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1. Simultaneous, free-breathing, non-contrast 3D whole-heart coronary magnetic resonance angiography and vulnerable plaque imaging in patients with suspected acute coronary syndrome

Author

Hajhosseiny, R, primary, Hartley, A, additional, Cole, G, additional, Munoz, C, additional, Sethi, A H, additional, Al-Lamee, R, additional, Khawaja, S, additional, Zaman, S, additional, Howard, J, additional, Ariff, B, additional, Neji, R, additional, Kunze, K, additional, Prieto, C, additional, Khamis, R, additional, and Botnar, R, additional

Published
2023
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2. Molecular MRI of MPO activity detects ruptured human atherosclerotic plaques and predicts atherothrombosis in an animal model

Author

Nadel, J., primary, Wang, X., additional, Saha, P., additional, Bongers, A., additional, Tumanov, S., additional, Giannotti, N., additional, Chen, W., additional, Jabbour, A., additional, Chowdhury, M., additional, Da Cruz, G. Lima, additional, Jimeno, C. Velasco, additional, Vasquez, C. Prieto, additional, Botnar, R., additional, Stocker †, R., additional, and Phinikaridou †, A., additional

Published
2023
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6. Combined PET/MRI: from Status Quo to Status Go. Summary Report of the Fifth International Workshop on PET/MR Imaging; February 15–19, 2016; Tübingen, Germany

Author

Bailey, D. L., Pichler, B. J., Gückel, B., Barthel, H., Beer, A. J., Botnar, R., Gillies, R., Goh, V., Gotthardt, M., Hicks, R. J., Lanzenberger, R., la Fougere, C., Lentschig, M., Nekolla, S. G., Niederdraenk, T., Nikolaou, K., Nuyts, J., Olego, D., Riklund, K. Åhlström, Signore, A., Schäfers, M., Sossi, V., Suminski, M., Veit-Haibach, P., Umutlu, L., Wissmeyer, M., and Beyer, T.

Published
2016
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17. Society for Cardiovascular Magnetic Resonance (SCMR) expert consensus for CMR imaging endpoints in clinical research: part I - analytical validation and clinical qualification

Author

Puntmann, VO, Valbuena, S, Hinojar, R, Petersen, SE, Greenwood, JP, Kramer, CM, Kwong, RY, McCann, GP, Berry, C, Nagel, E, Bluemke, D, Bremerich, J, Botnar, R, Bucciarelli-Ducci, C, Choudhury, RP, Dweck, M, Eitel, I, Ferrari, V, Friedrich, M, Hundley, G, Lombardi, M, Lopez Fernandez, T, Marwick, T, Narula, J, Neubauer, S, Patel, A, Pennell, D, Plein, S, Prasad, S, Rademakers, F, Raman, S, Sakuma, H, Sanz, J, Schulz-Menger, J, Simonetti, O, Swift, A, Taylor, AJ, Teixeira, T, Thiele, H, Ugander, M, Westenberg, JJ, and Young, AA

Subjects
Population ageing, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Consensus, Cardiac magnetic resonance, SCMR, Context (language use), Disease, 030204 cardiovascular system & hematology, 1102 Cardiovascular Medicine And Haematology, 030218 nuclear medicine & medical imaging, Imaging, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Medical physics, Position paper, Evidence-Based Medicine, Radiological and Ultrasound Technology, business.industry, Reproducibility of Results, Biomarker, Prognosis, Magnetic Resonance Imaging, Clinical trial, Nuclear Medicine & Medical Imaging, Clinical research, Software deployment, lcsh:RC666-701, Cardiovascular Diseases, Cardiology and Cardiovascular Medicine, business, Strengths and weaknesses
Abstract

