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1. Multidisciplinary treatment of hepatocellular carcinoma in 2023: Italian practice Treatment Guidelines of the Italian Association for the Study of the Liver (AISF), Italian Association of Medical Oncology (AIOM), Italian Association of Hepato-Bilio-Pancreatic Surgery (AICEP), Italian Association of Hospital Gastroenterologists (AIGO), Italian Association of Radiology and Clinical Oncology (AIRO), Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP), Italian Society of Surgery (SIC), Italian Society of Gastroenterology (SIGE), Italian Society of Medical and Interventional Radiology (SIRM), Italian Organ Transplant Society (SITO), and Association of Patients with Hepatitis and Liver Disease (EpaC) – Part II – Non-surgical treatments

Author

Cabibbo, Giuseppe, Daniele, Bruno, Borzio, Mauro, Casadei-Gardini, Andrea, Cillo, Umberto, Colli, Agostino, Conforti, Massimiliano, Dadduzio, Vincenzo, Dionisi, Francesco, Farinati, Fabio, Gardini, Ivan, Giannini, Edoardo Giovanni, Golfieri, Rita, Guido, Maria, Mega, Andrea, Cinquini, Michela, Piscaglia, Fabio, Rimassa, Lorenza, Romanini, Laura, Pecorelli, Anna, Sacco, Rodolfo, Scorsetti, Marta, Viganò, Luca, Vitale, Alessandro, and Trevisani, Franco

Published
2024
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2. Multidisciplinary Treatment of Hepatocellular Carcinoma in 2023: Italian practice Treatment Guidelines of the Italian Association for the Study of the Liver (AISF), Italian Association of Medical Oncology (AIOM), Italian Association of Hepato-Bilio-Pancreatic Surgery (AICEP), Italian Association of Hospital Gastroenterologists (AIGO), Italian Association of Radiology and Clinical Oncology (AIRO), Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP), Italian Society of Surgery (SIC), Italian Society of Gastroenterology (SIGE), Italian Society of Medical and Interventional Radiology (SIRM), Italian Organ Transplant Society (SITO), and Association of Patients with Hepatitis and Liver Disease (EpaC) – Part I – Surgical treatments

Author

Cabibbo, Giuseppe, Daniele, Bruno, Borzio, Mauro, Casadei-Gardini, Andrea, Cillo, Umberto, Colli, Agostino, Conforti, Massimiliano, Dadduzio, Vincenzo, Dionisi, Francesco, Farinati, Fabio, Gardini, Ivan, Giannini, Edoardo Giovanni, Golfieri, Rita, Guido, Maria, Mega, Andrea, Minozzi, Silvia, Piscaglia, Fabio, Rimassa, Lorenza, Romanini, Laura, Pecorelli, Anna, Sacco, Rodolfo, Scorsetti, Marta, Viganò, Luca, Vitale, Alessandro, and Trevisani, Franco

Published
2024
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3. Multidisciplinary Treatment of Hepatocellular Carcinoma in 2023: Italian practice Treatment Guidelines of the Italian Association for the Study of the Liver (AISF), Italian Association of Medical Oncology (AIOM), Italian Association of Hepato-Bilio-Pancreatic Surgery (AICEP), Italian Association of Hospital Gastroenterologists (AIGO), Italian Association of Radiology and Clinical Oncology (AIRO), Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP), Italian Society of Surgery (SIC), Italian Society of Gastroenterology (SIGE), Italian Society of Medical and Interventional Radiology (SIRM), Italian Organ Transplant Society (SITO), and Association of Patients with Hepatitis and Liver Disease (EpaC) – Part I – Surgical treatments

Author

Cabibbo, Giuseppe, primary, Daniele, Bruno, additional, Borzio, Mauro, additional, Casadei-Gardini, Andrea, additional, Cillo, Umberto, additional, Colli, Agostino, additional, Conforti, Massimiliano, additional, Dadduzio, Vincenzo, additional, Dionisi, Francesco, additional, Farinati, Fabio, additional, Gardini, Ivan, additional, Giannini, Edoardo Giovanni, additional, Golfieri, Rita, additional, Guido, Maria, additional, Mega, Andrea, additional, Minozzi, Silvia, additional, Piscaglia, Fabio, additional, Rimassa, Lorenza, additional, Romanini, Laura, additional, Pecorelli, Anna, additional, Sacco, Rodolfo, additional, Scorsetti, Marta, additional, Viganò, Luca, additional, Vitale, Alessandro, additional, and Trevisani, Franco, additional

Published
2023
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6. Contributors

