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1. Endogenous ether lipids differentially promote tumor aggressiveness by regulating the SK3 channel

Author

Papin, Marion, Fontaine, Delphine, Goupille, Caroline, Figiel, Sandy, Domingo, Isabelle, Pinault, Michelle, Guimaraes, Cyrille, Guyon, Nina, Cartron, Pierre François, Emond, Patrick, Lefevre, Antoine, Gueguinou, Maxime, Crottès, David, Jaffrès, Paul-Alain, Ouldamer, Lobna, Maheo, Karine, Fromont, Gaëlle, Potier-Cartereau, Marie, Bougnoux, Philippe, Chantôme, Aurélie, and Vandier, Christophe

Published
2024
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5. Data from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases

Author

Chantôme, Aurélie, primary, Potier-Cartereau, Marie, primary, Clarysse, Lucie, primary, Fromont, Gaëlle, primary, Marionneau-Lambot, Séverine, primary, Guéguinou, Maxime, primary, Pagès, Jean-Christophe, primary, Collin, Christine, primary, Oullier, Thibauld, primary, Girault, Alban, primary, Arbion, Flavie, primary, Haelters, Jean-Pierre, primary, Jaffrès, Paul-Alain, primary, Pinault, Michelle, primary, Besson, Pierre, primary, Joulin, Virginie, primary, Bougnoux, Philippe, primary, and Vandier, Christophe, primary

Published
2023
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6. Supplementary Methods from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases

Author

Chantôme, Aurélie, primary, Potier-Cartereau, Marie, primary, Clarysse, Lucie, primary, Fromont, Gaëlle, primary, Marionneau-Lambot, Séverine, primary, Guéguinou, Maxime, primary, Pagès, Jean-Christophe, primary, Collin, Christine, primary, Oullier, Thibauld, primary, Girault, Alban, primary, Arbion, Flavie, primary, Haelters, Jean-Pierre, primary, Jaffrès, Paul-Alain, primary, Pinault, Michelle, primary, Besson, Pierre, primary, Joulin, Virginie, primary, Bougnoux, Philippe, primary, and Vandier, Christophe, primary

Published
2023
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7. Supplementary Figures 1 - 5 from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases

Author

Chantôme, Aurélie, primary, Potier-Cartereau, Marie, primary, Clarysse, Lucie, primary, Fromont, Gaëlle, primary, Marionneau-Lambot, Séverine, primary, Guéguinou, Maxime, primary, Pagès, Jean-Christophe, primary, Collin, Christine, primary, Oullier, Thibauld, primary, Girault, Alban, primary, Arbion, Flavie, primary, Haelters, Jean-Pierre, primary, Jaffrès, Paul-Alain, primary, Pinault, Michelle, primary, Besson, Pierre, primary, Joulin, Virginie, primary, Bougnoux, Philippe, primary, and Vandier, Christophe, primary

Published
2023
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8. Use of [18F]-FDG PET to predict response to neoadjuvant trastuzumab and docetaxel in patients with HER2-positive breast cancer, and addition of bevacizumab to neoadjuvant trastuzumab and docetaxel in [18F]-FDG PET-predicted non-responders (AVATAXHER): an open-label, randomised phase 2 trial

Author

Coudert, Bruno, Pierga, Jean-Yves, Mouret-Reynier, Marie-Ange, Kerrou, Kaldoun, Ferrero, Jean-Marc, Petit, Thierry, Kerbrat, Pierre, Dupré, Pierre-François, Bachelot, Thomas, Gabelle, Philippe, Giard, Sylvia, Coeffic, David, Bougnoux, Philippe, Prevost, Jean-Briac, Paintaud, Gilles, Thibault, Gilles, Hernandez, Juana, Coudert, Mathieu, Arnould, Laurent, and Berriolo-Riedinger, Alina

Published
2014
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9. N-3 Fatty Acid Supplementation Impacts Protein Metabolism Faster Than it Lowers Proinflammatory Cytokines in Advanced Breast Cancer Patients: Natural 15N/14N Variations during a Clinical Trial

