44 results on '"Bottomley N"'
Search Results
2. The clinical symptom profile of early radiographic knee arthritis: a pain and function comparison with advanced disease
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Jones, L. D., Bottomley, N., Harris, K., Jackson, W., Price, A. J., and Beard, D. J.
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- 2016
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3. Revision total knee replacement case-mix at a major revision centre
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Sabah, S, von Fritsch, L, Khan, T, Shearman, AD, Rajasekaran, RB, Taylor, A, Kendrick, B, Jackson, W, Bottomley, N, Palmer, A, Gibbons, C, Murray, D, Beard, D, Price, A, and Alvand, A
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Orthopedics and Sports Medicine - Published
- 2022
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4. Does delayed physiotherapy following total knee replacement increase post-operative stiffness? A new angle on knee flexion
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Jenkins, C., primary, Jackson, W., additional, Bottomley, N., additional, Price, A., additional, Murray, D., additional, and Barker, K., additional
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- 2021
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5. Length of stay following an accelerated knee arthroplasty pathway is age dependent
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Barker, K., primary, Jackson, W., additional, Bottomley, N., additional, Price, A., additional, Murray, D., additional, and Jenkins, C., additional
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- 2021
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6. Early results of fixed-bearing unicompartmental knee replacement designed for the lateral compartment
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Asadollahi, S, Wilson, HA, Thomson, FR, Vaz, K, Middleton, R, Jenkins, C, Alvand, A, Bottomley, N, Dodd, CA, Price, AJ, Murray, DW, and Jackson, WF
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Adult ,Aged, 80 and over ,Male ,Reoperation ,Knee Joint ,Middle Aged ,Osteoarthritis, Knee ,Prosthesis Design ,Prosthesis Failure ,Treatment Outcome ,Humans ,Orthopedics and Sports Medicine ,Surgery ,Female ,Arthroplasty, Replacement, Knee ,Knee Prosthesis ,Aged - Abstract
Background Isolated lateral compartment knee arthritis is less prevalent than medial. While the reported results of medial unicompartmental knee replacement (UKR) have been good and comparable to total knee replacement, the results of lateral UKR have been mixed. We present the short-term results and survivorship of a fixed-bearing UKR designed specifically for the lateral compartment. Methods We report the result of 130 primary fixed-bearing lateral Oxford (FLO) UKRs (123 patients) performed between 2015 and 2019 with a minimum follow-up of 1 year. The indications for lateral UKR were: isolated lateral osteoarthritis (n = 122), post-trauma (n = 5) and osteonecrosis (n = 3). The mean age was 69.1 (± 11.6), mean BMI 28.4 (± 4.9), 66.9% female, 60% right-sided, and mean follow-up 3 (range 1–4.8 years, standard deviation ± 1) years. The primary outcome measure was the Oxford knee score (OKS). Survival analysis was performed with “revision for any reason”, “reoperation”, and “implant failure” as the endpoints. Results Six patients died from unrelated reasons. None of the implants failed. One required the addition of a medial UKR for medial arthritis. There were no other reoperations. At 4 years, the survival for implant failure was 100% and for both revision and all reoperations was 99.5% (95% CI 96.7–99.9%). At the last review, at a mean of 3 years, the mean Oxford knee score was 41. Conclusion The good survivorship and outcome scores suggest that UKR designed for the lateral compartment is an excellent alternative to total knee replacement in selected patients with isolated lateral tibiofemoral arthritis at short-term follow-up.
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- 2021
7. The implications of damage to the lateral femoral condyle on medial unicompartmental knee replacement
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Kendrick, B. J. L., Rout, R., Bottomley, N. J., Pandit, H., Gill, H. S., Price, A. J., Dodd, C. A. F., and Murray, D. W.
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- 2010
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8. MANIPULATION UNDER ANAESTHETIC FOLLOWING PRIMARY KNEE ARTHROPLASTY IS ASSOCIATED WITH A HIGHER RATE OF SUBSEQUENT REVISION KNEE ARTHROPLASTY
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Abram, S., primary, Yusuf, B., additional, Alvand, A., additional, Sabah, S., additional, Jackson, W., additional, Bottomley, N., additional, Beard, D., additional, and Price, A., additional
- Published
- 2020
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9. EARLY RESULTS OF FIXED BEARING UNICOMPARTMENTAL KNEE REPLACEMENT DESIGNED FOR THE LATERAL COMPARTMENT
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Asadollahi, S., primary, Thomson, F.R., additional, Wilson, H.A., additional, Middleton, R.M., additional, Jenkins, C., additional, Alvand, A., additional, Bottomley, N., additional, Dodd, C.A., additional, Murray, D.W., additional, Price, A.J., additional, and Jackson, W.F., additional
- Published
- 2020
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10. How a quality improvement project following a redesigned clinical pathway reaped benefits beyond the original target population
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Jenkins, C., primary, Jackson, W., additional, Bottomley, N., additional, Murray, D., additional, Price, A., additional, and Barker, K., additional
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- 2020
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11. THE MAGNETIC RESONANCE IMAGING DESCRIPTION OF ANTEROMEDIAL OSTEOARTHRITIS OF THE KNEE
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Bottomley, N J, McNally, E G, Ostlere, S, Beard, D J, Gill, H S, Kendrick, B JL, Jackson, W, Gulati, A, Simpson, D J, Murray, D W, Dodd, C AF, and Price, A J
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- 2010
12. POLYETHYLENE WEAR IN OXFORD UNICOMPARTMENTAL KNEE REPLACEMENT - A RETRIEVAL STUDY OF 47 BEARINGS.
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Kendrick, B J L, Simpson, D, Bottomley, N J, Marks, B, Pandit, H, Beard, D, Gill, H S, Dodd, C A, Murray, D W, and Price, A J
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- 2010
13. Displacement of the common peroneal nerve in posterolateral corner injuries of the knee
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Bottomley, N., Williams, A., Birch, R., Noorani, A., Lewis, A., and Lavelle, J.
