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13 results on '"Boudarene, Lydia"'

1. “As a woman who watches how my family is… I take the difficult decisions”: a qualitative study on integrated family planning and childhood immunisation services in five African countries

Author

Hoyt, Jenna, Krishnaratne, Shari, Hamon, Jessie K., Boudarene, Lydia, Chantler, Tracey, Demissie, Shiferaw Dechasa, Landegger, Justine, Moseti, Easterlina, Marcus, Seth, Kambanje, Misozi, Pryor, Shannon, Spilotros, Nathaly, Gnintoungbe, Marius, Curry, Dora, and Webster, Jayne

Published
2021
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2. Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus.

Author

Izeddin, Ignacio, Récamier, Vincent, Bosanac, Lana, Cissé, Ibrahim I, Boudarene, Lydia, Dugast-Darzacq, Claire, Proux, Florence, Bénichou, Olivier, Voituriez, Raphaël, Bensaude, Olivier, Dahan, Maxime, and Darzacq, Xavier

Subjects
Cell Line, Tumor, Cell Nucleus, Humans, Proto-Oncogene Proteins c-myc, Luminescent Proteins, Green Fluorescent Proteins, Histones, Transcription Factors, Positive Transcriptional Elongation Factor B, biophysics, cell biology, human, nuclear organization, single-molecule tracking, structural biology, target search, transcription regulation, Cell Line, Tumor, Biochemistry and Cell Biology
Abstract

Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role of nuclear architecture. We implemented a single-molecule tracking assay to determine TFs dynamics. We found that c-Myc is a global explorer of the nucleus. In contrast, the positive transcription elongation factor P-TEFb is a local explorer that oversamples its environment. Consequently, each c-Myc molecule is equally available for all nuclear sites while P-TEFb reaches its targets in a position-dependent manner. Our observations are consistent with a model in which the exploration geometry of TFs is restrained by their interactions with nuclear structures and not by exclusion. The geometry-controlled kinetics of TFs target-search illustrates the influence of nuclear architecture on gene regulation, and has strong implications on how proteins react in the nucleus and how their function can be regulated in space and time.

Published
2014

5. Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders

Author

Chaste, Pauline, Clement, Nathalie, Botros, Hany Goubran, Guillaume, Jean-Luc, Konyukh, Marina, Pagan, Cécile, Scheid, Isabelle, Nygren, Gudrun, Anckarsäter, Henrik, Rastam, Maria, Ståhlberg, Ola, Gillberg, Carina I., Melke, Jonas, Delorme, Richard, Leblond, Claire, Toro, Roberto, Huguet, Guillaume, Fauchereau, Fabien, Durand, Christelle, Boudarene, Lydia, Serrano, Emilie, Lemière, Nathalie, Launay, Jean Marie, Leboyer, Marion, Jockers, Ralf, Gillberg, Christopher, and Bourgeron, Thomas

Published
2011
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6. Prevalence of Hepatitis B Virus (HBV) Basal Core Promoter/Precore region molecular variants among HIV/HBV co-infected and HBV mono-infected patients in Ile-Ife, Nigeria

Author

Osasona, Oluwadamilola Gideon, primary, Boudarene, Lydia, additional, Adewale-Fasoro, Opeoluwa, additional, George, Uwem, additional, Oguzie, Judith, additional, Ariyo, Olumuyiwa Elijah, additional, Olumade, Testimony J., additional, Adeniyi, Awe, additional, Adewumi, Moses Olubusuyi, additional, and Adeniji, Adekunle Johnson, additional

Published
2020
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7. Genetic and Functional ascertainment of the Melatonin Pathway in Patients with Attention Deficit and Hyperactivity Disorders

