J. J. Valiente-Dobon, D. Barrientos, E. Sanchis, M. Blaizot, P. Bourgault, G. de Angelis, M. N. Erduran, S. Erturk, T. Huyuk, G. Jaworski, X. L. Luo, V. Modamio, M. Moszynski, A. Di Nitto, J. Nyberg, P-A. Soderstrom, M. Palacz, R. Wadsworth, Huyuk, Tayfun -- 0000-0003-0597-9767, Di Nitto, Antonio -- 0000-0002-9319-366X, Jaworski, Grzegorz -- 0000-0003-2241-0329, Triossi, Andrea -- 0000-0001-5140-9154, Gadea, Andres -- 0000-0002-4233-1970, Millan, Vicente Gonzalez -- 0000-0001-6014-2586, Jastrzab, Marcin -- 0000-0003-1457-7540, Soderstrom, Par-Anders -- 0000-0002-9504-2814, Sanchis Peris, Enrique -- 0000-0002-9689-9131, de France, Gilles -- 0000-0002-7439-1759, Barrientos, Diego -- 0000-0001-9693-2942, [Egea Canet, F. J. -- Gonzalez, V. -- Sanchis, E.] Univ Valencia, Dept Elect Engn, Escola Tecn Super Engn, Valencia, Spain -- [Houarner, C. -- Boujrad, A. -- Tripon, M. -- de France, G. -- Blaizot, M. -- Bourgault, P.] GANIL, F-14076 Caen, France -- [Jastrzab, M.] Polish Acad Sci, Niewodniczanski Inst Nucl Phys, Krakow, Poland -- [Triossi, A. -- Valiente-Dobon, J. J. -- Barrientos, D. -- de Angelis, G. -- Modamio, V.] Ist Nazl Fis Nucl, Lab Nazl Legnaro, I-35020 Padua, Italy -- [Gadea, A. -- Hueyuek, T.] Inst Fis Corpuscular CSIC UV, Valencia, Spain -- [Erduran, M. N.] Istanbul Sabahattin Zaim Univ, Fac Engn & Nat Sci, Istanbul, Turkey -- [Erturk, S.] Nigde Univ, Fen Edebiyat Falkultesi, Fiz Bolumu, Nigde, Turkey -- [Jaworski, G.] Warsaw Univ Technol, Fac Phys, Warsaw, Poland -- [Jaworski, G. -- Palacz, M.] Univ Warsaw, Heavy Ion Lab, Warsaw, Poland -- [Luo, X. L.] Natl Univ Def Technol, Dept Instrument Sci & Technol, Changsha, Hunan, Peoples R China -- [Luo, X. L. -- Nyberg, J. -- Soderstrom, P-A.] Uppsala Univ, Dept Phys & Astron, Uppsala, Sweden -- [Moszynski, M.] Natl Ctr Nucl Res, PL-05400 Otwock, Poland -- [Di Nitto, A.] Johannes Gutenberg Univ Mainz, D-55099 Mainz, Germany -- [Soderstrom, P-A.] RIKEN, Nishina Ctr, Wako, Saitama, Japan -- [Wadsworth, R.] Univ York, Dept Phys, York YO10 5DD, N Yorkshire, England, Canet, F. J. E., Houarner, C., Boujrad, A., Gonzalez, V., Tripon, M., Jastrzab, M., Triossi, A., De France, G., Gadea, A., Valiente-Dobon, J. J., Barrientos, D., Sanchis, E., Blaizot, M., Bourgault, P., De Angelis, G., Erduran, M. N., Erturk, S., Huyuk, T., Jaworski, G., Luo, X. L., Modamio, V., Moszynski, M., Di Nitto, A., Nyberg, J., Soderstrom, P. -A., Palacz, M., Wadsworth, R., Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and 0-Belirlenecek

Subjects
Nuclear and High Energy Physics, Photomultiplier, front-end electronic, Physics::Instrumentation and Detectors, computer.software_genre, Analog signal processing, Neutron detection, Electronics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Electrical and Electronic Engineering, Digital electronics, Physics, neutron-gamma discrimination, Firmware, business.industry, neutron detectors, Detector, Electrical engineering, front-end electronics, Nuclear Energy and Engineering, Digital system, AGATA, neutron detector, business, Digital systems, computer
Abstract

