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1. Coherent soft X-ray pulses from an echo-enabled harmonic generation free-electron laser

Author

Rebernik Ribič, P, Abrami, A, Badano, L, Bossi, M, Braun, HH, Bruchon, N, Capotondi, F, Castronovo, D, Cautero, M, Cinquegrana, P, Coreno, M, Couprie, ME, Cudin, I, Boyanov Danailov, M, De Ninno, G, Demidovich, A, Di Mitri, S, Diviacco, B, Fawley, WM, Feng, C, Ferianis, M, Ferrari, E, Foglia, L, Frassetto, F, Gaio, G, Garzella, D, Ghaith, A, Giacuzzo, F, Giannessi, L, Grattoni, V, Grulja, S, Hemsing, E, Iazzourene, F, Kurdi, G, Lonza, M, Mahne, N, Malvestuto, M, Manfredda, M, Masciovecchio, C, Miotti, P, Mirian, NS, Petrov Nikolov, I, Penco, GM, Penn, G, Poletto, L, Pop, M, Prat, E, Principi, E, Raimondi, L, Reiche, S, Roussel, E, Sauro, R, Scafuri, C, Sigalotti, P, Spampinati, S, Spezzani, C, Sturari, L, Svandrlik, M, Tanikawa, T, Trovó, M, Veronese, M, Vivoda, D, Xiang, D, Zaccaria, M, Zangrando, D, Zangrando, M, and Allaria, EM

Subjects
Physical Sciences, Mathematical Sciences, Optoelectronics & Photonics
Abstract

X-ray free-electron lasers (FELs), which amplify light emitted by a relativistic electron beam, are extending nonlinear optical techniques to shorter wavelengths, adding element specificity by exciting and probing electronic transitions from core levels. These techniques would benefit tremendously from having a stable FEL source, generating spectrally pure and wavelength-tunable pulses. We show that such requirements can be met by operating the FEL in the so-called echo-enabled harmonic generation (EEHG) configuration. Here, two external conventional lasers are used to precisely tailor the longitudinal phase space of the electron beam before emission of X-rays. We demonstrate high-gain EEHG lasing producing stable, intense, nearly fully coherent pulses at wavelengths as short as 5.9 nm (~211 eV) at the FERMI FEL user facility. Low sensitivity to electron-beam imperfections and observation of stable, narrow-band, coherent emission down to 2.6 nm (~474 eV) make the technique a prime candidate for generating laser-like pulses in the X-ray spectral region, opening the door to multidimensional coherent spectroscopies at short wavelengths.

Published
2019

3. GAUDI: a preparatory archive for the COROT mission

Author

Solano, E., Catala, C., Garrido, R., Poretti, E., Janot-Pacheco, E., Gutierrez, R., Gonzalez, R., Mantegazza, L., Neiner, C., Fremat, Y., Charpinet, S., Weiss, W., Amado, P. J., Rainer, M., Tsymbal, V., Lyashko, D., Ballereau, D., Bouret, J. C., Hua, T., Katz, D., Lignieres, F., Luftinger, T., Mittermayer, P., Nesvacil, N., Soubiran, C., Veer-Menneret, C. Van't, Goupil, M. J., Costa, V., Rolland, A., Antonello, E., Bossi, M., Buzzoni, A., Rodrigo, C., Aerts, C., Butler, C. J., Guenther, E., and Hatzes, A.

Subjects
Astrophysics
Abstract

The GAUDI database (Ground-based Asteroseismology Uniform Database Interface, http://sdc.laeff.esa.es/gaudi/) is a preparatory archive for the COROT (COnvection, ROtation and planetary Transits, http://www.astrsp-mrs.fr/projets/corot/) mission developed at LAEFF (Laboratory for Space Astrophysics and Theoretical Physics, http://www.laeff.esa.es). Its intention is to make the ground-based observations obtained in the preparation of the asteroseismology programme available in a simple and efficient way. It contains spectroscopic and photometric data together with inferred physical parameters for more than 1500 objects gathered since January 1998 in 6 years of observational campaigns. In this paper, the main functionalities and characteristics of the system are described. The observations have been collected at ESO-La Silla, Telescopio Nazionale Galileo, Observatoire de Haute-Provence, South African Astronomical Observatory, Tautenberg Observatory and Sierra Nevada Observatory., Comment: 12 pages, 3 figures (quality degraded). Accepted for publication in The Astronomical Journal

Published
2004
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5. The multiperiodicity of the $\gamma$ Doradus stars HD 224945 and HD 224638 as detected from a multisite campaign

Author

Poretti, E., Koen, C., Bossi, M., Rodriguez, E., Martin, S., Krisciunas, K., Akan, M. C., Crowe, R., Wilcox, M., Ibanoglu, C., and Evren, S.

