280 results on '"Botha, H"'
Search Results
2. A rapid fishery assessment to collect biological information and life-history parameters for rednose labeo Labeo rosae and Mozambique tilapia Oreochromis mossambicus in Loskop Dam, Olifants River, South Africa.
- Author
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Hlungwani, HA, Marr, SM, Weyl, OLF, Hoffman, AC, Botha, H, and Sara, JR
- Subjects
MOZAMBIQUE tilapia ,FRESHWATER fishes ,NATIVE species ,NATIVE fishes ,FISH mortality ,TILAPIA - Abstract
A 2-week rapid fishery assessment using various sampling gears was conducted to collect life-history data on rednose labeo Labeo rosae and Mozambique tilapia Oreochromis mossambicus in Loskop Dam on the Olifants River, Mpumalanga Province, South Africa. These native species were the two most-abundant fish species caught in the impoundment during the study. Both species displayed a bimodal population size distribution comprised of recent recruits and large-sized individuals. Isometric growth (b value ∼3), an asymptotic length (L
∞ ) of 447 mm, and length at 50% sexual maturity (Lm50 ) of 198 mm were estimated for L. rosae. Isometric growth, L∞ of 451 mm, and Lm50 of 124 mm were estimated for O. mossambicus. This rapid assessment at Loskop Dam produced sets of life-history parameters comparable to those previously reported for these two species in Flag Boshielo Dam, ∼80 km downstream. [ABSTRACT FROM AUTHOR]- Published
- 2024
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3. A computational model of neurodegeneration in Alzheimer’s disease
- Author
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Jones, D., Lowe, V., Graff-Radford, J., Botha, H., Barnard, L., Wiepert, D., Murphy, M. C., Murray, M., Senjem, M., Gunter, J., Wiste, H., Boeve, B., Knopman, D., Petersen, R., and Jack, C.
- Published
- 2022
- Full Text
- View/download PDF
4. 105 PET-CT findings in HIV-positive and negative patients with locally advanced cervical cancer in a south african cohort
- Author
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Simonds, H, Botha, H, Ellmann, A, Warwick, J, Doruyter, A, Van der Merwe, H, and Jacobson, J
- Published
- 2019
- Full Text
- View/download PDF
5. P.003 CJD in the modern era: The value of clinical features and diagnostic tests
- Author
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Shir, D, primary, Lazar, EB, additional, Graff-Radford, J, additional, Aksamit, AJ, additional, Cutsforth-Gregory, JK, additional, Jones, DT, additional, Botha, H, additional, Ramanan, VK, additional, Prusinski, CC, additional, Porter, AL, additional, and Day, GS, additional
- Published
- 2022
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6. Transcriptional regulation of glucose transporters in human oral squamous cell carcinoma cells
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Paolini, R, Moore, C, Matthyssen, T, Cirillo, N, McCullough, M, Farah, CS, Botha, H, Yap, T, Celentano, A, Paolini, R, Moore, C, Matthyssen, T, Cirillo, N, McCullough, M, Farah, CS, Botha, H, Yap, T, and Celentano, A
- Abstract
The increased glucose uptake observed in cancer cells is mediated by glucose transporters (GLUTs), a class of transmembrane proteins that facilitate the transport of glucose and other substrates across the plasma membrane. Despite the important role of glucose in the pathophysiology of oral squamous cell carcinoma (OSCC), there is very limited data regarding the expression of GLUTs in normal or malignant cells from the oral mucosa. We analysed the messenger RNA (mRNA) expression of all 14 GLUTs in two OSCC (H357/H400) and one non-malignant oral keratinocyte (OKF6) cell line using a quantitative polymerase chain reaction. GLUT expression was evaluated at baseline and after treatment with two specific GLUT inhibitors, namely, BAY876 (GLUT1) and WZB117 (GLUT1, GLUT3 and GLUT4). Here, we show that GLUT1, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT12 and GLUT13 transcripts were measurably expressed in all cell lines while GLUT2, GLUT7, GLUT9, GLUT11 and GLUT14 were not expressed. GLUT10 was only found in H357. In the presence of BAY876 and WZB117, OSCC cells exhibited significant alterations in the transcriptional profile of GLUTs. In particular, we observed distinct proliferation-dependent changes of mRNAs to GLUT1, GLUT3, GLUT4, GLUT5 and GLUT6 in response to selective GLUT inhibitors. In summary, we documented for the first time the expression of GLUT5, GLUT6 and GLUT12 in normal and malignant oral keratinocytes. Whilst regulation of GLUT transcripts was cell line and inhibitor specific, GLUT3 was consistently upregulated in actively proliferating OSCC cell lines, but not in OKF6, regardless of the inhibitor used, suggesting that modulation of this transporter may act as one of the primary compensation mechanisms for OSCC cells upon inhibition of glucose uptake.
- Published
- 2022
7. The examination, analysis and conservation of a bronze Egyptian Horus statuette
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Smith, A., Botha, H., de Beer, F.C., and Ferg, E.
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- 2011
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8. Archaeology benefits from neutron tomography investigations in South Africa
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de Beer, F.C., Botha, H., Ferg, E., Grundlingh, R., and Smith, A.