19th Real Time Conference (RT) -- MAY 26-30, 2014 -- Nara, JAPAN, WOS: 000356458000029, This paper presents the design of the NEDA (Neutron Detector Array) electronics, a first attempt to involve the use of digital electronics in large neutron detector arrays. Starting from the front-end modules attached to the PMTs (PhotoMultiplier Tubes) and ending up with the data processing workstations, a comprehensive electronic system capable of dealing with the acquisition and pre-processing of the neutron array is detailed. Among the electronic modules required, we emphasize the front-end analog processing, the digitalization, digital pre-processing and communications firmware, as well as the integration of the GTS (Global Trigger and Synchronization) system, already used successfully in AGATA (Advanced Gamma Tracking Array). The NEDA array will be available for measurements in 2016., Osaka Univ, Res Nucl Phys, Generalitat Valenciana, Spain [PROMETEO/2010/101]; INFN, Italy; Spanish MINECO [AIC-D-2011-0746, FPA2011-29854, FPA2012-33650]; Swedish Research Council; Scientific and Technological Research Council of Turkey (TUBITAK); UK STFC; Science and Technology Facilities Council [ST/J000124/1, ST/L005735/1, ST/L005727/1], This work was supported by the Generalitat Valenciana, Spain, under grant PROMETEO/2010/101. Some authors were supported in part by INFN, Italy, and by the Spanish MINECO under grants AIC-D-2011-0746, FPA2011-29854, and FPA2012-33650. The Swedish Research Council, the Scientific and Technological Research Council of Turkey (TUBITAK), and the UK STFC also provided support.

Published
2015

38. Vomissements associés à une stagnation pondérale et convulsions: penser à une anomalie du cycle d’urée

Author

Saloua Boujrad, Rachid Abilkacem, Aomar Agadr, and Brahim El Hasbaoui

Subjects
0301 basic medicine, vomiting, medicine.medical_specialty, Urea cycle disorder, hyperammonemia, Encephalopathy, Case Report, Gastroenterology, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Internal medicine, Medicine, Anomalie du cycle de l´urée, stagnation pondérale, business.industry, vomissement, Hyperammonemia, General Medicine, medicine.disease, 030104 developmental biology, Urea cycle, Failure to thrive, hyperammoniémie, Vomiting, Phenobarbital, medicine.symptom, business, 030217 neurology & neurosurgery, weight stagnation, medicine.drug
Abstract

Dans certaines maladies métaboliques héréditaires, les vomissements peuvent apparaître comme un symptôme étant au premier plan, en particulier les anomalies du cycle de l'urée, qui sont habituellement diagnostiqués en période néonatale ou dans l'enfance. Nous en rapportons un cas de révélation tardive par un état de mal convulsif. Nous rapportons le cas d'une patiente âgée de 13 ans, qui a été hospitalisé pour prise en charge d'un état de mal convulsif et un retard staturo-pondéral. L'interrogatoire a révélé la notion de vomissements chroniques avec des troubles du comportement, ralentissement idéomoteur et céphalées. L'examen a trouvé une ataxie. La ponction lombaire et le scanner cérébral sont normaux. Une ammoniémie nettement augmentée est mise en évidence 75 micromoles/l (11-50). La chromatographie des acides aminés dans le sang a montré une augmentation de la glutamine et de l'alanine, La chromatographie des acides aminés dans les urines a montré une augmentation des acides aminés basiques évoquant un déficit du cycle de l'urée par déficit de l'enzyme Argininosuccinate lyase. La patiente a été traité en urgence par une alimentation exclusivement glucidolipidique, et par benzoate de sodium permettant une amélioration de l'état clinique, et une reprise de poids. Les crises convulsives ont été maîtrisées par le phénobarbital. L'enquête familiale a trouvé une sœur âgée de 20 ans suivie depuis l'âge de 3 ans pour crises convulsives traité par le phénobarbital dont le bilan métabolique réalisé dans notre service a objectivé la même anomalie du cycle de l'urée que sa sœur. A tout âge, devant une encéphalopathie avec épilepsie, vomissement, stagnation pondérale et hyperammoniémie, il faut penser à un déficit du cycle de l'urée. Le diagnostic est très souvent posé lors d'un accès neuro-digestif aigue associant vomissements, troubles de conscience et/ou crises convulsives.