Subjects
Astrophysics
Abstract

We discuss new photometric data collected on the gamma Dor variables HD 224945 and HD 224638. Multiperiodicity was detected in both stars, thanks to the clear spectral window of a multisite campaign that involved five observatories. HD 224945 shows the shortest period among the gamma Dor stars, i.e., 0.3330 d. The pulsation behaviour is very different: HD 224945 displays a set of frequencies spread over an interval much wider than that of HD 224638. We clearly found evidence for amplitude variations in the excited modes by comparing data from different years. HD 224945 and HD 224638 are among the best examples of $\gamma$ Dor stars that show multimode pulsations, which make them very interesting from an asteroseismological point of view., Comment: 8 pages (in A&A style), 3 eps figures. Accepted for A&A Main Journal

Published
2002
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6. Variable stars in nearby galaxies. II. Population I and II Cepheids in Field A of IC 1613

Author

Antonello, E., Mantegazza, L., Fugazza, D., and Bossi, M.

Subjects
Astrophysics
Abstract

The light curves of Cepheids and other variable stars in Field A of IC 1613, obtained with a CCD and no filter ($Wh$ photometry), have been analyzed. It is possible to separate first overtone from fundamental mode population I Cepheids taking into account the pulsation amplitude, the shape of the light curve and the period. The expected separation is verified in the period--luminosity $PL$ diagram. Light curve Fourier parameters have been compared with those of Magellanic Clouds and galactic Cepheids, in order to point out the effects of the very low metallicity of IC 1613 on the light curve shape. Population II Cepheids of IC 1613 can be discriminated from those of population I in the $PL$ diagram, and, taking into account their color, from other red or blue variables. Their $PL$ relation is consistent with that observed in globular clusters, nearby dwarf spheroidal galaxies and LMC. We have shown it is possible to apply the single-phase method for deriving standard photometry $PL$ relations for population I and II Cepheids; therefore with just one accurate $BVRI$ observation it is possible to use the population I Cepheids for distance determinations. Some unusual stars have been identified on the basis of periods, light curve shapes and colors; they appear to be pulsating stars laying on the extension of $PL$ relation of known anomalous Cepheids. A firmer classification of these and other faint stars requires further deeper multicolor observations., Comment: 9 pages, 11 figures; submitted to Astronomy and Astrophysics

Published
1999

7. Variable stars in nearby galaxies. I. Search for Cepheids in Field A of IC 1613

Author

Antonello, E., Mantegazza, L., Fugazza, D., Bossi, M., and Covino, S.

Subjects
Astrophysics
Abstract

The first results are presented of a four-year program dedicated to the CCD observations of Cepheids in the nearby galaxy IC 1613. Since the program was carried out with a relatively small telescope, the Dutch 0.9 m at ESO-La Silla, the observations were performed without filter (white light), or Wh-band; the advantage of this technique is that the photon statistics correspond to that of V-band observations made with larger telescopes than 2 m and similar exposure time. The effective wavelength of the Wh-band is intermediate between that of V and R bands for stars of A-G spectral type, for back-illuminated CCD detectors. The analysis of the observations of Field A revealed the presence of about 110 variable stars. The detected population I Cepheids are 43; 9 Cepheids were already known from previous works, while most of the new stars have a short period P. For stars with P > 5 d and sufficient phase coverage it is possible to perform good Fourier decomposition of light curves with resulting standard deviation of the fit of 0.02 - 0.04 mag. There are several Cepheids with relatively small amplitude, and most of them are first overtone mode pulsators; the faintest detected Cepheids have V about 23 and P about 1 day. At least 5 population II Cepheids and 8 eclipsing binaries have been observed. The other variable stars are probable long period, semiregular and irregular variables. A comparison with results of other massive CCD photometric projects dedicated to the detection of variable stars shows some advantages of the observations in white light for fully exploiting the capabilities of relatively small telescopes. A suggestion is made on how to use these results for distance determinations., Comment: 17 pages, 15 figures; accepted for publication in Astronomy and Astrophysics