Author

Mantha, Olivier L., primary, Hankard, Régis, additional, Tea, Illa, additional, Schiphorst, Anne-Marie, additional, Dumas, Jean-François, additional, Berger, Virginie, additional, Goupille, Caroline, additional, Bougnoux, Philippe, additional, and De Luca, Arnaud, additional

Published
2022
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13. Dénutrition cancéreuse et inflammation : effet des acides gras polyinsaturés n-3

Author

Dumas Jean-François, Couet Charles, Bougnoux Philippe, and Servais Stéphane

Subjects
cachexia, cytokines, metabolism, mitochondria, Oils, fats, and waxes, TP670-699
Abstract

Undernutrition is frequently seen in cancer and is considered as a bad prognostic factor. The mechanisms involved in this complex syndrome are not fully understood. Systemic inflammation plays an important role in the occurrence and/or development of cancer-associated undernutrition. Although it is essential to counteract cancer-associated undernutrition, modalities for nutritional treatment are still discussed. It has been shown that nutritional supplementation with n-3 polyunsaturated fatty acid could be beneficial in patients.

Published
2011
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14. Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study

Author

Cortes, Javier, O'Shaughnessy, Joyce, Loesch, David, Blum, Joanne L, Vahdat, Linda T, Petrakova, Katarina, Chollet, Philippe, Manikas, Alexey, Diéras, Veronique, Delozier, Thierry, Vladimirov, Vladimir, Cardoso, Fatima, Koh, Han, Bougnoux, Philippe, Dutcus, Corina E, Seegobin, Seth, Mir, Denis, Meneses, Nicole, Wanders, Jantien, and Twelves, Chris

Published
2011
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17. N-3 Fatty Acid Supplementation Impacts Protein Metabolism Faster Than it Lowers Proinflammatory Cytokines in Advanced Breast Cancer Patients: Natural 15 N/ 14 N Variations during a Clinical Trial.

Author

Mantha, Olivier L., Hankard, Régis, Tea, Illa, Schiphorst, Anne-Marie, Dumas, Jean-François, Berger, Virginie, Goupille, Caroline, Bougnoux, Philippe, and De Luca, Arnaud

Subjects
OMEGA-3 fatty acids, METASTATIC breast cancer, PROTEIN metabolism, CANCER patients, CLINICAL trials
Abstract

While clinical evidence remains limited, an extensive amount of research suggests a beneficial role of n-3 polyunsaturated fatty acid supplementation in cancer treatment. One potential benefit is an improvement of protein homeostasis, but how protein metabolism depends on proinflammatory cytokines in this context remains unclear. Here, using the natural abundance of the stable isotopes of nitrogen as a marker of changes in protein metabolism during a randomized, double-blind, controlled clinical trial, we show that protein homeostasis is affected way faster than proinflammatory cytokines in metastatic breast cancer patients supplemented with n-3 polyunsaturated fatty acids. We provide some evidence that this response is unrelated to major changes in whole-body substrate oxidation. In addition, we demonstrate that more fatty acids were impacted by metabolic regulations than by differences in their intake levels during the supplementation. This study documents that the percentage of patients that complied with the supplementation decreased with time, making compliance assessment crucial for the kinetic analysis of the metabolic and inflammatory responses. Our results highlight the time-dependent nature of metabolic and inflammatory changes during long-chain n-3 fatty acid supplementation. [ABSTRACT FROM AUTHOR]

Published
2022
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19. ASPECTS NUTRITIONNELS DES ACIDES GRAS POLYINSATURES n-3 Augmentation sélective de la sensibilité des tumeurs à la chimiothérapie par les acides gras polyinsaturés n-3

Author

Bougnoux Philippe, Poncheville Loïc de, Germain Emmanuelle, Cognault Sophie, Montharu Jérôme, Aubourg Lucie, Bonnet Pierre, and Chajes Véronique

Subjects
n-3 PUFA, docosahexaenoic acid, mammary tumors, chemosensitivity, breast cancer, anthracyclins, Oils, fats, and waxes, TP670-699
Abstract

