246 results on '"Botticelli D"'
Search Results
2. Current trends and status of continuing professional development in implant dentistry in Europe
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Ucer, T. C., Botticelli, D., Stavropoulos, A., and Mattheos, N.
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- 2014
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3. Scientific evidences and clinical opinions: 6
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Botticelli, D.
- Published
- 2013
4. Short Oral CommunicationsEffect of wider implant/abutment mismatching: an histological study in dogs: 070
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Canullo, L, Baffone, G M, Botticelli, D, Pantani, F, Beolchini, M, and Lang, N P
- Published
- 2011
5. Clinical Research CompetitionUse of short implants in single tooth replacement (follow-up 4 years): 064
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Rossi, F, Ricci, E, Marchetti, C, Botticelli, D, and Lang, N
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- 2011
6. Hard tissue characteristics affecting aesthetic outcomes: 001
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Botticelli, D
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- 2010
7. Immediate and delayed loading of fixed dental prostheses supported by single or two splinted implants: A histomorphometric study in dogs
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Cesaretti, G, Lang, N P, Viganò, Paolo, Bengazi, F, Apaza Alccayhuaman, K A, Botticelli, D, University of Zurich, and Botticelli, D
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10068 Clinic of Reconstructive Dentistry ,stomatognathic system ,610 Medicine & health ,3500 General Dentistry - Abstract
To evaluate presumptive differences in osseointegration at implants supporting crowns that are physiologically loaded either immediately or 3 months after installation. All premolars and first molars were extracted bilaterally in six dogs. After 3 months of healing, three implants were installed on the premolar region and two in the molar region in one side of the mandible. Likewise, after another 3 months, five implants were installed in the contralateral side, and impressions were taken bilaterally. Within 48 hours, two single crowns were screwed bilaterally onto two implants in the premolar region, and two splinted crowns reproducing the shape of the first molar were screwed bilaterally onto the implants in the molar region. The mesial implants were used as no-loaded controls. Sacrifices were performed after 3 months, and histological analyses were performed. At the premolar sites, mineralised bone-to-implant contact (MBIC%) was 78.0 ± 4.0% and 70.9 ± 7.9% at the delayed and immediately loaded sites, respectively. This difference was statistically significant. At the control implants, MBIC% was 61.4 ± 14.7% and 63.1 ± 13.1% at the delayed and the immediately loaded sites, respectively. At the molar sites, MBIC% was 79.2 ± 10.9% and 61.1 ± 10.3% at the delayed and immediately loaded sites, respectively. Applying a delayed loading to fixed dental prostheses supported by single or two splinted implants yielded higher proportions of bone-to-implant contact (osseointegration) compared to immediately loaded implants. Moreover, both types of loading protocols yielded a higher rate of osseointegration compared to unloaded implant sites after 3 months following implant installation.
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- 2018
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8. Variables that influence the healing at implants installed immediately after extraction
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Apaza Alccayhuaman Ka, Botticelli D, Iida T, Omori Y, and Kawakami S
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Extraction (chemistry) ,Environmental science ,Biomedical engineering - Published
- 2018
9. Effect on osseointegration of two implant macro-designs:A histomorphometric analysis of bicortically installed implants in different topographic sites of rabbit’s tibiae
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Soto-Penaloza, D, primary, Caneva, M, additional, Vina-Almunia, J, additional, Martin-de-Llano, JJ, additional, Garcia-Mira, B, additional, Penarrocha-Oltra, D, additional, Botticelli, D, additional, and Penarrocha-Diago, M, additional
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- 2019
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10. Immediate and delayed loading of fixed dental prostheses supported by single or two splinted implants: A histomorphometric study in dogs
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Cesaretti, G., primary, Lang, N. P., additional, Viganò, P., additional, Bengazi, F., additional, Apaza Alccayhuaman, K. A., additional, and Botticelli, D., additional
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- 2018
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11. The bone lid technique in lateral sinus lift: a systematic review and meta-analysis
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Schiavon Lucia, Perini Alessandro, Brunello Giulia, Ferrante Giada, Del Fabbro Massimo, Botticelli Daniele, Khoury Fouad, and Sivolella Stefano
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Sinus floor augmentation ,Maxillary sinus ,Bone regeneration ,Medicine ,Dentistry ,RK1-715 - Abstract
Abstract Objective This systematic review aimed at assessing the effect of the repositioned bone lid on bone augmentation in lateral sinus lift in pre-clinical in vivo and clinical studies. Secondary aims were to report on the healing of the bone window and to assess the implant survival rate. Material and methods Animal and human studies comparing lateral maxillary sinus floor elevation in combination or not with the repositioned bone lid were retrieved from MEDLINE (PubMed), Web of Science and Cochrane online library. Studies published in English up to April 2022 and reporting on histological and/or radiographic outcomes were considered. Case reports, case series and reviews were excluded. A hand search was also conducted. Risk of bias was assessed and meta-analysis performed to investigate the effect of the bone lid on new bone formation. Results After screening, 5 animal studies (4 in rabbits, 1 in sheep) and 2 clinical studies (1 RCT, 1 case–control) were included. Meta-analysis confirmed a higher new bone formation in rabbits at 2 and 8 weeks using the bone lid. The two clinical studies investigated lateral sinus lift with concomitant implant placement and reported similar results and high short-term implant success rate in both test and control groups. Conclusions The meta-analysis provided moderate evidence that the repositioned bone lid favored the formation of new bone to a higher extent as compared to resorbable membranes in animal studies. Implant success seems not to be influenced by the technique in the short term.
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- 2022
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12. Plasma of Argon Affects the Earliest Biological Response of Different Implant Surfaces
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Canullo, L., Genova, T., Tallarico, M., Gautier, G., Mussano, F., and Botticelli, D.
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surface energy ,bone cell adhesion ,cell adhesion ,dental implants ,protein adsorption ,UV light - Published
- 2016
13. Sequential Healing at Implants with Different Configuration and Modified Surfaces: An Experimental Study in the Dog
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Schweikert, M. T., Botticelli, D., Sbricoli, L., Antunes, A., Favero, V., and Salata, L. A.
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Animal study ,Bone healing ,Dental Implants ,Wound Healing ,Histology ,Animal ,Gingiva ,SLActive ,Mandible ,Implant dentistry ,Bone ,Early healing ,Implant surface ,Nonsubmerged healing ,Osseointegration ,Animals ,Dental Prosthesis Design ,Dogs ,Models, Animal ,Random Allocation ,Models - Abstract
To evaluate the peri-implant soft and hard tissue adaptation at implants with different modified surfaces and configurations.Six Beagle dogs were used. Mandibular premolars and first molars were extracted bilaterally. After 3 months, full-thickness flaps were elevated, and two different types of trans-mucosal implants (ICX-Gold®, Medentis Medical GmbH, Dernau, Germany and SLActive®, Institute Straumann, Bern, Switzerland) and two different surfaces were randomly installed in the distal regions of one side of the mandible. Abutments were applied, and a nonsubmerged healing was allowed. After 1 month, the procedures were performed in the other side of the mandible, and after a further month, the animals were sacrificed, biopsies were collected, and ground sections prepared for histological examination.Similar results in marginal bone and soft tissues dimensions were observed after 1 month of healing at the two implant systems used, and no major changes could be observed after 2 months of healing. After 1 month, the percentage of new bone was 69.0% and 68.8% at ICX-Gold and SLActive surfaces, respectively. After 2 months, the percentage of new bone was 67.8% and 71.9% at ICX-Gold Medentis and SLActive surfaces, respectively. No statistically significant differences in osseointegration were found.The two implant systems used resulted in similar osseointegration after 1 and 2 months of healing.
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- 2015
14. A volumetric 3-D digital analysis of dimensional changes to the alveolar process at implants placed immediately into extraction sockets
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Szathvary, Isacco, Caneva, M., Bressan, Eriberto, Botticelli, D., and Meneghello, Roberto
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- 2015
15. USE OF 6 MM LONG-IMPLANTS IN FIXED PARTIAL DENTURES IN POSTERIOR SITES (FOLLOW-UP 3-YEARS)
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Rossi F., Botticelli D., RICCI, EMANUELE, MARCHETTI, CLAUDIO, SØREN SCHOU, Rossi F., Ricci E., Marchetti C., and Botticelli D.
