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1. Community Use of Repurposed Drugs Before and During COVID-19 Pandemic in the Netherlands: An Interrupted Time-Series Analysis

Author

Zhou G, de Vos S, Schuiling-Veninga CC, Bos J, Oude Rengerink K, Pasmooij AMG, Mol PG, de Bock GH, and Hak E

Subjects
covid-19, drug utilization, repurposed drug, stringency index, Infectious and parasitic diseases, RC109-216
Abstract

Guiling Zhou,1 Stijn de Vos,1 Catharina CM Schuiling-Veninga,1 Jens Bos,1 Katrien Oude Rengerink,2 Anna Maria Gerdina Pasmooij,2 Peter GM Mol,2,3 Geertruida H de Bock,4 Eelko Hak1 1Unit of Pharmaco-Therapy, -Epidemiology and -Economics (PTEE), Department of Pharmacy, University of Groningen, Groningen, the Netherlands; 2Medicines Evaluation Board, Utrecht, the Netherlands; 3Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; 4Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsCorrespondence: Guiling Zhou, Unit of Pharmaco-Therapy, -Epidemiology and -Economics (PTEE), Department of Pharmacy, University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, the Netherlands, Tel +31 503638707, Fax +31 503632772, Email g.zhou@rug.nlBackground: Repurposing registered drugs could reduce coronavirus disease (COVID-19) burden before novel drugs are authorized. Little is known about how the pandemic and imposed restrictions changed their dispensing. We aimed to investigate the impact of COVID-19 pandemic on repurposed drugs dispensing in the Netherlands.Methods: We performed interrupted time-series study using University of Groningen prescription database IADB.nl to evaluate dispensing trends of 24 repurposed drugs before (2017-February 2020) and after (March 2020– 2021) the pandemic’ start. Primary outcomes were monthly prevalence and incidence rates. An autoregressive integrated moving average model assessed the effect of pandemic and stringency index (measuring strictness of government’s restriction policies).Results: Annual number of IADB.nl population ranged from 919,697 to 952,400. Generally, dispensing of common long-term-used drugs was not significantly affected by pandemic. The prevalence of antibacterials (− 4.20 users per 1000 people), antivirals (− 0.04), corticosteroids (− 1.29), prednisolone (− 1.32), calcium channel blocker (− 0.41), and diuretics (− 1.29) was lower than expected after the pandemic’s start, while the prevalence of ivermectin (0.07), sulfonylureas (0.15), sodium-glucose co-transporter-2 (SGLT2) inhibitor (0.17), and anticoagulants (1.95) was higher than expected. The pandemic was associated with statistically significant decreases in the incidence of antibacterials (− 1.21), corticosteroids (− 0.60), prednisolone (− 0.64) and anticoagulants (− 0.02), and increases in ivermectin (0.02), aggregated antidiabetic drugs (0.13), and SGLT2 inhibitors (0.06). These trends were positively associated with pandemic and negatively associated with stringency index.Conclusion: Dispensing of most drugs was not significantly associated with pandemic and government’s response. Despite some statistically significant disruptions, these were not necessarily clinically relevant due to small absolute differences observed.Keywords: COVID-19, drug utilization, repurposed drug, stringency index

Published
2023

3. PI-02: FOLLOW-UP RESULTS OF A PHASE 2 STUDY ASSESSING THE SAFETY AND EFFICACY OF MITAPIVAT TREATMENT, AN ORAL PYRUVATE KINASE ACTIVATOR, FOR UP TO 60 WEEKS IN SUBJECTS WITH SICKLE CELL DISEASE

Author

VAN DIJK M., RAB M., VAN OIRSCHOT B., BOS J., DERICHS C., RIJNEVELD A., CNOSSEN M., NUR E., BIEMOND B., BARTELS M., JANS J., VAN SOLINGE W., SCHUTGENS R., VAN WIJK R., and VAN BEERS E.

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
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5. Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia.

Author

Bergeman, Auke, Lieve, Krystien, Kallas, Dania, Bos, J, Rosés I Noguer, Ferran, Denjoy, Isabelle, Zorio, Esther, Kammeraad, Janneke, Peltenburg, Puck, Tobert, Katie, Aiba, Takeshi, Atallah, Joseph, Drago, Fabrizio, Batra, Anjan, Brugada, Ramon, Borggrefe, Martin, Clur, Sally-Ann, Cox, Moniek, Davis, Andrew, Dhillon, Santokh, Etheridge, Susan, Fischbach, Peter, Franciosi, Sonia, Haugaa, Kristina, Horie, Minoru, Johnsrude, Christopher, Kane, Austin, Krause, Ulrich, Kwok, Sit-Yee, LaPage, Martin, Ohno, Seiko, Probst, Vincent, Roberts, Jason, Robyns, Tomas, Sacher, Frederic, Semsarian, Christopher, Skinner, Jonathan, Swan, Heikki, Tavacova, Terezia, Tisma-Dupanovic, Svjetlana, Tfelt-Hansen, Jacob, Yap, Sing-Chien, Kannankeril, Prince, Leenhardt, Antoine, Till, Janice, Sanatani, Shubhayan, Tanck, Michael, Ackerman, Michael, Wilde, Arthur, and van der Werf, Christian

Subjects
catecholaminergic polymorphic ventricular tachycardia, sudden cardiac death, ventricular arrhythmias, Female, Humans, Adolescent, Male, Flecainide, Incidence, Cross-Over Studies, Tachycardia, Ventricular, Adrenergic beta-Antagonists, Defibrillators, Implantable, Death, Sudden, Cardiac
Abstract

BACKGROUND: In severely affected patients with catecholaminergic polymorphic ventricular tachycardia, beta-blockers are often insufficiently protective. The purpose of this study was to evaluate whether flecainide is associated with a lower incidence of arrhythmic events (AEs) when added to beta-blockers in a large cohort of patients with catecholaminergic polymorphic ventricular tachycardia. METHODS: From 2 international registries, this multicenter case cross-over study included patients with a clinical or genetic diagnosis of catecholaminergic polymorphic ventricular tachycardia in whom flecainide was added to beta-blocker therapy. The study period was defined as the period in which background therapy (ie, beta-blocker type [beta1-selective or nonselective]), left cardiac sympathetic denervation, and implantable cardioverter defibrillator treatment status, remained unchanged within individual patients and was divided into pre-flecainide and on-flecainide periods. The primary end point was AEs, defined as sudden cardiac death, sudden cardiac arrest, appropriate implantable cardioverter defibrillator shock, and arrhythmic syncope. The association of flecainide with AE rates was assessed using a generalized linear mixed model assuming negative binomial distribution and random effects for patients. RESULTS: A total of 247 patients (123 [50%] females; median age at start of flecainide, 18 years [interquartile range, 14-29]; median flecainide dose, 2.2 mg/kg per day [interquartile range, 1.7-3.1]) were included. At baseline, all patients used a beta-blocker, 70 (28%) had an implantable cardioverter defibrillator, and 21 (9%) had a left cardiac sympathetic denervation. During a median pre-flecainide follow-up of 2.1 years (interquartile range, 0.4-7.2), 41 patients (17%) experienced 58 AEs (annual event rate, 5.6%). During a median on-flecainide follow-up of 2.9 years (interquartile range, 1.0-6.0), 23 patients (9%) experienced 38 AEs (annual event rate, 4.0%). There were significantly fewer AEs after initiation of flecainide (incidence rate ratio, 0.55 [95% CI, 0.38-0.83]; P=0.007). Among patients who were symptomatic before diagnosis or during the pre-flecainide period (n=167), flecainide was associated with significantly fewer AEs (incidence rate ratio, 0.49 [95% CI, 0.31-0.77]; P=0.002). Among patients with ≥1 AE on beta-blocker therapy (n=41), adding flecainide was also associated with significantly fewer AEs (incidence rate ratio, 0.25 [95% CI, 0.14-0.45]; P

