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5. Summaries of the papers of the 4th National Congress of the Tunisian Society of Medical Oncology attached to the 4th Maghreb Congress of Oncology

Author

Abbes, I., Abdelhak, S., Abdelhedi, C., Abid, K., Abidi, R., Acacha, E., Achour, S., Achour, A., Adouni, O., Afrit, M., Ahlem, A., Akik, I., Akremi, M., Aloui, R., Aloulou, S., Ammar, N., Arem, S., Athimni, S., Attia, L., Attia, M., Ayadi, M., Ayadi, A., Ayadi, K., Ayadi, H., Ayadi, L., Ayadi, I., Ayari, J., Azzouz, H., Bacha, D., Bahloul, R., Bahri, I., Bahri, M., Bakir, D., Balti, M., Bargaoui, H., Batti, R., Bayar, R., Bdioui Thabet, A., Beji, M., Bel Hadj Hassen, S., Bel Haj Ali, A., Belaid, I., Belaid, A., Beldjiilali, Y., Belkacem, O., Bellamlih, O., Ben Abdallah, W., Ben Abdallah, M., Ben Abdellah, H., Ben Abderrahmen, S., Ben Ahmed, S., Ben Ahmed, K., Ben Ayache, M., Ben Ayoub, W., Ben Azaiz, M., Ben Azouz, M., Ben Daly, A., Ben Dhia, S., Ben Dhiab, M., Ben Dhiab, T., Ben Fatma, L., Ben Ghachem, D., Ben Hammadi, S., Ben Hassen, M., Ben Hassena, R., Ben Hassouna, J., Ben Kridis, W., Ben Leila, F., Ben Mahfoudh, K. H., Ben Mustapha, N., Ben Nasr, S., Ben Othman, F., Ben Rejeb, M., Ben Rekaya, M., Sami BenRhouma, Ben Safta, Z., Ben Safta, I., Ben Said, A., Ben Salah, M., Ben Salah, H., Ben Slama, S., Ben Temime, R., Ben Youssef, Y., Ben Zid, K., Benabdella, H., Benasr, S., Bengueddach, A., Benna, M., Benna, F., Bergaoui, H., Berrazaga, Y., Besbes, M., Bhiri, H., Bibi, M., Blel, A., Bohli, M., Bouali, S., Bouaouina, N., Bouassida, K., Bouaziz, H., Boubaker, J., Boudaouara, T., Boudaouara, Z., Boudaouara, O., Boughanmi, F., Boughattas, W., Boughizane, S., Bouguila, H., Bouhani, M., Bouhlel, B., Boujelbane, N., Boujemaa, M., Boulma, R., Bouraoui, S., Bouriga, R., Bourmech, M., Bousrih, C., Boussen, H., Boussen, N., Bouzaien, F., Bouzayene, F., Brahem, I., Briki, R., Chaabene, K., Chaabouni, M., Chaari, H., Chabchoub, I., Chachia, S., Chaker, K., Chamlali, M., Charfi, L., Charfi, M., Charfi, S., Charradi, H., Cheffai, I., Chelly, B., Chelly, I., Chenguel, A., Cherif, A., Cherif, O., Chiboub, A., Chouchene, A., Chraiet, N., Daghfous, A., Daldoul, A., Daoud, N., Daoud, J., Daoud, R., Daoud, E., Debaibi, M., Dhaouadi, S., Dhief, R., Dhouib, F., Dimassi, S., Djebbi, A., Doghri, R., Doghri, Y., Doudech, B., Dridi, M., El Amine, O., El Benna, H., El Khal, M. C., Eladeb, M., Elloumi, M., Elmeddeb, K., Enaceur, F., Ennouri, S., Essoussi, M., Ezzairi, F., Ezzine, A., Faleh, R., Fallah, S., Faouzi, N., Fathallah, K., Fehri, R., Feki, J., Fekih, M., Fendri, S., Fessi, Z., Fourati, N., Fourati, M., Frikha, I., Frikha, M., Gabsi, A., Gadria, S., Gamoudi, A., Gargoura, A., Gargouri, W., Ghariani, N., Ghazouani, E., Ghorbal, A., Ghorbel, L., Ghorbel, S., Ghozzi, A., Glili, A., Gmadh, K., Goucha, A., Gouiaa, N., Gritli, S., Guazzah, K., Guebsi, A., Guermazi, Z., Guermazi, F., Gueryani, N., Guezguez, M., Hacheni, F., Hachicha, M., Haddad, A., Haddaoui, A., Hadoussa, M., Haj