Published
2018

39. The New Neutron Multiplicity Filter NEDA and Its First Physics Campaign with AGATA

Author

Jaworski, G., primary, Goasduff, A., additional, Egea Canet, F.J., additional, Modamio, V., additional, Hüyük, T., additional, Triossi, A., additional, Jastrząb, M., additional, Söderström, P.-A., additional, Carturan, S.M., additional, Di Nitto, A., additional, de Angelis, G., additional, De France, G., additional, Erduran, N., additional, Gadea, A., additional, Moszyński, M., additional, Nyberg, J., additional, Palacz, M., additional, Valiente, J., additional, Wadsworth, R., additional, Aliaga, R., additional, Aufranc, C., additional, Bézard, M., additional, Beaulieu, G., additional, Bednarczyk, P., additional, Bisiato, E., additional, Boujrad, A., additional, Burrows, I., additional, Clément, E., additional, Cocconi, P., additional, Colucci, G., additional, Conventi, D., additional, Cordwell, M., additional, Coudert, S., additional, Deltoro, J.M., additional, Ducroux, L., additional, Dupasquier, T., additional, Ertürk, S., additional, Fabian, X., additional, González, V., additional, Gottardo, A., additional, Grant, A., additional, Hadyńska-Klęk, K., additional, Illana, A., additional, Jurado-Gomez, M.L., additional, Kogimtzis, M., additional, Lazarus, I., additional, Legeard, L., additional, Ljungvall, J., additional, Maj, A., additional, Pasqualato, G., additional, Pérez-Vidal, R.M., additional, Raggio, A., additional, Ralet, D., additional, Redon, N., additional, Saillant, F., additional, Sanchis, E., additional, Sayğı, B., additional, Scarcioffolo, M., additional, Siciliano, M., additional, Stezowski, O., additional, Testov, D., additional, Tripon, M., additional, and Zanon, I., additional

Published
2019
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42. Up-regulation of type II collagen gene by 17β-estradiol in articular chondrocytes involves Sp1/3, Sox-9, and estrogen receptor α

Author

Noureddine Boujrad, Benoît Porée, Karim Boumediene, Laure Maneix, Magali Demoor, Aurélie Servent, David Ollitrault, Safa Moslemi, Thomas Branly, Gilles Flouriot, Nicolas Bigot, Philippe Galéra, Microenvironnement cellulaire et pathologie (MILPAT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Interactions Cellulaires et Moléculaires, Université de Rennes (UR)-IFR98-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-IFR98-Centre National de la Recherche Scientifique (CNRS)

Subjects
Cartilage, Articular, Male, Transcriptional Activation, Sp1 Transcription Factor, Type II collagen, Estrogen receptor, Biology, Chondrocyte, Transactivation, 17-estradiol, Chondrocytes, Estrogen receptor , Osteoarthritis, Drug Discovery, medicine, Animals, Humans, Type II collagen (COL2A1) gene, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, RNA, Small Interfering, Promoter Regions, Genetic, Enhancer, Receptor, Collagen Type II, Genetics (clinical), Estrogen receptor beta, Binding Sites, Estradiol, Cartilage homeostasis, Estrogen Receptor alpha, Sox proteins, Cell Differentiation, SOX9 Transcription Factor, Sp1/Sp3, Molecular biology, Up-Regulation, Cell biology, Phenotype, Sp3 Transcription Factor, Cartilage, medicine.anatomical_structure, Molecular Medicine, Rabbits
Abstract

The existence of a link between estrogen deprivation and osteoarthritis (OA) in postmenopausal women suggests that 17β-estradiol (17β-E2) may be a modulator of cartilage homeostasis. Here, we demonstrate that 17β-E2 stimulates, via its receptor human estrogen receptor α 66 (hERα66), type II collagen expression in differentiated and dedifferentiated (reflecting the OA phenotype) articular chondrocytes. Transactivation of type II collagen gene (COL2A1) by ligand-independent transactivation domain (AF-1) of hERα66 was mediated by "GC" binding sites of the -266/-63-bp promoter, through physical interactions between ERα, Sp1/Sp3, Sox9, and p300, as demonstrated in chromatin immunoprecipitation (ChIP) and Re-Chromatin Immuno-Precipitation (Re-ChIP) assays in primary and dedifferentiated cells. 17β-E2 and hERα66 increased the DNA-binding activities of Sp1/Sp3 and Sox-9 to both COL2A1 promoter and enhancer regions. Besides, Sp1, Sp3, and Sox-9 small interfering RNAs (siRNAs) prevented hERα66-induced transactivation of COL2A1, suggesting that these factors and their respective cis-regions are required for hERα66-mediated COL2A1 up-regulation. Our results highlight the genomic pathway by which 17β-E2 and hERα66 modulate Sp1/Sp3 heteromer binding activity and simultaneously participate in the recruitment of the essential factors Sox-9 and p300 involved respectively in the chondrocyte-differentiated status and COL2A1 transcriptional activation. These novel findings could therefore be attractive for tissue engineering of cartilage in OA, by the fact that 17β-E2 could promote chondrocyte redifferentiation.17β-E2 up-regulates type II collagen gene expression in articular chondrocytes. An ERα66/Sp1/Sp3/Sox-9/p300 protein complex mediates this stimulatory effect. This heteromeric complex interacts and binds to Col2a1 promoter and enhancer in vivo. Our findings highlight a new regulatory mechanism for 17β-E2 action in chondrocytes. 17β-E2 might be an attractive candidate for cartilage engineering applications.

