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2. Public-Private Partnership Models in France and in Europe

Author

Allain, H., Amédée-Manesme, O., Aymé, S., Boubekeur, K., Chabrier, P.-E., Clément, B., Collet, J.-P., Deregnaucourt, J., Habert Ortoli, E., Halioua, E., Hamelin, B., Juillet, Y., Lacombe, D., Lassale, C., Longuet, M., Pletan, Y., Vasmant, D., Vincent, C., Demotes-Mainard, Jacques, Canet, Emmanuel, and Segard, Lionel

Published
2006
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3. Modèles de partenariats Public-Privé en France et en Europe

Author

Allain, H., Amédée-Manesme, O., Aymé, S., Boubekeur, K., Chabrier, P.-E., Clément, B., Collet, J.-P., Deregnaucourt, J., Habert Ortoli, E., Halioua, E., Hamelin, B., Juillet, Y., Lacombe, D., Lassale, C., Longuet, M., Pletan, Y., Vasmant, D., Vincent, C., Demotes-Mainard, Jacques, Canet, Emmanuel, and Segard, Lionel

Published
2006
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4. Controlling the conformation changes associated to electron transfer steps through chemical substitution: Intriguing redox behavior of substituted vinylogous TTF

Author

Bellec, N., Boubekeur, K., Carlier, R., Hapiot, P., Lorcy, D., and Tallec, A.

Subjects
Methylene chloride -- Chemical properties, Acetonitrile -- Chemical properties, Oxidation-reduction reaction -- Methods, Chemicals, plastics and rubber industries
Abstract

Oxidation of a series of tetrathiafulvalene (TTF) vinylogues is investigated in acetonitrile and dichloromethane. Two single-electron transfers or one two-electron process was observed depending on the substituent and the solvent. It is shown that the unusual redox behavior for short-length TTF vinylogues is due to substantial conformation changes concerted with the electron transfers.

Published
2000

14. [Sn.sub.12][O.sub.8][(OH).sub.4][(OEt).sub.28][(HOEt).sub.4]: an additional member in the family of dodecameric oxo clusters

Author

Ribot, F., Martinez-Ferrero, E., Boubekeur, K., Hendrickx, P.M.S., Martins, J.C., Van Lokeren, L., Willem, R., and Blesemans, M.

Subjects
Strontium -- Spectra, Strontium -- Chemical properties, Crystals -- Structure, Crystals -- Research, X-rays -- Diffraction, X-rays -- Analysis, Chemistry
Abstract

The single-crystal X-ray diffraction technique is employed to explain the synthesis and characterization of a new member of the family of dodecameric oxo clusters, [Sn.sub.12][O.sub.8][(OH).sub.4][(OEt).sub.28][(HOEt).sub.4]. Two different types of trimeric subunits are shown to form the structure of the discussed complex.

Published
2008

28. Effects of a potassium channel opener (SDZ PCO 400) on guinea-pig and human pulmonary airways

Author

G. Mathelin, Lazzaro Mazzoni, Boubekeur K, I.D. Chapman, A. Kristersson, E. Schaeublin, J. Morley, and N. Murphy

Subjects
Carbachol, Potassium Channels, medicine.drug_class, Ovalbumin, Muscle Relaxation, Guinea Pigs, Cyclopentanes, Pharmacology, In Vitro Techniques, Bronchospasm, chemistry.chemical_compound, Bronchodilator, Eosinophilia, medicine, Hypersensitivity, Animals, Humans, Benzopyrans, Lung, Inhalation, business.industry, Parasympatholytics, Muscle, Smooth, respiratory system, Airway obstruction, medicine.disease, Bronchodilator Agents, Airway Obstruction, chemistry, Anesthesia, Bronchoconstriction, Potassium channel opener, gamma-Globulins, medicine.symptom, Bronchial Hyperreactivity, business, Histamine, medicine.drug, Research Article
Abstract

