49 results on '"Bosgra, Sieto"'
Search Results
2. Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity
3. Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide
4. Human glycemic response curves after intake of carbohydrate foods are accurately predicted by combining in vitro gastrointestinal digestion with in silico kinetic modeling
5. OSWG Recommended Approaches to the Nonclinical Pharmacokinetic (ADME) Characterization of Therapeutic Oligonucleotides
6. P816: PHARMACODYNAMIC ACTIVITY OF GEN3014 (HEXABODY-CD38) IN PATIENTS WITH MULTIPLE MYELOMA SUPPORTS ENHANCED COMPLEMENT DEPENDENT CYTOTOXICITY OF GEN3014 COMPARED TO DARATUMUMAB
7. Next Generation Exon 51 Skipping Antisense Oligonucleotides for Duchenne Muscular Dystrophy
8. Interpreting in vitro developmental toxicity test battery results: The consideration of toxicokinetics
9. Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context
10. Preliminary Dose-Escalation Results from a Phase 1/2 Study of GEN3014 (HexaBody (R)-CD38) in Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM)
11. Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling
12. Preliminary Dose-Escalation Results from a Phase 1/2 Study of GEN3014 (HexaBody®-CD38) in Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM)
13. Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay
14. To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics
15. Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
16. Toxicokinetic Triage for Environmental Chemicals
17. An integrated probabilistic framework for cumulative risk assessment of common mechanism chemicals in food: An example with organophosphorus pesticides
18. Probabilistic cumulative risk assessment of anti-androgenic pesticides in food
19. A model for probabilistic health impact assessment of exposure to food chemicals
20. Toxicodynamic analysis of the combined cholinesterase inhibition by paraoxon and methamidophos in human whole blood
21. Toxicodynamic analysis of the inhibition of isolated human acetylcholinesterase by combinations of methamidophos and methomyl in vitro
22. Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach
23. Preclinical Anti-Tumor Activity of Hexabody-CD38 in Patient-Derived B Cell Lymphoma and Acute Myeloid Leukemia Xenograft Models
24. Proceedings in uncovering the mechanism behind peroxisome proliferator-induced hepatocarcinogenesis
25. Probabilistic risk characterization: An example with di(2-ethylhexyl) phthalate
26. The Pharmacokinetics of 2′-O-Methyl Phosphorothioate Antisense Oligonucleotides: Experiences from Developing Exon Skipping Therapies for Duchenne Muscular Dystrophy
27. Nonclinical Exon Skipping Studies with 2′-O-Methyl Phosphorothioate Antisense Oligonucleotides in mdx and mdx-utrn−/− Mice Inspired by Clinical Trial Results
28. Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26 Al Microtracer Approach
29. High Throughput Pharmacokinetics for Environmental Chemicals
30. Availability of Polychlorinated Biphenyls (PCBs) and Lindane for Uptake by Intestinal Caco-2 Cells
31. Assuring Safety without Animal Testing concept (ASAT): Systems toxicology supported data infrastructure for human risk assessment
32. Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay
33. Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26Al Microtracer Approach.
34. Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context
35. Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
36. To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics
37. Assuring safety without animal testing concept (ASAT). Integration of human disease data with in vitro data to improve toxicology testing
38. Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
39. Human glycemic response curves after intake of carbohydrate foods are accurately predicted by combining in vitrogastrointestinal digestion with in silicokinetic modeling
40. An expert consortium review of the EC-commissioned report 'alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010'
41. Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach
42. An improved model to predict physiologically based model parameters and their inter-individual variability from anthropometry
43. Integrated testing strategy for reproductive toxicity
44. Extrapolation of toxic concentrations in in vitro assays by a high throughput PBPK model
45. Human risk assessment—Choosing the appropriate dose metric by PBPK-modeling
46. Dose addition and the isobole method as approaches for predicting the cumulative effect of non-interacting chemicals: A critical evaluation
47. An integrated framework for probabilistic cumulative risk assessment of chemicals in food
48. Human embryonic stem cell-derived test systems for developmental neurotoxicity: A transcriptomics approach
49. An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010".
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