Published
2023

6. Neutron scattering sum rules, symmetric exchanges, and helicoidal magnetism in MnSb$_2$O$_6$

Author

Chan, E., Lane, H., Pásztorová, J., Songvilay, M., Johnson, R. D., Downie, R., Bos, J-W. G., Rodriguez-Rivera, J. A., Cheong, S. -W., Ewings, R. A., Qureshi, N., and Stock, C.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract

MnSb$_{2}$O$_{6}$ is based on the noncentrosymmetric $P321$ space group with magnetic Mn$^{2+}$ ($S={5/2}$, $L\approx 0$) spins ordering below $T_{\mathrm{N}}=12$ K in a helicoidal structure. The ground state magnetic structure, expected to be built and originate from 7 Heisenberg exchange constants, has been shown to be coupled to the underlying crystallographic chirality with polar domain switching being reported. We apply neutron spectroscopy to extract these symmetric exchange constants. Given the high complexity of the magnetic exchange network, crystallographic structure and complications fitting linear spin-wave models, we take advantage of multiplexed neutron instrumentation to use the first moment sum rule of neutron scattering to estimate the 7 exchange constants. We then use these parameters to calculate the low-energy spin-waves in the N\'eel state to reproduce the neutron response without strong antisymmetric coupling. Using Green's response functions, the stability of long-wavelength excitations in the context of proposed magnetic structures is then discussed. The results show the presence of strong exchange constants for the chiral exchange pathways and illustrate an underlying coupling between crystallographic and magnetic ``chirality" through predominantely symmetric exchange.

Published
2023
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7. Contributors

Author

Ackerman, Michael J., primary, Adedinsewo, Demilade A., additional, Akbilgic, Oguz, additional, Al-Falahi, Zaidon, additional, Alkhatib, Deya, additional, Alkhouli, Mohamad, additional, Awerbach, Jordan D., additional, Axelrod, David M., additional, Baker, G. Hamilton, additional, Bashir, Mohamad, additional, Bond, Raymond, additional, Bos, J. Martijn, additional, Brisk, Robert, additional, Brown, Sherry-Ann, additional, Butler, Liam, additional, C. Chang, Anthony, additional, Camara, Oscar, additional, Chou, Timothy, additional, Davis, Matthew, additional, Dearani, Joseph A., additional, Dorraki, Mohsen, additional, Doukky, Rami, additional, Druz, Regina, additional, Ehwerhemuepha, Louis, additional, Ernst, Zachary, additional, Feaster, William, additional, Feeny, Albert K., additional, Fernandez-Campos, Beatriz A., additional, Fisher, Michael, additional, Flores, Mona G., additional, Franklin, Wayne J., additional, Frederickson, Abby, additional, Gaffar, Sharib, additional, Gates, Darren, additional, Gearhart, Addison, additional, Gerke, Sara, additional, Gomez, Javier, additional, Goto, Shinichi, additional, Grutter, Giorgia, additional, Hall, E. Kevin, additional, Jacobs, Jeffrey P., additional, Jefferies, John L., additional, Jegatheeswaran, Anusha, additional, Jenkins, Kathy, additional, Jone, Pei-Ni, additional, Kouzehkonan, Vahid Ghodrati, additional, Kumar, S. Ram, additional, Lai, Wyman, additional, Laussen, Peter C., additional, Lei, Howard, additional, Leta, Ruben, additional, Liao, Zhibin, additional, Limon, Alfonso, additional, Lopez-Jimenez, Francisco, additional, Lopuszko, Aleksandra, additional, Maher, Kevin, additional, Marano, Rachel, additional, Mattia, Donald, additional, McEneaney, David, additional, McMahon, Colin J., additional, Mesana, Thierry, additional, Moras, Patrizio, additional, Moreno, Tatiana, additional, Moustafa, Abdel Hakim, additional, Nafee, Tarek, additional, Nag, Nitish, additional, Nahar, Jai, additional, Nguyen, Hoang H., additional, Olajide, Olufemi, additional, Overman, David M., additional, Paul Finn, J., additional, Ramirez, Jessily P., additional, Rayan, David, additional, Recto, Mitch, additional, Reddy, Charitha D., additional, Sengupta, Partho P., additional, Shamavu, Ketemwabi Y., additional, Silversides, Candice K., additional, Soliman, Elsayed Z., additional, St Louis, James D., additional, Sun, Louise Y., additional, Tan, Sven, additional, Tandon, Animesh, additional, Tcheng, James E., additional, Toscano, Alessandra, additional, Tozzi, Alberto Eugenio, additional, Tran, Tu Hao, additional, Trivedi, Bhavya, additional, Tsang, Wendy, additional, Tseng, Andrew S., additional, van den Hengel, Anton, additional, Verjans, Johan W., additional, and Young, Krista, additional

Published
2024
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9. A novel application of Fiber Bragg Grating (FBG) sensors in MPGD

Author

Abbaneo D., Abbas M., Abbrescia M., Abi Akl M., Aboamer O., Acosta D., Ahmad A., Ahmed W., Aleksandrov A., Altieri P., Asawatangtrakuldee C., Aspell P., Assran Y., Awan I., Bally S., Ban Y., Banerjee S., Barashko V., Barria P., Bencze G., Beni N., Benussi L., Bhopatkar V., Bianco S., Bos J., Bouhali O., Braghieri A., Braibant S., Buontempo S., Calabria C., Caponero M., Caputo C., Cassese F., Castaneda A., Cauwenbergh S., Cavallo F.R., Celik A., Choi M., Choi S., Christiansen J., Cimmino A., Colafranceschi S., Colaleo A., Conde Garcia A., Czellar S., Dabrowski M.M., De Lentdecker G., De Oliveira R., de Robertis G., Dildick S., Dorney B., Endroczi G., Errico F., Fenyvesi A., Ferrini M., Ferry S., Furic I., Giacomelli P., Gilmore J., Golovtsov V., Guiducci L., Guilloux F., Gutierrez A., Hadjiiska R.M., Hauser J., Hoepfner K., Hohlmann M., Hoorani H., Iaydjiev P., Jeng Y.G., Kamon T., Karchin P., Korytov A., Krutelyov S., Kumar A., Kim H., Lalli A., Lee J., Lenzi T., Litov L., Loddo F., Madorsky A., Maerschalk T., Maggi M., Magnani A., Mal P.K., Mandal K., Marchioro A., Marinov A., Majumdar N., Merlin J.A., Mitselmakher G., Mohanty A.K., Mohapatra A., Molnar J., Muhammad S., Mukhopadhyay S., Naimuddin M., Nuzzo S., Oliveri E., Pant L.M., Paolucci P., Park I., Passamonti L., Passeggio G., Pavlov B., Philipps B., Piccolo D., Pierluigi D., Postema H., Primavera F., Puig Baranac A., Radi A., Radogna R., Raffone G., Ranieri A., Rashevski G., Riccardi C., Rodozov M., Rodrigues A., Ropelewski L., RoyChowdhury S., Russo A., Ryu G., Ryu M.S., Safonov A., Salva S., Saviano G., Sharma A., Sharma R., Shah A.H., Shopova M., Sturdy J., Sultanov G., Swain S.K., Szillasi Z., Talvitie J., Tatarinov A., Tuuva T., Tytgat M., Valente M., Vai I., Van Stenis M., Venditti R., Verhagen E., Verwilligen P., Vitulo P., Volkov S., Vorobyev A., Wang D., Wang M., Yang U., Yang Y., Yonamine R., Zaganidis N., Zenoni F., and Zhang A.