Published
2014

43. SIRIUS is a state-of-the-art detector system for nuclear decay spectroscopy that will be mounted at the focalplane of S3 (Super Separator Spectrometer), which is part of the new SPIRAL2 facility at GANIL, Caen in France. Such a systemrequires high performance as it is dedicated to the study of very exotic nuclei. It is the result of collaboration between GANILCSNSM, IRFU, and IPHC It is composed of a succession of detectors (Trackers, Silicon detector DSSD and Tunnel plus anarray of five clover Germanium detectors). This set-up is mounted in a compact geometry. The energy measurement variesfrom 50 keV to over 500 MeV with high precision (2 x 10-3) at low energies and 1 % for the detection of heavy ions. A majorchallenge has been the development of new electronics with a very large dynamic range maintaining an adequate energyresolution for the measured particles (with energies from a few hundred keV up to 500 MeV)

Author

Karkour, N., Sulignano, B., Piot, J., Savajols, H., Drouart, A., Authier, M., Alaphilippe, V., Boujrad, A., Brionnet, P., Chaminade, Th., Coudert, S., Dechery, F., Delagnes, E., Dorvaux, O., Gall, B., Gibelin, L., Goeltzenlichter, T., Hauschild, K., Herlant, S., Lafay, X., Le Blanc, F., Lebertre, G., Lefrou, Th., Legeard, L., Linget, D., Lutton, F., Lopez-Martens, A., Mathieu, C., Maugeais, C., Moudden, Y., Pancin, J., Saillant, F., Spitaels, Ch., Theisen, Ch., Tripon, M., Wittwer, G., Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics::Instrumentation and Detectors, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Nuclear Experiment
Abstract

International audience; SIRIUS is a state-of-the-art detector system for nuclear decay spectroscopy that will be mounted at the focal plane of S$^3$ (Super Separator Spectrometer), which is part of the new SPIRAL2 facility at GANIL, Caen in France. Such a systemrequires high performance as it is dedicated to the study of very exotic nuclei. It is the result of collaboration between GANILCSNSM, IRFU, and IPHC It is composed of a succession of detectors (Trackers, Silicon detector DSSD and Tunnel plus anarray of five clover Germanium detectors). This set-up is mounted in a compact geometry. The energy measurement variesfrom 50 keV to over 500 MeV with high precision (2 x 10$^{-3}$) at low energies and 1 % for the detection of heavy ions. A majorchallenge has been the development of new electronics with a very large dynamic range maintaining an adequate energyresolution for the measured particles (with energies from a few hundred keV up to 500 MeV).

Published
2016

44. SIRIUS project (spectroscopy & identification of rare isotopes using S3)

Author

N. Karkour, Ch. Theisen, Y. Moudden, K. Hauschild, G. Lebertre, B. Gall, X. Lafay, S. Coudert, H. Savagols, A. Lopez-Martens, D. Linget, A. Boujrad, F. Dechery, B. Sulignano, P. Brionnet, J. Piot, F. Saillant, F. Le Blanc, T. Goeltzenlichter, L. Gibelin, G. Wittwer, M. Tripon, M. Authier, Th. Lefrou, O. Dorvaux, V. Alaphilippe, A. Drouart, C. Maugeais, S. Herlant, Ch. Spitaels, J. Pancin, F. Lutton, E. Delagnes, L. Legeard, C. Mathieu, and Th. Chaminade