Mansour, M., Hajjaji, A., Hajji, A., Hamdi, A., Hamdi, Y., Hammemi, R., Haouet, S., Hdiji, A., Hechiche, M., Hedfi, M., Helali, A. J., Henchiri, H., Heni, S., Hentati, A., Herbegue, K., Hidar, S., Hlaf, M., Hmida, W., Hmida, I., Hmida, L., Hmila Ben Salem, I., Hochlef, M., Hsairi, M., Jaffel, H., Jaidane, M., Jarraya, H., Jebsi, M., Jedidi, M., Jlassi, A., Jlassi, H., Jmal, H., Jmour, O., Jouini, M., Kabtni, W., Kacem, M., Kacem, S., Kacem, I., Kaid, M., Kairi, H., Kallel, M., Kallel, R., Kallel, F., Kammoun, H., Kamoun, S., Kanoun Belajouza, S., Karray, W., Karrit, S., Karrou, M., Kchir, N., Kdous, S., Kehili, H., Keskes, H., Khairi, H., Khalfallah, M. T., Khalifa, M. B., Khanfir, A., Khanfir, F., Khechine, W., Khemiri, S., Khiari, H., Khlif, A., Khouni, H., Khrouf, S., Kochbati, L., Korbi, I., Korbi, A., Krir, M. W., Ksaier, I., Ksantini, R., Ksantini, M., Ksantini, F., Ktari, K., Laabidi, S., Laamouri, B., Labidi, A., Lahmar, A., Lahouar, R., Lamine, O., Letaief, F., Limaiem, F., Limayem, I., Limem, S., Limem, F., Loghmari, A., M Ghirbi, F., Maamouri, F., Magherbi, H., Mahjoub, N., Mahjoub, M., Mahjoubi, K., Majdoub, S., Makhlouf, T., Makni, A., Makni, S., Mallat, N., Manai, M. H., Mansouri, H., Maoua, M., Marghli, I., Masmoudi, T., Mathlouthi, N., Meddeb, K., Medini, B., Mejri, N., Merdessi, A., Mesali, C., Mezlini, E., Mezlini, A., Mezni, E., Mghirbi, F., Mhiri, N., Mighri, N., Mlika, M., Mnejja, W., Mnif, H., Mokni, M., Mokrani, A., Mosbah, F., Moujahed, R., Mousli, A., Moussa, A., Mrad Dali, K., Mrizak, N., Msakni, I., Mzabi, S., Mzali, R., Mzoughi, Z., Naimi, Z., Najjar, S., Nakkouri, R., Nasr, C., Nasrallah, D., Nasri, M., Njim, L., Noubigh, G. E. F., Nouira, Y., Nouri, O., Omrani, S., Osmane, W., Ouanes, Y., Ouanna, N., Oubich, F., Oumelreit Belamlih, G., Rachdi, H., Rafraf, F., Rahal, K., Raies, H., Rammeh, S., Rebaii, N., Rekik, W., Rekik, H., Rhim, M. S., Rhim, S., Rihab, D., Rjiba, R., Rziga, T., Saad, H., Saad, A., Saadi, M., Said, N., Salah, R., Sallemi, N., Sassi, A., Sassi, K., Sassi Mahfoudh, A., Sbika, W., Sellami, A., Serghini, M., Sghaier, S., Sh Zidi, Y., Siala, W., Slimane, M., Slimani, O., Soltani, S., Souguir, M. K., Sridi, A., Tabet Zatla, A., Tajina, D., Talbi, G., Tbessi, S., Tebra Mrad, S., Temessek, H., Tlili, G., Toumi, N., Toumi, O., Toumia, N., Tounsi, H., Trigui, E., Triki, M., Triki, A., Turki, M., Werda, I., Yahyaoui, S., Yahyaoui, Y., Yaich, A., Yamouni, M., Yazid, D., Yousfi, A., Zaghouani, H., Zaied, S., Zairi, F., Zaraa, S., Zehani, A., Zenzri, Y., Zidi, A., Znaidi, N., Zouari, K., Zouari, S., Zoukar, O., and Zribi, A.

