Search

Your search keyword '"Boschi, Stefano"' showing total 311 results
Start Over Author "Boschi, Stefano"
311 results on '"Boschi, Stefano"'

5. Synthesis and preclinical evaluation of an Al18F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand

Author

Boschi, Stefano, Lee, Jason T, Beykan, Seval, Slavik, Roger, Wei, Liu, Spick, Claudio, Eberlein, Uta, Buck, Andreas K, Lodi, Filippo, Cicoria, Gianfranco, Czernin, Johannes, Lassmann, Michael, Fanti, Stefano, and Herrmann, Ken

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Urologic Diseases, Bioengineering, Cancer, Biomedical Imaging, Prostate Cancer, Animals, Antigens, Surface, Biomarkers, Tumor, Cell Line, Tumor, Drug Evaluation, Preclinical, Edetic Acid, Fluorine Radioisotopes, Gallium Isotopes, Gallium Radioisotopes, Glutamate Carboxypeptidase II, Isotope Labeling, Male, Metabolic Clearance Rate, Mice, Mice, Inbred C57BL, Oligopeptides, Organ Specificity, Organometallic Compounds, Positron-Emission Tomography, Prostatic Neoplasms, Radiation Dosage, Radiation Exposure, Radiopharmaceuticals, Reproducibility of Results, Sensitivity and Specificity, Tissue Distribution, Whole-Body Counting, PET, PSMA, F-18, Dosimetry, Preclinical, Prostate cancer, 18F, Other Physical Sciences, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

PurposeThe aim of this study was to synthesize and preclinically evaluate an 18F-PSMA positron emission tomography (PET) tracer. Prostate-specific membrane antigen (PSMA) specificity, biodistribution, and dosimetry in healthy and tumor-bearing mice were determined.MethodsSeveral conditions for the labeling of 18F-PSMA-11 via 18F-AlF-complexation were screened to study the influence of reaction temperature, peptide amount, ethanol volume, and reaction time. After synthesis optimization, biodistribution and dosimetry studies were performed in C57BL6 mice. For proof of PSMA-specificity, mice were implanted with PSMA-negative (PC3) and PSMA-positive (LNCaP) tumors in contralateral flanks. Static and dynamic microPET/computed tomography (CT) imaging was performed.ResultsQuantitative labeling yields could be achieved with >97 % radiochemical purity. The 18F-PSMA-11 uptake was more than 24-fold higher in PSMA-high LNCaP than in PSMA-low PC3 tumors (18.4 ± 3.3 %ID/g and 0.795 ± 0.260 %ID/g, respectively; p

Published
2016

17. L'Africa di Francesco Petrarca. Con particolare riferimento al libro VI tradotto e commentato

Author

Boschi, Stefano

Subjects
fasi di stesura, Petrarca, traduzione, intertestualità, storia dell'Africa, esegesi, libro VI, grande lacuna, commento, Africa, revisione, rassegna traduzioni, analisi delle fonti, Settore L-FIL-LET/04 - Lingua e Letteratura Latina, Settore L-FIL-LET/10 - Letteratura Italiana, Settore L-FIL-LET/08 - Letteratura Latina Medievale e Umanistica
Published
2023

39. Production and Quality Control of [ 177 Lu]Lu-PSMA-I&T: Development of an Investigational Medicinal Product Dossier for Clinical Trials.

Author

Di Iorio, Valentina, Boschi, Stefano, Cuni, Cristina, Monti, Manuela, Severi, Stefano, Paganelli, Giovanni, and Masini, Carla

Subjects
*PRODUCTION control, *CLINICAL trials, *RADIOCHEMICAL purification, *VITAMIN C, *PROSTATE cancer, *QUALITY control
Abstract

Since prostate cancer is the most commonly diagnosed malignancy in men, the theranostic approach has become very attractive since the discovery of urea-based PSMA inhibitors. Different molecules have been synthesized starting from the Glu-urea-Lys scaffold as the pharmacophore and then optimizing the linker and the chelate to improve functional characteristics. This article aimed to highlight the quality aspects, which could have an impact on clinical practice, describing the development of an Investigational Medicinal Product Dossier (IMPD) for clinical trials with [177Lu]Lu-PSMA-I&T in prostate cancer and other solid tumors expressing PSMA. The results highlighted some important quality issues of the final preparation: radiolabeling of PSMA-I&T with lutetium-177 needs a considerably longer time compared with the radiolabeling of the well-known [177Lu]Lu-PSMA-617. When the final product was formulated in saline, the stability of [177Lu]Lu-PSMA-I&T was reduced by radiolysis, showing a decrease in radiochemical purity (<95% in 24 h). Different formulations of the final product with increasing concentrations of ascorbic acid have been tested to counteract radiolysis and extend stability. A solution of 20 mg/mL of ascorbic acid in saline prevents radiolysis and ensures stability over 30 h. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

47. Potential pitfalls of 18F-FDG PET in a large series of patients treated for malignant lymphoma: prevalence and scan interpretation

Author

Castellucci, Paolo, Nanni, Cristina, Farsad, Mohsen, Alinari, Lapo, Zinzani, PierLuigi, Stefoni, Vittorio, Battista, Giuseppe, Valentini, Daria, Pettinato, Cinzia, Marengo, Mario, Boschi, Stefano, Canini, Romeo, Baccarani, Michele, Monetti, Nino, Franchi, Roberto, Rampin, Lucia, Fanti, Stefano, and Rubello, Domenico

Published
2005
Full Text
View/download PDF

48. Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease

Author

Belluzzi, Andrea, Brignola, Corrado, Campieri, Massimo, Pera, Angelo, Boschi, Stefano, and Miglioli, Mario

Subjects
Crohn's disease -- Diet therapy, Fish oils -- Evaluation, Enteric-coated tablets -- Evaluation
Abstract

Enteric-coated fish oil capsules may be beneficial in the treatment of Crohn's disease. Crohn's disease is an inflammatory bowel disease. Thirty-nine people in remission from Crohn's disease took three enteric-coated capsules containing 500 milligrams of fish oil three times a day and 39 took a placebo. They were examined at the beginning of the study and again at 3, 6, 9 and 12 months. Twenty-eight percent of those taking fish oil had a relapse, compared to 69% of those taking a placebo. At 12 months, 59% of those taking fish oil were still in remission, compared to 26% of those taking a placebo. Blood tests revealed a significant drop in chemicals involved in inflammatory processes in the people taking fish oil. Analysis of red blood cells from patients in remission indicated that the fatty acids in the fish oil had been incorporated into the red cell membranes. Four of those taking fish oil dropped out of the study because of diarrhea.

Published
1996

Catalog

Books, media, physical & digital resources
See catalog results