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2. A differential therapeutic consideration for use of corticosteroids according to established COVID-19 clinical phenotypes in critically ill patients

Author

Moreno, G., Ruiz-Botella, M., Martín-Loeches, I., Gómez Álvarez, J., Jiménez Herrera, M., Bodí, M., Armestar, F., Marques Parra, A., Estella, Á., Trefler, S., Jorge García, R., Murcia Paya, J., Vidal Cortes, P., Díaz, E., Ferrer, R., Albaya-Moreno, A., Socias-Crespi, L., Bonell Goytisolo, J.M., Sancho Chinesta, S., Loza, A., Forcelledo Espina, L., Pozo Laderas, J.C., deAlba-Aparicio, M., Sánchez Montori, L., Vallverdú Perapoch, I., Hidalgo, V., Fraile Gutiérrez, V., Casamitjana Ortega, A.M., Martín Serrano, F., Nieto, M., Blasco Cortes, M., Marín-Corral, J., Solé-Violán, J., and Rodríguez, A.

Published
2023
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9. Light spectrum effects on rocket and lamb's lettuce cultivated in a vertical indoor farming system

Author

Agencia Nacional de Investigación y Desarrollo (Chile), Martínez, Vicente [0000-0002-3388-3116], Frutos-Totosa, A., Hernández-Adasme, C., Martínez, Vicente, Mestre, Teresa C., Diaz-Mula, Huertas M., Botella, M. Ángeles, Flores, Pilar, Martínez-Moreno, Alejandro, Agencia Nacional de Investigación y Desarrollo (Chile), Martínez, Vicente [0000-0002-3388-3116], Frutos-Totosa, A., Hernández-Adasme, C., Martínez, Vicente, Mestre, Teresa C., Diaz-Mula, Huertas M., Botella, M. Ángeles, Flores, Pilar, and Martínez-Moreno, Alejandro

Abstract

Rocket and lamb's lettuce are new leafy vegetables whose consumption in salads is increasing, especially as ready-to-eat products. These plants are often cultivated in greenhouses under artificial light, and are very important due to their pleasant taste, texture, and nutritional value to humans. The present study analyzes the effects of light quality provided by light emitting diodes (LEDs) on the yield and quality of different leafy vegetable species. Lamb's lettuce and rocket plants were grown in the same conditions under 4 light spectrums color fractions (NS-12, AP57, AP673L, and G2) for 27 and 37 days, respectively. Then fresh and dry weight, chlorophyll fluorescence, and chromatic characteristics were determined. The leaf quality of lamb's lettuce and rocket was characterized by measurements of the contents of carbohydrates, organic acids, and amino acids in leaves. Vegetative growth was significantly influenced by light quality and was species-dependent, and treatment with the highest proportion of Red:Blue light (G2) produced the highest fresh weight and maximum efficiency of PSII. The results of the chlorophyll fluorescence parameters were more influenced by the species rather than by the spectrum lights, except for the efficiency of PSII, which was higher in treatments with the lowest Red: Far-red ratio (AP67 and G2). G2 light spectrum reduces chlorophyll and carotenoid content compared to other treatments. Among all the primary metabolites analyzed, non-structural carbohydrates were the most dependent on light quality. Generally, the lights with the greatest effect on the parameters analyzed were those with higher Red:Blue ratios and a higher far-red fraction. No effect of light spectra on glutamate concentration was observed. However, a concentration increase was observed in treatments with a higher proportion of far-red light. Regarding organics acids, the different light spectrums did not affect the concentration of the majority of acids (citrate and m

Published
2023

10. Artificial Intelligence & Creativity: A Manifesto for Collaboration

Author

Vinchon, F., Lubart, T., Bartolotta, Sabrina, Gironnay, V., Botella, M., Bourgeois-Bougrine, S., Burkhardt, J. -M., Bonnardel, N., Corazza, G. E., Glaveanu, Vlad Petre, Hanchett Hanson, M., Ivcevic, Z., Karwowski, M., Kaufman, J. C., Okada, T., Reiter-Palmon, R., Gaggioli, Andrea, Bartolotta S., Glaveanu V., Gaggioli A. (ORCID:0000-0001-7818-7598), Vinchon, F., Lubart, T., Bartolotta, Sabrina, Gironnay, V., Botella, M., Bourgeois-Bougrine, S., Burkhardt, J. -M., Bonnardel, N., Corazza, G. E., Glaveanu, Vlad Petre, Hanchett Hanson, M., Ivcevic, Z., Karwowski, M., Kaufman, J. C., Okada, T., Reiter-Palmon, R., Gaggioli, Andrea, Bartolotta S., Glaveanu V., and Gaggioli A. (ORCID:0000-0001-7818-7598)

Abstract

With the advent of artificial intelligence (AI), the field of creativity faces new opportunities and challenges. This manifesto explores several scenarios of human–machine collaboration on creative tasks and proposes “fundamental laws of generative AI” to reinforce the responsible and ethical use of AI in the creativity field. Four scenarios are proposed and discussed: “Co-Cre-AI-tion,” “Organic,” “Plagiarism 3.0,” and “Shut down,” each illustrating different possible futures based on the collaboration between humans and machines. In addition, we have incorporated an AI-generated manifesto that also highlights important themes, ranging from accessibility and ethics to cultural sensitivity. The fundamental laws proposed aim to prevent AIs from generating harmful content and competing directly with humans. Creating labels and laws are also highlighted to ensure responsible use of AIs. The positive future of creativity and AI lies in a harmonious collaboration that can benefit everyone, potentially leading to a new level of creative productivity respecting ethical considerations and human values during the creative process.

Published
2023

12. Créativité et cognition

Author

Botella, M, Pichot, N, Volle, E, Cassotti, M, Lubart, T, Bonnardel, N, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de psychologie du développement et de l'éducation de l'enfant (LaPsyDÉ), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Centre d'études et de recherches appliquées à la gestion (CERAG), Université Pierre Mendès France - Grenoble 2 (UPMF)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Psychologie de la Connaissance, du Langage et de l'Émotion (PsyCLÉ), Aix Marseille Université (AMU), Bonnardel, N., Girandola, F., Bonetto, E., Lubart, and T.

Subjects
[SCCO]Cognitive science
Abstract

International audience

Published
2023

14. Patients’ and physicians’ preferences for type 2 diabetes mellitus treatments in Spain and Portugal: a discrete choice experiment

Author

Morillas C, Feliciano R, Catalina PF, Ponte C, Botella M, Rodrigues J, Esmatjes E, Lafita J, Lizán L, Llorente I, Morales C, Navarro-Pérez J, Orozco-Beltran D, Paz S, Ramirez de Arellano A, Cardoso C, and Tribaldos Causadias M

Subjects
Medicine (General), R5-920
Abstract

Carlos Morillas,1 Rosa Feliciano,2 Pablo Fernández Catalina,3 Carla Ponte,4 Marta Botella,5 João Rodrigues,6 Enric Esmatjes,7 Javier Lafita,8 Luis Lizán,9 Ignacio Llorente,10 Cristóbal Morales,11 Jorge Navarro-Pérez,12 Domingo Orozco-Beltran,13 Silvia Paz,9 Antonio Ramirez de Arellano,14 Cristina Cardoso,15 Maribel Tribaldos Causadias9 1Hospital Universitario Dr Peset, Valencia, Spain; 2USF São Domingos, Santarém, Portugal; 3Hospital Montecelo de Pontevedra, Galicia, Spain; 4USF Porta do Sol, Matosinhos, Portugal; 5Hospital Universitario Principe de Asturias, Madrid, Spain; 6USF Serra da Lousã, Lousã, Portugal; 7Hospital Clinic, Barcelona, Spain; 8Hospital de Navarra, Navarra, Spain; 9Outcomes’10, Universidad Jaume I, Castellón, Spain; 10Hospital Universitario Nuestra Señora de la Candelaria, Canarias, Spain; 11Hospital Universitario Virgen de la Macarena, Sevilla, Spain; 12INCLIVA, CIBERESP, Universidad de Valencia, Valencia, Spain; 13Sociedad Española de Medicina Familiar y Comunitaria, Valencia, Spain; 14Novo Nordisk EU-HEOR Europe, Madrid, Spain; 15Novo Nordisk, Lisbon, Portugal Objective: To assess Spanish and Portuguese patients’ and physicians’ preferences regarding type 2 diabetes mellitus (T2DM) treatments and the monthly willingness to pay (WTP) to gain benefits or avoid side effects.Methods: An observational, multicenter, exploratory study focused on routine clinical practice in Spain and Portugal. Physicians were recruited from multiple hospitals and outpatient clinics, while patients were recruited from eleven centers operating in the public health care system in different autonomous communities in Spain and Portugal. Preferences were measured via a discrete choice experiment by rating multiple T2DM medication attributes. Data were analyzed using the conditional logit model.Results: Three-hundred and thirty (n=330) patients (49.7% female; mean age 62.4 [SD: 10.3] years, mean T2DM duration 13.9 [8.2] years, mean body mass index 32.5 [6.8] kg/m2, 41.8% received oral + injected medication, 40.3% received oral, and 17.6% injected treatments) and 221 physicians from Spain and Portugal (62% female; mean age 41.9 [SD: 10.5] years, 33.5% endocrinologists, 66.5% primary-care doctors) participated. Patients valued avoiding a gain in bodyweight of 3 kg/6 months (WTP: €68.14 [95% confidence interval: 54.55–85.08]) the most, followed by avoiding one hypoglycemic event/month (WTP: €54.80 [23.29–82.26]). Physicians valued avoiding one hypoglycemia/week (WTP: €287.18 [95% confidence interval: 160.31–1,387.21]) the most, followed by avoiding a 3 kg/6 months gain in bodyweight and decreasing cardiovascular risk (WTP: €166.87 [88.63–843.09] and €154.30 [98.13–434.19], respectively). Physicians and patients were willing to pay €125.92 (73.30–622.75) and €24.28 (18.41–30.31), respectively, to avoid a 1% increase in glycated hemoglobin, and €143.30 (73.39–543.62) and €42.74 (23.89–61.77) to avoid nausea.Conclusion: Both patients and physicians in Spain and Portugal are willing to pay for the health benefits associated with improved diabetes treatment, the most important being to avoid hypoglycemia and gaining weight. Decreased cardiovascular risk and weight reduction became the third most valued attributes for physicians and patients, respectively. Keywords: diabetes, discrete choice model, preferences, willingness to pay, hypoglycemia, weight, cardiovascular risk, HbA1c