Published
1999

8. Simultaneous intensive photometry and high resolution spectroscopy of delta Scuti stars. III. Mode identifications and physical calibrations in HD 2724

Author

Bossi, M., Mantegazza, L., and Nunez, N. S.

Subjects
Astrophysics
Abstract

On the basis of our new simultaneous photometry and spectroscopy (885 uvby differential measurements in 11 nights and 154 spectrograms of the FeII 4508 A region in 5 nights), we can detect 12 probable periodicities in the variability pattern of this star, determining the frequencies of 7 without any ambiguity. Through a direct fit of pulsational models to our data, we estimate the inclination of rotational axis to be about 50 deg. and get a reliable identification of 4 modes as well as useful bits of information about the others: no retrograde mode is visible, whereas the star seems to show a certain preference for purely sectorial prograde oscillations. Finally, the attribution of our lowest frequency to the radial fundamental pulsation allows a new calibration of physical parameters. In particular, the gravity can be determined with unusual accuracy and the luminosity evaluation becomes more consistent with the Hipparcos astrometry., Comment: 9 pages, 9 figures. To be published in A&A

Published
1998

9. The Gamma Doradus variables, a new class of pulsating stars. The case of HD 224945

Author

Poretti, E., Akan, C., Bossi, M., Koen, C., Krisciunas, K., and Rodriguez, E.

Subjects
Astrophysics
Abstract

A multisite campaign involving five observatories allowed us to solve the light curve of the Gamma Doradus star HD 224945. The multiperiodic content, the high frequency term at 3.00 c/d and the frequency spacing between the observed terms strongly support its pulsational nature. Considering the low frequency terms observed in Gamma Dor stars, it seems that g--mode pulsators can be found near the cold border of the instability strip., Comment: 2 pages, latex, 1 figure To be publishing in the Proceedings of the IAU Symposium 181 'Sounding Solar and Stellar Interior', Nice, 30 Sept-3 Oct, 1996

Published
1996

10. Morphological and functional study of the caudal nerve in a rat model of peripheral neuropathy

Author

Alberti, P, Pozzi, E, Monza, L, Chiorazzi, A, Canta, A, Ballarini, E, Rodriguez-Menendez, V., Bossi, M, Crippa, L, Marmiroli, M, Cavaletti, G, Alberti, P, Pozzi, E, Monza, L, Chiorazzi, A, Canta, A, Ballarini, E, Rodriguez-Menendez, V, Bossi, M, Crippa, L, Marmiroli, M, and Cavaletti, G

Subjects
BIO/16 - ANATOMIA UMANA, caudal nerve, morphology, electron microscpy, neurophysiology, optic microscopy
Published
2022

12. Mesh & Prosthesis

Author

Ferzoco, S., Clara, E. Sta., Tang, S. W., Hu, J., Tan, W. B., Shabbir, A., Lomanto, D., Etherson, K., Atkinson, K., Khan, S., Gwiti, P., Viswanath, Y., Munipalle, P. C., Berrevoet, F., Dhondt, L., Vanlander, A., Matos-Azevedo, A. M., Fatás Cabeza, J. A., Zaragoza-Fernández, C., Marín, J., Navarro, F., Rose, B., Morfesis, F., Armstrong, N., Das Mohapatra, S., O’Hara, J., Camp, C., Hughes, D., Windsor, A. C. J., Blair, L., Cox, T., Huntington, C., Oommen, B., Kim, M., Lincourt, A., Augenstein, V., Heniford, T., Srivastava, K., Martindale, R., Scott, J., Rosen, M., Ray, D., Bossi, M., Tabbara, M., Carandina, S., Polliand, C., Barrat, C., Berta, R., Wong, C., Yang, P. C., Cheung, P. P., Chung, T. M., Chan, C. Y., Lai, C. H., Tang, C. N., Li, K. W., Shen, Y. M., Li, Q., Chen, J., Sun, L., Chen, F. Q., Sharma, M., Satija, N., Mitura, K., Garnysz, K., Skolimowska-Rzewuska, M., Wyrwas, K., Kumar, S., Lee, S., Alves, A., Pompee, C., Chirat, S., Drevon-Gaillot, E., Clermont, G., Tung, K., and Yang, G.