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- 2009
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9. Changes in Ventricular and Cortical Volumes following Shunt Placement in Patients with Idiopathic Normal Pressure Hydrocephalus
- Author
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Cogswell, P.M., primary, Murphy, M.C., additional, Senjem, M.L., additional, Botha, H., additional, Gunter, J.L., additional, Elder, B.D., additional, Graff-Radford, J., additional, Jones, D.T., additional, Cutsforth-Gregory, J.K., additional, Schwarz, C.G., additional, Meyer, F.B., additional, Huston, J., additional, and Jack, C.R., additional
- Published
- 2021
- Full Text
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10. Gearing up for the future: Exploring facilitators and barriers to inform clinical trial design in frontotemporal lobar degeneration
- Author
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Banga, YB, Banga, YB, Lai, Y, Kim, P, Boeve, BF, Boxer, AL, Rosen, HJ, Forsberg, LK, Heuer, HW, Brushaber, D, Appleby, B, Biernacka, JM, Bordelon, YM, Botha, H, Bozoki, AC, Brannelly, P, Dickerson, BC, Dickinson, S, Dickson, DW, Domoto-Reilly, K, Faber, K, Fagan, AM, Fields, JA, Fishman, A, Foroud, TM, Galasko, DR, Gavrilova, RH, Gendron, TF, Geschwind, DH, Ghoshal, N, Goldman, J, Graff-Radford, J, Graff-Radford, NR, Grant, I, Grossman, M, Hsiung, GYR, Huang, EJ, Huey, ED, Irwin, DJ, Jones, DT, Kantarci, K, Karydas, AM, Kaufer, D, Knopman, DS, Kramer, JH, Kremers, WK, Kornak, J, Kukull, WA, Lagone, E, Leger, GC, Litvan, I, Ljubenkov, PA, Lucente, DE, Mackenzie, IR, Manoochehri, M, Masdeu, JC, McGinnis, S, Mendez, MF, Miller, BL, Miyagawa, T, Nelson, KM, Onyike, CU, Pantelyat, A, Pascual, B, Pearlman, R, Petrucelli, L, Pottier, CP, Rademakers, R, Ramos, EM, Rankin, KP, Rascovsky, K, Rexach, JE, Ritter, A, Roberson, ED, Rojas, JC, Sabbagh, MN, Salmon, DP, Savica, R, Seeley, WW, Staffaroni, AM, Syrjanen, JA, Tartaglia, MC, Tatton, N, Taylor, JC, Toga, AW, Weintraub, S, Wheaton, D, Wong, B, Wszolek, Z, Banga, YB, Banga, YB, Lai, Y, Kim, P, Boeve, BF, Boxer, AL, Rosen, HJ, Forsberg, LK, Heuer, HW, Brushaber, D, Appleby, B, Biernacka, JM, Bordelon, YM, Botha, H, Bozoki, AC, Brannelly, P, Dickerson, BC, Dickinson, S, Dickson, DW, Domoto-Reilly, K, Faber, K, Fagan, AM, Fields, JA, Fishman, A, Foroud, TM, Galasko, DR, Gavrilova, RH, Gendron, TF, Geschwind, DH, Ghoshal, N, Goldman, J, Graff-Radford, J, Graff-Radford, NR, Grant, I, Grossman, M, Hsiung, GYR, Huang, EJ, Huey, ED, Irwin, DJ, Jones, DT, Kantarci, K, Karydas, AM, Kaufer, D, Knopman, DS, Kramer, JH, Kremers, WK, Kornak, J, Kukull, WA, Lagone, E, Leger, GC, Litvan, I, Ljubenkov, PA, Lucente, DE, Mackenzie, IR, Manoochehri, M, Masdeu, JC, McGinnis, S, Mendez, MF, Miller, BL, Miyagawa, T, Nelson, KM, Onyike, CU, Pantelyat, A, Pascual, B, Pearlman, R, Petrucelli, L, Pottier, CP, Rademakers, R, Ramos, EM, Rankin, KP, Rascovsky, K, Rexach, JE, Ritter, A, Roberson, ED, Rojas, JC, Sabbagh, MN, Salmon, DP, Savica, R, Seeley, WW, Staffaroni, AM, Syrjanen, JA, Tartaglia, MC, Tatton, N, Taylor, JC, Toga, AW, Weintraub, S, Wheaton, D, Wong, B, and Wszolek, Z
- Abstract
BACKGROUND: Frontotemporal lobar degeneration (FTLD) refers to a group of neurodegenerative conditions, affecting the frontal and/or temporal lobes. Ongoing research has provided insight into developing clinical trials for FTLD and key clinical measures such as structural MRI. To inform clinical trial design and optimize participation, it is imperative to explore facilitators and barriers for potential candidates. OBJECTIVE: The objective of this study is to explore facilitators and barriers to participating in future clinical trials for FTLD. METHODS: Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) and Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS) are observational studies focused on characterizing FTLD syndromes in preparation for clinical trials. The 584 participants enrolled across 18 research sites in the United States and Canada completed a survey assessing interest in clinical trial participation. RESULTS: 29% of respondents self-reported as patients (63±10 years), 26% self-reported as caregivers answering on behalf of patients (65±10 years), and 45% self-reported as healthy but at risk for FTLD (48±14 years). Travel reimbursement was the most common factor reported to positively influence participation (≧66%), with the healthy but at risk group showing the strongest endorsement (83%). Cost and time involved in travel were possible barriers for about half of the patients (48%) and healthy but at risk respondents (53%). The respondents value receiving feedback on the study findings (≧80%) and being informed of their individual disease progression (≧75%). Particularly, keeping participation confidential was very important for the healthy but at risk group (62%). In regard to research assessments, most participants demonstrated a high interest in physical and neurological exams at a research center (≧87%) whereas only half were interested in doing more invasive procedures such as the lumbar puncture
- Published
- 2021
11. The Role of Glucose Transporters in Oral Squamous Cell Carcinoma
- Author
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Botha, H, Farah, CS, Koo, K, Cirillo, N, McCullough, M, Paolini, R, Celentano, A, Botha, H, Farah, CS, Koo, K, Cirillo, N, McCullough, M, Paolini, R, and Celentano, A
- Abstract
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy associated with a poor prognosis. The Warburg effect can be observed in OSCCs, with tumours requiring a robust glucose supply. Glucose transporters (GLUTs) and sodium-glucose co-transporters (SGLTs) are overexpressed in multiple malignancies, and are correlated with treatment resistance, clinical factors, and poor overall survival (OS). We conducted a systematic review to evaluate the differences in GLUT/SGLT expression between OSCC and normal oral keratinocytes (NOK), as well as their role in the pathophysiology and prognosis of OSCC. A total of 85 studies were included after screening 781 papers. GLUT-1 is regularly expressed in OSCC and was found to be overexpressed in comparison to NOK, with high expression correlated to tumour stage, treatment resistance, and poor prognosis. No clear association was found between GLUT-1 and tumour grade, metastasis, and fluorodeoxyglucose (FDG) uptake. GLUT-3 was less thoroughly studied but could be detected in most samples and is generally overexpressed compared to NOK. GLUT-3 negatively correlated with overall survival (OS), but there was insufficient data for correlations with other clinical factors. Expression of GLUT-2/GLUT-4/GLUT-8/GLUT-13/SGLT-1/SGLT-2 was only evaluated in a small number of studies with no significant differences detected. GLUTs 7 and 14 have never been evaluated in OSCC. In conclusion, the data demonstrates that GLUT-1 and GLUT-3 have a role in the pathophysiology of OSCC and represent valuable biomarkers to aid OSCC diagnosis and prognostication. Other GLUTs are comparatively understudied and should be further analysed because they may hold promise to improve patient care.