Subjects
Physics, QC1-999
Abstract

We present a novel application of Fiber Bragg Grating (FBG) sensors in the construction and characterisation of Micro Pattern Gaseous Detector (MPGD), with particular attention to the realisation of the largest triple (Gas electron Multiplier) GEM chambers so far operated, the GE1/1 chambers of the CMS experiment at LHC. The GE1/1 CMS project consists of 144 GEM chambers of about 0.5 m2 active area each, employing three GEM foils per chamber, to be installed in the forward region of the CMS endcap during the long shutdown of LHC in 2108-2019. The large active area of each GE1/1 chamber consists of GEM foils that are mechanically stretched in order to secure their flatness and the consequent uniform performance of the GE1/1 chamber across its whole active surface. So far FBGs have been used in high energy physics mainly as high precision positioning and re-positioning sensors and as low cost, easy to mount, low space consuming temperature sensors. FBGs are also commonly used for very precise strain measurements in material studies. In this work we present a novel use of FBGs as flatness and mechanical tensioning sensors applied to the wide GEM foils of the GE1/1 chambers. A network of FBG sensors have been used to determine the optimal mechanical tension applied and to characterise the mechanical tension that should be applied to the foils. We discuss the results of the test done on a full-sized GE1/1 final prototype, the studies done to fully characterise the GEM material, how this information was used to define a standard assembly procedure and possible future developments.

Published
2018
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10. Quality control for the first large areas of triple-GEM chambers for the CMS endcaps

Author

Abbaneo D., Abbas M., Abbrescia M., Abi Akl M., Aboamer O., Acosta D., Ahmad A., Ahmed W., Aleksandrov A., Altieri P., Asawatangtrakuldee C., Aspell P., Assran Y., Awan I., Bally S., Ban Y., Banerjee S., Barashko V., Barria P., Bencze G., Beni N., Benussi L., Bhopatkar V., Bianco S., Bos J., Bouhali O., Braghieri A., Braibant S., Buontempo S., Calabria C., Caponero M., Caputo C., Cassese F., Castaneda A., Cauwenbergh S., Cavallo F.R., Celik A., Choi M., Choi S., Christiansen J., Cimmino A., Colafranceschi S., Colaleo A., Conde Garcia A., Czellar S., Dabrowski M.M., De Lentdecker G., De Oliveira R., de Robertis G., Dildick S., Dorney B., Endroczi G., Errico F., Fenyvesi A., Ferry S., Furic I., Giacomelli P., Gilmore J., Golovtsov V., Guiducci L., Guilloux F., Gutierrez A., Hadjiiska R.M., Hauser J., Hoepfner K., Hohlmann M., Hoorani H., Iaydjiev P., Jeng Y.G., Kamon T., Karchin P., Korytov A., Krutelyov S., Kumar A., Kim H., Lee J., Lenzi T., Litov L., Loddo F., Madorsky A., Maerschalk T., Maggi M., Magnani A., Mal P.K., Mandal K., Marchioro A., Marinov A., Majumdar N., Merlin J.A., Mitselmakher G., Mohanty A.K., Mohapatra A., Molnar J., Muhammad S., Mukhopadhyay S., Naimuddin M., Nuzzo S., Oliveri E., Pant L.M., Paolucci P., Park I., Passeggio G., Pavlov B., Philipps B., Piccolo D., Postema H., Puig Baranac A., Radi A., Radogna R., Raffone G., Ranieri A., Rashevski G., Riccardi C., Rodozov M., Rodrigues A., Ropelewski L., RoyChowdhury S., Ryu G., Ryu M.S., Safonov A., Salva S., Saviano G., Sharma A., Sharma R., Shah A.H., Shopova M., Sturdy J., Sultanov G., Swain S.K., Szillasi Z., Talvitie J., Tatarinov A., Tuuva T., Tytgat M., Vai I., Van Stenis M., Venditti R., Verhagen E., Verwilligen P., Vitulo P., Volkov S., Vorobyev A., Wang D., Wang M., Yang U., Yang Y., Yonamine R., Zaganidis N., Zenoni F., and Zhang A.

Subjects
Physics, QC1-999
Abstract

The CMS Collaboration plans to equip the very forward muon system with triple-GEM detectors that can withstand the environment of the High-Luminosity LHC. This project is at the final stages of R&D and moving to production. An unprecedented large area of several 100 m2 are to be instrumented with GEM detectors which will be produced in six different sites around the world. A common construction and quality control procedure is required to ensure the performance of each detector. The quality control steps will include optical inspection, cleaning and baking of all materials and parts used to build the detector, leakage current tests of the GEM foils, high voltage tests, gas leak tests of the chambers and monitoring pressure drop vs. time, gain calibration to know the optimal operation region of the detector, gain uniformity tests, and studying the efficiency, noise and tracking performance of the detectors in a cosmic stand using scintillators.

Published
2018
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11. Neutron diffraction in MnSb2O6: Magnetic and structural domains in a helicoidal polar magnet with coupled chiralities

Author

Chan, E., Pásztorová, J., Johnson, R. D., Songvilay, M., Downie, R. A., Bos, J-W. G., Fabelo, O., Ritter, C., Beauvois, K., Niedermayer, Ch., Cheong, S. -W., Qureshi, N., and Stock, C.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract

MnSb$_{2}$O$_{6}$ is based on the structural chiral $P$321 space group #150 where the magnetic Mn$^{2+}$ moments ($S=5/2$, $L\approx 0$) order antiferromagnetically at $T_\mathrm{N}=12$ K. Unlike the related iron based langasite (Ba$_3$NbFe$_3$Si$_2$O$_{14}$) where the low temperature magnetism is based on a proper helix characterized by a time-even pseudoscalar `magnetic' chirality, the Mn$^{2+}$ ions in MnSb$_{2}$O$_{6}$ order with a cycloidal structure at low temperatures, described instead by a time-even vector `magnetic' polarity. A tilted cycloidal structure has been found [M. Kinoshita et al. Phys. Rev. Lett. 117, 047201 (2016)] to facilitate ferroelectric switching under an applied magnetic field. In this work, we apply polarized and unpolarized neutron diffraction analyzing the magnetic and nuclear structures in MnSb$_{2}$O$_{6}$ with the aim of understanding this magnetoelectric coupling. We find no evidence for a helicoidal magnetic structure with one of the spin envelope axes tilted away from the cycloidal $c$-axis. However, on application of a magnetic field $\parallel$ $\vec{c}$ the spin rotation plane can be tilted, giving rise to a cycloid-helix admixture that evolves towards a distorted helix (zero cycloidal component) for fields great than $\approx$ 2 T. We propose a mechanism for the previously reported ferroelectric switching based on coupled structural and magnetic chiralities requiring only an imbalance of structural chiral domains.