L’alimentation intervient à différents niveaux dans le déroulement de la maladie cancéreuse : au niveau du risque [1] et au niveau de l’évolution en modifiant le risque de survenue des métastases. L’alimentation influence-t-elle aussi la réponse aux traitements anticancéreux ? À l’appui de cette hypothèse viennent deux observations indirectes réalisées dans le cancer du sein : nos données [2, 3] ainsi que les observations épidémiologiques provenant d’autres travaux [4] ont apporté des arguments supportant l’hypothèse que les lipides alimentaires peuvent influencer la réponse des tumeurs mammaires aux traitements. On sait que la composition des lipides membranaires n’est pas génétiquement déterminée, mais qu’elle dépend des acides gras disponibles aux tissus périphériques. Le type d’acides gras disponibles est influencé par les apports alimentaires. Comme les tumeurs incorporent dans leurs lipides les acides gras disponibles de façon similaire aux autres tissus [5], il est plausible que les habitudes alimentaires (apports alimentaires en acides gras polyinsaturés, vitamines anti ou pro-oxydantes) puissent influencer leur chimiosensibilité en apportant aux cellules tumorales des substrats de peroxydation.

Published
2000
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20. Acide alpha-linolénique, anti-oxydants et croissance tumorale mammaire

Author

Chajes Véronique, Cognault Sophie, Maillard Virginie, Pinault Michelle, Jourdan Marie-Lise, Lhuillery Claude, and Bougnoux Philippe

Subjects
breast cancer, n-3 polyunsaturated fatty acids, antioxidant, Oils, fats, and waxes, TP670-699
Abstract

En France, comme dans la plupart des pays occidentaux, le cancer du sein est la première cause de mortalité, avec un nombre annuel de décès proche de 10 000. Chez les femmes, le cancer du sein est celui dont le taux d’incidence est le plus élevé dans la plupart des pays occidentaux. En France, il y a approximativement 35 000 nouveaux cas chaque année. Le taux d’incidence est de 80 pour 100 000 femmes/an. Il existe une disparité géographique dans les taux d’incidence du cancer du sein. Ils sont élevés dans tous les pays développés, à l’exception du Japon et de la Chine. Ajusté sur l’âge, il est le plus élevé aux États-Unis, et le plus bas en Chine, en Inde, au Japon. La France se situe à une position intermédiaire en Europe. L’incidence du cancer du sein est globalement plus faible dans les pays du Sud de l’Europe. Cette disparité géographique ne peut pas être expliquée uniquement par les facteurs génétiques. L’étude des populations migrantes, dont les taux d’incidence du cancer du sein se modifient pour atteindre celui du pays dans lequel elles migrent, a permis de mettre en évidence le rôle des facteurs environnementaux dans l’apparition du cancer du sein. Parmi ceux-là, la part de l’alimentation est estimée à environ 35 % (entre 20 à 60 %, en fonction du site du cancer) [1]. Il existe donc un réel potentiel de prévention du cancer du sein, sous réserve que les aliments protecteurs soient mis en évidence et que les nutriments responsables de ces effets protecteurs soient individualisés.

Published
2000
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21. Synthetic alkyl-ether-lipid promotes TRPV2 channel trafficking trough PI3K/Akt-girdin axis in cancer cells and increases mammary tumour volume

Author

Guéguinou, Maxime, primary, Felix, Romain, additional, Marionneau-Lambot, Séverine, additional, Oullier, Thibauld, additional, Penna, Aubin, additional, Kouba, Sana, additional, Gambade, Audrey, additional, Fourbon, Yann, additional, Ternant, David, additional, Arnoult, Christophe, additional, Simon, Gaëlle, additional, Bouchet, Ana Maria, additional, Chantôme, Aurélie, additional, Harnois, Thomas, additional, Haelters, Jean-Pierre, additional, Jaffrès, Paul-Alain, additional, Weber, Gunther, additional, Bougnoux, Philippe, additional, Carreaux, François, additional, Mignen, Olivier, additional, Vandier, Christophe, additional, and Potier-Cartereau, Marie, additional