- Published
- 2021
12. Demographic and psychosocial factors associated with the decision to learn mutation status in familial frontotemporal dementia and the impact of disclosure on mood
- Author
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Bajorek, LP, Bajorek, LP, Kiekhofer, R, Hall, M, Taylor, J, Lucente, DE, Brushaber, D, Appleby, B, Coppolla, G, Bordelon, YM, Botha, H, Dickerson, BC, Dickson, DW, Domoto-Reilly, K, Fagan, AM, Fields, JA, Fong, JC, Foroud, TM, Forsberg, LK, Galasko, DR, Gavrilova, RH, Geschwind, DH, Ghoshal, N, Goldman, J, Graff-Radford, NR, Graff-Radford, J, Grant, I, Grossman, M, Heuer, HW, Hsiung, GYR, Huang, EJ, Huey, ED, Irwin, DJ, Jones, DT, Kantarci, K, Kornak, J, Kremers, WK, Lapid, MI, Leger, GC, Litvan, I, Ljubenkov, PA, Mackenzie, IR, Masdeu, JC, McMillan, C, Mendez, M, Miller, BL, Miyagawa, T, Onyike, CU, Pascual, B, Pedraza, O, Petrucelli, L, Rademakers, R, Ramos, EM, Rankin, KP, Rascovsky, K, Rexach, JE, Ritter, A, Roberson, ED, Savica, R, Rojas, JC, Seeley, WW, Tartaglia, MC, Toga, AW, Weintraub, S, Wong, B, Wszolek, Z, Vandevrede, L, Boeve, BF, Boxer, AL, Rosen, HJ, Staffaroni, AM, Bajorek, LP, Bajorek, LP, Kiekhofer, R, Hall, M, Taylor, J, Lucente, DE, Brushaber, D, Appleby, B, Coppolla, G, Bordelon, YM, Botha, H, Dickerson, BC, Dickson, DW, Domoto-Reilly, K, Fagan, AM, Fields, JA, Fong, JC, Foroud, TM, Forsberg, LK, Galasko, DR, Gavrilova, RH, Geschwind, DH, Ghoshal, N, Goldman, J, Graff-Radford, NR, Graff-Radford, J, Grant, I, Grossman, M, Heuer, HW, Hsiung, GYR, Huang, EJ, Huey, ED, Irwin, DJ, Jones, DT, Kantarci, K, Kornak, J, Kremers, WK, Lapid, MI, Leger, GC, Litvan, I, Ljubenkov, PA, Mackenzie, IR, Masdeu, JC, McMillan, C, Mendez, M, Miller, BL, Miyagawa, T, Onyike, CU, Pascual, B, Pedraza, O, Petrucelli, L, Rademakers, R, Ramos, EM, Rankin, KP, Rascovsky, K, Rexach, JE, Ritter, A, Roberson, ED, Savica, R, Rojas, JC, Seeley, WW, Tartaglia, MC, Toga, AW, Weintraub, S, Wong, B, Wszolek, Z, Vandevrede, L, Boeve, BF, Boxer, AL, Rosen, HJ, and Staffaroni, AM
- Abstract
BACKGROUND: Up to 30% of frontotemporal dementia (FTD) cases are due to known pathogenic mutations (f-FTD). Little is known about the factors that predict who will choose to learn their results. Upcoming clinical trials in f-FTD may require disclosure prior to enrollment, even before symptom onset, and thus characterizing this sample is important. Furthermore, understanding the mood impacts of genetic disclosure may guide genetic counseling practice. METHOD: F-FTD participants (n=568) from families with a known pathogenic mutation (MAPT, C9orf72, GRN) were enrolled through the ARTFL/LEFFTDS Longitudinal FTD Study (ALLFTD) and provided the opportunity for disclosure. Independent-sample t-tests compared demographic and psychosocial factors between participants who did and did not receive their results. In participants who were asymptomatic at baseline and follow up (n=199,177 with follow-up), linear mixed effects modeling was used to investigate pre- to post-disclosure changes in the 15-item Geriatric Depression Scale (GDS). RESULT: Of participants from families with a known pathogenic genetic mutation, 47% received genetic disclosure. Of the asymptomatic subset (n=386), 36% know their mutation status. Of these asymptomatic learners, 46% received disclosure through the study, and the remainder learned their genetic status prior to study enrollment. None of the analyzed demographic or psychosocial factors (i.e., sex, age, education, having children) differed between learners and non-learners (p's > 0.05). In the longitudinal analysis of asymptomatic participants, learners showed a pre- to post-increase of 0.31 GDS points/year (95%CI: -0.08, 0.69, p = 0.12), whereas non-learners showed a slight decline (-0.15 points/year, 95%CI: -0.36, 0.06, p = 0.16). This difference between slopes was statistically significant (0.46, 95%CI: 0.02, 0.89, p=0.04) but represents a small clinical effect. In asymptomatic learners, slopes did not differ based on mutation status (0.28, 95%
- Published
- 2021
13. Patterns of neurodegeneration in dementia reflect a global functional state space
- Author
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Jones, D., primary, Lowe, V., additional, Graff-Radford, J., additional, Botha, H., additional, Wiepert, D., additional, Murphy, M.C., additional, Murray, M., additional, Senjem, M., additional, Gunter, J., additional, Wiste, H., additional, Boeve, B., additional, Knopman, D., additional, Petersen, R., additional, and Jack, C., additional
- Published
- 2020
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14. THE EFFICACY OF THE INHERENT STRAIN METHOD IN DETERMINING RESIDUAL STRESS IN IN718 SLM SPECIMENS.
- Author
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Botha, H., Marais, D., and Kloppers, C. P.
- Subjects
- *
SELECTIVE laser melting , *NEUTRON diffraction , *RESIDUAL stresses - Abstract
This paper presents a study showing the efficacy of the inherent strain method and modifications thereof to predict residual stresses within selective laser melted components. Cubic specimens with variations in hatch rotations were produced, and the residual stress state was simulated and measured by employing the neutron diffraction technique. Variances in the simulated and observed values of stress in the samples were investigated to show the efficacy of the isotropic, orthotropic, and thermo-mechanical simulation methods. The simulations indicated a suitable prediction of the residual stress with the incorporation of hatch rotation, but as being less adept at resolving the residual stress of the components with no hatch rotation. The most accurate simulation results in the horizontal stress directions were seen for the 90° hatch rotation specimen, for which the average difference between the measured and simulated values were below 65 MPa for all simulation types. The simulations largely over-predicted Z direction compressive stresses; however, the thermo-mechanical simulation type predicted this stress with an average difference of 116, 98, and 72 MPA for the 0°, 67°, and 90° hatch rotations respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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15. 105 PET-CT findings in HIV-positive and negative patients with locally advanced cervical cancer in a south african cohort
- Author
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Simonds, H, primary, Botha, H, additional, Ellmann, A, additional, Warwick, J, additional, Doruyter, A, additional, Van der Merwe, H, additional, and Jacobson, J, additional
- Published
- 2019
- Full Text
- View/download PDF
16. Quality Control Troubles in the Rural Blood Bank: P7
- Author
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Leger, D., Botha, H., Proskiw, S., Redman, L., Pinchin, K., Baumgart, K., and Mockford, S.
- Published
- 1996
17. Justice through the J88: The doctor's role in the criminal justice system
- Author
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Rowe, K and Botha, H
- Published
- 2018
18. A Comparison of Krashen's L2 Acquisition/Learning Theory and Lozanov's Suggestopedia.
- Author
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Botha, H. Ludolph and Puhl, Carol A.