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PARTIAL FIXED DENTURES ,SHORT IMPLANTS - Published
- 2012
16. USE OF SHORT IMPLANTS (6 MM) IN FIXED PARTIAL DENTURES IN POSTERIOR SITES. A PROSPECTIVE CLINICAL STUDY WITH A 1-YEAR FOLLOW-UP
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RICCI, EMANUELE, MARCHETTI, CLAUDIO, Rossi F, Botticelli D., NIKLAUS P LANG, Ricci E, Rossi F, Marchetti C, and Botticelli D.
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FIXED PARTIAL DENTURES ,SHORT IMPLANTS - Abstract
in replacing missing teeth, osseointegrated implants have become a viable option, especially in the restoration of partial edentulis. Such situations may require additional and complex surgical interventions to augemt insufficient bone volume. An alternative therapy in situations with limited mounts of bone available is the installation of short implants simplifying the restoration of posterior segments. To evalutate the clinical and radiographic outcome and the survival rate of two 6 mm long implants supporting a fixed partial denture placed in the posterior sites, in partially edentulous patients with a 1-year follow-up. Two splitted short implants (6 mm) with a moderately rough surface loaded early (after 6 weeks) during healing yielded high implant survival rates and moderate loss of bone after 1 year of loading. Longer observation periods are needed to draw more definite conclusions on the reliability of short implants supporting fixed partial dentures in order to avoid complicated bone augmentation procedures.
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- 2011
17. USE OF SHORT IMPLANTS IN SINGLE TOOTH REPLACEMENT (FOLLOW-UP 4 YEARS)
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Rossi F, Botticelli D, Lang N., RICCI, EMANUELE, MARCHETTI, CLAUDIO, NIKLAUS P.LANG, Rossi F, Ricci E, Marchetti C, Botticelli D, and Lang N
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SHORT IMPLANTS - Abstract
In the posterior regions, however, the location of anatomical structures, i.e. inferior alveolar nerve and the maxillary sinus, may limit the availability of a sufficient bone volume to install oral implants. An alternative therapy in situations with limited amounts of bone available is the installation of shorts implants, defined as implants with an intrabony length of 6 mm. Forty SLActive Straumanshort implants were placed in 35 consecutively treated patients. Nineteen implants, 4.1 mm in diameter, and 21 implants, 4.8 mm in diameter, were installed. Implants were loaded after 6 weeks of healing . Implant survival rate, marginal bone loss and resonance frequency analysis (RFA) were evaluated at different intervals. The clinical crown/implant ratio was also calculated. Shorts implants (6 mm) with a moderately rough surface loaded early (after 6 weeks) during healing yielded high implant survival rates and moderate loss of bone after 4 years of loading. Longer observation periods are needed to draw more definitive conclusions on the reliability of short implants supporting single crowns.
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- 2011
18. Plasma of Argon Affects the Earliest Biological Response of Different Implant Surfaces
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Canullo, L., primary, Genova, T., additional, Tallarico, M., additional, Gautier, G., additional, Mussano, F., additional, and Botticelli, D., additional
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- 2016
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19. HEALING OF BUCCAL DEHISCENCE DEFECTS AT IMPLANTS INSTALLED IMMEDIATELY INTO EXTRACTION SOCKETS – AN EXPERIMENTALSTUDY IN DOGS
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Bressan, Eriberto, Sivolella, Stefano, Stellini, Edoardo, Almagro Urrutia, Z., Lang, N. P., and Botticelli, D.
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- 2013
20. Computer-guided implant therapy and soft- and hard-tissue aspects: the Third EAO Consensus Conference 2012
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Sicilia, A., Botticelli, D., Cordaro, L., de Bruyn, H., Derks, J., Hultin, M., Lang, N.P., Linkevicius, T., Palarie, V., Petersson, A., Quirynen, M., Rompen, E., Trulsson, M., van Assche, N., Wismeijer, D., Orale Implantologie en Prothetiek (ORM, ACTA), and Oral Implantology
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Dental Implants ,business.industry ,medicine.medical_treatment ,Dental Implantation, Endosseous ,Mouth Mucosa ,MEDLINE ,Consensus conference ,Dentistry ,Alveolar Ridge Augmentation ,Hard tissue ,Scientific evidence ,Implant placement ,Surgery, Computer-Assisted ,Tooth Extraction ,medicine ,Animals ,Humans ,Narrative review ,Implant ,Tooth Socket ,Oral Surgery ,Dental implant ,business - Abstract
IntroductionThe objectives of this working group were to update the existing knowledge base in computer-guided implant treatment (accuracy and clinical advantages), to search for scientific evidence on the need for keratinized tissue around implants, and to review recent literature in the search for new insights into ridge preservation after tooth extraction.Material and methodsThe literature was systematically searched and critically reviewed. Four manuscripts were prepared, three systematic and one narrative review, that allowed the group to develop evidence-based conclusions, as well as clinical implications and recommendations for future research.ResultsThe results and conclusions of the reviews were presented in the following papers:Van Assche et al. () Accuracy of computer-aided implant placement.Hultin et al. () Clinical advantages of computer-guided implant placement: a systematic review.Wennström & Derks () Is there a need for keratinized mucosa around implants to maintain health and tissue stability?Wang & Lang () Ridge preservation after tooth extraction.The group's consensus statements, clinical implications and implications for future research are presented in this article.
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- 2012
21. Establishment of the epithelial attachment and connective tissue adaptation to implants installed under the concept of 'platform switching': a histologic study in minipigs
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Farronato, D, Santoro, G, Canullo, L, Botticelli, D, Maiorana, C, and n p, Lang
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Swine ,Physiological ,Alveolar Bone Loss ,Epithelial Attachment ,oral implants ,Dental Abutments ,Statistics, Nonparametric ,biologic width ,biologic width, connective tissue adaptation, epithelial attachment, healing, oral implants, platform switching ,Animals ,Nonparametric ,Adaptation ,Bone Resorption ,Miniature ,Dental Implants ,connective tissue adaptation ,platform switching ,Adaptation, Physiological ,Connective Tissue ,Dental Implantation, Endosseous ,Dental Prosthesis Design ,Swine, Miniature ,Statistics ,healing ,Dental Implantation ,Endosseous - Abstract
To validate the "platform switching" concept at oral implants with respect to the preservation of the alveolar crestal bone levels in an animal model.Five minipigs received three implants each with a 0.25 mm implant/abutment mismatch and were placed flush (T(0)), 1 mm below (T(1)) and 1 mm above (T(+1)) the alveolar bony crest, and as a control, one conventionally restored implant placed at the bone level. The implants were randomly inserted flapless into the mandible. Four months after implant insertion, the animals were sacrificed, and undecalcified block sections were obtained and used for histological analyses.The mean values for peri-implant bone resorption were 1.09 ± 0.59 mm (Control), 0.51 (± 0.27 mm, T(0)), 0.50 (± 0.46 mm, T(+1)) and 1.30 (± 0.21 mm, T(-1)), respectively. Statistically significant differences (P0.05) were found among the test (T(0), T(-1)) and the control sites. Control implants presented an average biologic width length of 3.20 mm (± 0.33), with a connective tissue adaptation compartment of 1.29 mm (± 0.53) and an epithelial attachment of 1.91 mm (± 0.71). T(0), T(+1) and T(-1) implants presented with a mean biologic width of 1.97 mm (± 1.20), 2.70 mm (± 1.36) and 2.84 mm (± 0.90), respectively, with a connective tissue adaptation compartment of 1.21 mm (± 0.97), 1.21 mm (± 0.65) and 1.50 mm (± 0.70) and an epithelial attachment of 0.84 mm (± 0.93), 1.66 mm (± 0.88) and 1.35 mm (± 0.44), respectively. Differences between the configurations were mainly associated with the length of the epithelial attachment. The epithelial attachment was significantly longer in the C sites than in T(0) (P=0.014). However, no other differences between configurations were detected.If the implants are positioned at the level of the alveolar bony crest, the platform-switching concept may have a minor impact on the length of the epithelial attachment (0.84 vs. 1.91 mm), while the connective tissue adaptation compartment remains relatively unaffected. Moreover, platform switching resulted in less resorption of the alveolar crest (0.58 mm).