Published
2022
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12. Therapeutic Efficacy of Mexiletine for Long QT Syndrome Type 2: Evidence From Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes, Transgenic Rabbits, and Patients

Author

Crotti, Lia, Neves, Raquel, Dagradi, Federica, Musu, Giulia, Giannetti, Federica, Bos, J. Martijn, Barbieri, Miriam, Cerea, Paolo, Giovenzana, Fulvio L.F., Torchio, Margherita, Mura, Manuela, Gnecchi, Massimiliano, Conte, Giulio, Auricchio, Angelo, Sala, Luca, Odening, Katja E., Ackerman, Michael J., and Schwartz, Peter J.

Published
2024
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17. Echocardiographic Diagnosis of Hypertrophic Cardiomyopathy by Machine Learning

Author

Farahani, Nasibeh Zanjirani, Aguirre, Mateo Alzate, Vizentin, Vanessa Karlinski, Enayati, Moein, Bos, J. Martijn, Medina, Andredi Pumarejo, Larson, Kathryn F., Pasupathy, Kalyan S., Scott, Christopher G., Zacher, April, Schlechtinger, Eduard, Daniels, Bruce, Kaggal, Vinod C., Geske, Jeffrey B., Pellikka, Patricia A., Oh, Jae K., Ommen, Steve, Kane, Garvan, Ackerman, Michael J., and Arruda-Olson, Adelaide M.

Published
2024
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20. Trends in mortality in people with HIV from 1999 to 2020: a multi-cohort collaboration

Author

Tusch, E, Ryom, L, Pelchen-Matthews, A, Mocroft, A, Elbirt, D, Oprea, C, Günthard, H, Staehelin, C, Zangerle, R, Suarez, I, Vehreschild, J, Wit, F, Menozzi, M, d'Arminio Monforte, A, Spagnuolo, V, Pradier, C, Carlander, C, Suanzes, P, Wasmuth, J, Carr, A, Petoumenos, K, Borgans, F, Bonnet, F, De Wit, S, El-Sadr, W, Neesgaard, B, Jaschinski, N, Greenberg, L, Hosein, S, Gallant, J, Vannappagari, V, Young, L, Sabin, C, Lundgren, J, Peters, L, Reekie, J, Calvo, G, Dabis, F, Kirk, O, Law, M, Monforte, A, Morfeldt, L, Reiss, P, Weber, R, Lind-Thomsen, A, Brandt, R, Hillebreght, M, Zaheri, S, Scherrer, A, Schöni-Affolter, F, Rickenbach, M, Tavelli, A, Fanti, I, Leleux, O, Mourali, J, Marec, F, Boerg, E, Thulin, E, Sundström, A, Bartsch, G, Thompsen, G, Necsoi, C, Delforge, M, Fontas, E, Caissotti, C, Dollet, K, Mateu, S, Torres, F, Blance, A, Huang, R, Puhr, R, Laut, K, Kristensen, D, Phillips, A, Kamara, D, Smith, C, Hatleberg, C, Raben, D, Matthews, C, Bojesen, A, Grevsen, A, Powderly, B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Smit, C, Ross, M, Fux, C, Morlat, P, Friis-Møller, N, Kowalska, J, Bohlius, J, Bower, M, Fätkenheuer, G, Grulich, A, Sjøl, A, Meidahl, P, Iversen, J, Reiss, C, Hillebregt, M, Prins, J, Kuijpers, T, Scherpbier, H, van der Meer, J, Godfried, M, van der Poll, T, Nellen, F, Geerlings, S, van Vugt, M, Pajkrt, D, Bos, J, Wiersinga, W, van der Valk, M, Goorhuis, A, Hovius, J, van Eden, J, Henderiks, A, van Hes, A, Mutschelknauss, M, Nobel, H, Pijnappel, F, Jurriaans, S, Back, N, Zaaijer, H, Berkhout, B, Cornelissen, M, Schinkel, C, Thomas, X, Ziekenhuis, A, van den Berge, M, Stegeman, A, Baas, S, de Looff, L, Versteeg, D, Ziekenhuis, C, Pronk, M, Ammerlaan, H, De Munnik, E, Jansz, A, Tjhie, J, Wegdam, M, Deiman, B, Scharnhorst, V, van der Plas, A, Weijsenfeld, A, van der Ende, M, De Vries-Sluijs, T, van Gorp, E, Schurink, C, Nouwen, J, Verbon, A, Rijnders, B, Bax, H, van der Feltz, M, Bassant, N, van Beek, J, Vriesde, M, van Zonneveld, L, de Oude-Lubbers, A, van den Berg-Cameron, H, Bruinsma-Broekman, F, de Groot, J, de Man, M, Boucher, C, Koopmans, M, van Kampen, J, Pas, S, Mc–sophia, E, Driessen, G, van Rossum, A, van der Knaap, L, Visser, E, Branger, J, Rijkeboer-Mes, A, de Ven, C, Ziekenhuis, H, Schippers, E, van Nieuwkoop, C, van IJperen, J, Geilings, J, van der Hut, G, Franck, P, van Eeden, A, Brokking, W, Groot, M, Elsenburg, L, Damen, M, Kwa, I, Groeneveld, P, Bouwhuis, J, van den Berg, J, van Hulzen, A, van der Bliek, G, Bor, P, Bloembergen, P, Wolfhagen, M, Ruijs, G, Kroon, F, de Boer, M, Bauer, M, Jolink, H, Vollaard, A, Dorama, W, van Holten, N, Claas, E, Wessels, E, den Hollander, J, Pogany, K, Roukens, A, Kastelijns, M, Smit, J, Smit, E, Struik-Kalkman, D, Tearno, C, Bezemer, M, van Niekerk, T, Pontesilli, O, Lowe, S, Lashof, A, Posthouwer, D, Ackens, R, Schippers, J, Vergoossen, R, Weijenberg-Maes, B, van Loo, I, Havenith, T, Leyten, E, Gelinck, L, van Hartingsveld, A, Meerkerk, C, Wildenbeest, G, 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Wildenbeest, G S, Mutsaers, J A E M, Jansen, C L, Mulder, J W, Vrouenraets, S M E, Lauw, F N, van Broekhuizen, M C, Vlasblom, D J, Smits, P H M, Zuiderzee, M C, Bosma, A S, van Vonderen, M G A, van Houte, D P F, Kampschreur, L M, Kootstra, G J, Delsing, C E, Stuart, J W T Cohen, Diederen, B M W, van Truijen-Oud, F A, van der Reijden, W A, van den Berk, G E L, Blok, W L, Frissen, P H J, Lettinga, K D, Schouten, W E M, Brouwer, C J, Geerders, G F, Kleene, M J, van der Meché, I B, Toonen, A J M, Koopmans, P P, van der Ven, A J A M, ter Hofstede, H J M, Dofferhoff, A S M, Bosch, M E W, Grintjes-Huisman, K J T, Zomer, B J, Stelma, F F, Gisolf, E H, Hassing, R J, van Bentum, P H M, Swanink, C M A, van Lelyveld, S F L, van der Prijt, L M M, Herpers, B L, Verhagen, D W M, Ziekenhuis, St Elisabeth, van Kasteren, M E E, Brouwer, A E, de Wiel, B A F M de Kruijf-van, Santegoets, R M W J, Marcelis, J H, Buiting, A G M, Kabel, P J, Bierman, W F W, Wilting, K R, Jonge, H de Groot-de, van der Meulen, P A, de Weerd, D A, Niesters, H G M, van Leer-Buter, C C, Hoepelman, A I M, Ellerbroek, P M, Oosterheert, J J, Arends, J E, Barth, R E, Wassenberg, M W M, Schadd, E M, van Elst-Laurijssen, D H M, van Oers-Hazelzet, E E B, Wensing, A M J, Peters, E J G, van Agtmael, M A, Laan, L M, Pettersson, A M, Vandenbroucke-Grauls, C M J E, Ang, C W, Kinderziekenhuis, Wilhelmina, Geelen, S P M, Wolfs, T F W, Bont, L J, Bezemer, D O, van Sighem, A I, Boender, T S, Rademaker, M J, Pellegrin, J L, Vareil, M O, Dauchy, F A, Receveur, M C, Vandenhende, M A, Viallard, J F, Lafon, Me, Blaizeau, M J, Boerg, Eloïse, Law, Central M, Calvo, Central G, Sambeat, M A, Gennotte, A F, Payen, M C, Neaton, Central J, El-Sadr, W M, Abrams, D I, Crane, L R, Fischer, A H, Larsen, J F, Wien, Pulmologisches Zentrum der Stadt, Mitsura, V M, Møller, N F, Nielsen, L N, Smidt, Jelena, Siseklinik, Nakkusosakond, Viard, J-P, Stellbrink, H J, Goethe, J W, Sthoeger, Z M, Monforte, A D’Arminio, Annunziata, Ospedale S Maria, Blokhina, I N, Novogrod, Nizhny, Gatell, J M, Miró, J M, Rodriguez, J M, Laporte, J M, Johnson, A M, Johnson, M A, Morfeldt, Central L, Perri, G Di, Marchetti, G C, Perno, C F, Caputo, S Lo, Capobianchi, M R, Biagio, A Di, Roldan, E Quiros, Santoro, M M, Caro, A Di, Manconi, P E, Moioli, M C, Ridolfo, A L, Martino, F Di, Cattelan, A M, Ursitti, M A, Sulekova, L Fontanelli, Plazzi, M M, Del Vecchio, R Fontana, Giuli, C Di, Orofino, G C, Roger, P M, Braun, D L, Bucher, H C, Günthard, H F, Hirsch, H H, Kouyos, R D, de Tejada, B Martinez, Metzner, K J, Scherrer, A U, Valk, Marc vd, Han, W Min, Saint-Pierre, C H U, Miro, J M, Wasmuth, J C, Vehreschild, J J, McNicholl, I, Williams, E D, Volny-Anne, R Campo Alain, Dedes, Nikos, Mendão, Luis, Jakobsen, M L, Kumar, L Ramesh, Elsing, T W, and null, null