Published
2015

17. Deploying unsupervised clustering analysis to derive clinical phenotypes and risk factors associated with mortality risk in 2022 critically ill patients with COVID-19 in Spain

Author

Rodríguez A, Ruiz-Botella M, Martín-Loeches I, Jimenez Herrera M, Solé-Violan J, Gómez J, Bodí M, Trefler S, Papiol E, Díaz E, Suberviola B, Vallverdu M, Mayor-Vázquez E, Albaya Moreno A, Canabal Berlanga A, Sánchez M, Del Valle Ortíz M, Ballesteros JC, Martín Iglesias L, Marín-Corral J, López Ramos E, Hidalgo Valverde V, Vidaur Tello LV, Sancho Chinesta S, Gonzáles de Molina FJ, Herrero García S, Sena Pérez CC, Pozo Laderas JC, Rodríguez García R, Estella A, Ferrer R, COVID-19 SEMICYUC Working Group, Institut Català de la Salut, [Rodríguez A] ICU Hospital Universitario Joan XXIII/IISPV/URV, Mallafre Guasch 4, 43007 Tarragona, Spain. CIBERESUCICOVID, Barcelona, Spain. [Ruiz-Botella M, Gómez J] Tarragona Health Data Research Working Group (THeDaR), ICU Hospital Universitario Joan XXIII, Tarragona, Spain. [Martín-Loeches I] Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St. James’s Hospital, Dublin, Ireland. [Jimenez Herrera M] ICU Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain. [Solé-Violan J] ICU Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain. [Papiol E, Ferrer R] Unitat de Cures Intensives (UCI), Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Male, COVID-19 (Malaltia) - Mortalitat, Disease, Critical Care and Intensive Care Medicine, 01 natural sciences, law.invention, 0302 clinical medicine, law, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Cluster Analysis, 030212 general & internal medicine, education.field_of_study, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Middle Aged, Prognosis, Intensive care unit, Phenotype, Phenotypes, SOFA score, Female, Risk assessment, medicine.medical_specialty, Prognosi, Critical Illness, Population, Risk Assessment, 03 medical and health sciences, Other subheadings::Other subheadings::Other subheadings::/mortality [Other subheadings], Internal medicine, Machine learning, medicine, Humans, 0101 mathematics, Diagnosis::Prognosis [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], education, diagnóstico::pronóstico [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Machine learning, Phenotypes, Prognosis, Risk factors, Severe SARS-CoV-2 infection, Aged, Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad [Otros calificadores], Receiver operating characteristic, business.industry, Research, 010102 general mathematics, COVID-19, lcsh:RC86-88.9, Severe SARS-CoV-2 infection, Risk factors, Spain, Observational study, business
Abstract

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Fenotips; Factors de risc; Infecció greu per SARS-CoV-2 Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Fenotipos; Factores de riesgo; Infección grave por SARS-CoV-2 Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Phenotypes; Risk factors; Severe SARS-CoV-2 infection Background The identification of factors associated with Intensive Care Unit (ICU) mortality and derived clinical phenotypes in COVID-19 patients could help for a more tailored approach to clinical decision-making that improves prognostic outcomes. Methods Prospective, multicenter, observational study of critically ill patients with confirmed COVID-19 disease and acute respiratory failure admitted from 63 ICUs in Spain. The objective was to utilize an unsupervised clustering analysis to derive clinical COVID-19 phenotypes and to analyze patient’s factors associated with mortality risk. Patient features including demographics and clinical data at ICU admission were analyzed. Generalized linear models were used to determine ICU morality risk factors. The prognostic models were validated and their performance was measured using accuracy test, sensitivity, specificity and ROC curves. Results The database included a total of 2022 patients (mean age 64 [IQR 5–71] years, 1423 (70.4%) male, median APACHE II score (13 [IQR 10–17]) and SOFA score (5 [IQR 3–7]) points. The ICU mortality rate was 32.6%. Of the 3 derived phenotypes, the A (mild) phenotype (537; 26.7%) included older age ( 65 years), high severity of illness and a higher likelihood of development shock. Crude ICU mortality was 20.3%, 25% and 45.4% for A, B and C phenotype respectively. The ICU mortality risk factors and model performance differed between whole population and phenotype classifications. Conclusion The presented machine learning model identified three clinical phenotypes that significantly correlated with host-response patterns and ICU mortality. Different risk factors across the whole population and clinical phenotypes were observed which may limit the application of a “one-size-fits-all” model in practice. This study was supported by the Spanish Intensive Care Society (SEMICYUC) and Ricardo Barri Casanovas Foundation. The study sponsors have no role in the study design, data collection, data analysis, data interpretation, or writing of the report.

Published
2021

18. A Differential Therapeutic consideration for use of Corticosteroids according to Established COVID-19 Clinical Phenotypes in Critically ill Patients

Author

Moreno G, Ruiz-Botella M, Martín-Loeches I, Alvarez JG, Herrera MJ, Bodí M, Armestar F, Parra AM, Estella Á, Trefler S, García RJ, Paya JM, Cortes PV, Díaz E, Ferrer R, Albaya-Moreno A, Socias-Crespi L, Goytisolo JMB, Chinesta SS, Loza A, Espina LF, Laderas JCP, deAlba-Aparicio M, Montori LS, Perapoch IV, Hidalgo V, Gutiérrez VF, Ortega AMC, Serrano FM, Nieto M, Cortes MB, Marín-Corral J, Solé-Violán J, Rodríguez A, and on behalf COVID-19 SEMICYUC working Group

Subjects
COVID-19, Corticosteroids, ICU Mortality, Phenotypes, SARS-CoV2-pneumonia, unsupervised clustering
Abstract

To determine if the use of corticosteroids was associated with Intensive Care Unit (ICU) mortality among whole population and pre-specified clinical phenotypes.

Published
2021

19. Deploying unsupervised clustering analysis to derive clinical phenotypes and risk factors associated with mortality risk in 2022 critically ill patients with COVID-19 in Spain

Author

Universitat Rovira i Virgili, Rodríguez A; Ruiz-Botella M; Martín-Loeches I; Jimenez Herrera M; Solé-Violan J; Gómez J; Bodí M; Trefler S; Papiol E; Díaz E; Suberviola B; Vallverdu M; Mayor-Vázquez E; Albaya Moreno A; Canabal Berlanga A; Sánchez M; del Valle Ortíz M; Ballesteros JC; Martín Iglesias L; Marín-Corral J; López Ramos E; Hidalgo Valverde V; Vidaur Tello LV; Sancho Chinesta S; Gonzáles de Molina FJ; Herrero García S; Sena Pérez CC; Pozo Laderas JC; Rodríguez García R; Estella A; Ferrer R; Loza A; Zapata DM; Torres ID; Cuadros SI; Nuñez MR; Pérez MLC; Ramos JG; Casas AV; Cantón ML, Universitat Rovira i Virgili, and Rodríguez A; Ruiz-Botella M; Martín-Loeches I; Jimenez Herrera M; Solé-Violan J; Gómez J; Bodí M; Trefler S; Papiol E; Díaz E; Suberviola B; Vallverdu M; Mayor-Vázquez E; Albaya Moreno A; Canabal Berlanga A; Sánchez M; del Valle Ortíz M; Ballesteros JC; Martín Iglesias L; Marín-Corral J; López Ramos E; Hidalgo Valverde V; Vidaur Tello LV; Sancho Chinesta S; Gonzáles de Molina FJ; Herrero García S; Sena Pérez CC; Pozo Laderas JC; Rodríguez García R; Estella A; Ferrer R; Loza A; Zapata DM; Torres ID; Cuadros SI; Nuñez MR; Pérez MLC; Ramos JG; Casas AV; Cantón ML