Author

Abdalla, Edson, primary, Alves, Venancio Avancini Ferreira, additional, Balabaud, Charles Paul, additional, Bedossa, Pierre, additional, Bioulac-Sage, Paulette, additional, Borzio, Mauro, additional, Bove, Kevin E., additional, Chalasani, Naga, additional, Di Tommaso, Luca, additional, Duarte, Maria Irma Seixas, additional, Fiel, M. Isabel, additional, Frulio, Nora, additional, Ghabril, Marwan, additional, Gouw, Annette S.H., additional, Griffith, Christopher, additional, Guido, Maria, additional, Guindi, Maha, additional, Hainline, Bryan E., additional, Hübscher, Stefan G., additional, Hytiroglou, Prodromos, additional, Kakar, Sanjay, additional, Kleiner, David E., additional, Kwo, Paul Y., additional, Lackner, Carolin, additional, Mangus, Richard S., additional, Marks, Rebecca A., additional, de Mello, Evandro Sobroza, additional, Morotti, Raffaella A., additional, Neto, Amaro Nunes Duarte, additional, Paradis, Valérie, additional, Park, Young Nyun, additional, Quaglia, Alberto, additional, Roncalli, Massimo, additional, Rush, Natalia, additional, Russo, Pierre, additional, Sandrasegaran, Kumaresan, additional, Sangiovanni, Angelo, additional, Saxena, Romil, additional, Sciarra, Amedeo, additional, Sempoux, Christine, additional, Suriawinata, Arief Antonius, additional, Tector, A. Joseph, additional, Tirkes, Temel, additional, Vuppalanchi, Raj, additional, Washington, Kay, additional, Yeh, Matthew M., additional, Yerian, Lisa M., additional, and Zimmermann, Arthur, additional

Published
2018
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7. Role of Etiology in Hepatocellular Carcinoma Patients Treated with Lenvatinib: A Counterfactual Event-Based Mediation Analysis

Author

Sacco, Rodolfo, primary, Ramai, Daryl, additional, Tortora, Raffaella, additional, di Costanzo, Giovan Giuseppe, additional, Burlone, Michela Emma, additional, Pirisi, Mario, additional, Federico, Piera, additional, Daniele, Bruno, additional, Silletta, Marianna, additional, Gallo, Paolo, additional, Cocuzza, Caterina, additional, Russello, Maurizio, additional, Cabibbo, Giuseppe, additional, Rancatore, Gabriele, additional, Cesario, Silvia, additional, Masi, Gianluca, additional, Marzi, Luca, additional, Mega, Andrea, additional, Granito, Alessandro, additional, Pieri, Giulia, additional, Giannini, Edoardo G., additional, Paolillo, Rosa, additional, Gadaleta-Caldarola, Gennaro, additional, Dadduzio, Vincenzo, additional, Giordano, Guido, additional, Giacomelli, Luca, additional, Papa, Simonetta, additional, Renzulli, Matteo, additional, Maida, Marcello, additional, Ghidini, Michele, additional, Borzio, Mauro, additional, and Facciorusso, Antonio, additional

Published
2023
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8. White Paper of Italian Gastroenterology: Delivery of services for digestive diseases in Italy: Weaknesses and strengths

Author

Actis, Giovanni, Adamo, Salvatore, Amitrano, Lucio, Amuso, Mariano, Ancarani, Ornella, Angelico, Mario, Antonini, Filippo, Badiali, Danilo, Balzano, Antonio, Bardella, Maria Teresa, Barresi, Luca, Bellentani, Stefano, Bellini, Massimo, Benedetti, Antonio, Biagini, Massimiliano, Bianchi, Sabrina, Bianco, Antonietta, Borro, Paolo, Bortoli, Aurora, Bortoluzzi, Francesco, Borzio, Mauro, Boskovski, Ivo, Brosolo, Piero, Brunelli, Eugenio, Brunetto, Maurizia, Buri, Luigi, Burra, Patrizia, Caletti, Giancarlo, Chilovi, Fausto, Cicala, Michele, Ciliberto, Enrico, Cilona, Antonio, Cipolletta, Livio, Claar, Giovanni M., Conigliaro, Rita, Conio, Massimo, Corazziari, Enrico, Costamagna, Guido, Cottone, Mario, Craxì, Antonio, Crotta, Sergio, Cucchiara, Salvatore, Cupella, Francesco, Cuppone, Renato, D’Amico, Gennaro, D’Imperio, Nicola, De Angelis, Claudio, De Pretis, Giovanni, De Stefano, Salvatore, Del Favero, Giuseppe, Del Piano, Mario, Di Cillo, Michele, Di Leo, Alfredo, Di Matteo, Giovanni, Ederle, Andrea, Elli, Luca, Fagiuoli, Stefano, Familiari, Luigi, Familiari, Pietro, Fava, Gianmarco, Federici, Telemaco, Ferrini, Giovanni, Filiberti, Rosa, Fracasso, Pierluigi, Framarin, Luciana, Fregonese, Diego, Frosini, Giorgio, Frulloni, Luca, Fusaroli, Pietro, Gallo, Vincenzo, Gatto, Gianni, Gemme, Carlo, Germanà, Bastianello, Germani, Giacomo, Guardascione, Francesco, Gullotta, Renzo, Hassan, Cesare, Ingrosso, Marcello, Kohn, Anna, Lauri, Adriano, Leandro, Gioacchino, Leo, Piero, Lorenzini, Ivano, Loriga, Piero, Macarri, Giampiero, Magnolfi, Fabrizio, Manta, Raffaele, Marchi, Santino, Marin, Renato, Marini, Mario, Marino, Antonino, Meroni, Emanuele, Milazzo, Giuseppe, Monastra, Santo, Montalbano, Luigi, Morini, Sergio, Muscatiello, Nicola, Natali, Alessandro, Neri, Matteo, Nucci, Andrea, Pace, Fabio, Pallone, Francesco, Parodi, Maria Caterina, Pasquale, Luigi, Penagini, Roberto, Peralta, Sergio, Peruzzi, Egiziano, Piazzi, Lucia, Quondamcarlo, Cinzia, Radaelli, Franco, Rendina, Maria, Ridolfi, Francesco, Rosina, Floriano, Salmi, Andrea, Sansoè, Giovanni, Scafato, Emanuele, Scarpulla, Giuseppe, Solinas, Attilio, Soncini, Marco, Sorrentini, Italo, Spinzi, Giancarlo, Stroppa, Italo, Sturniolo, Giancarlo, Sumberaz, Alessandro, Tammaro, Leonardo, Tarantino, Ilaria, Testino, Gianni, Traina, Mario, Triossi, Omero, Usai-Satta, Paolo, Vilardo, Luigi, Virgilio, Clara, Zambelli, Alessandro, Zilli, Maurizio, Zullo, Angelo, Buscarini, Elisabetta, Conte, Dario, Cannizzaro, Renato, Bazzoli, Franco, De Boni, Michele, Delle Fave, Gianfranco, Farinati, Fabio, Ravelli, Paolo, Testoni, Pier Alberto, Lisiero, Manola, and Spolaore, Paolo

