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778 results on '"Boscarino, Joseph A."'

1. Prescription Opioid Dose Reductions and Potential Adverse Events: a Multi-site Observational Cohort Study in Diverse US Health Systems

Author

Metz, Verena E., Ray, G. Thomas, Palzes, Vanessa, Binswanger, Ingrid, Altschuler, Andrea, Karmali, Ruchir N., Ahmedani, Brian K., Andrade, Susan E., Boscarino, Joseph A., Clark, Robin E., Haller, Irina V., Hechter, Rulin C., Roblin, Douglas W., Sanchez, Katherine, Bailey, Steffani R., McCarty, Dennis, Stephens, Kari A., Rosa, Carmen L., Rubinstein, Andrea L., and Campbell, Cynthia I.

Published
2024
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2. Validity of an Automated Algorithm to Identify Cirrhosis Using Electronic Health Records in Patients with Primary Biliary Cholangitis

Author

Lu, Mei, Bowlus, Christopher L, Lindor, Keith, Rodriguez-Watson, Carla V, Romanelli, Robert J, Haller, Irina V, Anderson, Heather, VanWormer, Jeffrey J, Boscarino, Joseph A, Schmidt, Mark A, Daida, Yihe G, Sahota, Amandeep, Vincent, Jennifer, Li, Jia, Trudeau, Sheri, Rupp, Loralee B, and Gordon, Stuart C

Subjects
Health Services and Systems, Health Sciences, Chronic Liver Disease and Cirrhosis, Liver Disease, Clinical Research, Rare Diseases, Digestive Diseases, Oral and gastrointestinal, Good Health and Well Being, primary biliary cirrhosis, cholangitis, race/gender/ethnicity, gender, ethnicity, decompensated cirrhosis, ursodeoxycholic acid, UCDA, FOLD Investigators, Clinical Sciences, Public Health and Health Services, Epidemiology, Public health
Abstract

BackgroundBiopsy remains the gold standard for determining fibrosis stage in patients with primary biliary cholangitis (PBC), but it is unavailable for most patients. We used data from the 11 US health systems in the FibrOtic Liver Disease Consortium to explore a combination of biochemical markers and electronic health record (EHR)-based diagnosis/procedure codes (DPCs) to identify the presence of cirrhosis in PBC patients.MethodsHistological fibrosis staging data were obtained from liver biopsies. Variables considered for the model included demographics (age, gender, race, ethnicity), total bilirubin, alkaline phosphatase, albumin, aspartate aminotransferase (AST) to platelet ratio index (APRI), Fibrosis 4 (FIB4) index, AST to alanine aminotransferase (ALT) ratio, and >100 DPCs associated with cirrhosis/decompensated cirrhosis, categorized into ten clusters. Using least absolute shrinkage and selection operator regression (LASSO), we derived and validated cutoffs for identifying cirrhosis.ResultsAmong 4328 PBC patients, 1350 (32%) had biopsy data; 121 (9%) were staged F4 (cirrhosis). DPC clusters (including codes related to cirrhosis and hepatocellular carcinoma diagnoses/procedures), Hispanic ethnicity, ALP, AST/ALT ratio, and total bilirubin were retained in the final model (AUROC=0.86 and 0.83 on learning and testing data, respectively); this model with two cutoffs divided patients into three categories (no cirrhosis, indeterminate, and cirrhosis) with specificities of 81.8% (for no cirrhosis) and 80.3% (for cirrhosis). A model excluding DPCs retained ALP, AST/ALT ratio, total bilirubin, Hispanic ethnicity, and gender (AUROC=0.81 and 0.78 on learning and testing data, respectively).ConclusionAn algorithm using laboratory results and DPCs can categorize a majority of PBC patients as cirrhotic or noncirrhotic with high accuracy (with a small remaining group of patients' cirrhosis status indeterminate). In the absence of biopsy data, this EHR-based model can be used to identify cirrhosis in cohorts of PBC patients for research and/or clinical follow-up.

Published
2020

3. Dynamic Risk Prediction of Response to Ursodeoxycholic Acid Among Patients with Primary Biliary Cholangitis in the USA

Author

Li, Jia, Lu, Mei, Zhou, Yueren, Bowlus, Christopher L., Lindor, Keith, Rodriguez-Watson, Carla, Romanelli, Robert J., Haller, Irina V., Anderson, Heather, VanWormer, Jeffrey J., Boscarino, Joseph A., Schmidt, Mark A., Daida, Yihe G., Sahota, Amandeep, Vincent, Jennifer, Wu, Kuan-Han Hank, Trudeau, Sheri, Rupp, Loralee B., Melkonian, Christina, and Gordon, Stuart C.