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- 2005
14. Delaying knee flexion after unicompartmental knee replacement leads to improved outcomes: changes to a physiotherapy pathway
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Jenkins, C., primary, Jackson, W., additional, Bottomley, N., additional, Price, A., additional, Murray, D., additional, and Barker, K., additional
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- 2019
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15. Outcome-based commissioning of knee arthroplasty in the NHS
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Middleton, R., primary, Wilson, H. A., additional, Alvand, A., additional, Abram, S. G. F., additional, Bottomley, N., additional, Jackson, W., additional, and Price, A., additional
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- 2018
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16. Recruitment, randomization and retention: UK experience of the ‘3 RS’ in osteoarthritis drug trials targeting pain
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Masters, S., primary, Lovegrove, P., additional, Pereira, C., additional, Goff, M., additional, Lang, G., additional, Vincent, T.L., additional, Barker, K., additional, Arden, N.K., additional, Taylor, A., additional, Bottomley, N., additional, Jackson, W., additional, Price, A., additional, and Watt, F.E., additional
- Published
- 2018
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17. Recovery following Oxford Unicompartmental Knee Replacement: less is more, later is better
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Jenkins, C., primary, Jackson, W., additional, Bottomley, N., additional, Veiga, N., additional, and Barker, K., additional
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- 2017
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18. 0130 - PROMS & EPISODE LINKAGE IN UNICOMPARTMENTAL KNEE REPLACEMENT - CODING CONSTERNATIONS
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Middleton, R.M., primary, Bottomley, N., additional, Jackson, W.F.M., additional, and Price, A.J., additional
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- 2017
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19. BEZIER CURVES FOR MEASURING JOINT SPACE ON KNEE RADIOGRAPHS - REPRODUCIBILITY AND VALIDITY
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Leyland, KM, Hunter, D, Judge, A, Bottomley, N, Hart, D, Gill, R, Javaid, MK, and Arden, NK
- Published
- 2016
20. A survival analysis of 1084 knees of the Oxford unicompartmental knee arthroplasty
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Bottomley, N., primary, Jones, L. D., additional, Rout, R., additional, Alvand, A., additional, Rombach, I., additional, Evans, T., additional, Jackson, W. F. M., additional, Beard, D. J., additional, and Price, A. J., additional
- Published
- 2016
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21. Agreement between histopathologic regression and MRI Tumour Regression (mrTRG) scales used to assess response for rectal cancers
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Siddiqui, M., Balyansikova, S., Nagtegaal, I., West, N., Murray, G., Bosch, S., A. van-Tilberg, Kaur, C., Wotherspoon, A., Bottomley, N., Finlayson, C., Tekkis, P., Rasheed, S., Abulafi, A., and Brown, G.
- Published
- 2018
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22. A COMPARISON OF FOUR RADIOGRAPHIC SCORING METHODS FOR KNEE OSTEOARTHRITIS - SHORT AND MEDIUM TERM REPRODUCIBILITY
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Leyland, K, Bottomley, N, Judge, A, Spector, T, Hart, D, Javaid, M, and Arden, K
- Published
- 2011
23. The clinical symptom profile of early radiographic knee arthritis: a pain and function comparison with advanced disease
- Author
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Jones, L. D., primary, Bottomley, N., additional, Harris, K., additional, Jackson, W., additional, Price, A. J., additional, and Beard, D. J., additional
- Published
- 2014
- Full Text
- View/download PDF
24. 10 Year survivorship of the medial Oxford unicompartmental knee arthroplasty. A 1000 patient non-designer series - the effect of surgical grade and supervison
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Jones, L., primary, Bottomley, N., additional, Pandit, H., additional, Beard, D., additional, Jackson, W., additional, and Price, A., additional
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- 2012
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25. 407 A COMPARISON OF FOUR RADIOGRAPHIC SCORING METHODS FOR KNEE OSTEOARTHRITIS – SHORT AND MEDIUM TERM REPRODUCIBILITY
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Leyland, K., primary, Bottomley, N., additional, Judge, A., additional, Spector, T., additional, Hart, D., additional, Javaid, M.K., additional, and Arden, N.K., additional
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- 2011
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26. 391 BEZIER CURVES FOR MEASURING JOINT SPACE ON KNEE RADIOGRAPHS – REPRODUCIBILITY AND VALIDHY
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Leyland, K.M., primary, Hunter, D., additional, Judge, A., additional, Bottomley, N., additional, Hart, D., additional, Gill, R., additional, Javaid, M.K., additional, and Arden, N.K., additional
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- 2011
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27. ASK: a virtual enquiry desk -- a case study.
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Beard J, Bottomley N, Geeson R, and Spencer S
- Abstract
A review of a five-year project to design, implement, promote and evaluate a virtual enquiry desk in a new British University. The service specification, target audience and process of development are documented and discussed. The results of an evaluative survey of 30 users reveal that rather than distance or part-time students, the majority of users are full-time undergraduate students submitting questions within 15 miles of the University during core opening times. It is clear that the Library is still operating within a 'hybrid' rather than purely electronic environment, and the implications of this for partner colleges are considered. The paper concludes with some pointers for the future of a service that is now firmly established as part of the subject advice service offered to Bournemouth University students 24 hours a day, seven days a week. [ABSTRACT FROM AUTHOR]
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- 2003
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28. The Work of the Royal Air Force on the North-West Frontier.
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Bottomley, N. H.
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- 1939
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29. Indications for lateral unicompartmental knee arthroplasty - A systematic review.