Published
2015
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13. Topic: Inguinal Hernia — Post op chronic pain: incidence, evaluation, legal consequences, therapy, follow up

Author

Zwaans, W., Verhagen, T., Roumen, R., Scheltinga, M., Dieleman, J., Vad, M., Frost, P., Rosenberg, J., Svendsen, S. W., Tabbara, M., Carandina, S., Bossi, M., Polliand, C., Barrat, C., Soler, M., Chander, J., Sharma, R., Lal, R., Pradhan, G., Mol, F., Mitura, K., Romanczuk, M., Lundstrom, K., Nordin, P., Holmberg, H., Sahin, A., Kulacoglu, H., Olcucuoglu, E., Guadalaxara, A., Rampinelli, L. A., Mariani, P., Ubezio, D., Felici, A., Santagati, G., Novellino, L., Gitelis, M., DeAsis, F., Chao, S., Lapin, B., Denham, W., Linn, J., Haggerty, S., Carbray, J., Ujiki, M., Evans, L., Canciani, G. N., Gordon, E. M., Wei, P., Tam, K., Chen, C., Kao, C., Protasov, A., Bogdanov, D., Meshkov, M., Kurganov, I., Misra, M. C., Bansal, V. K., Subodh, K., Krishna, A., Bansal, D., Ray, S., Rajeshwari, S., Marzo, F., Forni, S., Massi, M., Gia, L., and Dabrowski, A.

Published
2015
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19. Assessment of oxaliplatin-induced peripheral neurotoxicity with different treatment schedules

Author

Pozzi, E, Alberti, P, Canta, A, Chiorazzi, A, Fumagalli, G, Meregalli, C, Monza, L, Oggioni, N, Rodriguez-Menendez, V, Ballarini, E, Bossi, M, Cavaletti, G, Marmiroli, P, Pozzi, E, Alberti, P, Canta, A, Chiorazzi, A, Fumagalli, G, Meregalli, C, Monza, L, Oggioni, N, Rodriguez-Menendez, V, Ballarini, E, Bossi, M, Cavaletti, G, and Marmiroli, P