6. Trichofolliculoma: A Case Series.

Author

Massara B, Sellami K, Graja S, Boudaouara O, Miladi S, Hammami F, Bahloul E, Boudaouara T, and Turki H

Abstract

Trichofolliculoma (TF) is a rare benign adnexal follicular tumor, described as hamartoma with follicular differentiation according to some authors. It typically appears during adulthood on the face or scalp as an isolated nodule with protrusion of central tufted hairs. We present a retrospective series of eleven patients with histologically confirmed TF to evaluate epidemiological, clinical, and histopathologic characteristics. The mean age at excision was 46 years with extremes ranging from 20 to 75 years. The sex ratio M/F was 0.37. Clinical presentation was a papule or nodule with an average diameter of 6,7mm (2-15 mm), firm with central pit in 54 percent and visible emerging vellus hairs in 18 percent of cases only. The localization was on the face in seven cases (63.6%) and only four cases were located outside the face (scalp [n=2], sub mammary fold [n=1] and shoulder [n=1]). Histologically, a cystically dilated hair follicle containing keratinous material with several mature and immature branched follicular structures is described in all cases. According to our series, TF occurs predominantly in women without age predilection, in the face. Central tufted hairs are only found in a minority of cases corresponding histologically to many secondary vellus hair follicles. In fact, histopathological examination is the gold standard for the diagnosis because clinical diagnosis could be challenging. Histology and dermoscopy may vary according to the age of the lesion. To date, only few case series have been published., Competing Interests: FUNDING: No funding was provided for this article DISCLOSURES: The authors report no conflicts on interest relevant to the content of this article., (Copyright © 2023. Matrix Medical Communications. All rights reserved.)

Published
2023

7. Development and Evaluation of the Wound Healing Effect of a Novel Topical Cream Formula Based on Ginkgo biloba Extract on Wounds in Diabetic Rats.

Author

Bardaa S, Makni K, Boudaouara O, Bardaa T, Ktari N, Hachicha S, Ben Salah R, Kallel R, Sahnoun Z, and Boufi S

Subjects
Administration, Topical, Animals, Diabetes Mellitus, Experimental complications, Diabetes Mellitus, Experimental pathology, Disease Models, Animal, Male, Rats, Rats, Wistar, Skin pathology, Diabetes Mellitus, Experimental drug therapy, Ginkgo biloba chemistry, Plant Extracts pharmacology, Skin drug effects, Skin Cream pharmacology, Wound Healing drug effects
Abstract

Despite advances in diabetes care, impaired diabetic wound healing remains a significant clinical problem. The present study was aimed at developing a novel cream based on Ginkgo biloba extract and investigating its wound healing effect on full-thickness wounds in diabetic rats. The topical formulated oil-in-water emulsion-based cream contains Ginkgo biloba aqueous extract in an amount of about 1% to 5% as an active agent. The prepared formula was subjected to physicochemical assessment and pharmacotechnical characterization. Eighteen alloxan-induced diabetic rats completing full-thickness excisional skin wounds were randomly divided into three groups topically treated with either a normal saline (control group), the reference drug ("Cytol Centella cream®"), and cream based on the Ginkgo biloba extract. The response to treatment was assessed by macroscopic, qualitative, and quantitative histopathological analysis. The prepared formula showed good physicochemical properties. The rheological behavior of the prepared cream followed a non-Newtonian pseudoplastic pattern at different storage temperatures. The cream, which is a macroemulsion with uniform size distribution, remained stable for 6 months. Skin tolerance studies confirmed the compatibility of the cream with the skin. During the experimental trial, the cream based on the Ginkgo biloba -treated group showed significant improvements over the control and reference groups for both general wound appearance and healing dynamics. This increased rate of closure of wounds in diabetic rats was associated with increased collagen synthesis. Our findings showed that the cream could be a promising and innovative topical treatment with Ginkgo biloba extract for the management of acute diabetic wounds., Competing Interests: The authors declare no conflict of interest that could have influenced the work reported in this paper., (Copyright © 2021 Sana Bardaa et al.)

Published
2021
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8. [Association of thyrolipoma and thyrolipomatosis: A case report].

