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679 results on '"Bouchelouche, Kirsten"'

3. The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.

Author

Ulhøi, Benedicte, Klingenberg, Søren, Jensen, Jørgen, Kjems, Jørgen, Bouchelouche, Kirsten, Borre, Michael, Damgaard, Christian, Pedersen, Jakob, Kristensen, Lasse, Sørensen, Karina, Hansen, Emma, Fredsøe, Jacob, and Okholm, Trine Line

Subjects
Biomarker, Cancer, Prostate, circRNA, Biomarkers, Tumor, Humans, Male, Neoplasm Recurrence, Local, Prognosis, Prostatectomy, Prostatic Neoplasms, RNA, Circular
Abstract

BACKGROUND: Circular RNAs (circRNAs) constitute a largely unexplored source for biomarker discovery in prostate cancer (PC). Here, we characterize the biomarker potential of circRNAs in PC, where the need for novel diagnostic and prognostic tools to facilitate more personalized management is pressing. METHODS: We profiled the transcriptomic landscape of circRNAs in PC by total RNA sequencing of 31 adjacent-normal and 143 tumor samples from localized (radical prostatectomy (RP)) and metastatic PC patients (cohort 1, training). Diagnostic and prognostic potential was evaluated in cohort 1, and 39 top circRNA candidates were selected for validation in two additional PC cohorts (cohort 2, n = 111; RP cohort 3, n = 191) by NanoString-based expression analysis. Biochemical recurrence (BCR)-free survival was assessed using Kaplan-Meier, univariate, and multivariate Cox regression analyses. The circRNA candidates were further detected in extracellular vesicle (EV)-enriched plasma samples from PC patients and controls (cohort 4, n = 54). RESULTS: Expression of circABCC4, circFAT3, circATRNL1, and circITGA7 was highly cancer-specific (area under the curve 0.71-0.86), while low circITGA7 expression was significantly (P < 0.05) associated with BCR in univariate analysis in two RP cohorts. Moreover, we successfully trained and validated a novel 5-circRNA prognostic signature (circKMD1A/circTULP4/circZNF532/circSUMF1/circMKLN1) significantly associated with BCR beyond routine clinicopathological variables (RP cohort 1: P = 0.02, hazard ratio = 2.1; RP cohort 3: P < 0.001, hazard ratio = 2.1). Lastly, we provide proof-of-principle for detection of candidate circRNAs in EV-enriched plasma samples from PC patients. CONCLUSIONS: circRNAs hold great biomarker potential in PC and display both high cancer specificity and association to disease progression.

Published
2022

8. Teaching Cases in Nuclear Oncology: Kidney and Bladder Cancers

Author

Volterrani, Duccio, Puccini, Giulia, Mazzarri, Sara, Guidoccio, Federica, Kirienko, Margarita, Chiti, Arturo, Pedersen, M. A., Bouchelouche, Kirsten, Volterrani, Duccio, editor, Erba, Paola A., editor, Strauss, H. William, editor, Mariani, Giuliano, editor, and Larson, Steven M., editor

Published
2022
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10. A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer

Author

Ipsen, Malene Blond, Sørensen, Ea Marie Givskov, Thomsen, Emil Aagaard, Weiss, Simone, Haldrup, Jakob, Dalby, Anders, Palmfeldt, Johan, Bross, Peter, Rasmussen, Martin, Fredsøe, Jacob, Klingenberg, Søren, Jochumsen, Mads R., Bouchelouche, Kirsten, Ulhøi, Benedicte Parm, Borre, Michael, Mikkelsen, Jacob Giehm, and Sørensen, Karina Dalsgaard

Published
2022
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17. [ 15 O]H 2 O PET/MRI for Assessment of Complete Response to Neoadjuvant or Induction Chemotherapy in Patients with Muscle-Invasive Bladder Cancer: A Pilot Study.

Author

Körner, Stefanie Korsgaard, Tolbod, Lars Poulsen, Pedersen, Bodil G., Boellaard, Thierry, Milling, Rikke Vilsbøll, Brandt, Simone Buchardt, Agerbæk, Mads, Dyrskjøt, Lars, Bouchelouche, Kirsten, and Jensen, Jørgen B.