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Ifigenia Bunyoz K, Troelsen A, Gromov K, Alvand A, Bottomley N, Jackson W, and Price A
- Abstract
Background: While evidence-based indications are established for medial UKA, the optimal indications for lateral UKA have not received as much attention. There exists significant anatomical, osteoarthritis phenotype, kinematic, and surgical technique differences between medial and lateral UKA. The indications for the two procedures may therefore not be identical. Hence, this review aims to access the indications and contraindications in published cohort studies on lateral UKA, to assess if consensus exists., Methods: In May 2024, a systematic review was carried out following the Preferred Reporting Item for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Cohort studies on lateral UKA with a clear report of indications were included. Data on indications and contraindications were extracted to evaluate consensus. Furthermore, outcomes related to expanding or testing indications for lateral UKA were obtained., Results: 38 studies were included. Lateral UKA was mostly performed for primary lateral osteoarthritis. The most reported indications were moderate to severe lateral osteoarthritis, with full-thickness cartilage in the medial compartment, intact ligaments, a correctable valgus deformity, and a flexion contracture < 10-15 degrees. The most reported contraindications were inflammatory arthritis and severe patellofemoral involvement. Eight studies investigated different indications on outcomes after lateral UKA; suggesting better outcomes for primary lateral osteoarthritis, no significant impact from the state of the patellofemoral joint, and conflicting results regarding age and weight., Conclusion: While the literature suggests that some agreement does exist regarding indications for lateral UKA, a strong consensus was not found, indicating that well-defined and consensus-based indications for lateral UKA do not yet exist., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
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- 2024
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30. Anteromedial knee osteoarthritis (AMOA) evaluated with magnetic resonance imaging (MRI): a cohort study of 100 patients.
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Bunyoz KI, Dixon J, Patel J, Troelsen A, Alvand A, Jackson W, Price A, and Bottomley N
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- Humans, Female, Male, Middle Aged, Aged, Cohort Studies, Arthroplasty, Replacement, Knee methods, Cartilage, Articular diagnostic imaging, Cartilage, Articular pathology, Aged, 80 and over, Retrospective Studies, Knee Joint diagnostic imaging, Knee Joint surgery, Magnetic Resonance Imaging methods, Osteoarthritis, Knee diagnostic imaging, Osteoarthritis, Knee surgery
- Abstract
Introduction: Magnetic resonance imaging (MRI) scans are increasingly used for knee osteoarthritis evaluation and preoperative planning before unicompartmental knee arthroplasty (UKA), and often patients already have MRI scans before their initial surgeon consultation. This highlights the need for surgeons to understand anteromedial osteoarthritis (AMOA) patterns on MRI. Hence, we aim to describe MRI findings in patients with AMOA meeting current indications for medial UKA., Materials and Methods: We analysed MRI scans from 100 knees evaluated for UKA between 2006 and 2013. Inclusion criteria comprised full-thickness medial compartment loss and intact lateral compartment joint space on preoperative radiographs. Assessment included cartilage lesions, osteophytes, meniscal damage, and anterior-cruciate ligament (ACL) status on tibial and femoral surfaces. Final decision to proceed with UKA relied on intraoperative findings, independent of MRI., Results: Complete anteromedial tibial and femoral cartilage loss preserved posterior cartilage rims was evident in all cases. Cartilage thinning occurred in the lateral compartment in 34% of cases. While 62% displayed lateral osteophytes, only 6 exhibited small areas of full-thickness cartilage loss. ACL abnormalities varied: 27% normal, 3% ruptured, and 70% had intrasubstance high signal. Larger osteophytes in the medial (p = 0.012) and lateral (p = 0.002) intercondylar notch correlated significantly with ACL damage. All underwent medial UKA, with no evidence of areas with full lateral compartment cartilage loss intraoperatively., Conclusions: The MRI findings confirmed the radiographic diagnosis of bone-on-bone medial disease but highlights a range of findings in the ACL, lateral compartment, and patellofemoral joint compartment for patients who met the current x-ray and intraoperative indication for UKA. Further research is required to understand if these MRI changes will affect long-term outcomes., (© 2024. The Author(s).)
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- 2024
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31. Comparison of surgical or non-surgical management for non-acute anterior cruciate ligament injury: the ACL SNNAP RCT.
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Beard DJ, Davies L, Cook JA, Stokes J, Leal J, Fletcher H, Abram S, Chegwin K, Greshon A, Jackson W, Bottomley N, Dodd M, Bourke H, Shirkey BA, Paez A, Lamb SE, Barker KL, Phillips M, Brown M, Lythe V, Mirza B, Carr A, Monk P, Areia CM, O'Leary S, Haddad F, Wilson C, and Price A
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- Humans, Male, Female, Adult, United Kingdom, Quality of Life, Quality-Adjusted Life Years, Middle Aged, Young Adult, State Medicine, Joint Instability surgery, Joint Instability rehabilitation, Adolescent, Technology Assessment, Biomedical, Anterior Cruciate Ligament Injuries surgery, Anterior Cruciate Ligament Injuries rehabilitation, Cost-Benefit Analysis, Anterior Cruciate Ligament Reconstruction rehabilitation
- Abstract
Background: Anterior cruciate ligament injury of the knee is common and leads to decreased activity and risk of secondary osteoarthritis of the knee. Management of patients with a non-acute anterior cruciate ligament injury can be non-surgical (rehabilitation) or surgical (reconstruction). However, insufficient evidence exists to guide treatment., Objective(s): To determine in patients with non-acute anterior cruciate ligament injury and symptoms of instability whether a strategy of surgical management (reconstruction) without prior rehabilitation was more clinically and cost-effective than non-surgical management (rehabilitation)., Design: A pragmatic, multicentre, superiority, randomised controlled trial with two-arm parallel groups and 1:1 allocation. Due to the nature of the interventions, no blinding could be carried out., Setting: Twenty-nine NHS orthopaedic units in the United Kingdom., Participants: Participants with a symptomatic (instability) non-acute anterior cruciate ligament-injured knee., Interventions: Patients in the surgical management arm underwent surgical anterior cruciate ligament reconstruction as soon as possible and without any further rehabilitation. Patients in the rehabilitation arm attended physiotherapy sessions and only were listed for reconstructive surgery on continued instability following