Author

Ayadi S, Hammami B, Boudaouara O, Boudawara T, Kallel S, and Charfeddine I

Subjects
Humans, Middle Aged, Ultrasonography, Adenoma, Goiter, Thyroid Neoplasms
Abstract

We report a rare case of thyrolipoma-thyrolipomatosis' association. A 48-year-old patient, with a past history of high blood pressure and chronic renal failure secondary to AA amyloidosis, presented with a midline neck swelling increasing in size since one year. Ultrasound showed a multinodular goiter, the worst nodule was left-lobar and categorized as EU-TIRADS 4. Grossly, cut section of the thyroïd specimen showed a yellow-tan left-lobar nodule measuring 2.5cm, the surrounding tissue had a diffuse yellow-brown appearance with scattered whitish areas. Histopathologic examination revealed that the nodule corresponded to a follicular adenoma.Thyroid fat infiltration was noticed both within the nodule and in the neighboring parenchyma. Thus, the diagnosis of an association thyrolipoma-thyrolipomatosis was rendered. The association of thyrolipoma-thyrolipomatosis is a very rare occurrence of unclear pathogenesis. To the best of our knowledge, this report describes the second case in the literature. The diagnosis is retained on the basis of certain histological features, revealing mature adipose tissue within thyroid gland as a combined nodular and diffuse pattern., (Copyright © 2020. Published by Elsevier Masson SAS.)

Published
2021
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9. Renal angiomyolipoma: Clinico-pathologic study of 17 cases with emphasis on the epithelioid histology and p53 gene abnormalities.

Author

Boudaouara O, Kallel R, Dhieb D, Smaoui W, Ayed HB, Keskes L, and Sellami Boudawara T

Subjects
Adult, Angiomyolipoma diagnosis, Angiomyolipoma pathology, Angiomyolipoma surgery, Female, Humans, Immunohistochemistry standards, Male, Middle Aged, Mutation, Missense genetics, Nephrectomy statistics & numerical data, Organ Sparing Treatments statistics & numerical data, Retrospective Studies, Severity of Illness Index, Angiomyolipoma genetics, Epithelioid Cells pathology, Genes, p53 genetics, Kidney Neoplasms pathology
Abstract

Background: Epithelioid angiomyolipoma (EAML) is a rare potentially malignant variant of renal angiomyolipoma (RAML). This study aims to determine whether RAML clinico-pathologic and molecular features (i.e. p53 gene abnormalities) differ significantly with regards to its histologic variant or to the presence of an epithelioid component within it., Methods: Consecutively resected RAML were reviewed, tumours comprising at least 80% of epithelioid cells were considered as EAML according to the 2016 World Health Organization classification of tumours of the kidney. P53 gene abnormalities were investigated using both immunohistochemical and molecular analysis., Results: A total of 3 EAML among 17 RAML were identified, accounting for 3.9% of the total AML cases. Fatty aspect on imaging was more observed within tumours devoid of an epithelioid component. EAML showed a higher mitotic rate and a stronger p53 staining, no renal poles involvement and was not treated by nephron sparing surgeries. RAML comprising an epithelioid component demonstrated severer nuclear atypia as well as stronger p53 staining. P53 gene sequencing revealed a missense mutation (c.747G > C) in one classic AML harbouring a strong labelling with p53., Conclusions: Strong p53 staining in a RAML, even in the absence of gene mutation, may suggest the presence of an epithelioid component or of a truly EAML. To the best of our knowledge, c.747G > C p53 gene mutation is being reported for the first time in a RAML, although its role in AML pathogenesis is still unknown., Competing Interests: Declaration of competing interest None., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Published
2020
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10. Summaries of the papers of the 4th National Congress of the Tunisian Society of Medical Oncology attached to the 4th Maghreb Congress of Oncology.