Published
2014
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10. Impact of SARS-CoV-2 Pandemic on the Management of Patients with Hepatocellular Carcinoma

Author

Maria, Guarino, Valentina, Cossiga, Mario, Capasso, Chiara, Mazzarelli, Filippo, Pelizzaro, Rodolfo, Sacco, Francesco Paolo, Russo, Alessandro, Vitale, Franco, Trevisani, Giuseppe, Cabibbo, Baccarani, Umberto, Bhoori, Sherrie, Borzio, Mauro, Brancaccio, Giuseppina, Burra, Patrizia, Casadei Gardini, Andrea, Carrai, Paola, Centonze, Leonardo, Cescon, Matteo, Cillo, Umberto, Cozzolongo, Raffaele, Cucchetti, Alessandro, De Matthaeis, Nicoletta, Di Costanzo, Giovan Giuseppe, Di Sandro, Stefano, Famularo, Simone, Farinati, Fabio, Finotti, Michele, Giuseppe Foschi, Francesco, Galati, Giovanni, Gambato, Martina, Giovanni Giannini, Edoardo, Giuliante, Felice, Ghinolfi, Davide, Gruttaduria, Salvatore, Iavarone, Massimo, Kostandini, Alba, Lai, Quirino, Lenci, Ilaria, Giovanni Lupo, Luigi, Manzia, Tommaso, Marasco, Giovanni, Marenco, Simona, Masarone, Mario, Mazzocato, Susanna, Melandro, Fabio, Mescoli, Claudia, Miele, Luca, Morisco, Filomena, Nicolini, Daniele, Pagano, Duilio, Persico, Marcello, Platz Torres, Maria Corina, Ponziani, Francesca Romana, Pravisani, Riccardo, Rendina, Maria, Renzulli, Matteo, Ricci, Lilia, Romano, Fabrizio, Battista Levi Sandri, Giovanni, Sangiovanni, Angelo, Sposito, Carlo, Tortora, Raffaella, Viganò, Luca, Viganò, Mauro, Vincenzi, Valter, Violi, Pola, Nicoletta, De Matthaeis, Felice, Giuliante (ORCID:0000-0001-9517-8220), Luca, Miele (ORCID:0000-0003-3464-0068), Francesca Romana, Ponziani (ORCID:0000-0002-5924-6238), Maria, Guarino, Valentina, Cossiga, Mario, Capasso, Chiara, Mazzarelli, Filippo, Pelizzaro, Rodolfo, Sacco, Francesco Paolo, Russo, Alessandro, Vitale, Franco, Trevisani, Giuseppe, Cabibbo, Baccarani, Umberto, Bhoori, Sherrie, Borzio, Mauro, Brancaccio, Giuseppina, Burra, Patrizia, Casadei Gardini, Andrea, Carrai, Paola, Centonze, Leonardo, Cescon, Matteo, Cillo, Umberto, Cozzolongo, Raffaele, Cucchetti, Alessandro, De Matthaeis, Nicoletta, Di Costanzo, Giovan Giuseppe, Di Sandro, Stefano, Famularo, Simone, Farinati, Fabio, Finotti, Michele, Giuseppe Foschi, Francesco, Galati, Giovanni, Gambato, Martina, Giovanni Giannini, Edoardo, Giuliante, Felice, Ghinolfi, Davide, Gruttaduria, Salvatore, Iavarone, Massimo, Kostandini, Alba, Lai, Quirino, Lenci, Ilaria, Giovanni Lupo, Luigi, Manzia, Tommaso, Marasco, Giovanni, Marenco, Simona, Masarone, Mario, Mazzocato, Susanna, Melandro, Fabio, Mescoli, Claudia, Miele, Luca, Morisco, Filomena, Nicolini, Daniele, Pagano, Duilio, Persico, Marcello, Platz Torres, Maria Corina, Ponziani, Francesca Romana, Pravisani, Riccardo, Rendina, Maria, Renzulli, Matteo, Ricci, Lilia, Romano, Fabrizio, Battista Levi Sandri, Giovanni, Sangiovanni, Angelo, Sposito, Carlo, Tortora, Raffaella, Viganò, Luca, Viganò, Mauro, Vincenzi, Valter, Violi, Pola, Nicoletta, De Matthaeis, Felice, Giuliante (ORCID:0000-0001-9517-8220), Luca, Miele (ORCID:0000-0003-3464-0068), and Francesca Romana, Ponziani (ORCID:0000-0002-5924-6238)