Subjects
oxaliplatin, neurotoxicity, mice
Published
2019

21. Poster display I clinical general

Author

Gurgenyan, S. V. Svetlana, Vatinyan, S. K. H., Nicogosyan, K. G., Edilyan, L. B., Chobanyan, B. G., Graf, S., Beheshti, M., Kienast, O., Oezer, S., Angelberger, P., Dudczak, R., Li, S. Shuren, Azevedo, J. C. Jader, Félix, R. C., Corrêa, P. L., Barbirato, G. B., Mesquita, E. T., Volschan, A., Dohmann, H. F., Mesquita, C. T., Peix, A. Amalia, Hidalgo, J., Dorticos, E., Llerena, L., Paredes, A., Macias, C., Valle, L. Del, Cortinas, L., Torres, M., Ponce, F., Petersen, C. L. Claus Leth, Appel, J., Kjaer, A., Awadalla, H. Hany, Hamed, R., Jamal, M., Rayan, M., Mahmoodi, A., Awaad, O., Demerdash, S. El, Adel, A., Kader, M. Abdel, Sarda-Mantel, L. Laure, Michel, J. B., Rouzet, F., Martet, G., Louedec, L., Raguin, O., Vrigneaud, J. M., Saumon, G., Khaw, B. A., Guludec, D. Le, Delahaye, N. Nicolas, Dinanian, S., Slama, M. S., Sarda, L., Tamas, C., Samuel, D., Adams, D., Syrota, A., Moralidis, E. Efstratios, Spyridonidis, T., Arsos, G., Karatzas, N., Karakatsanis, K., Koutelou, M. Maria, Theodorakos, A., Kollaros, N., Manginas, A., Graphakos, S., Tsapaki, V., Kouzoumi, A., Cokkinos, D., Goussetis, E., Prassopoulos, V. Vassilios, Parthenakis, F., Patrianakos, A., Velidaki, A., Koukouraki, S., Papadimitriou, E., Diakakis, G., Maurakis, H., Karakavitsas, N., Vardas, P., Koszegi, Z. Zsolt, Jenei, C., Varga, J., Galuska, L., Edes, I., Ray, Soumendranath, Kundu Bijon, Sarma S K., Day N R., Skouse, D. Douglas, Florimonte, L., Maffioli, L., Piatti, L., Calegari, M., Mancini, R., Bossi, M., Carboni, G. P. Gian Piero, Toriyama, T., Takase, H. Hiroyuki, Okado, T, Tanaka, S., Dohi, Y., Yasuhi, W. Watanabe, Akihiro, S., Akio, Y., Yasunori, W., Kimio, T., Nariaki, E., Yasuhiko, T., Ryo, K., Kasama, S. Shu, Honjo, T., Ichikawa, S., Toyama, T., Kurabayashi, M., Furuhashi, T. Tatsuhiko, Moroi, M., Kunimasa, T., Fukuda, H., Sugi, K., Takeishi, Y. Yasuchika, Arimoto, T., Kubota, I., Kambara, N. Naoshige, Hosokawa, R., Ohba, M., Saito, K., Motomura, H., Kanoi, T., Kume, N., Saji, H., Kita, T., Nohara, R., Akashi, Y. J. Yoshihiro, Musha, H., Kida, K., Suzuki, K., Inoue, K., Kawasaki, K., Hashimoto, N., Miyake, F., Yokoyama, Y. Yasuhiro, Sato, A., Nozato, T., Takahashi, A., Isobe, M., Aonuma, K., Hiroe, M., Peovska, I. Irena, Bosevski, M., Pavlovic, J.Maksimovic, Vavlukis, M., Vallejo, E. Enrique, Rodriguez, G., Jimenez, L., Hernandez, S., Bialostozky, D., Orea, A. Arturo, Asensio, E., Castillo, L., Dorantes, J., Narvaez, R., Gonzalez, O., Zee, P. M. Marc Van der, Verberne, H. J., Straalen, J. P. Van, Fischer, J. C., Sanders, G. T. B., Eck-Smit, B. L. F. Van, Winter, R. J. De, Kostkiewicz, M. Magdalena, Szot, W., Mura, A., Lesniak-Sobelga, A., Olszowska, M., Tracz, W., Ferreira, M. J. Maria Joao, Ferrer-Antunes, A. I., Rodrigues, V., Santos, F., Lima, J., Cerqueira, M. D., Providencia, L. A., Rodrigues, V., Martins, E., Vasconcelos, M. Mariana, Faria, T., Oliveira, A., Garcia, M., Pereira, J., Rocha-Goncalves, F., Lourenço, C. Cândida, Ferrer-Antunes, A., Vieira, H., Martins, R., Franco, F., Providência, L. A., Flotats, A. Albert, Estorch, M., Estorch, M. Montserrat, Mena, E., Camacho, V., Fuertes, J., Rodriguez, A., Flotats, A., Hernandez, M. A., Kulisewsky, J., Carrio, I., Jose-Galcera, J., Caballero-Martínez, A., Jara-Perez, P., Villegas-Garcia, M., Iñigo-García, L., Rosa, J. A. Nuño de la, Florenciano-Sánchez, R., Castillo-Soria, J. F., Valentí-Aldeguer, J. A., Pico-Aracil, F., Martínez-Caballero, A., Villegas-García, M., Castillo-Soria, F., Sánchez-Villanueva, J. G., Rosa, J. A. Nuço de la, Içigo-García, L., Palop, R., Florenciano-Sanchez, R., Lopez-Martínez, I., Jara-Pñrez, P., Rosa, J. A. Nuno de la, Castillo-Soria, F. J., Jara-Pérez, P., Contreras, J., Villegas-Sánchez, M., Obrador, D., Puig, M., Serra-Grima, R., Santaló, M., Carrió, I., Sorensen, J. Jens, Frostfeldt, G., Lindahl, B., Valind, S., Wallentin, L., Somsen, G. A. Aernout, Burri, H., Zaza, S., Fleury, E., Righetti, A., Entok, E. Emre, Birdane, A., Cavusoglu, Y., Ak, I., Timuralp, B., Haworth, M. J., Mitchell, A. R. J. Andrew, Gardner, M. A., Ormerod, O. J. M., Clements, I. P. Ian, Mullan, B. P., MacGregor, C. G., Breen, J. F., Akinboboye, O. O., Nichols, K. J., Wang, Y., Dim, U. Uzodinma, Lachman, J., Nichols, K. J., Muratore, K. A., Aracely, N., Haag, E. S., Druz, R. S. Regina, Gopal, A. S., Borges, A., Ngai, K. C., Dim, U. R., Wiley, M., Freeman, J., Kitchen, S., Graham, D., Schindel, M., Clark, E., Speiser, D., Hackney, T., Feldkamp, M., and Rosamond, T. Thomas