Abstract

© 2021, The Author(s). Background: The identification of factors associated with Intensive Care Unit (ICU) mortality and derived clinical phenotypes in COVID-19 patients could help for a more tailored approach to clinical decision-making that improves prognostic outcomes. Methods: Prospective, multicenter, observational study of critically ill patients with confirmed COVID-19 disease and acute respiratory failure admitted from 63 ICUs in Spain. The objective was to utilize an unsupervised clustering analysis to derive clinical COVID-19 phenotypes and to analyze patient’s factors associated with mortality risk. Patient features including demographics and clinical data at ICU admission were analyzed. Generalized linear models were used to determine ICU morality risk factors. The prognostic models were validated and their performance was measured using accuracy test, sensitivity, specificity and ROC curves. Results: The database included a total of 2022 patients (mean age 64 [IQR 5–71] years, 1423 (70.4%) male, median APACHE II score (13 [IQR 10–17]) and SOFA score (5 [IQR 3–7]) points. The ICU mortality rate was 32.6%. Of the 3 derived phenotypes, the A (mild) phenotype (537; 26.7%) included older age (< 65 years), fewer abnormal laboratory values and less development of complications, B (moderate) phenotype (623, 30.8%) had similar characteristics of A phenotype but were more likely to present shock. The C (severe) phenotype was the most common (857; 42.5%) and was characterized by the interplay of older age (> 65 years), high severity of illness and a higher likelihood of development shock. Crude ICU mortality was 20.3%, 25% and 45.4% for A, B and C phenotype respectively. The ICU mortality risk factors and model performance differed between whole population and phenoty

Published
2021

27. Acceptance and knowledge of evolutionary theory among third-year university students in Spain

Author

Gefaell, Juan, Prieto, Tamara, Abdelaziz, M., Álvarez, Inés, Antón, J., Arroyo, J., Bella, J.L., Botella, M., Bugallo, Anxela, Claramonte, V., Gijón, J., Lizarte, E., Maroto, R.M., Megías, M., Milá, Borja, Ramón, C., Vila, M., Rolán-Alvarez, E., Gefaell, Juan, Prieto, Tamara, Abdelaziz, M., Álvarez, Inés, Antón, J., Arroyo, J., Bella, J.L., Botella, M., Bugallo, Anxela, Claramonte, V., Gijón, J., Lizarte, E., Maroto, R.M., Megías, M., Milá, Borja, Ramón, C., Vila, M., and Rolán-Alvarez, E.

Abstract

The theory of evolution is one of the greatest scientific achievements in the intellectual history of humankind, yet it is still contentious within certain social groups. Despite being as robust and evidence-based as any other notable scientific theory, some people show a strong reluctance to accept it. In this study, we used the Measure of Acceptance of the Theory of Evolution (MATE) and Knowledge of Evolution Exam (KEE) questionnaires with university students from four academic degree programs (Chemistry, English, History, and Biology) of ten universities from Spain to measure, respectively, acceptance and knowledge of evolutionary theory among third-year undergraduate students (n = 978; n = 981). Results show that acceptance of evolution is relatively high (87.2%), whereas knowledge of the theory is moderate (5.4 out of 10) although there are differences across degrees (Biology>Chemistry>History>English), and even among various universities (ranging from 4.71 to 5.81). Statistical analysis reveals that knowledge of evolutionary theory among Biology students is partially explained by the relative weight of evolutionary themes within the curriculum, suggesting that an increase in the number of hours dedicated to this topic could have a direct influence on students’ knowledge of it. We also found that religion may have a significant—although relatively small—negative influence on evolutionary theory acceptance. The moderate knowledge of evolution in our undergraduate students, together with the potential problem of acceptance in certain groups, suggests the need for a revision of the evolutionary concepts in the teaching curricula of our students since primary school.

Published
2020

32. Abstracts of papers and posters advanced activities in pharmaceutical care 24th European Symposium on Clinical Pharmacy

Author

Nahata, M. C., Bootman, J. L., Zadák, Z., Soeters, P. B., Goldberg, Laurence A., Stremetzne, S., Jaehde, U., Streit, M., Kreuser, E. D., Thiel, E., Schunack, W., Calvert, R. T., Feely, M., Chrystyn, H., Mangues M. A., Ginovart G., Moral M. A., Lopes A. P., Farré R., Demestre X., Altirriba O., Kloft, Ch., Beyer, J., Steuer, J., Siegert, W., Bever, J., Bialer, M., Sussan, S., Salach, O. Abu, Danenberg, H. D., Laor, A., Barnett, M. I., Cosslett, A. G., Cohen, J., Marini, P., Bassi, C., Bonzanini, A., Cassani, T., Dalle Ore, G., Mangiante, G., Scroccaro, G., Kaczan, M., Eriksen, J., Toft, B., Jandová, M., Vlček, J., Klemerová, V., Sobotka, L., Ayestarán A., López R., Montoro J. B., Pou L., Estíbalez A., Pascual B., Aumente M. D., Panadero M. D., Caraballo M., Pozo J. C., Perez J. L., Falcão, A. C., Fernández de Gatta, M. M., Dominguez-Gil, A., Caramona, M. M., Lanao, J. M., Fendrich, Z., Zajic, J., Bellés Medall M. D., Casabó Alós V. G., Jiménez Torres N. V., Hervás Botella M. A., Abad Gimeno F. J., Casterá Melchor D. E., Aminian M., Mangues M. A., Clopés A., Branco C., Badell I., Pardo, N., Palací C., Bonal J., Rialp G., Bara B., Nobilis, M., Bláha, V., Havel, E., Květina, J., Brátová, M., Solichová, D., Mullerova, M., Svoboda, D., Pokrajac, M., Miljković, B., Simić, D., Brzaković, B., Galetin, A., Pinheiro, R. L., Carrondo, A. P., Sieradzki, E., Strauss, K., Olejarz, E., Marzec, A., Kaużny, J., Szymura-Oleksiak, J., Wyska, E., Jarosz, B., Kosowicz, I., Fabirkiewicz, K., Cherian, R., Vodoz, A. -L., Imsand, B., Belli, D., Rochat, Th., Müllerová, H., Falcão F., Carvalho A., Pereira T., Fonseca C., Freitas O., Resende M., Parrinha A., Costa M., Pessanha M. A., Ferreira A., Mourão L., Ceia F., Lima, Mendonça, Tavares R., SalesLuis A., Carlos Santos, Pereira, M. E. Araújo, Carmo, J. Alves do, Lacerda, J. M. Forjaz, Morais, J. A., Beaufils, C., Le Duff, M., Zamparutti, P., Assicot, P., Bohor, M., Angelini, B., Lambert, M., Manelli, J. C., Gayte-Sorbier, A., Bongrand, M. C., Timon-David, P., Fiqueira, I. C., Lourenco, R., Silva, P. A., Rodrigues, M. O., Fischer, A., Schorr, W., Radziwill, R., Lihtamo M., Jäppinen A., Tuovinen K., Pekkala M., Nuutinen L., Morató, L., Lorente, L., Muñoz, J., Monges, Ph, Blancard, A., Lacarelle, B., Denis, J. P., Bongrand, M. -C., Penot-Ragon, Ch, Gouin, F., Petitcollot, Nicole, Tinguely, I., Beney, J., Marty, S., Reymond, J. -Ph., Bussels J., Robays H., Litzinger, A., Rohda-Bohler, R., Salek, M. S., Turpin, S., Derby, E., Millar, B., Maggs, C., Santiago L. M., Batel Marques, Cajaraville, G., Tarnés, M. J., Díaz, M. J., Del Pozo, C., Plazaola, A., Vuelta, M., Díaz-Munío, E., Ferrer, A., Lozano, A., Guerra, R., Pontón, J. L., Robays, H., Kint, K., Verstraetep, A., Eini, D. El, Ojala, R. K., Kontra, K. M., Naaranlahti, T. J. P., Martorell M., Oliveras M., Juste C., Lopez M. T., Hidalgo E., Cabañas M. J., Barroso C., Llop, J. M., Rey, M., Diaz-Munio, E., Pastó, L., Tubau, M., Gómez-Bellver, M. J., Rodriguez, J., Gómez, J. M., Gónzalez, M. L., Gol V., Fuentes V., Ramón S., Girona L., Castelló T., Olona M., García L., Girón, C., Monteserín, C., Gonzalez, P., Alberola, C., Feio J. A. L., Pharm D., Batel Marques F. J., Borges Alexandrino M., Salek S., Escoms M. C., Caro I., Ticó N., Hidalgo M., Bruguera R., Jodar R., Dowell, J. M., Davey, P. G., Malek, M., Díaz-Munío, E., Vuelta, M., Pastó, L., Rev, M., Ferrer, I., Llop, J. M., Marti, T., Ibars, M., Delporte, J. P., Ansseau, M., Albert, A., Sibourg, M., Gaspard, O., Deprez, M., Ndougsa, H. M., Poma, M., Tamés, M. J., Macek K., Vlček J., Fendrich Z., Klejna M., Dhillon S., Castro I., Newton M., Zupanets, I. A., Chernyh, V. P., Bezdetko, N. B., Popov, S. B., Velieva, M. N., Babajeya, S. M., Mamedov, Y. D., Mammedov, Y. Dj., Veliev, P. M., Nasudari, A. A., Bandalieva, A. A., Nordbo, S., Smith-Solbakken, M., Myklctun, R., Berge, W., Thormodsen, M., Zupanets, L. A., Kicenko, L. S., Plusch, S. I., Isaev, S. G., Vokrouhlický, L., Souček, R., Kuneš, P., Nývlt, O., Potselueva, L. A., Egorova, S. N., Kadirova, E. A., Ziganshina, L. E., Chaloupka, J., and Genger K.