- Abstract
Stephen Krashen's L2 (Second Language) Acquisition/Learning Theory and Georgi Lozanov's method of teaching through suggestion are compared in both their underlying theories and classroom applications. The seven component hypotheses of Krashen's theory and their neurological implications are analyzed for their agreement or disagreement with the premises, principles, and means of Lozanov's Suggestopedic approach. Considerable agreement is found on issues such as input, rules, affect, teacher role, psychological needs of the language learner, and the philosophy of engaging the learner beyond the cognitive domain. The work of both is seen to affirm the recent pedagogical shift toward a richer, more open, more comfortable environment as the most effective way for educators to optimize the natural human capacity for language acquisition. It is suggested that the similarity in conclusions made by Lozanov, a physician, and Krashen, a linguist, confirms that there are common denominators in second language teaching based on sound neurological and applied linguistic principles and underscores the ingenuity of the way language is taught communicatively by Suggestopedia. (MSE)
- Published
- 1988
19. Tau uptake in agrammatic primary progressive aphasia with and without apraxia of speech
- Author
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Utianski, R. L., primary, Whitwell, J. L., additional, Schwarz, C. G., additional, Duffy, J. R., additional, Botha, H., additional, Clark, H. M., additional, Machulda, M. M., additional, Senjem, M. L., additional, Knopman, D. S., additional, Petersen, R. C., additional, Jack, C. R., additional, Lowe, V. J., additional, and Josephs, K. A., additional
- Published
- 2018
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20. Significant predictors associated with the career uncertainty of university students
- Author
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Botha, H. and Mostert, K.
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academic average ,core self-evaluation traits ,career indecision ,student engagement ,Career uncertainty ,student burnout - Abstract
The objective of this study was to determine significant predictors of career uncertainty by comparing university students with low and high career uncertainty. A non-probability quota sample (N = 782) and cross-sectional design was used. Participants were categorised as either certain (n = 644) or uncertain (n = 135). These two groups were enclosed as a dependent variable in a logistic regression analysis. In the final step of the logistic regression, significant predictors of career uncertainty were found to be: lack of information about the decision-making process; lack of information about occupations; inconsistent information due to internal conflict; exhaustion (p< 0.01); lack of information about ways of obtaining information; inconsistent information due to external conflict; cynicism; and lack of dedication (p< 0.05) http://www.journals.ac.za/index.php/sajhe http://reference.sabinet.co.za/webx/access/electronic_journals/high/high_v27_n3_a3.pdf
- Published
- 2013
21. Discourse of final-year medical students during clinical case presentations
- Author
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Botha, H, van Schalkwyk, GI, Bezuidenhout, J, and van Schalkwyk, SC
- Abstract
Introduction: The need for medical students to adopt a discourse appropriate to the field is repeatedly emphasised by teaching staff during lectures and ward rounds. The acquisition of such discourse is often not assessed, resulting in inconsistency between the levels used among students of similar academic backgrounds. Objective: The aim of this study was to determine the extent to which appropriate discourse was adopted by 9 medical students early in their final year during clinical case presentations, and to compare this usage with the students’ final results. Methods: Transcriptions of recorded case presentations by 9 students were assessed by 2 experts and a peer evaluator, using a rubric which drew on prior research in medical discourse, and included the prominent themes of terminology and thematic staging. These were then compared with their academic results. Results: Our findings show that most students are able to use the appropriate terminology when they reach their final year of study. However, our data also support the hypothesis that students with similar academic backgrounds may display considerable variation in their level of discourse. Although it appears as if the students were all beginning to shift towards a more mature form of medical discourse, the degree to which this occurs is sporadic. The apparent absence of a relationship between discursive competencies and academic achievement may suggest that the ability of assessment to encourage the adoption of disciplinary discourse is perhaps not being optimally applied, although further research is required.
- Published
- 2011
22. Trends in cervical cancer survival in Europe, 1983-1994: a population-based study
- Author
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Bielska-Lasota, M., Inghelmann, R., van de Poll-Franse, L., Capocaccia, R., Storm, H. H., Aareleid, T., Jechova, M., Rousarova, M., Hakulinen, T., Hedelin, G., Tron, I., Le Gall, E., Launoy, G., Mace-Lesec'h, J., Faivre, J., Chaplain, G., Carli, P. -M., Danzon, A., Tretarre, B., Colonna, M., Lacour, B., Raverdy, N., Berger, C., Freycon, B., Grosclaude, P., Esteve, J., Kaatsch, P., Ziegler, H., Holzel, D., Schubert Fritschle, G., Tryggvadottir, L., Berrino, F., Allemani, C., Baili, P., Ciccolallo, L., Crosignani, P., Gatta, G., Micheli, A., Sant, M., Taussig, E., Sowe, S., Ferretti, S., Conti, E., Vercelli, M., Quaglia, A., Pannelli, F., Federico, M., Artioli, M. E., Ponz De Leon, M., Benatti, P., De Lisi, V., Servente, L., Zanetti, R., Patriarca, S., Magnani, C., Pastore, G., Gafa, L., Tumino, R., Falcini, F., Budroni, M., Paci, E., Crocetti, E., Zambon, P., Guzzinati, S., Carrani, E., De Angelis, R., Roazzi, P., Santaquilani, M., Tavilla, A., Valente, F., Verdecchia, A., Dalmas, M., Langmark, F., Andersen, A., Pinheiro, P., Rachtan, J., Wronkowski, Z., Zwierko, M., Plesko, I., Obsitnikova, A., Pompe-Kirn, V., Primic-Zakelj, M., Izarzugaza, I., Martinez-Garcia, C., Garau, I., Navarro, C., Chirlaque, M. D., Ardanaz, E., Moreno, C., Galceran, J., Torrella, A., Peris-Bonet, R., Barlow, L., Moller, T., Jundt, G., Lutz, J. M., Bouchardy, C., Coebergh, J. W. W., van der Does-van den Berg, A., Visser, O., Godward, S., Coleman, M. P., Williams, E. M. I., Forman, D., Quinn, M. J., Roche, M., Edwards, S., Stiller, C., Verne, J., Moller, H., Bell, J., Botha, H., Lawrence, G., Black, R., Steward, J. A., Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)
- Subjects
MESH: Registries ,MESH : Mortality ,MESH : Aged ,Uterine Cervical Neoplasms ,Disease ,[ SDV.CAN ] Life Sciences [q-bio]/Cancer ,MESH: Aged, 80 and over ,0302 clinical medicine ,MESH : Female ,Registries ,MESH: Aged ,Cervical cancer ,Aged, 80 and over ,0303 health sciences ,education.field_of_study ,MESH: Middle Aged ,MESH : Prognosis ,Relative survival ,Absolute risk reduction ,Obstetrics and Gynecology ,Middle Aged ,MESH : Adult ,Prognosis ,MESH : Survival Rate ,3. Good health ,MESH: Uterine Cervical Neoplasms ,Europe ,Survival Rate ,Oncology ,030220 oncology & carcinogenesis ,Adenocarcinoma ,Female ,Adult ,medicine.medical_specialty ,MESH: Survival Rate ,Adolescent ,Population ,MESH : Uterine Cervical Neoplasms ,MESH : Europe ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,MESH: Prognosis ,Trends - cervical cancer - survival ,03 medical and health sciences ,MESH : Adolescent ,medicine ,Humans ,MESH : Middle Aged ,Mortality ,education ,MESH : Aged, 80 and over ,Survival rate ,030304 developmental biology ,Aged ,MESH: Adolescent ,Gynecology ,MESH: Humans ,MESH: Mortality ,business.industry ,MESH : Humans ,Cancer ,MESH: Adult ,Population-based study ,Survival ,Trends ,medicine.disease ,MESH: Europe ,business ,MESH: Female ,MESH : Registries ,Demography - Abstract