Author

Abbes I, Abdelhak S, Abdelhedi C, Abid K, Abidi R, Acacha E, Achour S, Achour A, Adouni O, Afrit M, Ahlem A, Akik I, Akremi M, Aloui R, Aloulou S, Ammar N, Arem S, Athimni S, Attia L, Attia M, Ayadi M, Ayadi A, Ayadi K, Ayadi H, Ayadi L, Ayadi I, Ayari J, Azzouz H, Bacha D, Bahloul R, Bahri I, Bahri M, Bakir D, Balti M, Bargaoui H, Batti R, Bayar R, Bdioui Thabet A, Beji M, Bel Hadj Hassen S, Bel Haj Ali A, Belaid I, Belaid A, Beldjiilali Y, Belkacem O, Bellamlih O, Ben Abdallah W, Ben Abdallah M, Ben Abdellah H, Ben Abderrahmen S, Ben Ahmed S, Ben Ahmed K, Ben Ayache M, Ben Ayoub W, Ben Azaiz M, Ben Azouz M, Ben Daly A, Ben Dhia S, Ben Dhiab M, Ben Dhiab T, Ben Fatma L, Ben Ghachem D, Ben Hammadi S, Ben Hassen M, Ben Hassena R, Ben Hassouna J, Ben Kridis W, Ben Leila F, Ben Mahfoudh KH, Ben Mustapha N, Ben Nasr S, Ben Othman F, Ben Rejeb M, Ben Rekaya M, Ben Rhouma S, Ben Safta Z, Ben Safta I, Ben Said A, Ben Salah M, Ben Salah H, Ben Slama S, Ben Temime R, Ben Youssef Y, Ben Zid K, Benabdella H, Benasr S, Bengueddach A, Benna M, Benna F, Bergaoui H, Berrazaga Y, Besbes M, Bhiri H, Bibi M, Blel A, Bohli M, Bouali S, Bouaouina N, Bouassida K, Bouaziz H, Boubaker J, Boudaouara T, Boudaouara Z, Boudaouara O, Boughanmi F, Boughattas W, Boughizane S, Bouguila H, Bouhani M, Bouhlel B, Boujelbane N, Boujemaa M, Boulma R, Bouraoui S, Bouriga R, Bourmech M, Bousrih C, Boussen H, Boussen N, Bouzaien F, Bouzayene F, Brahem I, Briki R, Chaabene K, Chaabouni M, Chaari H, Chabchoub I, Chachia S, Chaker K, Chamlali M, Charfi L, Charfi M, Charfi S, Charradi H, Cheffai I, Chelly B, Chelly I, Chenguel A, Cherif A, Cherif O, Chiboub A, Chouchene A, Chraiet N, Daghfous A, Daldoul A, Daoud N, Daoud J, Daoud R, Daoud E, Debaibi M, Dhaouadi S, Dhief R, Dhouib F, Dimassi S, Djebbi A, Doghri R, Doghri Y, Doudech B, Dridi M, El Amine O, El Benna H, El Khal MC, Eladeb M, Elloumi M, Elmeddeb K, Enaceur F, Ennouri S, Essoussi M, Ezzairi F, Ezzine A, Faleh R, Fallah S, Faouzi N, Fathallah K, Fehri R, Feki J, Fekih M, Fendri S, Fessi Z, Fourati N, Fourati M, Frikha I, Frikha M, Gabsi A, Gadria S, Gamoudi A, Gargoura A, Gargouri W, Ghariani N, Ghazouani E, Ghorbal A, Ghorbel L, Ghorbel S, Ghozzi A, Glili A, Gmadh K, Goucha A, Gouiaa N, Gritli S, Guazzah K, Guebsi A, Guermazi Z, Guermazi F, Gueryani N, Guezguez M, Hacheni F, Hachicha M, Haddad A, Haddaoui A, Hadoussa M, Haj Mansour M, Hajjaji A, Hajji A, Hamdi A, Hamdi Y, Hammemi R, Haouet S, Hdiji A, Hechiche M, Hedfi M, Helali AJ, Henchiri H, Heni S, Hentati A, Herbegue K, Hidar S, Hlaf M, Hmida W, Hmida I, Hmida L, Hmila Ben Salem I, Hochlef M, Hsairi M, Jaffel H, Jaidane M, Jarraya H, Jebsi M, Jedidi M, Jlassi A, Jlassi H, Jmal H, Jmour O, Jouini M, Kabtni W, Kacem M, Kacem S, Kacem I, Kaid M, Kairi H, Kallel M, Kallel R, Kallel F, Kammoun H, Kamoun S, Kanoun Belajouza S, Karray W, Karrit S, Karrou M, Kchir N, Kdous S, Kehili H, Keskes H, Khairi H, Khalfallah MT, Khalifa MB, Khanfir A, Khanfir F, Khechine W, Khemiri S, Khiari H, Khlif A, Khouni H, Khrouf S, Kochbati L, Korbi I, Korbi A, Krir MW, Ksaier I, Ksantini R, Ksantini M, Ksantini F, Ktari K, Laabidi S, Laamouri B, Labidi A, Lahmar A, Lahouar R, Lamine O, Letaief F, Limaiem F, Limayem I, Limem S, Limem F, Loghmari A, M'ghirbi F, Maamouri F, Magherbi H, Mahjoub N, Mahjoub M, Mahjoubi K, Majdoub S, Makhlouf T, Makni A, Makni S, Mallat N, Manai MH, Mansouri H, Maoua M, Marghli I, Masmoudi T, Mathlouthi N, Meddeb K, Medini B, Mejri N, Merdessi A, Mesali C, Mezlini E, Mezlini A, Mezni E, Mghirbi F, Mhiri N, Mighri N, Mlika M, Mnejja W, Mnif H, Mokni M, Mokrani A, Mosbah F, Moujahed R, Mousli A, Moussa A, Mrad Dali K, Mrizak N, Msakni I, Mzabi S, Mzali R, Mzoughi Z, Naimi Z, Najjar S, Nakkouri R, Nasr C, Nasrallah D, Nasri M, Njim L, Noubigh GEF, Nouira Y, Nouri O, Omrani S, Osmane W, Ouanes Y, Ouanna N, Oubich F, Oumelreit Belamlih G, Rachdi H, Rafraf F, Rahal K, Raies H, Rammeh S, Rebaii N, Rekik W, Rekik H, Rhim MS, Rhim S, Rihab D, Rjiba R, Rziga T, Saad H, Saad A, Saadi M, Said N, Salah R, Sallemi N, Sassi A, Sassi K, Sassi Mahfoudh A, Sbika W, Sellami A, Serghini M, Sghaier S, Sh Zidi Y, Siala W, Slimane M, Slimani O, Soltani S, Souguir MK, Sridi A, Tabet Zatla A, Tajina D, Talbi G, Tbessi S, Tebra Mrad S, Temessek H, Tlili G, Toumi N, Toumi O, Toumia N, Tounsi H, Trigui E, Triki M, Triki A, Turki M, Werda I, Yahyaoui S, Yahyaoui Y, Yaich A, Yamouni M, Yazid D, Yousfi A, Zaghouani H, Zaied S, Zairi F, Zaraa S, Zehani A, Zenzri Y, Zidi A, Znaidi N, Zouari K, Zouari S, Zoukar O, and Zribi A