Cardiovascular disease remains a leading cause of morbidity and mortality globally. Changing natural history of the disease due to improved care of acute conditions and ageing population necessitates new strategies to tackle conditions which have more chronic and indolent course. These include an increased deployment of safe screening methods, life-long surveillance, and monitoring of both disease activity and tailored-treatment, by way of increasingly personalized medical care. Cardiovascular magnetic resonance (CMR) is a non-invasive, ionising radiation-free method, which can support a significant number of clinically relevant measurements and offers new opportunities to advance the state of art of diagnosis, prognosis and treatment. The objective of the SCMR Clinical Trial Taskforce was to summarizes the evidence to emphasize where currently CMR-guided clinical care can indeed translate into meaningful use and efficient deployment of resources results in meaningful and efficient use. The objective of the present initiative was to provide an appraisal of evidence on analytical validation, including the accuracy and precision, and clinical qualification of parameters in disease context, clarifying the strengths and weaknesses of the state of art, as well as the gaps in the current evidence This paper is complementary to the existing position papers on standardized acquisition and post-processing ensuring robustness and transferability for widespread use. Themed imaging-endpoint guidance on trial design to support drug-discovery or change in clinical practice (part II), will be presented in a follow-up paper in due course. As CMR continues to undergo rapid development, regular updates of the present recommendations are foreseen. ispartof: J Cardiovasc Magn Reson vol:20 issue:1 pages:67- ispartof: location:England status: Published online

Published
2018

18. Self-gated respiratory-resolved 5D Flow MRI using the 3D spiral phyllotaxis trajectory

Author

Sigovan, M., Cruz, G, Schneider, T., Perez-Juste Abascal, J.F., Mory, C., G., Krishnamoorty, Botnar, R., Douek, P., Prieto, C., Boussel, Loic, Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), iMagX/MIRO, Université Catholique de Louvain = Catholic University of Louvain (UCL), Department of Radiology, Cardiological Hospital, and Hospices Civils de Lyon

Subjects
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

19. Current and Emerging Preclinical Approaches for Imaging-Based Characterization of Atherosclerosis

Author

Vigne, J., Thackeray, J., Essers, J., Makowski, M., Varasteh, Z., Curaj, A., Karlas, A., Canet-Soulas, Emmanuelle, Mulder, W., Kiessling, F., Schafers, M., Botnar, R., Wildgruber, M., Hyafil, F., Cardiovasc Study Grp European, Soc, CarMeN, laboratoire, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Humbolt University, Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Institut National de la Recherche Agronomique (INRA)

Subjects
optical coherence, [SDV]Life Sciences [q-bio], Imaging-based characterization, iron-oxide, Preclinical approaches, matrix metalloproteinases, mri contrast, ultrasmall superparamagnetic particles, tomography, Atherosclerosis, in-vivo, positron-emission-tomography, agents, ray computed-tomography, [SDV] Life Sciences [q-bio], Nuclear Medicine & Medical Imaging, proof-of-concept, cell-adhesion molecule-1, Radiology
Abstract

Atherosclerotic plaques can remain quiescent for years, but become life threatening upon rupture or disruption, initiating clot formation in the vessel lumen and causing acute myocardial infarction and ischemic stroke. Whether and how a plaque ruptures is determined by its macroscopic structure and microscopic composition. Rupture-prone plaques usually consist of a thin fibrous cap with few smooth muscle cells, a large lipid core, a dense infiltrate of inflammatory cells, and neovessels. Such lesions, termed high-risk plaques, can remain asymptomatic until the thrombotic event. Various imaging technologies currently allow visualization of morphological and biological characteristics of high-risk atherosclerotic plaques. Conventional protocols are often complex and lack specificity for high-risk plaque. Conversely, new imaging approaches are emerging which may overcome these limitations. Validation of these novel imaging techniques in preclinical models of atherosclerosis is essential for effective translational to clinical practice. Imaging the vessel wall, as well as its biological milieu in small animal models, is challenging because the vessel wall is a small structure that undergoes continuous movements imposed by the cardiac cycle as it is adjacent to circulating blood. The focus of this paper is to provide a state-of-the-art review on techniques currently available for preclinical imaging of atherosclerosis in small animal models and to discuss the advantages and limitations of each approach.

