1. Evaluation of Health-Related Quality of Life according to Carbohydrate Metabolism Status: A Spanish Population-Based Study (Di@bet.es Study)
- Author
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Rafael Carmena, Inmaculada Mora-Peces, Galder Gutierrez, Juan Girbés, Gemma Pascual-Manich, Federico Soriguer, E. Menéndez, Emilio Ortega, Roger R. Gomis, Elena Bordiú, Sonia Gaztambide, Miguel Catalá, Luis Castaño, Josep Franch, Sergio Valdés, Manuel Fuentes, Gemma Rojo-Martínez, Manuel Serrano-Ríos, Joan Vendrell, Albert Goday, Elías Delgado, Clara Marcuello, Anna Bosch-Comas, Alfonso Calle-Pascual, Roser Casamitjana, María Teresa Martínez-Larrad, J.A. Vázquez, Conxa Castell, Isabelle Runkle, Alfonso López-Alba, [Marcuello,C, Calle-Pascual,AL, Runkle,I] Department of Endocrinology and Nutrition, Hospital Clínico San Carlos de Madrid, Madrid, Spain. [Fuentes,M] Preventive Medicine Service, Hospital Clínico San Carlos de Madrid, Madrid, Spain. [Soriguer,F, Bosch-Comas,A, Carmena,R, Casamitjana,R, Castaño,L, Catalá,M, Gaztambide,S, Gomis,R, Gutiérrez,G, Martínez-Larrad,MT, Ortega,E, Pascual-Manich,G, Rojo-Martínez,G, Serrano-Rios,M, Valdés,S, Vendrell,J] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain. [Soriguer,F, Valdés,S] Department of Endocrinology and Nutrition, Hospital Regional Universitario Carlos Haya Málaga, Málaga, Spain. [Goday,A] Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain. [Bosch-Comas,A, Ortega,E] Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [Bordiú,E] Laboratorio de Endocrinología, Hospital Clínico San Carlos de Madrid, Madrid, Spain. [Carmena,R, Catalá,M] Department of Medicine and Endocrinology, Hospital Clínico Universitario de Valencia, Valencia, Spain. [Casamitjana,R] Biomedic Diagnostic Centre, Hospital Clínic de Barcelona, Barcelona, Spain. [Castaño,L, Gutiérrez,G] Diabetes Research Group, Hospital Universitario de Cruces, UPV-EHU, Barakaldo, Spain. [Castell,C] Public Health Division, Department of Health, Autonomous Government of Catalonia, Barcelona, Spain. [Delgado,E, Menéndez,E] Department of Endocrinology and Nutrition, Hospital Central de Asturias, Oviedo, Spain. [Franch,J] EAP Raval Sud, Institut Català de la Salut, Red GEDAPS, Primary Care, Unitat de Suport a la Recerca (IDIAP—Fundació Jordi Gol), Barcelona, Spain. [Girbés,J] Diabetes Unit, Hospital Arnau de Vilanova, Valencia, Spain. [Gomis,R, Ortega,E] Endocrinology and Diabetes Unit, Hospital Clínic de Barcelona, Universitat de Barcelona (UB), Barcelona, Spain. [López-Alba,A] Spanish Diabetes Society, Madrid, Spain. [Martínez-Larrad,MT, and Serrano-Rios,M] Lipids and Diabetes Laboratory, Hospital Clínico San Carlos de Madrid, Madrid, Spain. [Mora-Peces,I] Canarian Health Service, Tenerife, Spain. [Vázquez,JA] Diabetes National Plan, Ministry of Health, Madrid, Spain. [Vendrell,J] Department of Endocrinology and Nutrition, Hospital Universitario Joan XXIII, Institut d’Investigacions Sanitaries Pere Virgili, Tarragona, Spain.
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Gerontology ,Article Subject ,Endocrinology, Diabetes and Metabolism ,España ,Estudios Transversales ,Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings] ,Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings] ,Logistic regression ,Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Regression Analysis::Logistic Models [Medical Subject Headings] ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus [Medical Subject Headings] ,Named Groups::Persons::Men [Medical Subject Headings] ,Endocrinology ,Quality of life ,Disciplines and Occupations::Social Sciences::Quality of Life [Medical Subject Headings] ,Diabetes mellitus ,Metabolismo de los Hidratos de Carbono ,medicine ,Named Groups::Persons::Age Groups::Adult [Medical Subject Headings] ,Modelos Logísticos ,Prediabetes ,Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Regression Analysis [Medical Subject Headings] ,Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Sampling Studies [Medical Subject Headings] ,Análisis de Regresión ,Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings] ,lcsh:RC648-665 ,Endocrine and Autonomic Systems ,business.industry ,Odds ratio ,Anthropometry ,medicine.disease ,Obesity ,Muestreo ,humanities ,Named Groups::Persons::Women [Medical Subject Headings] ,Glucosa ,Calidad de Vida ,business ,Body mass index ,Phenomena and Processes::Metabolic Phenomena::Metabolism::Carbohydrate Metabolism [Medical Subject Headings] ,Demography ,Research Article - Abstract
Objective. To evaluate the association between diabetes mellitus and health-related quality of life (HRQOL) controlled for several sociodemographic and anthropometric variables, in a representative sample of the Spanish population.Methods. A population-based, cross-sectional, and cluster sampling study, with the entire Spanish population as the target population. Five thousand and forty-seven participants (2162/2885 men/women) answered the HRQOL short form 12-questionnaire (SF-12). The physical (PCS-12) and the mental component summary (MCS-12) scores were assessed. Subjects were divided into four groups according to carbohydrate metabolism status: normal, prediabetes, unknown diabetes (UNKDM), and known diabetes (KDM). Logistic regression analyses were conducted.Results. Mean PCS-12/MCS-12 values were50.9±8.5/47.6±10.2, respectively. Men had higher scores than women in both PCS-12 (51.8±7.2versus50.3±9.2;P<0.001) and MCS-12 (50.2±8.5versus45.5±10.8;P<0.001). Increasing age and obesity were associated with a poorer PCS-12 score. In women lower PCS-12 and MCS-12 scores were associated with a higher level of glucose metabolism abnormality (prediabetes and diabetes), (P<0.0001for trend), but only the PCS-12 score was associated with altered glucose levels in men (P<0.001for trend). The Odds Ratio adjusted for age, body mass index (BMI) and educational level, for a PCS-12 score below the median was 1.62 (CI 95%: 1.2–2.19;P<0.002) for men with KDM and 1.75 for women with KDM (CI 95%: 1.26–2.43;P<0.001), respectively.Conclusion. Current study indicates that increasing levels of altered carbohydrate metabolism are accompanied by a trend towards decreasing quality of life, mainly in women, in a representative sample of Spanish population.
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- 2012