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- 2011
22. Effect of wider implant/abutment mismatching: an histological study in dogs
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Canullo, L, Baffone GM Botticelli, D, Pantani, F, Beolchini, M, and Lang, Np
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platform switching ,animal study ,peri-implant bone level changes - Published
- 2011
23. Flap vs. 'flapless' surgical approach at immediate implants: a histomorphometric study in dogs
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Caneva, M, Botticelli, D, Salata, La, Souza, Sl, Bressan, Eriberto, and Lang, Np
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Dental Implants ,Photomicrography ,Dogs ,Connective Tissue ,Dental Implantation, Endosseous ,Alveolar Process ,Epithelial Attachment ,Gingiva ,Animals ,Dental Abutments ,Tooth Socket ,Surgical Flaps - Abstract
To compare the remodeling of the alveolar process at implants installed immediately into extraction sockets by applying a flap or a "flapless" surgical approach in a dog model.Implants were installed immediately into the distal alveoli of the second mandibular premolars of six Labrador dogs. In one side of the mandible, a full-thickness mucoperiosteal flap was elevated (control site), while contra-laterally, the mucosa was gently dislocated, but not elevated (test site) to disclose the alveolar crest. After 4 months of healing, the animals were sacrificed, ground sections were obtained and a histomorphometric analysis was performed.After 4 months of healing, all implants were integrated (n=6). Both at the test and at the control sites, bone resorption occurred with similar outcomes. The buccal bony crest resorption was 1.7 and 1.5 mm at the control and the test sites, respectively."Flapless" implant placement into extraction sockets did not result in the prevention of alveolar bone resorption and did not affect the dimensional changes of the alveolar process following tooth extraction when compared with the usual placement of implants raising mucoperiosteal flaps.
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- 2010
24. Immediate implant placement with transmucosal healing in areas of aesthetic priority: A multicentre randomized-controlled clinical trial I. Surgical outcomes
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Lang, N.P. Tonetti, M.S. Suvan, J.E. Bernard, J.P. Botticelli, D. Fourmousis, I. Hallund, M. Jung, R. Laurell, L. Salvi, G.E. Shafer, D. Weber, H.-P.
- Abstract
Objectives: To compare the clinical outcomes of standard, cylindrical, screw-shaped to novel tapered, transmucosal (Straumann Dental®) implants immediately placed into extraction sockets. Material and methods: In this randomized-controlled clinical trial, outcomes were evaluated over a 3-year observation period. This report deals with the need for bone augmentation, healing events, implant stability and patient-centred outcomes up to 3 months only. Nine centres contributed a total of 208 immediate implant placements. All surgical and post-surgical procedures and the evaluation parameters were discussed with representatives of all centres during a calibration meeting. Following careful luxation of the designated tooth, allocation of the devices was randomly performed by a central study registrar. The allocated SLA titanium implant was installed at the bottom or in the palatal wall of the extraction socket until primary stability was reached. If the extraction socket was ≥1 mm larger than the implant, guided bone regeneration was performed simultaneously (Bio Oss® and BioGide®). The flaps were then sutured. During non-submerged transmucosal healing, everything was done to prevent infection. At surgery, the need for augmentation and the degree of wound closure was verified. Implant stability was assessed clinically and by means of resonance frequency analysis (RFA) at surgery and after 3 months. Wound healing was evaluated after 1, 2, 6 and 12 weeks post-operatively. Results: The demographic data did not show any differences between the patients receiving either standard cylindrical or tapered implants. All implants yielded uneventful healing with 15% wound dehiscences after 1 week. After 2 weeks, 93%, after 6 weeks 96%, and after 12 weeks 100% of the flaps were closed. Ninety percent of both implant designs required bone augmentation. Immediately after implantation, RFA values were 55.8 and 56.7 and at 3 months 59.4 and 61.1 for cylindrical and tapered implants, respectively. Patient-centred outcomes did not differ between the two implant designs. However, a clear preference of the surgeon's perception for the appropriateness of the novel-tapered implant was evident. Conclusions: This RCT has demonstrated that tapered or standard cylindrical implants yielded clinically equivalent short-term outcomes after immediate implant placement into the extraction socket. © 2007 Blackwell Munksgaard.
- Published
- 2007
25. Implant removal by means of an expansion of the alveolar bony crest: report of a clinical technique
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Beolchini, M., primary, Lilliu, S., additional, Faria, P., additional, and Botticelli, D., additional
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- 2012
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26. Bisphosphonate-associated osteonecrosis of the jaw 2 years after teeth extractions: a case report solved with non-invasive treatment.
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GÓMEZ-MORENO, G., ARRIBAS-FERNÁNDEZ, M. C., FERNÁNDEZ-GUERRERO, M., BOQUETE-CASTRO, A., AGUILAR-SALVATIERRA, A., GUARDIA, J., BOTTICELLI, D., and CALVO-GUIRADO, J. L.
- Abstract
Bisphosphonates are a type of drugs known to inhibit bone resorption through complex interventions.Their primary mechanism of action is aimed at the cellular level, inhibiting osteoclast activity and, thus, bone resorption. Bisphosphonates are, therefore, very widely used, with many patients receiving continuous treatment for years. But it is well known that these drugs can produce osteonecrosis of the jaw and this is their principal risk. A 75-year-old woman received dental treatment before starting intravenous BP therapy for a breast cancer. She started intravenous bisphosphonate treatment with monthly protocol and after two years the patient presented a wound compatible with osteonecrosis of the jaw. [ABSTRACT FROM AUTHOR]
- Published
- 2014
27. Histological and Histomorphometric Comparison of Innovative Dental Implants Laser Obtained: Animal Pilot Study
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Mastrangelo Filiberto, Botticelli Daniele, Bengazi Franco, Scarano Antonio, Piattelli Adriano, Iezzi Giovanna, and Quaresima Raimondo
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laser treatment ,dental implants ,sandblasted and acid etching implant ,sheep animal model ,histological and histomorphometrical analysis ,bone to implant contact (BIC) ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Objective: Evaluation of the in vivo bone response of two innovative titanium surfaces ytterbium laser active fiber obtained (L1-L2) compared to a sandblasted and acid etched (SBAE) during early phase of osseointegration. Material and Methods: Three implant groups with the same macroscopic features were obtained (L1-L2-SBAE) to promote specific surface characteristics. Scanning electron microscopy, profilometric evaluation, X-ray spectrometry, and diffraction analysis were performed. For each group, six implants were placed in the tibiae of three Peli Buey sheep, and histologic, histomorphometric analysis, bone to implant contact (BIC), and the Dynamic Osseointegration index (DOI) were performed. Results: During the early phases of osseointegration, the histological and histomorphometric results showed significant differences between L1-L2-SBAE implants. At 15 and 30 days, histological analysis detected a newly bone formation around all specimens with an higher vital bone in L2 compared to L1 and SBAE both in cortical and in poor-quality marrow bone. At same time, histomorphometric analysis showed significantly higher BIC values in L2 (42.1 ± 2.6 and 82.4 ± 2.2) compared to L1 (5.2 ± 3.1 and 56.2 ± 1.3) and SBAE (23.3 ± 3.9 and 77.3 ± 0.4). DOI medium value showed a higher rate in L2 (2.83) compared to SBAE (2.60) and L1 (1.91). Conclusions: With the limitations of this pilot study, it is possible to assess that the titanium surface characteristics, and not the technologies used to obtain the modification, played a crucial role during the osseointegration process. Histological, histomorphometric, BIC, and DOI evaluation showed a significantly higher rate in L2 specimens compared to others, confirming that the implant surface could increase the bone response in cortical or marrow poor quality bone during the initial phases of osseointegration.
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- 2021
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28. Factors Affecting Soft and Hard Tissues Around Two-Piece Transmucosal Implants: A 3-Year Prospective Cohort Study
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Chiara Pirani, Fausto Zamparini, Carlo Prati, Luigi Canullo, Daniele Botticelli, Maria Giovanna Gandolfi, Prati C., Zamparini F., Canullo L., Pirani C., Botticelli D., and Gandolfi M.G.