Published
1995
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33. Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes

Author

Green JB, Bethel MA, Armstrong PW, Buse JB, Engel SS, Garg J, Josse R, Kaufman KD, Koglin J, Korn S, Lachin JM, McGuire DK, Pencina MJ, Standl E, Stein PP, Suryawanshi S, Van de Werf F, Peterson ED, Holman RR, Josse RG, Califf RM, Goldstein BJ, Shapiro DR, Silverman R, Bethel A, Green J, Hayden S, Hannan K, Quintero K, Rorick T, Berdan L, Leloudis D, Califf S, Wilson M, McFarron D, Trollinger K, Pesarchick J, Eskenazi L, Campbell C, Townes O, Tolsma D, Keenan J, Milton J, Athwal R, Darbyshire J, Doran Z, Kennedy I, Gregory V, Lokhnygina Y, Prather K, Wolfley A, Usman M, Tajjar A, Gray R, Pfeffer MA, Gerstein HC, Groop L, McMurray JJ, Pocock SJ, Clayton T, Sinay I, Brieger D, Stranks S, Scheen A, Lopes R, Tankova T, Hramiak I, Grado CR, Wenying Y, Ge J, Aschner P, Skrha J, Ambos A, Strandberg T, Travert F, Hanefeld M, Riefflin A, Chan JC, Ofner P, Reddy NK, Christopher J, Mathur A, Arambam P, Mittal S, Manchanda M, Wainstein J, Ambrosio G, Pirags V, Jakuboniene N, Mohamed M, Scott R, White H, Cornel J, Halvorsen S, Tykarski A, Veresiu IA, Dreval AV, Misinkova I, Tai E, Krahulec B, Distiller L, Park Y, Rovira A, Alversson M, Chuang LM, Delibasi T, Adler A, Rodbard HW, Marre M, Goff D, Chacra A, DeVore A, Beaven A, Shah B, Hirsch B, Batch B, Bushnell C, Patel C, Melloni C, Henshaw C, Kong D, Bernecki G, Tillman H, Kang HJ, Hawes J, Strickler J, Piccini J, Wilder J, Alexander K, Mahaffey K, Patel K, Hyland K, Newby K, Jackson L, Cooper L, Armaganijan L, Szczeh L, Koshizaka M, Roe M, Morse M, Guimaraes P, Hess P, Tricoci P, Mehta R, Mathews R, Kociol R, Harrison R, Mentz R, Pokorney S, Leblanc T, Lazzarini V, Eapen Z, Truffa A, Fosbol E, Brito F, Katz M, Bahit M, Santos M, Barros P, Bernardez S, Alvarisqueta AF, Arias P, Cagide AL, Calella PR, Cantero MC, Canella JP, Cipullo MA, de Loredo L, Gelersztein ES, Gorban de Lapertosa SB, Klyver MI, Maffei LE, Maldonado N, Oviedo AI, Piskorz DL, Ridruejo MC, Saavedra SS, Sessa HA, Sinay IR, Sposetti GD, Ulla MR, Vico ML, Waitman JN, Binnekamp M, Carroll P, Cheung W, Colman P, Davis T, De Looze F, dEmden M, Fulcher G, Gerstman M, Hamilton A, Lehman S, Moses R, Proietto J, Roberts A, Shaw J, Simpson R, Sinha A, Tan Y, Topliss D, Vora P, Waites J, Crenier L, Descamps O, Keymeulen B, Mathieu C, Nobels F, Van den Bruel A, Van Gaal L, Borges JL, Costa e Forti A, Eliaschewitz FG, Felício JS, Griz LH, Hissa MN, Leite S, Panarotto D, Pimentel Filho P, Rassi N, Saraiva JK, Sgarbi JA, Silva RP, Tambascia M, Weber Silva DM, Bobeva R, Bostandzhieva R, Cinlikov I, Georgieva M, Iliev D, Ilieva E, Kovacheva S, Liubenova L, Nikitov Z, SHeinikova G, Slavcheva A, Spasova V, Temelkova-Kurktschiev T, Velichka D, Yakov A, Carpentier A, Chiasson JL, Constance C, Dumas R, Filteau P, Garceau C, Huynh T, Kaiser S, Kornder J, Leiter L, Mereu L, Miller D, Pandey S, Punthakee Z, Rabasa-Lhoret R, Robitaille Y, Saunders K, Sigal R, Sigalas J, Vizel S, Weisnagel S, Woo V, Yale JF, Yared K, Zinman B, Bunster Balocchi LB, Escobar Cerda EE, Garces Flores EE, Lanas Zanetti FT, Larrazabal Miranda Adel P, Morales Alvarado JM, Olivares Cañon CM, Potthoff Cárdenas SH, Raffo Grado CA, Rodriguez Venegas ME, Saavedra Gajardo VA, Westerberg Maldonado BH, Chen LL, Dong J, Guo X, Li QM, Shi B, Tang XL, Yang T, Yang WY, Zheng SX, Aschner Montoya P, Botero Lopez R, Coronel Arroyo JA, Cure CA, Gómez Medina AM, Molina DI, Perez Amador GA, Reyes Rincon A, Urina Triana MA, Valenzuela Rincon A, Vélez Pelaez S, Yupanqui Lozno H, Brabec T, Brychta T, Hasalova Zapletalova J, Havelkova J, Hejnicova K, Hola O, Hornackova M, Hrdina T, Kafkova D, Kellnerova I, Krystl T, Kutejova V, Mikulkova I, Nevrla J, Pantlikova C, Petr M, Racicka E, Sarbochova R, Smolenakova K, Turcinek R, Urbancova K, Vejvodova J, Vondrakova M, Zachoval R, Alt I, Kaasik Ü, Kiiroja K, Lanno R, Märtsin K, Past M, Vides H, Viitas L, Kantola I, Nieminen S, Perhonen M, Strand J, Valle T, Clergeot A, Couffinhal T, Courreges JP, Gouet D, Moulin P, Ziegler O, Badenhoop K, Behnke T, Bender G, Braun M, Dshabrailov J, Hamann A, Himpel-Boenninghoff A, Kamke W, Kasperk C, Luedemann J, Mayr P, Merkel M, Oerter EM, Ohlow MA, Ott P, Overhoff U, Paschen B, Remppis R, Rose L, Schumm-Draeger PM, Segiet T, Strotmann HJ, Stuchlik G, Stürmer W, Thinesse-Mallwitz M, Tytko A, Wendisch U, Wurziger J, Ho AY, Kam G, Kong AP, Lam YY, Lau EY, Lee S, Siu SC, Tomlinson B, Tsang CC, Yeung VT, Dezső E, Dudás M, Földesi I, Fülöp T, Késmárki N, Koranyi L, Nagy K, Oroszlán T, Pécsvárady Z, Ples Z, Taller A, Agarwal P, Ambulkar S, Aravind S, Balaji V, Kalra S, Kesavadev J, Kudalkar H, Kumar A, Misra A, Mithal A, Mohan V, Pitale S, Ramu M, Reddy N, Shah S, Shamanna P, Sharda A, Sharma A, Shunmugavelu M, Srikanta S, Suryaprakash G, Abramov G, Adawi F, Bashkin A, Darawsha M, Fuchs S, Harman-Boehm I, Hayek T, Jaffe A, Knobler H, Minuchin O, Mosseri M, Shechter M, Shimon I, Stern N, Tsur A, Vishlitzky V, Alfonsi F, Cavalot F, Del Vecchio L, Frisinghelli A, Gambardella S, Lauro D, Lembo G, Leotta S, Mondillo S, Novo S, Pedrinelli R, Piatti P, Salvioni A, Tritto I, Zavaroni DZ, Ahn KJ, Choi KM, Chung C, Han SJ, Kim DM, Kim IJ, Kim MH, Lee IK, Nam M, Park IeB, Park KS, Park TS, Rhee EJ, Yoo SJ, Andersone I, Balode A, Eglite R, Gersamija A, Kakurina N, Jegere B, Leitane I, Pastare S, Stalte V, Teterovska D, Baltramonaitiene K, Barsiene L, Ceponis J, Lasiene J, Levinger A, Sirutaviciene A, Sulskiene M, Urbanaviciene L, Valius L, Varanauskiene E, Velickiene D, Mahendran KA, Abu Hassan MR, Aziz NA, Hussein Z, Ismail IS, Kamaruddin NA, Nordin Z, Nayar SK, Ramanathan GR, Sothiratnam R, Beijerbacht H, Breedveld R, Cornel JH, Den Hartog F, Hermans W, Kietselaer B, Kooy A, Lenderink T, Nierop P, Remmen J, Rojas Lingan G, Ronner E, Van der Heijden R, Van Hessen M, van Kempen W, Voors-Pette C, Westendorp I, Baker J, Benatar J, Cutfield R, Krebs J, Leikis R, Lunt H, Manning P, Williams M, Birkeland K, Claudi T, Istad H, Karlsson T, Ossum Gronert J, Arciszewska M, Artemiuk E, Blach E, Blicharski T, Cypryk K, Dabrowska M, Górny G, Górska M, Jakubowska I, Jazwinska-Tarnawska E, Karczmarczyk A, Kitowska-Koterla J, Koltowski L, Krzyzagorska E, Pasternak D, Pentela-Nowicka J, Piesiewicz W, Przekwas-Jaruchowska