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Objective: Sepsis is the most serious complication of flexible ureteroscopy (F-URS) and laser lithotripsy. We assessed the influence of positive stone culture (SC) on major infectious complications (sepsis, septic shock). Methods: This prospective study enrolled adult patients deemed suitable for F-URS and laser lithotripsy from nine centers (January 2022–August 2023). Inclusion criteria were as follows: kidney stone(s), preoperative midstream urine culture (MSUC), stone(s) assessed at computed tomography scan, and SC. Exclusion criteria were as follows: bilateral procedures, ureteral stones, and children. Group 1 included patients with sterile SC. Group 2 included patients with positive SC. Data are presented as median (interquartile range). A multivariable logistic regression analysis was performed to evaluate factors associated with having a positive SC. Results: In total, 293 patients were included. Median age was 51.0 (24) years. There were 167 (57.0%) males. Group 2 included 32 (2.5%) patients. Group 2 patients were significantly older [75.0 (14) vs 51.0 (23) years, p = 0.02]. Stone features were similar. Major infectious complications were higher in Group 2 (15.6% vs 0.4%). One patient died because of sepsis in Group 2. Two out of 6 (33.3%) patients with major infectious complications had the same pathogen in MSUC and SC. In the multivariable regression analysis, diabetes (OR 3.23), symptomatic urinary infections within 3 months before operation (OR 4.82) and preoperative stent/nephrostomy (OR 2.92) were factors significantly associated with higher odds of positive SC. Conclusions: Patients with positive SC have a higher incidence of major infectious complications after F-URS lithotripsy. SC should be performed whenever feasible because there is a poor correlation between MSUC and SC. [ABSTRACT FROM AUTHOR]

Physical activity promotes metabolic health and prevents lifestyle-related diseases. Adiponectin is specifically produced by adipose tissue and comes in three forms, differing in terms of weight: trimers (LMW), hexamers (MMW), and high-molecular-weight (HMW) oligomers. The oligomers are associated with the beneficial effects of adiponectin. In this study, we aimed to investigate the impact of a single bout of exhaustive exercise on adiponectin expression in 25 male amateur athletes, divided into two groups, one comprising young adults (YAs) (n = 15), and the other comprising middle-aged adults (MAs) (n = 10). Body fat was estimated through skinfold thickness. Adiponectin levels were assessed at baseline and at 15 min and 24 h post-exercise, while HMW oligomer levels were evaluated at baseline and at 24 h post-exercise. We observed a significant increase in total adiponectin at both 15 min and 24 h after exercise, with there being a more evident effect among the YA subjects. HMW oligomers also increased significantly after exercise both in the total sample and among the YA subjects, but this was not the case in the MA subjects. The increase in adiponectin levels was significantly associated with Powerpeak. Furthermore, a significant inverse correlation was found between basal adiponectin and VO2peak and Powerpeak. In conclusion, a single bout of exhaustive exercise can rapidly and significantly enhance the basal circulating adiponectin concentration, which seems to be negatively associated with maximal aerobic capacity. [ABSTRACT FROM AUTHOR]

Workplaces cause employees to adopt sedentary behaviors for most of their daytime, negatively impacting psychophysical health. A new office concept (UP150) was designed to reduce sedentary behaviors at work through architectural changes, proactive technologies, and wellness coaches (education to active lifestyles). The present study examined the effects of the UP150 concept, previously investigated in dedicated workspaces, with a 12-month longitudinal trial in a real worksite environment. Forty-eight desk workers comprised the experimental (EG) and control (CG) groups. All participants worked in the same working environment, having the UP150 features inserted in a usual working environment, but the CG was not allowed to interact with the UP150 specifics. During the experimental year, physical (physical activity, motor efficiency, and anthropometric features), clinical (metabolic parameters and cognitive-capacity-related parameters), and psychological (well-being and discomfort, job social and psychological perceptions, and perceived workload) features were assessed. The prolonged application of the UP150 procedure in a mixed working context for involvement in corporate policies positively affected EG workers' physical (physical activity and motor efficiency increased, and body fat unchanged), clinical (blood glucose, insulin, and total cholesterol decreased; HDL increased), and psychological (well-being and social support raised; job demand and perceived workload lowered) parameters, confirming the previous studies. [ABSTRACT FROM AUTHOR]

This study aimed to analyze the acute impact of exercise on serum irisin levels in 22 young (YA, 24.6±3.5 yrs) and in 12 middle-aged male adults (MA, 54.6±5.7 yrs) 15 min and 24 h after an incremental cycling exercise test to exhaustion. ELISA assay was used for serum irisin detection. Circulating irisin increased significantly from baseline (9.0±2.0 ng/ml) to 15 min post-exercise (10.2±2.0 ng/ml, P <0.001), but the greatest increment was detected after 24 h (13.5±2.5 ng/ml, P <0.001) reaching more than 50% of the basal release. Levels were significantly higher in YA (9.7±1.7 to 11.1±1.8 to 14.5±2.2 ng/ml) than MA (7.6±1.6 to 8.7±1.5 to 11.8± 2.2 ng/ml) for all measured time-points (P <0.05). Nevertheless, MA showed a comparable increase in serum irisin levels when compared to YA. These findings highlight the importance of acute physical exercise as a countermeasure against age-related deterioration of skeletal muscle mass and function in both YA and MA. [ABSTRACT FROM AUTHOR]