Abstract

Worldwide, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly increases mortality and morbidity. The Coronavirus Disease 2019 (COVID-19) outbreak has had a considerable impact on healthcare systems all around the world, having a significant effect on planned patient activity and established care pathways, in order to meet the difficult task of the global pandemic. Patients with hepatocellular carcinoma (HCC) are considered a particularly susceptible population and conceivably at increased risk for severe COVID-19 because of two combined risk factors: chronic advanced liver disease and HCC itself. In these challenging times, it is mandatory to reshape clinical practice in a prompt way to preserve the highest standards of patient care and safety. However, due to the stay-at-home measures instituted to stop the spread of COVID-19, HCC surveillance has incurred a dramatic drop, and care for HCC patients has been rearranged by refining the algorithm for HCC treatment to the COVID-19 pandemic, permitting these patients to be safely managed by identifying those most at risk of neoplastic disease progression.

Published
2022

11. The impact of infection by multidrug‐resistant agents in patients with cirrhosis. A multicenter prospective study

Author

Salerno, Francesco, Borzio, Mauro, Pedicino, Claudia, Simonetti, Rosa, Rossini, Angelo, Boccia, Sergio, Cacciola, Irene, Burroughs, Andrew K., Manini, Matteo A., La Mura, Vincenzo, Angeli, Paolo, Bernardi, Mauro, Dalla Gasperina, Daniela, Dionigi, Elena, Dibenedetto, Clara, Arghittu, Milena, Francavilla, Antonio, Trevisani, Franco, Salmi, Andrea, Fatuzzo, Filippo, Arvaniti, Vassiliki, Cambieri, Patrizia, Raguzzi, Ivana, Aghemo, Alessio, Trotta, Elisa, Cottone, Mario, Perricone, Giovanni, Giusti, Massimo, Cazzaniga, Massimo, Gobbo, Giulia, Monti, Valentina, Tejada, Milvana, Costa, Elena, Andriulli, Angelo, and Grossi, Paolo

Published
2017
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13. Acute on Chronic Liver Failure : Role of the Bacterial Infections

Author

Borzio, Mauro and Dionigi, Elena

Subjects
Medical
Abstract

Acute-on-chronic liver failure (ACLF) refers to a syndrome characterized by acute deterioration of liver function of a pre-existing chronic liver disease with increased short-term mortality at 3 months due to multiorgan failure. Definition of ACLF has been refined, but differences between western and eastern areas still exist. Diagnosis of ACLF as recommended by the EASL-CLIF consortium is based on the assessment of organ dysfunction. The pathogenesis of this syndrome is attributable to an exaggerated host response to inflammation, responsible for the severe haemodynamic derangement leading to multiorgan failure. ACLF is triggered by precipitating events like acute hepatitis either viral, drug-induced, toxic, or alcoholic, variceal bleeding and sepsis. Bacterial infection is currently considered the most frequent trigger of ACLF in Western countries. Cirrhotic patients, particularly if decompensated are prone to develop bacterial infection because loss of integrity of the intestinal mucosal barrier and translocation of pathogen-associated molecular patterns (PAMPs). Bacterial translocation may develop into overt infection at different sites, along with sepsis and septic shock that may lead to ACLF. Epidemiology of bacterial infection in cirrhosis has been changing and this accounts for new antibiotic regimens as empirical therapy in critically ill cirrhotic patients with bacterial infection. In this chapter, we will discuss on definition, pathogenesis, clinical aspects and therapy of bacterial infection-related ACLF.

Published
2022

17. Contributors

Author

Abdalla, Edson, primary, Agaram, Narasimhan P., additional, Al-Khawaja, Maha Mahmoud, additional, Alves, Venancio Avancini Ferreira, additional, Balabaud, Charles Paul, additional, Bedossa, Pierre, additional, Bioulac-Sage, Paulette, additional, Borzio, Mauro, additional, Bove, Kevin E., additional, Burlak, Christopher, additional, Chalasani, Naga, additional, Cho, Won Kyoo, additional, Tommaso, Luca Di, additional, Duarte, Maria Irma Seixas, additional, Ghabril, Marwan, additional, Gouw, Annette S.H., additional, Guido, Maria, additional, Guindi, Maha, additional, Hainline, Bryan E., additional, Hart, John, additional, Hübscher, Stefan G., additional, Hytiroglou, Prodromos, additional, Kakar, Sanjay, additional, Kleiner, David E., additional, Knisely, A.S., additional, Kwo, Paul Y., additional, Laumonier, Hervé, additional, Mangus, Richard S., additional, Marks, Rebecca A., additional, de Mello, Evandro Sobroza, additional, Paradis, Valérie, additional, Park, Young Nyun, additional, Quaglia, Alberto, additional, Roncalli, Massimo, additional, Russo, Pierre, additional, Sandrasegaran, Kumaresan, additional, Saxena, Romil, additional, Strahotin, Cristina Simona, additional, Suriawinata, Arief Antonius, additional, Tector, A. Joseph, additional, Theise, Neil D., additional, Thung, Swan N., additional, Venkatesh, Sudhakar, additional, Vuppalanchi, Raj, additional, Wanless, Ian R., additional, Washington, Kay, additional, Yeh, Matthew M., additional, Yerian, Lisa M., additional, and Zimmermann, Arthur, additional