rehabilitation. Surgery following initial rehabilitation was an expected outcome for many patients and within protocol., Main Outcome Measures: The primary outcome was the Knee Injury and Osteoarthritis Outcome Score 4 at 18 months post randomisation. Secondary outcomes included return to sport/activity, intervention-related complications, patient satisfaction, expectations of activity, generic health quality of life, knee-specific quality of life and resource usage., Results: Three hundred and sixteen participants were recruited between February 2017 and April 2020 with 156 randomised to surgical management and 160 to rehabilitation. Forty-one per cent ( n = 65) of those allocated to rehabilitation underwent subsequent reconstruction within 18 months with 38% ( n = 61) completing rehabilitation and not undergoing surgery. Seventy-two per cent ( n = 113) of those allocated to surgery underwent reconstruction within 18 months. Follow-up at the primary outcome time point was 78% ( n = 248; surgical, n = 128; rehabilitation, n = 120). Both groups improved over time. Adjusted mean Knee Injury and Osteoarthritis Outcome Score 4 scores at 18 months had increased to 73.0 in the surgical arm and to 64.6 in the rehabilitation arm. The adjusted mean difference was 7.9 (95% confidence interval 2.5 to 13.2; p = 0.005) in favour of surgical management. The per-protocol analyses supported the intention-to-treat results, with all treatment effects favouring surgical management at a level reaching statistical significance. There was a significant difference in Tegner Activity Score at 18 months. Sixty-eight per cent ( n = 65) of surgery patients did not reach their expected activity level compared to 73% ( n = 63) in the rehabilitation arm. There were no differences between groups in surgical complications ( n = 1 surgery, n = 2 rehab) or clinical events ( n = 11 surgery, n = 12 rehab). Of surgery patients, 82.9% were satisfied compared to 68.1% of rehabilitation patients. Health economic analysis found that surgical management led to improved health-related quality of life compared to non-surgical management (0.052 quality-adjusted life-years, p = 0.177), but with higher NHS healthcare costs (£1107, p < 0.001). The incremental cost-effectiveness ratio for the surgical management programme versus rehabilitation was £19,346 per quality-adjusted life-year gained. Using £20,000-30,000 per quality-adjusted life-year thresholds, surgical management is cost-effective in the UK setting with a probability of being the most cost-effective option at 51% and 72%, respectively., Limitations: Not all surgical patients underwent reconstruction, but this did not affect trial interpretation. The adherence to physiotherapy was patchy, but the trial was designed as pragmatic., Conclusions: Surgical management (reconstruction) for non-acute anterior cruciate ligament-injured patients was superior to non-surgical management (rehabilitation). Although physiotherapy can still provide benefit, later-presenting non-acute anterior cruciate ligament-injured patients benefit more from surgical reconstruction without delaying for a prior period of rehabilitation., Future Work: Confirmatory studies and those to explore the influence of fidelity and compliance will be useful., Trial Registration: This trial is registered as Current Controlled Trials ISRCTN10110685; ClinicalTrials.gov Identifier: NCT02980367., Funding: This award was funded by the National Institute of Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: 14/140/63) and is published in full in Health Technology Assessment ; Vol. 28, No. 27. See the NIHR Funding and Awards website for further award information.
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- 2024
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32. Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial.
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Beard DJ, Davies L, Cook JA, Stokes J, Leal J, Fletcher H, Abram S, Chegwin K, Greshon A, Jackson W, Bottomley N, Dodd M, Bourke H, Shirkey BA, Paez A, Lamb SE, Barker K, Phillips M, Brown M, Lythe V, Mirza B, Carr A, Monk P, Morgado Areia C, O'Leary S, Haddad F, Wilson C, and Price A
- Subjects
- Humans, Knee Joint surgery, State Medicine, Treatment Outcome, Anterior Cruciate Ligament Injuries diagnosis, Anterior Cruciate Ligament Injuries etiology, Anterior Cruciate Ligament Injuries surgery, Anterior Cruciate Ligament Reconstruction adverse effects, Anterior Cruciate Ligament Reconstruction methods, Knee Injuries etiology, Knee Injuries rehabilitation, Knee Injuries surgery
- Abstract
Background: Anterior cruciate ligament (ACL) rupture is a common debilitating injury that can cause instability of the knee. We aimed to investigate the best management strategy between reconstructive surgery and non-surgical treatment for patients with a non-acute ACL injury and persistent symptoms of instability., Methods: We did a pragmatic, multicentre, superiority, randomised controlled trial in 29 secondary care National Health Service orthopaedic units in the UK. Patients with symptomatic knee problems (instability) consistent with an ACL injury were eligible. We excluded patients with meniscal pathology with characteristics that indicate immediate surgery. Patients were randomly assigned (1:1) by computer to either surgery (reconstruction) or rehabilitation (physiotherapy but with subsequent reconstruction permitted if instability persisted after treatment), stratified by site and baseline Knee Injury and Osteoarthritis Outcome Score-4 domain version (KOOS4). This management design represented normal practice. The primary outcome was KOOS4 at 18 months after randomisation. The principal analyses were intention-to-treat based, with KOOS4 results analysed using linear regression. This trial is registered with ISRCTN, ISRCTN10110685, and ClinicalTrials.gov, NCT02980367., Findings: Between Feb 1, 2017, and April 12, 2020, we recruited 316 patients. 156 (49%) participants were randomly assigned to the surgical reconstruction group and 160 (51%) to the rehabilitation group. Mean KOOS4 at 18 months was 73·0 (SD 18·3) in the surgical group and 64·6 (21·6) in the rehabilitation group. The adjusted mean difference was 7·9 (95% CI 2·5-13·2; p=0·0053) in favour of surgical management. 65 (41%) of 160 patients allocated to rehabilitation underwent subsequent surgery according to protocol within 18 months. 43 (28%) of 156 patients allocated to surgery did not receive their allocated treatment. We found no differences between groups in the proportion of intervention-related complications., Interpretation: Surgical reconstruction as a management strategy for patients with non-acute ACL injury with persistent symptoms of instability was clinically superior and more cost-effective in comparison with rehabilitation management., Funding: The UK National Institute for Health Research Health Technology Assessment Programme., Competing Interests: Declaration of interests We declare no competing interests., (Copyright © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2022
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33. Early results of fixed-bearing unicompartmental knee replacement designed for the lateral compartment.