Subjects
Physics, Silicon, Spectrometer, Physics::Instrumentation and Detectors, Preamplifier, Detector, chemistry.chemical_element, 020206 networking & telecommunications, Germanium, 02 engineering and technology, 7. Clean energy, 030218 nuclear medicine & medical imaging, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, Cardinal point, chemistry, 0202 electrical engineering, electronic engineering, information engineering, Nuclear Experiment, Spectroscopy, Radioactive decay
Abstract

SIRIUS is a state-of-the-art detector system for nuclear decay spectroscopy that will be mounted at the focal plane of S3 (Super Separator Spectrometer), which is part of the new SPIRAL2 facility at GANIL, Caen in France. Such a system requires high performance as it is dedicated to the study of very exotic nuclei. It is the result of collaboration between GANIL CSNSM, IRFU, and IPHC It is composed of a succession of detectors (Trackers, Silicon detector DSSD and Tunnel plus an array of five clover Germanium detectors). This set-up is mounted in a compact geometry. The energy measurement varies from 50 keV to over 500 MeV with high precision (2 × 10−3) at low energies and 1 % for the detection of heavy ions. A major challenge has been the development of new electronics with a very large dynamic range maintaining an adequate energy resolution for the measured particles (with energies from a few hundred keV up to 500 MeV).

Published
2016

45. A New Front-End High-Resolution Sampling Board for the New-Generation Electronics of EXOGAM2 and NEDA Detectors

Author

M. N. Erduran, Johan Nyberg, X.L. Luo, M. Jastrzab, Diego Barrientos, M. Palacz, V. Modamio, G. de Angelis, P-A Soderstrom, Vicente González, M. Moszynski, A. Boujrad, P. Bourgault, C. Houarner, M. Blaizot, A. Di Nitto, G. Jaworski, F.J. Egea, José-María Blasco, A. Triossi, M. Tripon, J. J. Valiente-Dobón, A. Gadea, T. Hüyük, S. Erturk, R. Wadsworth, Enrique Sanchis, Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Egea Canet, F. J., Gonzalez, V., Tripon, M., Jastrzab, M., Triossi, A., Gadea, A., De France, G., Valiente-Dobon, J. J., Barrientos, D., Sanchis, E., Boujrad, A., Houarner, C., Blaizot, M., Bourgault, P., De Angelis, G., Erduran, M. N., Erturk, S., Huyuk, T., Jaworski, G., Luo, X. L., Modamio, V., Moszynski, M., Di Nitto, A., Nyberg, J., Soderstrom, P. -A., Palacz, M., and Wadsworth, R.

Subjects
Physics, Nuclear and High Energy Physics, Spectrometer, Physics::Instrumentation and Detectors, Detector, Bandwidth (signal processing), Acquisition in HP-Ge detectors, high-speed ADCs, Front and back ends, high-speed ADC, Effective number of bits, Acquisition in HP-Ge detector, Nuclear Energy and Engineering, low-noise electronics design, Electronic engineering, Neutron detection, Neutron, Electronics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Electrical and Electronic Engineering
Abstract

19th Real Time Conference (RT) -- MAY 26-30, 2014 -- Nara, JAPAN WOS: 000356458000028 This paper presents the final design and results of the FADC Mezzanine for the EXOGAM (EXOtic GAMma array spectrometer) and NEDA (Neutron Detector Array) detectors. The measurements performed include those of studying the effective number of bits, the energy resolution using HP-Ge detectors, as well as timing histograms and discrimination performance. Finally, the conclusion shows how a common digitizing device has been integrated in the experimental environment of two very different detectors which combine both low-noise acquisition and fast sampling rates. Not only the integration fulfilled the expected specifications on both systems, but it also showed how a study of synergy between detectors could lead to the reduction of resources and time by applying a common strategy. Osaka Univ, Res Nucl Phys Generalitat Valenciana, Spain [PROMETEO/2010/101]; INFN, Italy; Spanish MINECO [AIC-D-2011-0746, FPA2011-29854, FPA2012-33650]; Swedish Research Council; Scientific and Technological Research Council of Turkey (TUBITAK); UK STFC; Science and Technology Facilities Council [ST/L005735/1, ST/J000124/1, ST/L005727/1] This work was supported by the Generalitat Valenciana, Spain, under grant PROMETEO/2010/101. Some authors were supported in part by INFN, Italy, and by the Spanish MINECO under grants AIC-D-2011-0746, FPA2011-29854 and FPA2012-33650. This work was also supported by the Swedish Research Council, the Scientific and Technological Research Council of Turkey (TUBITAK) and the UK STFC.