Published
2011
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21. Status of, and strategies for improving, adherence to HCC screening and surveillance

Author

Francica,Giampiero and Borzio,Mauro

Subjects
digestive system diseases, Journal of Hepatocellular Carcinoma
Abstract

Giampiero Francica,1 Mauro Borzio21Unità Operativa Ecografia ed Ecointerventistica, Pineta Grande Hospital, Castel Volturno, Italy; 2Unità Operativa Complessa Gastroenterologia ed Endoscopia Digestiva, Azienda Socio Sanitaria TerritorialeMelegnano e della Martesana, Milano, ItalyAbstract: Hepatocellular carcinoma (HCC) represents the second leading cause of cancer deaths worldwide and the main cause of death in patients with cirrhosis. Secondary prevention of HCC can be accomplished through the serial application of screening tests (ultrasound with or without alpha-fetoprotein) to detect the presence of subclinical lesions amenable to potentially curative treatment, such as surgery and ablation. The efficacy of HCC screening is accepted by hepatologists in terms of decline in cancer-specific mortality, but its translation into clinical practice is less than ideal. The effectiveness of HCC screening is hampered by several factors: failure to identify at-risk patients, failure to access care and failure to detect HCC. For each of these steps, possible improvements are discussed in order to face the changing etiology of cirrhosis and expand the screening of at-risk populations by including selected nonalcoholic fatty liver disease patients.Keywords: cirrhosis, hepatocellular carcinoma, ultrasound, alpha-fetoprotein, screening

Published
2019

25. The impact of infection by multidrug-resistant agents in patients with cirrhosis. A multicenter prospective study

Author

Salerno, Francesco, Borzio, Mauro, Pedicino, Claudia, Simonetti, Rosa, Rossini, Angelo, Boccia, Sergio, Cacciola, Irene, Burroughs, Andrew K., Manini, Matteo A., La Mura, Vincenzo, Angeli, Paolo, Bernardi, Mauro, Dalla Gasperina, Daniela, Dionigi, Elena, Dibenedetto, Clara, Arghittu, Milena, Francavilla, Antonio, Trevisani, Franco, Salmi, Andrea, Fatuzzo, Filippo, Arvaniti, Vassiliki, Cambieri, Patrizia, Raguzzi, Ivana, Aghemo, Alessio, Trotta, Elisa, Cottone, Mario, Perricone, Giovanni, Giusti, Massimo, Cazzaniga, Massimo, Gobbo, Giulia, Monti, Valentina, Tejada, Milvana, Costa, Elena, Andriulli, Angelo, Grossi, Paolo, Salerno, F, Borzio, M, Pedicino, C, Simonetti, R, Rossini, A, Boccia, S, Cacciola, I, Burroughs, Ak, Manini, Ma, La Mura, V, Angeli, P, Bernardi, M, Dalla Gasperina, D, Dionigi, E, Dibenedetto, C, Arghittu, M, and Trevisani, F.

Subjects
Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis, bacterial resistance, cirrhosis, portal hypertension, survival, medicine.drug_class, Antibiotics, survival, 03 medical and health sciences, 0302 clinical medicine, Spontaneous bacterial peritonitis, Antibiotic resistance, Drug Resistance, Multiple, Bacterial, Internal medicine, medicine, Humans, Hospital Mortality, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Aged, Cross Infection, Bacteria, Hepatology, business.industry, cirrhosis, Mortality rate, portal hypertension, Bacterial Infections, bacterial resistance, Middle Aged, Prognosis, medicine.disease, Anti-Bacterial Agents, Surgery, Logistic Models, Italy, Hepatocellular carcinoma, Multivariate Analysis, Female, 030211 gastroenterology & hepatology, business
Abstract

Background & Aims Bacterial strains resistant to antibiotics are a serious clinical challenge. We assessed the antibiotic susceptibility of bacteria isolated from infections in patients with cirrhosis by a multicentre investigation. Results Three hundred and thirteen culture-positive infections (173 community acquired [CA] and 140 hospital acquired [HA]) were identified in 308 patients. Urinary tract infections, spontaneous bacterial peritonitis and bacteremias were the most frequent. Quinolone-resistant Gram-negative isolates were 48%, 44% were extended-spectrum beta-lactamase producers and 9% carbapenem resistant. In 83/313 culture-positive infections (27%), multidrug-resistant agents (MDRA) were isolated. This prevalence did not differ between CA and HA infections. MDRA were identified in 17 of 37 patients on quinolone prophylaxis, and in 46 of 166 not on prophylaxis (45% vs 27%; P