Published
2021
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27. Low Levels of Omega-3 Long-Chain Polyunsaturated Fatty Acids Are Associated with Bone Metastasis Formation in Premenopausal Women with Breast Cancer: A Retrospective Study

Author

Goupille, Caroline, primary, Frank, Philippe G., additional, Arbion, Flavie, additional, Jourdan, Marie-Lise, additional, Guimaraes, Cyrille, additional, Pinault, Michelle, additional, Body, Gilles, additional, Chevalier, Stephan, additional, Bougnoux, Philippe, additional, and Ouldamer, Lobna, additional

Published
2020
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42. Na(+)-H(+) antiporter activity in relation to membrane fatty acid composition and cell proliferation

Author

Gore, Jacques, Besson, Pierre, Hoinard, Claude, and Bougnoux, Philippe

Subjects
Essential fatty acids -- Research, Breast cancer -- Research, Cell proliferation -- Analysis, Biological sciences
Abstract

Na(+)-H(+) antiporter activation is not a component of the mechanism involved in MCF7 human breast cancer cell line proliferation. The Na(+)-H(+) antiporter enables pH maintenance at neutral or slightly basic values in the MCF7 cells. The antiporter is reversible and affected by changes in extracellular Na(+) levels. Cell proliferation decreases when the essential fatty acid levels in the growth medium are altered, while intracellular pH and intracellular buffering capacity remain unaffected.

Published
1994

44. Conservative treatment feasibility with induction chemotherapy, surgery, and radiotherapy for patients with breast carcinoma larger than 3 cm

Author

Calais, Gilles, Berger, Christine, Descamps, Philippe, Chapet, Sophie, Reynaud-Bougnoux, Agnes, Body, Gilles, Bougnoux, Philippe, Lansac, Jacques, and Le Floch, Olivier

Subjects
Breast cancer -- Care and treatment, Radiotherapy -- Usage, Chemotherapy -- Usage, Lumpectomy -- Usage, Health
Abstract

Background. The traditional surgical treatment for operable breast carcinoma larger than 3 cm is mastectomy. To avoid mutilating surgery, the authors administered primary chemotherapy to 158 patients with operable nonmetastatic large breast carcinoma with a TNM classification of T2 greater than 3 cm and T3 with a lymph node status of N0-N1. Conservative treatment was proposed for patients responding to the chemotherapy and whose tumor was reduced to 3 cm or less. The purpose of the study was to evaluate the feasibility and treatment results of this strategy. Methods. The mean patient age was 50.4 years. Eighty-two patients had T2 carcinomas greater than 3 cm, and 76 had T3 carcinoma. Fifty-four tumors were classified as lymph node status N0, and 104 as N1. Mean tumor size was 5.6 cm. Patients were treated with three courses of the NVCF regimen (mitoxantrone, vindesin, cyclophosphamide, and 5-fluorouracil) or the EVCF regimen, in which mitoxantrone was replaced by epirubicin every 4 weeks, and then administered with a radiosurgical combination. Results. The overall response rate to induction chemotherapy was 60.8% with 20.2% complete tumor regression. Twenty-one percent of the patients experienced grade 3 or 4 chemotherapy toxic effects, which were all acceptable and reversible. Breast-conserving treatment was feasible in 48.7% of patients (77 of 158). Forty-five patients (28.5%) were treated with a radiosurgical combination tumorectomy plus radiation therapy), whereas 32 20.2%1 were treated with radiotherapy alone (external irradiation and brachytherapy). Other patients were treated with mastectomy. Age, tumor stage. histology, hormonal status, and hormonal receptor rate had no influence on the frequency of the observed regressions. Isolated recurrences occurred in 11 patients, 6 who were treated conservatively and 5 who were treated with mastectomy. Metastatic relapses were observed in 38 patients (14.6% in the chemotherapy responders and 38.7% in the nonresponders) (P < 0.02). Five-year actuarial survival was 73.2% and was significantly higher for responders to the induction treatment. Conclusion. These preliminary results suggest that primary chemotherapy and radiosurgical breast-conserving treatment is feasible and is an alternative to mastectomy for patients with large operable breast carcinoma who are responders to the induction treatment. The long term benefit of this strategy must be evaluated in well designed controlled trials. Cancer 1994; 74:1283-8. Key words: breast carcinoma, induction chemotherapy, conservative treatment, locally advanced tumors.