- Author
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Asadollahi S, Wilson HA, Thomson FR, Vaz K, Middleton R, Jenkins C, Alvand A, Bottomley N, Dodd CA, Price AJ, Murray DW, and Jackson WF
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prosthesis Design, Prosthesis Failure, Reoperation, Treatment Outcome, Arthroplasty, Replacement, Knee methods, Knee Joint surgery, Knee Prosthesis, Osteoarthritis, Knee surgery
- Abstract
Background: Isolated lateral compartment knee arthritis is less prevalent than medial. While the reported results of medial unicompartmental knee replacement (UKR) have been good and comparable to total knee replacement, the results of lateral UKR have been mixed. We present the short-term results and survivorship of a fixed-bearing UKR designed specifically for the lateral compartment., Methods: We report the result of 130 primary fixed-bearing lateral Oxford (FLO) UKRs (123 patients) performed between 2015 and 2019 with a minimum follow-up of 1 year. The indications for lateral UKR were: isolated lateral osteoarthritis (n = 122), post-trauma (n = 5) and osteonecrosis (n = 3). The mean age was 69.1 (± 11.6), mean BMI 28.4 (± 4.9), 66.9% female, 60% right-sided, and mean follow-up 3 (range 1-4.8 years, standard deviation ± 1) years. The primary outcome measure was the Oxford knee score (OKS). Survival analysis was performed with "revision for any reason", "reoperation", and "implant failure" as the endpoints., Results: Six patients died from unrelated reasons. None of the implants failed. One required the addition of a medial UKR for medial arthritis. There were no other reoperations. At 4 years, the survival for implant failure was 100% and for both revision and all reoperations was 99.5% (95% CI 96.7-99.9%). At the last review, at a mean of 3 years, the mean Oxford knee score was 41., Conclusion: The good survivorship and outcome scores suggest that UKR designed for the lateral compartment is an excellent alternative to total knee replacement in selected patients with isolated lateral tibiofemoral arthritis at short-term follow-up., (© 2022. The Author(s).)
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- 2022
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34. New instrumentation system for cementless mobile-bearing unicompartmental knee arthroplasty improves surgical performance particularly for trainees.
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Alvand A, Wilson HA, Sabah SA, Middleton R, Bottomley N, Jackson WFM, and Price AJ
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- Aged, Cohort Studies, Female, Humans, Knee Joint diagnostic imaging, Knee Joint surgery, Male, Reproducibility of Results, Retrospective Studies, Treatment Outcome, Arthroplasty, Replacement, Knee, Knee Prosthesis, Osteoarthritis, Knee diagnostic imaging, Osteoarthritis, Knee surgery
- Abstract
Background: Mobile-bearing medial-unicompartmental knee arthroplasty (mUKA) has a documented learning curve. New instrumentation has been designed with the aim of reducing the technical challenges of this procedure. The primary aim of this study was to evaluate the technical performance of mUKA using new (Microplasty) versus older (Phase III) instrumentation, performed by expert surgeons and trainees. Secondary aims were to evaluate functional outcome and mid-term survivorship., Methods: A time-based comparative cohort study was performed between 2009 and 2015 at a high-volume centre. 273 patients (273 knees, 49.5% female) of mean age 67.8 (standard deviation 10.1) years underwent mUKA. 153 (56.0%) procedures used Microplasty instruments and 120 procedures (44.0%) used Phase III instruments., Results: Non-optimal bearing usage was less frequent with Microplasty than Phase III instruments (24 knees [15.7%] versus 33 knees [27.5%], p = 0.024), with differences due to improved trainee performance. Femoral component sagittal alignment outliers were less frequent with Microplasty, but this was not statistically significant (9 knees [5.9%] versus 13 knees [10.8%], p = 0.18). Post-operative Oxford Knee Scores (OKS) were better with Microplasty (median 42 points [interquartile range 38-44]) compared to Phase III (median 39.5 points [IQR 33-44]), which was statistically significant (p = 0.023), but not clinically meaningful. The overall 5-year Kaplan-Meier (KM) survival estimate was 99.3% (95% CI 97.0-99.8%), with no differences between Microplasty and Phase III instrumentation., Conclusions: New instrumentation improved the reliability of the proximal tibial resection in trainees. Further research is warranted to investigate whether Microplasty instrumentation shortens the learning curve for medial UKA., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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35. Debridement, antibiotics and implant retention (DAIR) for the management of knee prosthetic joint infection.
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Vaz K, Scarborough M, Bottomley N, Kendrick B, Taylor A, Price A, Alvand A, and Jackson W
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- Humans, Retrospective Studies, Treatment Outcome, Anti-Bacterial Agents therapeutic use, Debridement methods, Knee Joint surgery, Prosthesis-Related Infections therapy
- Abstract
Background: While two-stage revision arthroplasty is viewed as the gold standard for the treatment of knee periprosthetic joint infection (PJI) in terms of infection eradication, it is associated with significant cost along with patient morbidity and mortality. Debridement, antibiotics, and implant retention (DAIR) is an attractive option as it has demonstrated better patient outcomes, comparable implant longevity to primary arthroplasty, and significantly reduced cost when successful. Given the heterogeneity of what is defined as a DAIR the literature is highly variable in terms of its efficacy from the perspective of infection eradication., Methods: In the setting of a previously well-functioning, well-fixed arthroplasty with an acceptable soft tissue envelope and a treatable organism we report our methods for proceeding with a DAIR procedure, both unicompartmental and total knee., Results: With the above methods we have demonstrated improved patient outcomes when compared to one- or two-stage arthroplasty with lower patient morbidity. Implant longevity in the setting of a successful DAIR is equivalent to those of a primary arthroplasty., Conclusions: With appropriate indications and good surgical technique as described we believe DAIR is an excellent option in the treatment of periprosthetic joint infection. We hope that with a well-defined protocol as outlined we can gain a better understanding of the efficacy of DAIR procedure with more homogeneity to the procedure to better define when they are most successful while improving patient outcomes and reducing cost., Competing Interests: Declaration of competing interest The above authors have no conflicts of interest with what is presented., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
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36. Management of aseptic failure of the mobile-bearing Oxford unicompartmental knee arthroplasty.