Published
2022
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5. Utility of learning ratio scores from the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word List Memory Test in distinguishing patterns of cognitive decline in veterans referred for neuropsychological evaluation.

Author

Boscarino, Joseph J., Weitzner, Daniel S., Bailey, Erin K., Kamper, Joel E., and Vanderbleek, Emily N.

Subjects
*ALZHEIMER'S disease, *NEUROPSYCHOLOGICAL tests, *NEUROBEHAVIORAL disorders, *NEURODEGENERATION, *COGNITION disorders
Abstract

Background: The Learning Ratio (LR) is a novel learning score that has shown improved utility over other learning metrics in detecting Alzheimer's disease (AD) across multiple memory tasks. However, its utility on the Consortium to Establish a Registry for Alzheimer's Disease Word List Memory Test (CERAD WLMT), a widely used list learning measure sensitive to decline in neurodegenerative disease, is unknown. The goal of the current study was to determine the utility of LR on the CERAD WLMT in differentiating between diagnostic (MiNCD vs MaNCD) and etiologic groups (VaD vs AD) in a veteran sample. Methods: Raw learning slope (RLS) and LR scores were examined in 168 veterans diagnosed with major neurocognitive disorder (MaNCD), mild neurocognitive disorder (MiNCD), or normal aging following neuropsychological evaluation. Patients with MaNCD were further classified by suspected etiology (i.e. microvascular disease vs AD). Results: Whereas RLS scores were not significantly different between MiNCD and MaNCD, LR scores were significantly different between all diagnostic groups (p's <.05). Those with AD had lower LR scores and RLS scores compared to those with VaD (p's <.05). LR classification accuracy was acceptable for MiNCD (AUC =.76), excellent for MaNCD (AUC =.86) and VaD (AUC =.81), and outstanding for AD (AUC =.91). Optimal cutoff scores for WLMT LR were derived from Youden's index. Conclusion: Results support the use of LR scores over RLS when interpreting the CERAD WLMT and highlight the clinical utility of LR in differentiating between diagnostic groups and identifying suspected etiology. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Validation and extension of the quick dementia rating system (QDRS).

Author

Stewart, Peter V., Tapscott, Brian E., Davis, Beate, Boscarino, Joseph J., Sanders, Keshia, Rodgers, Sarajane E., and Lichtenstein, Maya L.

Subjects
MENTAL status examination, CULTURAL prejudices, MEMORY disorders, DEMENTIA, MEDICAL personnel
Abstract

Informant report dementia severity staging measures, such as the Quick Dementia Rating System (QDRS) offer clinicians useful diagnostic and staging information. These measures also potentially avoid many of the pitfalls inherent in mental status examinations (e.g., cultural bias, educational bias, floor and ceiling effects). We derive cut points for the QDRS and comprehensively examine their classification accuracy in a large, diagnostically heterogeneous, rural, memory disorder clinic sample. Our findings suggest the QDRS may be helpful when used in the context of a comprehensive diagnostic and staging evaluation. When used in isolation, the QDRS is insufficiently accurate for diagnosis and staging of dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Neuropsychological and neuroanatomical underpinnings of the face pareidolia errors on the noise pareidolia test in patients with mild cognitive impairment and dementia due to Lewy bodies.

Author

Alsemari, Ahmad and Boscarino, Joseph J.

Subjects
*LEWY body dementia, *MILD cognitive impairment, *ALZHEIMER'S disease, *FUSIFORM gyrus, *OPTICAL illusions
Abstract

Objective: Prior research on the Noise Pareidolia Test (NPT) has demonstrated its clinical utility in detecting patients with mild cognitive impairment and dementia due to Lewy Body Disease (LBD). However, few studies to date have investigated the neuropsychological factors underlying pareidolia errors on the NPT across the clinical spectrum of LBD. Furthermore, to our knowledge, no research has examined the relationship between cortical thickness using MRI data and NPT subscores. As such, this study sought to explore the neuropsychological and neuroanatomical factors influencing performance on the NPT utilizing the National Alzheimer's Coordinating Center Lewy Body Dementia Module. Methods: Our sample included participants with normal cognition (NC; n = 56), LBD with mild cognitive impairment (LBD-MCI; n = 97), and LBD with dementia (LBD-Dementia; n = 94). Archival data from NACC were retrospectively analyzed for group differences in neuropsychological test scores and cognitive and psychiatric predictors of NPT scores. Clinicoradiological correlates between NPT subscores and a small subsample of the above LBD participants were also examined. Results: Analyses revealed significant differences in NPT scores among groups. Regression analysis demonstrated that dementia severity, attention, and visuospatial processing contributed approximately 24% of NPT performance in LBD groups. Clinicoradiological analysis suggests a potential contribution of the right fusiform gyrus, but not the inferior occipital gyrus, to NPT pareidolia error scores. Conclusions: Our findings highlight the interplay of attention and visuoperceptual functions in complex pareidolia in LBD. Further investigation is needed to refine the utility of NPT scores in clinical settings, including identifying patients at risk for visual illusions and hallucinations. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Factors Associated With Prevalence and Treatment of Primary Biliary Cholangitis in United States Health Systems