Published
1994

45. Dependence of human milk essential fatty acids on adipose stores during lactation

Author

Martin, Jean-Charles, Bougnoux, Philippe, Fignon, Alain, Theret, Veronique, Antoine, Jean-Michel, Lamisse, Fernand, and Couet, Charles

Subjects
Breast milk -- Health aspects, Essential fatty acids in human nutrition -- Health aspects, Adipose tissues -- Health aspects, Food/cooking/nutrition, Health
Abstract

The relationships between essential fatty acid (EFA) composition of colostrum, mature milk, and white adipose tissue (WAT) were examined on days 5 and 30 postpartum in 24 healthy French mothers. Fatty acid composition was assessed by capillary gas chromatography. In WAT, the proportion of individual polyunsaturated fatty acids (PUFAs) did not change during lactation and was greater (18:2n-6) or lower (18:3n-3, long-chain PUFAs) than values found in colostrum or mature milk (P < 0.04). The 18:2n-6 content and the ratio of 18:3n-3 to 18:2n-6 correlated between WAT and colostrum (r = 0.52 and r = 0.57, respectively) or mature milk (r = 0.64 and r = 0.65, respectively). These relationships agree with an expected qualitative effect of WAT fatty acid composition on interindividual variability of milk parent EFA content. The decrease in the long-chain PUFA content observed from colostrum to mature milk and the concomitant occurrence of a precursor-product relationship between the linoleate and its long-chain PUFA are consistent with the mobilization of a preformed long-chain PUFA pool during early lactation.