1. SDZ PCO 400 evoked dose-related relaxation of isolated airway smooth muscle. For human bronchus precontracted by endogenous tone or addition of carbachol (10(-5) M), IC50 values were 1.74 microM and 1.82 microM respectively. With guinea-pig trachea contracted by endogenous tone, a comparable IC50 (1.79 microM) was observed, but no IC50 (less than 100 microM) could be determined following contraction by carbachol (10(-6) M). 2. Airway obstruction induced by intravenous bombesin in the anaesthetized ventilated guinea-pig was diminished by intravenous injection of SDZ PCO 400 (ID50 54 micrograms kg-1) or by introduction into the duodenum (ID50 1.0 mg kg-1). Inhalation of nebulized SDZ PCO 400 (0.1 mg kg-1) diminished airway obstruction due to intravenous injection of histamine (3.2-5.6 micrograms kg-1) for up to 20 min. 3. Increased bronchoconstrictor responses to bombesin (180-240 ng kg-1) following intravenous infusion of platelet activating factor (PAF) or (+/-)-isoprenaline, or to histamine (1.0-3.2 micrograms kg-1) following intravenous injections of immune complexes, were suppressed following concomitant intravenous infusion of SDZ PCO 400 (ID50 0.3 mg kg-1 h-1, 1.0 mg kg-1 h-1 and 0.1 mg kg-1 h-1 respectively). 4. Intravenous injection of SDZ PCO 400 (0.1 mg kg-1) effected transient (less than 10 min) inhibition of histamine-induced bronchospasm, yet diminished, for prolonged periods [up to 40 min] the enhanced bronchoconstrictor responses to histamine that followed intravenous injections of immune complexes.The capacity of SDZ PCO 400 to resolve such established airway hyperreactivity was prevented by prior intraduodenal instillation of a potassium channel antagonist, glibenclamide (30 mg kg-').5. In sensitized guinea-pigs, SDZ PCO 400 inhaled as a dry powder (5.7 mg kg-') suppressed development of allergic airway hyperreactivity to histamine (1.8-3.2;pg kg-', i.v.), but failed to diminish accumulation of eosinophils or other inflammatory cells within the airway lumen 24 h after inhalation of ovalbumin.6. Preincubation (30 min) of isolated sensitized trachea of guinea-pig with SDZ PCO 400 (10-5-10-4M) did not influence contractile responses to ovalbumin. However in anaesthetized sensitized guinea-pigs,insufflation of SDZ PCO 400 (1.25 mg) as a powder substantially diminished airway obstruction that followed inhalation of ovalbumin. This effect was prevented by prior vagal section.7. It is concluded that SDZ PCO 400 reduces airway obstruction not only through direct actions on airway smooth muscle but also by impairing the expression of airway hyperreactivity, without directly influencing inflammatory events in the airways.

Published
1992

31. Modèles de partenariats Public-Privé en France et en Europe

Author

Demotes-Mainard, Jacques, primary, Canet, Emmanuel, additional, Segard, Lionel, additional, Allain, H., additional, Amédée-Manesme, O., additional, Aymé, S., additional, Boubekeur, K., additional, Chabrier, P.-E., additional, Clément, B., additional, Collet, J.-P., additional, Deregnaucourt, J., additional, Habert Ortoli, E., additional, Halioua, E., additional, Hamelin, B., additional, Juillet, Y., additional, Lacombe, D., additional, Lassale, C., additional, Longuet, M., additional, Pletan, Y., additional, Vasmant, D., additional, and Vincent, C., additional

Published
2006
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32. Public-Private Partnership Models in France and in Europe

Author

Demotes-Mainard, Jacques, primary, Canet, Emmanuel, additional, Segard, Lionel, additional, Allain, H., additional, Amédée-Manesme, O., additional, Aymé, S., additional, Boubekeur, K., additional, Chabrier, P.-E., additional, Clément, B., additional, Collet, J.-P., additional, Deregnaucourt, J., additional, Habert Ortoli, E., additional, Halioua, E., additional, Hamelin, B., additional, Juillet, Y., additional, Lacombe, D., additional, Lassale, C., additional, Longuet, M., additional, Pletan, Y., additional, Vasmant, D., additional, and Vincent, C., additional

Published
2006
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33. Eosinophil accumulation in pulmonary airways of guinea-pigs induced by exposure to an aerosol of platelet-activating factor: effect of anti-asthma drugs

Author

S. Aoki, S. Sanjar, D. Smith, M. A. Kings, J. Morley, I.D. Chapman, and Boubekeur K

Subjects
Ketotifen, Blood Platelets, Male, Time Factors, Neutrophils, Mepyramine, Guinea Pigs, Bronchi, Pharmacology, In Vitro Techniques, chemistry.chemical_compound, medicine, Eosinophilia, Animals, Platelet Activating Factor, Lung, Aerosols, medicine.diagnostic_test, Inhalation, Platelet-activating factor, business.industry, Eosinophil, respiratory system, Asthma, respiratory tract diseases, Eosinophils, Bronchoalveolar lavage, medicine.anatomical_structure, chemistry, Immunology, lipids (amino acids, peptides, and proteins), medicine.symptom, Pulmonary alveolus, business, medicine.drug, Research Article
Abstract

1. Exposure of guinea-pigs to aerosols of platelet activating factor (PAF) (0.01 to 100 micrograms ml-1) induced a dose-dependent increased incidence of eosinophils in bronchoalveolar lavage fluid (BAL) at 48 h. Total leucocyte numbers and the percentages of lymphocytes and neutrophils were unchanged in BAL fluid. 2. Increased numbers of eosinophils were detected in BAL 1 h after exposure to PAF but eosinophilia was not maximal until 48 h. One week after exposure to PAF, the percentage of eosinophils in BAL was within the normal range. 3. Depletion of circulating platelets or neutrophils by intravenous injection of specific antisera did not modify accumulation of eosinophils in the airway lumen following inhalation of PAF (10 micrograms ml-1). 4. PAF-induced pulmonary airway eosinophil accumulation was inhibited by treatment with SDZ 64-412, a selective PAF-antagonist, whether the compound was administered before, or 30 min after, inhalation of PAF. 5. Pulmonary airway eosinophil accumulation due to inhaled PAF (10 micrograms ml-1) was inhibited by prior treatment with aminophylline, cromoglycate, ketotifen, dexamethasone and AH 21-132. 6. Pulmonary airway eosinophil accumulation due to inhaled PAF (10 micrograms ml-1) was not inhibited by prior treatment with indomethacin, salbutamol or mepyramine.

Published
1990

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