Published
2018

20. P5249Comprehensive invasive and non-invasive assessment of coronary artery lesions with and without hemodynamic significance

Author

Engel, L C, primary, Landmesser, U, additional, Abdelwahed, Y, additional, Gigengack, K, additional, Manes, C, additional, Wurster, T.-H, additional, Skurk, C, additional, Leistner, D.-M, additional, Lauten, A, additional, Schuster, A, additional, Noutsias, M, additional, Hamm, B, additional, Botnar, R M, additional, Makowski, M, additional, and Bigalke, B, additional

Published
2019
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25. Respiratory-resolved self-gated 3D radial 4D flow MRI: Initial results

Author

Sigovan, M., Schneider, T., Cruz, G, Mory, C., Botnar, R., Boussel, L, Douek, P., Prieto, C., Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), iMagX/MIRO, Université Catholique de Louvain = Catholic University of Louvain (UCL), Department of Radiology, Cardiological Hospital, and Hospices Civils de Lyon

Subjects
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

26. Peptide-based Contrast Agents: Novel probes for high-risk atherosclerotic plaques and metastasis imaging

Author

Lacerda, S., Phinikaridou, A., Lavin, B., Andia, M., Botnar R., M., TÓth, E., Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Systèmes de Référence Temps Espace (SYRTE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Frapart, Isabelle

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

29. P6208Endothelial damage and its relation to coronary artery stenosis. A correlation between molecular cardiovascular magnetic resonance imaging, and quantitative coronary angiography

Author

Engel, L C, primary, Landmesser, U L, additional, Abdelwahed, Y A, additional, Gigengack, K G, additional, Manes, C M, additional, Wurster, T H W, additional, Skurk, C S, additional, Leistner, D L, additional, Lauten, A L, additional, Schuster, A S, additional, Noutsias, M N, additional, Hamm, B H, additional, Botnar, R B, additional, Makowski, M M, additional, and Bigalke, B B, additional

Published
2018
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33. FPGA-based RF interference reduction techniques for simultaneous PET-MRI

Author

Gebhardt, P, Wehner, J, Weissler, B, Botnar, R, Marsden, P K, and Schulz, V

Subjects
Paper, RF interference reduction, Phantoms, Imaging, Radio Waves, digital, SiPM, Signal-To-Noise Ratio, Magnetic Resonance Imaging, Electromagnetic Fields, Positron-Emission Tomography, Image Processing, Computer-Assisted, Humans, MR compatibility, Artifacts, FPGA, PET–MRI
Abstract

Physics in medicine and biology 61(9), 3500-3526 (2016). doi:10.1088/0031-9155/61/9/3500, Published by IOP Publ., Bristol

Published
2016

34. Combined PET/MRI: from Status Quo to Status Go. Summary Report of the Fifth International Workshop on PET/MR Imaging; February 15-19, 2016; Tubingen, Germany

Author

Bailey, D.L., Pichler, B.J., Guckel, B., Barthel, H., Beer, A.J., Botnar, R., Gillies, R., Goh, V., Gotthardt, M., Hicks, R.J., Lanzenberger, R., Fougere, C. la, Lentschig, M., Nekolla, S.G., Niederdraenk, T., Nikolaou, K., Nuyts, J., Olego, D., Riklund, K.A., Signore, A., Schafers, M., Sossi, V., Suminski, M., Veit-Haibach, P., Umutlu, L., Wissmeyer, M., Beyer, T., Bailey, D.L., Pichler, B.J., Guckel, B., Barthel, H., Beer, A.J., Botnar, R., Gillies, R., Goh, V., Gotthardt, M., Hicks, R.J., Lanzenberger, R., Fougere, C. la, Lentschig, M., Nekolla, S.G., Niederdraenk, T., Nikolaou, K., Nuyts, J., Olego, D., Riklund, K.A., Signore, A., Schafers, M., Sossi, V., Suminski, M., Veit-Haibach, P., Umutlu, L., Wissmeyer, M., and Beyer, T.