Published
2016

29. Reply

Author

Vitale, Alessandro, primary, Farinati, Fabio, additional, Borzio, Mauro, additional, Trevisani, Franco, additional, and Cllo, Umberto, additional

Published
2019
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31. Iron reduction and sustained response to interferon-α therapy in patients with chronic hepatitis C: results of an Italian multicenter randomized study

Author

Fargion, Silvia, Fracanzani, Anna Ludovica, Rossini, Angelo, Borzio, Mauro, Riggio, Oliviero, Belloni, Giovanni, Bissoli, Franco, Ceriani, Roberto, Ballarè, Marco, Massari, Marco, Trischitta, Caterina, Fiore, Pierluigi, Orlandi, Anna, Morini, Lorenzo, Mattioli, Michela, Oldani, Silvia, Cesana, Bruno, and Fiorelli, Gemino

Published
2002
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32. Restaging Patients With Hepatocellular Carcinoma Before Additional Treatment Decisions: A Multicenter Cohort Study

Author

Vitale, Alessandro, Farinati, Fabio, Noaro, Giulia, Burra, Patrizia, Pawlik, Timothy M., Bucci, Laura, Giannini, Edoardo G., Faggiano, Chiara, Ciccarese, Francesca, Rapaccini, Gian Lodovico, Di Marco, Maria, Caturelli, Eugenio, Zoli, Marco, Borzio, Franco, Sacco, Rodolfo, Cabibbo, Giuseppe, Virdone, Roberto, Marra, Fabio, Felder, Martina, Morisco, Filomena, Benvegnù, Luisa, Gasbarrini, Antonio, Svegliati-Baroni, Gianluca, Foschi, Francesco Giuseppe, Olivani, Andrea, Masotto, Alberto, Nardone, Gerardo, Colecchia, Antonio, Fornari, Fabio, Marignani, Massimo, Vicari, Susanna, Bortolini, Emanuela, Cozzolongo, Raffaele, Grasso, Alessandro Giovanni, Aliberti, Camillo, Bernardi, Mauro, Frigo, Anna Chiara, Borzio, Mauro, Trevisani, Franco, Cillo, Umberto, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Vitale, Alessandro, Farinati, Fabio, Noaro, Giulia, Burra, Patrizia, Pawlik, Timothy M., Bucci, Laura, Giannini, Edoardo G., Faggiano, Chiara, Ciccarese, Francesca, Rapaccini, Gian Lodovico, Di Marco, Maria, Caturelli, Eugenio, Zoli, Marco, Borzio, Franco, Sacco, Rodolfo, Cabibbo, Giuseppe, Virdone, Roberto, Marra, Fabio, Felder, Martina, Morisco, Filomena, Benvegnù, Luisa, Gasbarrini, Antonio, Svegliati-Baroni, Gianluca, Foschi, Francesco Giuseppe, Olivani, Andrea, Masotto, Alberto, Nardone, Gerardo, Colecchia, Antonio, Fornari, Fabio, Marignani, Massimo, Vicari, Susanna, Bortolini, Emanuela, Cozzolongo, Raffaele, Grasso, Alessandro Giovanni, Aliberti, Camillo, Bernardi, Mauro, Frigo, Anna Chiara, Borzio, Mauro, Trevisani, Franco, Cillo, Umberto, and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

Prognostic assessment of patients with hepatocellular carcinoma (HCC) at the time of diagnosis remains controversial and becomes even more complex at the time of restaging when new variables need to be considered. The aim of the current study was to evaluate the prognostic utility of restaging patients before proceeding with additional therapies for HCC. Two independent Italian prospective databases were used to identify 1,196 (training cohort) and 648 (validation cohort) consecutive patients with HCC treated over the same study period (2008-2015) who had complete restaging before decisions about additional therapies. The performance of the Italian Liver Cancer (ITA.LI.CA) prognostic score at restaging was compared with that of the Barcelona Clinic Liver Cancer, Hong Kong Liver Cancer, and Cancer of the Liver Italian Program systems. A multivariable Cox survival analysis was performed to identify baseline, restaging, or dynamic variables that were able to improve the predictive performance of the prognostic systems. At restaging, 35.3% of patients maintained stable disease; most patients were either down-staged by treatment (27.2%) or had disease progression (37.5%). The ITA.LI.CA scoring system at restaging demonstrated the best prognostic performance in both the training and validation cohorts (c-index 0.707 and 0.722, respectively) among all systems examined. On multivariable analysis, several variables improved the prognostic ability of the ITA.LI.CA score at restaging, including progressive disease after the first treatment, Model for End-Stage Liver Disease at restaging, and choice of nonsurgical treatment as additional therapy. A new ITA.LI.CA restaging model was created that demonstrated high discriminative power in both the training and validation cohorts (c-index 0.753 and 0.745, respectively). Conclusion: Although the ITA.LI.CA score demonstrated the best prognostic performance at restaging, other variables should be considered to improve the prognostic a