Author

Chaste, Pauline, Clement, Nathalie, Botros, Hany, Guillaume, Jean-Luc, Konyukh, Marina, Pagan, Cécile, Scheid, Isabelle, Nygren, Gudrun, Anckarsäter, Henrik, Råstam, Maria, Ståhlberg, Ola, Gillberg, I. Carina, Melke, Jonas, Delorme, Richard, Leblond, Claire, Toro, Roberto, Huguet, Guillaume, Fauchereau, Fabien, Durand, Christelle, Boudarene, Lydia, Serrano, Emilie, Lemière, Nathalie, Launay, Jean Marie, Leboyer, Marion, Jockers, Ralf, Gillberg, Christopher, Bourgeron, Thomas, Génétique Humaine et Fonctions Cognitives, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Cochin (UMR_S567 / UMR 8104), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Göteborgs Universitet (GU), Lund University [Lund], AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut fédératif de Recherche Lariboisière (IFR_139), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Fondation FondaMental [Créteil], This work was supported by the Institut Pasteur, Université Paris Diderot, INSERM, CNRS, FP6 ENI‐NET, Fondation FondaMental and Fondation pour la Recherche Médicale (‘Equipe FRM’, RJ)., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), and Toro, Roberto

Subjects
[SDV] Life Sciences [q-bio], ASMT, [SDV]Life Sciences [q-bio], AA-NAT, ADHD, receptors, melatonin, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], genes
Abstract

Sleep wake cycles are frequently disturbed in patients with Attention Deficit and Hyperactivity Disorders. We hypothesized that the origin of the sleep problems may be the consequence of an abnormal circadian clock setting regulated by the melatonin pathway. Here, we sequenced all the genes of the melatonin pathway AA-NAT, ASMT, MTNR1A, MTNR1B and GPR50 in 328 individuals from Sweden including 108 patients with ADHD and 220 from the general population. Non-synonymous mutations were identified in all genes at a similar frequency in patients with ADHD and in controls. Among the functional variations, a splice site mutation (IVS5+2T>C) in ASMT and one stop mutation (Y170X) in MTNR1A were only detected in patients with ADHD. Biochemical analyses indicated that these mutations abolish the activity of ASMT and MTNR1A. We also identified clusters of SNPs within MTNR1B showing significant difference in the allelic frequency between ADHD patients and control (maximum signal at rs10830961 P=0.0002). Taken together, these genetic and functional results shed light on one new compelling candidate pathway for susceptibility to circadian rhythms alterations that could help clinicians for providing better treatments of patients with ADHD and sleep problems.

Published
2018

9. Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

Author

Massachusetts Institute of Technology. Department of Physics, Cisse, Ibrahim, Izeddin, Ignacio, Recamier, Vincent, Bosanac, Lana, Boudarene, Lydia, Dugast-Darzacq, Claire, Proux, Florence, Benichou, Olivier, Voituriez, Raphaël, Bensaude, Olivier, Dahan, Maxime, Darzacq, Xavier, Massachusetts Institute of Technology. Department of Physics, Cisse, Ibrahim, Izeddin, Ignacio, Recamier, Vincent, Bosanac, Lana, Boudarene, Lydia, Dugast-Darzacq, Claire, Proux, Florence, Benichou, Olivier, Voituriez, Raphaël, Bensaude, Olivier, Dahan, Maxime, and Darzacq, Xavier

Abstract

Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role of nuclear architecture. We implemented a single-molecule tracking assay to determine TFs dynamics. We found that c-Myc is a global explorer of the nucleus. In contrast, the positive transcription elongation factor P-TEFb is a local explorer that oversamples its environment. Consequently, each c-Myc molecule is equally available for all nuclear sites while P-TEFb reaches its targets in a position-dependent manner. Our observations are consistent with a model in which the exploration geometry of TFs is restrained by their interactions with nuclear structures and not by exclusion. The geometry-controlled kinetics of TFs target-search illustrates the influence of nuclear architecture on gene regulation, and has strong implications on how proteins react in the nucleus and how their function can be regulated in space and time., Nikon France (Research contract), France. Agence nationale de la recherche (PCV DYNAFT 08-PCVI-0013), France. Agence nationale de la recherche (DynamIC ANR-12-BSV5-0018), Fondation pour la recherche médicale, Netherlands Organization for Scientific Research (Rubicon fellowship)

Published
2014

10. Author response: Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

Author

Izeddin, Ignacio, primary, Récamier, Vincent, additional, Bosanac, Lana, additional, Cissé, Ibrahim I, additional, Boudarene, Lydia, additional, Dugast-Darzacq, Claire, additional, Proux, Florence, additional, Bénichou, Olivier, additional, Voituriez, Raphaël, additional, Bensaude, Olivier, additional, Dahan, Maxime, additional, and Darzacq, Xavier, additional

Published
2014
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