Abstract

Contains fulltext : 172154.pdf (publisher's version ) (Open Access), This article provides a collaborative perspective of the discussions and conclusions from the fifth international workshop of combined positron emission tomorgraphy (PET)/magnetic resonance imaging (MRI) that was held in Tubingen, Germany, from February 15 to 19, 2016. Specifically, we summarise the second part of the workshop made up of invited presentations from active researchers in the field of PET/MRI and associated fields augmented by round table discussions and dialogue boards with specific topics. This year, this included practical advice as to possible approaches to moving PET/MRI into clinical routine, the use of PET/MRI in brain receptor imaging, in assessing cardiovascular diseases, cancer, infection, and inflammatory diseases. To address perceived challenges still remaining to innovatively integrate PET and MRI system technologies, a dedicated round table session brought together key representatives from industry and academia who were engaged with either the conceptualisation or early adoption of hybrid PET/MRI systems. Discussions during the workshop highlighted that emerging unique applications of PET/MRI such as the ability to provide multi-parametric quantitative and visual information which will enable not only overall disease detection but also disease characterisation would eventually be regarded as compelling arguments for the adoption of PET/MR. However, as indicated by previous workshops, evidence in favour of this observation is only growing slowly, mainly due to the ongoing inability to pool data cohorts from independent trials as well as different systems and sites. The participants emphasised that moving from status quo to status go entails the need to adopt standardised imaging procedures and the readiness to act together prospectively across multiple PET/MRI sites and vendors.

Published
2016

35. Combined PET/MRI: from Status Quo to Status Go. Summary Report of the Fifth International Workshop on PET/MR Imaging; February 15-19, 2016; Tubingen, Germany

Author

Bailey, DL, Pichler, BJ, Gueckel, B, Barthel, H, Beer, AJ, Botnar, R, Gillies, R, Goh, V, Gotthardt, M, Hicks, RJ, Lanzenberger, R, la Fougere, C, Lentschig, M, Nekolla, SG, Niederdraenk, T, Nikolaou, K, Nuyts, J, Olego, D, Ahlstrom Riklund, K, Signore, A, Schaefers, M, Sossi, V, Suminski, M, Veit-Haibach, P, Umutlu, L, Wissmeyer, M, Beyer, T, Bailey, DL, Pichler, BJ, Gueckel, B, Barthel, H, Beer, AJ, Botnar, R, Gillies, R, Goh, V, Gotthardt, M, Hicks, RJ, Lanzenberger, R, la Fougere, C, Lentschig, M, Nekolla, SG, Niederdraenk, T, Nikolaou, K, Nuyts, J, Olego, D, Ahlstrom Riklund, K, Signore, A, Schaefers, M, Sossi, V, Suminski, M, Veit-Haibach, P, Umutlu, L, Wissmeyer, M, and Beyer, T

Abstract

This article provides a collaborative perspective of the discussions and conclusions from the fifth international workshop of combined positron emission tomorgraphy (PET)/magnetic resonance imaging (MRI) that was held in Tübingen, Germany, from February 15 to 19, 2016. Specifically, we summarise the second part of the workshop made up of invited presentations from active researchers in the field of PET/MRI and associated fields augmented by round table discussions and dialogue boards with specific topics. This year, this included practical advice as to possible approaches to moving PET/MRI into clinical routine, the use of PET/MRI in brain receptor imaging, in assessing cardiovascular diseases, cancer, infection, and inflammatory diseases. To address perceived challenges still remaining to innovatively integrate PET and MRI system technologies, a dedicated round table session brought together key representatives from industry and academia who were engaged with either the conceptualisation or early adoption of hybrid PET/MRI systems. Discussions during the workshop highlighted that emerging unique applications of PET/MRI such as the ability to provide multi-parametric quantitative and visual information which will enable not only overall disease detection but also disease characterisation would eventually be regarded as compelling arguments for the adoption of PET/MR. However, as indicated by previous workshops, evidence in favour of this observation is only growing slowly, mainly due to the ongoing inability to pool data cohorts from independent trials as well as different systems and sites. The participants emphasised that moving from status quo to status go entails the need to adopt standardised imaging procedures and the readiness to act together prospectively across multiple PET/MRI sites and vendors.