Abstract

Background: Mortality among people with HIV declined with the introduction of combination antiretroviral therapy. We investigated trends over time in all-cause and cause-specific mortality in people with HIV from 1999-2020. Methods: Data were collected from the D:A:D cohort from 1999 through January 2015 and RESPOND from October 2017 through 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV (CoDe), were calculated. Poisson regression models were used to assess mortality trends over time. Results: Among 55716 participants followed for a median of 6 years (IQR 3-11), 5263 participants died (crude mortality rate [MR] 13.7/1000 PYFU; 95%CI 13.4-14.1). Changing patterns of mortality were observed with AIDS as the most common cause of death between 1999- 2009 (n = 952, MR 4.2/1000 PYFU; 95%CI 4.0-4.5) and non-AIDS defining malignancy (NADM) from 2010 -2020 (n = 444, MR 2.8/1000 PYFU; 95%CI 2.5-3.1). In multivariable analysis, all-cause mortality declined over time (adjusted mortality rate ratio [aMRR] 0.97 per year; 95%CI 0.96, 0.98), mostly from 1999 through 2010 (aMRR 0.96 per year; 95%CI 0.95-0.97), and with no decline shown from 2011 through 2020 (aMRR 1·00 per year; 95%CI 0·96-1·05). Mortality due all known causes except NADM also declined over the entire follow-up period. Conclusion: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts decreased between 1999 and 2009 and was stable over the period from 2010 through 2020. The decline in mortality rates was not fully explained by improvements in immunologic-virologic status or other risk factors.

Published
2024

25. Genotype Predicts Outcomes in Fetuses and Neonates With Severe Congenital Long QT Syndrome

Author

Moore, Jeremy P, Gallotti, Roberto G, Shannon, Kevin M, Bos, J Martijn, Sadeghi, Elham, Strasburger, Janette F, Wakai, Ronald T, Horigome, Hitoshi, Clur, Sally-Ann, Hill, Allison C, Shah, Maully J, Behere, Shashank, Sarquella-Brugada, Georgia, Czosek, Richard, Etheridge, Susan P, Fischbach, Peter, Kannankeril, Prince J, Motonaga, Kara, Landstrom, Andrew P, Williams, Matthew, Patel, Akash, Dagradi, Federica, Tan, Reina B, Stephenson, Elizabeth, Krishna, Mani Ram, Miyake, Christina Y, Lee, Michelle E, Sanatani, Shubhayan, Balaji, Seshadri, Young, Ming-Lon, Siddiqui, Saad, Schwartz, Peter J, Shivkumar, Kalyanam, and Ackerman, Michael J

Subjects
Genetics, Cardiovascular, Pediatric, Infant Mortality, Clinical Research, Heart Disease, Perinatal Period - Conditions Originating in Perinatal Period, Aftercare, Electrocardiography, Fetus, Genotype, Humans, Infant, Newborn, Long QT Syndrome, Patient Discharge, Retrospective Studies, atrioventricular block, cardiac sympathetic denervation, fetal arrhythmia, fetus, genetic testing, implantable cardioverter-defibrillator, long QT syndrome, magnetocardiography, sudden cardiac death, torsades de pointes, Cardiorespiratory Medicine and Haematology, Clinical Sciences
Abstract