Published
2015

47. A new front-end high-resolution sampling board for the new-generation electronics of EXOGAM2 and NEDA detectors

Author

F.J. Egea, V. Gonzalez, M. Tripon, M. Jastrzab, A. Triossi, A. Gadea, G. de France, J.J. Valiente-Dobon, J.M. Blasco, D. Barrientos, E. Sanchis, A. Boujrad, C. Houarner, M. Blaizot, P. Bourgault, G. de Angelis, M.N. Erduran, S. Erturk, T. Huyuk, G. Jaworski, X.L. Luo, V. Modamio, M. Moszynski, A. Di Nitto, J. Nyberg, P-A. Soderstrom, M. Palacz, R. Wadsworth, Triossi, Andrea -- 0000-0001-5140-9154, Di Nitto, Antonio -- 0000-0002-9319-366X, Huyuk, Tayfun -- 0000-0003-0597-9767, and [Egea, F. J. -- Gonzalez, V. -- Sanchis, E.] Univ Valencia, Dept Elect Engn, Escola Tecn Super Engn, Burjassot, Valencia, Spain -- [Gadea, A. -- Barrientos, D. -- Huyuk, T.] Inst Fis Corpuscular CSIC UV, Valencia, Spain -- [Tripon, M. -- de France, G. -- Boujrad, A. -- Houarner, C. -- Blaizot, M. -- Bourgault, P.] GANIL, F-14706 Caen, France -- [Jastrzab, M.] Polish Acad Sci, Niewodniczanski Inst Nucl Phys, Krakow, Poland -- [Triossi, A. -- Valiente-Dobon, J. J. -- Barrientos, D. -- de Angelis, G. -- Modamio, V.] Ist Nazl Fis Nucl, Lab Nazl Legnaro, IT-35020 Padua, Italy -- [Jaworski, G.] Warsaw Univ Technol, Fac Phys, Warsaw, Poland -- [Jaworski, G. -- Moszynski, M. -- Palacz, M.] Univ Warsaw, Heavy Ion Lab, Warsaw, Poland -- [Luo, X. L. -- Nyberg, J. -- Soderstrom, P-A.] Uppsala Univ, Dept Phys & Astron, Uppsala, Sweden -- [Moszynski, M.] Natl Ctr Nucl Res, PL-05400 Otwock, Poland -- [Luo, X. L.] Natl Univ Def Technol, Dept Instrument Sci & Technol, Changsha, Hunan, Peoples R China -- [Soderstrom, P-A.] RIKEN Nishina Ctr, Wako, Saitama, Japan -- [Di Nitto, A.] Johannes Gutenberg Univ Mainz, D-55099 Mainz, Germany -- [Erduran, M. N.] Istanbul Sabahattin Zaim Univ, Fac Engn & Nat Sci, Istanbul, Turkey -- [Erturk, S.] Nigde Univ, Fen Edebiyat Falkultesi, Fiz Bolumu, Nigde, Turkey -- [Wadsworth, R.] Univ York, Dept Phys, York, N Yorkshire, England

Abstract

19th IEEE-NPSS Real Time Conference (RT) -- MAY 26-30, 2014 -- Nara, JAPAN, WOS: 000380588000136, The present paper aims to present the final design and results of the FADC Mezzanine for EXOGAM and NEDA detectors, focusing on the resolution performance. Finally, the conclusion shows how a common digitizing device has been integrated in an experimental environment involving low-noise and fast sampling rates. Not only the integration fulfilled the expected specifications on both systems, but also, it shows how a study of synergy between detectors has led to a reduction of resources and time by applying a common strategy., Osaka Univ, Res Nucl Phys, IEEE Nucl & Plasma Sci Soc

Published
2014

48. A digital on-line implementation of a Pulse-Shape analysis algorithm for neutron-gamma discrimination in the NEDA detector

Author

Egea, Francisco Javier, Houarner, Charles, González, Vicente, Söderström, Pär-Anders, Nyberg, Johan, Tripon, Michel, Boujrad, Abderrahman, Gadea, Andres, Jastrząb, Marcin, Valiente-Dobón, Jose Javier, France, Gilles De, Lazarus, Ian, Jaworski, G., Hüyük, Tayfun, Luo, X. L., Erduran, Mustafa Nizamettin, Ertürk, Sefa, Moszyńksi, M., Modamio, M., Palacz, M., Sanchis, E., and Wadsworth, R.