M, Rajzer M, Salamon-Ferenc A, Sawicki A, Skowron T, Śmiałowski A, Albota A, Alexandru C, Crisan C, Dumitrescu A, Ferariu IE, Lupusoru DA, Munteanu M, Negru D, Nicolau A, Pintiliei E, Popescu A, Serban G, Voitec M, Babenko A, Barbarash O, Bondar I, Chizhov P, Demin A, Dora S, Dreval A, Ershova O, Gratsiansky N, Ketova G, Kotelnikov M, Levashov S, Morugova T, Mustafina S, Pekarskiy S, Raskina T, Rechkova E, Samoylova Y, Sazonova O, Sherenkov A, Shilkina N, Stetsyuk O, Tretyakova T, Turova E, Valeeva F, Zadionchenko V, Dalan R, Tan RS, Tay L, Buganova I, Fabry J, Jan C, Toserova E, Zak R, Zimanova J, Badat A, Bester F, Burgess L, De Jong D, Ellis G, Fouche L, Govender P, Govind U, Naidoo V, Nieuwoudt G, Nortje H, Rheeder P, Robertson L, Siddique N, Stapelberg AM, Trinder Y, Van Der Merwe A, Van Zyl L, Viljoen M, Wilhase A, Botella M, Civeira Murillo F, de Teresa L, Del Cañizo FJ, Extremera BG, Gimeno EJ, Martin-Hidalgo A, Morales C, Nubiola A, Tinahones Madueño F, Tranche S, Trescolí Serrano C, Alvarsson M, Eizyk E, Gillblad A, Johansson P, Löndahl M, Ohlsson-Önerud Å, Rautio A, Sundström U, Torstensson I, Chen JF, Chou CW, Ho LT, Hsieh IC, Huang BH, Huang CL, Huang CN, Lai WT, Lo PH, Pei D, Sheu WH, Wang SY, Araz M, Bakiner O, Comlekci A, Guler S, Sahin I, Sarac F, Tarkun I, Ukinc K, Yilmaz M, Abdulhakim E, Abraham P, Adamson K, Blagden M, Bundy C, Daly M, Davies M, Deshpande M, Gillings S, Harvey P, Horvathova V, Hristova D, Jaap A, Johnson A, Jones H, Kerrane J, Kilvert A, Ko T, Kumar J, Lindsay R, Litchfield J, McCrimmon R, McKnight J, Millward B, Oyesile B, Purewal T, Ravikumar C, Robinson A, Sathyapalan T, Simpson H, Thomas H, Turner W, Weaver J, Wilding J, Wiles P, Adkins K, Akpunonu B, Albu J, Anagnostis G, Anastasi L, Argoud G, Aroda V, Azizad M, Banerji MA, Bartkowiak A Jr, Bays H, Behn P, Bergenstal R, Bhargava A, Bias D, Bolster E, Buchanan P, Busch R, Chadha C, Chang M, Cheng C, Cohen A, Cohen J, Cole B, Connery L, Cooperman M, Cushman W, DAgostino R, Dayamani P, De Lemos J, De Meireles M, Dean J, DeHart D, Detweiler R, Donovan D, Dugano-Daphnis P, Dulin M, Dunn F, Eaton C, Erickson B, Estevez R, Feinglos M, Fonseca V, Force R, Forker A, Fox D, Gabriel J, Garcia R, Garvey T, Gaudiani L, Getaneh A, Goldberg A, Goldman S, Hairston K, Harris R, Haught W, Hidalgo H Jr, Higgins A, Houchin V, Ison R, Jacobs G, Jaffrani N, Jafry B, Kapsner P, Kaye W, Labroo A, Levinson L, Lewis S, Lillestol M, Luttrell L, Madu I, McNeill R, Merrick B, Metzger F, Nadar V, Nagelberg S, Nash S, Oparil S, Osei K, Papademetriou V, Patel N, Pedley C, Prentiss A, Radbill M, Raisinghani A, Rassouli N, Reddy R, Rees P, Rendell M, Robbins D, Rodbard H, Rohlf J, Roseman H, Rudolph L, Sadler L, Schnall A, Schramm R, Schubart U, Seneviratne T, Shanik M, Snyder H, Sorli C, Stich M, Sweeney ME, Tsao J, Ukwade P, Viswanath D, Vo A, Vogel C, Voyce S, Weintraub H, White J, Wood M, Wu P, Wysham C, Zimmerman R, Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, and Green JB, Bethel MA, Armstrong PW, Buse JB, Engel SS, Garg J, Josse R, Kaufman KD, Koglin J, Korn S, Lachin JM, McGuire DK, Pencina MJ, Standl E, Stein PP, Suryawanshi S, Van de Werf F, Peterson ED, Holman RR, Holman RR, Peterson ED, Holman RR, Peterson ED, Armstrong PW, Buse JB, Josse RG, Kaufman KD, Koglin J, Korn S, Lachin JM, McGuire DK, Standl E, Stein PP, Suryawanshi S, Van de Werf F, Engel SS, Califf RM, Goldstein BJ, Shapiro DR, Silverman R, Bethel A, Green J, Hayden S, Hannan K, Quintero K, Rorick T, Berdan L, Leloudis D, Califf S, Wilson M, McFarron D, Trollinger K, Pesarchick J, Eskenazi L, Campbell C, Townes O, Tolsma D, Keenan J, Milton J, Athwal R, Darbyshire J, Doran Z, Kennedy I, Gregory V, Garg J, Lokhnygina Y, Prather K, Wolfley A, Usman M, Tajjar A, Gray R, Pfeffer MA, Gerstein HC, Groop L, McMurray JJ, Pocock SJ, Clayton T, Sinay I, Brieger D, Stranks S, Scheen A, Lopes R, Tankova T, Hramiak I, Grado CR, Wenying Y, Ge J, Aschner P, Skrha J, Ambos A, Strandberg T, Travert F, Hanefeld M, Riefflin A, Chan JC, Ofner P, Reddy NK, Christopher J, Mathur A, Arambam P, Mittal S, Manchanda M, Wainstein J, Ambrosio G, Pirags V, Jakuboniene N, Mohamed M, Scott R, White H, Cornel J, Halvorsen S, Tykarski A, Veresiu IA, Dreval AV, Misinkova I, Tai E, Krahulec B, Distiller L, Park Y, Rovira A, Alversson M, Chuang LM, Delibasi T, Adler A, Rodbard HW, Marre M, Goff D, Chacra A, DeVore A, Beaven A, Shah B, Hirsch B, Batch B, Bushnell C, Patel C, Melloni C, Henshaw C, Kong D, McFarron D, Bernecki G, Tillman H, Kang HJ, Green J, Hawes J, Strickler J, Piccini J, Wilder J, Alexander K, Mahaffey K, Patel K, Hyland K, Newby K, Jackson L, Cooper L, Armaganijan L, Szczeh L, Koshizaka M, Roe M, Morse M, Guimaraes P, Hess P, Tricoci P, Mehta R, Lopes R, Mathews R, Kociol R, Harrison R, Mentz R, Pokorney S, Leblanc T, Lazzarini V, Eapen Z, Truffa A, Fosbol E, Brito F, Katz M, Bahit M, Santos M, Barros P, Bernardez S, Alvarisqueta AF, Arias P, Cagide AL, Calella PR, Cantero MC, Canella JP, Cipullo MA, de Loredo L, Gelersztein ES, Gorban de Lapertosa SB, Klyver MI, Maffei LE, Maldonado N, Oviedo AI, Piskorz DL, Ridruejo MC, Saavedra SS, Sessa HA, Sinay IR, Sposetti GD, Ulla MR, Vico ML, Waitman JN, Binnekamp M, Carroll P, Cheung W, Colman P, Davis T, De Looze F, dEmden M, Fulcher G, Gerstman M, Hamilton A, Lehman S, Moses R, Proietto J, Roberts A, Shaw J, Simpson R, Sinha A, Stranks S, Tan Y, Topliss D, Vora P, Waites J, Crenier L, Descamps O, Keymeulen B, Mathieu C, Nobels F, Scheen A, Van den Bruel A, Van Gaal L, Borges JL, Costa e Forti A, Eliaschewitz FG, Felício JS, Griz LH, Hissa MN, Leite S, Panarotto D, Pimentel Filho P, Rassi N, Saraiva JK, Sgarbi JA, Silva RP, Tambascia M, Weber Silva DM, Bobeva R, Bostandzhieva R, Cinlikov I, Georgieva M, Iliev D, Ilieva E, Kovacheva S, Liubenova L, Nikitov Z, SHeinikova G, Slavcheva A, Spasova V, Tankova T, Temelkova-Kurktschiev T, Velichka D, Yakov A, Carpentier A, Chiasson JL, Constance C, Dumas R, Filteau P, Garceau C, Hramiak I, Huynh T, Kaiser S, Kornder J, Leiter L, Mereu L, Miller D, Pandey S, Punthakee Z, Rabasa-Lhoret R, Robitaille Y, Saunders K, Sigal R, Sigalas J, Vizel S, Weisnagel S, Woo V, Yale JF, Yared K, Zinman B, Bunster Balocchi LB, Escobar Cerda EE, Garces Flores EE, Lanas Zanetti FT, Larrazabal Miranda Adel P, Morales Alvarado JM, Olivares