Subjects
INDUCTION chemotherapy, NEOADJUVANT chemotherapy, CANCER invasiveness, POSITRON emission tomography, MAGNETIC resonance imaging
Abstract

Background: Accurate assessment of therapy response to chemotherapy could possibly offer a bladder-sparing approach in selected patients with localized muscle-invasive bladder cancer (MIBC). The aim of this study was to evaluate whether [15O]H2O PET/MRI can be used for assessment of complete local pathological response to preoperative chemotherapy in patients with MIBC. Methods: This prospective pilot study included 13 patients with MIBC treated with neoadjuvant or induction chemotherapy and subsequent radical cystectomy. Patients underwent a [15O]H2O PET/MRI scan before chemotherapy and another scan after chemotherapy before radical cystectomy. Volumes of interest were delineated on T2-weighted MRI and transferred to parametric images for dynamic analysis. Tumor blood flow (TBF) was estimated by [15O]H2O PET. Changes in TBF were compared with histopathology. The Wilcoxon matched-pairs signed-ranks test was used for comparing pre- and post-chemotherapy measurements. Results: Mean TBF decreased by 49%. Mean TBF in complete responders (ypT0N0/ypTis) was not significantly different from non-complete responders (≥ypT1) (p = 0.52). Conclusions: Despite a measurable decrease in TBF after chemotherapy treatment, we were not able to estimate a TBF threshold for identifying complete responders to chemotherapy for MIBC patients. Further studies are needed to elucidate the potential of [15O]H2O PET/MRI in assessing therapy response in MIBC. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography with Computed Tomography for Lymph Node Staging in Patients with Upper Tract Urothelial Carcinoma

Author

Voskuilen, Charlotte S., Schweitzer, Donald, Jensen, Jørgen Bjerggaard, Nielsen, Anna M., Joniau, Steven, Muilwijk, Tim, Necchi, Andrea, Azizi, Mounsif, Spiess, Philippe E., Briganti, Alberto, Bandini, Marco, Goffin, Karolien, Bouchelouche, Kirsten, van Werkhoven, Erik, Shariat, Shahrokh F., Xylinas, Evanguelos, Azawi, Nessn H., Ku, Ja Hyeon, Foerster, Beat, van Rhijn, Bas W.G., Vegt, Erik, and Hendricksen, Kees

Published
2020
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26. SO015LBA/#1261 Identifying a safe algorithm for sentinel lymph node mapping in high-risk endometrial cancer; the sentirec endo study

Author

Bjørnholt, Sarah, primary, Mogensen, Ole, additional, Sponholtz, Sara, additional, Bouchelouche, Kirsten, additional, Parner, Erik, additional, Hildebrandt, Malene, additional, Neumann, Gudrun, additional, Markauskas, Algirdas, additional, Bjørn, Signe, additional, Frøding, Ligita, additional, Jakobsen, Annika, additional, Dahl, Katja, additional, and Jensen, Pernille, additional

Published
2023
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27. SO010/#1243 Risks and benefits of a national adoption of sentinel node mapping in low and intermediate risk endometrial cancer -the sentirec-endo study

Author

Bjørnholt, Sarah, primary, Sponholtz, Sara, additional, Mogensen, Ole, additional, Bouchelouche, Kirsten, additional, Parner, Erik, additional, Neumann, Gudrun, additional, Jochumsen, Kirsten, additional, Hamid, Bushra, additional, Davidsen, Morten, additional, Bjørn, Signe, additional, Dahl, Katja, additional, and Jensen, Pernille, additional

Published
2023
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33. Repeatability of [15O]H2O PET imaging for lower extremity skeletal muscle perfusion: a test–retest study.

Author

Christensen, Nana Louise, Sørensen, Jens, Bouchelouche, Kirsten, Madsen, Michael Alle, Buhl, Christian Selmer, and Tolbod, Lars Poulsen

Subjects
FOOT, POSITRON emission tomography, SKELETAL muscle, PERFUSION, PERIPHERAL vascular diseases, INTRACLASS correlation
Abstract

Background: [15O]H2O PET/CT allows noninvasive quantification of tissue perfusion and can potentially play a future role in the diagnosis and treatment of peripheral artery disease. We aimed to evaluate the reliability of dynamic [15O]H2O PET imaging for measuring lower extremity skeletal muscle perfusion. Ten healthy participants underwent same-day test–retest study with six dynamic [15O]H2O PET scans of lower legs and feet. Manual volume-of-interests were drawn in skeletal muscles, and PET time activity curves were extracted. K1 values (mL/min/100 mL) were estimated using a single-tissue compartment model (1TCM), autoradiography (ARG), and parametric imaging with blood input functions obtained from separate heart scans. Results: Resting perfusion values in the muscle groups of the lower legs ranged from 1.18 to 5.38 mL/min/100 mL (ARG method). In the muscle groups of the feet, perfusion values ranged from 0.41 to 3.41 mL/min/100 mL (ARG method). Test–retest scans demonstrated a strong correlation and good repeatability for skeletal muscle perfusion with an intraclass correlation coefficient (ICC) of 0.88 and 0.87 and a repeatability coefficient of 34% and 53% for lower legs and feet, respectively. An excellent correlation was demonstrated when comparing volume-of-interest-based methods (1TCM and ARG) (lower legs: ICC = 0.96, feet: ICC = 0.99). Parametric images were in excellent agreement with the volume-of-interest-based ARG method (lower legs: ICC = 0.97, feet: ICC = 0.98). Conclusion: Parametric images and volume-of-interest-based methods demonstrated comparable resting perfusion values in the lower legs and feet of healthy individuals. The largest variation was seen between individuals, whereas a smaller variation was seen between muscle groups. Repeated measurements of resting blood flow yielded a strong overall correlation for all methods. [ABSTRACT FROM AUTHOR]