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Male ,medicine.medical_treatment ,Radiography ,Bleeding on probing ,Dentistry ,Esthetics, Dental ,hyperbolic neck ,Bone tissue ,single implant ,Crown (dentistry) ,03 medical and health sciences ,Dental Implants, Single-Tooth ,0302 clinical medicine ,medicine ,Humans ,Single-Blind Method ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Survival rate ,prospective cohort study ,transmucosal placement ,business.industry ,Dental Implantation, Endosseous ,Soft tissue ,030206 dentistry ,General Medicine ,Middle Aged ,Dental Implantation, Endosseou ,flapless procedure ,Prospective Studie ,medicine.anatomical_structure ,Female ,Implant ,Oral Surgery ,medicine.symptom ,business ,Human - Abstract
Purpose:This 3-year study aimed to evaluate hard and soft tissue modification around a two-piece implant characterized by a transmucosal hyperbolic neck in healthy consecutive patients with a need for single-tooth replacement. Materials and Methods: Two-piece implants (n = 66) were placed with a flapless technique in 56 patients (27 men; 29 women; mean age 55 ± 9 years): 16 immediately after root extraction (immediate group), 20 after 8 to 12 weeks (early group), and 30 after 10 or more months (delayed group). The transmucosal hyperbolic neck was exposed 1 to 1.5 mm above gingival level. Customized abutments were positioned 3 months later with the implant-abutment connection located approximately 1 to 1.5 mm above soft tissue level. Provisional cemented resin crowns were designed with the finishing line at the hyperbolic neck and then positioned to avoid excessive compression of soft tissue, to guide gingival contours. Twenty days later, a definitive metal-ceramic crown was cemented. In all patients, the gingival biotype (thin or thick) was also evaluated. The primary outcomes were as follows: 36-month implant survival rate, peri-implant marginal bone level (MBL, in mm) changes observed in single-blind on radiographs at 1, 3, 6, 12, 24, and 36 months (T1, T3, T6, T12, T24, and T36), and pink esthetic score (PES) at T6, T12, and T36 to analyze soft tissue adaptation after loading and crown application. The secondary outcomes were as follows: plaque score and bleeding on probing (BOP). Linear regression models and multilevel mixed logistic regression were used to detect any statistical difference of MBL according to operative parameters. Kruskal-Wallis one-way analysis of variance (ANOVA) on ranks was performed to assess statistical differences of PES at T6, T12, and T36. Results: The survival rate was 100%. The dropout rate was 1.79%. No infections, mucositis, or peri-implantitis were reported. Implants placed in thick-biotype tissues showed a statistically different lower bone loss at 36 months with respect to the thin biotype (P
- Published
- 2020
29. Two-year follow-up of 4-mm-long implants used as distal support of full-arch fdps compared to 10-mm implants installed after sinus floor elevation. A randomized clinical trial
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Daniele Botticelli, Fabio Rossi, Lorenzo Ferraioli, Gerardo Pellegrino, Pietro Felice, Emanuele Ricci, Andreea Suerica, Lorenzo Tuci, Rossi F., Tuci L., Ferraioli L., Ricci E., Suerica A., Botticelli D., Pellegrino G., and Felice P.
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full arch fixed dental prostheses ,Sinus Floor Augmentation ,Health, Toxicology and Mutagenesis ,medicine.medical_treatment ,Dentistry ,lcsh:Medicine ,Full edentulism, posterior atrophies, short dental implants, sinus lift ,Prosthesis ,Bone resorption ,Article ,03 medical and health sciences ,0302 clinical medicine ,Maxilla ,Medicine ,Humans ,030212 general & internal medicine ,Dental Restoration Failure ,Survival rate ,Sinus (anatomy) ,Dental alveolus ,business.industry ,lcsh:R ,Public Health, Environmental and Occupational Health ,030206 dentistry ,Alveolar Ridge Augmentation ,Prostheses and Implants ,medicine.anatomical_structure ,Treatment Outcome ,sinus floor elevation ,Implant ,short implants ,business ,Follow-Up Studies - Abstract
Background: In edentulous patients, bone resorption cannot allow the installation of standard implants and it is demanded to use short implants in the residual alveolar bone or longer implants in grafted bone. Aim: To compare the survival and bone level changes of standard plus short 4-mm implants used as distal support of a maxillary full-arch fixed dental prostheses (FDPs) with standard (10-mm) implants placed in association with a bilateral sinus floor augmentation procedure. Material and Methods: Full-arch FDPs supported by six implants were randomly placed in both groups. In the control group, all implants were 10 mm long and 4.1 mm in diameter. The distal implant in both sides of the maxilla was installed after 4 months from bilaterally sinus floor elevation. In the test group (short group), the distal implant in both sides of the maxilla was 4 mm long and 4.1 mm in diameter. No sinus floor elevations were performed in the test group. Clinical assessments and X-rays were taken at prosthesis delivering and after 6, 12, 18, and 24 months. Patient-reported outcome measures (PROMs) were also evaluated before surgery and after 6, 12, and 24 months. Results: The changes over time of the bone level for the short implants were −0.01 ± 0.11 mm, −0.04 ± 0.13 mm, −0.17 ± 0.29 mm, and −0.28 ± 0.37 mm after 6, 12, 18, and 24 months from prosthesis delivering, respectively. For the standard implants, bone changes were −0.21 ± 0.33 mm (p = 0.103), −0.30 ± 0.32 mm (p = 0.023), −0.40 ± 0.37 mm (p = 0.144), and −0.54 ± 0.49 mm (p = 0.128), respectively. A statistically relevant difference was found only at 12 months after loading between the two groups. Conclusions: Similar results on implant survival rate and marginal bone loss were observed for the short and standard implants, placed in association with a bilateral sinus floor augmentation procedure, used as distal support of a maxillary full-arch FDP. A statistically relevant difference was found only at 12 months after loading between the two groups (p = 0.023).
- Published
- 2021
30. Early loading of 6-mm-short implants with a moderately rough surface supporting single crowns--a prospective 5-year cohort study
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Daniele Botticelli, Claudio Marchetti, Fabio Rossi, Niklaus P. Lang, Lorenzo Ferraioli, Emanuele Ricci, Rossi F, Lang NP, Ricci E, Ferraioli L, Marchetti C, and Botticelli D.
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Adult ,Male ,Immediate Dental Implant Loading ,Surface Properties ,medicine.medical_treatment ,Radiography ,Abutment ,Dentistry ,SHORT IMPLANTS ,Prosthesis ,Crown (dentistry) ,Dental Implants, Single-Tooth ,medicine ,Humans ,Prospective Studies ,Survival rate ,Aged ,Crowns ,business.industry ,Middle Aged ,Resonance frequency analysis ,Treatment Outcome ,Dental Prosthesis Design ,Torque ,early loading ,Female ,Implant ,Dental Prosthesis, Implant-Supported ,Oral Surgery ,business ,Cohort study - Abstract
AIM: To evaluate prospectively the clinical and radiographic outcomes after 5 years of early loading of 6-mm implants with a moderately rough (SLActive(®) ) surface supporting single crowns in the posterior regions. MATERIAL AND METHODS: Thirty-five consecutive patients received 40 SLActive(®) (Straumann) 6-mm implants with a diameter of 4.1 mm (n = 19) or 4.8 mm (n = 21). Insertion torque and resonance frequency analysis (RFA) were measured at implant installation. RFA was also measured at abutment connection. SynOcta abutments were tightened with 35 Ncm after 6 weeks of healing, and single porcelain fuse to metal crowns was cemented within 1 week. Implant survival rate and marginal bone loss were evaluated at various time intervals until 5 years after loading. The clinical crown/implant ratio was calculated as well. RESULTS: Two of 40 implants were lost before loading (incorporation rate 95%), and no further implant loss or technical complications were encountered during the 5-year follow-up period. A mean marginal bone loss of 0.7 ± 0.6 mm was found after 5 years of function. The clinical crown/implant ratio increased with time from 1.6 at the delivery of the prosthesis to 2 after 5 years of loading. CONCLUSION: Six millimeter implants with a SLActive(®) moderately rough surface supporting single crowns in the posterior region and loaded after 6-7 weeks maintained full function for at least 5 year with low marginal bone resorption.