Cañon CM, Potthoff Cárdenas SH, Raffo Grado CA, Rodriguez Venegas ME, Saavedra Gajardo VA, Westerberg Maldonado BH, Chen LL, Dong J, Guo X, Li QM, Shi B, Tang XL, Yang T, Yang WY, Zheng SX, Aschner Montoya P, Botero Lopez R, Coronel Arroyo JA, Cure CA, Gómez Medina AM, Molina DI, Perez Amador GA, Reyes Rincon A, Urina Triana MA, Valenzuela Rincon A, Vélez Pelaez S, Yupanqui Lozno H, Brabec T, Brychta T, Hasalova Zapletalova J, Havelkova J, Hejnicova K, Hola O, Hornackova M, Hrdina T, Kafkova D, Kellnerova I, Krystl T, Kutejova V, Mikulkova I, Nevrla J, Pantlikova C, Petr M, Racicka E, Sarbochova R, Skrha J, Smolenakova K, Turcinek R, Urbancova K, Vejvodova J, Vondrakova M, Zachoval R, Alt I, Ambos A, Kaasik Ü, Kiiroja K, Lanno R, Märtsin K, Past M, Vides H, Viitas L, Kantola I, Nieminen S, Perhonen M, Strand J, Strandberg T, Valle T, Clergeot A, Couffinhal T, Courreges JP, Gouet D, Moulin P, Travert F, Ziegler O, Badenhoop K, Behnke T, Bender G, Braun M, Dshabrailov J, Hamann A, Hanefeld M, Himpel-Boenninghoff A, Kamke W, Kasperk C, Luedemann J, Mayr P, Merkel M, Oerter EM, Ohlow MA, Ott P, Overhoff U, Paschen B, Remppis R, Riefflin A, Rose L, Schumm-Draeger PM, Segiet T, Strotmann HJ, Stuchlik G, Stürmer W, Thinesse-Mallwitz M, Tytko A, Wendisch U, Wurziger J, Ho AY, Kam G, Kong AP, Lam YY, Lau EY, Lee S, Siu SC, Tomlinson B, Tsang CC, Yeung VT, Dezső E, Dudás M, Földesi I, Fülöp T, Késmárki N, Koranyi L, Nagy K, Ofner P, Oroszlán T, Pécsvárady Z, Ples Z, Taller A, Agarwal P, Ambulkar S, Aravind S, Balaji V, Christopher J, Kalra S, Kesavadev J, Kudalkar H, Kumar A, Misra A, Mithal A, Mohan V, Pitale S, Ramu M, Reddy N, Shah S, Shamanna P, Sharda A, Sharma A, Shunmugavelu M, Srikanta S, Suryaprakash G, Abramov G, Adawi F, Bashkin A, Darawsha M, Fuchs S, Harman-Boehm I, Hayek T, Jaffe A, Knobler H, Minuchin O, Mosseri M, Shechter M, Shimon I, Stern N, Tsur A, Vishlitzky V, Wainstein J, Alfonsi F, Cavalot F, Del Vecchio L, Frisinghelli A, Gambardella S, Lauro D, Lembo G, Leotta S, Mondillo S, Novo S, Pedrinelli R, Piatti P, Salvioni A, Tritto I, Zavaroni DZ, Ahn KJ, Choi KM, Chung C, Han SJ, Kim DM, Kim IJ, Kim MH, Lee IK, Nam M, Park IeB, Park KS, Park TS, Park Y, Rhee EJ, Yoo SJ, Andersone I, Balode A, Eglite R, Gersamija A, Kakurina N, Jegere B, Leitane I, Pastare S, Pirags V, Stalte V, Teterovska D, Baltramonaitiene K, Barsiene L, Ceponis J, Jakuboniene N, Lasiene J, Levinger A, Sirutaviciene A, Sulskiene M, Urbanaviciene L, Valius L, Varanauskiene E, Velickiene D, Mahendran KA, Abu Hassan MR, Aziz NA, Hussein Z, Ismail IS, Kamaruddin NA, Mohamed M, Nordin Z, Nayar SK, Ramanathan GR, Sothiratnam R, Beijerbacht H, Breedveld R, Cornel JH, Den Hartog F, Hermans W, Kietselaer B, Kooy A, Lenderink T, Nierop P, Remmen J, Rojas Lingan G, Ronner E, Van der Heijden R, Van Hessen M, van Kempen W, Voors-Pette C, Westendorp I, Baker J, Benatar J, Cutfield R, Krebs J, Leikis R, Lunt H, Manning P, Scott R, Williams M, Birkeland K, Claudi T, Halvorsen S, Istad H, Karlsson T, Ossum Gronert J, Arciszewska M, Artemiuk E, Blach E, Blicharski T, Cypryk K, Dabrowska M, Górny G, Górska M, Jakubowska I, Jazwinska-Tarnawska E, Karczmarczyk A, Kitowska-Koterla J, Koltowski L, Krzyzagorska E, Pasternak D, Pentela-Nowicka J, Piesiewicz W, Przekwas-Jaruchowska M, Rajzer M, Salamon-Ferenc A, Sawicki A, Skowron T, Śmiałowski A, Tykarski A, Albota A, Alexandru C, Crisan C, Dumitrescu A, Ferariu IE, Lupusoru DA, Munteanu M, Negru D, Nicolau A, Pintiliei E, Popescu A, Serban G, Veresiu IA, Voitec M, Babenko A, Barbarash O, Bondar I, Chizhov P, Demin A, Dora S, Dreval A, Ershova O, Gratsiansky N, Ketova G, Kotelnikov M, Levashov S, Morugova T, Mustafina S, Pekarskiy S, Raskina T, Rechkova E, Samoylova Y, Sazonova O, Sherenkov A, Shilkina N, Stetsyuk O, Tretyakova T, Turova E, Valeeva F, Zadionchenko V, Dalan R, Tan RS, Tay L, Buganova I, Fabry J, Jan C, Krahulec B, Toserova E, Zak R, Zimanova J, Badat A, Bester F, Burgess L, De Jong D, Distiller L, Ellis G, Fouche L, Govender P, Govind U, Naidoo V, Nieuwoudt G, Nortje H, Rheeder P, Robertson L, Siddique N, Stapelberg AM, Trinder Y, Van Der Merwe A, Van Zyl L, Viljoen M, Wilhase A, Botella M, Civeira Murillo F, de Teresa L, Del Cañizo FJ, Extremera BG, Gimeno EJ, Martin-Hidalgo A, Morales C, Nubiola A, Rovira A, Tinahones Madueño F, Tranche S, Trescolí Serrano C, Alvarsson M, Eizyk E, Gillblad A, Johansson P, Löndahl M, Ohlsson-Önerud Å, Rautio A, Sundström U, Torstensson I, Chen JF, Chou CW, Chuang LM, Ho LT, Hsieh IC, Huang BH, Huang CL, Huang CN, Lai WT, Lo PH, Pei D, Sheu WH, Wang SY, Araz M, Bakiner O, Comlekci A, Delibasi T, Guler S, Sahin I, Sarac F, Tarkun I, Ukinc K, Yilmaz M, Abdulhakim E, Abraham P, Adamson K, Adler A, Blagden M, Bundy C, Daly M, Davies M, Deshpande M, Gillings S, Harvey P, Horvathova V, Horvathova V, Hristova D, Jaap A, Johnson A, Jones H, Kerrane J, Kilvert A, Ko T, Kumar J, Lindsay R, Litchfield J, McCrimmon R, McKnight J, Millward B, Oyesile B, Purewal T, Ravikumar C, Robinson A, Sathyapalan T, Simpson H, Thomas H, Turner W, Weaver J, Wilding J, Wiles P, Adkins K, Akpunonu B, Albu J, Anagnostis G, Anastasi L, Argoud G, Aroda V, Azizad M, Banerji MA, Bartkowiak A Jr, Bays H, Behn P, Bergenstal R, Bhargava A, Bias D, Bolster E, Buchanan P, Busch R, Chadha C, Chang M, Cheng C, Cohen A, Cohen J, Cole B, Connery L, Cooperman M, Cushman W, DAgostino R, Davies M, Dayamani P, De Lemos J, De Meireles M, Dean J, DeHart D, Detweiler R, Donovan D, Dugano-Daphnis P, Dulin M, Dunn F, Eaton C, Erickson B, Estevez R, Feinglos M, Fonseca V, Force R, Forker A, Fox D, Gabriel J, Garcia R, Garvey T, Gaudiani L, Getaneh A, Goff D, Goldberg A, Goldman S, Hairston K, Harris R, Haught W, Hidalgo H Jr, Higgins A, Houchin V, Ison R, Jacobs G, Jaffrani N, Jafry B, Kapsner P, Kaye W, Labroo A, Levinson L, Lewis S, Lillestol M, Luttrell L, Madu I, McNeill R, Merrick B, Metzger F, Nadar V, Nagelberg S, Nash S, Oparil S, Osei K, Papademetriou V, Patel N, Pedley C, Prentiss A, Radbill M, Raisinghani A, Rassouli N, Reddy R, Rees P, Rendell M, Robbins D, Rodbard H, Rohlf J, Roseman H, Rudolph L, Sadler L, Schnall A, Schramm R, Schubart U, Seneviratne T, Shanik M, Snyder H, Sorli C, Stich M, Sweeney ME, Tsao J, Ukwade P, Viswanath D, Vo A, Vogel C, Voyce S, Weintraub H, White J, Wood M, Wu P, Wysham C, Zimmerman R