Purpose: To compare the effects of different modalities of morning priming exercise on afternoon physical performance with the associated hormonal and psychophysiological responses in young soccer players. Methods: In a randomized counterbalanced crossover design, 12 young soccer players completed 3 different morning conditions on 3 different days: repeated-sprint running (6 x 40 m), easy exercise (4 x 12 fast half squats, 6 speed ladder drills, and 20-m sprints), and control (no exercise). Blood testosterone and cortisol concentrations were assessed upon arrival (approximately 8:30AM) and approximately 5 hours and 30 minutes later. Body temperature, self-reported mood, quadriceps neuromuscular function (maximal voluntary contraction, voluntary activation, rate of torque development, and twitch contractile properties), jump, and sprint performance were evaluated twice per day, while rating of perceived exertion, motivation, and the Yo-Yo Intermittent Recovery level 2 (IR2) tests were assessed once per day. Results: Compared with the control, repeated-sprint running induced a possible positive effect on testosterone (+11.6%) but a possible to very likely negative effect on twitch contractile properties (-13.0%), jump height (-1.4%), and Yo-Yo IR2 (-7.1%). On the other hand, easy exercise had an unclear effect on testosterone (-3.3%), resulted in lower self-reported fatigue (-31.0%) and cortisol (-12.9%), and had a possible positive effect on the rate of torque development (+4.3%) and Yo-Yo IR2 (+6.5%) compared with the control. Conclusions: Players' testosterone levels were positively influenced by repeated-sprint running, but this did not translate into better physical function, as both muscular and endurance performance were reduced. Easy exercise seemed to be suitable to optimize the physical performance and psychophysiological state of young soccer players. [ABSTRACT FROM AUTHOR]

Purpose: Understanding the dose-response relationship between internal and external training load with changes in aerobic fitness and intermittent running capacity, during different periods of the season, may help in optimizing training process. The aim of the present study was to investigate the dose-response relationships between load measures and changes in aerobic fitness and intermittent running capacity among a large cohort of professional soccer players. Methods: Training load, aerobic fitness and intermittent running capacity of 52 male adult professional players from 3 elite teams were monitored across an entire season and analyzed employing linear mixed models, with a significance level set at p≤0.05. Results: Relationships between load measures (training and match duration, sRPE-TL, total distance, high and very high-speed running distances) and changes in physical qualities were stronger during the preparation period (PREP) for both aerobic fitness (d= 0.48 to 0.76, p<0.031) and intermittent running capacity (d= 0.46 to 1.89, p<0.046). The magnitude of the relationships reduced during the first competitive period (d= 0.43 to 0.56) and the relationships became trivial in the second competitive period (d= 0.06 to 0.41, p= 0.063 to 0.846). Conclusion: The moderate to large relationships found between all measures of load and changes in physical capacities suggest that training prescription during the PREP was effective in improving players' fitness. During the competitive phase small changes in aerobic and intermittent running capacities were found, highlighting that coaching staff pursue different aims during the competitive period, such as technical and tactical training and recovery. [ABSTRACT FROM AUTHOR]

Purpose: To examine differences between adult male basketball players of different competitive levels (study 1) and changes over a basketball season (study 2) of knee-extensor peripheral muscle function during multistage change-of-direction exercise (MCODE). Methods: In study 1,111 players from 4 different divisions completed the MCODE during the regular season. In study 2, the MCODE was performed before (Tl) and after (T2) the preparation period and during the competitive season (T3) by 32 players from divisions I, II, and 111. The MCODE comprised 4 levels of increasing intensity for each player. The twitch peak torque (PT) of knee extensors was measured after each level. PTmax (the highest value of PT) and fatigue were calculated. Results: In study 1, the authors found possibly small differences (effect size [ES] [90% confidence interval] -0.24 [0.39]) in fatigue between divisions I and II. Division 1 was characterized by likely (ES 0.30-0.65) and very likely to almost certain (ES 0.74-1.41) better PTmax and fatigue levels than divisions III and VI, respectively. In study 2. fatigue was very likely reduced (ES -0.91 to -0.51) among all divisions from T1 to T2, whereas PTmax was likely to very likely reduced (ES -0.51 to -0.39) in divisions II and III. Conclusions: Professional basketball players are characterized by a better peripheral muscle function during MCODE. Most of the seasonal changes in peripheral muscle function occurred after the preparation period. These findings inform practitioners on the development of training programs to enhance the ability to sustain repeated change-of-direction efforts. [ABSTRACT FROM AUTHOR]