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- 2014
31. Early loading of single crowns supported by 6-mm-long implants with a moderately rough surface: a prospective 2-year follow-up cohort study
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Fabio Rossi, Daniele Botticelli, Niklaus P. Lang, Claudio Marchetti, Emanuele Ricci, Rossi F, Ricci E, Marchetti C, Lang NP, and Botticelli D
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Adult ,Male ,Surface Properties ,Alveolar Bone Loss ,Dentistry ,Dental Abutments ,SHORT IMPLANTS ,Bite Force ,Cohort Studies ,Osseointegration ,Early loading ,Humans ,Medicine ,Dental Restoration Failure ,Prospective Studies ,Prospective cohort study ,Aged ,Dental Implants ,Crowns ,business.industry ,Middle Aged ,Survival Analysis ,Radiography ,Short implants ,Treatment Outcome ,Dental Prosthesis Design ,Rough surface ,Elasticity Imaging Techniques ,Female ,Dental Prosthesis, Implant-Supported ,Periodontal Index ,Oral Surgery ,business ,Follow-Up Studies ,Cohort study - Abstract
Aim: To evaluate prospectively the clinical and radiographic outcomes after 2 years of loading of 6 mm long moderately rough implants supporting single crowns in the posterior regions. Material and methods: Forty SLActive Straumann((R)) short (6 mm) implants were placed in 35 consecutively treated patients. Nineteen implants, 4.1 mm in diameter, and 21 implants, 4.8 mm in diameter, were installed. Implants were loaded after 6 weeks of healing. Implant survival rate, marginal bone loss and resonance frequency analysis (RFA) were evaluated at different intervals. The clinical crown/implant ratio was also calculated. Results: Two out of 40 implants were lost before loading. Hence, the survival rate before loading was 95%. No further technical or biological complications were encountered during the 2-year follow-up. The mean marginal bone loss before loading was 0.34+/-0.38 mm. After loading, the mean marginal bone loss was 0.23+/-0.33 and 0.21+/-0.39 mm at the 1- and 2-year follow-ups. The RFA values increased between insertion (70.2+/-9) and the 6-week evaluation (74.8+/-6.1). The clinical crown/implant ratio increased with time from 1.5 at the delivery of the prosthesis to 1.8 after 2 years of loading. Conclusion: Short implants (6 mm) with a moderately rough surface loaded early (after 6 weeks) during healing yielded high implant survival rates and moderate loss of bone after 2 years of loading. Longer observation periods are needed to draw more definite conclusions on the reliability of short implants supporting single crowns.
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- 2010
32. Critical-sized marginal defects around implants in the rabbit mandible.
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Morimoto A, Porfirio Xavier S, Ricardo Silva E, Morinaga K, Botticelli D, Nakajima Y, and Baba S
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- Animals, Rabbits, Bone Regeneration physiology, Wound Healing physiology, Dental Implantation, Endosseous, Mandible surgery, Dental Implants
- Abstract
Background: The mandible of the rabbit is considered a reliable model to be used to study bone regeneration in defects. The aim of the present study was to evaluate the formation of new bone around implants installed in defects of either 5 or 10 mm in the mandible of rabbits., Materials and Methods: In 12 rabbits, 3 mm deep circumferential defect, either 5 or 10 mm in diameter, were prepared bilaterally and an implant was placed in the center. A collagen membrane was placed to close the entrance. After 10 weeks, biopsies were taken, histological slides were prepared, and different regions of the defects were analyzed., Results: Similar amounts of new bone were found in both defects. However, most of the 5 mm defects were filled with new bone. New bone was observed closing the entrance of the defect and laid onto the implant surface. Only in a few cases the healing was incomplete. Despite a similar percentage of new bone found within the 10 mm defects, the healing was incomplete in most of the cases, presenting a low rate of bone formation onto the implant surface within the defect. Only one case presented the closure of the entrance., Conclusions: The dimensions of the defect strongly influenced the healing so that a circumferential marginal defect of 10 mm around an implant in the mandible body should be considered a critical-sized defect. The presence of the implant and of residues of teeth might have strongly influenced the healing., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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33. Influence on marginal bone levels at implants equipped with blades aiming to control the lateral pressure on the cortical bone. An experimental study in dogs.
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Kanayama M, Ferri M, Guzon FMM, Asano A, Alccayhuaman KAA, Rossi EF, and Botticelli D
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- Animals, Dogs, Alveolar Bone Loss prevention & control, Alveolar Process surgery, Osteotomy instrumentation, Pressure, Osseointegration physiology, Equipment Design, Cortical Bone, Dental Implants, Dental Implantation, Endosseous, Mandible surgery
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Background: To avoid cortical compression, several implant systems have included in the protocol dedicated drills aimed at widening the cortical region of osteotomy. However, the manual execution of this operation does not guarantee the necessary precision. Hence, the present study aimed to determine the optimal size of the recipient site at the level of the alveolar crest in relation to the size of the coronal region of the implant to achieve the best healing result., Materials and Methods: Blades of different diameters were incorporated into the coronal part of the implant to prepare the cortical region of the mandibular alveolar bone crest in different dimensions in relation to the collar of the implant. The differences in diameter of the blades in relation to the collar of the implant were as follows: one control group, -175 μm, and three test groups, 0 μm, + 50 μm, or + 200 μm., Results: The marginal bone loss (MBL) at the buccal aspect was 0.7 mm, 0.5 mm, 0.2 mm, and 0.7 mm in the - 175 μm, 0.0 μm, + 50 μm, + 200 μm groups, respectively. The differences were statistically significant between group + 50 μm and control group - 175 μm (p = 0.019), and between + 50 μm and + 200 μm (p < 0.01) groups. The level of osseointegration at the buccal aspect was more coronally located in the test groups than in the control group, whereas the bone-to-implant contact percentage was higher in the + 50 μm and + 200 μm groups. However, these differences were not statistically significant., Conclusions: The lowest bone crest resorption and highest levels of osseointegration were observed in the 0.0 μm and + 50 μm groups. The cortical region where the blades had performed their cutting action showed regular healing with perfect hard and soft tissues sealing in all the groups. Cortical blades gathered bone particles, particularly in the + 200 μm group, which were incorporated into the newly formed bone. The results from the present experiment provide support to the use of blades that produce a marginal gap of 50 μm after implant insertion., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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34. Controlled Lateral Pressure on Cortical Bone Using Blade-Equipped Implants: An Experimental Study in Rabbits.
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Ferreira Balan V, Ferri M, Pires Godoy E, Artioli LG, Botticelli D, Silva ER, and Xavier SP
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Background: This study aimed to evaluate the biological behavior of a novel implant design incorporating decompressive cervical blades. Hence, the aim of the present study was to evaluate the healing outcomes in cortical regions where decompressive protocols were implemented using implants equipped with blades and installed applying a bicortical anchorage., Materials and Methods: Blades with varying diameters were integrated into the coronal portion of the implant to prepare the cortical region of rabbit tibiae. The blade diameters differed from the implant collar by the following amounts: control group (0 µm), +50 µm, and +200 µm., Results: No marginal bone loss was detected. Instead, all implants exhibited new bone formation in the coronal region. Complete closure was observed in the CG-0 group, as well as in the TG-50 and TG-200 groups, despite the presence of marginal gaps without primary bone contact at installation. In the apical region, most implants breached the cortical layer. Nevertheless, new bone formation in this region completely closed the osteotomy, effectively isolating the internal environment of the tibia from the external., Conclusions: The use of a blade incorporated into the implant body enabled precise preparation of the cortical layer, allowing for controlled decompression in the targeted area. This technique resulted in optimal osseointegration with no loss of marginal bone, and complete restoration of marginal gaps ranging from 0 µm to 200 µm.
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- 2024
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35. An Enigmatic Soft-Tissue Creeping Phenomenon: The Spontaneous Peri-Implant Mucosa Margin and Papilla Growth, Part Two-A Scientifically Supported Hypothesis Article.
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Agabiti I, Apaza Alccayhuaman KA, Taniguchi Z, Kuwano K, and Botticelli D
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In our previous article, we observed and measured a spontaneous growth in the coronal direction of the keratinized tissues present around implants. This growth involved both free margins and interdental papillae, and we indicated our hypothesis on the probable cause of this still-unexplained phenomenon. The growth of oral soft tissues involves several other structures, such as the linea alba and tongue indentation. Our idea holds that growth of these tissues is generated by the negative intraoral pressure created in the oral phase of swallowing and the subsequent resting position, which through the resulting suction causes a shift of these soft structures in the gaps around the dental crowns. Other hypotheses have been suggested in the past to understand this phenomenon of soft tissue growth, which still lacks data supporting etiological evidence. The purpose of this article is to thoroughly analyze and verify our model by comparing the clinical observations with citations and examples from the literature, combined with notions of physiology, biology, and physics that help in clarifying these events. To better explain the mechanisms of oral soft tissue growth, photographs of clinical cases paradigmatic of the phenomenon are shown.