Subjects
Oral, medicine.medical_specialty, Heart diseases, Glycosylated, Administration, Oral, heart failure, Type 2 diabetes, Dipeptidyl peptidase-4 inhibitor, Kaplan-Meier Estimate, Placebo, Sitagliptin Phosphate, Sitagliptin, Cardiovascular Outcomes, chemistry.chemical_compound, Drug Therapy, Double-Blind Method, Internal medicine, Diabetes Mellitus, medicine, Humans, Hypoglycemic Agents, Glycated Hemoglobin, Hemoglobin A, Glycosylated, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Drug Therapy, Combination, Follow-Up Studies, Heart Diseases, Heart Failure, Hospitalization, Pyrazines, Triazoles, Medicine (all), business.industry, Semaglutide, Hemoglobin A, General Medicine, ta3121, medicine.disease, Surgery, Cardiovascular diseases, chemistry, Sitagliptin, Administration, Combination, Glycated hemoglobin, business, Type 2, Alogliptin, medicine.drug
Abstract

BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to-0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P

Published
2015

35. Abstracts of papers and posters safe handling of medicines

Author

Meyer, H. -J., Tromp, Th(Dick) F. J., van der Kleijn, E., Fields, Suzanne M., Moors, J. P. P., Enlund, H., Luscombe, D. K., Remond, J -Ph, Martv, S., Dhillon, S., Taylor, D., Kostrzewski, A., Bluml, B. M., Enlow, M. L., Metzler, S. E., de Vries, Philip A., Duty, C. J., Lee, H. Y., Ábrahám, Tibor, Cardoni, A. A., Sýkora, J., Szücsová, S., Reymond, J. -Ph, Marty, S, Engová, D., Sheridan, J., Vlček, J., Webb, D. G., Bates, I. P., Tabachnik A., Cass Y., Jacobs J., Vexler A., Gorodetsky, R., Whittlesea, C. M. C., Walker, R., Khan, F., Houghton, J., Phillips, I., Szymura-Oleksiak, J., Wasieczko, A., Wyska, E., Ayani, I., Errecalde, M. F., Rodriauez-Sasiain, J. M., Aouirre, C., Bellés Medall M. D., Casabó Alos V. G., Hervás Botella M. A., Cabrera Pérez A., Jiménez Torres N. V., Casterá Melchor D. E., Abad Gimeno F. J., Clark, J. E., Gomez, E. C., Cruz, A. C., Wilbur, R. L., Alfonso, I., Grout, C. H., Goldstein, R., Rivers, P., Stutz, K., Mühlcbach, S., Udeani, George, Zervopoulous, Irene, Patel, Krishna, Mullane, Michael, Radziwill, R., Dudek, J., Herbst, U., Bency, J., Muff, P., Marty, S., Rcymond, J. -Ph, Aumente M. D., Panadero M. D., Latre J. M., Torres M., Villegas M. J., Alvarez J., van Dijk, E. A., Logman, E. M., Ploeger, B., van der Schors, T. G., Steensma, D. J., Langlois-Karaga, A., Davignon, A., Bues-Charbit, M., Somme, V., Albanese, J., Durbec, O., Martin, C., Morati, N., Balansard, G., Pereira, M. E. Araújo, Nogueira, A., Silva, J. C., Mega, I., Costa, A. Gomes, Morais, J. A., Prata, M. M., Cajaraville, G., Tamés, M. J., García, B., Batel Marqucs F. J., Capela H. S., Pomingues P., Feio J. A., Siha C., Wolter, K., Fritschka, E., Schneesann, H., Stuurman, A., Gudjonsdottir, A., Angelo, H. R., Rasmuassen, M., Rasmussen, S. N., Carrera, J., Idoate, A., Modrego, A., Tejedor, I., Giráldez, J., Mangues, M. A., Farré, R., Demestre, X., Ginovart, G., Orozco, J., Julio, G., Moral, M. A., Busin, C., Bardin, C., Seroux, C., Sauvageon-Martre, H., Sraer, J. -D., Chast, F., Real, J. V., Climente, M., Font, I., Pérez, C., Ordovás, J. P., Hermenegildo, M., Catalán, J. L., Juan, J., Jiménez, N. V., Amiot, F., Clavel, S., Sarrut, B., Doreau, C., Hips, F. Zs, Soós, Gy, Petô-Nagy, G., Vincze, Z., Robays H., Freidank, A., Fischer, A., Cordovilla, H., Font, B., Ortega, A., Salek, M. S., Thomas, S., Baver, A. J., Vandenbroucke J., Ekedahl, A., Tuovinen K., Wallenius K., Enlund H., Boeke, A. W., Veenstra, E. J., van de Poll, M. A. P. C., Nonkes, K., Carlen, I., Tanner, M., Reinke, C., Escher, J., Fischer, J., Marly, S., Ooi, G. K., Cottle, A., Savage, A., Temesvári, E., Montero, M. C., Pastor, M., Valdivia, M. L., Buenestado, C., Lluch, A., Atienza, M., Santos, B., Echeverria Roca M., Fernandez Gallastegui S., Alonso Rizaldos C., Arce Trueba M. D., Booth, C. D., Aldaz, A., Lacasa, C., Cordovilla, M., Alzina, V., Sheridan, J. L., Webb, D. G., Usselmann, B., Carstens, G., Falcao, A. C., Femández de Gatta, M. M., Cobo, F. Nieto, Gorzátez, A. C. Alonso, Lanao, J. M., Dominguez -Gil, A., Burr, A., Ferreira, M. P., Rodrigues, M. O., Pereira, M. E., Marques, M. F., Vicente, M. C., Carrondo, A. P., Pires, M. A., Granja, M. A., Tuneu L., Serna J., Saló E., Cerutti P., Cardona P., Bonal J., Cosh, D. G., Abbott, F., Alderman, C. P., Mav, F. W., Peters, P. G., Scott, S. D., Jenkins, D., Cairns, C., Barber, N. D., Cammie, S. M., Burr, A. J., Brännström, I., Boya, P. Giner, Aliaga, C. Parreño, González, M. M. Negredo, Mansilla, L. Lorente, Pidrman, V., Fendrich, Z., Alberola, C., Castillo, B., Girón, C., Morell, A., López-Calull C., Carcia-Capdevila L., Sanz M., Cardona D., Castro I., Farré R., Saura R., Pérez J. M., Johnsen, Eva, Krogsgård, Ole, Pinheiro, R. L., Morais, I. A., Batel Marques F. J., Domingues P., Feio J. A., Silva C., Astdrager, C. L. L., Schnlekamp, T., de Gier, J. J., Rutten, C. W. H., Rivera, M. C., Vilanova, M., Mattei, I., Roglan, A., Serna, J., and Bonal, J.