Published
2018

34. External validation of the ITA.LI.CA prognostic system for patients with hepatocellular carcinoma: A multicenter cohort study

Author

Borzio, Mauro, primary, Dionigi, Elena, additional, Rossini, Angelo, additional, Marignani, Massimo, additional, Sacco, Rodolfo, additional, De Sio, Ilario, additional, Bertolini, Emanuela, additional, Francica, Giampiero, additional, Giacomin, Anna, additional, Parisi, Giancarlo, additional, Vicari, Susanna, additional, Toldi, Anna, additional, Salmi, Andrea, additional, Boccia, Sergio, additional, Mitra, Mario, additional, and Fornari, Fabio, additional

Published
2018
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36. Bacterial Infections Change Natural History of Cirrhosis Irrespective of Liver Disease Severity

Author

Dionigi, Elena, primary, Garcovich, Matteo, additional, Borzio, Mauro, additional, Leandro, Gioacchino, additional, Majumdar, Avik, additional, Tsami, Aikaterini, additional, Arvaniti, Vasiliki, additional, Roccarina, Davide, additional, Pinzani, Massimo, additional, Burroughs, Andrew K, additional, O'Beirne, James, additional, and Tsochatzis, Emmanuel A, additional

Published
2017
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37. Management and prognosis of hepatocellular carcinoma in the elderly: Results of an in-field multicenter cohort study

Author

Borzio, Mauro, primary, Dionigi, Elena, additional, Vitale, Alessandro, additional, Rossini, Angelo, additional, Marignani, Massimo, additional, Fornari, Fabio, additional, Vicari, Susanna, additional, De Sio, Ilario, additional, Farinati, Fabio, additional, Bertolini, Emanuela, additional, Oliveri, Filippo, additional, Leandro, Gioacchino, additional, Francica, Giampiero, additional, Mitra, Mario, additional, Omazzi, Barbara, additional, Boccia, Sergio, additional, Salmi, Andrea, additional, Toldi, Anna, additional, and Sacco, Rodolfo, additional

Published
2017
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39. Trend of Improving Prognosis of Hepatocellular Carcinoma in Clinical Practice: An Italian In-Field Experience

Author

Borzio, Mauro, primary, Dionigi, Elena, additional, Rossini, Angelo, additional, Toldi, Anna, additional, Francica, Giampiero, additional, Fornari, Fabio, additional, Salmi, Andrea, additional, Farinati, Fabio, additional, Vicari, Susanna, additional, Marignani, Massimo, additional, Terracciano, Fulvia, additional, Ginanni, Barbara, additional, and Sacco, Rodolfo, additional

Published
2014
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40. White Paper of Italian Gastroenterology: Delivery of services for digestive diseases in Italy: Weaknesses and strengths