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Sabah SA, Lim CT, Middleton R, von Fritsch L, Bottomley N, Jackson WFM, Price AJ, and Alvand A
- Subjects
- Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Male, Middle Aged, Osteoarthritis, Knee surgery, Patient Outcome Assessment, Retrospective Studies, Arthroplasty, Replacement, Knee, Knee Prosthesis adverse effects, Prosthesis Failure, Reoperation
- Abstract
Background: Unicompartmental knee arthroplasty (UKA) accounts for 9.1% of primary knee arthroplasties (KAs) in the UK. However, wider uptake is limited by higher revision rates compared with total knee arthroplasties (TKA) and concerns over subsequent poor function. The aim of this study was to understand the revision strategies and clinical outcomes for aseptic, failed UKAs at a high-volume centre., Methods: This was a retrospective, single-centre cohort study of 48 patients (31 female, 17 male) with 52 revision UKAs from 2006 to 2018. Median time to revision was 67 (range 4-180) months. Indications for revision were progression of osteoarthritis (n = 31 knees, 59.6%), unexplained pain (n = 10 knees, 19.2%), aseptic loosening (n = 6 knees, 11.5%), medial collateral ligament incompetence (n = 3 knees, 5.8%) and recurrent bearing dislocation (n = 2 knees, 3.8%). Technical details of surgery, complications and functional outcome were recorded., Results: Failed UKAs were revised to primary TKAs (n = 29 knees, 55.8%), revision TKAs (n = 9 knees, 17.3%), bicompartmental KAs (n = 11 knees, 21.2%), or unicompartmental-to-unicompartmental KAs (n = 3 knees, 5.8%). Median follow up was 81 (range 24-164) months. Four patients (7.7%) died from unrelated causes. No re-revisions were identified. Surgical complications required re-operation in five knees (9.6%). Median Oxford Knee Score at latest follow up was 38 (range 9-48) points and median EQ5D3L index 0.707 (range -0.247 to 1.000)., Conclusions: Aseptic, revision UKA at a high-volume centre had good clinical outcomes. Bicompartmental KA demonstrated excellent function and should be considered an alternative to TKA for progression of osteoarthritis for appropriately trained surgeons., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: One or more authors have received Speakers Bureau fees from Zimmer Biomet and DePuy Synthes. Neither company had any role in the design, conduct or reporting of this study., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
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37. Delayed knee flexion is a safe and effective pathway for Total Knee Replacement.
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Jenkins C, Jackson W, Bottomley N, Price A, Murray D, and Barker K
- Subjects
- Humans, Knee Joint, Range of Motion, Articular, Arthroplasty, Replacement, Knee
- Published
- 2020
- Full Text
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38. Paediatric and adolescent anterior cruciate ligament reconstruction surgery.
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Nogaro MC, Abram SGF, Alvand A, Bottomley N, Jackson WFM, and Price A
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- Adolescent, Anterior Cruciate Ligament Injuries epidemiology, Anterior Cruciate Ligament Reconstruction adverse effects, Anterior Cruciate Ligament Reconstruction statistics & numerical data, Child, Child, Preschool, Databases, Factual statistics & numerical data, Female, Humans, Infant, Infant, Newborn, Male, Reoperation statistics & numerical data, United Kingdom epidemiology, Young Adult, Anterior Cruciate Ligament Injuries surgery, Anterior Cruciate Ligament Reconstruction methods
- Abstract
Aims: Anterior cruciate ligament (ACL) surgery in children and the adolescent population has increased steadily over recent years. We used a national database to look at trends in ACL reconstruction and rates of serious complications, growth disturbance, and revision surgery, over 20 years., Methods: All hospital episodes for patients undergoing ACL reconstruction, under the age of 20 years, between 1 April 1997 and 31 March 2017, were extracted by procedure code from the national Hospital Episode Statistics (HES). Population standardized rates of intervention were determined by age group and year of treatment. Subsequent rates of serious complications including reoperation for infection, growth disturbance (osteotomy, epiphysiodesis), revision reconstruction, and/or contralateral ACL reconstruction rates were determined., Results: Over the 20 year period, 16,125 ACL reconstructions were included. The mean age of patients was 16.9 years (SD 2.0; 27.1% female, n = 4,374/16,125). The majority of procedures were observed in the 15 to 19 years age group. The rate of ACL reconstruction increased 29-fold from 1997 to 1998, to 2016 to 2017. Within 90 days of ACL reconstruction, the rate of reoperation for infection was 0.31% (95% confidence interval (CI) 0.23 to 0.41, n = 50/16,125) and the rate of pulmonary embolism was 0.037% (95%.CI 0.014 to 0.081, n = 6/16,125). Of those with minimum five-year follow-up following ACL reconstruction (n = 7,585), 1.00% of patients subsequently underwent an osteotomy (95% CI 0.79 to 1.25, n = 76/7,585), 0.09% an epiphysiodesis (95% CI 0.04 to 0.19, n = 7/7,585), 7.46% revision ACL reconstruction (95% CI 6.88 to 8.08, n = 566/7,585), and 6.37% contralateral ACL reconstruction (95% CI 5.83 to 6.94, n = 483/7,585)., Conclusion: Rates of paediatric and adolescent ACL reconstruction have increased 29-fold over the last 20 years. Despite the increasing rate in the younger population, the risk of serious complications, including further surgery for growth disturbance is very low. The results of our study provide a point of reference for shared decision making in the management of ACL injury in the paediatric and adolescent population. Cite this article: Bone Joint J 2020;102-B(2):239-245.
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- 2020
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39. Introduction of an innovative day surgery pathway for unicompartmental knee replacement: no need for early knee flexion.