Published
1993
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36. First report of Tomato leaf curl New Delhi virus infecting cucurbits in the Canary Islands

Author

Universitat Politècnica de València. Departamento de Ecosistemas Agroforestales - Departament d'Ecosistemes Agroforestals, Universitat Politècnica de València. Instituto Agroforestal Mediterráneo - Institut Agroforestal Mediterrani, Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia, European Regional Development Fund, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, ESPINO, ANA, Botella, M., Otazo-González, H.C., Alfaro Fernández, Ana Olvido, Font San Ambrosio, Maria Isabel, Galipienso-Torregrosa, Luis, Rubio MIgélez, Luis, Universitat Politècnica de València. Departamento de Ecosistemas Agroforestales - Departament d'Ecosistemes Agroforestals, Universitat Politècnica de València. Instituto Agroforestal Mediterráneo - Institut Agroforestal Mediterrani, Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia, European Regional Development Fund, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, ESPINO, ANA, Botella, M., Otazo-González, H.C., Alfaro Fernández, Ana Olvido, Font San Ambrosio, Maria Isabel, Galipienso-Torregrosa, Luis, and Rubio MIgélez, Luis

Published
2019

43. Swarm hybrid optimization for a piecewise model fitting applied to a glucose model

Author

Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, Acedo Rodríguez, Luis, Botella, M., Cortés, J.-C., Hidalgo, J.I., Maqueda, E., Villanueva Micó, Rafael Jacinto, Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, Acedo Rodríguez, Luis, Botella, M., Cortés, J.-C., Hidalgo, J.I., Maqueda, E., and Villanueva Micó, Rafael Jacinto

Abstract

[EN] Purpose ¿ The purpose of this paper is to study insulin pump therapy and accurate monitoring of glucose levels in diabetic patients, which are current research trends in diabetology. Both problems have a wide margin for improvement and promising applications in the control of parameters and levels involved. Design/methodology/approach ¿ The authors have registered data for the levels of glucose in diabetic patients throughout a day with a temporal resolution of 5 minutes, the amount and time of insulin administered and time of ingestion. The estimated quantity of carbohydrates is also monitored. A mathematical model for Type 1 patients was fitted piecewise to these data and the evolution of the parameters was analyzed. Findings ¿ They have found that the parameters for the model change abruptly throughout a day for the same patient, but this set of parameters account with precision for the evolution of the glucose levels in the test patients. This fitting technique could be used to personalize treatments for specific patients and predict the glucose-level variations in terms of hours or even shorter periods of time. This way more effective insulin pump therapies could be developed. Originality/value ¿ The proposed model could allow for the development of improved schedules on insulin pump therapies

Published
2018

44. Avances en la detección de southern tomato virus (STV) en distintas especies vegetales y efecto de su coinfección con pepino mosaic virus (pepMV) en tomate

Author

Alfaro-Fernández, Ana, Sanahuja, E., Blanco, L., Bosch, R., Elvira-González, Laura, Rubio, Luis, Estévez-Caparrós, J. M., Muñoz-Yerbes, M. J., Espino, A., Botella, M., Benito, P., Monagas, J. J., Serra, J., Roselló, Josep, Hernández, Desamparados, Guerri, José, Cano-García, A. M., Reyes-Betancort, J. A., Galipienso, Luis, and Font-San-Ambrosio, Isabel

Subjects
H20 Plant diseases, Southern tomato virus, Virus del mosaico del pepino verde
Published
2017

45. Arabidopsis K+ transporter HAK5-mediated high-affinity root K+ uptake is regulated by protein kinases CIPK1 and CIPK9.

Author

Lara, Alberto, Ródenas, Reyes, Andrés, Zaida, Martínez, Vicente, Quintero, Francisco J, Nieves-Cordones, Manuel, Botella, M Angeles, and Rubio, Francisco

Subjects
PROTEIN kinases, ARABIDOPSIS, ARABIDOPSIS proteins, ORGANIC cation transporters, PLANT growth
Abstract

The high-affinity K+ transporter HAK5 is the major contributor to root K+ uptake from dilute solutions in K+-starved Arabidopsis plants. Its functionality is tightly regulated and its activity is enhanced under K+ starvation by the transcriptional induction of the AtHAK5 gene, and by the activation of the transporter via the AtCBL1–AtCIPK23 complex. In the present study, the 26 members of the Arabidopsis CIPK protein kinase family were screened in yeast for their capacity to activate HAK5-mediated K+ uptake. Among them, AtCIPK1 was the most efficient activator of AtHAK5. In addition, AtCIPK9, previously reported to participate in K+ homeostasis, also activated the transporter. In roots, the genes encoding AtCIPK1 and AtCIPK9 were induced by K+ deprivation and atcipk1 and atcipk9 Arabidopsis KO mutants showed a reduced AtHAK5-mediated Rb+ uptake. Activation of AtHAK5 by AtCIPK1 did not occur under hyperosmotic stress conditions, where AtCIPK1 function has been shown to be required to maintain plant growth. Taken together, our data contribute to the identification of the complex regulatory networks that control the high-affinity K+ transporter AtHAK5 and root K+ uptake. [ABSTRACT FROM AUTHOR]

Published
2020
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46. Root high‐affinity K+ and Cs+ uptake and plant fertility in tomato plants are dependent on the activity of the high‐affinity K+ transporter SlHAK5.

Author

Nieves‐Cordones, Manuel, Lara, Alberto, Silva, Martha, Amo, Jesús, Rodriguez‐Sepulveda, Pascual, Rivero, Rosa M., Martínez, Vicente, Botella, M. Angeles, and Rubio, Francisco

Subjects
PLANT fertility, TOMATOES, PLANT growth, PLANT development, POLLEN viability, REVERSE genetics, PLANT defenses, CROP growth
Abstract

Root K+ acquisition is a key process for plant growth and development, extensively studied in the model plant Arabidopsis thaliana. Because important differences may exist among species, translational research supported by specific studies is needed in crops such as tomato. Here we present a reverse genetics study to demonstrate the role of the SlHAK5 K+ transporter in tomato K+ nutrition, Cs+ accumulation and its fertility. slhak5 KO lines, generated by CRISPR‐Cas edition, were characterized in growth experiments, Rb+ and Cs+ uptake tests and root cells K+‐induced plasma membrane depolarizations. Pollen viability and its K+ accumulation capacity were estimated by using the K+‐sensitive dye Ion Potassium Green 4. SlHAK5 is the major system for high‐affinity root K+ uptake required for plant growth at low K+, even in the presence of salinity. It also constitutes a pathway for Cs+ entry in tomato plants with a strong impact on fruit Cs+ accumulation. SlHAK5 also contributes to pollen K+ uptake and viability and its absence produces almost seedless fruits. Knowledge gained into SlHAK5 can serve as a model for other crops with fleshy fruits and it can help to generate tools to develop low Cs+ or seedless fruits crops. The K+ transporter SlHAK5 from tomato plays a crucial role in K+ nutrition, in particular under saline conditions, and in the accumulation of Cs+ in vegetative tissues and in fruits. Moreover, slhak5 fruits have few seeds which are related to SlHAK5 contribution to pollen K+ uptake and viability. [ABSTRACT FROM AUTHOR]

Published
2020
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47. A genetic algorithm approach to customizing a glucose model based on usual therapeutic parameters

Author

Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, Ministerio de Economía y Competitividad, Cervigón, Carlos, Hidalgo, J.I., Botella, M., Villanueva Micó, Rafael Jacinto, Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, Ministerio de Economía y Competitividad, Cervigón, Carlos, Hidalgo, J.I., Botella, M., and Villanueva Micó, Rafael Jacinto

Abstract

[EN] Type 1 diabetes mellitus is a chronic disease characterized by the increase of glucose in the blood due to a defect in the action or in the production of insulin. For completely autonomous glycemic regulation, a model would be required which permits the future evolution of blood glucose to be estimated. One of the main problems in identifying models is the high variability of glucose profiles both from one patient to another, and in the same patient under not very different conditions. In this paper, we propose a method using an evolutionary algorithm to define the values of the parameters of a minimal model based on standard clinical therapy for a several-day horizon. The algorithm is able to show the trend of blood glucose in a 5-day profile by adjusting the glucose model.

Published
2017

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