Author

Buscarini, Elisabetta, primary, Conte, Dario, additional, Cannizzaro, Renato, additional, Bazzoli, Franco, additional, De Boni, Michele, additional, Delle Fave, Gianfranco, additional, Farinati, Fabio, additional, Ravelli, Paolo, additional, Testoni, Pier Alberto, additional, Lisiero, Manola, additional, Spolaore, Paolo, additional, Actis, Giovanni, additional, Adamo, Salvatore, additional, Amitrano, Lucio, additional, Amuso, Mariano, additional, Ancarani, Ornella, additional, Angelico, Mario, additional, Antonini, Filippo, additional, Badiali, Danilo, additional, Balzano, Antonio, additional, Bardella, Maria Teresa, additional, Barresi, Luca, additional, Bellentani, Stefano, additional, Bellini, Massimo, additional, Benedetti, Antonio, additional, Biagini, Massimiliano, additional, Bianchi, Sabrina, additional, Bianco, Antonietta, additional, Borro, Paolo, additional, Bortoli, Aurora, additional, Bortoluzzi, Francesco, additional, Borzio, Mauro, additional, Boskovski, Ivo, additional, Brosolo, Piero, additional, Brunelli, Eugenio, additional, Brunetto, Maurizia, additional, Buri, Luigi, additional, Burra, Patrizia, additional, Caletti, Giancarlo, additional, Chilovi, Fausto, additional, Cicala, Michele, additional, Ciliberto, Enrico, additional, Cilona, Antonio, additional, Cipolletta, Livio, additional, Claar, Giovanni M., additional, Conigliaro, Rita, additional, Conio, Massimo, additional, Corazziari, Enrico, additional, Costamagna, Guido, additional, Cottone, Mario, additional, Craxì, Antonio, additional, Crotta, Sergio, additional, Cucchiara, Salvatore, additional, Cupella, Francesco, additional, Cuppone, Renato, additional, D’Amico, Gennaro, additional, D’Imperio, Nicola, additional, De Angelis, Claudio, additional, De Pretis, Giovanni, additional, De Stefano, Salvatore, additional, Del Favero, Giuseppe, additional, Del Piano, Mario, additional, Di Cillo, Michele, additional, Di Leo, Alfredo, additional, Di Matteo, Giovanni, additional, Ederle, Andrea, additional, Elli, Luca, additional, Fagiuoli, Stefano, additional, Familiari, Luigi, additional, Familiari, Pietro, additional, Fava, Gianmarco, additional, Federici, Telemaco, additional, Ferrini, Giovanni, additional, Filiberti, Rosa, additional, Fracasso, Pierluigi, additional, Framarin, Luciana, additional, Fregonese, Diego, additional, Frosini, Giorgio, additional, Frulloni, Luca, additional, Fusaroli, Pietro, additional, Gallo, Vincenzo, additional, Gatto, Gianni, additional, Gemme, Carlo, additional, Germanà, Bastianello, additional, Germani, Giacomo, additional, Guardascione, Francesco, additional, Gullotta, Renzo, additional, Hassan, Cesare, additional, Ingrosso, Marcello, additional, Kohn, Anna, additional, Lauri, Adriano, additional, Leandro, Gioacchino, additional, Leo, Piero, additional, Lorenzini, Ivano, additional, Loriga, Piero, additional, Macarri, Giampiero, additional, Magnolfi, Fabrizio, additional, Manta, Raffaele, additional, Marchi, Santino, additional, Marin, Renato, additional, Marini, Mario, additional, Marino, Antonino, additional, Meroni, Emanuele, additional, Milazzo, Giuseppe, additional, Monastra, Santo, additional, Montalbano, Luigi, additional, Morini, Sergio, additional, Muscatiello, Nicola, additional, Natali, Alessandro, additional, Neri, Matteo, additional, Nucci, Andrea, additional, Pace, Fabio, additional, Pallone, Francesco, additional, Parodi, Maria Caterina, additional, Pasquale, Luigi, additional, Penagini, Roberto, additional, Peralta, Sergio, additional, Peruzzi, Egiziano, additional, Piazzi, Lucia, additional, Quondamcarlo, Cinzia, additional, Radaelli, Franco, additional, Rendina, Maria, additional, Ridolfi, Francesco, additional, Rosina, Floriano, additional, Salmi, Andrea, additional, Sansoè, Giovanni, additional, Scafato, Emanuele, additional, Scarpulla, Giuseppe, additional, Solinas, Attilio, additional, Soncini, Marco, additional, Sorrentini, Italo, additional, Spinzi, Giancarlo, additional, Stroppa, Italo, additional, Sturniolo, Giancarlo, additional, Sumberaz, Alessandro, additional, Tammaro, Leonardo, additional, Tarantino, Ilaria, additional, Testino, Gianni, additional, Traina, Mario, additional, Triossi, Omero, additional, Usai-Satta, Paolo, additional, Vilardo, Luigi, additional, Virgilio, Clara, additional, Zambelli, Alessandro, additional, Zilli, Maurizio, additional, and Zullo, Angelo, additional

Published
2014
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43. Adherence to American Association for the Study of Liver Diseases guidelines for the management of hepatocellular carcinoma: results of an Italian field practice multicenter study

Author

Borzio, Mauro, primary, Fornari, Fabio, additional, De Sio, Ilario, additional, Andriulli, Angelo, additional, Terracciano, Fulvia, additional, Parisi, Giancarlo, additional, Francica, Gianpiero, additional, Salvagnini, Mario, additional, Marignani, Massimo, additional, Salmi, Andrea, additional, Farinati, Fabio, additional, Carella, Alessandra, additional, Pedicino, Claudia, additional, Dionigi, Elena, additional, Fanigliulo, Libera, additional, Cazzaniga, Massimo, additional, Ginanni, Barbara, additional, and Sacco, Rodolfo, additional

Published
2013
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44. Predicting Mortality Risk in Patients With Compensated HCV-Induced Cirrhosis: A Long-Term Prospective Study

Author

Bruno, Savino, primary, Zuin, Massimo, additional, Crosignani, Andrea, additional, Rossi, Sonia, additional, Zadra, Felice, additional, Roffi, Luigi, additional, Borzio, Mauro, additional, Redaelli, Alessandro, additional, Chiesa, Alberto, additional, Silini, Enrico Maria, additional, Almasio, Piero Luigi, additional, and Maisonneuve, Patrick, additional

Published
2009
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45. Reply

Author

Fracanzani, Anna Ludovica, primary, Burdick, Larry, additional, Borzio, Mauro, additional, Roncalli, Massimo, additional, Bonelli, Nicola, additional, Borzio, Franco, additional, Maraschi, Alessandra, additional, Fiorelli, Gemino, additional, and Fargion, Silvia, additional

Published
2002
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46. Iron reduction and sustained response to interferon-alpha therapy in patients with chronic hepatitis C: results of an Italian multicenter randomized study

Author

Fargion, Silvia, primary, Fracanzani, Anna Ludovica, additional, Rossini, Angelo, additional, Borzio, Mauro, additional, Riggio, Oliviero, additional, Belloni, Giovanni, additional, Bissoli, Franco, additional, Ceriani, Roberto, additional, Ballare, Marco, additional, Massari, Marco, additional, Trischitta, Caterina, additional, Fiore, Pierluigi, additional, Orlandi, Anna, additional, Morini, Lorenzo, additional, Mattioli, Michela, additional, Oldani, Silvia, additional, Cesana, Bruno, additional, and Fiorelli, Gemino, additional

Published
2002
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