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Jenkins C, Jackson W, Bottomley N, Price A, Murray D, and Barker K
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Longitudinal Studies, Male, Middle Aged, Patient Readmission, Patient Satisfaction, Postoperative Complications epidemiology, Range of Motion, Articular, State Medicine, United Kingdom, Ambulatory Surgical Procedures methods, Arthroplasty, Replacement, Knee methods, Arthroplasty, Replacement, Knee rehabilitation, Minimally Invasive Surgical Procedures methods, Physical Therapy Modalities
- Abstract
Objectives: To evaluate the introduction of an innovative rehabilitation protocol, delaying knee flexion, for patients receiving unicompartmental knee replacement., Design: Longitudinal cohort., Setting: Specialist Orthopaedic Unit within an NHS Foundation Trust., Participants: 669 consecutive patients undergoing unicompartmental knee replacement., Intervention: An innovative rehabilitation protocol, delaying knee flexion., Main Outcome Measures: Length of stay, range of movement, Surgical Satisfaction Questionnaire., Results: There were 669 consecutive primary unilateral unicompartmental knee replacements from September 2016 to February 2018. In total 264 patients (39%) went home on the day of surgery, 253 (38%) on day 1 and 152 (23%) stayed in 2 or more days (range 2 to 28 days). The mean length of stay reduced from 2.6 to 1.2days (median 1day). Mean flexion was 110° (range 30 to 140) at 6 weeks. The surgical satisfaction questionnaire showed that 90% of patients discharged on day 0 were very satisfied with the results of surgery., Conclusion: Many components of traditional care were altered to introduce this protocol. The most important factors were delayed knee flexion providing benefits in terms of early mobilisation with no short term detriment, physiotherapists working late shifts, a consistent message and patient education. It was safe, effective and patient satisfaction was high., (Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2019
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40. Patterns of Compartment Involvement in End-stage Knee Osteoarthritis in a Chinese Orthopedic Center: Implications for Implant Choice.
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Wang WJ, Sun MH, Palmer J, Liu F, Bottomley N, Jackson W, Qiu Y, Weng WJ, and Price A
- Subjects
- Adult, Aged, Aged, 80 and over, Anterior Cruciate Ligament diagnostic imaging, Arthroplasty, Replacement, Knee instrumentation, Arthroplasty, Replacement, Knee statistics & numerical data, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Osteoarthritis, Knee diagnostic imaging, Osteoarthritis, Knee pathology, Radiography, Retrospective Studies, Severity of Illness Index, Arthroplasty, Replacement, Knee methods, Knee Prosthesis, Osteoarthritis, Knee surgery
- Abstract
Objectives: Knee osteoarthritis (OA) is a prevalent disease in the elderly, causing pain and contributing to poor quality of life. Surgical intervention, such as knee arthroplasty, can be used in those with end-stage knee OA. Total knee arthroplasty (TKA) is one of the most common surgical procedures for end-stage knee OA, with promising clinical outcomes. However, a large proportion of patients with isolated compartment OA can be treated with unicompartmental knee arthroplasty (UKA) instead. UKA has shown better patient-reported functional outcomes, and lower mortality and major complication rates than TKA. The percentage of UKA in knee arthroplasty varied in different orthopedic centers, and we believed that the requirement for UKA was underestimated in many centers. A retrospective study was carried out on our Chinese patient population presenting for knee arthroplasty; it aimed to identify the proportion of patients that might be suitable for UKA., Methods: A retrospective cross-sectional study of 155 consecutive patients (168 knees) awaiting TKA for end-stage primary OA was performed. The pattern and grade of OA was recorded from preoperative weight-bearing anteroposterior and non-weight-bearing lateral radiographs. The medial, lateral, patellofemoral compartment was given an individual Kellgren-Lawrence grade on the radiographs, and those grade ≥3 were defined as end-stage OA. The compartments involvement was established then. The integrity of the anterior cruciate ligament (ACL) was determined by the modified Keyes classification on lateral radiographs. The applicability for total or partial knee arthroplasty was determined according to the compartments involvement., Results: Medial compartment involvement was found in 154 (91.7%) knees, while the involvement of the lateral compartment and patellofemoral joint was found in 54 (32.1%) and 57 (33.9%) knees, respectively. Eighty-one (48.2%) of the knees showed medial compartment OA with or without patellofemoral joint involvement, and modified Keyes classification grade 1, indicating an intact ACL, and, hence, potential suitability for medial UKA. Isolated lateral OA indicating possible suitability for lateral UKA was identified in 11 knees (6.5%). No patients showed isolated patellofemoral joint OA. The other 76 (45.2%) knees could be treated by TKA., Conclusions: The medial compartment was the most commonly affected in our Chinese patients indicated for knee arthroplasty. More than half of the patients in this group could be treated by either medial or lateral UKA., (© 2018 Chinese Orthopaedic Association and John Wiley & Sons Australia, Ltd.)
- Published
- 2018
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41. The failing medial compartment in the varus knee and its association with CAM deformity of the hip.
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Palmer JS, Palmer AJ, Jones LD, Kang S, Bottomley N, Jackson WM, Monk AP, Beard DJ, Javaid K, Glyn-Jones S, and Price AJ
- Subjects
- Aged, Case-Control Studies, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Femoracetabular Impingement diagnostic imaging, Genu Varum complications, Osteoarthritis, Knee complications
- Abstract
Background: Since 2011, the knee service at the Nuffield Orthopaedic Centre has been offering a neutralising medial opening wedge high tibial osteotomy (HTO) to a specific group of patients with genu varum and early knee osteoarthritis. An observation was made concerning this group of patients and the presence of CAM deformity at the hip. The aim of this study is to establish whether or not any association exists between the OA phenotype shared by our HTO group and the incidence of CAM deformity at the hip., Methods: A cross-sectional study was designed to estimate the prevalence of CAM-type lesions across different groups of individuals. Our HTO group (n=30) was compared to a pre-arthroplasty group (n=20) and control group (n=20). A total of 70 subjects were identified across the different groups all of whom had long-leg radiographs (LLRs) available for analysis. LLRs were analysed using an in house developed Matlab®-based (Matlab R2009b; MathWorks) software package for hip measurements and MediCAD® (Hectec GmbH, Germany) for lower limb alignment measurements., Results: The HTO group had a significantly higher prevalence of CAM lesions (57%) than both the pre-arthroplasty (40%) and control (30%) groups. This difference was maintained when results were adjusted for potential confounding factors (age, gender and laterality). Across the groups, individuals with tibia vara were more likely to have CAM-deformity of the hip (p=0.021)., Conclusion: Patients with symptomatic early knee OA and varus deformity of the knee have a high prevalence of CAM deformity in the hip., (Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.)