Published
2017

11. Mammary Myofibroblastoma with Unusual Morphological and Immunohistochemical Features.

Author

Boudaouara O, Chaari C, Hassini A, and Boudaouara TS

Abstract

Mammary myofibroblastoma (MFB) is a rare mesenchymal tumor, derived from mammary stromal fibro/myofibroblasts, which has various morphological features and characteristic immunohistochemical staining. The epithelioid morphologic variant is defined, accordingly, as a proliferation of exclusively or predominantly (>50%) epithelioid cells, variably embedded in a myxoid to fibrous stroma. These histological and cytological features may pose a diagnostic challenge mainly with metaplastic carcinoma and invasive lobular carcinoma of the breast. Thus, immunohistochemical staining by myofibroblastic markers is helpful for confirming diagnosis. Herein, we present a case of MFB in a 43-year-old female. This case report emphasizes the role of immunohistochemistry as gold standard in the diagnosis of MFB. This case is also being presented because of its unusual radiologic findings, its epithelioid histologic variant mimicking malignancy, and its uncommon immunohistochemical phenotype., Competing Interests: There are no conflicts of interest.

Published
2017
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12. [Atypical morphological feature of a cerebellar tumor].

Author

Boudaouara O, Kallel R, Charfi S, Kassentini M, Boudaouara Z, Mnif H, and Sellami Boudaouara T

Subjects
Aged, Biomarkers, Tumor analysis, Cerebellar Neoplasms diagnosis, Cerebellar Neoplasms diagnostic imaging, Cerebellar Neoplasms surgery, Craniotomy, Female, Hemangioblastoma diagnosis, Hemangioblastoma diagnostic imaging, Hemangioblastoma surgery, Humans, Intracranial Hypertension etiology, Cerebellar Neoplasms pathology, Hemangioblastoma pathology
Published
2016
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