ObjectivesThis study sought to determine the relationship between long QT syndrome (LQTS) subtype (LTQ1, LTQ2, LTQ3) and postnatal cardiac events (CEs).BackgroundLQTS presenting with 2:1 atrioventricular block or torsades de pointes in the fetus and/or neonate has been associated with risk for major CEs, but overall outcomes and predictors remain unknown.MethodsA retrospective study involving 25 international centers evaluated the course of fetuses/newborns diagnosed with congenital LQTS and either 2:1 atrioventricular block or torsades de pointes. The primary outcomes were age at first CE after dismissal from the newborn hospitalization and death and/or cardiac transplantation during follow-up. CE was defined as aborted cardiac arrest, appropriate shock from implantable cardioverter-defibrillator, or sudden cardiac death.ResultsA total of 84 fetuses and/or neonates were identified with LQTS (12 as LQT1, 35 as LQT2, 37 as LQT3). Median gestational age at delivery was 37 weeks (interquartile range: 35 to 39 weeks) and age at hospital discharge was 3 weeks (interquartile range: 2 to 5 weeks). Fetal demise occurred in 2 and pre-discharge death in 1. Over a median of 5.2 years, there were 1 LQT1, 3 LQT2, and 23 LQT3 CEs (13 aborted cardiac arrests, 5 sudden cardiac deaths, and 9 appropriate shocks). One patient with LQT1 and 11 patients with LQT3 died or received cardiac transplant during follow-up. The only multivariate predictor of post-discharge CEs was LQT3 status (LQT3 vs. LQT2: hazard ratio: 8.4; 95% confidence interval: 2.6 to 38.9; p

Published
2020

28. An International Multicenter Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2-Catecholaminergic Polymorphic Ventricular Tachycardia

Author

Ng, Kevin, Titus, Erron W, Lieve, Krystien V, Roston, Thomas M, Mazzanti, Andrea, Deiter, Frederick H, Denjoy, Isabelle, Ingles, Jodie, Till, Jan, Robyns, Tomas, Connors, Sean P, Steinberg, Christian, Abrams, Dominic J, Pang, Benjamin, Scheinman, Melvin M, Bos, J Martijn, Duffett, Stephen A, van der Werf, Christian, Maltret, Alice, Green, Martin S, Rutberg, Julie, Balaji, Seshadri, Cadrin-Tourigny, Julia, Orland, Kate M, Knight, Linda M, Brateng, Caitlin, Wu, Jeremy, Tang, Anthony S, Skanes, Allan C, Manlucu, Jaimie, Healey, Jeff S, January, Craig T, Krahn, Andrew D, Collins, Kathryn K, Maginot, Kathleen R, Fischbach, Peter, Etheridge, Susan P, Eckhardt, Lee L, Hamilton, Robert M, Ackerman, Michael J, Noguer, Ferran Rosés I, Semsarian, Christopher, Jura, Natalia, Leenhardt, Antoine, Gollob, Michael H, Priori, Silvia G, Sanatani, Shubhayan, Wilde, Arthur AM, Deo, Rahul C, and Roberts, Jason D

Subjects
Clinical Research, Cardiovascular, Genetics, Heart Disease, Aetiology, 2.1 Biological and endogenous factors, Calsequestrin, Female, Heterozygote, Homozygote, Humans, Male, Mutation, Missense, Risk Factors, Tachycardia, Ventricular, arrhythmias, cardiac, catecholaminergic polymorphic ventricular tachycardia, death, sudden, genetics, arrhythmias, cardiac, death, sudden, cardiac, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

BackgroundGenetic variants in calsequestrin-2 (CASQ2) cause an autosomal recessive form of catecholaminergic polymorphic ventricular tachycardia (CPVT), although isolated reports have identified arrhythmic phenotypes among heterozygotes. Improved insight into the inheritance patterns, arrhythmic risks, and molecular mechanisms of CASQ2-CPVT was sought through an international multicenter collaboration.MethodsGenotype-phenotype segregation in CASQ2-CPVT families was assessed, and the impact of genotype on arrhythmic risk was evaluated using Cox regression models. Putative dominant CASQ2 missense variants and the established recessive CASQ2-p.R33Q variant were evaluated using oligomerization assays and their locations mapped to a recent CASQ2 filament structure.ResultsA total of 112 individuals, including 36 CPVT probands (24 homozygotes/compound heterozygotes and 12 heterozygotes) and 76 family members possessing at least 1 presumed pathogenic CASQ2 variant, were identified. Among CASQ2 homozygotes and compound heterozygotes, clinical penetrance was 97.1% and 26 of 34 (76.5%) individuals had experienced a potentially fatal arrhythmic event with a median age of onset of 7 years (95% CI, 6-11). Fifty-one of 66 CASQ2 heterozygous family members had undergone clinical evaluation, and 17 of 51 (33.3%) met diagnostic criteria for CPVT. Relative to CASQ2 heterozygotes, CASQ2 homozygote/compound heterozygote genotype status in probands was associated with a 3.2-fold (95% CI, 1.3-8.0; P=0.013) increased hazard of a composite of cardiac syncope, aborted cardiac arrest, and sudden cardiac death, but a 38.8-fold (95% CI, 5.6-269.1; P

Published
2020

29. An International Multicenter Evaluation of Type 5 Long QT Syndrome

Author

Roberts, Jason D, Asaki, S Yukiko, Mazzanti, Andrea, Bos, J Martijn, Tuleta, Izabela, Muir, Alison R, Crotti, Lia, Krahn, Andrew D, Kutyifa, Valentina, Shoemaker, M Benjamin, Johnsrude, Christopher L, Aiba, Takeshi, Marcondes, Luciana, Baban, Anwar, Udupa, Sharmila, Dechert, Brynn, Fischbach, Peter, Knight, Linda M, Vittinghoff, Eric, Kukavica, Deni, Stallmeyer, Birgit, Giudicessi, John R, Spazzolini, Carla, Shimamoto, Keiko, Tadros, Rafik, Cadrin-Tourigny, Julia, Duff, Henry J, Simpson, Christopher S, Roston, Thomas M, Wijeyeratne, Yanushi D, El Hajjaji, Imane, Yousif, Maisoon D, Gula, Lorne J, Leong-Sit, Peter, Chavali, Nikhil, Landstrom, Andrew P, Marcus, Gregory M, Dittmann, Sven, Wilde, Arthur AM, Behr, Elijah R, Tfelt-Hansen, Jacob, Scheinman, Melvin M, Perez, Marco V, Kaski, Juan Pablo, Gow, Robert M, Drago, Fabrizio, Aziz, Peter F, Abrams, Dominic J, Gollob, Michael H, Skinner, Jonathan R, Shimizu, Wataru, Kaufman, Elizabeth S, Roden, Dan M, Zareba, Wojciech, Schwartz, Peter J, Schulze-Bahr, Eric, Etheridge, Susan P, Priori, Silvia G, and Ackerman, Michael J

Subjects
Genetics, Cardiovascular, Clinical Trials and Supportive Activities, Heart Disease, Clinical Research, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Adolescent, Adult, Death, Sudden, Cardiac, Electric Countershock, Electrocardiography, Female, Heart Arrest, Humans, Long QT Syndrome, Male, Middle Aged, Penetrance, Potassium Channels, Voltage-Gated, Registries, arrhythmia, genetics, long QT syndrome, penetrance, sudden cardiac death, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