Published
2005
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24. ETNK1 mutations promote ROS production and DNA damage through increased mitochondrial activity

Author

Fontana, D, Mauri, M, Niro, A, Massimino, L, Bertagna, M, Zambrotta, G, Bossi, M, CITTERIO, STEFANIA, Crescenzi, B, Signore, G, Piazza, V, Mecucci, C, Cavaletti, G, Rea, D, Gambacorti-Passerini, C, Piazza, R, Fontana, D, Mauri, M, Niro, A, Massimino, L, Bertagna, M, Zambrotta, G, Bossi, M, Citterio, S, Crescenzi, B, Signore, G, Piazza, V, Mecucci, C, Cavaletti, G, Rea, D, Gambacorti-Passerini, C, and Piazza, R

Subjects
ETNK1, ROS
Abstract

Atypical chronic myeloid leukemia (aCML) is a clonal disorder belonging to the myelodysplastic/myeloproliferative syndromes. About 13% of aCML cases carry somatic mutations in ETNK1 gene, encoding for H243Y, N244S, and G245V substitutions. We previously showed that ETNK1 mutations cause a decreased catalytic activity of the enzyme. Despite this evidence however, their oncogenic role remained largely unexplained. Since ETNK1 activity is essential for the synthesis of phosphatidylethanolamine (PE) and given that PE is one of the most abundant phospholipids in the inner membrane of mitochondria, we focused our attention on mitochondrial activity. In order to characterize the oncogenic effect of ETNK1 variants we generated CRISPR/Cas9 clones carrying heterozygous N244S mutation and homozygous ETNK1 deletion (KO cells) on the 293 Flp-In™ cell-line. Both N244S and KO cells showed a significant increase in mitochondrial activity (1.78 and 2.13 fold increase, respectively; p= 0.0096 and p=0.0050) compared to WT, as assessed by MitoTracker™ Red. In line with this finding, electron microscopy revealed a significant modification in mitochondria morphology for N244S and KO cells, changing from an elongated, tubular shape to a round, swollen one. ATP (1.67 and 1.68 fold; p

Published
2018

25. ETNK1 mutations increase mitochondrial activity and promote DNA damage through ROS production

Author

Fontana, D, Mauri, M, Niro, A, Massimino, L, Bertagna, M, Zambrotta, G, Bossi, M, Citterio, S, Crescenzi, B, Signore, G, Piazza, V, Fanelli, F, Mecucci, C, Cavaletti, G, Rea, D, Gambacorti Passerini, C, Piazza, R, Fontana, D, Mauri, M, Niro, A, Massimino, L, Bertagna, M, Zambrotta, G, Bossi, M, Citterio, S, Crescenzi, B, Signore, G, Piazza, V, Fanelli, F, Mecucci, C, Cavaletti, G, Rea, D, Gambacorti Passerini, C, and Piazza, R

Subjects
atypical chronic myeloid leukemia, mitochondrial activity
Published
2018