International audience; OBJECTIVE: To evaluate trends in survival from cervical cancer in Europe and in European countries participating in the EUROCARE study as a function of age, morphology and stage at diagnosis. METHODS: Relative survival and relative excess risk of death within 5 years of diagnosis, as a function of age, morphology and stage, among 73,022 women aged 15-99 years diagnosed during 1983-1994 and followed up to 1999 in each of 18 European countries participating in the EUROCARE study, using data from 34 population-based cancer registries. RESULTS: Overall five-year relative survival was 62%, rising by 2% during the period 1983-1994. The highest survival occurred in Northern and Western Europe and the lowest in Central Europe. Survival falls with age at diagnosis, but mainly for localised disease. Survival is higher for adenocarcinoma in younger women, but higher for squamous cell carcinoma in older women. The proportions of younger women, localised cancer and adenocarcinoma all increased. The main improvements in survival were for women under 65, and for metastatic disease. CONCLUSIONS: Survival in Europe has improved slowly but steadily, but the trend is not geographically uniform. Central European countries and the UK saw little or no improvement, and survival in those countries remains the lowest among participating countries in Europe. Further reduction of cervical cancer mortality in Europe may be expected from expansion of screening, and improvement in the treatment of older women, and of metastatic disease.
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- 2007
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23. Survival from rare cancer in adults: a population-based study
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Gatta, G., Ciccolallo, L., Kunkler, I., Capocaccia, R., Berrino, F., Coleman, M. P., De Angelis, R., Faivre, J., Lutz, J. M., Martinez, C., Möller, T., Sankila, R., Oberaigner, W., Storm, H. H., Aareleid, T., Jechova, M., Rousarova, M., Hakulinen, T., Hédelin, G., Tron, I., Le Gall, E., Launoy, G., Macé Lesec'h, J., Chaplain, G., Carli, P. M., Danzon, A., Tretarre, B., Colonna, M., Lacour, B., Raverdy, N., Berger, C., Freycon, B., Grosclaude, P., Estève, J., Kaatsch, P., Ziegler, H., Hölzel, D., Schubert Fritschle, G., Tryggvadottir, L., Allemani, C., Baili, P., Crosignani, P., Micheli, A., Sant, M., Taussig, E., Sowe, S., Ferretti, S., Conti, E., Vercelli, M., Quaglia, A., Pannelli, F., Federico, Massimo, Artioli, M. E., PONZ DE LEON, Maurizio, Benatti, Piero, De Lisi, V., Servente, L., Zanetti, R., Patriarca, S., Magnani, C., Pastore, G., Gafa, L., Tumino, R., Falcini, F., Budroni, M., Paci, E., Crocetti, E., Zambon, P., Guzzinati, S., Carrani, E., Roazzi, P., Santaquilani, M., Tavilla, A., Valente, F., Verdecchia, A., Dalmas, M., Langmark, F., Andersen, A., Pinheiro, P., Rachtan, J., Bielska Lasota, M., Wronkowski, Z., Zwierko, M., Pleško, I., Obsitníkováa, A., Pompe Kirn, V., Primic Zakelj, M., Izarzugaza, I., Martinez Garcia, C., Garau, I., Navarro, C., Chirlaque, M. D., Ardanaz, E., Moreno, C., Galceran, J., Torrella, A., Peris Bonet, R., Barlow, L., Jundt, G., Bouchardy, C., Coebergh, J. W. W., van der Does van den Berg, A., Visser, O., Godward, S., Williams, E. M. I., Forman, D., Quinn, M. J., Roche, M., Edwards, S., Stiller, C., Verne, J., Møller, H., Bell, J., Botha, H., Lawrence, G., Black, R., Steward, J. A., Evaluative Epidemiology Unit, Fondazione IRCCS, Department of Preventive & Predictive Medicine, Fondazione IRCCS-Istituto Nazionale dei Tumori, Registre Bourguignon des Cancers Digestifs, Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ) -Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ) -Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Registre Genevois des Tumeurs, CHU Genève, Service of Preventive Medicine, Hospital Clínico San Carlos, Madrid, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)
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Male ,Oncology ,MESH : Risk ,MESH : Aged ,[ SDV.CAN ] Life Sciences [q-bio]/Cancer ,0302 clinical medicine ,Neoplasms ,Angiosarcoma ,MESH: Neoplasms ,MESH : Female ,MESH: Quality of Health Care ,MESH: Aged ,0303 health sciences ,MESH: Risk ,MESH: Middle Aged ,Relative survival ,MESH : Quality of Health Care ,Rare cancer survival ,population-based cancer study ,international comparison ,Middle Aged ,MESH : Adult ,3. Good health ,Europe ,030220 oncology & carcinogenesis ,MESH: Survival Analysis ,MESH : Rare Diseases ,Female ,Sarcoma ,Adult ,Risk ,MESH: Rare Diseases ,medicine.medical_specialty ,Adolescent ,MESH : Male ,MESH : Europe ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,03 medical and health sciences ,Rare Diseases ,Internal medicine ,MESH : Adolescent ,medicine ,Carcinoma ,Humans ,MESH : Middle Aged ,Testicular cancer ,Survival analysis ,Aged ,Quality of Health Care ,030304 developmental biology ,MESH: Adolescent ,MESH: Humans ,Uterine sarcoma ,business.industry ,MESH : Humans ,Cancer ,MESH: Adult ,medicine.disease ,Survival Analysis ,MESH : Neoplasms ,MESH: Male ,MESH: Europe ,MESH : Survival Analysis ,business ,MESH: Female - Abstract
International audience; BACKGROUND: Rare cancers are a challenge to clinical practice, and treatment experience, even in major cancer centres to which rare cancers are usually referred, is often limited. We aimed to study the epidemiology of rare cancers in a large population of several countries. METHODS: We analysed survival by age, sex, subsite, and morphology in 57,144 adults with 14 selected rare cancers diagnosed 1983-94. Variations in survival over time and between European regions were also assessed for variations in quality of care. We also estimated the adjusted relative excess risk of death for every rare cancer. FINDINGS: Overall 5-year relative survival was good (ie, >65%) for placental choriocarcinoma (85.4% [95% CI 81.4-89.5]), thyroid medullary carcinoma (72.4% [69.2-75.5]), ovarian germ-cell cancer (73.0% [70.0-76.0]), lung carcinoid (70.1% [67.3-72.9]), and cervical adenocarcinoma (65.5% [64.3-66.6]); intermediate (ie, 35-65%) for testicular cancer at age 65 years or older (64.0% [59.3-68.7]), sarcoma of extremities (60.0% [58.9-61.2]), digestive-system endocrine cancers (55.6% [54.9-56.3]), anal squamous-cell carcinoma (53.1% [51.5-54.8]), and uterine sarcoma (43.5% [42.0-44.9]); low for carcinoma of adrenal-gland cortex (32.7% [28.3-37.2]) and bladder squamous-cell carcinoma (20.4% [18.8-22.0]); and poor for angiosarcoma of liver (6.4% [1.8-11.0]) and mesothelioma (4.7% [4.3-5.2]). Survival was usually better for women than men and poor in those aged 75 years or older. Survival significantly improved over time for ovarian germ-cell cancer, sarcomas of extremities, digestive-system endocrine tumours, anal squamous-cell carcinoma, and angiosarcoma of liver. Survival in northern Europe was higher than in the other geographic groupings for most cancers. INTERPRETATION: Because effective treatments are available for several of the rare cancers we assessed, further research is needed to ascertain why survival is lower in some European countries than in others, particularly in older patients. Audit of best practice for rare cancers with treatment protocols would be useful.