Published
1993

48. Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Martin, Miguel, primary, Holmes, Frankie A, additional, Ejlertsen, Bent, additional, Delaloge, Suzette, additional, Moy, Beverly, additional, Iwata, Hiroji, additional, von Minckwitz, Gunter, additional, Chia, Stephen K L, additional, Mansi, Janine, additional, Barrios, Carlos H, additional, Gnant, Michael, additional, Tomašević, Zorica, additional, Denduluri, Neelima, additional, Šeparović, Robert, additional, Gokmen, Erhan, additional, Bashford, Anna, additional, Ruiz Borrego, Manuel, additional, Kim, Sung-Bae, additional, Jakobsen, Erik Hugger, additional, Ciceniene, Audrone, additional, Inoue, Kenichi, additional, Overkamp, Friedrich, additional, Heijns, Joan B, additional, Armstrong, Anne C, additional, Link, John S, additional, Joy, Anil Abraham, additional, Bryce, Richard, additional, Wong, Alvin, additional, Moran, Susan, additional, Yao, Bin, additional, Xu, Feng, additional, Auerbach, Alan, additional, Buyse, Marc, additional, Chan, Arlene, additional, Harvey, Vernon, additional, Tomek, Rudolf, additional, Robert, Nicholas J., additional, Gore, Ira, additional, Smith, John W., additional, Masuda, Norikazu, additional, Di Sean Kendall, S., additional, Harker, William Graydon, additional, Petrakova, Katarina, additional, Guerrero Zotano, Angel, additional, Simon, Amparo Ruiz, additional, Konstantinovic, Zora Neskovic, additional, Iannotti, Nicholas O., additional, Tassone, Pierfrancesco, additional, Rodriguez, Gladys I., additional, Jáñez Martinez, Noelia, additional, Crespo Massieu, Carmen, additional, Smickoska, Snezana, additional, Somali, Isil, additional, Yilmaz, Ugur, additional, Alonso, Mirta Garcia, additional, Rosales, Adolfo Murias, additional, Cold, Soeren, additional, Knoop, Ann Soegaard, additional, Patt, Debra, additional, Hellerstedt, Beth A., additional, Morales Murillo, Serafin, additional, Mayer, Ingrid A., additional, Means-Powell, Julie Ann, additional, Hui, Rina, additional, Senecal, Francis M., additional, De Boer, Richard Hendry, additional, Shen, Zhenzhou, additional, Luczak, Adam Andrzej, additional, Chui, Joanna W.Y., additional, Tsang, Janice Wing-hang, additional, Lang, Istvan, additional, Rai, Yoshiaki, additional, Hozumi, Yasuo, additional, Ten Tije, Albert J., additional, Bhandari, Manish, additional, Osborne, Cynthia R.C., additional, Ohtani, Shoichiro, additional, Higaki, Kenji, additional, Watanabe, Kenichi, additional, Taguchi, Kazunori, additional, Takahashi, Masato, additional, Filipovic, Sladjana, additional, Hansen, Vincent L., additional, Rao, Vijayarama Phooshkooru, additional, Gupta, Manish, additional, Petrov, Petar, additional, Coudert, Bruno, additional, Vojnovic, Zeljko, additional, Polya, Zsofia, additional, Miyaki, Toshiko, additional, Yamamoto, Naohito, additional, Brincat, Stephen, additional, Lesniewski-Kmak, Krzysztof, additional, Chmielowska, Ewa, additional, Birhiray, Ruemu E., additional, Citron, Marc L., additional, Papish, Steven William, additional, Berry, William R., additional, Langkjer, Sven Tyge, additional, Garcia Sáenz, José Angel, additional, Arance, Ana Maria, additional, Efrat, Noa, additional, Sarosiek, Tomasz, additional, Grzeda, Lukasz, additional, Manalo, Yvonne, additional, Smith, Julie C., additional, Vaziri, Irfan, additional, Healey, Tabitha, additional, Rahim, Yasmin, additional, Luk, Cynthia, additional, Dingle, Brian, additional, Franco, Sandra, additional, Sorensen, Peter Grundtvig, additional, Anand, Anjana, additional, Khan, Sarah, additional, Fountzilas, George, additional, Aogi, Kenjiro, additional, Shimizu, Satoru, additional, Mikulova, Milada, additional, Spanik, Stanislav, additional, Somer, Robert A., additional, Flynn, Patrick J., additional, Coward, Jermaine, additional, Mainwaring, Paul, additional, Jerusalem, Guy, additional, Segura-Ojezzar, Carine, additional, Levy, Christelle, additional, Delozier, Thierry, additional, Khayat, David, additional, Coleman, Robert E., additional, Rolles, Martin J., additional, Maisano, Robert, additional, Nardi, Mario, additional, Ito, Yoshinori, additional, Yumuk, Perran Fulden, additional, Basaran, Gul, additional, Serdar Turhal, Nazim, additional, Wilkinson, Mary J., additional, Green, Nathan B., additional, Sidrys, Algis P., additional, Hallmeyer, Sigrun, additional, Testori, Douglas J., additional, Sridhar, Srikala, additional, Chang, Jose, additional, Sun, Qiang, additional, Jara-Sanchez, Carlos, additional, Rubio, Xabier, additional, Garrido, Maria Lomas, additional, De La Haba Rodriguez, Juan Rafael, additional, Perello Martorell, Antonia, additional, Avelia Mestre, Antoni, additional, Rifa Ferrer, Julio, additional, del Barco Berron, Sonia, additional, Nagy, Zsuzsanna, additional, Tanaka, Maki, additional, Im, Young-Hyuck, additional, Carroll, Robert R., additional, Dickerson, Laura C., additional, Mace, Joseph R., additional, Rivera, Ragene, additional, Klein, Leonard M., additional, Ruxer, Robert, additional, Wilks, Sharon T., additional, Kotasek, Dusan, additional, Popov, Vasil, additional, Taskova, Violina, additional, Marinova-Venkova, Violetka, additional, Timcheva, Constanta, additional, Desbiens, Christine, additional, Ayoub, Jean-Pierre, additional, Grenier, Debjani, additional, Marschner, Norbert, additional, Tesch, Hans, additional, Lueck, Hans-Joachim, additional, Janssen, Jan, additional, Schwaner, Ingo, additional, Wahlstrom, Stine, additional, Brix, Eva