Published
2016

37. Reference region-based pharmacokinetic modeling in quantitative dynamic contract-enhanced MRI allows robust treatment monitoring in a rat liver tumor model despite cardiovascular changes

Author

Steingoetter, A., Jonas Svensson, Kosanke, Y., Botnar, R. M., Schwaiger, M., Rummeny, E., Braren, R., University of Zurich, and Steingoetter, Andreas

Subjects
10219 Clinic for Gastroenterology and Hepatology, Radiology Nuclear Medicine and imaging, 2741 Radiology, Nuclear Medicine and Imaging, 610 Medicine & health
Published
2011

38. Molecular Imaging in Cardiovascular Diseases

Author

Botnar, R., additional, Ebersberger, H., additional, Noerenberg, D., additional, Jansen, C., additional, Wiethoff, A., additional, Schuster, A., additional, Kasner, M., additional, Walter, T., additional, Knobloch, G., additional, Hoppe, P., additional, Diederichs, G., additional, Hamm, B., additional, and Makowski, M., additional

Published
2015
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41. High Spatial Resolution and High Contrast Visualization of Brain Arteries and Veins: Impact of Blood Pool Contrast Agent and Water-Selective Excitation Imaging at 3T

Author

Spuentrup, E., Jacobs, J. E., Kleimann, J. F., Wiethoff, A. J., Poggenborg, J., Brinker, G., Loehr, M., Hartmann, W. Moeller, Botnar, R. M., Emestus, R. I., Lackner, K. J., Spuentrup, E., Jacobs, J. E., Kleimann, J. F., Wiethoff, A. J., Poggenborg, J., Brinker, G., Loehr, M., Hartmann, W. Moeller, Botnar, R. M., Emestus, R. I., and Lackner, K. J.

Abstract

Purpose To investigate a blood pool contrast agent and water-selective excitation imaging at 3T for high spatial and high contrast imaging of brain vessels including the veins Methods and Results 48 clinical patients (47 +/- 18years old) were included Based on clinical findings twenty-four patients received a single dose of standard extracellular Gadoterate-meglumine (Dotareme (R)) and 24 received the blood pool contrast agent Gadofosveset (Vasovist (R)) After finishing routine MR protocols, all patients were investigated with two high spatial resolution (0 15 mm(3) voxel size) gradient echo sequences in random order in the equilibrium phase (steadystate) as approved by the review board A standard RF-spoiled gradient-echo sequence (HR-SS TR/TE 5 1/2 3 msec, FA 30 degrees) and a fat-suppressed gradient-echo sequence with water-selective excitation (HR-FS 1331 binominal-pulse, TRITE 8 8/3 8 msec FA 30 degrees) The images were subjectively assessed (image quality with vessel contrast artifacts depiction of lesions) by two investigators and contrast-to-noise ratios (CNR) were compared using the Student's t-test The image quality and CNR in the HR-FS were significantly superior compared to the HR-SS for both contrast agents (p < 0 05) The CNR was also improved when using the blood pool agent but only to a minor extent while the subjective image quality was similar for both contrast agents Conclusion The utilized sequence with water-selective excitation improved image quality and CNR properties in high spatial resolution imaging of brain arteries and veins The used blood pool contrast agent improved the CNR only to a minor extent over the extracellular contrast agent

Published
2010

46. High Spatial Resolution and High Contrast Visualization of Brain Arteries and Veins: Impact of Blood Pool Contrast Agent and Water-Selective Excitation Imaging at 3T

Author

Spuentrup, E., primary, Jacobs, J., additional, Kleimann, J., additional, Wiethoff, A., additional, Poggenborg, J., additional, Brinker, G., additional, Loehr, M., additional, Möller-Hartmann, W., additional, Botnar, R., additional, Ernestus, R.-I., additional, and Lackner, K.-J., additional

Published
2010
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