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- 2006
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24. Beyond Sexual Binaries? The German Federal Constitutional Court and the Rights of Intersex People.
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Botha, H.
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- *
INTERSEX people , *CONSTITUTIONAL courts , *UNCONSTITUTIONAL conditions doctrine (Law) - Abstract
In a recent judgment, the German Federal Constitutional Court held that it was unconstitutional to require every person's sex to be entered on the birth register, without providing for a third option for intersex persons. This article examines the intersex judgment in view of the Court's earlier jurisprudence on the rights of trans persons. It argues that this judgment was enabled, to a significant extent, by the fluid understanding of sex and gender identity shown in those judgments, and by the elaboration in those cases of the relationship between sexual freedom, human dignity and equality. It also comments on the possible relevance of the intersex judgment for South Africa, in view of some of the parallels and differences between German and South African constitutional jurisprudence. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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25. Teaching NeuroImages: Massive cerebral edema after CT myelography: An optical illusion
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Botha, H., primary, Moore, S. A., additional, and Rabinstein, A. A., additional
- Published
- 2014
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26. Clinical Reasoning: A woman with subacute progressive confusion and gait instability
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Martinez-Thompson, J. M., primary, Botha, H., additional, and Katz, B. S., additional
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- 2014
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27. Nonverbal oral apraxia in primary progressive aphasia and apraxia of speech
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Botha, H., primary, Duffy, J. R., additional, Strand, E. A., additional, Machulda, M. M., additional, Whitwell, J. L., additional, and Josephs, K. A., additional
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- 2014
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28. The role of error correction in communicative second language teaching
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Botha, H. Ludolph, primary
- Published
- 2013
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29. Suggestopaedia in theory and practice
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Botha, H. Ludolph, primary
- Published
- 2013
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30. The implementation of suggestopedic/SALT language teaching in South Africa since 1984
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Van der Vyver, Dawid H., primary and Botha, H. Ludolph, additional
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- 2013
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31. Consensus recommendations for the prevention of cervical cancer in sub-Saharan Africa
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Adewole, I F, primary, Abauleth, Y R, additional, Adoubi, I, additional, Amorissani, F, additional, Anorlu, R I, additional, Awolude, O A, additional, Botha, H, additional, Byamugisha, J K, additional, Cisse, L, additional, Diop, M, additional, Doh, S, additional, Fabamwo, A O, additional, Gahouma, D, additional, Galadanci, H S, additional, Githanga, D, additional, Magure, T M, additional, Mabogunje, C, additional, Mbuthia, J, additional, Muchiri, L W, additional, Ndiaye, O, additional, Nyakabau, A M, additional, Ojwang, S B O, additional, Ramogola-Masire, D, additional, Sekyere, O, additional, Smith, T H, additional, Taulo, F O G, additional, Wewege, A, additional, Wiredu, E, additional, and Yarosh, O, additional
- Published
- 2013
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32. The decline of the Nile crocodile population in Loskop Dam, Olifants River, South Africa
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Botha, H, primary, Van Hoven, W, additional, and Guillette Jr, LJ, additional
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- 2011
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33. Prophylactic human papillomavirus vaccination against cervical cancer: a summarised resource for clinicians
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Lindeque, B G, primary, Dreyer, G, additional, Botha, H, additional, Moodley, T, additional, Mouton, A, additional, Moodley, M, additional, Soeters, R., additional, Smith, T, additional, Cooreman, N, additional, Guidozzi, F, additional, Hoosen, A, additional, Koller, B, additional, Turner, C, additional, Moodley, J, additional, Godi, N P, additional, Voyi, K, additional, Slavik, T, additional, Whittaker, J, additional, Williamsen, A, additional, and Rogers, L, additional
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- 2011
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34. Suicide cases investigated at the state mortuary in Bloemfontein, 2003–2007
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Stark, K, primary, Joubert, G, additional, Struwig, M, additional, Pretorius, M, additional, Van der, Merwe N, additional, Botha, H, additional, Kotzé, J, additional, and Krynauw, D, additional
- Published
- 2010
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35. Generation and size distribution of sediment eroded in a small-scale catchment of the Western Cape (South Africa)
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Jovanovic, N. Z., primary, Bugan, R. D. H., additional, Petersen, C., additional, De Clercq, W. P., additional, Rozanov, A., additional, and Botha, H., additional
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- 2010
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36. An investigation of self-appraised cognition versus measured cognition
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Botha, H L, primary and Du Plessis, S A, additional
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- 2008
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37. A new solution for a South African catastrophe?
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Botha, H, primary
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- 2006
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38. Omental teratoma in supernumerary ovary, in a pregnancy complicated by pre-eclampsia and HIV : case report
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Patel, F, primary and Botha, H, additional
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- 2005
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39. Polycystic liver disease - a disease entity presenting as part of autosomal-dominant polycystic kidney disease
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Boonzaaier-Botha, H., primary and Cock, C., additional
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- 2004
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40. Mining Wellness and Performance Data to Identify At-Risk First-Year Engineering Students.