Harder, additional, Vallentin, Susanne, additional, Kristensen, Dan, additional, Andreeva, Anna, additional, Glavicic, Vesna, additional, Calvo Plaza, Isabel, additional, Anton Torres, Antonio, additional, Veyret, Corinne, additional, Bergerat, Jean-Pierre, additional, Bourbouloux, Emmanuelle, additional, Ella, Wendy Ann, additional, Algurafi, Hafiz, additional, Robinson, Anne, additional, Kim, Seung Jin, additional, Taguchi, Tetsuya, additional, Juozaityte, Elona, additional, Madretsma, Stanley, additional, Radema, Sandra, additional, Czerniawska-Meier, Malgorzata, additional, Rogowski, Wojciech, additional, Wagnerova, Maria, additional, Richards, Donald A., additional, Tan-Chiu, Elizabeth, additional, Vasileios, Asskikis, additional, Henderson, Charles Arthur, additional, Holden, Viran Roger, additional, Wang, Xiaojia, additional, Tong, Zhongsheng, additional, Yang, Junlan, additional, Gonzalez, Manuel Enrique, additional, Rezai, Mahdi, additional, Hackmann, John, additional, de Dueñas, Eduardo Martinez, additional, de las Heras, Begoña Bermejo, additional, Dourthe, Louis Marie, additional, Chocteau-Bouju, Dorothee, additional, Bougnoux, Philippe, additional, Kakolyris, Stylianos, additional, Kalofonos, Haralabos, additional, Pectasidis, Dimitrios, additional, Ng, Ting Ying, additional, Pajkos, Gabor, additional, Somogyine, Eva Ezer, additional, Tonini, Giuseppe, additional, Giuffrida, Dario, additional, Takao, Shintaro, additional, Ishitobi, Makoto, additional, Inaji, Hideo, additional, Tokuda, Yutaka, additional, Wozniak, Katarzyna, additional, Lungulescu, Dan, additional, Lu, Yen-Shen, additional, Chang, King-Jen, additional, Hill, Julian, additional, Croot, Christopher Charles, additional, Dekker, Albert, additional, Belman, Neil D., additional, Conde, Miguel, additional, Michaelson, Richard A., additional, Kemmer, Kathleen, additional, Chui, Stephen, additional, Luoh, Shiuh-Wen, additional, Nahum, Kenneth, additional, Greenspan, Andrew R., additional, Nichols, Joni C., additional, Encarnacion, Carlos A., additional, Niederman, Thomas M.J., additional, Lee, Theresa, additional, Alexander, Roland, additional, Gordon, Robert, additional, Tomova, Antoanet, additional, Rauch, Daniel, additional, Popescu, Razvan Andrei, additional, Rojas, Gustavo Adolfo, additional, Vanasek, Jaroslav, additional, Neunhoeffer, Tanja, additional, Barinoff, Jana, additional, Graffunder, Gerd, additional, Wolfgang, Abenhardt, additional, Bojko, Peter, additional, Heinrich, Bernhard, additional, von der Assen, Albert, additional, Antonovic, Bogovic Jurij, additional, Adrian, Lene, additional, Ramos Vazquez, Manuel, additional, Gonzalez Santiago, Santiago, additional, Dieras, Veronique, additional, Bishop, Jill Mercia, additional, Perren, Timothy John, additional, Varthalitis, Ioannis, additional, Mavroudis, Dimitris, additional, Georgoulias, Vassilis, additional, Chow, Louis W.C., additional, Yau, Chung Cheung Thomas, additional, Liang, Raymond Hin-Suen, additional, Pikó, Béla, additional, Wéber, Agnes, additional, Kaufman, Bella, additional, Drumea, Karen, additional, Nuzzo, Francesco, additional, De Matteis, Andrea, additional, Carteni, Giacomo, additional, Tokunaga, Eriko, additional, Ishida, Mayumi, additional, Ohno, Shinji, additional, Sato, Nobuaki, additional, Kuroi, Katsumasa, additional, Nishimura, Reiki, additional, Watanabe, Junichiro, additional, Choi, Yoon Ji, additional, Park, Kyong Hwa, additional, Wojtukiewicz, Marek, additional, Jassem, Jacek, additional, Loman, Niklas, additional, Askoy, Sercan, additional, Altundag, Mustafa Kadri, additional, Saip, Pinar, additional, Ali, Muhammad Amjad, additional, Wade, James Lloyd, additional, Chien, Amy Jo, additional, Brandt, Debra, additional, Novik, Yelena, additional, Jani, Chirag, additional, Rice, Robert L., additional, Gaffar, Yousuf A. R, additional, Keaton, Mark R., additional, Bajaj, Rajesh, additional, Kimmick, Gretchen, additional, Campbell, David, additional, Turnquest, Theodore, additional, Lucas, Sideras, additional, Dube, Pierre, additional, Xu, Binghe, additional, Schilling, Joerg, additional, Apel, Klaus, additional, Vestlev, Peter Michael, additional, Jensen, Brita Bjerregaard, additional, Haahr, Vera, additional, Lescure, Alvaro Rodriguez, additional, Grana Suarez, Begona, additional, Saura Manich, Cristina, additional, Jacquin, Jean-Philippe, additional, Samreen, Ahmed, additional, Boiangiu, Ion, additional, Dank, Magdolna, additional, Falci, Cristina, additional, Jirillo, Antonio, additional, Cinieri, Saverio, additional, Ueno, Takayuki, additional, Sato, Fumiaki, additional, Yamashiro, Hiroyasu, additional, Sugie, Tomoharu, additional, Lee, Keun Seok, additional, Ro, Jung Sil, additional, Park, In Hae, additional, Bustam, Anita Zarina, additional, Suszko-Kazarnowicz, Malgorzata, additional, Piktel, Artur, additional, Krzemieniecki, Krzysztof, additional, Iorga, Polizenia Georgeta, additional, Yap, Yoon Sim, additional, Kakalejcik, Marian, additional, Sevinc, Alper, additional, Ozguroglu, Mustafa, additional, Chen, Shin-Cheh, additional, Greenberg, Richard H., additional, Eisemann, Allan Daniel, additional, Droder, Robert, additional, Abbasi, M. 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Published
2017
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49. Polyunsaturated Fatty Acids of Marine Origin and Multifocality in Human Breast Cancer