29. First Results of an International Multisite Multitechnique Campaign on omicron and

Author

Sareyan, J. P., Chauville, J., Briot, D., Adelman, S. J., Alvarez, M., Balega, I., Balega, Y., Bardin, D., Belkin, I., Bonneau, D., Bossi, M., Desnoux, V., Espoto, M., Fried, R., Gonzalez-Bedolla, S., Guo, X. Z., Guo, Y. L., Hao, J. X., Huang, L., Klotz, A., Leister, N., Morand, F., Mourard, D., Vakili, F., Valera, F., Zhao, F. Y., Balona, Luis A., editor, Henrichs, Huib F., editor, and Le Contel, Jean Michel, editor

Published
1994
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32. Role of somatic ETNK1 mutation in the mitochondrial activity

Author

Fontana, D, Bertagna, M, Mauri, M, Bossi, M, Citterio, S, Crescenzi, B, Signore, G, Piazza, V, Mecucci, C, Cavaletti, G, Gambacorti Passerini, C, Piazza, RG, Fontana, D, Bertagna, M, Mauri, M, Bossi, M, Citterio, S, Crescenzi, B, Signore, G, Piazza, V, Mecucci, C, Cavaletti, G, Gambacorti Passerini, C, and Piazza, R

Subjects
atypical chronic myeloid leukemia, mitochondrial activity
Published
2017

40. Selected Organ Works

Author

Bossi, M. Enrico and Bossi, M. Enrico

Abstract

A collection of exercises, for Organ, composed by M.E. Bossi.

Published
2016

45. Comparative trophic ecology of two sympatric canids in the Brazilian Pampa.

Author

Bossi, M. A. S., Migliorini, R. P., Santos, T. G., and Kasper, C. B.

Subjects
*ANIMAL feeding behavior, *FOX behavior, *MAMMAL habitats, *PREDATION, *COMPETITION (Biology), *MAMMALS
Abstract

Studies on resource utilization by carnivores are essential to assess the role of the species in the ecosystem. These studies help us to understand the mechanisms that influence vertebrate community structure and the relationships between predators and prey. The aims of this study were to compare and describe the food habits of the sympatric Pampas fox (Lycalopex gymnocercus) and crab‐eating fox (Cerdocyon thous) in the Brazilian Pampa, and to evaluate the food niche overlap between them, and infer aspects of habitat preferences on the basis of their prey. For the diet analyses, 25 stomach contents of Pampas foxes and 33 of crab‐eating foxes were collected. We identified 80 prey items (49 for the Pampas fox and 63 for the crab‐eating fox) and grouped them into eight main categories. Mammals and invertebrates were the most frequent items in the diets of both canids, followed by fruits. The trophic niche breadth of the Pampas fox (Bsta = 0.56) was larger than that of the crab‐eating fox (Bsta = 0.47). The diet overlap between them was Ojk = 0.58. However, a PERMANOVA test showed that diets did not differ between species or season. Our results showed that both L. gymnocercus and C. thous had generalist diets, with a great diversity of prey, but based on similar main food items. Items that contributed the most to the diet of the Pampas fox were insects (Gryllotalpidae and Scarabaeidae) and cavies (Cavia aperea) and those that contributed the most to the diet of the crab‐eating fox were fruits of Syagrus romanzoffiana, beetles (Scarabaeidae), amphibians (Leptodactylus spp.) and cavies. This is the first study to describe and compare the food habits of these two species, occurring in sympatry in the Brazilian Pampa. Interspecific competition for food is a critical factor that determines species coexistence in carnivores. In this study we compare and describe the food habits of two sympatric foxes in southern Neotropics, the Pampas fox (Lycalopex gymnocercus) and the crab‐eating fox (Cerdocyon thous). Our results showed that both species had generalist diets, with a great diversity of prey, but based on similar main food items. The foraging strategies of these canids could be associated with the exploration of different microhabitats. This plasticity may be important for the survival of these species under the constant loss of their natural environments, persecution, and other sources of mortality. [ABSTRACT FROM AUTHOR]

Published
2019
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46. Valproate protective effects on cisplatin-induced peripheral neuropathy: An in vitro and in vivo study