Author

Everline, Rene, Daar, Zahra S., Melkonian, Christina, Zhang, Talan, Zhou, Yueren, Wu, Hank, Larkin, Dana, Islam, Nishat, Akkerman, Nonna, Trudeau, Sheri, Kohnhorst, Diane, Shaw, Sally F., Chiu, Vicki, Donald, Judy, Turner, Michelle, Rubenstein, Kevin, Redd, Jacquelyn, Wong, Carmen, Mor, Joanne, Bow, Kathy, Pieper, Lisa E., Anderson, Heather, Tesch, Nathan, Trimble, Solomon, De Los Santos, Mario J., III, Amlin, Tina, Khan, Shamyal, Dunlap, Kevin, Lu, Mei, Li, Jia, Haller, Irina V., Romanelli, Robert J., VanWormer, Jeffrey J., Rodriguez, Carla V., Raebel, Marsha A., Boscarino, Joseph A., Schmidt, Mark A., Daida, Yihe G., Sahota, Amandeep, Vincent, Jennifer, Bowlus, Christopher L., Lindor, Keith, Rupp, Loralee B., and Gordon, Stuart C.

Published
2018
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19. Comparison of ICD-9 Codes for Depression and Alcohol Misuse to Survey Instruments Suggests These Codes Should Be Used with Caution

Author

Boscarino, Joseph A., Moorman, Anne C., Rupp, Loralee B., Zhou, Yueren, Lu, Mei, Teshale, Eyasu H., Gordon, Stuart C., Spradling, Philip R., Schmidt, Mark A., Trinacty, Connie Mah, Zhong, Yuna, Holmberg, Scott D., Holtzman, Deborah, Holmberg, Scott D., Teshale, Eyasu H., Spradling, Philip R., Moorman, Anne C., Xing, Jim, Zhong, Yuna, Gordon, Stuart C., Nerenz, David R., Lu, Mei, Lamerato, Lois, Li, Jia, Rupp, Loralee B., Akkerman, Nonna, Oja-Tebbe, Nancy, Zhang, Talan, Trudeau, Sheri, Zhou, Yueren, Boscarino, Joseph A., Daar, Zahra S., Smith, Robert E., Daida, Yihe G., Trinacty, Connie M., Wong, Carmen P., Schmidt, Mark A., Donald, Judy L., Keast, Erin M., and For the Chronic Hepatitis Cohort Study (CheCS) Investigators

Published
2017
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21. Genetic and Psychosocial Risk Factors Associated with Suicide Among Community Veterans: Implications for Screening, Treatment and Precision Medicine

Author

Boscarino,Joseph A, Adams,Richard E, Urosevich,Thomas G, Hoffman,Stuart N, Kirchner,H Lester, Chu,Xin, Shi,Weixing, Boscarino,Joseph J, Dugan,Ryan J, Withey,Carrie A, Figley,Charles R, Boscarino,Joseph A, Adams,Richard E, Urosevich,Thomas G, Hoffman,Stuart N, Kirchner,H Lester, Chu,Xin, Shi,Weixing, Boscarino,Joseph J, Dugan,Ryan J, Withey,Carrie A, and Figley,Charles R