Author

Ouldamer, Lobna, Goupille, Caroline, Vildé, Anne, Arbion, Flavie, Body, Gilles, Chevalier, Stéphan, Cottier, Jean-Philippe, Bougnoux, Philippe, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Nutrition, croissance et cancer (U 1069) (N2C), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Radiology, Université Jean Monnet [Saint-Étienne] (UJM), Service d'Anatomopathologie [Tours], Department of Gynecology, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Goupille, Caroline, Université Jean Monnet - Saint-Étienne (UJM), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), and Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV] Life Sciences [q-bio], [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV]Life Sciences [q-bio], [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, skin and connective tissue diseases, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

International audience; Objective The microenvironment of breast epithelial tissue may contribute to the clinical expression of breast cancer. Breast epithelial tissue, whether healthy or tumoral, is directly in contact with fat cells, which in turn could influence tumor multifocality. In this pilot study we investigated whether the fatty acid composition of breast adipose tissue differed according to breast cancer focality. Methods Twenty-three consecutive women presenting with non-metastatic breast cancer underwent breast-imaging procedures including Magnetic Resonance Imaging prior to treatment. Breast adipose tissue specimens were collected during breast surgery. We established a biochemical profile of adipose tissue fatty acids by gas chromatography. We assessed whether there were differences according to breast cancer focality. Results We found that decreased levels in breast adipose tissue of docosahexaenoic and eicosa-pentaenoic acids, the two main polyunsaturated n-3 fatty acids of marine origin, were associated with multifocality. Discussion These differences in lipid content may contribute to mechanisms through which peritumoral adipose tissue fuels breast cancer multifocality.

Published
2016

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