- Published
- 2017
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42. Variations In Good Patient Reported Outcomes After Total Knee Arthroplasty.
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Kiran A, Bottomley N, Biant LC, Javaid MK, Carr AJ, Cooper C, Field RE, Murray DW, Price A, Beard DJ, and Arden NK
- Subjects
- Aged, Arthroplasty, Replacement, Knee psychology, Cohort Studies, Female, Follow-Up Studies, Humans, London, Male, Middle Aged, Osteoarthritis, Knee psychology, Pain, Postoperative Period, Research Design, Surveys and Questionnaires, Symptom Assessment, Time Factors, Arthroplasty, Replacement, Knee methods, Osteoarthritis, Knee surgery, Patient Outcome Assessment, Patient Satisfaction
- Abstract
This study identifies optimal OKS values that discriminate post-operative (TKA) patient satisfaction and determines the variation in threshold values by patient characteristics and expectations. It is the first to identify patient improvement using measures (PoPC) that account for patient's pre-operative symptom severity. Of 365 primary TKA patients from a London district general hospital 84% were satisfied at 12 and 24 months. Whilst the overall OKS thresholds (follow-up, change, PoPC) were stable at 12 months (31, 11, 39.7%) and 24 months (35, 12, 38.9%), patients who were older (≥75years), were underweight/normal (BMI<25), had pre-operative symptom severity (OKS≤15) and expected no pain post-surgery, required a greater (potential) improvement to be classed as satisfied. When reporting good patient outcomes, cohorts should be stratified accordingly., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
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43. Skyline patellofemoral radiographs can only exclude late stage degenerative changes.
- Author
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McDonnell SM, Bottomley NJ, Hollinghurst D, Rout R, Thomas G, Pandit H, Ostlere S, Murray DW, Beard DJ, and Price AJ
- Subjects
- Aged, Aged, 80 and over, Arthrography classification, Arthroplasty, Replacement, Knee, Cartilage, Articular pathology, Disease Progression, Female, Humans, Male, Middle Aged, Osteoarthritis, Knee surgery, Patellofemoral Joint surgery, Arthrography methods, Cartilage, Articular diagnostic imaging, Osteoarthritis, Knee diagnostic imaging, Patellofemoral Joint diagnostic imaging
- Abstract
Accurate preoperative assessment of the patellofemoral joint is especially important in compartment specific knee arthritis. This study aims to show the actual intraoperative grade of patellofemoral cartilage damage that may be reliably detected or excluded by preoperative standard radiographic views. 100 consecutive knees awaiting arthroplasty underwent preoperative lateral and skyline radiographs and were scored using the Ahlback score. Intraoperative cartilage damage was assessed using the Collins score. The sensitivity and specificity were calculated for each grade of cartilage damage. Preoperative anterior knee pain and function were assessed and correlated to the degree of cartilage damage. The lateral radiograph shows poor sensitivity for all grades of disease (0.05-0.23). The skyline shows good sensitivity for grade 4 (large full thickness) damage (0.90) but decreases substantially for grades 1-3 (0.19-0.46). Significantly more people with skyline radiograph joint space narrowing complained of anterior knee pain than those with a normal radiograph (p<0.001). There was only a poor correlation between preoperative anterior pain and intraoperative patellofemoral cartilage damage (r=0.24). The lateral radiograph cannot exclude even large areas of full thickness cartilage damage whereas a normal skyline radiograph can reliably exclude significant (grade 4) patellofemoral disease and should be used in addition to the lateral view., (Copyright © 2009 Elsevier B.V. All rights reserved.)
- Published
- 2011
- Full Text
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44. Radiological features of osteoarthritis of the acromiclavicular joint and its association with clinical symptoms.
- Author
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Pennington RG, Bottomley NJ, Neen D, and Brownlow HC
- Subjects
- Adult, Age Factors, Aged, Aged, 80 and over, Arthroscopy, Female, Humans, Male, Middle Aged, Osteoarthritis surgery, Predictive Value of Tests, Radiography, Risk Factors, Severity of Illness Index, Treatment Outcome, Young Adult, Acromioclavicular Joint, Osteoarthritis complications, Osteoarthritis diagnostic imaging
- Abstract
Purpose: To determine whether increasing age is associated with increased radiological features of osteoarthritis of the acromioclavicular joint (ACJ) in a general population, and whether clinical symptoms correlate with radiological features., Methods: Anteroposterior and axillary shoulder radiographs of 240 patients aged 20 to 80 years were randomly selected. The presence of stigmata of osteoarthritis of the ACJ including sclerosis, cysts, lysis, and osteophytes were recorded, and the width of the ACJ was measured. To determine the correlation between clinical symptoms and radiological features, the same radiological features were assessed for 100 further patients who had undergone either arthroscopic subacromial decompression (ASD) alone (n=50) or ASD plus ACJ excision (n=50, age-matched controls) based on clinical examination., Results: Radiological features of osteoarthritis of the ACJ increased significantly with increasing age but were not related to gender or the side affected. Of the 10 features, only medial acromial sclerosis and superior clavicular osteophytes were more prevalent in patients with ASD plus ACJ excision than in those with ASD alone (p=0.016). The sensitivity, specificity, positive and negative predictive values of these features were poor. Therefore, clinical symptoms were not associated with radiological features of osteoarthritis of the ACJ., Conclusion: Radiological features should only be used as an adjunct in the decision to excise the ACJ. A thorough clinical examination is crucial in the assessment of ACJ pathology.
- Published
- 2008
- Full Text
- View/download PDF
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