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8 results on '"Bos, Marieke B."'

2. Exploring strategies to reach individuals of Turkish and Moroccan origin for health checks and lifestyle advice : A mixed-methods study

Author

Bukman, Andrea J., Teuscher, Dorit, Meftah, Jamila, Ben, Groenenberg, Iris, Crone, Mathilde R., Dijk, Sandra, Van, Bos, Marieke B., Feskens, Edith J.M., Bukman, Andrea J., Teuscher, Dorit, Meftah, Jamila, Ben, Groenenberg, Iris, Crone, Mathilde R., Dijk, Sandra, Van, Bos, Marieke B., and Feskens, Edith J.M.

Abstract

Background: Low participation rates among ethnic minorities in preventive healthcare services are worrisome and not well understood. The objective of this study was to explore how adults of Turkish and Moroccan origin living in the Netherlands, aged 45 years and older, can be reached to participate in health checks for cardio-metabolic diseases and follow-up (lifestyle) advice. Methods: This mixed-methods study used a convergent parallel design, to combine data of one quantitative study and three qualitative studies. Questionnaire data were included of 310 respondents, and interview data from 22 focus groups and four individual interviews. Participants were recruited via a research database, general practitioners and key figures. Quantitative data were analysed descriptively and qualitative data were analysed using a thematic approach. Results: Regarding health checks, 50 % (95 % CI 41;59) of the Turkish questionnaire respondents and 66 % (95 % CI 57;76) of the Moroccan questionnaire respondents preferred an invitation from their general practitioner. The preferred location to fill out the health check questionnaire was for both ethnic groups the general practitioner's office or at home, on paper. Regarding advice, both groups preferred to receive advice at individual level rather than in a group, via either a physician or a specialised healthcare professional. It was emphasised that the person who gives lifestyle advice should be familiar with the (eating) habits of the targeted individual. Sixty-one percent (95 % CI 53;69) of the Turkish respondents preferred to receive information in their native language compared to 37 % (95 % CI 29;45) of the Moroccan respondents. Several participants mentioned a low proficiency in the local language as an explanation for their preference to fill out the health check questionnaire at home, to receive advice from an ethnic-matched professional, and to receive information in their native language. Conclusions: The general prac

Published
2016

7. The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH

Author

van der Klaauw, Agatha A, primary, Biermasz, Nienke R, additional, Feskens, Edith J M, additional, Bos, Marieke B, additional, Smit, Johannes W A, additional, Roelfsema, Ferdinand, additional, Corssmit, Eleonora P M, additional, Pijl, Hanno, additional, Romijn, Johannes A, additional, and Pereira, Alberto M, additional

Published
2007
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8. Plasma Protein Profiling Reveals Protein Clusters Related to BMI and Insulin Levels in Middle-Aged Overweight Subjects.

Author

Dijk, Susan J. van, Feskens, Edith J. M., Heidema, A. Geert, Bos, Marieke B., Rest, Ondine van de, Geleijnse, Johanna M., de Groot, Lisette C. P. G. M., Müller, Michael, and Afman, Lydia A.

Subjects
BLOOD plasma, PANCREATIC secretions, PROINSULIN, BIOMARKERS, BLOOD proteins, METABOLIC disorders, ENDOCRINE diseases, CHRONIC diseases, LEPTIN
Abstract

Background: Biomarkers that allow detection of the onset of disease are of high interest since early detection would allow intervening with lifestyle and nutritional changes before the disease is manifested and pharmacological therapy is required. Our study aimed to improve the phenotypic characterization of overweight but apparently healthy subjects and to identify new candidate profiles for early biomarkers of obesity-related diseases such as cardiovascular disease and type 2 diabetes. Methodology/Principal Findings: In a population of 56 healthy, middle-aged overweight subjects Body Mass Index (BMI), fasting concentration of 124 plasma proteins and insulin were determined. The plasma proteins are implicated in chronic diseases, inflammation, endothelial function and metabolic signaling. Random Forest was applied to select proteins associated with BMI and plasma insulin. Subsequently, the selected proteins were analyzed by clustering methods to identify protein clusters associated with BMI and plasma insulin. Similar analyses were performed for a second population of 20 healthy, overweight older subjects to verify associations found in population I. In both populations similar clusters of proteins associated with BMI or insulin were identified. Leptin and a number of pro-inflammatory proteins, previously identified as possible biomarkers for obesity-related disease, e.g. Complement 3, C Reactive Protein, Serum Amyloid P, Vascular Endothelial Growth Factor clustered together and were positively associated with BMI and insulin. IL-3 and IL-13 clustered together with Apolipoprotein A1 and were inversely associated with BMI and might be potential new biomarkers. Conclusion/ Significance: We identified clusters of plasma proteins associated with BMI and insulin in healthy populations. These clusters included previously reported biomarkers for obesity-related disease and potential new biomarkers such as IL- 3 and IL-13. These plasma protein clusters could have potential applications for improved phenotypic characterization of volunteers in nutritional intervention studies or as biomarkers in the early detection of obesity-linked disease development and progression. [ABSTRACT FROM AUTHOR]

Published
2010
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