Subjects
Pulse-Shape Analysis Algorithm, Neutron-gamma Discrimination, NEDA Detector
Abstract

20th IEEE Real Time Conference, 5–10 Haz 2016, Padova, Italy -- F.J. Egea is with INFN Sezione di Padova, Padova, Italy. E-mail: javiegea@pd.infn.it. -- V. González and E. Sanchis are with Departament d’Enginyeria Electrònica. Universitat de València. Burjassot (Spain). -- C. Houarner, A. Boujrad, M. Tripon and G. de France are with Grand Accélératéur National d’Ions Lourds (GANIL), Caen, France. -- A. Gadea and T. Hüyük are with Institut de Física Corpuscular (IFIC), Paterna, Spain. -- J.J. Valiente-Dobón and G. Jaworski are with LNL (Laboratori Nazionali di Legnaro), Legnaro, Italy. -- J. Nyberg is with Department of Physics and Astronomy, Uppsala University, Uppsala, Sweden. -- M. Moszyński is with National Centre for Nuclear Research, A. Soltana 7, PL 05-400 Otwock-Swierk, Poland. -- M.N. Enduran is with Faculty of Engineering and Natural Sciences, Istanbul Sabahattin Zaim University Istanbul, Turkey. -- S. Ertürk is with Nigde Universitesi, Fen-Edebiyat Falkultesi, Fizik Bölümü, Nigde, Turkey. -- M. Jastrząb is with the Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences, Kraków, Poland. -- I. Lazarus is with STFC Daresbury Laboratory, Warrington, United Kingdom. -- P-A. Söderström is with RIKEN Nishina Center, Wako-shi, Japan. -- V. Modamio is with Universitet I Oslo, Oslo, Norway. -- X. L. Luo is with Department of Instrument Science and Technology, National University of Defense Technology, Changsha, China. -- M.Palacz are with the Heavy Ion Laboratory, University of Warsaw, Warszawa, Poland. -- R. Wadsworth is with Department of Physics, University of York, York, United Kingdom. The detection of rare events close to the proton dripline involve the utilization of high-efficient neutron detectors with excellent neutron-gamma discrimination (NGD) performance. Even though in the literature, several off-line algorithms focus on the maximization of the NGD accuracy, our aim is to look for an on-line efficient implementation capable to discard a majority of the gamma-rays, therefore allowing the system to work to counting rates up to 50 kHz, optimizing hence the overall electronics infrastructure in terms of data throughput. In this paper we analyze two of the most widespread techniques for NGD based on PSA, i.e. the charge-comparison method (CC) and the zero crossover (ZCO). Then, based on the NGD performance and FPGA resource utilization, we select one to be implemented in an FPGA. Finally we present the preliminary results obtained up to now.

Published
2016

49. Several synthetic progestins disrupt the glial cell specific-brain aromatase expression in developing zebra fish

Author

Elisabeth Pellegrini, Joel Cano-Nicolau, Farzad Pakdel, Clémentine Garoche, Olivier Kah, Nathalie Hinfray, Noureddine Boujrad, François Brion, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut National de l'Environnement Industriel et des Risques (INERIS), ANR PROOFS 'Occurrences and effects of environmental ligands of progesterone receptor on fish reproduction and neuro-development' [ANR-13-CESA-0006-03], ANR PROOFS, French Ministry of Ecology ('Axe de Recherche Ecotoxicologie') [P190], Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), ANR-13-CESA-0006,PROOFS,Occurrence et effets de ligands environnementaux des récepteurs de la progestérone sur la reproduction et le neurodéveloppement du poisson(2013), and Chard-Hutchinson, Xavier