Abstract

Joseph A Boscarino,1 Richard E Adams,2 Thomas G Urosevich,3 Stuart N Hoffman,4 H Lester Kirchner,1 Xin Chu,5 Weixing Shi,5 Joseph J Boscarino,6 Ryan J Dugan,1 Carrie A Withey,1 Charles R Figley7 1Department Population Health Sciences, Geisinger Clinic, Danville, PA, 17822, USA; 2Department Sociology, Kent State University, Kent, OH, 44242, USA; 3Ophthalmology Service, Geisinger Clinic, Mount Pocono, PA, 18344, USA; 4Department Sleep Medicine, Geisinger Clinic, Danville, PA, 17822, USA; 5Obesity Institute, Geisinger Clinic, Danville, PA, 17822, USA; 6Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, STC 7, Tampa, FL, 33606, USA; 7School of Social Work, Tulane University, New Orleans, LA, 70112, USACorrespondence: Joseph A BoscarinoDepartment Population Health Sciences, Geisinger Clinic, 100 N. Academy Ave., 44-00, Danville, PA, 17822, USATel +1 570-214-9825Email joseph.boscarino@gmail.comIntroduction: Since veteran suicide is a concern and our knowledge of predictive factors is still limited, our objective was to assess risk factors for suicide, including genetic factors, among deployed veterans.Methods: For this study, we surveyed 1730 veterans who were outpatients in a multi-hospital system in Pennsylvania. Altogether, 1041 veterans (60%) provided a DNA sample. The genetic risk variants investigated were within loci previously associated with PTSD and substance misuse, including CRHR1, CHRNA5, RORA, and FKBP5 genetic variations, which were used to calculate a polygenic risk score (range=0– 8, mean=3.6, SD=1.4).Results: Most veterans (56.2%) were deployed to Vietnam while significant numbers were deployed to Iraq, Afghanistan, and other post-Vietnam conflicts. Overall, 95.1% of the veterans were male, their mean age was 56.2 (SD=12), and 95.6% were Caucasian. Among the veterans, 24% had high combat exposure. The prevalence of lifetime suicidal thoughts was 11.3%. Additionally, 5.7% ever developed a suicide plan o

Published
2022

22. Medication use and comorbidities in an increasingly younger osteoarthritis population: an 18-year retrospective open-cohort study

Author

Graham, Jove, primary, Novosat, Tonia, additional, Sun, Haiyan, additional, Piper, Brian J, additional, Boscarino, Joseph A, additional, Kern, Melissa S, additional, Hayduk, Vanessa A, additional, Beck, Craig, additional, Robinson, Rebecca L, additional, Casey, Edward, additional, Hall, Jerry, additional, Dorling, Patricia, additional, and Wright, Eric, additional

Published
2023
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24. Impact of hepatitis C treatment status on risk of Parkinson's disease and secondary parkinsonism in the era of direct‐acting antivirals

Author

Selim, Ranya, primary, Zhou, Yueren, additional, Gordon, Stuart C., additional, Zhang, Talan, additional, Lu, Mei, additional, Daida, Yihe G., additional, Boscarino, Joseph A., additional, Schmidt, Mark A., additional, Trudeau, Sheri, additional, Rupp, Loralee B., additional, and Gonzalez, Humberto C., additional

Published
2023
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26. Serum Biomarkers Indicate Long-term Reduction in Liver Fibrosis in Patients With Sustained Virological Response to Treatment for HCV Infection

Author

Holmberg, Scott D., Teshale, Eyasu H., Spradling, Philip R., Moorman, Anne C., Xu, Fujie, Xing, Jim, Tong, Cindy, Gordon, Stuart C., Nerenz, David R., Lu, Mei, Lamerato, Lois, Li, Jia, Rupp, Loralee B., Akkerman, Nonna, Oja-Tebbe, Nancy, Zhang, Talan, Boscarino, Joseph A., Daar, Zahra S., Smith, Robert E., Vijayadeva, Vinutha, Parker, John V., Schmidt, Mark A., Donald, Judy L., Keast, Erin M., and Trudeau, Sheri

Published
2016
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42. Genetic and Psychosocial Risk Factors Associated with Suicide Among Community Veterans: Implications for Screening, Treatment and Precision Medicine

Author

Boscarino, Joseph A, primary, Adams, Richard E, additional, Urosevich, Thomas G, additional, Hoffman, Stuart N, additional, Kirchner, H Lester, additional, Chu, Xin, additional, Shi, Weixing, additional, Boscarino, Joseph J, additional, Dugan, Ryan J, additional, Withey, Carrie A, additional, and Figley, Charles R, additional

Published
2022
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45. The association between buprenorphine treatment duration and mortality: a multi‐site cohort study of people who discontinued treatment

Author

Glanz, Jason M., primary, Binswanger, Ingrid A., additional, Clarke, Christina L., additional, Nguyen, Anh P., additional, Ford, Morgan A., additional, Ray, G. Thomas, additional, Xu, Stanley, additional, Hechter, Rulin C., additional, Yarborough, Bobbi Jo H., additional, Roblin, Douglas W., additional, Ahmedani, Brian, additional, Boscarino, Joseph A., additional, Andrade, Susan E., additional, Rosa, Carmen L., additional, and Campbell, Cynthia I., additional