BackgroundInsight into type 5 long QT syndrome (LQT5) has been limited to case reports and small family series. Improved understanding of the clinical phenotype and genetic features associated with rare KCNE1 variants implicated in LQT5 was sought through an international multicenter collaboration.MethodsPatients with either presumed autosomal dominant LQT5 (N = 229) or the recessive Type 2 Jervell and Lange-Nielsen syndrome (N = 19) were enrolled from 22 genetic arrhythmia clinics and 4 registries from 9 countries. KCNE1 variants were evaluated for ECG penetrance (defined as QTc >460 ms on presenting ECG) and genotype-phenotype segregation. Multivariable Cox regression was used to compare the associations between clinical and genetic variables with a composite primary outcome of definite arrhythmic events, including appropriate implantable cardioverter-defibrillator shocks, aborted cardiac arrest, and sudden cardiac death.ResultsA total of 32 distinct KCNE1 rare variants were identified in 89 probands and 140 genotype positive family members with presumed LQT5 and an additional 19 Type 2 Jervell and Lange-Nielsen syndrome patients. Among presumed LQT5 patients, the mean QTc on presenting ECG was significantly longer in probands (476.9±38.6 ms) compared with genotype positive family members (441.8±30.9 ms, P

Published
2020

30. Histone Modifications and miRNA Perturbations Contribute to Transcriptional Dysregulation of Hypertrophy in Obstructive Hypertrophic Cardiomyopathy

Author

Garmany, Ramin, primary, Dasari, Surendra, additional, Bos, J. Martjn, additional, Kim, Evelyn T, additional, Tester, David J, additional, dos Remedios, Cristobal, additional, Maleszewski, Joseph J, additional, Robertson, Keith D, additional, Dearani, Joseph A, additional, Ommen, Steve R, additional, Giudicessi, John R, additional, and Ackerman, Michael J, additional

Published
2024
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32. Incidence of Newly Recognized Atrial Fibrillation in Patients with Obstructive Hypertrophic Cardiomyopathy Treated with Mavacamten

Author

Castrichini, Matteo, primary, Alsidawi, Said, additional, Geske, Jeffrey B., additional, Newman, Darrell B., additional, Arruda-Olson, Adelaide M., additional, Bos, J. Martijn, additional, Ommen, Steve R., additional, Siontis, Konstantinos C., additional, Ackerman, Michael J., additional, and Giudicessi, John R., additional

Published
2024
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33. Critical mode and band-gap-controlled bipolar thermoelectric properties of SnSe

Author

Loa, I., Popuri, S. R., Fortes, A. D., and Bos, J. W. G.

Subjects
Condensed Matter - Materials Science
Abstract

The reliable calculation of electronic structures and understanding of electrical properties depends on an accurate model of the crystal structure. Here, we have reinvestigated the crystal structure of the high-zT thermoelectric material tin selenide, SnSe, between 4 and 1000 K using high-resolution neutron powder diffraction. Symmetry analysis reveals the presence of four active structural distortion modes, one of which is found to be active over a relatively wide range of more than +/-200 K around the symmetry-breaking Pnma-Cmcm transition at 800 K. Density functional theory calculations on the basis of the experimental structure parameters show that the unusual, step-like temperature dependencies of the electrical transport properties of SnSe are caused by the onset of intrinsic bipolar conductivity, amplified and shifted to lower temperatures by a rapid reduction of the band gap between 700 and 800 K. The calculated band gap is highly sensitive to small out-of-plane Sn displacements observed in the diffraction experiments. SnSe with a sufficiently controlled acceptor concentration is predicted to produce simultaneously a large positive and a large negative Seebeck effect along different crystal directions., Comment: 7 pages, 7 figures, accepted for publication in Phys. Rev. Materials

Published
2018
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40. Evidence for hard and soft substructures in thermoelectric SnSe

Author

Popuri, S. R., Pollet, M., Decourt, R., Viciu, M. L., and Bos, J. W. G.

Subjects
Condensed Matter - Materials Science
Abstract

SnSe is a topical thermoelectric material with a low thermal conductivity which is linked to its unique crystal structure. We use low-temperature heat capacity measurements to demonstrate the presence of two characteristic vibrational energy scales in SnSe with Debye temperatures thetaD1 = 345(9) K and thetaD2 = 154(2) K. These hard and soft substructures are quantitatively linked to the strong and weak Sn-Se bonds in the crystal structure. The heat capacity model predicts the temperature evolution of the unit cell volume, confirming that this two-substructure model captures the basic thermal properties. Comparison with phonon calculations reveals that the soft substructure is associated with the low energy phonon modes that are responsible for the thermal transport. This suggests that searching for materials containing highly divergent bond distances should be a fruitful route for discovering low thermal conductivity materials., Comment: Accepted by Applied Physics Letters

Published
2017
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41. Starting Strong: A Randomized Controlled Trial of the Building Assets Reducing Risks (BARR) Model in 9th Grade

Author

Society for Research on Educational Effectiveness (SREE), Hinojosa, T., Bos, J., O'Brien, B., Park, S., Liu, F., and Jerabek, A.

Abstract

Students beginning high school commonly experience increased stress and behavior problems alongside declines in grades, attendance, interest in school, and perceptions of academic competence and self-esteem (Alvidrez & Weinstein, 1993; Reyes et al., 2000). Moreover, research indicates that, relative to students who graduate from high school, those who leave school prematurely are more likely to have experienced deeper 9th grade declines (Reyes et al., 2000; Roderick, 1995). Research also demonstrates positive school climates, positive relationships between students and staff, and among staff, are essential ingredients for turning around low performing schools (Gordon, 2006; National Research Council, 2004; Cohen, 2006; Jerald, 2006; De La Ossa, 2005). More specifically, research is growing on the effectiveness of student-teacher relationships in producing increased attendance and academic performance, and decreased behavior problems. For example, Allen, Pianta, Gregory, Mikami, and Lun (2011) conducted a randomized controlled trial (RCT) in which secondary school teachers were given a year of coaching on effective teaching and student-teacher interactions. After a year of training, students with teachers in the experimental group scored significantly higher on year-end achievement tests than did students in the control group. Quality of student-teacher interaction was a significant mediator of student achievement. With core components derived from research, the Building Assets Reducing Risks (BARR) model© targets students at this critical juncture in their academic career--9th grade. BARR addresses developmental, academic, and structural challenges in the 9th grade by combining student asset building, teachers' real-time analysis of student data, and intensive teacher collaboration to prevent course failure. BARR develops positive student-teacher relationships and integrates student supports into a school's existing model for addressing nonacademic barriers to learning. With funding from the Investing in Innovation program, BARR has been rigorously studied using an RCT and is now under scientific investigation in schools of varying locales and geographic regions to better understand the broader context under which BARR impacts students transitioning to the 9th grade. This current study is a multisite randomized controlled trial that explores replication of BARR across three cohorts of schools. Results from the first RCT demonstrated positive impact on 9th grade students' standardized test scores, credits earned, and overall failure rate. Tables are appended.