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du Plessis, S. A. and Botha, H. L.
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DATA mining , *ENGINEERING student research , *MANAGEMENT information systems , *ARTIFICIAL neural networks , *CLUSTER analysis (Statistics) - Abstract
Management information systems, cluster analysis and neural network prediction models were used to mine performance and wellness data of first-year engineering students to identify factors that may cause underperformance. Weighted first-year averages, first and second-year retention rates, as well as throughput rates of the last ten cohorts, were analysed per race, gender, accommodation type and Grade 12 level. Sophisticated management information systems successfully identified groups that were at risk of underperformance and highlighted the possible existence of stereotype threat. Wellness data obtained from a profiling questionnaire and biographical information were combined with Grade 12 and university performance data in neural network models to predict first-year success, first- and secondyear retention and success in the minimum period. Correct classification rates of above 80% were obtained and the wellness related variables played a very significant role in these predictions. A cluster analysis confirmed the relationship between wellness and academic performance. [ABSTRACT FROM AUTHOR]
- Published
- 2012
41. An investigation of self-appraised cognition versus measured cognition.
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Botha, H. L. and du Plessis, S. A.
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UNIVERSITIES & colleges ,RATING of students ,ACADEMIC achievement ,EDUCATIONAL evaluation ,COGNITION ,QUESTIONNAIRES - Abstract
The central question in this investigation was whether there is a common factor providing some explanation why students with similar final school results perform differently at first-year university level. The underlying hypothesis was: the more students believe they are cognitively capable and equipped to achieve success at university level, the better they perform academically. A description is provided of a questionnaire used in this investigation which also forms part of a tracking system at Stellenbosch University. With the results of this questionnaire for three cohorts of first-year students of the years 2002, 2003 and 2004 grouped together in subgroups (based on final school year performance and including a group of Extended Degree Programme students), it is demonstrated that there is a strong relationship between high self-appraised cognition as measured in the questionnaire and successful performance at university level. These findings are corroborated by international research which is referred to in the article. The implications of this investigation are far-reaching in terms of the necessity to regard a student holistically, to realise the importance of how students appraise themselves cognitively, and the need to pay special attention to building a healthy self-concept. [ABSTRACT FROM AUTHOR]
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- 2007
42. The experiential modification of a computer software package for graphing algebraic functions.
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Maree, J. G., Scholtz, S., Botha, H. J., and van Putten, S.
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COMPUTER software ,GRAPH theory ,ALGEBRAIC functions ,FUNCTIONAL analysis ,EDUCATION of mathematics teachers ,MATHEMATICS education ,EDUCATION - Abstract
Graphing software and graphics calculators are widely used in most of the world's larger economies to facilitate students' development of conceptual understanding of mathematical function analysis. This has proved to be an extremely effective vehicle in making complex mathematics more accessible to the majority of learners. In contrast, its use in South Africa has been limited. Possible reasons may be the cost of graphics calculators, limited availability of supporting study material, and teachers who lack the necessary skills and confidence. At the School of Teacher Training, University of Pretoria, the Master Grapher for Windows was introduced by way of a pilot study in an effort to adapt the training of mathematics teachers-in-training to meet the specific needs of these students. The experiences of five students were monitored. The aim is to enhance and facilitate trainee-teachers' understanding of mathematics, but also to equip them to develop learner-centred, group-based learning experiences in future teaching situations. Action research was implemented to develop the course. [ABSTRACT FROM AUTHOR]
- Published
- 2005
43. Student counselling and development services in higher education institutions in South Africa.
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Botha, H. L., Brand, H. J., Cilliers, C. D., Davidow, A., de Jager, A. C., and Smith, D.
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EDUCATIONAL counseling ,VOCATIONAL guidance ,HIGHER education ,UNIVERSITIES & colleges ,STUDENTS - Abstract
This article discusses student counselling and development services as on indispensable and integral part of higher education institutions. The value of such services is highlighted by drawing on theoretical considerations as well as examples from current research perspectives, both internationally and nationally. Because of its past history and present conditions, South Africa has specific higher education needs, for example dealing with large numbers of students who had inadequate school preparation and who consequently experience numerous barriers to teaming. These needs ore discussed in terms of the way that student counselling contributes towards ensuring that students receive the necessary support to study successfully and to enter the world of work as well-adjusted and well-prepared citizens of the new South Africa. [ABSTRACT FROM AUTHOR]
- Published
- 2005
44. School results and access test results as indicators of first-year performance at university.
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Bothma, A., Botha, H. L., and Le Roux, N. J.
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- *
UNIVERSITY & college admission , *HIGHER education , *STUDENTS , *QUANTITATIVE research - Abstract
The goals set by the National Plan for Higher Education, the fact that many schools are still severely disadvantaged as well as far-reaching changes in the school system demand that South African universities urgently reconsider their admission procedures. Redesigning admission procedures calls for a thorough understanding of the interrelationships between school marks, results in existing access tests and first-year university performance. These interrelationships were statistically investigated in the case of the 1999, 2000 and 2001 intake groups, who were compelled to write access tests before being admitted to Stellenbosch University. The results of this investigation confirm an alarming degree of unpreparedness among many prospective students regarding what is expected of them at university. This is aggravated by school marks creating a totally unrealistic expectation of performance in the first year at university. It is emphasised that schools and authorities dealing with admission of prospective students at universities should be cognisant of the findings reported here. Furthermore, the statistical analyses demonstrate several novel techniques for investigating the interrelationship between school marks, access test results and university performance. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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45. Mining wellness and performance data to identify At-Risk first-Year engineering students
- Author
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Stan Du Plessis and Botha, H. L.
46. Serum screening for Down's syndrome.
- Author
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Burton, P., primary, Kurinczuk, J. J., additional, Botha, H., additional, Lowry, A., additional, and Sheldon, T. A., additional
- Published
- 1989
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47. Bridging and academic support for first year university students: preparation of the lecturing staff
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Botha, H.L. and Cilliers, C.D.
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Academically disadvantaged student ,medium of instruction ,first year university students ,academic support ,lecturing staff ,Language and Literature ,African languages and literature ,PL8000-8844 - Abstract
Academically disadvantaged students encounter many problems in coping with a medium of instruction other than their own mother tongue at tertiary level. The authors established additional needs, e.g. the upgrading of thinking and study skills, which were, in the programme under discussion, addressed simultaneously with the language component. They outline the plan, structure and implementation of a project consisting of a seven-week bridging course and an academic support programme lasting a full academic year. A blueprint for an Academic Preparational and Support Programme is discussed. Conclusions and recommendations follow. Studente met akademiese agterstande ondervind baie probleme op tersiere vlak met die onderrigmedium wat nie hul moedertaal is nie. Die skrywers het addisionele behoeftes bepaal, soos die opgradering van denk- en studievaardighede, wat saam met die taal aandag geniet het in die program onder bespreking. Hulle verstrek die plan, struktuur en implementering van 'n projek wat bestaan uit 'n sewe-week brugkursus en 'n akademiese ondersteuningsprogram vir die duur van 'n volle akademiese jaar. 'n Meesterplan vir 'n Akademiese Voorbereidings- en Ondersteuningsprogram word bespreek. Gevolgtrekkings en aanbevelings sluit die artikel af
- Published
- 1991
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48. Statistical properties of indicators of first-year performance at university.