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- 2024
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36. Evaluation of a New Simplified Approach for Upper Superficial Impacted Third Molar Extraction-A Retrospective Split-Mouth Study.
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Materni A, Apaza Alccayhuaman KA, Maltagliati A, Botticelli D, and Benedicenti S
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Background: A new access technique was developed to reduce postoperative adverse events after the extraction of impacted maxillary wisdom teeth. Hence, this study aimed to assess the occurrence of adverse events after the extraction of maxillary impacted wisdom teeth using a traditional access (TA) or a new technique (NT)., Methods: Two different surgical incision designs were used for bilateral wisdom tooth extractions in 30 patients. The traditional incision was performed distal to the second molar in the center of the tuberosity, followed by a buccal releasing incision. After the tooth extraction, the wound was secured by sutures. The new technique consists of an oblique incision from the distal palatal aspect of the tuberosity towards the buccal aspect of the second molar. After the tooth extraction, cyanoacrylate glue was used on the wound., Results: Lower pain was reported by patients at the site treated with the new technique ( p < 0.01). Edema, postsurgical bleeding, and hematoma were similar in both groups. The surgical time was shorter for the new technique ( p < 0.01)., Conclusions: The new technique applied for the extraction of impacted maxillary wisdom teeth reduced postsurgical pain and the duration of surgery.
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- 2024
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37. Mineralization and morphology of peri-implant bone around loaded and unloaded dental implants retrieved from the human mandible.
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Zamparini F, Gandolfi MG, Spinelli A, Ferri M, Iezzi G, Botticelli D, and Prati C
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- Humans, Female, Male, Microscopy, Electron, Scanning, Calcium analysis, Middle Aged, Phosphorus, Aged, Spectrometry, X-Ray Emission, Dental Implantation, Endosseous methods, Nitrogen, Mandible surgery, Dental Implants, Calcification, Physiologic physiology
- Abstract
Purpose: Limited data is reported regarding the bone mineralization around dental implants in the first months from insertion. The study analyzed the peri-implant bone around loaded and unloaded implants retrieved from human mandible after 4 months from placement., Method: The composition and mineralization of human bone were analyzed through an innovative protocol technique using Environmental-Scanning-Electron-Microscopy connected with Energy-Dispersive-X-Ray-Spectroscopy (ESEM/EDX). Two regions of interest (ROIs, approximately 750×500 μm) for each bone implant sample were analyzed at the cortical (Cortical ROI) and apical (Apical ROI) implant threads. Calcium, phosphorus, and nitrogen (atomic%) were determined using EDX, and the specific ratios (Ca/N, P/N, and Ca/P) were calculated as mineralization indices., Results: Eighteen implant biopsies from ten patients were analyzed (unloaded implants, n=10; loaded implants, n=8). For each ROI, four bone areas (defined bones 1-4) were detected. These areas were characterized by different mineralization degree, varied Ca, P and N content, and different ratios, and by specific grayscale intensity detectable by ESEM images. Bony tissue in contact with loaded implants at the cortical ROI showed a higher percentage of low mineralized bone (bone 1) and a lower percentage of remodeling bone (bone 2) when compared to unloaded implants. The percentage of highly mineralized bone (bone 3) was similar in all groups., Conclusion: Cortical and apical ROIs resulted in a puzzle of different bone "islands" characterized by various rates of mineralization. Only the loaded implants showed a high rate of mineralization in the cortical ROI., (© 2023. The Author(s).)
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- 2024
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38. Critical-sized marginal defects around implants treated with xenografts in rabbits.
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Asano A, Xavier SP, Silva ER, Morinaga K, Botticelli D, Nakajima Y, and Baba S
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- Animals, Rabbits, Cattle, Minerals therapeutic use, Wound Healing physiology, Bone Substitutes therapeutic use, Dental Implantation, Endosseous, Collagen, Osteogenesis physiology, Osteogenesis drug effects, Osseointegration physiology, Heterografts, Mandible surgery, Dental Implants
- Abstract
Background: Healing of critical-size defects is a well-known problem that has been challenged in several studies. The aim of the experiment was to evaluate bone formation and osseointegration of implants installed in critical defects of the mandibular body simultaneously grafted with Bio-Oss® or Cerabone®., Material and Methods: Defects, 10 mm wide and 3 mm deep, were prepared at both lateral aspects of the mandible in 12 rabbits. One implant was installed in the center of the defect, and bovine xenografts produced either at low (Bio-Oss®; Low-T) or high (Cerabone®; High-T) temperatures were used to fill the defects. A collagen membrane was placed to cover the sites. Healing was evaluated 10 weeks after surgery., Results: In both groups, most sites showed optimal healing with closure of the coronal entrance of the defects. However, residual defects occupied by soft tissues and biomaterial particles were observed, even though generally limited to some regions of the defect. Osseointegration of the implant surface in the region of the defect was poor in both groups., Conclusions: Circumferential marginal critical-size defects around implants filled with bovine xenografts presented regions with a complete healing in both groups. However, the healing was not complete at all regions in most defects; therefore, a complete optimal healing of critical-size marginal defects cannot be predicted., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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39. Application of the break-even point to express the bone dynamics around implants.
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Hori Y, Amari Y, Ohnishi H, Seo H, Chi YC, Botticelli D, Xavier SP, and Baba S
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- Humans, Dogs, Animals, Bone Resorption, Osseointegration physiology, Bone Remodeling physiology, Maxilla surgery, Dental Implantation, Endosseous, Bone Density, Dental Implants, Osteogenesis physiology
- Abstract
Purpose: The aim of this study was to apply the break-even point concept to express the dynamics of bone formation and resorption around implants., Methods: Published data on new bone and parent bone densities around implants from one human and three dog studies were selected and used for analysis. The break-even point (BEP) of the bone density (BD) was assessed. The BEP is the point at which, in a graph, the lines representing the formation of new bone and resorption of old bone intersect. BEP is expressed in time (x; days) of occurrence and percentage of bone (y; %) at which the break-even point occurs and illustrates the grade of bone modeling. The sooner the occurrence, the faster the bone formation in relation to the resorption of the old bone., Results: In the marrow and cortical compartments, BEP of bone density occurred after 7.9 days (BD% 24.5%) and >30 days, respectively. Different surfaces presented similar BEP, ranging between 9.7 and 11.2 days (BD% 19.1-22.5%). BEP at implants installed in the human maxilla occurred after 29-30.4 days (BD% 28.3-29.6%)., Conclusion: The present study showed that the parameters used to express the break-even point can provide information on the influence of the model used, surface characteristics, and bone quality on bone modeling/remodeling around implants., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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40. Correction: Omori et al. Sinus Mucosal Damage Triggered by Synthetic or Xenogeneic Bone Substitutes: A Histological Analysis in Rabbits. J. Funct. Biomater. 2022, 13 , 257.
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Omori Y, Botticelli D, Migani S, Ferreira Balan V, Pires Godoy E, and Xavier SP
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In the original publication [...].
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- 2024
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41. Alveolar Buccal Bone Overbuilding Before Tooth Extraction: A Preclinical Study.
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Iida T, Miki M, Ferri M, Guzon FMM, Cesaretti G, and Botticelli D
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Background: After tooth extraction, a physiological shrinkage of the alveolar ridge occurs. Applying a buccal overbuilding some months before tooth extraction may create a stiffer hard tissue that might protect the alveolar crest from resorption. Hence, the aim of this experiment was to evaluate the dimensional changes in the alveolar crest after buccal overbuilding performed before tooth extraction., Materials and Methods: At the test sites, an alveolar crest overbuilding was performed on the buccal aspect of the distal root of the third premolar using xenograft covered with a collagen membrane. No treatment was applied at the control sites. After 3 months, the distal roots of both third premolars were extracted and implants were immediately installed into the alveolus allowing a non-submerged healing. After 3 months, biopsies were collected., Results: At the histological analyses, no statistically significant differences in hard tissue dimensions were found. The buccal bone plate at the test sites presented a tendency of higher resorption compared to the control sites. However, if the contribution of the residues of biomaterial was considered, a higher volumetric gain was registered at the test than at the control sites., Conclusions: The buccal overbuilding performed before tooth extraction did not contribute to the preservation of the alveolar crest dimensions after extraction. This could be due to failure to incorporate the graft into the newly formed bone.
