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12 results on '"Bosca, Federica"'

3. SWCNT–porphyrin nano-hybrids selectively activated by ultrasound: an interesting model for sonodynamic applications

Author

Bosca, Federica, primary, Corazzari, Ingrid, additional, Foglietta, Federica, additional, Canaparo, Roberto, additional, Durando, Gianni, additional, Pastero, Linda, additional, Arpicco, Silvia, additional, Dosio, Franco, additional, Zonari, Daniele, additional, Cravotto, Giancarlo, additional, Tagliapietra, Silvia, additional, Serpe, Loredana, additional, Turci, Francesco, additional, and Barge, Alessandro, additional

Published
2020
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4. CHLOROPHYLLS: FROM EVANTABYPRODUCT TO NATURAL PORPHYRIN SOURCE

Author

Bosca, Federica, Ticona, J. C., Gim��nez, A., Flores, N., Chuqui, R., Barge, A., and Lolli, M. L.

Abstract

English Evanta (Galipea longiflora) is a medicinal specie used as antiparasitic agent by the Tacana Amazonian community. The total alkaloids of this plant have showed interesting results in clinical studies for the treatment of cutaneous Leishmaniasis. During the alkaloids isolation and purification processes, chlorophylls, together with non-useful fractions, are eliminated. Chlorophylls represent an important natural source of porphyrins, which have huge potential applications in many fields (materials, catalysis, nanotechnology, diagnostic and photo- and sono-dynamic therapy). They also possess biological and pharmacological activity (antitumoral, antioxidant and antifungal properties). This work is aimed to isolate, purify and characterize chlorophylls contained in evanta leaves. Italiano L���evanta (Galipea longiflora) �� una specie medicinale utilizzata come agente antiparassitario dalla comunit�� amazzonica tacana. Gli alcaloidi di questa pianta hanno mostrato risultati interessanti negli studi clinici per il trattamento della leishmaniosi cutanea. Durante i processi di isolamento e purificazione degli alcaloidi, le clorofille, insieme alle frazioni non utili, vengono eliminate. Le clorofille potrebbero costituire un'importante fonte naturale di porfirine, le quali hanno potenziali applicazioni in molti campi (materiali, catalisi, nanotecnologie, diagnostica e terapia foto- e sono-dinamica). Posseggono inoltre attivit�� biologica e farmacologica (antitumorali, antiossidanti e antifungini). Questo lavoro �� volto ad isolare, purificare e caratterizzare le clorofille presenti nelle foglie di evanta., JUNCO | Journal of UNiversities and international development COoperation, N. 1 (2017): L���Universit�� e la Cooperazione allo Sviluppo che cambia: il progetto Uni.Coo; il progetto RUSSADE (FED/2013/320-115) e gli Atti del Seminario ���Urban Food Policies���

Published
2017
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5. Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1,2,3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres

Author

Sainas, Stefano, primary, Pippione, Agnese C., additional, Giraudo, Alessandro, additional, Martina, Katia, additional, Bosca, Federica, additional, Rolando, Barbara, additional, Barge, Alessandro, additional, Ducime, Alex, additional, Federico, Antonella, additional, Grossert, Stuart J., additional, White, Robert L., additional, Boschi, Donatella, additional, and Lolli, Marco L., additional

Published
2018
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7. Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1,2,3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres.

Author

Sainas, Stefano, Pippione, Agnese C., Giraudo, Alessandro, Martina, Katia, Bosca, Federica, Rolando, Barbara, Barge, Alessandro, Ducime, Alex, Federico, Antonella, Grossert, Stuart J., White, Robert L., Boschi, Donatella, and Lolli, Marco L.

Subjects
BIOISOSTERES, REGIOSELECTIVITY (Chemistry), ALKYLATION, CARBOXYLIC acids, RING formation (Chemistry)
Abstract

Acidic 4‐hydroxy‐1,2,3‐triazole is a proven bioisostere of acidic functions that has recently been used to replace the acidic moieties of biologically active leads. Straightforward chemical strategies for the synthesis of the three possible N‐alkylated 4‐hydroxy‐1,2,3‐triazole regioisomers have been designed and reported herein, by identifying the optimal conditions under which the alkylation of ethyl 4‐benzyloxy‐1,2,3‐triazolecarboxylate (compound 19) can be regiodirected to the triazole N(b) position and thus produce the only isomer that cannot be obtained via the cycloaddition reaction. Furthermore, an innovative platform for parallel synthesis, called Arachno and which has been patented by the authors' group, has been used to speed up the process, and an NMR study has been carried out to better understand the reactivity of compound 19 towards the N(b) position. A library of benzyloxy protected 4‐hydroxy‐1,2,3‐triazoles has been prepared using the two strategies: regiodirection for the N(b) and N(c) isomers and cycloaddition for the N(a) isomers; the processes are described herein. The three N‐alkylated regioisomer series have been characterized spectroscopically (NMR and MS). The subsequent catalytic hydrogenation of the 4‐benzyloxy protective group on the N‐alkylated‐4‐benzyloxy‐5‐ethoxycarbonyl‐1,2,3‐triazoles provided the corresponding substituted 4‐hydroxy‐1,2,3‐triazoles. [ABSTRACT FROM AUTHOR]

Published
2019
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9. Sonodynamic Activity using Porphyrins-SWCNT

Author

Bosca, Federica, Foglietta, Federica, Turci, Francesco, CALCIO GAUDINO, Emanuela, Mana, S., Dosio, Franco, Canaparo, Roberto, Serpe, Loredana, and Barge, Alessandro

Published
2014

10. Porphyrin-Loaded Pluronic Nanobubbles: A New US-Activated Agent for Future Theranostic Applications

Author

Bosca, Federica, Bielecki, Peter A., Exner, Agata A., and Barge, Alessandro

Abstract

Sonodynamic therapy (SDT) has become a promising noninvasive approach for cancer therapy. The treatment exploits the ability of particular molecules (i.e., porphyrins) to be excited by ultrasound and produce reactive oxygen species (ROS) during their decay process. These reactive species, in turn, result in cell death. To capitalize on the real-time visualization and on-demand delivery of ultrasound contrast agents, this study aims to combine porphyrins with nanobubbles (NBs) to obtain an ultrasound-activated theranostic agent that exploits the SDT activity in vitro. Two porphyrin classes, exposing different hydrophobic side chains, were synthesized. NB size and encapsulation efficiency were markedly dependent on the porphyrin structure. The combination of these porphyrin and NBs resulted in a significant reduction in cell viability upon sonication in pilot studies performed on the LS 174T colorectal cancer cell line.

Published
2024
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