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Le Roux, N. J., Bothma, A., and Botha, H. L.
- Subjects
- *
UNIVERSITY & college admission , *MATHEMATICAL ability , *DECISION making , *COLLEGE applications , *COLLEGE preparation programs , *UNIVERSITY & college entrance requirements , *COLLEGE students - Abstract
Appraisal of admission procedures is a matter of urgency for South African universities, as well as for schools producing the prospective students. In this article the focus is on how various statistical procedures can be used to assess admission measures. Properties of the statistical distributions related to school results, access test results and first-year university performance are vital for decision-makers in schools preparing the prospective students and for those who wish to refine university admission procedures. These properties are scrutinised for the 1999, 2000 and 2001 intake groups required to write access tests before being admitted to Stellenbosch University. Using kernel density estimates the univariate distributions of all variables concerned are described in detail. Bagplots are proposed for visual displays of important features like location, spread, correlation, skewness, outliers and tails of bivariate distributions composed of university average performance and a school result or access test variable. Evidence is provided that certain access tests (Mathematics, Science and Numeracy Skills) have statistical distributions similar to that of average first-year university performance, but that average school marks could not be trusted to discriminate between potentially successful and unsuccessful university students. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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49. Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration
- Author
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Joseph E. Parisi, Nirubol Tosakulwong, Hugo Botha, Keith A. Josephs, Christopher G. Schwarz, Gaël Chételat, Clifford R. Jack, Peter R. Martin, Melissa E. Murray, Alexandre Bejanin, Bradley F. Boeve, Matthew L. Senjem, Kejal Kantarci, Caterina Giannini, Dennis W. Dickson, Jennifer L. Whitwell, David S. Knopman, Ronald C. Petersen, Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bejanin A., Murray M.E., Martin P., Botha H., Tosakulwong N., Schwarz C.G., Senjem M.L., Chetelat G., Kantarci K., Jack C.R., Boeve B.F., Knopman D.S., Petersen R.C., Giannini C., Parisi J.E., Dickson D.W., Whitwell J.L., and Josephs K.A.
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Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,TDP-43 ,[SDV]Life Sciences [q-bio] ,Hippocampus ,tau Proteins ,Neuropathology ,Grey matter ,Temporal lobe ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,mental disorders ,medicine ,Humans ,Dementia ,tau ,Prospective Studies ,Gray Matter ,ComputingMilieux_MISCELLANEOUS ,Aged ,Aged, 80 and over ,neuropathology ,Amyloid beta-Peptides ,β-amyloid ,business.industry ,Brain ,nutritional and metabolic diseases ,Neurodegenerative Diseases ,radiological-pathological study ,Original Articles ,Frontotemporal lobar degeneration ,medicine.disease ,Entorhinal cortex ,Magnetic Resonance Imaging ,Temporal Lobe ,nervous system diseases ,DNA-Binding Proteins ,030104 developmental biology ,medicine.anatomical_structure ,Frontotemporal Dementia ,Disease Progression ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Over the past decade, the transactive response DNA-binding protein of 43 kDa (TDP-43) has been recognized as a major protein in normal and pathological ageing, increasing the risk of cognitive impairment and dementia. In conditions distinct from the frontotemporal lobar degenerations, TDP-43 appears to progress in a stereotypical pattern. In the present study, we aimed at providing a better understanding of the effects of TDP-43 and other age-related neuropathologies on cross-sectional grey matter volume in a cohort of non-FTLD subjects. We included 407 individuals with an antemortem MRI and post-mortem brain tissue from the Mayo Clinic Alzheimer's Disease Research Center, Mayo Clinic Alzheimer's Disease Patient Registry, or the Mayo Clinic Study of Aging. All individuals were assigned pathological stages for TDP-43, tau, amyloid-β, Lewy bodies, argyrophilic grain disease and vascular pathologies. Robust regressions were performed in regions of interest and voxel-wise to explore the relationships between TDP-43 stages and grey matter volume while controlling for other pathologies. Grey matter volumes adjusted for pathological and demographic variables were also computed for each TDP-43-positive case to further characterize the sequential involvement of brain structures associated with TDP-43, irrespective of the TDP-43 staging scheme. Robust regressions showed that the extent of TDP-43 pathology was associated with the extent of grey matter atrophy. Specifically, we found that the volume in medial temporal regions (i.e. amygdala, entorhinal cortex, hippocampus) decreased progressively with advancing TDP-43 stages. Importantly, these effects were of similar magnitude to those related to tau stages. Additional analyses using adjusted grey matter volume demonstrated a sequential pattern of volume loss associated with TDP-43, starting within the medial temporal lobe, followed by early involvement of the temporal pole, and eventually encompassing additional temporal and frontal regions. Altogether, this study demonstrates the major and independent contribution of TDP-43 pathology on neurodegeneration and provides further insight into the regional distribution of TDP-43 in non-FTLD subjects. Along with previous studies, these findings emphasized the importance of targeting TDP-43 in future clinical trials to prevent its detrimental effect on grey matter volume and, eventually, cognition.
- Published
- 2019
- Full Text
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50. The emergence of temporality: from restricted linguistic systems to early human language
- Author
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Benazzo, Sandra, Savoirs, Textes, Langage (STL) - UMR 8163 (STL), Université de Lille-Centre National de la Recherche Scientifique (CNRS), In R.P. Botha & H. de Swart (éds)., and Projet NIAS (2004-2006) « Restricted Linguistic Systems as Windows on Language Genesis », coordonné par R. Botha (Stellebosch University) et financé par NIAS (Netherlands Institute for Advanced Study), Wassenaar, Pays-Bas.
- Subjects
language evolution ,second language varieties ,home signs ,[SHS.LANGUE]Humanities and Social Sciences/Linguistics ,temporality - Abstract
International audience; Temporality is a fundamental category of human cognition which, in contrast to animal communication, is encoded in elaborate ways in every modern language. Following the windows approach, this paper investigates the development of temporal relations in simple linguistic systems of different natures – early varieties of untutored L2 learners and homesign systems of deaf subjects – and discusses the possible implications for language evolution. The comparison of linguistic systems arising in quite different circumstances allows for the identification of recurrent developmental patterns and thus provides a more robust empirical basis for projections on early language.
- Published
- 2009
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