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- 2024
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42. Variables Influencing Bone Formation After Transcrestal Sinus Floor Elevation: Radiographic and Tomographic Evaluations.
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Mainetti G, Mainetti T, Bengazi F, De Rossi EF, Alccayhuaman KAA, and Botticelli D
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- Humans, Biocompatible Materials, Bone Matrix, Osteogenesis, Sinus Floor Augmentation
- Abstract
Purpose: To evaluate the influence of initial implant protrusion within the subantral space on hard tissue gain for implants placed simultaneously with transcrestal sinus floor elevation (TSFE) with a biomaterial., Materials and Methods: A total of 50 implants were placed after TSFE in 44 patients using either a human demineralized bone matrix or a deproteinized bone mineral matrix. Intraoral radiographs were obtained before and immediately after surgery. CBCT scans were obtained at the last follow-up (mean: 6.6 years)., Results: The initial bone crest height was 4.6 ± 1.4 mm, and the initial protrusion of the implants above the sinus floor was 3.5 ± 1.4 mm. At the follow-up assessments, the hard tissue mean gain was 2.5 ± 1.5 mm, resulting in a mean residual protrusion of 1.1 ± 1.3 mm. Only 10 implants did not protrude above the apical level of hard tissue. Positive correlations were found between hard tissue gain and initial protrusion (r = 0.55; 95% CI: 0.32 to 0.72; P = .0001), between the initial and final protrusions (r = 0.38; 95% CI: 0.10 to 0.60; P = .007), and between the follow-up period and final protrusion (r = 0.35; 95% CI: 0.07 to 0.58; P = .012)., Conclusions: The higher the initial protrusion was, the higher were the hard tissue gain and the final protrusion of the implant above the apical level of the hard tissue.
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- 2024
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43. Implants Placed with a Ring Technique Using Inlay and Onlay Block Xenografts in the Mandible of Rabbits.
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Kaneko N, Xavier SP, Morinaga K, Botticelli D, Silva ER, Nakajima Y, and Baba S
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Background: Xenogenous bone has been proposed as an alternative to overcome the disadvantages of autogenous grafting. The aim of the present study was to study bone dynamics at inlay and onlay xenografts used for bone augmentation applying a ring technique., Methods: The bone at the lateral surface of the mandibular angle of 12 adult male New Zealand White rabbits was exposed bilaterally. The cortical layer received multiple perforations on one side of the mandible, and a xenograft block of collagenated cancellous equine bone, 7 mm in diameter and 3 mm in width, was fixed on the prepared surface using an implant (onlay group). On the opposite side, a defect 7 mm in diameter and 3 mm in depth was prepared, and the xenograft block was adapted to the defect and fixed with an implant (inlay group)., Results: After ten weeks of healing, in the onlay grafts, new bone was mainly formed on the trabeculae surface, reaching in some specimens the most coronal regions of the block. In the inlay grafts, new bone was found arranged on the trabecular surfaces but also occupying the spaces among the trabeculae. The entrance of the defect was often found close to the top of the block by newly formed bone. A higher percentage of new bone was found in the inlay (19.0 ± 9.3%) compared to the onlay (10.4 ± 7.4%) groups ( p = 0.031). The mean gain in osseointegration at the implant in relation to the base of the original 3 mm deep defect was 0.95 ± 1.05% in the onlay group and 0.78 ± 0.71% in the inlay group ( p = 0.603)., Conclusion: The inlay grafts exhibited a higher new bone percentage than the onlay block grafts possibly due to the defect conformation that presented more sources for bone growth. The trabecular conformation and the composition of the grafts made possible the expression of the osteoconductive properties of the material used. This resulted, in several specimens, in the growth of bone on the graft trabeculae toward the most superior regions in both groups and in the closure of the coronal entrance of the defects in the inlay group. The clinical relevance of this experiment is that the ring technique applied as an inlay method could be suitable for bone augmentation.
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- 2023
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44. Histological Comparison of Collagenated Cancellous Equine Bone Blocks Used as Inlay or Onlay for Lateral Bone Augmentation in Rabbits.
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Sakaguchi R, Xavier SP, Morinaga K, Botticelli D, Silva ER, Nakajima Y, and Baba S
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Background: The conformation of the recipient site for an inlay graft presents an increased contact with the parent bone compared to an onlay graft. This might favor bone growth within the inlay compared to onlay grafts. Hence, the objective of this study was to compare the bone incorporation and remodeling processes of xenogeneic en bloc grafts placed using two bone grafting techniques, i.e., onlay vs. inlay., Methods: In this prospective, randomized, split-mouth study (test and control sides in the same animal), two bone grafting techniques were comparatively evaluated. The lateral aspect of the rabbit mandible was used as the recipient site, bilaterally. On one side of the mandible, the cortical bone was perforated with drills to allow a better bone formation from the bone wound and the marrow spaces. A xenogeneic bone block was fixed in the center of the prepared region, representing the onlay site. On the other side of the mandible, a 7 mm wide and 3 mm deep circumferential defect was prepared using trephines and drills. A xenogeneic bone block was fixed in the center of the defect, representing the inlay site. Two healing periods were applied in the study: 2 and 10 weeks, each represented by 10 rabbits ( n = 10 for each period)., Results: After 2 weeks of healing, the mean percentage of new bone was 10.4% and 23.3% at the onlay and inlay grafts, respectively ( p = 0.022). After 10 weeks of healing, new bone increased to 13.2% at the onlay sites and 25.4% at the inlay sites ( p = 0.080). In the 10-week period, the inlay grafts presented a homogeneous growth of new bone in all regions, while in the onlay grafts, low percentages of new bone were observed in the external regions., Conclusion: The percentage of new bone increased faster and was higher in the inlay grafts than in the onlay grafts. This outcome might be related to the self-contained conformation of the recipient site in the inlay group, which offered more sources for new bone formation compared to the one-wall conformation of the recipient sites in the onlay group. The osteoconductive properties of the biomaterial allowed the newly formed bone to reach the most peripheral regions in both groups. The osteoconductive properties of the biomaterial, together with the protection offered by the collagen membrane, allowed marginal closure of the defects by newly formed bone in the inlay group.
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- 2023
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45. Correction to: Influence of the use of autogenous bone particles to close the access window after maxillary sinus floor augmentation: a micro-computed tomography and positron emission tomography study in rabbits.
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Feletto L, Botticelli D, Apaza Alccayhuaman KA, Peñarrocha-Diago M, Ezzeddin-Ayoub M, Zaragozi-Alonso R, and Viña-Almunia J
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- 2023
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46. Mucosal adhesion phenomenon after maxillary sinus floor elevation: A preclinical study.
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Nakajima Y, Apaza Alccayhuaman KA, Botticelli D, Lang NP, De Rossi EF, and Xavier SP
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- Animals, Rabbits, Mucous Membrane, Connective Tissue, Maxillary Sinus surgery, Maxillary Sinus pathology, Sinus Floor Augmentation
- Abstract
Aim: To describe the histological events that occur after maxillary sinus floor elevation when the elevated and undetached sinus mucosa are in close proximity or in contact with each other., Materials and Methods: From 76 rabbits, 152 elevated maxillary sinuses were analyzed histologically. Sites without adhesions were classified as "No proximity," whereas the adhesion stages were divided into "Proximity," "Fusion," and "Synechia stages." The width of the pseudostratified columnar epithelium and the distance between the two layers of the elevated and undetached sinus mucosae were measured at various standardized positions., Results: Thirty-one sites presenting with adhesions were found. Twelve sites were in the proximity stage," presenting cilia of the two epithelial layers that were shortened and interlinked within the mucous context. Hyperactivity of the goblet cells was also observed. In the other cases, the hyperplastic epithelium showed attempts to reach the contralateral mucosa. The 15 "fusion stage" sites presented regions with epithelial cells of the two mucosal layers that penetrated each other. Four sites presented "synechiae stages," represented by bridges of connective tissue connecting the two lamina propria., Conclusions: Close proximity or tight contact between the elevated and undetached mucosa adhering to the bone walls might occur after maxillary sinus floor elevation. This induced hyperplasia of the epithelial cells and adhesion of the two layers until synechiae formation., (© 2023 The Authors. Clinical Oral Implants Research published by John Wiley & Sons Ltd.)