Published
2024
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34. #379 A safe algorithm for sentinel lymph node mapping in high-risk endometrial cancer; the SENTIREC endo study

Author

Bjørnholt, Sarah Marie, primary, Mogensen, Ole, additional, Bouchelouche, Kirsten, additional, Parner, Erik Thorlund, additional, Hildebrandt, Malene Grubbe, additional, Neumann, Gudrun, additional, Markauskas, Algirdas, additional, Bjørn, Signe Frahm, additional, Frøding, Ligita Paskeviciute, additional, Jakobsen, Annika Loft, additional, Dahl, Katja, additional, and Jensen, Pernille Tine, additional

Published
2023
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35. #221 The SENTIREC-endo study – risks and benefits of a national adoption of sentinel node mapping in low and intermediate risk endometrial cancer

Author

Bjørnholt, Sarah Marie, primary, Sponholtz, Sara Elizabeth, additional, Mogensen, Ole, additional, Bouchelouche, Kirsten, additional, Parner, Erik Thorlund, additional, Neumann, Gudrun, additional, Jochumsen, Kirsten Marie, additional, Hamid, Bushra Hassan, additional, Davidsen, Morten Bülow, additional, Bjørn, Signe Frahm, additional, Dahl, Katja, additional, and Jensen, Pernille Tine, additional

Published
2023
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36. Myocardial Flow Reserve, an Independent Prognostic Marker of All-Cause Mortality Assessed by 82 Rb PET Myocardial Perfusion Imaging: A Danish Multicenter Study

Author

Højstrup, Signe, primary, Hansen, Kim W., additional, Talleruphuus, Ulrik, additional, Marner, Lisbeth, additional, Bjerking, Louise, additional, Jakobsen, Lars, additional, Christiansen, Evald H., additional, Bouchelouche, Kirsten, additional, Wiinberg, Niels, additional, Guldbrandsen, Kasper, additional, Galatius, Søren, additional, and Prescott, Eva, additional

Published
2023
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46. Coronary Microvascular Disease Assessed by 82-Rubidium Positron Emission Tomography Myocardial Perfusion Imaging Is Associated With Small Vessel Disease of the Kidney and Brain

Author

Højstrup, Signe, Hansen, Kim W, Talleruphuus, Ulrik, Marner, Lisbeth, Galatius, Søren, Rauf, Maira, Bjerking, Louise H, Jakobsen, Lars, Christiansen, Evald H, Bouchelouche, Kirsten, Christensen, Hanne, and Prescott, Eva I B

Subjects
Male, Stroke Volume, Rubidium, Brain/diagnostic imaging, Ventricular Function, Left, Myocardial Perfusion Imaging/methods, Cohort Studies, Positron-Emission Tomography, Coronary Circulation, Humans, Female, Vascular Diseases, Kidney/diagnostic imaging, Aged, Coronary Artery Disease/diagnostic imaging, Microvascular Angina
Abstract

Background Coronary microvascular disease (CMD) may be part of a systemic small vessel disease that also manifests as neurological impairment and kidney disease. However, clinical evidence supporting a potential link is scarce. We assessed whether CMD is associated with an increased risk of small vessel disease in the kidney and brain. Methods and Results A retrospective multicenter (n=3) study of patients clinically referred to 82-rubidium positron emission tomography myocardial perfusion imaging was conducted between January 2018 and August 2020. Exclusion criterion was reversible perfusion defects >5%. CMD was defined as myocardial flow reserve (MFR) ≤2. The primary outcome, microvascular event, was defined by hospital contact for chronic kidney disease, stroke, or dementia. Among 5122 patients, 51.7% were men, median age 69.0 [interquartile range, 60.0-75.0] years, 11.0% had left ventricular ejection fraction ≤40%, and 32.4% had MFR ≤2. MFR was associated with baseline estimated glomerular filtration rate after multivariable adjustment (β=0.04 [95% CI, 0.03-0.05]; P2 (11.6% versus 5.5%, P

Published
2023

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