Published
2022
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46. Predictors of Current DSM-5 PTSD Diagnosis and Symptom Severity Among Deployed Veterans: Significance of Predisposition, Stress Exposure, and Genetics

Author

Hu,Yirui, Chu,Xin, Urosevich,Thomas G, Hoffman,Stuart N, Kirchner,H Lester, Adams,Richard E, Dugan,Ryan J, Boscarino,Joseph J, Shi,Weixing, Withey,Carrie A, Figley,Charles R, Boscarino,Joseph A, Hu,Yirui, Chu,Xin, Urosevich,Thomas G, Hoffman,Stuart N, Kirchner,H Lester, Adams,Richard E, Dugan,Ryan J, Boscarino,Joseph J, Shi,Weixing, Withey,Carrie A, Figley,Charles R, and Boscarino,Joseph A

Abstract

Yirui Hu,1 Xin Chu,2 Thomas G Urosevich,3 Stuart N Hoffman,4 H Lester Kirchner,1 Richard E Adams,5 Ryan J Dugan,6 Joseph J Boscarino,7 Weixing Shi,2 Carrie A Withey,6 Charles R Figley,8 Joseph A Boscarino6 1Biomedical and Translational Informatics, Geisinger Clinic, Danville, PA, USA; 2Obesity Institute, Geisinger Clinic, Danville, PA, USA; 3Ophthalmology Service, Geisinger Clinic, Mount Pocono, PA, USA; 4Sleep Disorders Center, Geisinger Clinic, Danville, PA, USA; 5Department of Sociology, Kent State University, Kent, OH, USA; 6Department of Population Health Sciences, Geisinger Clinic, Danville, PA, USA; 7Department of Clinical Psychology, William James College, Newton, MA, USA; 8Department of Social Work, Tulane University, New Orleans, LA, USACorrespondence: Joseph A BoscarinoGeisinger Clinic, 100 N. Academy Avenue, 44-00, Danville, PA 17822, USATel +1570-214-9622Email jaboscarino@geisinger.eduBackground: Previously we reported a genetic risk score significantly improved PTSD prediction among a trauma-exposed civilian population. In the current study, we sought to assess this prediction among a trauma-exposed military population.Methods: We examined current PTSD diagnosis and PTSD symptom severity among a random sample of 1042 community-based US military veterans. Main effects and interaction effects were assessed for PTSD genetic risk by trauma exposure using cross-product terms for PTSD x trauma exposures, including combat, lifetime trauma, and adverse childhood exposures. The PTSD risk variants studied were within genetic loci previously associated with PTSD, including CRHR1, CHRNA5, RORA, and FKBP5 genetic variants, which were used to calculate a total PTSD genetic risk score (range=0–8, mean=3.6, SD=1.4).Results: Based on DSM-5 PTSD criteria, 7.1% of veterans (95% CI=5.6–8.8) met criteria for current PTSD. The PTSD genetic risk count was significantly higher among PTSD cases vs non-cases (3.92 vs 3.55, p=0.027). Since the PTSD genetic ri

Published
2020

47. The Compassion Fatigue Scale: Its Use with Social Workers Following Urban Disaster

Author

Adams, Richard E., Figley, Charles R., and Boscarino, Joseph A.

Abstract

Objective: The present study has two goals: to assess the difference between secondary trauma and job burnout and to examine the utility of secondary trauma in predicting psychological distress. Method: The data come from a survey of social workers (N = 236) living in New York City 20 months following the September 11 terrorist attacks on the World Trade Center (WTC). Results: Social workers' involvement in WTC recovery efforts is related to secondary trauma but not burnout. Analyses also reveal that both secondary trauma and burnout are related to psychological distress after controlling for other risk factors. Conclusion: This study supports the importance of compassion fatigue as a risk factor for social workers counseling traumatized clients and its association with psychological problems. (Contains 3 tables.)

Published
2008
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48. Hepatitis C treatment failure is associated with increased risk of hepatocellular carcinoma

Author

Lu, Mei, Li, Jia, Rupp, Loralee B., Holmberg, Scott D., Moorman, Anne C., Spradling, Philip R., Teshale, Eyasu H., Zhou, Yueren, Boscarino, Joseph A., Schmidt, Mark A., Lamerato, Lois E., Trinacty, Connie, Trudeau, Sheri, Gordon, Stuart C., Xing, Jim, Tong, Cindy, Nerenz, David R., Akkerman, Nonna, Oja-Tebbe, Nancy, Zhang, Talan, Daar, Zahra S., Smith, Robert E., Parker, John V., Donald, Judy L., and Keast, Erin M.

Published
2016
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