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- 2023
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47. ESEM-EDX Mineralization and Morphological Analysis of Human Retrieved Maxillary Sinus Bone Graft Biopsies before Loading.
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Imai H, Prati C, Zamparini F, Iezzi G, Botticelli D, Gandolfi MG, and Baba S
- Abstract
This study aimed to analyze the morphology of bone graft granules, the presence of granule demineralization, and bone morphology in retrieved human maxillary sinus bone graft biopsies. Healthy patients underwent sinus bone augmentation using lateral access. Two different dimensions of the antrostomy were performed, a 4 mm or 8 mm height. After 6 months, all sites received one implant using a flap technique, crestal positioning, and submerged healing. Implant biopsies were retrieved after 3 months and were histologically processed. The ESEM analysis was performed on the entire portion of the peri-implant bone (up to 750 µm from the implant thread). Three different regions of interest (ROIs) were selected: the coronal, middle, and apical portions of the implant. In these areas, EDX was performed, and calcium (Ca), phosphate (P), nitrogen (N), and their atomic ratios (Ca/P, Ca/N, and P/N) were calculated. Different bone tissue electron-dense areas were detected through grayscale intensity quantification of ESEM images with different organic (N) or inorganic (Ca,P) compositions. A total of 16 biopsies from 16 healthy patients were analyzed. Bone graft granules were mostly detected in the apical ROI. New bone tissue bridges were detected in the apical and middle ROI. These structures, with lower Ca/N and P/N ratios, were connected and enveloped the bone graft granules. Cortical ROI revealed the most mineralized bone tissue. Conclusions: After 9 months, bone graft resorption was only partially completed and new bone tissue appeared less mineralized in the middle and apical ROI than in the coronal ROI., Competing Interests: The authors declare no conflict of interest.
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- 2023
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48. Influence of the use of autogenous bone particles to close the access window after maxillary sinus floor augmentation: a micro-computed tomography and positron emission tomography study in rabbits.
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Feletto L, Botticelli D, Apaza Alccayhuaman KA, Peñarrocha-Diago M, Ezzeddin-Ayoub M, Zaragozi-Alonso R, and Viña-Almunia J
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- Swine, Rabbits, Humans, Male, Animals, X-Ray Microtomography, Wound Healing, Collagen, Bone Transplantation, Positron-Emission Tomography, Maxillary Sinus diagnostic imaging, Maxillary Sinus surgery, Minerals, Dental Implantation, Endosseous, Sinus Floor Augmentation methods, Bone Substitutes
- Abstract
Aim: The purpose of this study was to evaluate using microCT and positron emission tomography (PET) analysis, the influence on bone healing of the placement of particulate autogenous bone in the antrostomy, and in the subjacent region after maxillary sinus elevation with xenograft., Material and Methods: The sinus mucosa was elevated in sixteen male New Zealand rabbits and they were both grafted with a collagenated cortico-cancellous porcine bone. The antrostomy and the near subjacent region were filled with either the same xenograft (control site) or with particulate autogenous bone (test site) harvested from the tibia. The antrostomies were covered with collagen membranes. MicroCT (measured in Hounsfield Units) and microPET (kBq/cm
3 ) using sodium fluoride infiltration (18 F-NaF) were performed at the time of euthanasia that was performed after 1 and 8 weeks of healing, using 8 animals in each group. The Wilcoxon test was used for analysis., Results: At the microCT analysis, after 1 and 8 weeks of healing, no statistically significant differences were found between groups. Bone increased and xenograft decreased significantly between the two periods of healing. At the microPET analysis, the percentage of bone increased significantly over time in both test and control groups and no significant differences were found between groups., Conclusion: The placement of autogenous bone in the antrostomy and the subjacent region after maxillary sinus elevation did not enhance bone formation compared with sites where only xenograft was used. Both microCT and microPET showed increase bone formation over time., (© 2022. The Author(s).)- Published
- 2023
- Full Text
- View/download PDF
49. Evaluation of Two Configurations of Hydroxyapatite and Beta-Tricalcium Phosphate in Sinus Grafts with Simultaneous Implant Installation: An Experimental Study in Rabbits.
- Author
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Jacob RGM, Ervolino da Silva AC, Chaushu L, Lang NP, Borges Duailibe de Deus C, Botticelli D, and Rangel Garcia Júnior I
- Abstract
Background: This study aimed to evaluate peri-implant bone formation in rabbits after sinus grafting mediated by hydroxyapatite and beta-tricalcium phosphate (HA + β-TCP) in granule or paste configurations, concomitant with immediate implant installation., Material & Methods: Thirty-four rabbit maxillary sinuses were grafted with HA + β-TCP, half of which were applied in a granule and half in a paste composition. Implant placement was performed simultaneously. At 7 and 40 days postoperatively, the animals were euthanized, and samples were prepared for tomographic, microtomographic, histological, histometric (hematoxylin and eosin staining, HE), and immunohistochemical (labeling of transcription factor Runx-2 [RUNX2], vascular endothelial growth factor [VEGF], osteocalcin [OCN], and tartrate-resistant acid phosphatase [TRAP]) analysis. Implant removal torque was also measured., Results: On tomography, maintenance of sinus membrane integrity was observed in both the groups. Higher values of morphometric parameters evaluated by micro-CT were found in the "paste group" after seven days. At 40 days, there were no significant differences between the groups in most of the microtomographic parameters evaluated. In histological sections stained with HE, a higher percentage of newly formed bone was observed in the "granule group" after 40 days. Similar positive immunolabeling was observed for both RUNX2 and OCN in both the experimental groups. TRAP immunolabeling was similar in both groups as well. VEGF labeling increased in the "granule group", indicating a higher osteoconductive potential in this biomaterial. Similar removal torque values were observed in both groups. Thus, the two HA + β-TCP configurations showed similar healing patterns of simultaneously installed implants adjacent to sinus floor elevation. However, significantly higher bone values were observed for the "granule configuration"., Conclusions: The HA + β-TCP granules and paste presentations showed favorable long-term healing results, with bone formation in similar quantities and quality adjacent to the implants.
- Published
- 2023
- Full Text
- View/download PDF
50. The Effect of Anticoagulants on Early Implant Failure: A Retrospective Cohort Study.
- Author
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Chaushu L, Perez N, Botticelli D, Xavier SP, Kolerman R, and Masri D
- Abstract
Background: Anticoagulants (AC) are among the most often prescribed drugs in the world. Data regarding ACs' effect on the osseointegration of dental implants is lacking., Purpose: The aim of the present retrospective cohort study was to evaluate the effect of anticoagulants (AC) on early implant failure (EIF). The null hypothesis was that the use of AC increases the incidence of EIF., Materials and Methods: The research included 687 patients who underwent 2971 dental implant placements in the department of oral and maxillofacial surgery in Rabin medical center, Beilinson hospital, by specialists in oral and maxillofacial surgery. The study group comprised 173 (25.2%) patients and 708 (23.8%) implants using AC. The rest of the cohort served as a control. A structured form was used to collect data at patient and implant level. EIF was defined as implant failure within a period of up to 12 months from loading. EIF was the primary outcome parameter. A logistic regression model was used to predict EIF., Results: Implants placed in individuals ≥ 80 (odds ratio (OR) = 0.34, p = 0.05), and ASA 2/3 vs. ASA 1 individuals (OR = 0.30, p = 0.02/OR = 0.33, p = 0.03, respectively) had decreased odds of EIF, and implants in those using anticoagulants (OR = 2.64, p = 0.01) had increased odds of EIF. At the patient level, the odds of EIF in ASA 3 (OR = 0.53, p = 0.02) and IHD (OR = 0.40, p = 0.02) individuals decreased. In AF/VF (OR = 2.95, p = 0.01) individuals, EIF odds increased., Conclusions: Within the limitations of the present study, the use of AC is significantly associated with an increased likelihood of EIF: the OR was 2.64. Future research is required to validate and examine the prospective impact of AC on the osseointegration phenomena., Competing Interests: The authors declare no conflict of interest.
- Published
- 2023
- Full Text
- View/download PDF
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