Author

Rodriguez-Menendez, V., Gilardini, A., Bossi, M., Canta, A., Oggioni, N., valentina alda carozzi, Tremolizzo, L., Cavaletti, G., RODRIGUEZ MENENDEZ, V, Gilardini, A, Bossi, M, Canta, A, Oggioni, N, Carozzi, V, Tremolizzo, L, and Cavaletti, G

Subjects
Antineoplastic Combined Chemotherapy Protocol, Animal, Valproic Acid, cisplatin, Drug Synergism, Neurite, Rats, Sprague-Dawley, Ganglia, Spinal, valproate, Rat, neuropathy, neuroprotection, Female, Rats, Wistar, Peripheral Nervous System Disease
Abstract

BACKGROUND: Antineoplastic drugs, such as cisplatin (CDDP), induce disabling peripheral neuropathies, representing a hindrance to effective cancer treatments. The exact pathogenesis of CDDP-induced neuropathy is not yet understood, and the dysregulation of gene expression has been proposed. Valproate (VPA) is an antiepileptic drug recently discovered to remodel gene expression, with hypothetically putative neuroprotective effects. MATERIALS AND METHODS: VPA was tested in both, in vitro and in vivo models of CDDP-neurotoxicity. RESULTS: VPA administered in combination with CDDP promoted dorsal root ganglia (DRG) neurons survival. Moreover, this treatment induced in Wistar rats an improvement of body weight, sensory nerve conduction velocity, and DRG morphometric analysis. In contrast, VPA was not able to rescue CDDP pre-treated rats. CONCLUSION: When used in combination with CDDP, VPA displays a protective action against neuropathy, in our models, suggesting possible future clinical applications.

Published
2008

47. Paclitaxel toxicity in post-mitotic dorsal root ganglion (DRG) cells

Author

Scuteri, A., Nicolini, G., Miloso, M., Bossi, M., guido cavaletti, Windebank, A. J., Tredici, G., Scuteri, A, Nicolini, G, Miloso, M, Bossi, M, Cavaletti, G, Windebank, A, and Tredici, G

Subjects
Neurons, Paclitaxel, apoptosis, Antineoplastic Agents, Phytogenic, Rats, Rats, Sprague-Dawley, Neuroblastoma, BIO/16 - ANATOMIA UMANA, Cell Line, Tumor, Ganglia, Spinal, neurotoxicity, necrosi, Neurites, Animals, dorsal root ganglion neuron
Abstract

Paclitaxel is an antineoplastic drug which acts by enhancing tubulin polymerization. The induction of peripheral neuropathy is the main dose-limiting side-effect of paclitaxel treatment. In this study, the neurotoxic effect of this drug in dorsal root ganglion (DRG) explants was analyzed by measuring the neurite length of DRG explants exposed to nerve growth factor (NGF). The neurotoxic effect of paclitaxel is dose- and time-dependent. Moreover, in DRG dissociated post-mitotic neurons, the molecular and morphological features of paclitaxel-induced cellular death were studied and the DRG neurons were observed to die by necrosis. On the contrary, the proliferating human neuroblastoma SH-SY5Y cells exposed to paclitaxel die by apoptosis, as reported for cortical neurons. The different response to the same stimulus of different neuronal populations underlines the importance of the biochemical and molecular phenotype of the neuronal population in determining cellular behavior and vulnerability to the same noxious stimulus.

Published
2006

48. THz coherent transition radiation at TeraFERMI: First characterization of THz radiation and electron beam dynamics

Author

Perucchi, A., primary, Capasso, L., additional, Di Mitri, S., additional, Di Pietro, P., additional, Giorgianni, F., additional, Lupi, S., additional, Svetina, C., additional, Veronese, M., additional, Allaria, E., additional, Badano, L., additional, Bassanese, S., additional, Bossi, M., additional, Diviacco, B., additional, Ferianis, M., additional, Ferrari, E., additional, Gaio, G., additional, Gauthier, D., additional, Gelmetti, F., additional, Giannessi, L., additional, Grulja, S., additional, Milloch, M., additional, Penco, G., additional, Roussel, E., additional, Trovo, M., additional, and Serpico, C., additional

Published
2016
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