1. [Use of physiological reparation regulators in glaucoma surgery: a clinicoimmunological study].
- Author
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Kurysheva NI, Marnyhk SA, Borzinok SA, Bochkarev MV, Dolgina EN, and Kizeev MV
- Subjects
- Aged, Aged, 80 and over, Amnion transplantation, Biological Dressings, Cicatrix immunology, Cicatrix metabolism, Female, Fluorouracil therapeutic use, Follow-Up Studies, Humans, Immunosuppressive Agents therapeutic use, Interferon-gamma metabolism, Male, Middle Aged, Postoperative Complications prevention & control, Tears metabolism, Transforming Growth Factor beta metabolism, Transforming Growth Factor beta1, Treatment Outcome, Wound Healing immunology, Cicatrix prevention & control, Glaucoma, Open-Angle surgery, Trabeculectomy methods
- Abstract
The paper presents the comparative results of clinical and immunological studies dealing with the use of the physiological reparation regulators (the human amniotic membrane and systemic enzyme therapy) and the antimetabolite 5-fluorouracil (5-FU) to prevent excessive ocular tissue scarring. The clinical observations have demonstrated the high efficiency of the proposed methods for the physiological regulation of reparative processes as compared with the use of 5-FU, which manifested as a more marked normalization ofophthalmotonus and fewer numbers of postoperative complications. The investigation of the study of proliferation-activating cytokine (TGF-beta1) and antiprolerative cytokine (IFN-gamma) has demonstrated the immunomodulating properties of the physiological reparation regulators used in the present study.
- Published
- 2005