Published
2016

43. A Multi-Omics Atlas of Sex-Specific Differences in Obstructive Hypertrophic Cardiomyopathy

Author

Garmany, Ramin, primary, Dasari, Surendra, additional, Bos, J. Martijn, additional, Kim, Evelyn T., additional, Martinez, Katherine A., additional, Tester, David J., additional, Remedios, Cristobal dos, additional, Maleszewski, Joseph J., additional, Dearani, Joseph A., additional, Ommen, Steve R., additional, Geske, Jeffrey B., additional, Giudicessi, John R., additional, and Ackerman, Michael J., additional

Published
2024
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45. Prognostic Value of Multiplexed Assays of Variant Effect and Automated Patch-clamping forKCNH2-LQTS Risk Stratification

Author

O’Neill, Matthew J., primary, Ng, Chai-Ann, additional, Aizawa, Takanori, additional, Sala, Luca, additional, Bains, Sahej, additional, Denjoy, Isabelle, additional, Winbo, Annika, additional, Ullah, Rizwan, additional, Shen, Qianyi, additional, Tan, Chek-Ying, additional, Kozek, Krystian, additional, Vanags, Loren R., additional, Mitchell, Devyn W., additional, Shen, Alex, additional, Wada, Yuko, additional, Kashiwa, Asami, additional, Crotti, Lia, additional, Dagradi, Federica, additional, Musu, Giulia, additional, Spazzolini, Carla, additional, Neves, Raquel, additional, Bos, J. Martijn, additional, Giudicessi, John R., additional, Bledsoe, Xavier, additional, Lancaster, Megan, additional, Glazer, Andrew M., additional, Roden, Dan M., additional, Leenhardt, Antoine, additional, Salem, Joe-Elie, additional, Earle, Nikki, additional, Stiles, Rachael, additional, Agee, Taylor, additional, Johnson, Christopher N., additional, Horie, Minoru, additional, Skinner, Jonathan, additional, Extramiana, Fabrice, additional, Ackerman, Michael J., additional, Schwartz, Peter J., additional, Ohno, Seiko, additional, Vandenberg, Jamie I., additional, and Kroncke, Brett M., additional

Published
2024
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49. Atomic Ordering in Cubic Bismuth Telluride Alloy Phases at High Pressure

Author

Loa, I., Bos, J. -W. G., Downie, R. A., and Syassen, K.

Subjects
Condensed Matter - Materials Science
Abstract

Pressure-induced transitions from ordered intermetallic phases to substitutional alloys to semi-ordered phases were studied in a series of bismuth tellurides. Using angle-dispersive x-ray diffraction, the compounds Bi4Te5, BiTe, and Bi2Te were observed to form alloys with the disordered body-centered cubic (bcc) crystal structure upon compression to above 14--19 GPa at room temperature. The BiTe and Bi2Te alloys and the previously discovered high-pressure alloys of Bi2Te3 and Bi4Te3 were all found to show atomic ordering after gentle annealing at very moderate temperatures of ~100{\deg}C. Upon annealing, BiTe transforms from the bcc to the B2 (CsCl) crystal structure type, and the other phases adopt semi-disordered variants thereof, featuring substitutional disorder on one of the two crystallographic sites. The transition pressures and atomic volumes of the alloy phases show systematic variations across the Bi_mTe_n series including the end members Bi and Te. First-principles calculations were performed to characterize the electronic structure and chemical bonding properties of B2-type BiTe and to identify the driving forces of the ordering transition. The calculated Fermi surface of B2-type BiTe has an intricate structure and is predicted to undergo three topological changes between 20 and 60 GPa., Comment: 8 pages, 11 figures, accepted for publication in Phys. Rev. B

Published
2016
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50. Fiber Bragg Grating (FBG) sensors as flatness and mechanical stretching sensors

Author

Abbaneo, D., Abbas, M., Abbrescia, M., Abdelalim, A. A., Akl, M. Abi, Aboamer, O., Acosta, D., Ahmad, A., Ahmed, W., Aleksandrov, A., Aly, R., Altieri, P., Asawatangtrakuldee, C., Aspell, P., Assran, Y., Awan, I., Bally, S., Ban, Y., Banerjee, S., Barashko, V., Barria, P., Bencze, G., Beni, N., Benussi, L., Bhopatkar, V., Bianco, S., Bos, J., Bouhali, O., Braghieri, A., Braibant, S., Buontempo, S., Calabria, C., Caponero, M., Caputo, C., Cassese, F., Castaneda, A., Cauwenbergh, S., Cavallo, F. R., Celik, A., Choi, M., Choi, S., Christiansen, J., Cimmino, A., Colafranceschi, S., Colaleo, A., Garcia, A. Conde, Czellar, S., Dabrowski, M. M., De Lentdecker, G., De Oliveira, R., de Robertis, G., Dildick, S., Dorney, B., Elmetenawee, W., Endroczi, G., Errico, F., Fenyvesi, A., Ferry, S., Furic, I., Giacomelli, P., Golovtsov, V., Guiducci, L., Guilloux, F., Gutierrez, A., Hadjiiska, R. M., Hassan, A., Hauser, J., Hoepfner, K., Hohlmann, M., Hoorani, H., Iaydjiev, P., Jeng, Y. G., Kamon, T., Karchin, P., Korytov, A., Krutelyov, S., Kumar, A., Kim, H., Lee, J., Lenzi, T., Litov, L., Loddo, F., Madorsky, A., Maerschalk, T., Maggi, M., Magnani, A., Mal, P. K., Mandal, K., Marchioro, A., Marinov, A., Masod, R., Majumdar, N., Merlin, J. A., Mitselmakher, G., Mohanty, A. K., Muhammad, S., Mohapatra, A., Molnar, J., Mukhopadhyay, S., Naimuddin, M., Nuzzo, S., Oliveri, E., Pant, L. M., Paolucci, P., Park, I., Passeggio, G., Passamonti, L., Pavlov, B., Philipps, B., Piccolo, D., Pierluigi, D., Postema, H., Baranac, A. Puig, Radi, A., Radogna, R., Raffone, G., Ranieri, A., Rashevski, G., Riccardi, C., Rodozov, M., Rodrigues, A., Ropelewski, L., RoyChowdhury, S., Russo, A., Ryu, G., Ryu, M. S., Safonov, A., Salva, S., Saviano, G., Sharma, A., Sharma, R., Shah, A. H., Shopova, M., Sturdy, J., Sultanov, G., Swain, S. K., Szillasi, Z., Tatarinov, A., Tuuva, T., Tytgat, M., Vai, I., Van Stenis, M., Venditti, R., Verhagen, E., Verwilligen, P., Vitulo, P., Volkov, S., Vorobyev, A., Wang, D., Wang, M., Yang, U., Yang, Y., Yonamine, R., Zaganidis, N., Zenoni, F., and Zhang, A.

Subjects
Physics - Instrumentation and Detectors
Abstract

A novel approach which uses Fibre Bragg Grating (FBG) sensors has been utilised to assess and monitor the flatness of Gaseous Electron Multipliers (GEM) foils. The setup layout and preliminary results are presented., Comment: Two pages, one figure. Presented by Luigi Benussi (corresponding author) to Elba 2015 conference

Published
2015
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