Subjects
0301 basic medicine, long-term exposure, stickleback gasterosteus-aculeatus, Estrogen receptor, 010501 environmental sciences, Toxicology, 01 natural sciences, Animals, Genetically Modified, adversely affect reproduction, Testosterone, Aromatase, Zebrafish, [SDV.TOX.ECO] Life Sciences [q-bio]/Toxicology/Ecotoxicology, biology, Estradiol, Progesterone Congeners, Brain, 3. Good health, adult zebrafish, medicine.anatomical_structure, Receptors, Estrogen, Androgens, Neuroglia, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology, aquatic environment, medicine.medical_specialty, animal structures, Green Fluorescent Proteins, endocrine disrupters, 03 medical and health sciences, Internal medicine, Cell Line, Tumor, Progesterone receptor, medicine, Animals, Humans, Luciferase, 0105 earth and related environmental sciences, Pharmacology, Estrogens, Zebrafish Proteins, biology.organism_classification, gene-expression, Radial glial cell, danio-rerio, 030104 developmental biology, Endocrinology, environmental concentrations, biology.protein, estrogen-receptors
Abstract

International audience; The effects of some progestins on fish reproduction have been recently reported revealing the hazard of this class of steroidal pharmaceuticals. However, their effects at the central nervous system level have been poorly studied until now. Notwithstanding, progesterone, although still widely considered primarily a sex hormone, is an important agent affecting many central nervous system functions. Herein, we investigated the effects of a large set of synthetic ligands of the nuclear progesterone receptor on the glial-specific expression of the zebrafish brain aromatase (cyp19a1b) using zebrafish mechanism-based assays. Progesterone and 24 progestins were first screened on transgenic cyp19a1b-GFP zebrafish embryos. We showed that progesterone, dydrogesterone, drospirenone and all the progesterone-derived progestins had no effect on GFP expression. Conversely, all progestins derived from 19-nortesterone induced GFP in a concentration-dependent manner with EC50 ranging from the low nM range to hundreds nM. The 19-nortestosterone derived progestins levonorgestrel (LNG) and norethindrone (NET) were further tested in a radial glial cell context using U251-MG cells co-transfected with zebrafish ER subtypes (zfER alpha, zfER beta 1 or zfER beta 2) and cyp19a1b promoter linked to luciferase. Progesterone had no effect on luciferase activity while NET and LNG induced luciferase activity that was blocked by ICI 182,780. Zebrafish-ERs competition assays showed that NET and LNG were unable to bind to ERs, suggesting that the effects of these compounds on cyp19a1b require metabolic activation prior to elicit estrogenic activity. Overall, we demonstrate that 19-nortestosterone derived progestins elicit estrogenic activity by inducing cyp19a1b expression in radial glial cells. Given the crucial role of radial glial cells and neuro-estrogens in early development of brain, the consequences of exposure of fish to these compounds require further investigation.

Published
2016

50. Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis

Author

Mathieu Baritaud, Hanan Boujrad, Hans K. Lorenzo, Slavica Krantic, and Santos A. Susin

Subjects
medicine.medical_specialty, medicine.medical_treatment, Apoptosis, Nutrient sensing, Biology, Energy homeostasis, Histones, Cyclophilins, Necrosis, Insulin resistance, Internal medicine, Diabetes mellitus, medicine, Humans, Molecular Biology, bcl-2-Associated X Protein, Neuropeptide Gene, Calpain, Insulin, Apoptosis Inducing Factor, Type 2 Diabetes Mellitus, Cell Biology, medicine.disease, Insulin receptor, Endocrinology, Caspases, biology.protein, Developmental Biology
Abstract

Caspase-independent programmed necrosis is a highly regulated cellular demise that displays morphological and biochemical necrotic hallmarks, such as an earlier permeability of the plasma membrane and lactate dehydrogenase (LDH) leakiness. This form of programmed cell death (PCD) is regulated by AIF, a FAD-dependent oxidoreductase, which is released from the mitochondria to the nucleus where it induces chromatin tcondensation and DNA fragmentation. Some years ago, it was established that the sequential activation of poly(ADP-ribose) polymerase- 1 (PARP-1), calpains and Bax regulates the mitochondrial AIF release associated to programmed necrosis. But, what happens when AIF is in the nucleus? How does this protein induce chromatinolysis and programmed necrosis? Recently, we have unraveled some of the mechanisms underlying the nuclear action of AIF in this type of caspase-independent cell death. Indeed, AIF plays a key role in programmed necrosis by its ability to organize a DNA-degrading complex with H2AX and Cyclophiline A (CypA). The AIF/H2AX link is indeed a critical event and explains the nuclear AIF apoptogenic action. In the present article, we outline the current knowledge on cell death by programmed necrosis and discuss the relevance of the AIF/H2AX/CypA DNA-degrading complex in the regulation of this original form of cell death.

Published
2010

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